Mara
Mara Amoros-Alonso, Heidelberg DE
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20100323384 | LABELING OF HUMAN EPIDERMAL STEM CELLS - The present invention provides skin equivalents comprising human epidermal stem cells which are specifically labeled. The labeling is carried out with a marker capable of labeling slowly proliferating cells, e.g. iododeoxyuridine or PKH26. Particularly, the invention provides skin equivalents comprising labeled epidermal stem cells. The invention also provides corresponding uses and methods of using such cultures, e.g. in the fields of research and medical treatment of skin diseases. | 12-23-2010 |
Mara Bagnasco, Milan IT
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20110034963 | SUPPORT ORTHOPAEDIC DEVICE FOR A KNEE JOINT - Support orthopaedic device ( | 02-10-2011 |
Mara Bagnasco, Milano IT
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20100222778 | ORTHOPAEDIC DEVICE TO BE ASSOCIATED WITH THE OUTSIDE OF A BONE - The present invention regards an orthopaedic device ( | 09-02-2010 |
20110112533 | Clamp for External Orthopaedic Fixing Device | 05-12-2011 |
20110172664 | ORTHOPAEDIC DEVICE FOR CORRECTING DEFORMITIES OF LONG BONES - Orthopaedic device ( | 07-14-2011 |
20120172875 | INTRAMEDULLARY NAIL WITH SHAPE MEMORY ELEMENTS FOR ELONGATED BONES - An intramedullary nail for a fractured elongated bone, comprising a cannulated rod having proximal and distal ends; an outside tubular sleeve for coaxially hosting and guiding the rod; and at least a pair of shape memory elements hosted in corresponding seats at the distal end of the rod. Each shape memory element can be retractably housed in its seat in a first configuration, allowing insertion of the nail into the bone, and can project from a sleeve opening in another configuration. Pairs of transversal holes are provided in proximal portions of the rod and the sleeve. The distal pair of shape memory elements lie on an offset plane to the plane of the proximal holes and are kept in their corresponding seats by a distal cover fixed to the rod. This improves the stability of the nail in the medullary canal. | 07-05-2012 |
20120172876 | INTRAMEDULLARY NAIL WITH SHAPE MEMORY ELEMENTS - An intramedullary nail for a fractured elongated bone, comprising a cannulated rod having proximal and distal ends; an outside tubular sleeve for coaxially hosting and guiding the rod; and shape memory elements hosted in corresponding seats of the rod. Each shape memory element can be retractably housed in its respective seat in a first configuration, allowing insertion of the nail into the bone, and can project from a sleeve opening in another configuration. Proximal and distal pairs of the elements are provided at the proximal and distal rod ends. The proximal element pair lie on a same plane and are kept in their seats by a proximal cover. The distal element pair lie on an offset plane to the plane of the proximal element pair and are kept in their seats by a distal cover. This removes the need for bone screws to stabilize the nail inside the medullary canal. | 07-05-2012 |
20150150600 | ORTHOPAEDIC DEVICE FOR CORRECTING DEFORMITIES OF LONG BONES - Orthopaedic device ( | 06-04-2015 |
Mara Boenitz-Dulat, Tutzing DE
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20090148874 | MUTANTS OF PYRROLOQUINOLINE QUINONE DEPENDENT SOLUBLE GLUCOSE DEHYDROGENASE - A mutant of PQQ-dependent soluble glucose dehydrogenase (s-GDH; EC 1.1.5.2) is provided with improved specificity for glucose as compared to maltose, having a substitution of threonine at position 348 by either glycine, alamine or serine, wherein said mutant additionally comprises, at least one mutation for improving the stability of the mutant and one or more mutation(s) for improving the affinity of the mutant to glucose, and/or one or more mutation(s) for further improving the specificity of the mutant for glucose as compared to maltose, and wherein position 348 correspond to the amino acid positions known from the | 06-11-2009 |
20090305316 | Thermostable mutants of pyrroloquinoline quinone dependent glucose dehydrogenase - The present invention relates to a mutant protein of PQQ-dependent s-GDH characterized in that in at least one of the positions 122 and 124 the amino acid lysine is present, wherein these positions correspond to the amino acid positions known from the | 12-10-2009 |
Mara Brancaccio, Torino IT
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20120010386 | RECOMBINANT MELUSIN FUSION PROTEIN AS PHARMACOLOGICAL AGENT IN THE TREATMENT OF HEART PATHOLOGIES AND COMPOSITIONS THEREOF - A recombinant melusin fusion protein having an improved stability and a capability to reach intracellular compartments as compared to recombinant melusin in vivo, wherein said protein comprises i) a human melusin protein having the amino acid sequence as defined in SEQ ID No.:1, or a homologue thereof having at least 60%, preferably at least 80%, more preferably at least 90% sequence identity to SEQ ID No.:1 and having the function of native melusin protein or a human melusin portion derived from SEQ ID No.:1 or homologue thereof having at least 60%, preferably at least 80%, more preferably at least 90% sequence identity of the melusin portion derived from SEQ ID No.:1 and having the function of native melusin protein and ii) a cell penetrating polypeptide. | 01-12-2012 |
Mara Brunati, Olgiate Comasco IT
