Patent application number | Description | Published |
20090324556 | Mutated immunogenic peptides derived from R9M, polynucleotides coding for same and therapeutic uses thereof - The invention concerns the optimization of the wild R9M peptide and the use of the resulting peptides for therapeutic vaccination and/or preventive vaccination against leukaemia in humans. More particularly, the invention concerns mutated immunogenic peptides derived from the human TEL/AML1 fusion protein comprising the wild R9M peptide sequence Arg-Ile-Ala-Glu-Czs-Ile-Leu-Gly-Met. The invention also concerns polynucleotides coding for the mutated R9M immunogenic peptides, cellular expression vectors comprising nucleic acid sequences expressing the mutated R9M immunogenic peptides and polyclonal or monoclonal antibodies capable of being fixed on at least one of said peptides/polynucleotides. The invention further concerns the use of said peptides, polynucleotides and/or antibodies for preparing vaccines, anti-tumoral medicines and compositions and for in vitro and in vivo stimulation of the immune response in humans. | 12-31-2009 |
20100221820 | Use of triplex structure DNA in transferring nucleotide sequences - The invention concerns a recombinant vector characterised in that it comprises a polynucleotide comprising a central initiation cis-active region (cPPT) and a termination cis-active region (CTS), said regions being of retroviral or retroviral-like origin, said vector further comprising a predetermined nucleotide sequence (transgene or nucleotide sequence of interest) and retranscription regulating, expressing and packaging signals of retroviral or retroviral-like origin. | 09-02-2010 |
20130157357 | LENTIVIRAL VECTORS FOR THE PREPARATION OF IMMUNOTHERAPEUTICAL COMPOSITIONS - The invention relates to an immunogenic composition comprising a recombinant vector characterized in that it comprises a polynucleotide comprising the cis-acting central initiation region (cPPT) and the cis-acting termination region (CTS), these regions being of retroviral or retroviral-like origin, said vector comprising in addition a defined nucleotide sequence (transgene or sequence of interest) and regulatory signals of retrotranscription, expression and encapsidation of retroviral or retroviral-like origin, wherein the composition is capable of inducing or of stimulating a cell-mediated response for instance a CTL (Cytotoxic T Lymphocytes) response or a CD4 response, against one or several epitopes encoded by the transgene sequence present in the vector. | 06-20-2013 |
Patent application number | Description | Published |
20110119328 | Load Balancing In A Distributed Computing Environment - Systems, methods, and computer storage media for load balancing at a client device in a distributed computing environment based on a dynamic validity duration and utilization metrics of one or more data stores are provided. The client device selects a data store from a plurality of data stores that each maintains a copy of a datum. The selection of data stores by a client is based on utilization metrics of the data stores. The utilization metrics are stored at the client. A data store determines if a request for a particular datum may be fulfilled within a validity period associated with a request from the client. The validity period is dynamically changed by the client across multiple requests to aid in the load balancing process. Additionally, a gossip protocol may be used to propagate utilization metrics of a plurality of data stores across the system. | 05-19-2011 |
20120060072 | ERASURE CODING IMMUTABLE DATA - Embodiments of the present invention relate to systems, methods and computer storage media for erasure coding data in a distributed computing environment. A sealed extent is identified that is comprised of two or more data blocks and two or more index blocks. The sealed extent is optimized for erasure coding by grouping the two or more data blocks within the optimized sealed extent together and grouping the two or more index blocks within the optimized sealed extent together. The optimized extent may also be erasure coded, which includes creating data fragments and coding fragments. The data fragments and the coding fragments may also be stored in the distributed computing environment. Additional embodiments include monitoring statistical information to determine if replication, erasure coding or a hybrid storage plan should be utilized. | 03-08-2012 |
20130054549 | CLOUD DATA STORAGE USING REDUNDANT ENCODING - Cloud data storage systems, methods, and techniques partition system data symbols into predefined-sized groups and then encode each group to form corresponding parity symbols, encode all data symbols into global redundant symbols, and store each symbol (data, parity, and redundant) in different failure domains in a manner that ensures independence of failures. In several implementations, the resultant cloud-encoded data features both data locality and ability to recover up to a predefined threshold tolerance of simultaneous erasures (unavailable data symbols) without any information loss. In addition, certain implementations also feature the placement of cloud-encoded data in domains (nodes or node groups) to provide similar locality and redundancy features simultaneous with the recovery of an entire domain of data that is unavailable due to software or hardware upgrades or failures. | 02-28-2013 |
