Harrington, OH
Edward R. Harrington, Toledo, OH US
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20090000515 | Process of producing roofing shingle coating asphalt - A process of producing a roofing shingle coating asphalt from an asphalt feedstock includes the following steps. Wax and blowing catalyst are added to the asphalt feedstock. Then the asphalt feedstock is blown to produce the coating asphalt. The coating asphalt has a softening point within a range of from about 190° F. (88° C.) to about 235° F. (113° C.) and has a penetration of at least about 15 dmm at 77° F. (25° C.). | 01-01-2009 |
20090004387 | Process of producing roofing shingle coating asphalt allowing more material options - In a process of producing a roofing shingle coating asphalt from a low flashpoint asphalt feedstock, an asphalt feedstock which has a low flashpoint of from 490° F. (254° C.) to 540° F. (282° C.) is partially blown, and wax is added to the asphalt feedstock. The process produces a coating asphalt having a low melt viscosity of from 50 cps to 150 cps at 400° F. (204° C.), a softening point of from 190° F. (88° C.) to 235° F. (113° C.) and a penetration of at least 15 dmm at 77° F. (25° C.). In another embodiment, the process produces a roofing shingle coating asphalt having good weatherability from a poor weathering asphalt feedstock. In a further embodiment, the process produces roofing shingles including a filled coating containing a poor tear filler without sacrificing the tear strength of the shingles. | 01-01-2009 |
John Harrington, Cleveland, OH US
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20140194411 | BENZAZEPINES AS SEROTONIN 5-HT2C RECEPTOR LIGANDS AND USES THEREOF - The present invention generally relates to a series of compounds, to pharmaceutical compositions containing the compounds, and to use of the compounds and compositions as therapeutic agents. More specifically, compounds of the present invention are benzazepine compounds. These compounds are serotonin receptor (5-HT | 07-10-2014 |
20140275035 | THIENYLINDOLE AZEPINES AS SEROTONIN 5-HT2C RECEPTOR LIGANDS AND USES THEREOF - The present invention generally relates to a series of compounds, to pharmaceutical compositions containing the compounds, and to use of the compounds and compositions as therapeutic agents. More specifically, compounds of the present invention are thienylindole azepines. These compounds are serotonin receptor (5-HT | 09-18-2014 |
John J. Harrington, Mentor, OH US
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20090285801 | Calcium-Sensing Receptor 2 (CaR2) and Methods for Using - The current disclosure provide a novel human calcium sensing receptor named CaR2 and the nucleotide sequence that encodes the receptor. The disclosure further provides antibodies specific for CaR2. Also disclosed are methods of identifying modulators of the receptor and methods of using the identified modulators to treat calcium receptor mediated conditions. | 11-19-2009 |
20110217779 | Compositions and Methods for Non-Targeted Activation of Endogenous Genes - The present invention is directed generally to activating gene expression or causing over-expression of a gene by non-homologous or illegitimate recombination, of a regulatory sequence that causes expression of the gene. Thus, by the present invention, endogenous genes, including those associated with human disease and development, may be activated and isolated without prior knowledge of the sequence, structure, function, or expression profile of the genes. | 09-08-2011 |
John Joseph Harrington, Mentor, OH US
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20100010196 | COMPOSITIONS AND METHODS FOR NON-TARGETED ACTIVATION OF ENDOGENOUS GENES - The present invention is directed generally to activating gene expression or causing over-expression of a gene by recombination methods in situ. The invention also is directed generally to methods for expressing an endogenous gene in a cell at levels higher than those normally found in the cell. In one embodiment of the invention, expression of an endogenous gene is activated or increased following integration into the cell, by non-homologous or illegitimate recombination, of a regulatory sequence that activates expression of the gene. In another embodiment, the expression of the endogenous gene may be further increased by co-integration of one or more amplifiable markers, and selecting for increased copies of the one or more amplifiable markers located on the integrated vector. In another embodiment, the invention is directed to activation of endogenous genes by nontargeted integration of specialized activation vectors, which are provided by the invention, into the genome of a host cell. The invention also provides methods for the identification, activation, isolation, and/or expression of genes undiscoverable by current methods since no target sequence is necessary for integration. The invention also provides methods for isolation of nucleic acid molecules (particularly cDNA