Patent application number | Description | Published |
20110312056 | Plasma Membrane Isolation - The present invention relates to a population of monodisperse magnetic nanoparticles with a diameter between 1 and 100 nm which are coated with a layer with hydrophilic end groups. Herein the layer with hydrophilic end groups comprises an inner layer of monosaturated and/or monounsaturated fatty acids bound to said nanoparticles and bound to said fatty acids, an outer layer of a phospholipid conjugated to a monomethoxy polyethyleneglycol (PEG) comprising a hydrophilic end group, | 12-22-2011 |
20120237526 | BACE1 INHIBITORY ANTIBODIES - The present invention relates to antibodies with a specificity for BACE1. More specifically, the invention provides monoclonal antibodies that bind to BACE1 and are capable of inhibiting the activity of BACE1 and methods producing these antibodies. The antibodies can be used for research and medical applications. Specific applications include the use of BACE1-specific antibodies for the treatment of Alzheimer's disease. | 09-20-2012 |
20120276076 | ARF6 AS A NEW TARGET FOR TREATING ALZHEIMER'S DISEASE - The invention relates to the field of disorders of the peripheral or central nervous system, in particular, Alzheimer's disease, and the prevention and/or treatment thereof. In particular, the invention relates to ARF6 and/or ARF6 effector proteins as new targets in Alzheimer's disease, and based thereon, screening methods for compounds that reduce amyloid beta peptide formation in mammalian cells by affecting ARF6-mediated endosomal sorting. | 11-01-2012 |
20140118524 | Method And Apparatus For The Imaging Of A Labeled Biological Sample - A method and apparatus for the imaging of a labeled biological sample. The method comprises illuminating the labeled biological sample, generating members of a time series of images if the labeled biological sample, generating a plurality of difference images between later members of the time series of images of earlier members of the time series of images and combining the plurality of difference images to generate a final image of the labeled biological sample. | 05-01-2014 |
Patent application number | Description | Published |
20100298626 | BONE CONDUCTION DEVICE HAVING A MULTILAYER PIEZOELECTRIC ELEMENT - A bone conduction device comprising a multilayer piezoelectric element. The multilayer piezoelectric element comprises two stacked piezoelectric layers, and a flexible passive layer disposed between the piezoelectric layers. The device also comprises a mass component attached to the multilayer piezoelectric element; and a coupling attached to the multilayer piezoelectric element configured to transfer mechanical forces generated by the multilayer piezoelectric element and the mass component to a recipient's skull. | 11-25-2010 |
20130035744 | IMPLANTABLE MICROPHONE FOR AN IMPLANTABLE HEARING PROSTHESIS - An implantable microphone for a hearing prosthesis. The microphone comprises: a housing having a diaphragm chamber formed therein, and an aperture extending from the exterior surface of the housing to the chamber; a diaphragm disposed on the exterior of the housing so as to seal the aperture, and configured to vibrate in response to sound signals; a sensor positioned adjacent an end of the chamber opposing the diaphragm, and configured to detect vibration of the diaphragm, and to generate electrical signals based thereon; and a stiffening material substantially filling the regions of the housing external to the sensor and the diaphragm such that that air gaps within the filled regions of the housing are substantially eliminated, wherein the stiffening material has an elastic modulus that enables the housing to substantially resist deformation there of in response to body-noise. | 02-07-2013 |
20130096366 | IMPLANTABLE MEDICAL DEVICE - An implant configured for secured implantation into a recess formed in a recipient's bone and to removably retain a separate component in a compartment thereof such that the separate component is removable from the implant without removing the implant from the bone. | 04-18-2013 |
20130150657 | IMPLANTABLE COMPONENT OF A HEARING PROSTHESIS - A hearing prosthesis including an implantable component including a vibrator portion configured to vibrate in response to a sound signal to evoke a hearing precept and a screw portion configured to removably attach the implantable component to a recipient, wherein the vibratory portion is rigidly adhered to the screw portion. | 06-13-2013 |
Patent application number | Description | Published |
20080287697 | Process for preparing fatty acid esters from pre-treated glyceride oils - This invention provides a process for forming fatty acid esters of C | 11-20-2008 |
