Patent application number | Description | Published |
20080296194 | NESTABLE AND STACKABLE CONTAINER FOR THE TRANSPORT OF HEAVY BAKED ITEMS - A container for containing and transporting baked goods is described herein. The container includes a front wall, left side wall, rear wall and a right side wall, wherein each of the walls is substantially orthogonal to a base. The base includes a substantially flat, smooth upper surface, whereby baked goods that are being stored and/or transported are prevented from being damaged. Integrally formed as part of and rising from the base are a plurality of base projections, each with a plurality of sloped curved wall surfaces that substantially prevent packages of the baked goods from shifting and/or sliding when in transit, thereby further preventing damage. The radii of curvature of the curved surfaces of the base projections is substantially similar to the radii of curvature of the packages of baked goods, as well as the baked goods themselves. There are at least two stacking feet per wall of the container, thereby providing operators with the ability to transport and store different types of baked goods, for example baked tortillas, which are generally heavier than most baked goods. The container described herein further includes 180° stacking recesses located on a rim that surrounds the container and that substantially prevent an upper container from shifting or sliding when stacked in a 180° stacking orientation, preferably for the transportation of baked goods. Each of the recesses further comprises a “U” or “[” shaped projection to interface and retain the stacking feet of an upper container when stacked in the 180° stacking orientation. | 12-04-2008 |
20090314675 | BEVERAGE CRATE WITH CONSTANT-DIAMETER POCKETS - A nestable crate or container for holding bottles. The crate has a floor portion substantially in a first plane having a plurality of bottle seating areas, with each bottle seating area being adapted to receive a lower portion of a bottle. The crate also includes a peripheral wall surrounding the floor portion and extending upward from the floor portion, a plurality of central columns extending upward from the floor portion and oriented proximate to a longitudinal centerline of the crate, and a plurality of pylons extending upward from the floor portion along the periphery of the crate. Each central column includes at least one first bottle-contacting surface and each pylon includes at least one second bottle-contacting surface. Both the first and second bottle contacting surfaces are substantially orthogonal to the first plane. | 12-24-2009 |
20100196134 | STACKABLE PACKAGED GOODS PALLET - A pallet for shipping and displaying of packaged goods wherein the pallet comprises a plurality of stacking feet joined together by angled ribs to substantially prevent or inhibit spreading of the stacking feet due to high weight loads, a plurality of handles that include handle-strengthening areas and finger recesses to increase the strength and lifting ergonomics of the pallet, and an angled surface on the bottom of the stacking feet to facilitate transporting of the loaded pallet from a distribution vehicle to a retail location over certain obstacles. Accordingly, the packaged goods can comprise beverage trays filled or partially filled with beverage bottles, or any good and/or raw material for sale and/or use in manufacturing. | 08-05-2010 |
20100230318 | Multiple Cap Size Bottle Crate - A beverage crate having a bottom wall, a first side wall, a second side wall, a first end wall and a second end wall. The bottom wall includes a lower surface having structure to allow the beverage crate to securely stack on a plurality of bottles having a first cap size or a plurality of bottles having a second cap size. The lower surface of the bottom wall including a plurality of bottle receiving portions where each bottle receiving portion includes a first cap size wall portion and a second cap size wall portion. | 09-16-2010 |
20100288654 | Bottle Crate - A bottle crate ( | 11-18-2010 |
20100300912 | Beverage Crate with Constant-Diameter Pockets - A nestable crate or container for holding bottles. The crate has a floor portion substantially in a first plane having a plurality of bottle seating areas, with each bottle seating area being adapted to receive a lower portion of a bottle. The crate also includes a peripheral wall surrounding the floor portion and extending upward from the floor portion, a plurality of central columns extending upward from the floor portion and oriented proximate to a longitudinal centerline of the crate, and a plurality of pylons extending upward from the floor portion along the periphery of the crate. Each central column includes at least one first bottle-contacting surface and each pylori includes at least one second bottle-contacting surface. Both the first and second bottle contacting surfaces are substantially orthogonal to the first plane. | 12-02-2010 |
20120073248 | Breadbasket with Merchandiser Window and Flaps - A basket for shipping and displaying of baked products, wherein the basket comprises several features that substantially inhibit or reduce lateral motion, as well frontward and rearwards motion. Similar baskets can be stacked in a 0°, 90° or 180° configuration, and in the 0° and 180°, an upper basket can pivot and slide about a lower basket. Preferably, three window flaps are provided in one or more merchandising windows of the basket to allow consumers to retrieve baked product from an interior portion of the basket. The window flaps can moved from an open position to provide customers access to the tray, to a closed position to substantially inhibit or prevent product spillage when being transported or stored. | 03-29-2012 |
20120241350 | Three Tiered Tray - A highly efficient bakery tray is provided. The tray includes a square base and is configured to stack upon another like tray in any of three or four orientations to provide three or four different product clearance heights between the trays. | 09-27-2012 |
20130126375 | Bottle Crate - A bottle crate ( | 05-23-2013 |
20140110295 | Bottle Crate - A bottle crate ( | 04-24-2014 |
20140124403 | Front-To-Front Low Position Tray - A tray having a first clearance height when stacked in a front-to-front orientation with a like tray and a second clearance height when stacked in a back-to-front orientation with the like tray is provided. The first clearance height is lower than the second clearance height. | 05-08-2014 |
20140291185 | Beverage Crate with Constant-Diameter Pockets - A nestable crate or container for holding bottles. The crate has a floor portion substantially in a first plane having a plurality of bottle seating areas, with each bottle seating area being adapted to receive a lower portion of a bottle. The crate also includes a peripheral wall surrounding the floor portion and extending upward from the floor portion, a plurality of central columns extending upward from the floor portion and oriented proximate to a longitudinal centerline of the crate, and a plurality of pylons extending upward from the floor portion along the periphery of the crate. Each central column includes at least one first bottle-contacting surface and each pylon includes at least one second bottle-contacting surface. Both the first and second bottle contacting surfaces are substantially orthogonal to the first plane. | 10-02-2014 |
