Patent application number | Description | Published |
20080246344 | ARRANGEMENT FOR FAILSAFE EVALUATION OF A POSITION ENCODER - A safety switching device comprises a position encoder, such as a potentiometer, for user selection of an operational quantity, such as an operating mode. The position encoder has a first terminal, a second terminal, and a tap moveable through a plurality of positions. A total impedance is defined between the first terminal and the second terminal. A first partial impedance is defined between the first terminal and the tap, and a second partial impedance is defined between the tap and the second terminal. An arrangement for determining an instantaneous position of the tap comprises a first evaluation circuit designed to determine a first measurement value representative of the first partial impedance, and a second evaluation circuit designed to determine a second measurement value representative of the second partial impedance. At least one from the first and second evaluation circuits is designed to determine the instantaneous position of the tap by means of the first and second measurement values. | 10-09-2008 |
20080278875 | Safety switching apparatus for a failsafe disconnection of an electrical load - A safety switching apparatus for failsafe disconnection of an electrical load has a first and a second connecting terminal for connecting a first signaling switch and a third and a fourth connecting terminal for connecting a second signaling switch. It also has a first and a second output switching element, which are designed to produce a redundant output switching signal. The first connecting terminal is connected to a first potential and the third connecting terminal is connected to a second potential. The potentials differ from one another. In addition, the second connecting terminal is coupled to the first switching element in such a way that the first switching element receives the first potential via the first signaling switch. Likewise, the fourth connecting terminal is coupled to the second switching element in such a way that the second switching element receives the second potential via the second signaling switch. According to one aspect of the invention, a circuit arrangement is provided for determining at least one further potential at the second and/or fourth connecting terminal, and said circuit arrangement is designed to control the redundant output switching signal as a function of the further potential. | 11-13-2008 |
Patent application number | Description | Published |
20090283470 | Plasma Separation Membrane - A process for manufacturing of an asymmetric hollow fibre membrane, comprising the steps of extruding a polymer solution through the outer ring slit of a hollow fibre spinning nozzle, simultaneously extruding a centre fluid through the inner bore of the hollow fibre spinning nozzle, into a precipitation bath, whereby the polymer solution contains 10 to 26 wt-% of polysulfone (PSU), polyethersulfone (PES) or polyarylethersulfone (PAES), 8 to 15 wt-% polyvinylpyrrolidone (PVP) and 60 to 80 wt-% N-alkyl-2-pyrrolidone (NAP), the centre fluid contains 60 to 70 wt-% N-alkyl-2-pyrrolidone (NAP) and 30 to 40 wt-% water, and the precipitation bath contains 70 to 82 wt-% N-alkyl-2-pyrrolidone (NAP) and 18 to 30 wt-% water. | 11-19-2009 |
20100012577 | Plasma Separation Membrane - A process for manufacturing of an asymmetric hollow fibre membrane, comprising the steps of extruding a polymer solution through the outer ring slit of a hollow fibre spinning nozzle, simultaneously extruding a centre fluid through the inner bore of the hollow fibre spinning nozzle, into a precipitation bath, whereby the polymer solution contains 10 to 26 wt-% of polysulfone (PSU), polyethersulfone (PES) or polyarylethersulfone (PAES), 8 to 15 wt-% polyvinylpyrrolidone (PVP), 55 to 75 wt-% N-alkyl-2-pyrrolidone (NAP) and 3 to 9 wt-% w ater the centre fluid contains 70 to 90 wt-% N-alkyl-2-pyrrolidone (NAP) and 10 to 30 wt-% water, and the precipitation bath contains 0 to 20 wt-% N-alkyl-2-pyrrolidone (NAP) and 80 to 100 wt-% water. | 01-21-2010 |
20100320146 | HYDROPHILIC MEMBRANES WITH A NON-IONIC SURFACTANT - The invention relates to hydrophilic membranes which are supplemented or treated with a non-ionic surfactant and processes for preparing such membranes. The membranes are particularly suitable for plasma separation or for haemodialysis and haemodiafiltration, but can also advantageously be used in other applications. Accordingly, the invention is further directed to the use of such membranes for plasma separation, plasma filtration, micro filtration, plasma therapy, haemodialysis and haemodiafiltration or cell filtration applications, respectively. The treated hydrophilic membranes show excellent biocompatibility, such as reduced platelet drop and decreased TAT levels. | 12-23-2010 |
