Patent application number | Description | Published |
20150239331 | SYSTEM FOR ABSORBING AND DISTRIBUTING SIDE IMPACT ENERGY UTILIZING AN INTEGRATED BATTERY PACK - An energy absorbing and distributing side impact system for a vehicle includes: first and second side sills, each of the first and second sills comprising multiple longitudinal channels, at least an upper longitudinal channel positioned above a vehicle floor panel and at least a lower longitudinal channel positioned below the vehicle floor panel; a battery enclosure mounted between front and rear suspensions of the vehicle, the battery enclosure having a first side member attached to the first side sill, and a second side member attached to the second side sill; cross-members integrated into the battery enclosure; and one or more bolts each extending though a respective opening in one of the cross-members and extending to an opposite side of the vehicle floor panel from the cross-member. | 08-27-2015 |
20150307068 | BATTERY SWAPPING SYSTEM AND TECHNIQUES - A method of exchanging an electrical energy storage system (EESS) in an electric vehicle includes: positioning an electric vehicle in x and y directions on an EESS exchange station; after positioning, raising the electric vehicle to a predetermined height using a first lift; after raising the electric vehicle, raising an EESS lift toward the electric vehicle until the EESS lift is correctly positioned relative to a first EESS; after raising the EESS lift, removing fasteners that secure a first EESS to the electric vehicle; placing an EESS conveyor underneath the EESS lift; after placing the EESS conveyor, lowering the first EESS onto the EESS conveyor using the EESS lift; after lowering the first EESS, removing the first EESS and instead placing a second EESS underneath the electric vehicle; after placing the second EESS underneath the electric vehicle, raising the second EESS toward the electric vehicle using the EESS lift until the second EESS is correctly positioned relative to the electric vehicle; after raising the second EESS, fastening the second EESS onto the electric vehicle; and after fastening the second EESS, lowering the electric vehicle using the vehicle lift. | 10-29-2015 |
Patent application number | Description | Published |
20120161429 | Augmented Vehicle Seat Mount - A vehicle seat mounting assembly is provided in which the seat mounts are attached to body cross-members that are, in turn, mechanically coupled to battery pack cross-members contained within a battery pack enclosure mounted under the vehicle. | 06-28-2012 |
20120161472 | System for Absorbing and Distributing Side Impact Energy Utilizing an Integrated Battery Pack - An energy absorbing and distributing side impact system for use with a vehicle is provided, the system utilizing a battery pack enclosure that includes a plurality of cross-members that transverse the battery pack enclosure and absorb and distribute at least a portion of the load received when either the first or second side of the vehicle receives a side impact. The battery pack enclosure is positioned between the front and rear vehicle suspension assemblies and mounted between, and mechanically coupled to, vehicle structural members (e.g., rocker panels) located on either side of the vehicle. In addition to providing rigidity, strength and impact resistance, the battery pack cross-members segregate the batteries contained within the battery pack enclosure into battery groups. | 06-28-2012 |
20130088044 | System for Absorbing and Distributing Side Impact Energy Utilizing an Integrated Battery Pack and Side Sill Assembly - An energy absorbing and distributing side impact system for use with a vehicle is provided, the system utilizing a collapsible side sill along with multiple vehicle cross-members to achieve the desired level of vehicle side impact resistance, the combination of these elements absorbing and distributing the impact load throughout the vehicle structure. A battery pack enclosure that includes a plurality of cross-members that transverse the battery pack enclosure also help to absorb and distribute at least a portion of the load received when either the first or second side of the vehicle receives a side impact. In this configuration the battery pack enclosure is positioned between the front and rear vehicle suspension assemblies and mounted between, and mechanically coupled to, the side sill assemblies. In addition to providing rigidity, strength and impact resistance, the battery pack cross-members segregate the batteries contained within the battery pack enclosure into battery groups. | 04-11-2013 |
20130088045 | System for Absorbing and Distributing Side Impact Energy Utilizing a Side Sill Assembly with a Collapsible Sill Insert - An energy absorbing and distributing side impact system for use with a vehicle is provided, the system utilizing a collapsible side sill assembly along with multiple vehicle cross-members to achieve the desired level of vehicle side impact resistance, the combination of these elements absorbing and distributing the impact load throughout the vehicle structure. The collapsible side sill assembly includes a side sill insert, the insert divided into a collapsible portion designed to absorb impact energy and a reacting portion designed to distribute the impact energy to the vehicle cross-members. | 04-11-2013 |
20140182958 | SYSTEM FOR ABSORBING AND DISTRIBUTING SIDE IMPACT ENERGY UTILIZING AN INTEGRATED BATTERY PACK - An energy absorbing and distributing side impact system for use with a vehicle is provided, the system utilizing a battery pack enclosure that includes a plurality of cross-members that transverse the battery pack enclosure and absorb and distribute at least a portion of the load received when either the first or second side of the vehicle receives a side impact. The battery pack enclosure is positioned between the front and rear vehicle suspension assemblies and mounted between, and mechanically coupled to, vehicle structural members (e.g., rocker panels) located on either side of the vehicle. In addition to providing rigidity, strength and impact resistance, the battery pack cross-members segregate the batteries contained within the battery pack enclosure into battery groups. | 07-03-2014 |
Patent application number | Description | Published |
20100191609 | SYSTEM AND METHOD FOR PROVIDING ACCESS TO REMOTELY STORED DIGITAL MEDIA USING AN RSS FEED - A system and method for providing digital media content involves use of custom URIs, disguised as URLs, provided as media enclosures in an RSS feed, for the purpose of redirecting requests for digital media content from a customer computer to an intermediate transaction server. The transaction server intercepts the custom URI containing customer, item, price and/or other relevant information to translate the file request into a transaction record and serve up the appropriate file, possibly from a remote merchant site, for the request and customer. When the transaction server receives a request for the custom URI, it parses it according to pre-defined rules and serves the appropriate file to the requester and records the transaction. This approach can be used to aggregate small transactions of digital content. Customers have a revolving account with the transaction server and can aggregate purchases from multiple merchants via RSS delivery up to preset limits. | 07-29-2010 |