20090158640 | PROCESS FOR PRODUCING BIODIESEL WITH IMPROVED FILTRATION CHARACTERISTICS AND BIODIESEL THUS PRODUCED - A process for the production and purification of fatty acid esters of lower alkyl alcohols with improved filtration characteristics comprising the steps of: a) transesterifying a mixture of fatty acid esters of glycerol with a lower alkyl alcohol while using an alkaline catalyst; b) separating the reaction mixture resulting from step (a) into a glycerol phase and a fatty acid lower alkyl ester phase; c) inactivating the catalytic intermediates present in said fatty acid lower alkyl ester phase; d) removing the lower alkyl alcohol from the mixture resulting from step (c) by evaporation at reduced pressure to a value of less than 2% by weight; e) treating the evaporation residue resulting from step (d) with water; and f) isolating the fatty acid esters of lower alcohols by drying the product resulting from step (e); and biodiesel containing FAME produced according to this process. | 06-25-2009 |
20100047884 | Method for Producing Biodiesel - The invention relates to the utilisation of fatty materials with substantial free fatty acid content in the production of biodiesel by the use of microbial enzymes that are effective in a solvent-free process for the production of esters of fatty acids and C | 02-25-2010 |
20100240917 | Enzymatic oil recuperation process - A process for the recuperation of acylglycerols or acylglycerols containing free fatty acids from gums, present as aqueous emulsions, said gums being obtained by subjecting triglyceride oil to one or more degumming processes, said recuperation process comprising the steps of: subjecting said gums to enzymatic hydrolysis catalysed by one or more enzymes with phospholipase activity; allowing said gums to separate into two or more phases, said two or more phases including at least an oily phase and an aqueous phase; and recuperating said oily phase comprising acylglycerols or acylglycerols containing free fatty acids; wherein said enzymatic hydrolysis is accelerated by adding at least part of the one or more enzymes with phospholipase activity to at least part of the water used in the recuperation and/or at least one degumming process; and/or at least part of said triglyceride oils treated in said degumming process; and/or by facilitating mixing at least part of said one or more enzymes with phospholipase activity into said gums by increasing the triglyceride oil content of said gums; and an oil obtained by this process. | 09-23-2010 |
Patent application number | Description | Published |
20080219080 | Memory Device with Reduced Standby Power Consumption and Method for Operating Same - Disclosed herein are memory devices comprising a plurality of memory cells to which a standby voltage is to be supplied during standby mode to avoid loss of data, and methods of operating said memory devices, the methods comprising: (a) determining an actual value of a bit integrity parameter of the memory cells; (b) comparing said actual value with a predetermined minimal value of the bit integrity parameter which takes into account possible variations in cell properties as a result of process variations; and (c) adjusting the standby voltage towards a more optimal value based on the result of the comparison in such a way that said bit integrity parameter determined for said more optimal value of the standby voltage approaches the predetermined minimal value. The circuitry for measuring the bit integrity parameter preferably comprises a plurality of replica test cells which are added to the memory matrix. | 09-11-2008 |
20090091485 | Asynchronous Sigma Delta Analog To Digital Converter Using A Time To Digital Converter - This disclosure relates to analog to digital conversion using irregular sampling. | 04-09-2009 |
20090251349 | MULTIPLE OUTPUT TIME-TO-DIGITAL CONVERTER - A multiple output time-to-digital converter (TDC) and an Analog-to-Digital Converter (ADC) incorporating the multiple output TDC is dislosed. | 10-08-2009 |
20110063934 | MEMORY CIRCUIT WITH MULTI-SIZED SENSE AMPLIFIER REDUNDANCY - A memory circuit with multi-sized sense amplifier redundancy is disclosed. In one aspect, the circuit includes sense amplifiers connected to differential bit-lines and configured to amplify a voltage difference sensed on the differential bit-lines. The sense amplifiers include a first set of smaller sense amplifiers and a second set of larger sense amplifiers redundantly arranged to the first set to form redundant groups which each contain one smaller sense amplifiers and one larger sense amplifiers. The larger sense amplifiers have a failure rate lower than the smaller sense amplifiers. The circuit also includes calibration circuitry connected to enable and disable nodes of each of the sense amplifiers and configured to select for each redundant group either the smaller sense amplifier of the first set or, if the smaller sense amplifier fails, the larger sense amplifier of the second set. | 03-17-2011 |
20110068966 | Asynchronous Sigma Delta Analog to Digital Converter Using a Time to Digital Converter - This disclosure relates to analog to digital conversion using irregular sampling. A method may include combining an analog signal with a feedback signal into a combined signal, filtering the combined signal using a digital noise shaping filter into a combined noise shaped signal, modulating the combined noise shaped signal into a modulated signal, generating samples of the modulated signal, and reconstructing as a digital signal the analog signal from the samples of the modulated signal. | 03-24-2011 |