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20140356345 | New Proteases Able to Hydrolyze Gluten Peptides and Proteins at Acidic PH, from the Actinomycete Actinoallomurus - The invention relates to a new family of proteolytic enzymes having the ability to hydrolize at a p H between 3 and 8 gluten olygopeptides which are resistant to cleavage by gastric and pancreatic enzymes and whose presence in the intestinal lumen results in toxic effects. The enzymes have been identified as endopeptidases of the S8/S53 family and are produced by an | 12-04-2014 |
Mara Cassin, Bresso IT
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20090036441 | Indole Derivatives With Antitumor Activity - 3H-Benzo[e]indol-4,5-dione derivatives with antitumor activity, the processes for the preparation thereof and pharmaceutical compositions containing them. | 02-05-2009 |
Mara Cassin, Milano IT
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20080255099 | Use of Diketodithiopiperazine Antibiotics for the Preparation of Antiangiogenic Pharmaceutical Compositions - The invention relates to the use of diketodithiopiperazine antibiotics, in particular chaetocin and gliotoxin, for the preparation of pharmaceutical compositions for antitumor therapy. | 10-16-2008 |
20080261980 | Use of Thiazolidinone Derivatives as Antiangiogenic Agents - The invention relates to the use of compounds of general formula (I), in which R | 10-23-2008 |
Mara Concolato, Emarese IT
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20110007858 | METHOD OF DETECTING A FRAME SYNCHRONIZATION PATTERN OR UNIQUE WORD IN A RECEIVED DIGITAL SIGNAL - The recognition of a frame synchronization pattern or unique word of a received signal may be enhanced using a data-aided estimator of the signal-to-noise ratio (SNR) together with a correlation detector of the unique word to be received. Detecting a frame synchronization pattern or a unique word in a received signal, the SNR is estimated on the received signal with a data-aided SNR estimator using the unique word to be received. If the estimated SNR exceeds a certain threshold, an eventual recognition of the unique word established by a correlation correlator of the receiver is considered reliable. Comparing the SNR with the threshold may be carried out either before or after the correlator has processed the unique word. | 01-13-2011 |
Mara Destro, Bologna IT
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20090247406 | Encapsulated Luminescent Pigments - The instant invention relates to encapsulated luminescent pigments, which are encapsulated by a polymeric shell. Further aspects of the invention are polymeric compositions containing these encapsulated luminescent pigments and their use in electronic devices and agricultural films. | 10-01-2009 |
20090289236 | STABILIZATION OF PHOTOCHROMIC SYSTEMS - Photochromic compositions are disclosed comprising a polymeric material, a photochromic dye, a hydroxyphenyl triazine UV absorber and, optionally, a further light stabilizer selected from the sterically hindered amines. These systems provide a reversible photochromic effect and show improved light stabilization and color fastness. | 11-26-2009 |
20090302284 | Reversibly Thermochromic Compositions - The present invention pertains to a reversibly thermochromic system comprising a substituted or an unsubstituted 6,11-dihydroxy-naphthacene-5,12-dione and a base and to a reversibly thermochromic composition comprising the reversibly thermochromic system and a carrier material and to novel substituted 6,11-dihydroxy-naphthacene-5,12-diones. | 12-10-2009 |
20100285190 | PROCESS FOR REMOVING ETHENE FROM BIOLOGICAL USING METAL EXCHANGED TITANIUM ZEOLITES - The instant invention relates to a process for removing ethene from biological sources using metal ion exchanged titanium zeolites. Further aspects of the invention are polymer compositions containing these zeolites, their use as efficient ethene removing additives and the modified titanium zeolites self. | 11-11-2010 |
20110015297 | NANO STRUCTURED UV ABSORBERS - The present invention relates to an UV absorbing polymer composition comprising effective amounts of (a1) a nanoparticulate oxide selected from oxides of the groups 4 and 12 of the periodic table, wherein the oxide is doped with In, Ga and/or Al, and (b1) a UV stabilizing/absorbing substance comprising a sterically hindered amine and/or a polymeric hydroxyphenyl-triazine; or (a2) a nanoparticulate oxide selected from oxides of the groups 4 and 12, and (b2) a UV light stabilizing substance comprising a N-oxygen-substituted sterically hindered amine. Furthermore, the present invention relates to a polymer comprising said composition and the use of said composition as a UV absorber in polymers, particularly in agricultural films or packaging films. Finally, the present invention relates to a process for producing doped nanoparticulate metal oxides. | 01-20-2011 |
20130211011 | AUTOMOTIVE INTERIOR ELEMENT - Automotive interior element comprising a polypropylene composition comprising (percent by weight): A) from 60% to 90% of a propylene homopolymer having: i) a polydispersity Index (P.I.) value of from 3.5 to 10.0; ii) a fraction insoluble in xylene at 25° C., higher than 90%; and iii) a MFR L (Melt Flow Rate according to ISO 1133, condition L, i.e. 230° C. and 2.16 kg load) from 50 to 200 g/10 min; B) from 10% to 40%; of a copolymer of propylene with from 30% to 60% of ethylene derived units; the composition having an intrinsic viscosity of the fraction soluble in xylene at 25° C. comprised between 2.5 and 4.0 dl/g; a MFR L (Melt Flow Rate according to ISO 1133, condition L, i.e. 230° C. and 2.16 kg load) from 15 to 100 g/10 min and all the three values of carbon emission measured according to VDA 227 (C-emission) are lower than 30.0 μgC/g; wherein the values of carbon emission are measured in the ex reactor propylene composition. | 08-15-2013 |