20140380125 | ERASURE CODING ACROSS MULTIPLE ZONES - In various embodiments, methods and systems for erasure coding data across multiple storage zones are provided. This may be accomplished by dividing a data chunk into a plurality of sub-fragments. Each of the plurality of sub-fragments is associated with a zone. Zones comprise buildings, data centers, and geographic regions providing a storage service. A plurality of reconstruction parities is computed. Each of the plurality of reconstruction parities computed using at least one sub-fragment from the plurality of sub-fragments. The plurality of reconstruction parities comprises at least one cross-zone parity. The at least one cross-zone parity is assigned to a parity zone. The cross-zone parity provides cross-zone reconstruction of a portion of the data chunk. | 12-25-2014 |
20140380126 | ERASURE CODING ACROSS MULTIPLE ZONES AND SUB-ZONES - In various embodiments, methods and systems for erasure coding data across multiple storage zones are provided. This may be accomplished by dividing a data chunk into a plurality of sub-fragments. Each of the plurality of sub-fragments is associated with a zone. Zones comprise buildings, data centers, and geographic regions providing a storage service. A plurality of reconstruction parities is computed. Each of the plurality of reconstruction parities computed using at least one sub-fragment from the plurality of sub-fragments. The plurality of reconstruction parities comprises at least one cross-zone parity. The at least one cross-zone parity is assigned to a parity zone. The cross-zone parity provides cross-zone reconstruction of a portion of the data chunk. | 12-25-2014 |
Patent application number | Description | Published |
20080249755 | Modeling Cerebral Aneurysms in Medical Images - Methods and systems for modeling cerebral aneurysm and their incoming and outgoing vessels from 3D image data are disclosed. Aneurysms and vessels are segmented from their background using a graph-cuts method. Begin and end of vessels are determined. Construction of a centerline of the incoming and outgoing vessels using a measure of vesselness in calculating a minimum cost path in a graph with nodes being representation of pixels is also disclosed. Vessel surface models are constructed from sub-voxel cross-sectional segmentation. The interpolation of vessels inside an aneurysm based on smooth continuity is disclosed. Selection of endo-vascular stents based on interpolation results is also provided. | 10-09-2008 |
20090278846 | SYSTEM AND METHOD FOR GEOMETRIC MODELING OF TUBULAR STRUCTURES - A method for extracting a centerline of a tubular structure in a digital medical image includes providing a 3-dimensional (3D) digitized medical image having a segmented tubular structure, finding a path in the image between a starting point and every other point in the tubular structure that minimizes an accumulative cost function, wherein the minimum accumulative cost φ(x) at a point x is a minimum of (φ(x′)+P | 11-12-2009 |
20130246034 | Method and System for Non-Invasive Functional Assessment of Coronary Artery Stenosis - A method and system for non-invasive assessment of coronary artery stenosis is disclosed. Patient-specific anatomical measurements of the coronary arteries are extracted from medical image data of a patient acquired during rest state. Patient-specific rest state boundary conditions of a model of coronary circulation representing the coronary arteries are calculated based on the patient-specific anatomical measurements and non-invasive clinical measurements of the patient at rest. Patient-specific rest state boundary conditions of the model of coronary circulation representing the coronary arteries are calculated based on the patient-specific anatomical measurements and non-invasive clinical measurements of the patient at rest. Hyperemic blood flow and pressure across at least one stenosis region of the coronary arteries are simulated using the model of coronary circulation and the patient-specific hyperemic boundary conditions. Fractional flow reserve (FFR) is calculated for the at least one stenosis region based on the simulated hyperemic blood flow and pressure. | 09-19-2013 |
20140058715 | Method and System for Non-Invasive Functional Assessment of Coronary Artery Stenosis - A method and system for non-invasive assessment of coronary artery stenosis is disclosed. Patient-specific anatomical measurements of the coronary arteries are extracted from medical image data of a patient acquired during rest state. Patient-specific rest state boundary conditions of a model of coronary circulation representing the coronary arteries are calculated based on the patient-specific anatomical measurements and non-invasive clinical measurements of the patient at rest. Patient-specific rest state boundary conditions of the model of coronary circulation representing the coronary arteries are calculated based on the patient-specific anatomical measurements and non-invasive clinical measurements of the patient at rest. Hyperemic blood flow and pressure across at least one stenosis region of the coronary arteries are simulated using the model of coronary circulation and the patient-specific hyperemic boundary conditions. Fractional flow reserve (FFR) is calculated for the at least one stenosis region based on the simulated hyperemic blood flow and pressure. | 02-27-2014 |
Patent application number | Description | Published |
20110149732 | Method of improving quality of service for voice calls handled by a network element - In one embodiment, the method includes throttling, at the network element, a data rate of data traffic sent by the network element based on a quality of service for at least one voice call handled by the network element. | 06-23-2011 |