20110193731 | Analog-to-digital converter using oscillators - An apparatus is provided which has a first analog input and a second analog input. In a particular implementation, the first analog input is coupled to a first controllable oscillator and the second analog input is coupled to a second controllable oscillator. First and second digital output signals generated based on output oscillations from the first controllable oscillator and the second controllable oscillator are combined. | 08-11-2011 |
20110305099 | HIERARCHICAL BUFFERED SEGMENTED BIT-LINES BASED SRAM - A semiconductor memory device is disclosed. In one aspect, the device includes memory blocks with memory cells connected to a local bit-line, each local bit-line being connectable to a global bit-line for memory readout. There are also pre-charging circuitry for pre-charging the bit-lines and a read buffer for discharging the global bit-line during a read operation. The local bit-lines are pre-charged to a predetermined first voltage substantially lower than the supply voltage (VDD) of the memory device. A segment buffer is provided between each local bit-line and an input node of the respective read buffer. The segment buffer activates the read buffer during the read operation upon occurrence of a discharge on the connected local bit-line. | 12-15-2011 |
20120063211 | METHOD FOR IMPROVING WRITABILITY OF SRAM MEMORY - A method for improving writability of an SRAM cell is disclosed. In one aspect, the method includes applying a first voltage higher than the global ground voltage and a third voltage higher than the global supply voltage to the ground supply nodes of the invertors of the SRAM cell, pre-charging one of the complementary bitlines to the global ground voltage, and applying a second voltage higher than the global supply voltage to the access transistors during a write operation to the SRAM cell. | 03-15-2012 |
20120063252 | VARIABILITY RESILIENT SENSE AMPLIFIER WITH REDUCED ENERGY CONSUMPTION - An ultra low power sense amplifier circuit for amplifying a low swing input signal to a full swing output signal is disclosed. In one aspect, the amplifier circuit includes a first amplifier stage for pre-amplifying the input signal to an intermediate signal on its internal nodes, a second amplifier stage for amplifying the intermediate signal to the output signal, and a control circuit for sequentially activating the first and second amplifier. The first amplifier has a capacitor for limiting energy consumption and two upsized PMOS transistors without NMOS transistors. | 03-15-2012 |
20140071737 | LOCAL WRITE AND READ ASSIST CIRCUITRY FOR MEMORY DEVICE - A memory device having complementary global and local bit-lines, the complementary local bit-lines being connectable to the complementary global bit-lines by means of a local write receiver which is configured for creating a full voltage swing on the complementary local bit lines from a reduced voltage swing on the complementary global bit lines. The local write receiver comprises a connection mechanism for connecting the local to the global bit-lines and a pair of cross-coupled inverters directly connected to the complementary local bit lines for converting the reduced voltage swing to the full voltage swing on the complementary local bit lines. | 03-13-2014 |
Patent application number | Description | Published |
20090239280 | METHOD FOR PRODUCING METAL NANOPARTICLES - This invention provides a method for producing a composition comprising colloidal nanoparticles of metals including silver, gold, zinc, mercury, copper, palladium, platinum, or bismuth, by contacting a metal or metal compound with bacteria. An embodiment of the method comprises a step of incubating probiotic bacteria with an aqueous solution comprising at least 4 mM of a silver or gold salt. A resulting nanosilver-containing composition is useful as a highly efficient antimicrobial agent, for instance when impregnated onto a carrier, or an algicide agent or a herbicide agent. | 09-24-2009 |
20100093860 | HYDROXYBUTYRATE AND POLY-HYDROXYBUTYRATE AS COMPONENTS OF ANIMAL FEED OR FEED ADDITIVES - This invention relates to the use of hydroxybutyrate and poly hydroxybutyrate as components of animal feed or feed additives, as well as to compositions, feed additives and feed containing them. The inventors surprisingly found that hydroxybutyrate and poly-hydroxybutyrate, preferably 3-hydroxybutyrate and poly-3-hydroxybutyrate, have a great potential for use in animal feed for modulation of the gut flora. More precisely, it has been found that poly-3-hydroxybutyrate or a microbial strain capable for producing poly-3-hydroxybutyrate can be used as a potential growth promoter or gut flora modulator by releasing SCFA, preferably 3-hydroxy butyric acid, in the gut micro flora. Further, the inventors found that 3-hydroxybutyrate and poly-3-hydroxybutyrate have a great potential for suppressing or inhibiting pathogenic bacteria in the gastro intestinal tract, e.g. have a antimicrobial activity against strains of | 04-15-2010 |
