Patent application number | Description | Published |
20110190746 | CONTACT LASER ABLATION OF TISSUE - Apparatus and methods are described for laser ablation of tissue. The apparatus and methods utilize a laser source coupled to a fiberoptic laser delivery device and a laser driver and control system with features for protection of the laser delivery device, the patient, the operator and other components of the laser treatment system. Advantageously, the laser source may utilize laser diodes operating at approximately 975 nm, 1470 nm, 1535 nm or 1870 nm wavelengths with a laser power output of at least 60 watts, preferably greater than 80 watts and most preferably 120-150 watts or higher. The invention, which has broad medical and industrial applications, is described in relation to a method for treatment of benign prostatic hyperplasia (BPH) by contact laser ablation of the prostate (C-LAP). | 08-04-2011 |
20120232534 | MULTI-WAVELENGTH LASER AND METHOD FOR CONTACT ABLATION OF TISSUE - A multi-wavelength laser apparatus and methods for laser ablation of tissue are described. The apparatus and methods utilize a laser source emitting at two or more wavelengths coupled to a fiberoptic laser delivery device and a laser driver and control system with features for protection of the laser delivery device, the patient, the operator and other components of the laser treatment system. A fiber tip protection system limits damage to the fiberoptic laser delivery device, thereby allowing the multi-wavelength laser to be operated in a tissue contact mode. The invention, which has broad medical and industrial applications, is described in relation to a method for treatment of benign prostatic hyperplasia (BPH) by contact laser ablation of the prostate (C-LAP) using a technique of touch and pullback laser ablation of the prostate (TapLAP). | 09-13-2012 |
20150141969 | MULTI-WAVELENGTH LASER AND METHOD FOR CONTACT ABLATION OF TISSUE - A multi-wavelength laser apparatus and methods for laser ablation of tissue are described. The apparatus and methods utilize a laser source emitting at two or more wavelengths coupled to a fiberoptic laser delivery device and a laser driver and control system with features for protection of the laser delivery device, the patient, the operator and other components of the laser treatment system. A fiber tip protection system limits damage to the fiberoptic laser delivery device, thereby allowing the multi-wavelength laser to be operated in a tissue contact mode. The invention, which has broad medical and industrial applications, is described in relation to a method for treatment of benign prostatic hyperplasia (BPH) by contact laser ablation of the prostate (C-LAP) using a technique of touch and pullback laser ablation of the prostate (TapLAP). | 05-21-2015 |
Patent application number | Description | Published |
20110308897 | ELECTRONIC STROKE SENSOR FOR AIR DISC BRAKE - A vehicle brake monitor assembly for an air disk brake includes a brake actuator having a pushrod projecting from inside a chamber of said brake actuator. The pushrod releasably actuates a lever arm of a caliper thereby moving the disk brake into a braking position when the pushrod is in an extended position and releasing the disk brake from the braking position when the pushrod is in a retracted position. The pushrod includes a pushrod shaft and a contact member biased in a telescoping relationship relative to the pushrod shaft and the lever arm of the caliper abuts the contact member counteracting the bias of the contact member. A sensor is integrated with the assembly proximate the contact member and detects movement of the pushrod relative to the lever arm and to the pushrod shaft. | 12-22-2011 |
20130072351 | BRAKE MONITORING SYSTEM AND METHOD - A brake monitoring system and method for a vehicle having multiple axles and a plurality of brake actuators and an engine control module, each brake actuator being associated with one of the axle. The system include sensors for measuring, in real-time, brake pressure and brake lining wear, and generating first and second signals. The first and second signals are received and stored in a chassis communications module. The chassis communications module detects fault condition of the brakes as a function of the first and/or second signals and for recording the fault condition, the fault condition being one of a brake monitor warning and a brake lining warning and provides an indication of status via warning lights. | 03-21-2013 |
20140046537 | ELECTRONIC STROKE SENSOR FOR AIR DISC BRAKE - A vehicle brake monitor assembly for an air disk brake includes a brake actuator having a pushrod projecting from inside a chamber of said brake actuator. The pushrod releasably actuates a lever arm of a caliper thereby moving the disk brake into a braking position when the pushrod is in an extended position and releasing the disk brake from the braking position when the pushrod is in a retracted position. The pushrod includes a pushrod shaft and a contact member biased in a telescoping relationship relative to the pushrod shaft and the lever arm of the caliper abuts the contact member counteracting the bias of the contact member. A sensor is integrated with the assembly proximate the contact member and detects movement of the pushrod relative to the lever arm and to the pushrod shaft. | 02-13-2014 |
20140277928 | ELECTRONIC STROKE SENSOR FOR AIR DISC BRAKE - A vehicle brake monitor assembly for an air disk brake includes a brake actuator having a pushrod projecting from inside a chamber of said brake actuator. The pushrod releasably actuates a lever arm of a caliper thereby moving the disk brake into a braking position when the pushrod is in an extended position and releasing the disk brake from the braking position when the pushrod is in a retracted position. The pushrod includes a pushrod shaft and a contact member biased in a telescoping relationship relative to the pushrod shaft and the lever arm of the caliper abuts the contact member counteracting the bias of the contact member. A sensor is integrated with the assembly proximate the contact member and detects movement of the pushrod relative to the lever arm and to the pushrod shaft. | 09-18-2014 |
20160107631 | BRAKE MONITORING ASSEMBLY FOR A RAIL SYSTEM - A brake monitoring assembly and method for monitoring a brake system of a train includes a plurality of train bogeys supporting each train car, each bogey having a wheel axle supporting wheels engaging a train track. Each wheel axle includes a tread brake and a disc brake. A tread brake actuator includes an extendable tread brake pushrod for actuating the tread brake. A disc brake actuator includes an extendable disc brake pushrod for actuating the disc brake. A pneumatic system provides pneumatic pressure for actuating the brakes and includes a sensor for monitoring pressure. Each brake actuator includes a sensor for detecting length of extension of a pushrod. A controller identifies a condition of the actuators when the pressure detected by the sensor is inconsistent with a length of extension of any of the pushrods and signals an indicator for indicating a condition of the actuators. | 04-21-2016 |