20110307354 | METHOD AND APPARATUS FOR RECOMMENDING APPLICATIONS TO MOBILE USERS - Various deficiencies in the prior art are addressed by embodiments for recommending applications to users. A method and apparatus are provided for selecting an application to recommend to a user based on user profile information associated with the user and application profile information associated with the application, and propagating recommended application information toward a user device of the user, where the recommended application information includes an application executable of the recommended application. A method and apparatus are provided for receiving, at a user device, recommended application information comprising an application executable of an application recommended for a user of the user device, and automatically installing the application executable on the user device. | 12-15-2011 |
20120078683 | METHOD AND APPARATUS FOR PROVIDING ADVICE TO SERVICE PROVIDER - A method for providing advice to a service provider includes; a) accessing customer, network, and service data stored in disparate data sources, the data relating to services provided to customers by a service provider over a network infrastructure, a virtualization platform presenting the disparate data in a common logical view; b) processing the data in an analytics platform using a service advisor algorithm to form conclusions and predictions regarding management of customer churn and generate advice; and c) formulating results from the processing to enable the service provider to consider the data, conclusions, predictions, and advice in relation to reduction of customer churn. The service advisor algorithm may also be used for personalization of service provided to customers, targeted marketing of services to customers or non-customers, and management of the network infrastructure. An apparatus for providing advice to a service provider includes the virtualization and analytics platforms. | 03-29-2012 |
20120170932 | Apparatus And Method For Scheduling On An Optical Ring Network - An example method includes receiving at a scheduling server status information concerning at least one transmit queue for a plurality of optical pass-through switches (OptSws). A schedule for transmissions to take place is determined based on the status information for the OptSws. A control message is forwarded to the plurality of OptSws in order that the schedule may be implemented. In an embodiment, a schedule is determined for a wavelength available to transmit a transmission by removing unsupportable transmissions from a candidate transmission list, determining a first transmission that is the one of the transmissions of the candidate transmission list which most preferably satisfies a given parameter, updating a usage list to reflect determination of the first transmission; and replacing the candidate transmission list with the residue set of the first transmission. The usage list reflects transmissions determined by the scheduler. | 07-05-2012 |
20130066933 | METHOD AND APPARATUS FOR DERIVING COMPOSITE TIE METRIC FOR EDGE BETWEEN NODES OF A TELECOMMUNICATION CALL GRAPH - A method for deriving a composite tie metric for an edge between nodes of a telecommunication call graph includes receiving descriptive data with original values for descriptive attributes associated with a telecommunication call graph formed by edges between nodes. Each edge relates to two nodes. Each original value relates to an edge and a descriptive attribute forming an edge-attribute pair for the corresponding original value. The descriptive data is stored in a local storage device. Scaling factors for each descriptive attribute are determined taking into account a distribution of the original values for the corresponding descriptive attribute and a common base for the descriptive attributes. Weighting factors are determined for each descriptive attribute. The composite tie metric is computed for an edge based on the original value, scaling factor, and weighting factor for the descriptive attributes. | 03-14-2013 |
20130343224 | Method And Apparatus For Providing A Non-Overlapping Ring-Mesh Network Topology - Various embodiments provide a method and apparatus of providing a non-overlapping ring-mesh network topology which reduces costs (e.g., the number of network links) while providing resiliency to failure and meeting QoS requirements (e.g., network delay attributed to traversing the network architecture). In particular, a set of target nodes belonging to a cluster are connected through N rings. Each node is member of all N rings and no link between nodes in a ring is duplicated in another ring. | 12-26-2013 |
20140119522 | SYSTEM AND METHOD FOR GENERATING SUBSCRIBER CHURN PREDICTIONS - A system and method for generating a subscriber churn prediction includes receiving call detail records from a network operator detailing communication between subscribers of the network operator and determining tie-strengths between subscribers based on the call detail records. The system and method further includes generating a net churn influence accumulated at each subscriber from the tie-strengths by propagating churner influence between subscribers due to churn events. | 05-01-2014 |
20140122594 | METHOD AND APPARATUS FOR DETERMINING USER SATISFACTION WITH SERVICES PROVIDED IN A COMMUNICATION NETWORK - A processing platform comprises at least one processing device having a processor coupled to a memory. The processing platform is configured to identify particular metrics that influence user satisfaction with communication services provided by a communication network, and to generate at least one model that relates the identified metrics to user satisfaction scores. The processing platform may be further configured to generate at least one user satisfaction score for a plurality of users of the communication services given specified values of the identified metrics for only a subset of those users. For example, separate user satisfaction scores may be generated for respective ones of the users. Additionally or alternatively, a single per-segment user satisfaction score may be generated for each of one or more segments of multiple users. | 05-01-2014 |