20130073452 | SYSTEM AND METHOD FOR PROVIDING ACCESS TO REMOTELY STORED DIGITAL MEDIA USING AN RSS FEED - A system and method for providing digital media content involves use of custom URIs, disguised as URLs, provided as media enclosures in an RSS feed, for the purpose of redirecting requests for digital media content from a customer computer to an intermediate transaction server. The transaction server intercepts the custom URI containing customer, item, price and/or other relevant information to translate the file request into a transaction record and serve up the appropriate file, possibly from a remote merchant site, for the request and customer. When the transaction server receives a request for the custom URI, it parses it according to pre-defined rules and serves the appropriate file to the requester and records the transaction. This approach can be used to aggregate small transactions of digital content. Customers have a revolving account with the transaction server and can aggregate purchases from multiple merchants via RSS delivery up to preset limits. | 03-21-2013 |
Patent application number | Description | Published |
20100248702 | Methods and system for enhanced directory assistance using wireless messaging protocols - Directory assistance provides telephone number look up services to callers based on the business or caller name as listed in a telephone directory. In the prior art, directory assistance provides a value-added service to telephone users and an expense that must be charged back to telephone callers or absorbed by telephone carriers. In enhanced directory assistance (EDA) services as described in the disclosure, EDA is further developed to deliver a keyword targeted advertising service to telephone listing owners and advertisers. The present invention provides a method and system to extend EDA services to the wireless messaging systems used by telecommunications operators. The invention further discloses methods to support both one-way and two-way communications on these devices, as well as systems to support the distributed EDA Transaction business model. | 09-30-2010 |
20110173057 | METHODS AND SYSTEMS FOR A DYNAMIC NETWORKED COMMERCE ARCHITECTURE - One embodiment of the present invention provides systems and methods, which allow a more efficient shopping experience. A cascading commerce menu provides access to a plurality of product, service, and/or content categories. In one embodiment, the cascading commerce menu is stored on a client computer, thereby providing quick access to the menu. | 07-14-2011 |
20130137395 | METHODS AND SYSTEMS FOR ENHANCED DIRECTORY ASSISTANCE USING WIRELESS MESSAGING PROTOCOLS - Directory assistance provides telephone number look up services to callers based on the business or caller name as listed in a telephone directory. In the prior art, directory assistance provides a value-added service to telephone users and an expense that must be charged back to telephone callers or absorbed by telephone carriers. In enhanced directory assistance (EDA) services as described in the disclosure, EDA is further developed to deliver a keyword targeted advertising service to telephone listing owners and advertisers. The present invention provides a method and system to extend EDA services to the wireless messaging systems used by telecommunications operators. The invention further discloses methods to support both one-way and two-way communications on these devices, as well as systems to support the distributed EDA Transaction business model. | 05-30-2013 |
20140161246 | METHODS AND SYSTEMS FOR ENHANCED DIRECTORY ASSISTANCE USING WIRELESS MESSAGING PROTOCOLS - Directory assistance provides telephone number look up services to callers based on the business or caller name as listed in a telephone directory. In the prior art, directory assistance provides a value-added service to telephone users and an expense that must be charged back to telephone callers or absorbed by telephone carriers. In enhanced directory assistance (EDA) services as described in the disclosure, EDA is further developed to deliver a keyword targeted advertising service to telephone listing owners and advertisers. The present invention provides a method and system to extend EDA services to the wireless messaging systems used by telecommunications operators. The invention further discloses methods to support both one-way and two-way communications on these devices, as well as systems to support the distributed EDA Transaction business model. | 06-12-2014 |
20140236691 | METHODS AND SYSTEMS FOR A DYNAMIC NETWORKED COMMERCE ARCHITECTURE - One embodiment of the present invention provides systems and methods, which allow a more efficient shopping experience. A cascading commerce menu provides access to a plurality of product, service, and/or content categories. In one embodiment, the cascading commerce menu is stored on a client computer, thereby providing quick access to the menu. | 08-21-2014 |
Patent application number | Description | Published |
20130077044 | Eye Covering and Refractive Correction Methods and Apparatus Having Improved Tear Flow, Comfort, and/or Applicability - An eye covering such as a contact lens may comprise one or more structures to pump tear liquid under the covering such that the covering can remain in the eye and correct vision for an extended amount of time. In many embodiments, the covering comprises a material having fenestrations to draw tear liquid under the covering and an outer portion shaped to contact the conjunctiva over the sclera, such that when the eye closes pressure of one or more eyelids urges tear liquid through one or more fenestrations and under the outer portion shaped to contact the conjunctiva. When the eye blinks, the pressure of the one or more eyelids can urge the covering toward the cornea such that tear liquid can pass through the fenestrations. | 03-28-2013 |
20130278890 | CONTACT LENSES FOR DIFFRACTIVE CORRECTION - Ophthalmic lenses for correcting refractive error of an eye are disclosed. Ophthalmic lenses include a deformable inner portion and a deformable peripheral portion. When disposed over the optical region of an eye, the inner portion is configured so that engagement of the posterior surface against the eye deforms the posterior surface so that the posterior surface has a shape diverging form the refractive shape of the epithelium when viewing with the eye through the ophthalmic lens. The rigidity of the inner portion is greater than the rigidity of the peripheral portion and the ophthalmic lenses are configured to allow movement relative to the eye upon blinking of the eye and to be substantially centered on the optical region of the cornea following the blinking of the eye. Methods of correcting refractive errors of an eye such as astigmatism or spherical aberration using the ophthalmic lenses are also disclosed. | 10-24-2013 |