20100272770 | SILVER NANOPARTICLES WITH SPECIFIC SURFACE AREA AND A METHOD FOR PRODUCING THEM - Silver nanoparticles associated with 20 to 80% by weight of a biocomponent of the genus Lactobacillus, said silver nanoparticles having a ratio of the average particle size to the specific surface area (BET) of from 0.015 to 0.15 nm/m | 10-28-2010 |
20130059725 | Metallic Alloys with Microbiological Component and Catalytic Properties - This invention concerns a new material with enhanced catalytic properties, produced by mechanical alloying of microbially encapsulated metallic (or zerovalent) nanoparticles with a second metallic component. The bioencapsulation ensures a maximized contact area for molecular restructuring, since the microbial biomass can prevent agglomeration during the mechanical alloying process. The resulting product is a metallic alloy with at least 1% of the material dry weight comprising microbial biomass and with enhanced catalytic properties. | 03-07-2013 |
20130224308 | GEL COMPRISING REACTIVE OXIDANT RELEASE AGENT - Gel comprising reactive oxidant release agent The invention provides a gel composition comprising 5% to 75% w/w of an inorganic gelling agent other than silica based gelling agents, 0.5-60% w/w, preferably 0.5 to 30% w/w, of an inorganic oxidant release agent and at least 20% w/w of water, and possibly a stabilizer. It further provides a process for making same, comprising preparing a first solution of a dibasic phosphate salt in water comprising dissolved oxidant release agent, preparing a second and solution of a alkaline earth metal salt in water comprising dissolved oxidant release agent, and mixing both, first and second solutions, in a ratio of 1 to 1 to 10 to 1, followed by a concentration step. The gel composition of the invention is suitable for soil, sediment groundwater or water remediation purposes and disinfection or wound healing purposes. | 08-29-2013 |
20150086647 | PEROXYGEN RELEASE COMPOSITIONS AND METHOD FOR PRODUCING THEM - Stabilized peroxygen containing compositions are disclosed, both in thickened viscous form and in dry form. The compositions contain newly synthesized calcium sulfate crystals that function as a thickener and stabilizing agent against metal-catalyzed decomposition. The invention discloses a composition comprising 0.5 wt % to 50% wt of hydrogen peroxide. 2.0 wt % to 80.0% wt of newly synthesized calcium sulfate crystals, being of individual sheet or needle shape, and water, said composition having a viscosity of 200 cP to 20,000 cP. The invention further provides a process for making same, comprising the reaction of a water soluble calcium containing salt with sulfuric acid or a salt thereof in an aqueous hydrogen peroxide solution at a reaction temperature of up to 80 C in a mixing apparatus, followed by a concentration step in order to thicken into a stable viscous dispersion or paste containing at least 2 wt % and preferably 10 wt % to 15 wt % of CaSO | 03-26-2015 |
Patent application number | Description | Published |
20120166487 | DISTRIBUTED OBJECT STORAGE SYSTEM - The invention concerns a distributed object storage system ( | 06-28-2012 |
20120166726 | HIERARCHICAL, DISTRIBUTED OBJECT STORAGE SYSTEM - The invention concerns a distributed object storage system ( | 06-28-2012 |
20130275381 | DISTRIBUTED OBJECT STORAGE SYSTEM COMPRISING PERFORMANCE OPTIMIZATIONS - A distributed object storage system includes several performance optimizations with respect to storing very small data objects, very large data objects and CRC calculations. | 10-17-2013 |
20130286579 | DISTRIBUTED OBJECT STORAGE SYSTEM COMPRISING LOW POWER STORAGE NODES - A storage node for a distributed object storage system, comprising a control board configured to receive a parameter for setting predetermined allowable temperature ranges through a serial port, and sending a signal through said serial port for indicating one or more of said measurements of temperatures lies outside said predetermined allowable ranges. The control board is further configured to receive a parameter for controlling the switching on or off the storage elements through said serial port by sending a signal through said serial port to indicate which storage elements is switched on or off. | 10-31-2013 |
20140122441 | Distributed Object Storage System Comprising Performance Optimizations - A distributed object storage system comprises an encoding module configured to calculate for a plurality of predetermined values of the spreading requirement the cumulative size of the sub fragment files when stored on the file system with the predetermined block size; and select as a spreading requirement from said plurality of predetermined values a calculated value that is equal to one of said predetermined values for which the cumulative size is minimal. | 05-01-2014 |