20130316213 | POLYOLEFIN COMPOSITION - A polyolefin composition comprising: | 11-28-2013 |
Mara Destro, Ferrara IT
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20140171592 | Case for valve-regulated lead-acid batteries - A case for valve-regulated lead-acid battery comprising an olefin polymer composition comprising: | 06-19-2014 |
20150045514 | PROPYLENE POLYMER COMPOSITIONS - Propylene polymer compositions comprising: | 02-12-2015 |
20150051351 | PROPYLENE POLYMER COMPOSITIONS - Propylene polymer compositions comprising: | 02-19-2015 |
20150307700 | POLYOLEFIN COMPOSITION - A polyolefin composition comprising: | 10-29-2015 |
Mara Ferrandi, Milan IT
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20090209506 | AMINO DERIVATIVES OF BETA-HOMOANDROSTANES AND BETA-HETEROANDROSTANES - New aminoalkoxyimino derivatives at position 3 of substituted B-homoandrostanes and B-heteroandrostanes, processes for their preparation, and to pharmaceutical compositions containing them for the treatment of cardiovascular disorders, such as heart failure and hypertension. In particular compounds having the general formula (I) are described, where the radicals have the meanings described in detail in the application. | 08-20-2009 |
Mara Ferrandi, Milano IT
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20120028945 | 5-Beta, 14-Beta-Androstane Derivatives Useful For The Treatment Of Proteinuria, Glomerulosclerosis And Renal Failure - Compound of formula (I), wherein the symbol have the meaning reported in the text; for preparing a medicament for the prevention and/or treatment of proteinuria, glomerulosclerosis or renal failure. | 02-02-2012 |
20130310423 | DITERPENOID DERIVATIVES ENDOWED OF BIOLOGICAL PROPERTIES - The present invention relates to new diterpenoid derivatives of formula (I), processes for their preparation, and to pharmaceutical compositions containing them for the treatment of cardiovascular disorders, urinary incontinence, asthma, or Alzheimer's disease and/or to prevent obstructive vascular lesions consequently to arteriotomy and/or angioplasty, and to prevent organ damage in hypertensive patients. | 11-21-2013 |
Mara Fornaro, Basel CH
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20100234290 | Stabilized Insulin-like Growth Factor Polypeptides - The invention relates to stabilized polypeptides having an IGF-1 or IGF-2 sequence and an E-peptide sequence, where the natural physiological cleavage of the E-peptide from the IGF is prevented. | 09-16-2010 |
20110218145 | ANTIBODIES TO MODIFIED HUMAN IGF-1/E PEPTIDES - High-specificity antibodies can distinguish between modified (e.g, hIGF-1/Ea 3mut) and endogenous wild-type human IGF-1 proteins. These antibodies have little or no cross-reactivity with hIGF-1 or hIGF-2. They also have little or no cross-reactivity with rodent IGF-1 or IGF-2. The antibodies can be used in pharmacokinetic (PK)/pharamcodynamic (PD) assessments of IGF-1/E peptides that have been administered to humans or animals. A sandwich ELISA assay, using the antibody of the invention as a capture antibody, can quantify the mutant IGF-1/E proteins in samples. | 09-08-2011 |
20140235538 | Stabilized Insulin-like Growth Factor Polypeptides - The invention relates to stabilized polypeptides having an IGF-1 or IGF-2 sequence and an E-peptide sequence, where the natural physiological cleavage of the E-peptide from the IGF is prevented. | 08-21-2014 |
20140243265 | ANTIBODIES TO MODIFIED HUMAN IGF-1/E PEPTIDES - High-specificity antibodies can distinguish between modified (e.g, hIGF-1/Ea 3mut) and endogenous wild-type human IGF-1 proteins. These antibodies have little or no cross-reactivity with hIGF-1 or hIGF-2. They also have little or no cross-reactivity with rodent IGF-1 or IGF-2. The antibodies can be used in pharmacokinetic (PK)/pharamcodynamic (PD) assessments of IGF-1/E peptides that have been administered to humans or animals. A sandwich ELISA assay, using the antibody of the invention as a capture antibody, can quantify the mutant IGF-1/E proteins in samples. | 08-28-2014 |
20150322131 | PRODUCTION OF THERAPEUTIC PROTEINS IN GENETICALLY MODIFIED MAMMALIAN CELLS - The invention relates to methods for the production of therapeutic proteins in mammalian cells. In one embodiment, the method comprises producing a therapeutic protein such as IGF-1 in a mammalian cell endogenously expressing a cognate receptor of said recombinant therapeutic protein and wherein binding of said therapeutic protein to said cognate receptor results in a low titer of the therapeutic protein, the method comprising with a mammalian cell being deficient in the expression of the cognate receptor of said therapeutic protein and being transformed with an expression vector comprising a nucleic acid molecule encoding the therapeutic protein: a. Cultivating said cell under conditions allowing the expression of the therapeutic protein; and b. Harvesting the therapeutic protein from the mammalian cell cultivated in step a, wherein said mammalian cell produces at least 1.5 fold more therapeutic protein than a cell in which the expression of the cognate receptor has not been so modified. | 11-12-2015 |
20150329614 | STABILIZED INSULIN-LIKE GROWTH FACTOR POLYPEPTIDES - This invention is in the field of IGF-1 modifications. In particular, it relates to modified IGF-polypeptides and modified IGF-1 precursor polypeptides wherein the cleavage of E-peptide is prevented. The invention also relates to the use of such polypeptides for treating muscle diseases and disorders. | 11-19-2015 |
Mara Gellini, Roma IT