Patent application number | Description | Published |
20090042246 | Methods For The Production And Secretion Of Modified Peptides - The invention relates to the production of heterologous polypeptides in a recombinant host cell. More specifically, it relates to the production and secretion of peptides, such as biologically active peptides, that are modified by one or more lantibiotic-synthesizing enzymes. Provided is a nucleic acid construct encoding a polypeptide comprising 1) a non-lantibiotic export signal that is recognized by a non-lantibiotic export system; 2) a lantibiotic leader peptide that is recognized by at least a lantibiotic dehydratase such as LanB and, C-terminally of said export signal and said leader peptide, 3) a peptide of interest containing one or more serine or threonine residue(s) which can be posttranslationally dehydrated by said dehydratase. Also provided is a method for producing a polypeptide in a host cell, comprising providing a host cell with a nucleic acid construct according to the invention and allowing expression and secretion of the encoded polypeptide by said host cell, wherein said host cell comprises at least a dehydratase capable of modifying said encoded polypeptide and a non-lantibiotic export system capable of secreting said modified polypeptide. | 02-12-2009 |
20100055146 | CYCLIC ANGIOTENSIN ANALOGS - The invention relates to analogs of angiotensins, in particular to cyclised analogs having Ang(1-8) agonistic or antagonistic activity and to cyclised Ang(1-7) analogs with agonistic or antagonistic activity and displaying improved proteolytic resistance compared to their linear counterparts. Provided is a cyclic angiotensin peptide analog comprising a thioether-bridge linkage between the amino acids corresponding to positions Tyr | 03-04-2010 |
20120165230 | BIOLOGICALLY PRODUCED CYCLIC AFFINITY TAGS - Described are novel ways of introducing an affinity tag into a protein of interest. Provided is an enzymatic method for providing a proteinaceous substance comprising a polypeptide of interest and a cyclic affinity tag, comprising: (a) providing at least one precursor proteinaceous substance, the precursor comprising the protein of interest and at least one motif of the general formula X1-Tag-X2, wherein X1 and X2 represent amino acids whose side chains can be linked enzymatically by a covalent bond; Tag is a short amino acid sequence capable of binding to a binding partner of the tag when cyclized; (b) contacting the precursor with at least one enzyme capable of forming a covalent bond between X1 and X2, thereby introducing an intramolecular ring structure comprising the Tag sequence; and (c) isolating the resulting cyclized proteinaceous substance. Also provided are proteinaceous substances obtainable thereby and the use thereof, for instance, for preparing a peptide library. | 06-28-2012 |
20140094400 | Novel Angiotensin Type 2 (AT2) Receptor Agonists and Uses Thereof - The invention relates to novel pharmaceutically-useful peptides, in particular cyclic peptides that are agonists of the AngII type 2 receptor (AT2 receptor). The invention further relates to the use of such peptides as medicaments, to pharmaceutical compositions containing them, and to their production. | 04-03-2014 |
Patent application number | Description | Published |
20090162926 | PHOTON REDUCING AGENTS FOR FLUORESCENCE ASSAYS - The present invention provides a method for reducing undesirable light emission from a sample using at least one photon producing agent and at least one photon reducing agent (e.g. dye-based photon reducing agents). The present invention further provides a method for reducing undesirable light emission from a sample (e.g. a biochemical or cellular sample) with at least one photon producing agent and at least one collisional quencher. The present invention also provides a method for reducing undesirable light emission from a sample (e.g., a biochemical or cellular sample) with at least one photon producing agent and at least one quencher, such as an electronic quencher. The present invention also provides a system and method of screening test chemicals in fluorescent assays using photon reducing agents. The present invention also provides compositions, pharmaceutical compositions, and kits for practicing these methods. | 06-25-2009 |
20110076711 | PHOTON REDUCING AGENTS FOR FLUORESCENCE ASSAYS - The present invention provides a method for reducing undesirable light emission from a sample using at least one photon producing agent and at least one photon reducing agent (e.g. dye-based photon reducing agents). The present invention further provides a method for reducing undesirable light emission from a sample (e.g., a biochemical or cellular sample) with at least one photon producing agent and at least one collisional quencher. The present invention also provides a method for reducing undesirable light emission from a sample (e.g., a biochemical or cellular sample) with at least one photon producing agent and at least one quencher, such as an electronic quencher. The present invention also provides a system and method of screening test chemicals in fluorescent assays using photon reducing agents. The present invention also provides compositions, pharmaceutical compositions, and kits for practicing these methods. | 03-31-2011 |
20130004960 | PHOTON REDUCING AGENTS FOR FLUORESCENCE ASSAYS - The present invention provides a method for reducing undesirable light emission from a sample using at least one photon producing agent and at least one photon reducing agent (e.g. dye-based photon reducing agents). The present invention further provides a method for reducing undesirable light emission from a sample (e.g., a biochemical or cellular sample) with at least one photon producing agent and at least one collisional quencher. The present invention also provides a method for reducing undesirable light emission from a sample (e.g., a biochemical or cellular sample) with at least one photon producing agent and at least one quencher, such as an electronic quencher. The present invention also provides a system and method of screening test chemicals in fluorescent assays using photon reducing agents. The present invention also provides compositions, pharmaceutical compositions, and kits for practicing these methods. | 01-03-2013 |