20140129881 | OBJECT STORAGE SYSTEM FOR AN UNRELIABLE STORAGE MEDIUM - A method and computer device for storage and retrieval of a data object on a storage medium. The method includes steps of disassembling the data object into a predetermined number of redundant sub blocks, storing the redundant sub blocks on the storage medium, retrieving at least a predetermined multiple of a minimal spreading requirement of the redundant sub blocks from the storage medium, and assembling the data object from any combination of a particular number of the redundant sub blocks, the particular number corresponding to a predetermined multiple of a minimal spreading requirement. The computer device includes modules for performing the steps. | 05-08-2014 |
Patent application number | Description | Published |
20080270580 | METHOD AND SYSTEM FOR CONFIGURING PSEUDOWIRES USING DYNAMIC HOST CONFIGURATION PROTOCOL (DHCP) MESSAGES - A technique for configuring a pseudowire involves extending the functionality of the Dynamic Host Configuration Protocol (DHCP). In an embodiment, pseudowire configuration information is embedded into DHCP messages that are communicated between a customer edge (CE) device and a provider edge (PE) device and used to configure a pseudowire between the two devices. The pseudowire configuration information may include an indication of the pseudowire capabilities of the CE device, the types of pseudowires desired by the CE device, the types of pseudowire encapsulations supported by the CE device, the types of pseudowires that are to be configured, the pseudowire encapsulations that are to be used, and pseudowire labels. Pseudowire configuration information can be embedded into the options field of a DHCP message using a new option, using multiple new options, or by overloading an existing option. | 10-30-2008 |
20110286452 | METHOD AND APPARATUS FOR MPLS LABEL ALLOCATION FOR A BGP MAC-VPN - The invention includes a method and apparatus for distributing flooding labels within a Multiprotocol Label Switching (MPLS) infrastructure supporting Border Gateway Protocol (BGP) Media Access Control (MAC) Virtual Private Networking (VPN). | 11-24-2011 |
20120120808 | REDUCTION OF MESSAGE AND COMPUTATIONAL OVERHEAD IN NETWORKS - Various exemplary embodiments relate to a method and related network node including one or more of the following: receiving, at the node, a network update message; determining whether the network update message should be propagated to other nodes; if the network update message should be propagated to other nodes, forwarding the network update message to at least one other node; and if the network update message should not be propagated to other nodes, refraining from forwarding the network update message to any other node. Various further embodiments relate to a method and related network node including one or more of the following: determining a first time period for the network update message; setting the first time period as a delay time; waiting for the delay time; and after the delay time has elapsed, computing new routing information based on the network update message. | 05-17-2012 |
20120124238 | PRIORITIZATION OF ROUTING INFORMATION UPDATES - Various exemplary embodiments relate to a method and related network node including one or more of the following: receiving, at the node, a network state update message; updating a first portion of a first set of routing information based on the network state update message; after updating the first portion of the first set of routing information, beginning an update of a second set of routing information; and after beginning the update of the second set of routing information, updating a second portion of the first set. In various alternative embodiments, the step of updating the first portion includes one or more of the following: determining at least one other node within the network for which routing information should be used to update the second set of routing information; and updating routing information associated with the at least one other node in the first set of routing information. | 05-17-2012 |
20120219004 | GENERALIZED MULTI-HOMING FOR VIRTUAL PRIVATE LAN SERVICES - A generalized multi-homing capability is depicted and described herein. The generalized multi-homing capability supports use of a generalized multi-homed site object and associated generalized multi-homed site identifier for Virtual Private LAN Services (VPLS). For example, a generalized multi-homed site object may be generated using a multi-homed site object by associating an Ethernet endpoint object and a pseudowire endpoint object with the multi-homed site object. For example, a generalized multi-homed site object may be generated using a multi-homed site object by associating an Ethernet endpoint object with the multi-homed site object and associating one or more Ethernet-related objects with the Ethernet endpoint object. The generalized multi-homed site object is configured to support multiple types of endpoints, thereby enabling multi-homing to be supported for various types of devices in various types of networks (e.g., between devices of customer and service provider networks, between devices within a service provider network, between devices of different service provider networks, and the like) and for various types of services. | 08-30-2012 |