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20120282257 | SINGLE-CHAIN VARIABLE FRAGMENT (SCFV) ABLE TO RECOGNIZE AND BIND CD99 HUMAN PROTEIN - The present invention relates to a single-chain variable fragment (scFv) able to recognize an epitope of the extracellular domain of CD99 human protein. | 11-08-2012 |
Mara Gerloni, San Diego, CA US
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20100040648 | PLASMIDS WITH IMMUNOLOGICAL ACTION - Recombinant plasmids usable for the transfection of eukaryotic and prokaryotic cells are described; such plasmids have a length comprised between 7 and 12 kbases and comprise a sequence encoding the heavy chain of an immunoglobulin; in particular, they may be used: | 02-18-2010 |
20120076807 | PLASMIDS WITH IMMUNOLOGICAL ACTION - Recombinant plasmids usable for the transfection of eukaryotic and prokaryotic cells are described; such plasmids have a length comprised between 7 and 12 kbases and comprise a sequence encoding the heavy chain of an immunoglobulin; in particular, they may be used: | 03-29-2012 |
Mara Leimanis, Pointe Claire CA
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20110204257 | HAEMOZOIN DETECTION - A system for detecting haemozoin in a sample, said system including a light source for exciting the sample with an optical signal to generate a non-linear optical response, and a detector for detecting the generated non-linear optical response from the excited sample. A method for detecting haemozoin in a sample, the method including exciting the sample with an optical signal to generate a non-linear optical response from the sample, and detecting the emitted non-linear optical signal from the excited sample. | 08-25-2011 |
Mara Nemas, Gedera IL
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20100298428 | Continuous Administration of Dopa Decarboxylase Inhibitors and Compositions for Same - Disclosed herein are compositions that include for example the arginine salt of carbidopa, and methods for treating neurological or movement diseases or disorders such as restless leg syndrome, Parkinson's disease, secondary parkinsonism, Huntington's disease, Parkinson's like syndrome, PSP, MSA, ALS, Shy-Drager syndrome and conditions resulting from brain injury including carbon monoxide or manganese intoxication, using substantially continuous administration of carbidopa or salt thereof together with administration of levodopa. | 11-25-2010 |
20100298429 | Continuous Administration of Dopa Decarboxylase Inhibitors and Compositions for Same - Disclosed herein are compositions that include for example the arginine salt of carbidopa, and methods for treating neurological or movement diseases or disorders such as restless leg syndrome, Parkinson's disease, secondary parkinsonism, Huntington's disease, Parkinson's like syndrome, PSP, MSA, ALS, Shy-Drager syndrome and conditions resulting from brain injury including carbon monoxide or manganese intoxication, using substantially continuous administration of carbidopa or salt thereof together with administration of levodopa. | 11-25-2010 |
20110269833 | Continuous Administration of Dopa Decarboxylase Inhibitors and Compositions for Same - Disclosed herein are compositions that include for example the arginine salt of carbidopa, and methods for treating neurological or movement diseases or disorders such as restless leg syndrome, Parkinson's disease, secondary parkinsonism, Huntington's disease, Parkinson's like syndrome, PSP, MSA, ALS, Shy-Drager syndrome and conditions resulting from brain injury including carbon monoxide or manganese intoxication, using substantially continuous administration of carbidopa or salt thereof together with administration of levodopa. | 11-03-2011 |
20130253056 | Continuous Administration of Levodopa and/or Dopa Decarboxylase Inhibitors and Compositions for Same - Disclosed herein are for example, liquid aqueous compositions that include for example an ester or salt of levodopa, or an ester or salt of carbidopa, and methods for treating neurological or movement diseases or disorders such as restless leg syndrome, Parkinson's disease, secondary parkinsonism, Huntington's disease, Parkinson's like syndrome, PSP, MSA, ALS, Shy-Drager syndrome, dystonia, and conditions resulting from brain injury including carbon monoxide or manganese intoxication, using substantially continuous administration of levodopa and/or carbidopa or ester and/or salt thereof. | 09-26-2013 |
20130338143 | Compositions for Transdermal Delivery of Active Agents - Disclosed herein are compositions that are useful in effecting the transdermal delivery of therapeutic agents. More particularly, the disclosed transdermal compositions may include a fatty alcohol (for example, octanol), a terpene (for example, limonene), and an active agent comprising an amine moiety. | 12-19-2013 |
20140051755 | Continuous Administration of L-Dopa, Dopa Decarboxylase Inhibitors, Catechol-O-Methyl Transferase Inhibitors and Compositions for Same - Provided herein, in part, is a method of treating a neurological or movement disorder in a patient in need thereof, comprising subcutaneously administering to said patient a pharmaceutically acceptable composition comprising levodopa and optionally carbidopa and optionally entacapone or tolcapone, or pharmaceutically acceptable salts thereof, wherein said composition is administered substantially continuously, and compositions that can be used in the disclosed methods. | 02-20-2014 |