Patent application number | Description | Published |
20090276787 | PERFORMING DYNAMIC SIMULATIONS WITHIN VIRTUALIZED ENVIRONMENT - A method and apparatus for and article of manufacture for simulating workloads experienced by multiple partitions in a virtualized system are provided. A master workload driver initiates, coordinates and regulates one or more workload drivers that execute one or more workload simulation tasks in a logical partition. Further, each workload driver may be configured to report a measure of performance regarding the workload to the master control driver where results of many workload drivers may be correlated and analyzed. A configuration file specifies the characteristics of each simulation. Further, the rate and nature of workloads may be adjusted dynamically during a given simulation to model the performance under different real-world scenarios of different computational loads that may be experienced by the virtualized system. | 11-05-2009 |
20090281847 | Method and System For Data Disaggregation - A method and system for migrating source data from a source database to a destination database based on energy efficiency and conservation. A migration server evaluates the source data for usage and requirements and defines data usage and requirement tags for the source data. The source data is disaggregated into one or more source data sets based on the data usage and requirement tags. The migration server then identifies candidate destinations for the source data, wherein each candidate destination has stored data identified with usage and requirement tags. The data migration server compares the first usage and requirement tags of the source data with the second usage and requirement tags of the stored data and identifies an optimal destination database based on the comparing step. The data migration server migrates the source data to the optimal destination database. | 11-12-2009 |
20090282044 | Energy Efficient Data Provisioning - A method and system for provisioning data that has been collected and stored in a source database. The source database is a database that consumes a large amount of power and drains the company's database resources. The method and system determine which data should be provisioned and sent to a target server, the target server being more energy efficient than the source database and less exhausting of company resources. Various factors, such as the amount of data being requested and the frequency of change of the requested data, determine whether a transfer of data from the source database to the more energy efficient target database should be performed. | 11-12-2009 |
20090282090 | Method and System For Data Dispatch - A method and system for migrating source data from one or more databases to a destination database, wherein the destination database is selected based on power consumption of the destination database. A data migration server determines which destination database should be selected by selecting a number of candidates and comparing the power consumed, the available space and the maximum monthly power consumption limit. A user intervention policy is created to evaluate which data should be moved to a destination database. A “payback period” is calculated to determine the amount of time that will elapse before savings are realized. | 11-12-2009 |
20090282273 | Method and System For Data Migration - A method and system for migrating source data from one or more databases to a destination database, wherein the destination database is selected based on power consumption of the destination database. A data migration server determines which destination database should be selected by selecting a number of candidates and comparing the power consumed, the available space and the maximum monthly power consumption limit. A user intervention policy is created to evaluate which data should be moved to a destination database. A “payback period” is calculated to determine the amount of time that will elapse before savings are realized. | 11-12-2009 |
20150295793 | HIGH-PERFORMANCE COMPUTING EVALUATION - In one embodiment, a computer-implemented method includes iteratively running a client application on two or more combinations of two or more hardware platforms and one or more software products, where the two or more hardware platforms and the one or more software products reside in an integrated evaluation appliance. The running of the client application on the two or more combinations is monitored by a computer processor. A result of running the client application on a first hardware platform and a result of running the client application on a second hardware platform are output, where the first hardware platform and the second hardware platform are among the two or more hardware platforms residing in the evaluation appliance. | 10-15-2015 |
20150295794 | HIGH-PERFORMANCE COMPUTING EVALUATION - In one embodiment, a computer-implemented method includes iteratively running a client application on two or more combinations of two or more hardware platforms and one or more software products, where the two or more hardware platforms and the one or more software products reside in an integrated evaluation appliance. The running of the client application on the two or more combinations is monitored by a computer processor. A result of running the client application on a first hardware platform and a result of running the client application on a second hardware platform are output, where the first hardware platform and the second hardware platform are among the two or more hardware platforms residing in the evaluation appliance. | 10-15-2015 |
Patent application number | Description | Published |
20090242599 | ROOF RACK ASSEMBLY WITH STOWABLE CROSS MEMBERS - A roof rack assembly for a vehicle is provided with a first and a second elongated roof rail substantially parallel and spaced from one another. An elongated cross member is secured to the first roof rail and configured to be selectively securable to the second roof rail. The cross member is pivotable between a stowed position and a use position, also referred to as a deployed position. The cross member is substantially parallel with the first roof rail and is not secured to the second roof rail in the stowed position, and not parallel with the first roof rail and secured to the second roof rail in the use position. In the stowed position, the cross member may be within a cavity defined by the roof rail. Two cross members may be used, each being stowable in a different one of the roof rails. | 10-01-2009 |
20100301580 | VEHICLE WITH STEP ASSEMBLY - A vehicle includes a vehicle body. The body defines a wheel well and has a body panel that at least partially defines an opening of the wheel well. A wheel is operatively connected to the vehicle body, is selectively rotatable about an axis, and is at least partially disposed within the wheel well. A member has a first end and a second end. The first end is rotatably mounted with respect to the body panel forward of the axis. The second end is rotatably mounted with respect to the body panel rearward of the axis. | 12-02-2010 |