20130293832 | CONTACT LENSES FOR REFRACTIVE CORRECTION - Ophthalmic lenses for correcting refractive error of an eye are disclosed. Ophthalmic lenses include a deformable inner portion and a deformable peripheral portion. When disposed over the optical region of an eye, the inner portion is configured so that engagement of the posterior surface against the eye deforms the posterior surface so that the posterior surface has a shape diverging form the refractive shape of the epithelium when viewing with the eye through the ophthalmic lens. The rigidity of the inner portion is greater than the rigidity of the peripheral portion and the ophthalmic lenses are configured to allow movement relative to the eye upon blinking of the eye and to be substantially centered on the optical region of the cornea following the blinking of the eye. Methods of correcting refractive errors of an eye such as astigmatism or spherical aberration using the ophthalmic lenses are also disclosed. | 11-07-2013 |
20140069438 | CONFORMABLE THERAPEUTIC SHIELD FOR VISION AND PAIN - A conformable covering comprises an outer portion with rigidity to resist movement on the cornea and an inner portion to contact the cornea and provide an environment for epithelial regeneration. The inner portion of the covering can be configured in many ways so as to conform at least partially to an ablated stromal surface so as to correct vision. The conformable inner portion may have at least some rigidity so as to smooth the epithelium such that the epithelium regenerates rapidly and is guided with the covering so as to form a smooth layer for vision. The inner portion may comprise an amount of rigidity within a range from about 1×10-4 Pa*m3 to about 5×10-4 Pa*m3 so as to deflect and conform at least partially to the ablated cornea and smooth an inner portion of the ablation with an amount of pressure when deflected. | 03-13-2014 |
20140069439 | EYE COVERING AND REFRACTIVE CORRECTION METHODS FOR LASIK AND OTHER APPLICATIONS - A method for providing faster visual and functional recovery of patients following refractive surgery such as laser assisted in situ keratomileusis (LASIK) is disclosed. The method comprises providing a covering to the eye of a patient comprising an inner portion having an inner rigidity and at least one inner radius of curvature; and an outer portion having an outer rigidity and at least one outer radius of curvature; wherein the inner rigidity is greater than the outer rigidity. | 03-13-2014 |
20140155800 | EYE COVERINGS FOR CORNEAL HEALING AND METHODS OF USE - Methods for providing faster visual and functional recovery of patients following ocular therapy such as ocular therapy involving manipulation of the ocular tissue and/or associated with a lesion external to the optical region and ocular therapy involving incising the ocular tissue and implanting a device within the optical region are disclosed. Methods of healing a trauma wound to a cornea and methods of protecting an eye of a patient from potential injury are also disclosed. The disclosed methods comprise providing a covering to the eye of a patient wherein the covering comprises an inner portion having an inner rigidity and at least one inner radius of curvature; and an outer portion having an outer rigidity and at least one outer radius of curvature; wherein the inner rigidity is greater than the outer rigidity. | 06-05-2014 |
20140251347 | CONFORMABLE THERAPEUTIC SHIELD FOR VISION AND PAIN - A conformable covering comprises an outer portion with rigidity to resist movement on the cornea and an inner portion to contact the cornea and provide an environment for epithelial regeneration. The inner portion of the covering can be configured in many ways so as to conform at least partially to an ablated stromal surface so as to correct vision. The conformable inner portion may have at least some rigidity so as to smooth the epithelium such that the epithelium regenerates rapidly and is guided with the covering so as to form a smooth layer for vision. The inner portion may comprise an amount of rigidity within a range from about 1×10−4 Pa*m3 to about 5×10−4 Pa*m3 so as to deflect and conform at least partially to the ablated cornea and smooth an inner portion of the ablation with an amount of pressure when deflected. | 09-11-2014 |
20140362338 | EYE COVERING AND REFRACTIVE CORRECTION METHODS AND APPARATUS HAVING IMPROVED TEAR FLOW, COMFORT, AND/OR APPLICABILITY - An eye covering such as a contact lens may comprise one or more structures to pump tear liquid under the covering such that the covering can remain in the eye and correct vision for an extended amount of time. In many embodiments, the covering comprises a material having fenestrations to draw tear liquid under the covering and an outer portion shaped to contact the conjunctiva over the sclera, such that when the eye closes pressure of one or more eyelids urges tear liquid through one or more fenestrations and under the outer portion shaped to contact the conjunctiva. When the eye blinks, the pressure of the one or more eyelids can urge the covering toward the cornea such that tear liquid can pass through the fenestrations. | 12-11-2014 |
20150055081 | BIMODULAR CONTACT LENSES - Ophthalmic lenses for correcting refractive error of an eye are disclosed. Ophthalmic lenses include an inner optic portion configured to be disposed over the optical region of the cornea and having a central portion disposed between an anterior portion and a posterior portion. The inner optic portion is configured to at least partially diverge from the shape of the cornea to provide at least one lenticular volume between a posterior surface of the inner optic portion and the cornea. The central portion may be characterized by a thickness from 50 μm to 900 μm and a modulus form 20 MPa to 1500 MPa. | 02-26-2015 |
20150077701 | CONTACT LENSES FOR REFRACTIVE CORRECTION - Ophthalmic lenses for correcting refractive error of an eye are disclosed. Ophthalmic lenses include a deformable inner portion and a deformable peripheral portion. When disposed over the optical region of an eye, the inner portion is configured so that engagement of the posterior surface against the eye deforms the posterior surface so that the posterior surface has a shape diverging form the refractive shape of the epithelium when viewing with the eye through the ophthalmic lens. The rigidity of the inner portion is greater than the rigidity of the peripheral portion and the ophthalmic lenses are configured to allow movement relative to the eye upon blinking of the eye and to be substantially centered on the optical region of the cornea following the blinking of the eye. Methods of correcting refractive errors of an eye such as astigmatism or spherical aberration using the ophthalmic lenses are also disclosed. | 03-19-2015 |