20140249228 | CONTINUOUS ADMINISTRATION OF L-DOPA, DOPA DECARBOXYLASE INHIBITORS, CATECHOL-O-METHYL TRANSFERASE INHIBITORS AND COMPOSITIONS FOR SAME - Provided herein, in part, is a method of treating a neurological or movement disorder in a patient in need thereof, comprising subcutaneously administering to said patient a pharmaceutically acceptable composition comprising levodopa and optionally carbidopa and optionally entacapone or tolcapone, or pharmaceutically acceptable salts thereof, wherein said composition is administered substantially continuously, and compositions that can be used in the disclosed methods. | 09-04-2014 |
20140249229 | CONTINUOUS ADMINISTRATION OF L-DOPA, DOPA DECARBOXYLASE INHIBITORS, CATECHOL-O-METHYL TRANSFERASE INHIBITORS AND COMPOSITIONS FOR SAME - Provided herein, in part, is a method of treating a neurological or movement disorder in a patient in need thereof, comprising subcutaneously administering to said patient a pharmaceutically acceptable composition comprising levodopa and optionally carbidopa and optionally entacapone or tolcapone, or pharmaceutically acceptable salts thereof, wherein said composition is administered substantially continuously, and compositions that can be used in the disclosed methods. | 09-04-2014 |
20140249230 | Continuous Administration of Dopa Decarboxylase Inhibitors and Compositions for Same - Disclosed herein are compositions that include for example the arginine salt of carbidopa, and methods for treating neurological or movement diseases or disorders such as restless leg syndrome, Parkinson's disease, secondary parkinsonism, Huntington's disease, Parkinson's like syndrome, PSP, MSA, ALS, Shy-Drager syndrome and conditions resulting from brain injury including carbon monoxide or manganese intoxication, using substantially continuous administration of carbidopa or salt thereof together with administration of levodopa. | 09-04-2014 |
20140249231 | Continuous Administration of Dopa Decarboxylase Inhibitors and Compositions for Same - Disclosed herein are compositions that include for example the arginine salt of carbidopa, and methods for treating neurological or movement diseases or disorders such as restless leg syndrome, Parkinson's disease, secondary parkinsonism, Huntington's disease, Parkinson's like syndrome, PSP, MSA, ALS, Shy-Drager syndrome and conditions resulting from brain injury including carbon monoxide or manganese intoxication, using substantially continuous administration of carbidopa or salt thereof together with administration of levodopa. | 09-04-2014 |
20150182523 | COMPOSITIONS COMPRISING APOMORPHINE AND ORGANIC ACIDS AND USES THEREOF - The present invention provides stable liquid or semi-solid pharmaceutical compositions of apomorphine, more particularly composition comprising apomorphine and an organic acid, which are useful in treatment of neurological or movement diseases or disorders, e.g., Parkinson's disease, or conditions associated therewith. | 07-02-2015 |
20160067339 | COMPOSITIONS COMPRISING APOMORPHINE AND ORGANIC ACIDS AND USES THEREOF - The present invention provides stable liquid or semi-solid pharmaceutical compositions of apomorphine, more particularly compositions comprising apomorphine and an organic acid, which are useful in treatment of neurological or movement diseases or disorders, e.g., Parkinson's disease, or conditions associated therewith. | 03-10-2016 |
Mara Pittarello, Abano Terme IT
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20080275006 | Process for the Preparation and Isolation of Phosphatides - Process for the preparation of phosphatidylserine of formula | 11-06-2008 |
Mara Sherman, San Diego, CA US
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20160089385 | VITAMIN D RECEPTOR AGONISTS TO TREAT DISEASES INVOLVING CXCL12 ACTIVITY - Provided herein are methods of treating and preventing pancreatitis, such as pancreatitis induced by glucagon-like peptide (GLP) agonists (such as GLP-1 agonists, for example Byetta®), by administration of a vitamin D receptor agonist (such as vitamin D, vitamin D analogs, vitamin D precursors, and vitamin D receptor agonists precursors). In some examples the subject has diabetes, such as type 2 diabetes. | 03-31-2016 |
Mara Szyrach, Tubingen DE
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20100016847 | CRYOSURGICAL INSTRUMENT FOR SEPARATING A TISSUE SAMPLE FROM SURROUNDING TISSUE OF A BIOLOGICAL TISSUE THAT IS TO BE TREATED - The invention relates to a cryosurgical instrument and a method for separating a tissue sample from surrounding tissue of a biological tissue that is to be treated. The cryosurgical instrument comprises a probe for guiding a probe head on to a biological tissue to be treated, and gas conduits for delivering coolant gas, wherein the probe head is designed in such a way that, in order to collect a tissue sample, a limited region of the tissue can be cooled by means of the gas delivered and can be separated from the surrounding tissue in a state in which it is frozen on the probe head. The instrument is intended to permit reliable removal of a tissue sample without damaging the tissue and to ensure a high degree of safety for the patient. To this end, the instrument has a support means in which the probe is guided and which can be moved relative to the probe in such a way that the surrounding tissue can be counter-supported during separation of the tissue sample. The corresponding method carried out by means of the cryosurgical instrument involves separation of a tissue sample from surrounding tissue of a biological tissue to be treated. | 01-21-2010 |