20140223538 | METHOD AND APPARATUS FOR PROVIDING NETWORK ACCESS TO A USER ENTITY - A method for providing network access to a plurality of user entities through an access point, said access point comprising a LAN interface and a broadband network interface, the method comprising the following steps at a gateway device: establishing a second secure communication link with said access point; receiving an IP address allocation request from one of said plurality of user entities via said second secure communication link; accessing a AAA server to verify whether a successful authentication of said one of said plurality of user entities on the basis of data related to a mobile subscription associated with said one of said plurality of user entities has already taken place; and upon successful verification, completing an IP address allocation scheme with said one of said plurality of user entities and enabling relaying of data between said one of said plurality of user entities and a PDN; wherein said gateway device is adapted to aggregate a plurality of instances of second secure communication links from different access points towards said PDN. | 08-07-2014 |
20140294004 | METHOD AND APPARATUS FOR MPLS LABEL ALLOCATION FOR A BGP MAC-VPN - The invention includes a method and apparatus for distributing flooding labels within a Multiprotocol Label Switching (MPLS) infrastructure supporting Border Gateway Protocol (BGP) Media Access Control (MAC) Virtual Private Networking (VPN). | 10-02-2014 |
20140341078 | REDUCTION OF MESSAGE AND COMPUTATIONAL OVERHEAD IN NETWORKS - Various exemplary embodiments relate to a method and related network node including one or more of the following: receiving, at the node, a network update message; determining whether the network update message should be propagated to other nodes; if the network update message should be propagated to other nodes, forwarding the network update message to at least one other node; and if the network update message should not be propagated to other nodes, refraining from forwarding the network update message to any other node. Various further embodiments relate to a method and related network node including one or more of the following: determining a first time period for the network update message; setting the first time period as a delay time; waiting for the delay time; and after the delay time has elapsed, computing new routing information based on the network update message. | 11-20-2014 |
20140355536 | SYSTEM AND METHOD PROVIDING FIXED MOBILE CONVERGENCE VIA BONDED SERVICES - Method, system and apparatus for identifying and binding together in one session multiple data bearing paths through various access technologies between a Packet Gateway (PGW) and Customer Premises Equipment (CPE) to form thereby a bonded service combining wireless and wireline bearers. | 12-04-2014 |
Patent application number | Description | Published |
20080280837 | Biologically Active Compounds with Anti-Angiogenic Properties - A method for inhibiting angiogenesis in a subject comprising administering to the subject at least one compound of General Formula (I), wherein the ring or any chiral center(s) may be of any configuration; Z is sulphur, oxygen, CH2, C(O), C(O)HN, NH, NRA or hydrogen, in the case where Z is hydrogen then R1 is not present, RA is selected from the set defined for R1 to R5, X and X′ are independently oxygen or nitrogen providing that at least one X of General Formula (I) is nitrogen, X or X′ may also combine independently with one of R1 to R5 to form an azide, R1 to R5 are independently selected from the following definition which includes but is not limited to H or an alkyl, acyl, alkenyl, alkynyl, heteroalkyl, aryl, heteroaryl, arylalkyl or heteroarylalkyl substituent of 1 to 20 atoms, which is optionally substituted, and can be branched or linear, and R6 and R7 are hydrogen, or may combine to form a carbonyl function. | 11-13-2008 |
20090023669 | Antibacterial Agents - The present invention, in one aspect, provides a method of inhibiting bacterial growth by contacting bacteria with an effective amount of at least one monosaccharide compound of formula (1) as described herein: | 01-22-2009 |
20090163373 | Method of Drug Design - The invention provides a method of identifying biologically active compounds comprising: (a) designing a first library of compounds of formula (1) to scan molecular diversity wherein each compound of the library has at least two pharmacophoric groups R1 to R5 as defined below and wherein compound of the library has same number of pharmacophoric groups; (b) assaying the first library of compounds in one or more biological assay(s); and (c) designing a second library wherein each compound of the second library contains one or more additional pharmacophoric group with respect to the first library; such that the/each component of the first and second library is a compound of formula (1). | 06-25-2009 |
20100184607 | MONOSACCHARIDE COMPOUNDS AND METHODS THEREFOR - A monosaccharide compound of formula I as shown in the specification. Processes for the preparation of the compound of formula I and methods of screening for antibacterial or antibiotic compounds involving the compound of formula I. | 07-22-2010 |