20110293385 | VEHICLE ADAPTED TO CARRY ELONGATE CARGO - A vehicle adapted to carry elongate cargo includes, but is not limited to, a body having a cargo support surface having a first opening. A first support member is housed within the first opening and is configured to move inwardly and outwardly with respect to the first opening. A first restraining member is connected to the first support member and oriented generally transversely thereto. The first restraining member is configured to move towards and away from the cargo support surface as the first support member moves inwardly and outwardly with respect to the first opening, and to compress the elongate cargo against the cargo support surface. The body is configured to engage the first support member and to inhibit the first support member from moving away from the body. The first restraining member and the cargo support surface cooperate to restrain the elongate cargo. | 12-01-2011 |
Patent application number | Description | Published |
20110022947 | SYSTEM AND METHOD FOR DYNAMIC REGENERATION OF PAGE FRAGMENTS - Disclosed herein are embodiments of a system and method for the provisioning of dynamically generated content. One embodiment can interface a content delivery system and a content management system at the fragment level. Depending upon how a page is organized, a fragment may refer to a block within the page, a portion of the page, or a content item presented on the page. When a content item is updated and published onto the content management system, one embodiment of the invention can operate to track dependencies of managed pages and invalidate/validate fragment(s) affected by the change(s) accordingly. The updated fragment(s) may then be dynamically assembled on-the-fly or on-demand. The updated fragment(s) may or may not be cached. In this way, changes made to a piece of content can be reflected in all pages which utilize this content almost simultaneously with the changes to the content itself. | 01-27-2011 |
20120303765 | SYSTEM USING CONTENT GENERATOR FOR DYNAMICALLY REGENERATING ONE OR MORE FRAGMENTS OF WEB PAGE BASED ON NOTIFICATION OF CONTENT CHANGE - Disclosed herein are embodiments of a system and method for the provisioning of dynamically generated content. One embodiment can interface a content delivery system and a content management system at the fragment level. Depending upon how a page is organized, a fragment may refer to a block within the page, a portion of the page, or a content item presented on the page. When a content item is updated and published onto the content management system, one embodiment of the invention can operate to track dependencies of managed pages and invalidate/validate fragment(s) affected by the change(s) accordingly. The updated fragment(s) may then be dynamically assembled on-the-fly or on-demand. The updated fragment(s) may or may not be cached. In this way, changes made to a piece of content can be reflected in all pages which utilize this content almost simultaneously with the changes to the content itself. | 11-29-2012 |
20130232227 | SYSTEM AND METHOD FOR FRAGMENT LEVEL DYNAMIC CONTENT REGENERATION - A system and method for provisioning dynamically generated content. One embodiment can interface a content delivery system and a content management system at the fragment level. Depending upon how a page is organized, a fragment may refer to a block within the page, a portion of the page, or a content item presented on the page. When a content item is updated and published onto the content management system, one embodiment can operate to track dependencies of managed pages and invalidate/validate fragment(s) affected by the change(s) accordingly. The updated fragment(s) may then be dynamically assembled on-the-fly or on-demand. The updated fragment(s) may or may not be cached. In this way, changes made to a piece of content can be reflected in all pages which utilize this content almost simultaneously with the changes to the content itself. | 09-05-2013 |
20140201615 | System and method for the dynamic provisioning of static content - Disclosed herein are embodiments of a system and method for the dynamic provisioning of static content. In one embodiment, information presented on a content delivery system can be refreshed based on information published on a content management system. One embodiment can interface the content delivery system and the content management system at the page level. More specifically, content dependencies across pages employing the same content or portion(s) thereof can be tracked in a timely, accurate manner. Upon receiving a notification of a change to the content or a portion thereof from the content management system, a content generation system may operate to determine, based on the dependencies, what pages are affected by the change and, based on the determination, dynamically regenerate any and all affected pages. The regenerated pages may then be stored and/or pushed to the web tier for delivery to end users. | 07-17-2014 |
20150095762 | SYSTEM AND METHOD FOR THE DYNAMIC PROVISIONING OF STATIC CONTENT - Disclosed herein are embodiments of a system and method for the dynamic provisioning of static content. In one embodiment, information presented on a content delivery system can be refreshed based on information published on a content management system. One embodiment can interface the content delivery system and the content management system at the page level. More specifically, content dependencies across pages employing the same content or portion(s) thereof can be tracked in a timely, accurate manner. Upon receiving a notification of a change to the content or a portion thereof from the content management system, a content generation system may operate to determine, based on the dependencies, what pages are affected by the change and, based on the determination, dynamically regenerate any and all affected pages. The regenerated pages may then be stored and/or pushed to the web tier for delivery to end users. | 04-02-2015 |
Patent application number | Description | Published |
20080281858 | ITINERARY SEARCH TOOL FOR TERRITORY MANAGEMENT - Electronically creating an itinerary schedule in a calendar program. A geographic indicator and a calendar date are acquired and coordinated with each other to define an itinerary entry. The itinerary entry is included into a calendar program maintained by the machine. The step of acquiring the geographic indicator further comprises the step of updating a counter upon each selection of a geographic indicator. Another method electronically populates a calendar program with an event using an itinerary entry. Optionally, health care providers from within a geographic indicator are included in the itinerary entry. A geographic indicator and calendar date are obtained from an itinerary entry, and additional search criteria are input. A search of a database is executed to identify candidates matching the geographic indicator and search criteria. Candidate matches are assigned to a time slot, and each time slot is populated into the calendar program on the calendar date. | 11-13-2008 |