20100198202 | CRYOBIOPSY PROBE - A cryosurgical instrument for separating a tissue sample from a biological tissue to be treated, for purposes of biopsy. The cryosurgical instrument includes a probe for bringing a probe head up to the biological tissue and a gas line for supplying cooling gas from a gas source of a cryosurgical apparatus to the probe head. The probe head cools a limited tissue region, by means of the supplied gas, for obtaining a tissue sample. The tissue sample can be separated from the surrounding tissue when frozen onto the probe head. The instrument has a support tube in which the probe is guided and which can be moved relative to the probe in such a way that the surrounding tissue can be supported by means of the support tube during the separating of the tissue sample. The instrument also includes an accelerating device that provides a predefined force for the separating process. | 08-05-2010 |
20100217073 | ELECTROSURGICAL INSTRUMENT, AND AN ENDOSCOPE WITH A CORRESPONDING INSTRUMENT - An electrosurgical instrument including a protective tube, to be inserted into a working channel of an endoscope, and an electrode disposed within the protective tube. The electrode is movable in a distal direction and a proximal direction inside the protective tube by a control element. By being moved in the distal direction, the electrode can be brought into a deployed position in which the electrode at least partially protrudes from a distal end of the protective tube. The distal end of the protective tube has a closure element with an opening for the passage of the electrode. The opening of the closure element has a maximum internal diameter smaller than the internal diameter of the protective tube and is used for guiding and/or cleaning the electrode. | 08-26-2010 |
20100262141 | SURGICAL INSTRUMENT FOR SEALING BLOOD VESSELS, AND HEAT-CURABLE ADHESIVE AS A MEDICAMENT - A surgical instrument including an injection device and a dosing device. These devices are designed such that a predetermined amount of an adhesive or an adhesive containing filler can be injected into a sealing section of the blood vessel. The blood vessel can then be cut at the filled point and is sealed on both sides. | 10-14-2010 |
20110028887 | WATER JET SURGICAL INSTRUMENT - A water jet surgical instrument including a supply line for supplying a cutting fluid and a discharge nozzle for forming and discharging a fluid jet, wherein the fluid jet has a predetermined spread angle and/or a predetermined emergence energy. A jet shaping device is arranged relative to the discharge nozzle such that the fluid jet is able to be adjusted by the jet shaping device with regard to the spread angle and/or emergence energy thereof. | 02-03-2011 |
20110071427 | CRYOSURGICAL INSTRUMENT FOR OBTAINING A TISSUE SAMPLE, METHOD FOR CHILLING A PROBE HEAD OF A CRYOSURGICAL PROBE - A cryosurgical instrument for obtaining a tissue sample with a probe, including the probe including a probe head onto which the tissue sample is frozen and a probe shank for guiding the probe head to the tissue sample, a supply means for supplying a fluid into an expansion chamber configured such that supplied fluid expands therein for cooling the probe head, and a removal means connected to the expansion chamber for removing the expanded fluid therefrom via at least one opening on a distal end of the probe to remove the expanded fluid to an outer region outside the probe. A method for cooling a probe head of a cryosurgical probe including supplying a fluid to an expansion chamber near the probe head, expanding the fluid so that heat energy is withdrawn from the probe head, and removing the expanded fluid in a distal region of the probe. | 03-24-2011 |
20120071868 | CRYOSURGICAL INSTRUMENT - A cryosurgical instrument, in particular a biopsy instrument for transbronchial biopsy, having an elongated instrument base body with a distal and proximal end, in relation to the operational position, a cooled section close to the distal end and which removes tissue, said section being designed such that surrounding biological material adheres thereto, by means of cryoadhesion, when said instrument is in use in the cooled state, and a security section provided at a distance from the tissue removal section and which comprises means for preventing or reducing the adhesion of biological material. | 03-22-2012 |
Mara Szyrach, Kohenberg DE
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20100273705 | Method for inhibiting "Melanoma Inhibitory Activity" MIA - The present invention is directed to peptides, antibodies and antibody fragments inhibiting activity of “Melanoma Inhibitory Activity” (MIA). | 10-28-2010 |
20120208774 | METHOD FOR INHIBITING "MELANOMA INHIBITORY ACTIVITY" MIA - The present invention is directed to peptides, antibodies and antibody fragments inhibiting activity of “Melanoma Inhibitory Activity” (MIA). | 08-16-2012 |
Mara Szyrach, Tuebingen DE
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20120303016 | ELECTROSURGICAL ASSEMBLY AND ELECTROSURGICAL INSTRUMENT - An electrosurgical assembly is disclosed having an electrosurgical instrument, a detection device for detecting a predetermined constituent of the atmosphere in the region of a treatment site and a treatment unit, which can be connected to the instrument and a current generator for providing RF energy. The treatment unit includes a mechanism for influencing the treatment process depending on an output signal of the detection device. | 11-29-2012 |
Mara Szyrach, Zuerich CH
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20140107620 | Nozzle For The Supply of Biological Material, In Particular Cells, Medical Device With Such A Nozzle, Use Of A Nozzle, Method For Mixing Fluids And Apparatus - A nozzle for the supply of biological material, in particular tissue cells, having a mixing chamber ( | 04-17-2014 |
Mara Tanelli, Milano IT
Mara Tanelli, Lodi IT
