Patent application number | Description | Published |
20100008989 | PROCESS FOR MANUFACTURE OF GELATIN SOLUTIONS AND PRODUCTS THEREOF - A process for the preparation of gelatin solutions which is less than a physiologically relevant temperature, which is preferably less than about 37° C., the process comprising adding one or more transition point reducing agents, such as hydrogen bond breakers, reducing agents, plasticizers, surfactants, metal ions or denaturants (denaturing agents), to the gelatin solution. The reduced temperature processing can reduce damage to thermo sensitive pharmaceuticals ingredients or vitamins, or other heat sensitive ingredients. | 01-14-2010 |
20110086014 | METHOD FOR ENZYMATIC CROSS-LINKING OF A PROTEIN - A method for cross-linking albumin for use as a sealant or glue for a biological system, for example to induce hemostasis and/or prevent leakage of any other fluid from a biological tube or tissue, such as lymph for example. The cross-linked albumin may optionally and preferably be applied as part of a bandage for example. In other embodiments, the present invention provides a method of enzymatically cross-linking globular proteins, by altering the structure of the protein to improve the accessibility of the protein to the cross-linking enzyme. | 04-14-2011 |
20110110882 | CROSS-LINKED COMPOSITIONS - Improved compositions comprising a cross-linkable protein or polypeptide, and a non-toxic material which induces cross-linking of the cross-linkable protein. The compositions are optionally and preferably prepared in a non-phosphate buffer solvent. Optionally and preferably, the cross-linkable protein includes gelatin and any gelatin variant or variant protein as described herein. Optionally and preferably, the non-toxic material comprises transglutaminase (TG), which may optionally comprise any type of calcium dependent or independent transglutaminase, which may for example optionally be a microbial transglutaminase (mTG). | 05-12-2011 |
20110112573 | METHODS AND DEVICES FOR USE WITH SEALANTS - A biocompatible medical sealant for use in a biological system, the sealant comprising a solution of a cross-linkable protein or polypeptide and a solution of a non-toxic cross-linking material which induces cross-linking of said cross-linkable protein, thereby sealing at least a portion of the biological system. | 05-12-2011 |
20120226211 | Gelatin-Transglutaminase Hemostatic Dressings and Sealants - An adhesive material for medical use comprising gelatin and a non-toxic cross-linking material such as transglutaminase. An optional embodiment of the invention includes dressings in which a layer of a transglutaminase is sandwiched between a first and second layer of gelatin. The hemostatic products are useful for the treatment of wounded tissue. | 09-06-2012 |
20120270810 | MODIFICATION OF ENZYMATIC CROSSLINKERS FOR CONTROLLING PROPERTIES OF CROSSLINKED MATRICES - Improved matrix or hydrogel that is formed by enzymatic crosslinking of polymers wherein the crosslinking enzyme molecules have been modified for the purpose of improving the crosslinking density, mechanical properties, or other properties of the matrix, and/or to provide improved control over the rate and/or extent of crosslinking, wherein the enzyme molecules are modified to alter the perceived volume of the enzyme molecules in the crosslinked matrix being formed. Methods of production and of use are also provided. | 10-25-2012 |
20120329132 | CROSS-LINKED COMPOSITIONS - Improved compositions comprising a cross-linkable protein or polypeptide, and a non-toxic material which induces cross-linking of the cross-linkable protein. The compositions are optionally and preferably prepared in a non-phosphate buffer solvent. Optionally and preferably, the cross-linkable protein includes gelatin and any gelatin variant or variant protein as described herein. Optionally and preferably, the non-toxic material comprises transglutaminase (TG), which may optionally comprise any type of calcium dependent or independent transglutaminase, which may for example optionally be a microbial transglutaminase (mTG). | 12-27-2012 |
20130039899 | METHODS AND DEVICES FOR APPLYING TISSUE SEALANTS AND ADHESIVES - Methods of application and devices thereof for tissue adhesives. The adhesives comprise a plurality of components which are provided separately but which are mixed together to form the adhesive. At least one component is a crosslinkable protein solution and at least one other component is a crosslinking material solution. The devices preferably include a mixing unit, which may include dynamic mixing elements, static mixing elements, or a combination of the two. | 02-14-2013 |
20130131701 | DRY COMPOSITION WOUND DRESSINGS AND ADHESIVES - Patches comprising dry gelatin compositions and methods of use and manufacture thereof. | 05-23-2013 |
20140193386 | METHOD FOR ENZYMATIC CROSS-LINKING OF A PROTEIN - A method for cross-linking albumin for use as a sealant or glue for a biological system, for example to induce hemostasis and/or prevent leakage of any other fluid from a biological tube or tissue, such as lymph for example. The cross-linked albumin may optionally and preferably be applied as part of a bandage for example. In other embodiments, the present invention provides a method of enzymatically cross-linking globular proteins, by altering the structure of the protein to improve the accessibility of the protein to the cross-linking enzyme. | 07-10-2014 |
20140314732 | CROSS-LINKED COMPOSITIONS - Improved compositions comprising a cross-linkable protein or polypeptide, and a non-toxic material which induces cross-linking of the cross-linkable protein. The compositions are optionally and preferably prepared in a non-phosphate buffer solvent. Optionally and preferably, the cross-linkable protein includes gelatin and any gelatin variant or variant protein as described herein. Optionally and preferably, the non-toxic material comprises transglutaminase (TG), which may optionally comprise any type of calcium dependent or independent transglutaminase, which may for example optionally be a microbial transglutaminase (mTG). | 10-23-2014 |