20150032875 | ADAPTIVE POLLING OF INFORMATION FROM A DEVICE - A capability is provided for adaptive polling of a device based on a set of polling control regions configured to control polling of the device. The set of polling control regions is defined based on at least one of a set of control parameters and non-parametric control information. A transition within the set of polling control regions is determined based on a current polling control region and a target polling control region that is determined based on input information received while in the current polling control region. The input information may include at least one of values of one or more parameters in the set of parameters and non-parametric input information. The transition may include remaining in the current polling control region or transitioning to a new polling control region. The transition may be performed based on a rapid up controlled down (RUCD) transition scheme. | 01-29-2015 |
20150180796 | NETWORK RESOURCE MANAGEMENT FOR PARALLEL COMPUTING - An illustrative example computing system includes a parallel computing controller configured to communicate control information with a plurality of computing nodes over a virtual private network. A cloud computing controller is configured to receive a communication from the parallel computing controller. Based at least in part on the received communication, the cloud computing controller allocates cloud computing resources to facilitate data traffic communication involving at least one of the plurality of computing nodes. | 06-25-2015 |
20150222519 | ADAPTIVE POLLING OF INFORMATION FROM A DEVICE - A capability is provided for adaptive polling of a device based on a set of polling control regions configured to control polling of the device. The set of polling control regions is defined based on at least one of a set of control parameters and non-parametric control information. A transition within the set of polling control regions is determined based on a current polling control region and a target polling control region that is determined based on input information received while in the current polling control region. The input information may include at least one of values of one or more parameters in the set of parameters and non-parametric input information. The transition may include remaining in the current polling control region or transitioning to a new polling control region. The transition may be performed based on a rapid up controlled down (RUCD) transition scheme. | 08-06-2015 |
20150278823 | CLASSIFICATION OF DEVICE PROBLEMS OF CUSTOMER PREMISES DEVICES - A capability for classifying a device problem of a customer premises device of a customer is presented. The capability for classifying a device problem of a customer premises device of a customer may include receiving customer trouble ticket information of a trouble ticket associated with a customer, receiving customer device measurement information for a customer premises device of the customer, and classifying a device problem of the customer premises device based on text mining of the customer trouble ticket information and based on the customer device measurement information. | 10-01-2015 |
Patent application number | Description | Published |
20110250650 | LENTIVIRAL VECTORS FOR THE PREPARATION OF IMMUNOTHERAPEUTICAL COMPOSITIONS - The invention relates to an immunogenic composition comprising a recombinant vector characterized in that it comprises a polynucleotide comprising the cis-acting central initiation region (cPPT) and the cis-acting termination region (CTS), these regions being of retroviral or retroviral-like origin, said vector comprising in addition a defined nucleotide sequence (transgene or sequence of interest) and regulatory signals of retrotranscription, expression and encapsidation of retroviral or retroviral-like origin, wherein the composition is capable of inducing or of stimulating a cell-mediated response for instance a CTL (Cytotoxic T Lymphocytes) response or a CD4 response, against one or several epitopes encoded by the transgene sequence present in the vector. | 10-13-2011 |
20120095083 | USE OF TRIPLEX STRUCTURE DNA IN TRANSFERRING NUCLEOTIDE SEQUENCES - A method to induce an immune response in a host in need thereof, comprises administering to the host, recombinant lentiviral vector particles comprising:
| 04-19-2012 |
20120252113 | USE OF TRIPLEX STRUCTURE DNA IN TRANSFERRING NUCLEOTIDE SEQUENCES - The invention concerns a recombinant vector characterized in that it comprises a polynucleotide comprising a central initiation cis-active region (cPPT) and a termination cis-active region (CTS), the regions being of retroviral or retroviral-like origin, and the vector further comprising a predetermined nucleotide sequence (transgene or nucleotide sequence of interest) and retrotranscription regulating, expressing, and packaging signals of retroviral or retroviral-like origin. | 10-04-2012 |
20120252114 | USE OF TRIPLEX STRUCTURE DNA IN TRANSFERRING NUCLEOTIDE SEQUENCES - The invention concerns a recombinant vector characterized in that it comprises a polynucleotide comprising a central initiation cis-active region (cPPT) and a termination cis-active region (CTS), the regions being of retroviral or retroviral-like origin, and the vector further comprising a predetermined nucleotide sequence (transgene or nucleotide sequence of interest) and retrotranscription regulating, expressing, and packaging signals of retroviral or retroviral-like origin. | 10-04-2012 |