20150138500 | CONTACT LENSES HAVING A REINFORCING SCAFFOLD - Ophthalmic lenses for correcting refractive error of an eye are disclosed. Ophthalmic lenses include an inner optic portion having a scaffold between an anterior portion and a posterior portion. The scaffold is characterized by a substantially uniform thickness formed from a material characterized by a modulus that his higher than the modulus of the peripheral portion. Openings within the scaffold are filled with a low modulus material. When applied to an eye, the lenses are configured to provide one or more lenticular volumes between the posterior surface of the lens and the cornea. The disclosure further relates to methods of correcting refractive errors of an eye such as astigmatism or spherical aberration using the ophthalmic lenses. | 05-21-2015 |
Patent application number | Description | Published |
20120310133 | Conformable Therapeutic Shield for Vision and Pain - A conformable covering comprises an outer portion with rigidity to resist movement on the cornea and an inner portion to contact the cornea and provide an environment for epithelial regeneration. The inner portion of the covering can be configured in many ways so as to conform at least partially to an ablated stromal surface so as to correct vision. The conformable inner portion may have at least some rigidity so as to smooth the epithelium such that the epithelium regenerates rapidly and is guided with the covering so as to form a smooth layer for vision. The inner portion may comprise an amount of rigidity within a range from about 1×10-4 Pa*m3 to about 5×10-4 Pa*m3 so as to deflect and conform at least partially to the ablated cornea and smooth an inner portion of the ablation with an amount of pressure when deflected. | 12-06-2012 |
20130025606 | Conformable Therapeutic Shield for Vision and Pain - A conformable covering comprises an outer portion with rigidity to resist movement on the cornea and an inner portion to contact the cornea and provide an environment for epithelial regeneration. The inner portion of the covering can be configured in many ways so as to conform at least partially to an ablated stromal surface so as to correct vision. The conformable inner portion may have at least some rigidity so as to smooth the epithelium such that the epithelium regenerates rapidly and is guided with the covering so as to form a smooth layer for vision. The inner portion may comprise an amount of rigidity within a range from about 1×10−4 Pa*m3 to about 5×10−4 Pa*m3 so as to deflect and conform at least partially to the ablated cornea and smooth an inner portion of the ablation with an amount of pressure when deflected. | 01-31-2013 |
20130070200 | Conformable Therapeutic Shield for Vision and Pain - A conformable covering comprises an outer portion with rigidity to resist movement on the cornea and an inner portion to contact the cornea and provide an environment for epithelial regeneration. The inner portion of the covering can be configured in many ways so as to conform at least partially to an ablated stromal surface so as to correct vision. The conformable inner portion may have at least some rigidity so as to smooth the epithelium such that the epithelium regenerates rapidly and is guided with the covering so as to form a smooth layer for vision. The inner portion may comprise an amount of rigidity within a range from about 1×10−4 Pa*m3 to about 5×10−4 Pa*m3 so as to deflect and conform at least partially to the ablated cornea and smooth an inner portion of the ablation with an amount of pressure when deflected. | 03-21-2013 |
20140028979 | METHODS AND APPARATUS TO IDENTIFY EYE COVERINGS FOR VISION - Methods and apparatus can fit coverings to treat eyes. The covering can be identified so as to provide improved flow of tear liquid under the covering. The covering can be identified based on an inner corneal curvature and an outer corneal curvature and one or more of a limbus sag height or a conjunctival sag height. The covering may form a chamber when placed on the eye to pump tear liquid under at least a portion of the covering. The covering may comprise an outer portion with rigidity to resist movement on the cornea and an inner portion to contact the cornea and provide an environment for epithelial regeneration. The covering may comprise a material having high oxygen permeability, for example silicone, with a wettable coating disposed on at least an upper surface of the coating. | 01-30-2014 |
20160067109 | CONFORMABLE THERAPEUTIC SHIELD FOR VISION AND PAIN - A conformable covering comprises an outer portion with rigidity to resist movement on the cornea and an inner portion to contact the cornea and provide an environment for epithelial regeneration. The inner portion of the covering can be configured in many ways so as to conform at least partially to an ablated stromal surface so as to correct vision. The conformable inner portion may have at least some rigidity so as to smooth the epithelium such that the epithelium regenerates rapidly and is guided with the covering so as to form a smooth layer for vision. The inner portion may comprise an amount of rigidity within a range from about 1×10-4 Pa*m3 to about 5×10-4 Pa*m3 so as to deflect and conform at least partially to the ablated cornea and smooth an inner portion of the ablation with an amount of pressure when deflected. | 03-10-2016 |
Patent application number | Description | Published |
20110123493 | 2,4,6-TRISUBSTITUTED PYRIDO(3,2-d) PYRIMIDINES USEFUL FOR TREATING VIRAL INFECTIONS - Pyrido(3,2-d)pyrimidine derivatives represented by the structural formula (Ia): wherein, R | 05-26-2011 |
20110178058 | INHIBITORS OF FLAVIVIRIDAE VIRUSES - Provided are compounds of Formula I: | 07-21-2011 |
20110178129 | INHIBITORS OF FLAVIVIRIDAE VIRUSES - Provided are compounds of Formula I: | 07-21-2011 |
20120156166 | INHIBITORS OF FLAVIVIRIDAE VIRUSES - Provided are compounds of Formula I: and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections, particularly hepatitis C infections. | 06-21-2012 |
20130053577 | ANTIVIRAL COMPOUNDS - The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds. | 02-28-2013 |
Patent application number | Description | Published |
20090257978 | Antiviral coumpounds - The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds. | 10-15-2009 |
20110020278 | INHIBITORS OF FLAVIVIRIDAE VIRUSES - Provided are compounds of Formula I: | 01-27-2011 |
20110135599 | ANTIVIRAL COMPOUNDS - The present application includes novel inhibitors of HCV, compositions containing such compounds, therapeutic methods that include the administration of such compounds. | 06-09-2011 |
