Lupi
Andrea Lupi, Octeville Sur Mer FR
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20080210334 | Filing Valve Having a Liquid Chamber, a Gas Chamber and a Medium Chamber, and Filling Machine Comprising the Same - Filling valve ( | 09-04-2008 |
20080283788 | Filling Valve Having a Three-Position Valve Rod - Filling valve ( | 11-20-2008 |
20090100799 | FILLING VALVE HAVING A LIQUID CHAMBER, A GAS CHAMBER AND A MEDIUM CHAMBER, AND FILLING MACHINE COMPRISING THE SAME - Filling valve ( | 04-23-2009 |
Cyril Lupi, Nantes FR
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20150125107 | MICROWAVE FREQUENCY COMPONENT CONTROLLED BY A SYSTEM OF SHIELDED COPLANAR ELECTRODES, AND CORRESPONDING MANUFACTURING METHOD - A microwave frequency component includes a thin layer of dielectric material arranged between an earth electrode and a control electrode controlling a microwave frequency electrical signal such that the earth electrode extends over a first face, called the lower face, of the thin layer of dielectric material, and the control electrode extends longitudinally over a second face, called the upper face, of the thin layer of dielectric material. The microwave frequency component is such that it includes a set of at least two shielded coplanar electrodes extending along the entire length of the control electrode, to each side of and at an equal distance from the control electrode. | 05-07-2015 |
Fabio Lupi, Albano Lazio IT
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20130110018 | HFCWO VEST | 05-02-2013 |
Giancarlo Lupi, Calcinaia IT
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20140323988 | STRUCTURE OF CONNECTOR FOR MEDICAL LINES - A connection device for a medical line including a first portion with a first passage duct, the first portion configured to couple with a first medical line to allow a flow of a fluid, and a second portion configured to couple with the first portion, and including a second passage duct that is arranged to connect with a second medical line. Furthermore, the connection device includes a releasable connection to connect the first portion and the second portion, from a coupled configuration, to a decoupled configuration. | 10-30-2014 |
Giuseppe Lupi, Gallicano - Luca IT
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20150336766 | MACHINE FOR THE FORMATION OF NUMBERED PACKS OF INTERLEAVED SHEETS OF PAPER - A machine for the formation of numbered packs of interleaved sheets of paper ( | 11-26-2015 |
Giuseppe Lupi, Gallicano (lucca) IT
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20120085856 | APPARATUS AND METHOD FOR EXCHANGE OF CORES IN A WINDING MACHINE - A method and an apparatus for exchange of cores in a machine for winding a continuous layer of paper ( | 04-12-2012 |
20150129708 | REWINDING MACHINE - A rewinding machine includes a drawing assembly ( | 05-14-2015 |
Katia Lupi, Genova IT
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20160085228 | METHOD AND SYSTEM FOR COLLECTING VIA A MES SYSTEM TIME-STAMPS OF WORKING-STATUSES - A method and a system collect via a MES, time-stamps of working-statuses of machines and operators, called also actors, for a calculation of a time-dependant component of OLE and OEE indicators in a manufacturing task. The method includes providing a token for assigning to an actor the responsibility of data provision, and defining two meta-statuses for a machine in a task, called operating and booked meta-status respectively. Each meta-status groups a set of machine statuses. A machine is defined to be in an operating meta-status when the machine is in a status engaged in the task and it is able to know and notify its own status. A machine is defined to be in a booked meta-status when the machine is in a status engaged in the task and it is unable to notify its own status. | 03-24-2016 |
Rosita Lupi, Legnano (mi) IT
Patent application number | Description | Published |
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20120157454 | ISOQUINOLIN-1 (2H) -ONE DERIVATIVES AS PARP-1 INHIBITORS - There are provided substituted isoquinolin-1(2H)-one derivatives which selectively inhibit the activity of poly (ADP-ribose) polymerase PARP-1 with respect to poly (ADP-ribose) polymerase PARP-2. The compounds of the present invention are therefore useful in treating diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing pharmaceutical compositions comprising these compounds. A screening method for the identification of compounds capable of binding several PARP proteins, as well the probes used in such method, are further objects of the invention. | 06-21-2012 |
20140045846 | ISOQUINOLIN-1(2H)-ONE DERIVATIVES AS PARP-1 INHIBITORS - There are provided substituted isoquinolin-1(2H)-one derivatives which selectively inhibit the activity of poly (ADP-ribose) polymerase PARP-1 with respect to poly (ADP-ribose) polymerase PARP-2. The compounds of the present invention are therefore useful in treating diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing pharmaceutical compositions comprising these compounds. A screening method for the identification of compounds capable of binding several PARP proteins, as well the probes used in such method, are further objects of the invention. | 02-13-2014 |