20110165700 | CLASSES OF COMPOUNDS THAT INTERACT WITH INTEGRINS - A method of inhibiting or effecting the activity of an integrin receptor comprises contacting an integrin with a pyranose of formula I, or a pharmaceutically acceptable salt thereof. | 07-07-2011 |
20110201794 | Disaccharides for drug discovery - Methods are described for the preparation of combinatorial libraries of potentially biologically active disaccharide compounds. These compounds are variously functionalized, with a view to varying lipid solubility size, function an other properties, with the particular aim of discovering novel drug or drug-like compounds, or compounds with useful properties. The invention provides intermediates, processes and synthetic strategies for the solution or solid phase synthesis of disaccharides, variously functionalized about the sugar ring, including the addition of aromaticity and charge, and the placement of pharmaceutically useful groups and isosteres. | 08-18-2011 |
20130011852 | COMPOUNDS THAT INTERACT WITH KINASES - A method of inhibiting or effecting the activity of protein kinase activity which comprises contacting a protein kinase with a compound of formula (I) being a derivative of a furanose or pyranose form of a monosaccharide, or a pharmaceutically acceptable salt thereof. | 01-10-2013 |
Patent application number | Description | Published |
20110008849 | NOVEL LACTOSE PHOSPHORYLASE ENZYMES - The present invention relates to novel lactose phosphorylase enzymes and the uses thereof. More specifically, the invention relates to lactose phosphorylase enzymes created by mutation of a cellobiose phosphorylase from | 01-13-2011 |
20120311741 | SOPHOROLIPID TRANSPORTER PROTEIN - The invention relates to a transporter protein involved in the transport of sophorolipids. More specifically, it relates to a | 12-06-2012 |
20130029384 | THERMOSTABLE SUCROSE PHOSPHORYLASE - The present invention relates to a sucrose phosphorylase from | 01-31-2013 |
20130059340 | BIOCATALYTIC PRODUCTION OF GLYCOSIDES - The present invention relates to the biocatalytic production of glycosides. In particular, the invention discloses a method to produce alkylcellobiosides, arylcellobiosides, cellobiolipids, cellotriolipids, glucosophorolipids and cellobiosesophorolipids via the usage of a cellodextrin phosphorylase (CDP) derived from | 03-07-2013 |
20130089892 | YEAST STRAINS MODIFIED IN THEIR SOPHOROLIPID PRODUCTION AND USES THEREOF - The present invention relates to yeast species which are normally capable of producing sophorolipids but which are modified in such way that they are incapable producing the latter compounds. These sophorolipid-negative strains surprisingly display equal growth characteristics and biomass formation as their wild type counterparts and are hence useful for the production of compounds such as recombinant proteins, glycolipids, polyhydroxyalkanoates and carotenoides. In addition, the present invention discloses two glucosyltransferase genes with key-functions in sophorolipid production. | 04-11-2013 |
20130302857 | TREHALOSE PHOSPHORYLASES AND THEIR USE IN THE BIOCATALYTIC PRODUCTION OF TREHALOSE-ANALOGUES AND GLYCOSYL PHOSPHATES - The present invention relates to trehalose phosphorylases which are useful for the industrial production of trehalose-analogues and glycosyl phosphates. More specifically, the invention discloses trehalose phosphorylases which are mutated in specific amino acid regions. These specific mutations result in modified substrate specificities of the enzymes. In addition, the present invention discloses a wild type trehalose phosphorylase from the marine organism | 11-14-2013 |
20140335567 | LACTONASE DERIVED FROM CANDIDA BOMBICOLA AND USES THEREOF - The present disclosure relates to an enzyme derived from | 11-13-2014 |
Patent application number | Description | Published |
20100205682 | HUMANIZED IMMUNOGLOBULIN LOCI - The present invention concerns methods and means to produce humanized antibodies from transgenic non-human animals. The invention specifically relates to novel immunoglobulin heavy and light chain constructs, recombination and transgenic vectors useful in making transgenic non-human animals expressing humanized antibodies, transgenic animals, and humanized immunoglobulin preparations. | 08-12-2010 |
20130189774 | HUMANIZED IMMUNOGLOBULIN LOCI - The present invention concerns methods and means to produce humanized antibodies from transgenic non-human animals. The invention specifically relates to novel immunoglobulin heavy and light chain constructs, recombination and transgenic vectors useful in making transgenic non-human animals expressing humanized antibodies, transgenic animals, and humanized immunoglobulin preparations. | 07-25-2013 |
20140056897 | BISPECIFIC THREE-CHAIN ANTIBODY-LIKE MOLECULES - The present invention relates to novel bispecific three-chain antigen-binding polypeptides and their preparation and use in the treatment and/or diagnosis of various diseases, and also relates to bispecific three-chain antibody-like molecules (TCAs) capable of activating immune effector cells and their use in diagnosis and/or treatment of various diseases. | 02-27-2014 |