20120107274 | 2'-FLUORO SUBSTITUTED CARBA-NUCLEOSIDE ANALOGS FOR ANTIVIRAL TREATMENT - Provided are methods for treating Orthomyxoviridae virus infections by administering ribosides, riboside phosphates and prodrugs thereof, of Formula I: | 05-03-2012 |
20120190866 | ANTIVIRAL COMPOUNDS - The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds. | 07-26-2012 |
20130243725 | 2'-SUBSTITUTED CARBA-NUCLEOSIDE ANALOGS FOR ANTIVIRAL TREATMENT - Provided are compounds of Formula I, | 09-19-2013 |
20130274439 | ANTIVIRAL COMPOUNDS - The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds. | 10-17-2013 |
20130281686 | METHODS FOR THE PREPARATION OF DIASTEROMERICALLY PURE PHOSPHORAMIDATE PRODRUGS - Provided are methods and intermediates for preparing diastereomerically pure phosphoramidate prodrugs of nucleosides of Formulas Ia and Ib: | 10-24-2013 |
20130302280 | INHIBITORS OF FLAVIVIRIDAE VIRUSES - Provided are compounds of Formula I: and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections, particularly hepatitis C infections. | 11-14-2013 |
20130315861 | INHIBITORS OF FLAVIVIRIDAE VIRUSES - Provided are compounds of Formula I: | 11-28-2013 |
20140030223 | INHIBITORS OF FLAVIVIRIDAE VIRUSES - Provided are compounds of Formula I: | 01-30-2014 |
20140200188 | 2'-FLUORO SUBSTITUTED CARBA-NUCLEOSIDE ANALOGS FOR ANTIVIRAL TREATMENT - Provided are methods for treating Orthomyxoviridue virus infections by administering ribosides, riboside phosphates and prodrugs thereof, of Formula I: | 07-17-2014 |
20150080569 | ANTIVIRAL COMPOUNDS - The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds. | 03-19-2015 |
20150133395 | PYRROLO[1,2-f][1,2,4]TRIAZINES USEFUL FOR TREATING RESPIRATORY SYNCITIAL VIRUS INFECTIONS - Provided herein are formulations, methods and substituted tetrahydrofuranyl-pyrrolo[1,2-f][1,2,4]triazine-4-amine compounds of Formula (I) for treating Pneumovirinae virus infections, including respiratory syncytial virus infections, as well as methods and intermediates for synthesis of tetrahydrofuranyl-pyrrolo[1,2-f][1,2,4]triazine-4-amine compounds. | 05-14-2015 |
20160024107 | THIENO[3,2-d]PYRIMIDINE, FURO[3,2-d]PYRIMIDINE, AND PYRROLO[3,2-D]PYRIMIDINES USEFUL FOR TREATING RESPIRATORY SYNCITIAL VIRUS INFECTIONS - Provided herein are formulations, methods and substituted thieno[3,2-d]pyrimidine, furo[3,2-d]pyrimidine, and pyrrolo[3,2-d]pyrimidine compounds of Formula (I) for treating Pneumovirinae virus infections, including respiratory syncytial virus infections, as well as methods and intermediates for synthesis of substituted thieno[3,2-d]pyrimidine, furo[3,2-d]pyrimidine, and pyrrolo[3,2-d]pyrimidine compounds. | 01-28-2016 |
20160052953 | 2'-CHLORO AMINOPYRIMIDINONE AND PYRIMIDINE DIONE NUCLEOSIDES - Provided herein are formulations, methods and substituted 2′-chloro aminopyrimidinone and pyrimidine dione compounds of Formula (I) for treating Pneumovirinae virus infections, including respiratory syncytial virus infections, as well as methods and intermediates for synthesis of substituted 2′-chloro aminopyrimidinone and pyrimidine dione compounds. | 02-25-2016 |
Patent application number | Description | Published |
20110111512 | QUANTITATION OF INSULIN-LIKE GROWTH FACTOR-I AND INSULIN-LIKE GROWTH FACTOR-II WITH HIGH-RESOLUTION MASS SPECTROMETRY - Methods are provided for determining the amount of an IGF-I and/or IGF-II protein in a sample using high resolution/high accuracy mass spectrometry. The methods generally comprise enriching an IGF-I and/or IGF-II protein in a sample, ionizing an IGF-I and/or IGF-II protein from the sample to generate IGF-I and/or IGF-II protein ions, and determining the amount of IGF-I and/or IGF-II protein ions with high resolution/high accuracy mass spectrometry. | 05-12-2011 |
20110133068 | VITAMIN D METABOLITE DETERMINATION UTILIZING MASS SPECTROMETRY FOLLOWING DERIVATIZATION - The invention relates to the detection of vitamin D metabolites. In a particular aspect, the invention relates to methods for detecting derivatized vitamin D metabolites by mass spectrometry. | 06-09-2011 |
20110133069 | METHODS FOR DETECTING DIHYDROXYVITAMIN D METABOLITES BY MASS SPECTROMETRY - Provided are methods of detecting the presence or amount of a dihydroxyvitamin D metabolite in a sample using mass spectrometry. The methods generally comprise ionizing a dihydrorxyvitamin D metabolite in a sample and detecting the amount of the ion to determine the presence or amount of the vitamin D metabolite in the sample. In certain preferred embodiments the methods include immunopurifying the dihydroxyvitamin D metabolites prior to mass spectrometry. Also provided are methods to detect the presence or amount of two or more dihydroxyvitamin D metabolites in a single assay. | 06-09-2011 |
20110220785 | METHODS FOR DETECTING VITAMIN D METABOLITES BY MASS SPECTROMETRY - Provided are methods of detecting the presence or amount of a vitamin D metabolite in a sample using mass spectrometry. The methods generally comprise ionizing a vitamin D metabolite in a sample and detecting the amount of the ion to determine the presence or amount of the vitamin D metabolite in the sample. Also provided are methods to detect the presence or amount of two or more vitamin D metabolites in a single assay. | 09-15-2011 |
20110226944 | VITAMIN D METABOLITE DETERMINATION UTILIZING MASS SPECTROMETRY FOLLOWING DERIVATIZATION - The invention relates to the detection of vitamin D metabolites. In a particular aspect, the invention relates to methods for detecting derivatized vitamin D metabolites by mass spectrometry. | 09-22-2011 |
20110240840 | MASS SPECTROMETRIC DETERMINATION OF COOKSON-DERIVATIZED, NON-METABOLIZED VITAMIN D - The invention relates to the detection of vitamin D. In a particular aspect, the invention relates to methods for detecting derivatized vitamin D by mass spectrometry. | 10-06-2011 |
20110248158 | METHODS FOR DETECTING DIHYDROXYVITAMIN D METABOLITES BY MASS SPECTROMETRY - Provided are methods of detecting the presence or amount of a dihydroxyvitamin D metabolite in a sample using mass spectrometry. The methods generally comprise ionizing a dihydroxyvitamin D metabolite in a sample and detecting the amount of the ion to determine the presence or amount of the vitamin D metabolite in the sample. In certain preferred embodiments the methods include immunopurifying the dihydroxyvitamin D metabolites prior to mass spectrometry. Also provided are methods to detect the presence or amount of two or more dihydroxyvitamin D metabolites in a single assay. | 10-13-2011 |