molecules) encoding a variety of proteins, including transmembrane proteins, and for isolation of cells expressing such transmembrane proteins which may be heterologous transmembrane proteins. The invention also is directed to isolated genes, gene products, nucleic acid molecules, to compositions comprising such genes, gene products and nucleic acid molecules, and to vectors and host cells comprising such genes and nucleic acid molecules, that may be used in a variety of therapeutic and diagnostic applications. Thus, by the present invention, endogenous genes, including those associated with human disease and development, may be activated and isolated without prior knowledge of the sequence, structure, function, or expression profile of the genes. | 01-14-2010 |
20100311612 | Compositions and Methods for Making Mutations in Cell Lines and Animals - The present invention is directed generally to reduction or inactivation of gene function or gene expression in cells in vitro and in multicellular organisms. The invention encompasses methods for mutating cells using a combination of mutagens, particularly wherein at least one mutagen is an insertional mutagen, to achieve homozygous gene mutation or mutation of multiple genes required cumulatively to achieve a phenotype to create knock-outs, knock-downs, and other modifications in the same cell. The invention is also directed to cells (and libraries thereof) and organisms created by the methods of the invention, including those in which at least one of the genes created by insertional mutagenesis is tagged by means of the insertion sequences thereby allowing identification of the mutated gene(s). The invention is also directed to libraries of mutated cells and their uses. The invention is also directed to methods of identifying mutations with methods of the invention, in cells (and libraries thereof) and organisms, by means of the insertional tag. | 12-09-2010 |
Mark Harrington, Cincinnati, OH US
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20110076158 | METHOD OF OPERATING ADAPTIVE CORE ENGINES - A method of operating a compressor in an adaptive core engine is disclosed. The method comprises the steps of operating a front block compressor to increase pressure of a fluid to a first pressure ratio in a high-power mode operation; operating a rear block compressor coupled to the front block compressor such that the front block compressor and the rear block compressor operate at the same physical speed; closing a rear block stator vane located axially forward from the rear block compressor such that the flow of the fluid into the rear block compressor is substantially cut off; and keeping a blocker door opened such that substantially all of the fluid pressurized by the front block compressor flows through a bypass passage during the high-power mode operation. The operation may be transitioned from the high-power mode to a low-power mode by opening a rear block stator such that the rear block compressor receives at least a portion of the fluid flowing from the front block compressor and maintains an overall engine pressure ratio. | 03-31-2011 |
Nicholas R. Harrington, Mason, OH US
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20120328150 | METHODS FOR ASSISTING WITH OBJECT RECOGNITION IN IMAGE SEQUENCES AND DEVICES THEREOF - A method, non-transitory computer readable medium, and apparatus that assist with object recognition includes determining when at least one eye of an observer fixates on a location in one or more of a sequence of fixation tracking images. The determined fixation location in the one or more of the sequence of fixation tracking images is correlated to a corresponding one of one or more sequence of field of view images. At least the determined fixation location in each of the correlated sequence of field of view images is classified based on at least one of a classification input or a measurement and comparison of one or more features of the determined fixation location in each of the correlated sequence of field of view images against one or more stored measurement feature values. The determined classification of the fixation location in each of the correlated sequence of field of view images is output. | 12-27-2012 |
Nick Robert Harrington, West Chester, OH US
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20100174586 | Methods for Measuring Emotive Response and Selection Preference - The present invention relates generally to consumer research methods for measuring emotive response to visual stimuli. | 07-08-2010 |
Richard D. Harrington, Cincinnati, OH US