Rosita Lupi, Legnano IT
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20100022532 | USE OF A KINASE INHIBITOR FOR THE TREATMENT OF PARTICULAR RESISTANT TUMORS - The invention provides low molecular weight compounds, namely 1H-thieno[2,3-c]pyrazoles, showing a high affinity for the ATP pocket of ABL tyrosine kinase. These compounds are thus ATP-competitive tyrosine kinase inhibitors displaying a significant inhibitory potency also, and in particular, towards BCR-ABL inhibitor-resistant T315I ABL mutants. The compounds of the invention find a useful application in the treatment of BCR-ABL inhibitor-resistant ABL-mediated diseases, such as Imatinib-resistant chronic myelogenous leukemia. Moreover, the invention provides a screening method for the identification of compounds capable of binding the ATP pocket of a kinase protein, in particular of the T315I mutant ABL kinase. | 01-28-2010 |
Rosita Lupi, Milan IT
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20100035876 | Use of a Kinase Inhibitor for the Treatment of Particular Resistant Tumors - The invention provides low molecular weight compounds, namely tetrahydropyrrolo[3,4-c]pyrazoles, showing a high affinity for the ATP pocket of ABL tyrosine kinase. These compounds are thus ATP-competitive tyrosine kinase inhibitors displaying a significant inhibitory potency also, and in particular, towards BCR-ABL inhibitor-resistant T315I ABL mutants. The compounds of the invention find a useful application in the treatment of BCR-ABL inhibitor-resistant ABL-mediated diseases, such as Imatinib-resistant chronic myelogenous leukemia. Moreover, the invention provides a screening method for the identification of compounds capable of binding the ATP pocket of a kinase protein, in particular of the T315I mutant ABL kinase. | 02-11-2010 |
Vittoria Lupi, Milan (it) IT
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20150051154 | ALKYLATING AGENTS - The present invention relates to a novel class of alkylating agents comprising a thieno-indole moiety linked to a DNA-binding moiety, which have cytotoxic activity and are useful in treating diseases such as cancer, cellular proliferation disorders and viral infections. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising them and methods of treating diseases utilizing such compounds or the pharmaceutical composition containing them. The invention also relates to the use of this novel class of alkylating agents in the preparation of conjugates. | 02-19-2015 |
20150080316 | FUNCTIONALIZED THIENO-INDOLE DERIVATIVES FOR THE TREATMENT OF CANCER - The invention relates to new functionalized thieno-indole derivatives of formula (I) or (II) which have cytotoxic activity and are useful in treating diseases such as cancer and cellular proliferation disorders. The invention also relates to the use of these functionalized thieno-indole derivatives in the preparation of conjugates. Formula (I) or (II) wherein R | 03-19-2015 |
Vittoria Lupi, Milan IT
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20100034837 | ANTHRACYCLINE DERIVATIVE CONJUGATES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOR COMPOUNDS - The present invention relates to conjugates of therapeutically useful anthracyclines with carriers such as polyclonal and monoclonal antibodies, proteins or peptides of natural or synthetic origin; methods for their preparation, pharmaceutical composition containing them and use thereof in treating certain mammalian tumors. | 02-11-2010 |
20120130059 | ANTHRACYCLINE DERIVATIVE CONJUGATES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOR COMPOUNDS - The present invention relates to conjugates of therapeutically useful anthracyclines with carriers such as polyclonal and monoclonal antibodies, proteins or peptides of natural or synthetic origin; methods for their preparation, pharmaceutical composition containing them and use thereof in treating certain mammalian tumors. | 05-24-2012 |
20120142906 | PROCESS FOR THE PREPARATION OF MORPHOLINYL ANTHRACYCLINE DERIVATIVES - The present invention provides a process for the preparation of a morpholinyl anthracycline derivative in good yields and purity, including 3′-deamino-3″-4′-anhydro-[2″(S)-methoxy-3″(R)-hydroxy-4″-morpholinyl]doxorubicin (1). | 06-07-2012 |
20150051380 | ANTHRACYCLINE DERIVATIVE CONJUGATES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOR COMPOUNDS - The present invention relates to conjugates of therapeutically useful anthracyclines with carriers such as polyclonal and monoclonal antibodies, proteins or peptides of natural or synthetic origin; methods for their preparation, pharmaceutical composition containing them and use thereof in treating certain mammalian tumors. | 02-19-2015 |
20160075730 | NEW MORPHOLINYL ANTHRACYCLINE DERIVATIVES - The present invention relates to new morpholinyl anthracycline derivatives which have cytotoxic activity and are useful in treating diseases such as cancer, cellular proliferation disorders and viral infections. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising them and methods of treating diseases utilizing such compounds or the pharmaceutical compositions containing them. | 03-17-2016 |