20110290999 | MONOLITHIC COLUMN CHROMATOGRAPHY - Provided herein are methods of liquid column chromatography in which preparative chromatography is performed in-line with analytical chromatography. In particular aspects a monolithic preparative column is used to purify an analyte of interest from a mixture of other substances by applying the mixture to the column, reversing the flow through the column to elute the analyte, which is applied to an analytical column provided in-line with the preparative column. In other aspects, a single monolithic column is used to perform both the preparative chromatography and analytical chromatography steps in succession. In another aspect, a chromatography system is provided to perform preparative and analytical chromatography using a single monolithic column. | 12-01-2011 |
20120025067 | MASS SPECTROMETRIC DETERMINATION OF NON-DERIVATIZED, NON-METABOLIZED VITAMIN D - The invention relates to the detection of non-metabolized vitamin D. In a particular aspect, the invention relates to methods for detecting underivatized non-metabolized vitamin D by mass spectrometry. | 02-02-2012 |
20120061562 | METHODS FOR DETECTING DIHYDROXYVITAMIN D METABOLITES BY MASS SPECTROMETRY - Provided are methods of detecting the presence or amount of a dihydroxyvitamin D metabolite in a sample using mass spectrometry. The methods generally comprise ionizing a dihydrorxyvitamin D metabolite in a sample and detecting the amount of the ion to determine the presence or amount of the vitamin D metabolite in the sample. In certain preferred embodiments the methods include immunopurifying the dihydroxyvitamin D metabolites prior to mass spectrometry. Also provided are methods to detect the presence or amount of two or more dihydroxyvitamin D metabolites in a single assay. | 03-15-2012 |
20120085902 | METHODS FOR DETECTING VITAMIN D METABOLITES BY MASS SPECTROMETRY - Provided are methods of detecting the presence or amount of a vitamin D metabolite in a sample using mass spectrometry. The methods generally comprise ionizing a vitamin D metabolite in a sample and detecting the amount of the ion to determine the presence or amount of the vitamin D metabolite in the sample. Also provided are methods to detect the presence or amount of two or more vitamin D metabolites in a single assay. | 04-12-2012 |
20120115242 | VITAMIN D METABOLITE DETERMINATION UTILIZING MASS SPECTROMETRY FOLLOWING DERIVATIZATION - The invention relates to the detection of vitamin D metabolites. In a particular aspect, the invention relates to methods for detecting derivatized vitamin D metabolites by mass spectrometry. | 05-10-2012 |
20120164741 | QUANTITATION OF INSULIN BY MASS SPECTROMETRY - Methods are described for determining the amount of insulin in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying insulin in a biological sample utilizing purification methods coupled with tandem mass spectrometric or high resolution/high accuracy mass spectrometric techniques. | 06-28-2012 |
20130137185 | MASS SPECTROMETRY OF STEROIDAL COMPOUNDS IN MULTIPLEXED PATIENT SAMPLES - The invention relates to the quantitative measurement of steroidal compounds by mass spectrometry. In a particular aspect, the invention relates to methods for quantitative measurement of steroidal compounds from multiple samples by mass spectrometry. | 05-30-2013 |
20150323513 | QUANTITATION OF TAMOXIFEN AND METABOLITES THEREOF BY MASS SPECTROMETRY - Provided are methods for determining the amount of tamoxifen and its metabolites in a sample by mass spectrometry. In some aspects, the methods provided herein comprise determining the amount of norendoxifen. In some aspects, the methods provided herein comprise determining the amount of norendoxifen and tamoxifen. In some aspects, the methods provided herein comprise determining the amount of norendoxifen and other tamoxifen metabolites. In some aspects, the methods provided herein comprise determining the amount of tamoxifen, norendoxifen, and other tamoxifen metabolites. | 11-12-2015 |
20160061848 | MASS SPECTROMETRY OF STEROIDAL COMPOUNDS IN MULTIPLEXED PATIENT SAMPLES - The invention relates to the quantitative measurement of steroidal compounds by mass spectrometry. In a particular aspect, the invention relates to methods for quantitative measurement of steroidal compounds from multiple samples by mass spectrometry. | 03-03-2016 |
Patent application number | Description | Published |
20080299266 | Containers - Respiring biological materials can be stored in a sealed container having (i) an interior surface at least partly composed of a hydrophilic polymer composition and (ii) an auxiliary component through which oxygen and carbon dioxide can enter or leave the packaging atmosphere within the container. | 12-04-2008 |
20090104317 | Combinations of Atmosphere Control Members - Combinations of atmosphere control members are used to control the atmosphere within a sealed container which contains a respiring biological material. The combination makes use of a first ACM having a first R ratio (the ratio of carbon dioxide permeability to oxygen permeability) and a second ACM having a second R ratio, the first R ratio being substantially greater than 1.0, and the second R ratio being less than the first R ratio. This combination ( | 04-23-2009 |
20090324782 | Packaging of Respiring Biological Materials - Packaging of respiring biological materials, particularly bananas and other fruits, in sealed containers. The containers preferably include a gas-permeable membrane comprising (1) a microporous film, and (2) a polymeric coating on the microporous film. Using appropriate containers and appropriate controlled atmospheres around the container, the respiring materials can be stored and/or ripened under controlled conditions. Bananas can be ripened while they are being transported, or in conventional ripening rooms without opening the containers in which they have been transported. The ripe bananas are less dehydrated and remain in a satisfactory ripened state for longer periods of time. | 12-31-2009 |
20120135114 | PACKAGING OF RESPIRING BIOLOGICAL MATERIALS - Packaging of bananas in containers, for example polyethylene bags, having designed permeabilities to oxygen, carbon dioxide, and ethylene. The bags preferably include a gas-permeable membrane comprising (1) a microporous film, and (2) a polymeric coating on the microporous film. The containers enable storage and/or ripening of bananas under controlled conditions. Using the new containers, bananas can be ripened while they are being transported, or in conventional ripening rooms without opening the containers in which they have been transported, or after they have left a ripening room. In addition, bananas can be preserved in a satisfactory ripened state for longer periods of time. | 05-31-2012 |