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20140046528 | Method And Electronic System For The Automatic Management Of The Energy Autonomy Of A Vehicle Particularly Of Electric Vehicles - A method is described for the automatic management of the energy autonomy of a vehicle, and includes receiving a signal for indicating a distance and/or a path to cover, and dividing the distance and/or path into space intervals; calculating an allowable variation of energy capacity in a space interval based on energy capacity detected by the sensors and on variation laws of the energy capacity; determining limit conditions for the speed and/or acceleration of the vehicle, on the basis of a map, chosen among a plurality of maps of speed-acceleration-variation of energy capacity; generating a regulated instantaneous torque request on the basis of the speed and/or acceleration detected by the plurality of sensors, of the determined limit conditions for the speed and/or acceleration and of the instantaneous torque request generated by the first central control unit. An electronic system capable of implementing such a method is described. | 02-13-2014 |
20150019062 | Pedal Assisted Bicycle And Method Of Controlling The Pedal Assisted Bicycle - A pedal assisted bicycle a first and a second wheel; a pedaling assembly mechanically decoupled from the first and second wheels by which an user can supply a pedaling power; an electric motor mechanically coupled to at least one of the wheels capable of taking a motor power; a generator device adapted to generate a generator device electric power from the pedaling power, arranged in an energy exchange relationship with the pedaling assembly and the electric motor; an energy storage device arranged in an energy exchange relationship with the electric motor and with the generator device; a control system including a module for controlling the power required to the generator device to be supplied to the electric motor and/or to the storage device; a heartbeat sensor adapted to generate a signal representing heartbeat. | 01-15-2015 |
Mara Tanelli, Milano (mi) IT
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20100299028 | METHOD FOR CONTROLLING AN ELECTRONICALLY ADJUSTABLE STEERING DAMPER FOR A TWO-WHEELED VEHICLE AND APPARATUS IMPLEMENTING IT - The present invention refers to a method for controlling an electronically adjustable steering damper in a two-wheeled vehicle or motor vehicle, and to an apparatus implementing it, in which the steering damper is able to exert a damping torque on a steering assembly ( | 11-25-2010 |
Mara Treglia, Zurich CH
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20080217152 | HIGH-VOLTAGE CIRCUIT BREAKER AND SWITCH ARRANGEMENT - The disclosure relates to an electrical switching device, e.g., a high-voltage switch, with a mantle-side electrical connection. According to the disclosure, an encapsulated angle disconnector is fitted between the mantle-side electrical connection and the outdoor bushing or an outgoing cable, by means of which angle disconnector the electrical connection is deflected in the disconnector plane, e.g., toward the vertical in the operating position of the switching device. Exemplary embodiments relate, inter alia, to: a horizontal electrical connection and a, 90° disconnector; an additional tilting angle (β) of the angle disconnector about the disconnector input axis; a plurality of mantle-side horizontal electrical connections with associated angle disconnectors, which are tilted away from one another. | 09-11-2008 |
Mara Vanvorst, Scotia, NY US
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20090014974 | WHEELED SKI AND EQUIPMENT-CARRYING DEVICE - A ski bag incorporated with a frame having wheels and a handle, capable of holding a family's skis and/or snowboard(s), enabling them to wheel the bag to a lodge, automobile, etc.; and which may be easily stored in a typical ski locker. | 01-15-2009 |
Mara Zesi, Grugliasco (torino) IT
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20110174345 | Device for dispensing at least one washing agent in a dishwashing machine - The dispensing device includes a support body adapted to be mounted on the side of that door of the machine which is facing the washing chamber, in a position such that in the operation this body is periodically flushed, at least in part, by a flow of washing liquid emitted by at least one spraying rotor. In the support body there is incorporated an electrically conducting member whose electric capacitance with respect to earth is variable by the effect of the flow of washing liquid which periodically impinges onto the body; a detection and processing device being connected to the conducting member and being predisposed for detecting the variations of the electric capacitance of said conducting member with respect to earth and for correlating in a predetermined manner said variations with the operation of the spraying rotor. | 07-21-2011 |
Mara Zippoli, L`aquila IT
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20140371274 | BRADYKININ RECEPTOR ANTAGONISTS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM - The present invention relates to novel compounds, their use in the prevention or treatment of symptoms and disorders associated with the bradykinin B | 12-18-2014 |
María Aguirregabiria Izaguirre, Guipuzcoa ES
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20100304306 | FLEXIBLE MICRO/NANOFLUIDIC DEVICES - The present invention relates to a method for manufacturing micro/nanofluidic devices that incorporate overhanging micromechanical and metal components monolithically integrated with the fluidic circuitry. | 12-02-2010 |
María Aguirregabiria Izaguirre, Guipuzcoa ES