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20090084924 | DOCUMENT HOLDER FOR CARTS - A document holder is provided for a vehicle such as a cart, and especially a shopping cart having a back panel. The document holder includes a writing portion and a bracket portion. A securing member is provided at the writing portion to secure a piece of paper such as a grocery list or coupons. Preferably, the bracket portion has a forward bracket member spaced from a rearward bracket member to define a channel for receiving an upper portion of the back panel to support the holder. The securing member may be configured to hold a writing instrument. An advertisement holder may be positioned on the holder to hold and protect advertisements, store announcements, pictures, or the like while also providing a writing surface thereon. In a preferred embodiment, a document holder includes a flexible, resilient frame or bumper, and/or a two-piece bracket portion for attachment to a shopping cart. | 04-02-2009 |
Richard M. Harrington, Cincinnati, OH US
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20090008058 | CASTING MATERIALS - A foam material comprises a liquid polymer and a liquid isocyanate which is mixed to make a solution that is poured, injected or otherwise deposited into a corresponding mold. A reaction from the mixture of the liquid polymer and liquid isocyanate inside the mold forms a thermally collapsible foam structure having a shape that corresponds to the inside surface configuration of the mold and a skin that is continuous and unbroken. Once the reaction is complete, the foam pattern is removed from the mold and may be used as a pattern in any number of conventional casting processes. | 01-08-2009 |
20090065469 | Bottle Handling Device - A bottle handling device comprises a cup, a base, a support wall, a handle support member, and a clip. The base extends from the bottom of the cup and the support wall extends upward from the cup. The handle is integral with the support wall at a lower end and is integral with the clip at an upper end. An alternate embodiment comprises a cup, a handle and a clip. A fixed portion of the handle is integral with the cup, while a free portion of the handle is integral with the clip that extends over the cup. Another embodiment comprises a cup, a clip, and a handle and transitions from a first configuration toward a second configuration. The handle is connected to the clip and cup with hinges. The clip and cup comprise at least one locking member configured to lock the device into the second configuration. | 03-12-2009 |
20120007266 | FOAM PATTERNS - A method of creating a foam pattern comprises mixing a polyol component and an isocyanate component to form a liquid mixture. The method further comprises placing a temporary core having a shape corresponding to a desired internal feature in a cavity of a mold and inserting the mixture into the cavity of the mold so that the mixture surrounds a portion of the temporary core. The method optionally further comprises using supporting pins made of foam to support the core in the mold cavity, with such pins becoming integral part of the pattern material simplifying subsequent processing. The method further comprises waiting for a predetermined time sufficient for a reaction from the mixture to form a foam pattern structure corresponding to the cavity of the mold, wherein the foam pattern structure encloses a portion of the temporary core and removing the temporary core from the pattern independent of chemical leaching. | 01-12-2012 |
20130174996 | FOAM PATTERN TECHNIQUES - Various techniques are provided for creating fugitive foam patterns for use in investment casting operations. In certain illustrative embodiments, a fugitive foam pattern is assembled from independently formed portions. A first section is formed in a mold. Once cured, a mating surface of the first section is exposed to the cavity of a second mold and the section is formed. The second section integrally adheres to the first section. The process is repeated as necessary. In alternative embodiments, a channel is created in a foam pattern using a temporary core that is removed without chemical leaching. The core material comprises water-soluble materials, acid-soluble materials, low-melting point materials, or a combination thereof. A pattern may also be created by inserting foam around a core that remains with the foam pattern. | 07-11-2013 |
Roy Jerome Harrington, Liberty Township, OH US
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20090258810 | GEL AUTOMATIC DISHWASHING DETERGENT COMPOSITION - A detergent composition having a desired rheology formulated from a thickener system of xanthan gum and either an associative thickener or a soluble silicate; one or more enzymes; an enzyme stabilizer; and water having a pH from 7.0 to 10. | 10-15-2009 |
20100105597 | METHODS FOR MAKING A NIL-PHOSPHATE LIQUID AUTOMATIC DISHWASHING COMPOSITION - A method of making a liquid ADW detergent composition comprising the successive steps of: a) forming a solution premix comprising: i) water; ii) an alkali metal carbonate; iii) a dispersant polymer; and b) adding an alkali metal silicate to said solution premix wherein said composition comprises a low-foaming nonionic surfactant and wherein said composition is substantially free of a phosphate builder. | 04-29-2010 |