20120004941 | CYCLE PLANNING TOOL WITH EVENT CONFLICT RESOLUTION FOR TERRITORY MANAGEMENT - Electronically creating a schedule plan of events which replicates one or more previously scheduled events. A source date range is acquired into a memory of a machine A set of previously scheduled events within the source date range is identified. A target date range is received through a user interface. At least a portion of the previously scheduled events is assigned to a date within the received target date range to create the schedule plan. The schedule plan is posted to a calendar. Another method creates a schedule plan on the basis of one or more search criteria used for identifying any match from a database. At least a portion of any matches are assigned a time slot within a target date range of a calendar program. | 01-05-2012 |
20140149134 | Pharmaceutical Representative Expense Report Management Software, Systems, And Methodologies - Electronic assigning of expense data related to sales calls to customers such as health care professionals (HCPs) aids in complying with local, state, federal, or other regulatory reporting requirements and guidelines. The method includes providing expense report data and presenting a line-item entry of the report on a display. Through a user interface, one or more customers included within a database are selected. An expense amount associated with the line-item entry is automatically allocated into dollar amounts among the selected customer(s) and entries in the database are updated for each selected customer to now include the allocated dollar amounts. | 05-29-2014 |
20140250224 | ADVERSE EVENT DATA CAPTURE AND ALERT SYSTEMS AND METHODS - Electronic capture of adverse event information includes selective input of adverse event information into a machine in response to prompt provided to the user based on a site visit. Such adverse event information is forwardable to a location over a communication link. The machine produces one or more alerts, if adverse event information has been input, after a prescribed period of time has transpired unless the machine is informed that the same information has already been forwarded to the location. In a preferred embodiment, the customer is a clinician. Optionally, received adverse event information can be parsed to audit whether any of the information, in fact, concerns an adverse event. Systems and software concerning related technological improvements are disclosed. | 09-04-2014 |
Patent application number | Description | Published |
20120035957 | ELECTRONIC PRESCRIPTION DELIVERY SYSTEM AND METHOD - The invention is a computer-implemented method and apparatus that delivers information to a prescriber that is prescribing medication via an electronic prescription system, the information is delivered at the time of entering the prescription and prior to completion of entering the prescription information. The information delivered is responsive to information about the prescriber, the patient, and/or other relevant conditions from any or all of a number of sources. The information delivered to the prescriber may include drug interaction information, warnings, legally required statements, potential alternative medications, advertisements, coupons, etc. The data to which the specific information delivered to the prescriber is responsive may include prescriber information, such as the location, age, gender, medical specialty, practice size, geographic location etc, information about the patient, such as age, gender, insurance information, location, previous medical history, height, weight, etc. The data also may include information not specific to the prescriber or patient per se, such as local or national laws, current local weather, local allergen counts, etc. The data may be collected from various sources, including the prescriber's medical records database, insurance carrier databases, public information available over the internet or from other sources, purchased information such as subscription lists, weather, pollution, and allergy information, etc. | 02-09-2012 |
Patent application number | Description | Published |
20120035957 | ELECTRONIC PRESCRIPTION DELIVERY SYSTEM AND METHOD - The invention is a computer-implemented method and apparatus that delivers information to a prescriber that is prescribing medication via an electronic prescription system, the information is delivered at the time of entering the prescription and prior to completion of entering the prescription information. The information delivered is responsive to information about the prescriber, the patient, and/or other relevant conditions from any or all of a number of sources. The information delivered to the prescriber may include drug interaction information, warnings, legally required statements, potential alternative medications, advertisements, coupons, etc. The data to which the specific information delivered to the prescriber is responsive may include prescriber information, such as the location, age, gender, medical specialty, practice size, geographic location etc, information about the patient, such as age, gender, insurance information, location, previous medical history, height, weight, etc. The data also may include information not specific to the prescriber or patient per se, such as local or national laws, current local weather, local allergen counts, etc. The data may be collected from various sources, including the prescriber's medical records database, insurance carrier databases, public information available over the internet or from other sources, purchased information such as subscription lists, weather, pollution, and allergy information, etc. | 02-09-2012 |
Patent application number | Description | Published |
20090010879 | Receptor Based Antagonists and Methods of Making and Using - The present invention provides a fusion polypeptide capable of binding a cytokine to form a nonfunctional complex. It also provides a nucleic acid sequence encoding the fusion polypeptide and methods of making and uses for the fusion polypeptide. | 01-08-2009 |
20090137416 | Isolating Cells Expressing Secreted Proteins - A method of detecting and isolating cells that produce a secreted protein of interest (POI) that has a T cell receptor variable domain, comprising: a) constructing a cell line transiently or stably expressing a cell surface capture molecule, which binds the POI, by transfecting the cell line with a nucleic acid that encodes such cell surface capture molecule; b) transfecting said cell simultaneously or subsequently with a second nucleic acid that encodes a POI wherein such POI is secreted; c) detecting the surface-displayed POI by contacting the cells with a detection molecule, which binds the POI; and d) isolating cells based on the detection molecule. | 05-28-2009 |