Patent application number | Description | Published |
20120094002 | Method And Installation For Stunning Poultry And The Obtainable Bleeded Poultry - The invention relates to a method and installation for stunning poultry, such as chicken, turkey, duck and quail, comprising the steps of: i) suspending the poultry with the poultry head down; ii) positioning the suspended poultry head; and iii) stunning the poultry via the suspended and positioned poultry head, and to obtainable debleeded poultry. | 04-19-2012 |
20130309953 | Method and Installation for Killing Poultry - The invention relates to a method and installation for halal killing poultry, such as chicken, turkey, duck and quail, comprising the steps of: i) suspending the poultry with the poultry head down; ii) positioning the suspended poultry head; and iii) killing the poultry near the suspended and positioned poultry head, optionally the poultry may be prestunned. | 11-21-2013 |
20150044954 | Method and Installation for Killing Poultry - An installation and method for halal killing poultry, such as chicken, turkey, duck and quail, includes the steps of: i) suspending the poultry with the poultry head down; ii) positioning the suspended poultry head via a V-shaped positioning element; and iii) killing the poultry near the suspended and positioned poultry head, optionally the poultry may be prestunned. | 02-12-2015 |
Patent application number | Description | Published |
20100010252 | PROCESS FOR PREPARING DIARYL CARBONATES FROM DIALKYL CARBONATES - The invention provides a process for preparing diaryl carbonates from dialkyl carbonates and aromatic hydroxyl compounds using at least two reaction columns, a process section for recovering the dialkyl carbonate used in the reaction and for removing the alcohol of reaction, one or more process steps for removing the by-products obtained in the process which have a boiling point between that of the dialkyl carbonate and that of the alkyl aryl carbonate formed during the preparation of the diaryl carbonate, and a process step for further purification of the diaryl carbonate obtained from the reaction columns. | 01-14-2010 |
20110040117 | PROCESS FOR PREPARING DIALKYL CARBONATES FROM ALKYLENE CARBONATES AND ALCOHOLS - The present invention relates to a continuous process for preparing lower dialkyl carbonates as main product and alkylene glycol as by-product by catalyzed transesterification of a cyclic alkylene carbonate (e.g. ethylene carbonate or propylene carbonate) with lower alcohols, where the reaction of the alkylene carbonate is carried out with an alcohol containing dialkyl carbonate in countercurrent, characterized in that introduction of a stream containing at least 99.5% by weight of alcohol takes place below the point of introduction for the alcohol containing dialkyl carbonate in a particular spacing ratio between the abovementioned points of introduction. | 02-17-2011 |
20110144371 | PROCESS FOR PURIFYING DIALKYL CARBONATES - The present invention relates to a special process for purifying dialkyl carbonates. In particular, the present invention relates to a continuous process for purifying a dialkyl carbonate/alcohol-mixture in the preparation of lower dialkyl carbonate by catalysed transesterification of a cyclic alkylene carbonate (e.g. ethylene carbonate or propylene carbonate) with lower alcohols. To optimize the economics and energy efficiency of the process, an apparatus for intermediate heating of the internal liquid stream is used. | 06-16-2011 |
20110237819 | PROCESS FOR PREPARING DIALKYL CARBONATES - The present invention relates to a continuous process for preparing lower dialkyl carbonates as main product and alkylene glycol as by-product by transesterification of a cyclic alkylene carbonate (e.g. ethylene carbonate or propylene carbonate) with lower alkyl alcohols in the presence of a catalyst and also the required purification of the dialkyl carbonate in a subsequent process step. To optimize the economics and energy efficiency of the process, additional devices are used for intermediate heating of the liquid streams in the apparatus. | 09-29-2011 |
20120101293 | PROCESS FOR CONTINUOUSLY PREPARING DIALKYL CARBONATE - The present invention relates to a continuous process for purifying a dialkyl carbonate/alkyl alcohol mixture in the preparation of dialkyl carbonate by catalysed transesterification of a cyclic alkylene carbonate (e.g. ethylene carbonate or propylene carbonate) with alkyl alcohols. For the increase in the product quality of the dialkyl carbonate, the selection of the operating parameters of the dialkyl carbonate purification column are crucial, in order to reduce the formation of unwanted by-products such as alkoxy alcohols and aliphatic carbonate ethers. | 04-26-2012 |
20120130110 | PROCESS FOR CONTINUOUSLY PREPARING DIALKYL CARBONATE - The present invention relates to a process comprising purifying dialkyl carbonates of the formula (II) in one or more columns in the presence of an alkylene oxide of the formula (V) and of an alkyl alcohol of the formula (IV) | 05-24-2012 |