20140020188 | COMPOSITIONS COMPRISING HYDROPHOBICALLY MODIFIED CATIONIC POLYMERS - This invention relates to compositions comprising hydrophobically modified cationic polymers as well as processes of making and using such compositions. Such hydrophobically modified cationic polymers may be added to the composition in a variety of ways including, but not limited to, as a component of a particle. Advantages of such compositions include the ability to selectively increase the deposition of benefit agents without effectively increasing deposition of undesired materials. | 01-23-2014 |
20150030557 | BENEFIT AGENT EMULSIONS AND CONSUMER PRODUCTS CONTAINING SUCH EMULSIONS - Consumer product compositions providing enhanced hydrophobic benefit agent deposition. The benefit agent is provided as a benefit agent/deposition aid emulsion, where the benefit agent is physically adsorbed to the deposition aid before the emulsion is added to the balance of ingredients. | 01-29-2015 |
Roy Jerome Harrington, Hamilton, OH US
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20140024780 | Hydrophobically Modified Cationic Polymer - The present invention relates to hydrophobically modified cationic polymers obtainable by the polymerization of one or more cationic ethylenically unsaturated monomers with an ethylenically unsaturated monomer having anhydride, imide, lactone, carboxylic acid, isocyanate or blocked isocyanate group and a reactive siloxane and processes for preparing them. These polymers are useful i.a. as a depositioning aid of hydrophobic actives onto fibrous substrates. | 01-23-2014 |
Stephanie Adi Soulen Harrington, Mentor, OH US
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20110160776 | APPARATUS AND METHOD FOR BODY TISSUE FIXATION - A body tissue fixation apparatus includes a plate having oppositely disposed outer and tissue-contacting surfaces, and at least one fixation hole extending between the outer and tissue-contacting surfaces along a longitudinal axis. The fixation hole is defined in part by an inner hole surface having at least one serration. The plate is adapted for affixation to at least one body tissue member. At least one fixation device of the body tissue fixation apparatus has a shank and a head portion, the shank being insertable through the fixation hole in the plate to affix the plate to the body tissue member upon rotation of the head portion. At least one deformable member is connected to the head portion, the deformable member extending laterally in a direction substantially perpendicular to the longitudinal axis and being adapted to deflect to engage with at least one serration formed on the inner hole surface. Engagement between the deformable member and the serration helps to prevent displacement of the fixation device within the fixation hole. A method for using the body tissue fixation apparatus is also described. | 06-30-2011 |
Stephanie A.s. Harrington, Mentor, OH US
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20080242930 | SECURABLE CANNULA AND METHOD - A medical device suitable for introducing a medical instrument into a patient includes an outer cannula and at least one arm connected to the cannula toward a proximal portion of the at least one arm. The at least one arm is deployable between a closed position and an open position. An inner member is telescopically received in the outer cannula to hold each arm in the closed position. The inner member is deployable to disengage from the arm after the device is inserted into a patient, thereby freeing the arm to be deployed to the open position where it helps hold the outer cannula in the patient. The inner member includes an inner cannula and/or a trocar. | 10-02-2008 |
20100130972 | ELECTRICAL SKIN TREATMENT DEVICE AND METHOD - An electrical device for treating problem skin areas, including warts, has an electrode and a power source coupled to the electrode for generating an arc over a gap between a distal end of the electrode and a patient's skin when the electrode is placed in spaced proximity to the patient's skin. The power source provides electricity to the electrode with a frequency of at least 100 kHz, an open-circuit voltage of less than 2 kV | 05-27-2010 |
20110196397 | MEDICAL DEVICE WITH A GUIDEWIRE FOR PENETRATING OCCLUSIONS - A medical device includes an outer catheter having a longitudinal axis, a movable device that can pass through the catheter and is movable along the longitudinal axis relative to the catheter, and a magnetic drive engine toward a distal end of the catheter. The magnetic drive engine includes at least two components with respective magnetic field-generating coils and magnets, that move relative to one another. One of the two components is coupled to the movable device for driving vibratory motion in the movable device along the longitudinal axis. An exemplary movable device is a guidewire over which the catheter is fed. The device typically includes a second catheter threaded inside the first catheter. The first or outer catheter shields the magnetic engine and its moving components. | 08-11-2011 |