20140017695 | ISOLATING CELLS EXPRESSING SECRETED PROTEINS - A method of detecting and isolating cells that produce a secreted protein of interest (POI) that has a T cell receptor variable domain, comprising: a) constructing a cell line transiently or stably expressing a cell surface capture molecule, which binds the POI, by transfecting the cell line with a nucleic acid that encodes such cell surface capture molecule; b) transfecting said cell simultaneously or subsequently with a second nucleic acid that encodes a POI wherein such POI is secreted; c) detecting the surface-displayed POI by contacting the cells with a detection molecule, which binds the POI; and d) isolating cells based on the detection molecule. | 01-16-2014 |
20140044730 | ANTI-PCSK9 ANTIBODIES WITH pH-DEPENDENT BINDING CHARACTERISTICS - The present invention provides antibodies and antigen-binding fragments thereof that specifically bind proprotein convertase subtilisin/kexin-9 (PCSK9) with greater affinity at neutral pH than at acidic pH. The antibodies of the invention may possess one or more amino acid changes as compared to antibodies that do not exhibit pH-dependent binding properties. For example, the present invention includes anti-PCSK9 antibodies which possess one or more histidine substitutions in one or more complementarity determining regions. The antibodies of the invention, with pH-dependent binding properties, remain in circulation and exhibit cholesterol lowering activity for prolonged periods of time in animal subjects as compared to anti-PCSK9 antibodies that do not exhibit pH-dependent binding properties. The antibodies of the invention are therefore useful for treating diseases and disorders related to elevated HDL cholesterol, wherein the antibodies of the invention can be administered to a patient at a lower dose and/or with less frequent dosing as compared to antibodies that do not exhibit pH-dependent binding properties. | 02-13-2014 |
20140072979 | ISOLATING CELLS EXPRESSING SECRETED PROTEINS - A method of detecting and isolating cells that produce a secreted protein of interest (POI) that has an immunoglobulin CH3 domain and/or substituted CH3 domain, comprising: a) constructing a cell line transiently or stably expressing a cell surface capture molecule, which binds the POI, by transfecting the cell line with a nucleic acid that encodes such cell surface capture molecule; b) transfecting said cell simultaneously or subsequently with a second nucleic acid that encodes a POI wherein such POI is secreted; c) detecting the surface-displayed POI by contacting the cells with a detection molecule, which binds the POI; and d) isolating cells based on the detection molecule. | 03-13-2014 |
20140072980 | ISOLATING CELLS EXPRESSING SECRETED PROTEINS - A method of detecting and isolating cells that produce a secreted protein of interest (POI) that has an immunoglobulin CH3 domain and/or substituted CH3 domain, comprising: a) constructing a cell line transiently or stably expressing a cell surface capture molecule, which binds the POI, by transfecting the cell line with a nucleic acid that encodes such cell surface capture molecule; b) transfecting said cell simultaneously or subsequently with a second nucleic acid that encodes a POI wherein such POI is secreted; c) detecting the surface-displayed POI by contacting the cells with a detection molecule, which binds the POI; and d) isolating cells based on the detection molecule. | 03-13-2014 |
20140356372 | Methods for treating allergy and enhancing allergen-specific immunotherapy by administering an IL-4R inhibitor - The present invention provides methods for treating, preventing or reducing the severity of allergic reactions. The present invention also provides methods for enhancing the efficacy and/or safety of an allergen-specific immunotherapy (SIT) regimen. The methods of the present invention comprise administering to a subject in need thereof a therapeutic composition comprising an interleukin-4 receptor (IL-4Rα) antagonist such as an anti-IL-4Rα antibody. | 12-04-2014 |
20150160215 | ISOLATING CELLS EXPRESSING SECRETED PROTEINS - A method of detecting and isolating cells that produce a secreted protein of interest (POI), for example, an antibody, comprising: a) constructing a cell line transiently or stably expressing a cell surface capture molecule, which binds the POI, by transfecting the cell line with a nucleic acid that encodes such cell surface capture molecule; b) transfecting said cell simultaneously or subsequently with a second nucleic acid that encodes a POI wherein such POI is secreted; c) detecting the surface-displayed POI by contacting the cells with a detection molecule, which binds the POI; and d) isolating cells based on the detection molecule. | 06-11-2015 |
20150203591 | MUTIVALENT ANTIGEN-BINDING PROTEINS - Multivalent antigen-binding proteins comprising two or three or four or more immunoglobulin heavy chain variable domain binding domains are provided, as are methods for making them, nucleic acid constructs, and cell lines for making them. Proteins comprising two or three or four or more different heavy chain variable domains that lack an immunoglobulin variable domain are provided. Proteins comprising two or three or four or more different heavy chain variable domains that associate with the same immunoglobulin light chain variable domain are also provided. | 07-23-2015 |
20150337029 | Human Antibodies to Middle East Respiratory Syndrome - Coronavirus Spike Protein - The present invention provides monoclonal antibodies that bind to the Middle East Respiratory Syndrome-Coronavirus (MERS-CoV) spike protein, and methods of use. In various embodiments of the invention, the antibodies are fully human antibodies that bind to MERS-CoV spike protein. In some embodiments, the antibodies of the invention are useful for inhibiting or neutralizing MERS-CoV activity, thus providing a means of treating or preventing MERS infection in humans. In some embodiments, the invention provides for a combination of one or more antibodies that bind to the MERS-CoV spike protein for use in treating MERS infection. In certain embodiments, the one or more antibodies bind to distinct non-competing epitopes comprised in the receptor binding domain of the MERS-CoV spike protein. | 11-26-2015 |
20160024208 | HUMAN ANTIBODIES TO NAV1.7 - The present invention provides antibodies that bind to the human voltage gated sodium channel designated Na | 01-28-2016 |
20160033530 | ISOLATING CELLS EXPRESSING SECRETED PROTEINS - A method of detecting and isolating cells that produce a secreted protein of interest (POI), for example, an antibody, comprising: a) providing a eukaryotic cell comprising (i) a nucleic acid encoding the POI, and (ii) a nucleic acid encoding a cell surface capture molecule, which comprises a membrane anchor and is capable of binding the POI; (b) culturing the cell under conditions in which the POI and cell surface capture molecule are expressed, and a POI-cell surface capture molecule complex is formed intracellularly and displayed on the cell surface; c) detecting the surface-displayed POI by contacting the cells with a detection molecule, which binds the POI; and d) isolating cells based on the detection molecule. | 02-04-2016 |
Patent application number | Description | Published |