20140030391 | Atmosphere Control Around Respiring Biological Materials - Packaging of respiring biological materials, particularly bananas and other fruits, in sealed containers. The containers preferably include a gas-permeable membrane comprising (1) a microporous film, and (2) a polymeric coating on the microporous film. Using appropriate containers and appropriate controlled atmospheres around the container, the respiring materials can be stored and/or ripened under controlled conditions. Bananas can be ripened while they are being transported, or in conventional ripening rooms without opening the containers in which they have been transported. The ripe bananas are less dehydrated and remain in a satisfactory ripened state for longer periods of time. The gas-permeable membrane can preferably take the form of either a “curtain” or “cartridge” and the R ratio of the membrane may be optimized by adjusting the differential pressure across the membrane. | 01-30-2014 |
20140377416 | Packaging and Methods of Use For Respiring Biological Materials - Packaging of fruits in containers. The containers preferably have designed permeabilities to oxygen, carbon dioxide, and ethylene and include a gas-permeable membrane comprising (1) a microporous film, and (2) a polymeric coating on the microporous film. The containers enable storage and/or ripening of fruits under controlled conditions. Using the new containers, fruits can be ripened while they are being transported, or in conventional ripening rooms without opening the bags in which they have been transported. In addition, fruits can be preserved in a satisfactory ripened state for longer periods of time. Methods of treating fruits with insecticides, fungicides and mold-inhibiting compounds are also disclosed. | 12-25-2014 |
Patent application number | Description | Published |
20080233484 | Battery with Gelled Electrolyte - An electric device comprises a gelled acid electrolyte in complex with a lanthanide that forms a redox pair with a second element. Preferred electric devices include batteries, and especially primary batteries, while preferred acid electrolytes have a sulfonic acid group. Contemplated lanthanides especially include cerium, and preferred second elements particularly include zinc. Alternatively, contemplated electric devices may comprise a gelled electrolyte in which with a lanthanide forms a redox pair with zinc. | 09-25-2008 |
20090008333 | Perchlorate Destruction - Perchlorate is removed and effectively destroyed in devices and methods that employ a eluting solvent in which the anion of an acid solubilizes Ti (III), which may be electrochemically generated or added in situ. Using such solvents, destruction of perchlorate is unexpectedly and several orders of magnitude faster than using solvents without solubilizing acids. In most preferred aspects, the solubilizing acid is methane sulfonic acid and/or sulfamic acid, and Ti (III) is electrochemically generated. Perchlorate destruction will then result in formation of Ti (IV), which may be present in the eluent in a subsequent elution. | 01-08-2009 |
20090014337 | Electrochemical Nitrate Destruction - Devices and methods are presented for removal and destruction of nitrate from water using an ion exchange medium from which the nitrate is eluted using brine, and in which the so generated eluent is sequentially reduced and oxidized in distinct compartments to form nitrogen from nitrate and ammonia, respectively. In especially preferred devices and methods, the reduced and oxidized eluent is re-reduced to electrochemically destroy hypohalites formed during oxidation. Among other advantages, contemplated devices and methods allow nitrate destruction with minimal concomitant production of nitrite and hypohalites. | 01-15-2009 |
20090152123 | Methods and Apparatus for Generating Oxidizing Agents - Contemplated devices and methods include an electrolytic cell having a cathode and a carbon felt anode, wherein the carbon felt anode is configured as a flow-through anode for an aqueous solution in which a contaminant is dissolved or dispersed. The cell is operated at a current density that promotes formation of oxidizing species in neutral pH to thus destroy the contaminant and at a flow rate sufficient to prevent oxidative damage of the carbon felt. | 06-18-2009 |
20090159459 | Electrochemical Recovery of Arsenic - Contemplated devices and methods for arsenic recovery employ a two-step process in which an arsenite and arsenate-containing solution is first subjected to a non-electrochemical reduction that reduces arsenate and arsenite. The arsenate-depleted arsenite-containing solution is the subjected to electrochemical reduction at alkaline pH using a cathode with a high-surface carbon portion. Most preferably, the treated solution is then used as eluent for an adsorbent that removed arsenate and arsenite from a water supply. | 06-25-2009 |
20100059388 | Electrochemical Oxidation of Organic Matter - Carbonaceous feedstock is at least partially oxidized using a concentrated metal ion solution that is regenerated in an electrochemical hydrogen gas producing process. The at least partially oxidized feedstock and/or hydrogen are then advantageously used as an energy carrier in a downstream process. | 03-11-2010 |
20110305927 | Devices and Methods for Lead Acid Batteries - A bipolar lead acid battery comprises a compression resistant separator in which the electrolyte is retained in a gelled form, and wherein quasi-bipolar electrodes are maintained in a cell stack under pressure. Most preferably, the negative active material further includes a compression resistant spacer structure and the battery is configured as a VR-BLAB where each single cell can independently vent gases during the charge cycle. | 12-15-2011 |
Patent application number | Description | Published |
20100048419 | Combinatorial Screening Method and Apparatus - A combinatorial screening method and system are provided. The combinatorial system and method provide rapid data generation for characterization of phase change material. The characterization data is collected through a multipoint probe card where multiple regions are characterized in a single annealing cycle. | 02-25-2010 |
20120119768 | Method and System of Improved Reliability Testing - A method and system of improved reliability testing includes providing a first substrate and a second substrate, each substrate comprising only a first metallization layer; processing regions on a first substrate by combinatorially varying at least one of materials, unit processes, and process sequences; performing a first reliability test on the processed regions on the first substrate to generate first results; processing regions on a second substrate in a combinatorial manner by varying at least one of materials, unit processes, and process sequences based on the first results of the first reliability test; performing a second reliability test on the processed regions on the second substrate to generate second results; and determining whether the first substrate and the second substrate meet a predetermined quality threshold based on the second results. | 05-17-2012 |
20120290245 | METHOD AND APPARATUS FOR PARALLEL TESTING OF SEMICONDUCTOR DEVICES - Method and apparatus for parallel testing of multiple regions on a substrate used in high performance combinatorial development of new materials and processes are described. The apparatus comprises dedicated hardware for each probe assembly with multiple PC controllers networked using a master/slave configuration. | 11-15-2012 |