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20100304306 | FLEXIBLE MICRO/NANOFLUIDIC DEVICES - The present invention relates to a method for manufacturing micro/nanofluidic devices that incorporate overhanging micromechanical and metal components monolithically integrated with the fluidic circuitry. | 12-02-2010 |
María Garranzo García-Ibarrola, Madrid ES
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20110034549 | Antitumoral Compounds - A compound of general formula (I) | 02-10-2011 |
20120190870 | ANTITUMORAL DIHYDROPYRAN-2-ONE COMPOUNDS - Antitumoral compounds obtained from a porifera, of the family Raspailiidae, genus | 07-26-2012 |
María Garranzo García-Ibarrola, Madrid ES
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20090186938 | ANTITUMORAL DIHYDROPYRAN-2-ONE COMPOUNDS - Antitumoral compounds obtained from a porifera, of the family Raspailiidae, genus | 07-23-2009 |
20100048690 | ANTITUMORAL DIHYDROPYRAN-2-ONE COMPOUNDS - Antitumoral compounds obtained from a porifera, of the family Raspailiidae, genus | 02-25-2010 |
20100280108 | Antitumoral Compounds - A compound of general formula (I) | 11-04-2010 |
20110034549 | Antitumoral Compounds - A compound of general formula (I) | 02-10-2011 |
20120041063 | ANTITUMORAL COMPOUNDS - A compound of general formula (I) | 02-16-2012 |
María Iñiguez Martínez, Pamplona ES
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20130130225 | COMPOSITION FOR THE COLD STORAGE OF ORGANS - The present invention relates to a cold organ preservation composition for transplantation comprising a cold organ preservation solution and cardiotrophin-1 or a functionally equivalent variant thereof. The invention also relates to methods and kits for the preparation of said composition, the uses thereof for the cold organ protection and/or preservation for transplantation (particularly for kidney, lung and heart) and also to the cold preservation methods and cold-preserved isolated organs by these methods. | 05-23-2013 |
María Jordá Beneyto, Paterna ES
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20130143988 | MODIFIED PHYLLOSILICATE - Polymer nanocomposites including: a) a polylactic polymer; and b) a modified phyllosilicate composition including a modifying agent which includes hexadecyl trimethyl ammonium cations which are intercalated between the layers of the phyllosilicate, and preparation processes therefor, as well as the modified phyllosilicate composition. The polymer nanocomposites are particularly useful for packaging, particularly food and drink packaging. | 06-06-2013 |
20130177723 | POLYMER NANOCOMPOSITE COMPRISING POLYLACTIC ACID REINFORCED WITH THE MODIFIED PHYLLOSILICATE - Polymer nanocomposite having: a) a polylactic polymer; and b) a modified phyllosilicate composition having a modifying agent which includes hexadecyl trimethyl ammonium cations which are intercalated between the layers of the phyllosilicate; and preparation process of such a polymer nanocomposite. The polymer nanocomposite is particularly useful for packaging, particularly food and drink packaging. | 07-11-2013 |
María Luz Martín-Martín, Toledo ES
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20130245043 | SUBSTITUTED IMIDAZOPYRIMIDIN-5(6H)-ONES AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS - In one aspect, the invention relates to imidazopyrimidin-5(6H)-one analogs, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. | 09-19-2013 |
María Morales Areizaga, Madrid ES
María Ortega Muñoz, Toledo ES
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20120252688 | NOVEL BIOMARKERS OF DISEASE HISTOPATHOLOGY - Use of FGF-2 and Anosmin-1 proteins to predict the histopathology of the lesions of a subject with a demyelinating disease of the central nervous system (CNS) by detecting the amount of such proteins in a sample of isolated biological fluid. Furthermore, the present invention relates to a method for the understanding of the histopathological features of the lesions of a subject with a CNS demyelinating disease a kit to carry out this method. Preferably, the CNS demyelinating disease is multiple sclerosis, and the biological fluid is cerebrospinal fluid (CSF). | 10-04-2012 |
María Pedrero Muñoz, Madrid ES
María Prat Quiñones, Barcelona ES
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20120122826 | NOVEL QUINUCLIDINE DERIVATIVES AND MEDICINAL COMPOSITIONS CONTAINING THE SAME - The invention provides 3-(2-hydroxy-2,2-dithien-2-ylacetoxy)-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2]octane bromide in combination with a steroid, and methods of using it for treatment of respiratory disorders. | 05-17-2012 |
María Tijero Serna, Mondragon ES
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20100327211 | METHOD FOR THE PRODUCTION OF MICRO/NANOFLUIDIC DEVICES FOR FLOW CONTROL AND RESULTING DEVICE - The present invention refers to a procedure for the manufacture of micro-nanofluidic devices for flow control such as microvalves, micropumps and flow regulators, using a photodefinable polymer and an elastomer as structural materials and to the micro-nanofluidic devices for flow control obtained by said procedure. | 12-30-2010 |
María Tijero Serna, Mondragon ES
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20100327211 | METHOD FOR THE PRODUCTION OF MICRO/NANOFLUIDIC DEVICES FOR FLOW CONTROL AND RESULTING DEVICE - The present invention refers to a procedure for the manufacture of micro-nanofluidic devices for flow control such as microvalves, micropumps and flow regulators, using a photodefinable polymer and an elastomer as structural materials and to the micro-nanofluidic devices for flow control obtained by said procedure. | 12-30-2010 |