20120313759 | Tracking system for persons and/or objects - An RFID-based tracking system that tracks persons and/or objects of interest without the need for triangulation techniques is disclosed. The system tracks persons and/or objects of interest by utilizing RFID antennas having a relatively small field of view and positioned relative to functional areas of a facility and/or within passageways between functional areas of the facility. The persons and/or objects of interest to be tracked are provided with an RFID tag. The present invention provides the system user with the ability to determine whether the persons and/or objects of interest are present within a particular functional area of the facility regardless of whether the presence of the person and/or object of interest is continuously detected by the system. | 12-13-2012 |
20140210617 | System to facilitate well-being checks - A system for checking the well-being of individuals within an institution is disclosed. The system is comprised of portable wireless devices in the possession of individual(s) who are to perform the well-being checks, a wireless communication network, and a computer device that is connected to the portable wireless devices by the wireless communication network. The computer device executes well-being software and is provided with well-being databases containing the well-being checks to be performed for each person, and has access to a tracking system. The tracking system determines the location of the person on whom such well-being checks are to be performed, the individual performing such well-being checks, and monitors and records whether such well-being checks have been performed. | 07-31-2014 |
20150015407 | Display system for tracking large numbers of persons and/or objects - A display system for tracking large numbers of persons or objects in real-time is disclosed. The display system utilizes a tracking system that employs various types of technologies, such as RFID, to determine the location of the person and/or objects being tracked. The displays of the present invention utilize colors, graphics, and the physical groupings of related data on a display device, usually a computer monitor, to present tracking information in a compact, readily changeable, and easily analyzed format in real-time. | 01-15-2015 |
Patent application number | Description | Published |
20090079146 | AXLE AIR DUMP FOR MULTIPLE AXLE VEHICLES - A system and process for controlling vehicle loading on a multi-axle vehicle and improving maneuverability is disclosed. The system includes a reservoir of pressurized air and associated leveling valve that uses a relay valve to improve refill times when the vehicle returns from a dump mode operation to normal operation. The process reduces pressure in one or more of the axles when maneuvering the vehicle at predetermined slow speeds and maintaining that first predetermined pressure while the other axle(s) is at a greater pressure than the first axle. By preventing complete exhaustion of pressure from the suspension system, restoring air pressure is attained more quickly. Also, use of a relay valve enables higher flow rates to improve the refill time of the pneumatic suspension system after the dump operation. | 03-26-2009 |
20100201085 | AXLE AIR DUMP FOR MULTIPLE AXLE VEHICLES - A system and process for controlling vehicle loading on a multi-axle vehicle and improving maneuverability is disclosed. The system includes a reservoir of pressurized air and associated leveling valve that uses a relay valve to improve refill times when the vehicle returns from a dump mode operation to normal operation. The process reduces pressure in one or more of the axles when maneuvering the vehicle at predetermined slow speeds and maintaining that first predetermined pressure while the other axle(s) is at a greater pressure than the first axle. By preventing complete exhaustion of pressure from the suspension system, restoring air pressure is attained more quickly. Also, use of a relay valve enables higher flow rates to improve the refill time of the pneumatic suspension system after the dump operation. | 08-12-2010 |
20120296543 | AUTOMATIC WORK BRAKE - A vehicle, air brake system is presented with an improved service work brake arrangement. The arrangement may provide a service work brake function or both a service work brake function and a parking brake function for the vehicle. The arrangement may provide an improved service work brake arrangement disposed within a housing for reducing the number of components and plumbing required to achieve this functionality versus prior known systems. The arrangement may utilizes a pneumatic latching valve to deliver pressurized air for applying a vehicle's service brakes. The pneumatic latching valve opens upon receiving a pneumatic control signal from an electronically controlled valve and closes upon receiving a pneumatic control signal from another source. In addition, a controller and control logic may be provided for controlling the arrangement. | 11-22-2012 |
20130090820 | ELECTRONIC CONTROL UNIT CONFIGURATION TOOL - A tool for configuring a replacement electronic control unit for a vehicle is provided. The tool includes a computer storage medium having a computer program encoded thereon which may be stored on an electronic module or installed on a computing device that connects to a communications bus in the vehicle. The program includes code for accessing a first memory associated with an original electronic control unit for the vehicle, retrieving a configuration for the original electronic control unit from the first memory, associating the configuration with a vehicle identification number associated with the vehicle in a second memory remote from the vehicle and downloading the configuration from the second memory to a third memory associated with the replacement electronic control unit for the vehicle. | 04-11-2013 |
Patent application number | Description | Published |
20090299098 | Catalytic Metathesis of Secondary Amides - The invention provides methods and reagents for the metathesis of secondary amides via a transacylation mechanism employing catalytic quantities of an imide initiator and a Brønsted base. Equilibrium-controlled exchange between various amide reactant pairs is demonstrated for substrates bearing a variety of N-alkyl and N-aryl substituents. | 12-03-2009 |
20100222250 | POLY-BETA-PEPTIDES FROM FUNCTIONALIZED BETA-LACTAM MONOMERS AND ANTIBACTERIAL COMPOSITIONS CONTAINING SAME - Disclosed is a method of making β-polypeptides. The method includes polymerizing β-lactam-containing monomers in the presence of a base initiator and a co-initiator which is not a metal-containing molecule to yield the product β-polypeptides. Specifically disclosed are methods wherein the base initiator is potassium t-butoxide, lithium bis(trimethylsilyl)amide (LiN(TMS) | 09-02-2010 |
20100228024 | SEVEN-MEMBERED HETEROCYCLIC CARBENES AND THEIR METAL COMPLEXES - Disclosed are carbenes of the general formula: | 09-09-2010 |
20110127170 | Cobalt Oxyfluoride Catalysts For Electrolytic Dissociation Of Water - Disclosed are electrolysis catalysts formed from cobalt, oxygen and fluorine. They can be formed as a coating on an anode by conducting an electrolysis reaction using an electrolyte containing cobalt and fluoride. The catalysts will facilitate the conversion of water to hydrogen gas and oxygen gas, even at pH neutral/room temperature reaction conditions. The resulting hydrogen gas is a means of storing renewable energy for use in hydrogen powered vehicles or the like. | 06-02-2011 |