20120293162 | METHOD FOR TESTING MULTIPLE COUPONS - A method for testing multiple coupons is described. The x, y, and theta offset coordinates of a reference structure for each coupon are determined. Additionally, the x and y offset coordinates between the reference structure and the first test device are determined. After the reference data from all of the coupons have been determined, the testing sequence for all of the coupons can be initiated and completed without further intervention. | 11-22-2012 |
20130228735 | INTERFACIAL OXIDE USED AS SWITCHING LAYER IN A NONVOLATILE RESISTIVE MEMORY ELEMENT - A nonvolatile resistive memory element includes a host oxide formed from an interfacial oxide layer. The interfacial oxide layer is formed on the surface of a deposited electrode layer via in situ or post-deposition surface oxidation treatments. The switching performance of a resistive memory device based on such an interfacial oxide layer is equivalent or superior to the performance of a conventional resistive memory element. | 09-05-2013 |
Patent application number | Description | Published |
20140192585 | Resistive Random Access Memory Cell Having Three or More Resistive States - Provided are resistive random access memory (ReRAM) cells, each having three or more resistive states and being capable of storing multiple bits of data, as well as methods of fabricating and operating such ReRAM cells. Such ReRAM cells or, more specifically, their resistive switching layer have wide range of resistive states and are capable of being very conductive (e.g., about 1 kOhm) in one state and very resistive (e.g., about 1 MOhm) in another state. In some embodiments, a resistance ratio between resistive states may be between 10 and 1,000 even up to 10,000. The resistive switching layers also allow establishing stable and distinct intermediate resistive states that may be assigned different data values. These layers may be configured to switching between their resistive states using fewer programming pulses than conventional systems by using specific materials, switching pluses, and resistive state threshold. | 07-10-2014 |
20150311257 | Resistive Random Access Memory Cells Having Shared Electrodes with Transistor Devices - Provided are resistive random access memory (ReRAM) cells having extended conductive layers operable as electrodes of other devices, and methods of fabricating such cells and other devices. A conductive layer of a ReRAM cell extends beyond the cell boundary defined by the variable resistance layer. The extended portion may be used a source or drain region of a FET that may control an electrical current through the cell or other devices. The extended conductive layer may be also operable as electrode of another resistive-switching cell or a different device. The extended conductive layer may be formed from doped silicon. The variable resistance layer of the ReRAM cell may be positioned on the same level as a gate dielectric layer of the FET. The variable resistance layer and the gate dielectric layer may have the same thickness and share common materials, though they may be differently doped. | 10-29-2015 |
Patent application number | Description | Published |
20100304152 | FIRE RESISTANT FLEXIBLE CERAMIC RESIN BLEND AND COMPOSITE PRODUCTS FORMED THEREFROM - High heat resistant elastic composite laminates, sealants, adhesives, and coatings developed from a resin blend. The resin blend is made up of methyl and optionally phenyl silsequioxane resins selected to produce silanol-silanol condensation silicone polymers formed in a slowly evolving reaction mass containing submicron boron nitride, silica and boron oxide fillers. The required ratio of submicron boron nitride to silica has been discovered for assuring the formation of a high temperature resistant elastic composite blend that will form intermediate flexible ceramic products up to 600 deg C., then continue to form preceramic then dense ceramic products from 600 to 1000 deg C. The thermal yield of the composite is generally greater than 90 wt. % at 1000 deg C. Composite products with different levels of heat transformation can be fabricated within the same product depending upon the thickness of the layers of reinforcement. | 12-02-2010 |
20100319656 | Internal Combustion (IC) Engine Head Assembly Combustion Chamber Multiple Spark Ignition (MSI) Fuel Savings Device and Methods of Fabrication Thereof - This invention describes how a blend of silicon polymers, mixed with the right combination of fillers applied to fiber reinforcement laminated with an embedded circuit and laser cut into vacuum formable preforms enables the production of “red heat” durable flexible ceramic multiple spark ignition devices which are vacuum formed into the head combustion chamber of IC engines for realizing fuel savings from up to 33% increased combustion efficiency. The MSI device also comprises a spark plug which is made with the steel adjustable grounding gap section removed. The spark plug electrode alignment for the fuel injectors is also used to align the spark plug electrode to insert during assembly into the MSI device (see FIG. | 12-23-2010 |
20100320700 | Red Heat Exhaust System Silicone Composite O-Ring Gaskets and Method for Fabricating Same - This invention extends the elastic range of silicone composite gaskets from typically −40 to 300° C. (Reference I) to temperatures within the “red heat”, Le, 600 to 1000° C. applications The composite gaskets comprise a matrix of cured methyl and/or phenyl-silsesquioxane resins, boron oxide, boron oxide and silica additives and a reinforcing material that enables highly thermally stable elastic composites to be fabricated into durable composite exhaust system gaskets The invention offers the most economical and proven durable solution to the current high temperature sealing problems (Reference 2) and cost of current traditional multi-layer steel gaskets The method for making the composite gaskets comprises applying the above resin blend to continuous or discontinuous fiber reinforcing material and curing the resin | 12-23-2010 |
20100324187 | Silicone Resin Composites for High Temperature Durable Elastic Composite Applications and Methods for Fabricating Same - This invention relates to composites for use in high temperature elastic composite applications. Most particularly, this invention relates to elastic composites formed with a silanol-silanol condensation reaction mixture of silsesquioxane silicone resins thermally stabilized by boron nitride, silica and boron oxide additives as their matrix. The polymer matrix composite comprise a matrix of cured high, intermediate and optionally low molecular weight silicone resins including boron nitride and silica additives and reinforcing material. | 12-23-2010 |