20110196127 | POLY-BETA-PEPTIDES FROM FUNCTIONALIZED BETA-LACTAM MONOMERS AND ANTIBACTERIAL COMPOSITIONS CONTAINING SAME - Disclosed is a method of making β-polypeptides. The method includes polymerizing β-lactam-containing monomers in the presence of a base initiator and a co-initiator which is not a metal-containing molecule to yield the product β-polypeptides. Specifically disclosed are methods wherein the base initiator is potassium t-butoxide, lithium bis(trimethylsilyl)amide (LiN(TMS) | 08-11-2011 |
20120305408 | Buffered Cobalt Oxide Catalysts - Disclosed are electrolysis catalysts formed from cobalt, oxygen and buffering electrolytes (e.g. fluoride). They can be formed as a coating on an anode by conducting an electrolysis reaction using an electrolyte containing cobalt and an anionic buffering electrolyte. The catalysts will facilitate the conversion of water to oxygen and hydrogen gas at a range of mildly acidic conditions. Alternatively, these anodes can be used with cathodes that facilitate other desirable reactions such as converting carbon dioxide to methanol. | 12-06-2012 |
20130004453 | NYLON-3 CO-POLYMERS AND SYNTHETIC LUNG SURFACTANT COMPOSITIONS CONTAINING SAME - Non-natural oligomers have recently shown promise as functional analogues of lung surfactant proteins Band C (SP-B and SP-C), two helical and amphiphilic proteins that are clitical for normal respiration. The generation of non-natural mimics of SP-B and SP-C has previously been restlicted to step-by-step, sequence-specific synthesis, which results in discrete oligomers that are intended to manifest specific structural attributes. Presented herein an alternative approach to SP-R mimicry that is based on sequence-random copolymers containing cationic and lipophilic subunits. These materials, members of the nylon-3 family, arc prepared by ling-opening polymelization of 13-lactams. The best of the nylon-3 polymers display promising in vitro surfactant activities in a mixed lipid film. Pulsating bubble surfactometry data indicate that films containing the most surface-active polymers attain adsorptive and dynamic-cycling properties that surpass those of discrete peptides intended to mimic SP-B. | 01-03-2013 |
20130206608 | Catalysts Having Mixed Metal Oxides - Disclosed are methods for generating oxygen via an electrolysis reaction. One places an anode and a cathode in aqueous solution, and uses an external source of electricity to drive the electrolysis reaction from the anode and cathode. The anode has at least three metal oxides, preferably with nickel oxide or cobalt oxide as at least one of the oxides. Also disclosed are electrodes designed for catalyzing oxygen consumption or formation reactions, where the electrodes have a mix of such three metal oxides. | 08-15-2013 |
20140235838 | SELECTIVE AEROBIC ALCOHOL OXIDATION METHOD FOR CONVERSION OF LIGNIN INTO SIMPLE AROMATIC COMPOUNDS - Described is a method to oxidize lignin or lignin sub-units. The method includes oxidation of secondary benzylic alcohol in the lignin or lignin sub-unit to a corresponding ketone in the presence of unprotected primarily aliphatic alcohol in the lignin or lignin sub-unit. The optimal catalyst system consists of HNO | 08-21-2014 |
20150144497 | BUFFERED COBALT OXIDE CATALYSTS - Disclosed are electrolysis catalysts formed from cobalt, oxygen and buffering electrolytes (e.g. fluoride). They can be formed as a coating on an anode by conducting an electrolysis reaction using an electrolyte containing cobalt and an anionic buffering electrolyte. The catalysts will facilitate the conversion of water to oxygen and hydrogen gas at a range of mildly acidic conditions. Alternatively, these anodes can be used with cathodes that facilitate other desirable reactions such as converting carbon dioxide to methanol. | 05-28-2015 |
20150231171 | NYLON-3 CO-POLYMERS AND SYNTHETIC LUNG SURFACTANT COMPOSITIONS CONTAINING SAME - Non-natural oligomers have recently shown promise as functional analogues of lung surfactant proteins B and C (SP-B and SP-C), two helical and amphiphilic proteins that are critical for normal respiration. The generation of non-natural mimics of SP-B and SP-C has previously been restricted to step-by-step, sequence-specific synthesis, which results in discrete oligomers that are intended to manifest specific structural attributes. Presented herein an alternative approach to SP-B mimicry that is based on sequence-random copolymers containing cationic and lipophilic subunits. These materials, members of the nylon-3 family, are prepared by ring-opening polymerization of β-lactams. The best of the nylon-3 polymers display promising in vitro surfactant activities in a mixed lipid film. Pulsating bubble surfactometry data indicate that films containing the most surface-active polymers attain adsorptive and dynamic-cycling properties that surpass those of discrete peptides intended to mimic SP-B. Attachment of an N-terminal octadecanoyl unit to the nylon-3 copolymers affords further improvements by reducing the percent surface area compression to reach low minimum surface tension. | 08-20-2015 |
20150259368 | SELECTIVE C-O BOND CLEAVAGE OF OXIDIZED LIGNIN AND LIGNIN-TYPE MATERIALS INTO SIMPLE AROMATIC COMPOUNDS - A method to cleave C—C and C—O bonds in β-O-4 linkages in lignin or lignin sub-units is described. The method includes oxidizing at least a portion of secondary benzylic alcohol groups in β-O-4 linkages in the lignin or lignin sub-unit to corresponding ketones and then leaving C—O or C—C bonds in the oxidized lignin or lignin sub-unit by reacting it with an organic carboxylic acid, a salt of an organic carboxylic acids, and/or an ester of an organic carboxylic acids. The method may utilize a metal or metal-containing reagent or proceed without the metal or metal-containing reagent. | 09-17-2015 |
20150263371 | Charge Transfer Mediator Based Systems for Electrocatalytic Oxygen Reduction - Disclosed are systems for the electrocatalytic reduction of oxygen, having redox mediator/redox catalyst pairs and an electrolyte solution in contact with an electrode. The redox mediator is included in the electrolyte solution, and the redox catalyst may be included in the electrolyte solution, or alternatively, may be in contact with the electrolyte solution. In one form a cobalt redox catalyst is used with a quinone redox mediator. In another form a nitrogen oxide redox catalyst is used with a nitroxyl type redox mediator. The systems can be used in electrochemical cells wherein neither the anode nor the cathode comprise an expensive metal such as platinum. | 09-17-2015 |
20150314272 | Conversion Of Alcohols To Alkyl Esters And Carboxylic Acids Using Heterogeneous Palladium-Based Catalysts - Disclosed are methods for synthesizing an ester or a carboxylic acid from an organic alcohol. To form the ester one reacts, in the presence of oxygen gas, the alcohol with methanol or ethanol. This reaction occurs in the presence of a catalyst comprising palladium and a co-catalyst comprising bismuth, tellurium, lead, cerium, titanium, zinc and/or niobium (most preferably at least bismuth and tellurium). Alternatively that catalyst can be used to generate an acid from that alcohol, when water is also added to the reaction mix. | 11-05-2015 |
20150322205 | POLY-BETA-PEPTIDES FROM FUNCTIONALIZED BETA-LACTAM MONOMERS AND ANTIBACTERIAL COMPOSITIONS CONTAINING SAME - Disclosed is a method of making β-polypeptides. The method includes polymerizing β-lactam-containing monomers in the presence of a base initiator and a co-initiator which is not a metal-containing molecule to yield the product β-polypeptides. Specifically disclosed are methods wherein the base initiator is potassium t-butoxide, lithium bis(trimethylsilyl)amide (LiN(TMS) | 11-12-2015 |
Patent application number | Description | Published |
20100239533 | Thraustochytrids, Fatty Acid Compositions, and Methods of Making and Uses Thereof - The present invention is directed to isolated thraustochytrid microorganisms as well as strains and mutants thereof. The invention is further directed to biomasses, microbial oils, compositions, cultures, methods of producing microbial oils, and methods of using the isolated thraustochytrids, biomasses, and microbial oils. | 09-23-2010 |
20110177031 | Eicosapentaenoic Acid-Producing Microorganisms, Fatty Acid Compositions, and Methods of Making and Uses Thereof - The present invention is directed to isolated microorganisms as well as strains and mutants thereof, biomasses, microbial oils, compositions, and cultures; methods of producing the microbial oils, biomasses, and mutants; and methods of using the isolated microorganisms, biomasses, and microbial oils. | 07-21-2011 |
20110295028 | Extraction of Lipid From Cells and Products Therefrom - The present invention relates to processes for obtaining a lipid from a cell by lysing the cell, contacting the cell with a base and/or salt, and separating the lipid. The present invention is also directed to a lipid prepared by the processes of the present invention. The present invention is also directed to microbial lipids having a particular anisidine value, peroxide value, and/or phosphorus content. | 12-01-2011 |
20120088831 | Thraustochytrids, Fatty Acid Compositions, and Methods of Making and Uses Thereof - The present invention is directed to isolated thraustochytrid microorganisms as well as strains and mutants thereof. The invention is further directed to biomasses, microbial oils, compositions, cultures, methods of producing microbial oils, and methods of using the isolated thraustochytrids, biomasses, and microbial oils. | 04-12-2012 |
20130190520 | EICOSAPENTAENOIC ACID-PRODUCING MICROORGANISMS, FATTY ACID COMPOSITIONS, AND METHODS OF MAKING AND USES THEREOF - The invention is directed to microbial oils containing omega-3 polyunsaturated fatty acids comprising docosahexaenoic acid, eicosapentaenoic acid, and optionally docosapentaenoic acid and dosage forms containing such oils. | 07-25-2013 |
20150237888 | EICOSAPENTAENOIC ACID-PRODUCING MICROORGANISMS, FATTY ACID COMPOSITIONS, AND METHODS OF MAKING AND USES THEREOF - The present invention is directed to isolated microorganisms as well as strains and mutants thereof, biomasses, microbial oils, compositions, and cultures; methods of producing the microbial oils, biomasses, and mutants; and methods of using the isolated microorganisms, biomasses, and microbial oils. | 08-27-2015 |
20150275244 | EICOSAPENTAENOIC ACID-PRODUCING MICROORGANISMS, FATTY ACID COMPOSITIONS, AND METHODS OF MAKING AND USES THEREOF - The invention is directed to microbial oils containing omega-3 polyunsaturated fatty acids comprising docosahexaenoic acid, eicosapentaenoic acid, and optionally docosapentaenoic acid and dosage forms containing such oils. | 10-01-2015 |
20150313861 | EICOSAPENTAENOIC ACID-PRODUCING MICROORGANISMS, FATTY ACID COMPOSITIONS, AND METHODS OF MAKING AND USES THEREOF - The present invention is directed to isolated microorganisms as well as strains and mutants thereof, biomasses, microbial oils, compositions, and cultures; methods of producing the microbial oils, biomasses, and mutants; and methods of using the isolated microorganisms, biomasses, and microbial oils. | 11-05-2015 |
Patent application number | Description | Published |
20140182277 | Electro-Hydraulic Steering System with Spool-Based Steering Event Detection - An electro-hydraulic steering system for an articulated machine includes an electrical circuit and a hydraulic circuit. The electrical circuit includes a controller, an electro-hydraulic valve assembly, and a spool position system. The hydraulic circuit includes a pump, at least one cylinder in selective fluid communication with the pump, and the valve assembly. The controller includes a computer-readable storage medium storing a steering system monitoring application which performs several steps. A desired flow of pressurized fluid to each cylinder and a desired spool position for the spool of the electro-hydraulic valve assembly, based upon the desired flow of pressurized fluid, are determined. The desired spool position and an actual spool position are compared to determine a spool-based flow error, which is summed over a period of time to determine a cumulative spool-based flow error. An event warning is issued when the cumulative spool-based flow error exceeds a threshold. | 07-03-2014 |
20140350794 | Managing Steering with Short From Battery to Ground - A redundancy system for a steering system having a primary controller and a primary power source is provided. The redundancy system may include a secondary controller coupled to a secondary power source and configured to manage control of the steering system, and an interface circuit disposed between at least a first node and a second node. The first node may be in electrical communication with the primary power source, and the second node may be in electrical communication with the secondary power source. The interface circuit may be configured to selectively engage a self-test of the primary power source and the secondary power source, isolate a short at the first node from the secondary power source, and isolate a short at the second node from the primary power source. | 11-27-2014 |
20150198183 | Failsafe Pilot Supply Selector Valve - A failsafe pilot selector valve may include at least one inlet port, a first outlet port, a second outlet port, and a biasing element. The failsafe pilot selector valve may have a first end position with the at least one inlet port in fluid communication with the first outlet port, a second end position with the at least one inlet port in fluid communication with the first outlet port, and an intermediate position between the first end position and the second end position with the at least one inlet port in fluid communication with the second outlet port. The biasing element may provide a biasing force to move the failsafe pilot selector valve to the first end position. The pilot selector valve can alternately provide pilot fluid to primary and redundant control elements of a redundantly controlled system in fluid communication with the outlet ports. | 07-16-2015 |