20110031184 | Hollow Fiber Membrane and Method for Manufacturing Thereof - The present invention concerns a semipermeable hollow fiber membrane having an outer wall surface, an inner wall surface and an interior lumen extending along the length thereof and having the selective layer on the outer wall surface with a surface roughness below 10 nm. According to the invention the membrane has the smallest pore size on the outer wall surface, and has an outer wall surface which is smooth, continuous and homogeneous in a nanoscopic scale and four to five distinct layers of different pore size and density. Further the present invention concerns a process for manufacturing thereof and the use thereof. | 02-10-2011 |
20120208256 | ENZYME-FUNCTIONALIZED SUPPORTS - An immobilized enzyme comprises a solid support, an enzyme linked to the solid support and a spacer for coupling the enzyme to the solid support. A method for the production of immobilized enzymes comprises: providing a solid support having amino-functional groups coupled to the support surface; covalently coupling the amino-functional groups with a thermally labile radical initiator; and, contacting the support surface with a solution of polymerizable monomers. The polymerizable monomers comprise functional groups which do not take part in radical polymerization, under conditions where thermally initiated graft copolymerization of the monomers takes place, to form polymer chains on the surface of the support. If the polymer chains do not already comprise primary amino-functional groups, the method further comprises transforming the functional groups in the polymer chains into groups comprising primary amino-functional groups. The method further comprises coupling the enzyme to amino-functional groups of the polymer chains. | 08-16-2012 |
20140001115 | HOLLOW FIBER MEMBRANE AND METHOD FOR MANUFACTURING THEREOF | 01-02-2014 |
20140326669 | DOPED MEMBRANES - Synthetic membranes for the removal, isolation or purification of substances from a liquid. The membranes include at least one hydrophobic polymer and at least one hydrophilic polymer. 5-40 wt.-% of particles having an average particles size of between 0.1 and 15 μm are entrapped. The membrane has a wall thickness of below 150 μm. Methods for preparing the membranes in various geometries, and use of the membranes for the adsorption, isolation and/or purification of substances from a liquid are explored. | 11-06-2014 |
20150060372 | LOW CUT-OFF ULTRAFILTRATION MEMBRANES - Porous hollow fiber membranes having a low molecular weight cut-off, processes for their production, and their use for separation tasks in the fields of biotechnology, pharmaceutical technology and food processing. | 03-05-2015 |
20150273400 | HOLLOW FIBER MEMBRANE AND METHOD FOR MANUFACTURING THEREOF - The present invention concerns a semipermeable hollow fiber membrane having an outer wall surface, an inner wall surface and an interior lumen extending along the length thereof and having the selective layer on the outer wall surface with a surface roughness below 10 nm. According to the invention the membrane has the smallest pore size on the outer wall surface, and has an outer wall surface which is smooth, continuous and homogeneous in a nanoscopic scale and four to five distinct layers of different pore size and density. Further the present invention concerns a prone:is for manufacturing thereof and the use thereof. | 10-01-2015 |
20150367291 | VIRUS FILTER - The invention relates to a virus filter membrane which can be used for the removal of virus particles including parvovirus. The invention further relates to a method for producing the membrane. The membrane comprises polyacrylonitrile and polyvinylpyrrolidone. | 12-24-2015 |
20160023169 | HOLLOW FIBER MEMBRANE AND METHOD FOR MANUFACTURING THEREOF - The present invention concerns a semipermeable hollow fiber membrane having an outer wall surface, an inner wall surface and an interior lumen extending along the length thereof and having the selective layer on the outer wall surface with a surface roughness below 10 nm. According to the invention the membrane has the smallest pore size on the outer wall surface, and has an outer wall surface which is smooth, continuous and homogeneous in a nanoscopic scale and four to five distinct layers of different pore size and density. Further the present invention concerns a process for manufacturing thereof and the use thereof. | 01-28-2016 |
Patent application number | Description | Published |
20120207925 | PREMIX AND METHOD FOR PRODUCING A THERMALLY EXPANDABLE AND CURABLE EPOXY-BASED COMPOUND - A two-component premix for preparing a heat-expandable and heat-curable epoxy-based material, comprises an isocyanate, a diol or polyol, an epoxy prepolymer, a heat-activatable hardener for epoxy prepolymers, and a heat-activatable blowing agent. | 08-16-2012 |
20140037966 | IMPACT-MODIFIED ADHESIVES - The present application provides agents for producing an impact-modified epoxy adhesive encompassing at least two components A and B packaged separately from each other, wherein (a) component A contains at least one compound having two or more isocyanate groups together with one or more further additives, (b) component B contains at least one compound which has at least two reactive groups selected from hydroxyl groups, thiol groups, primary amino groups and secondary amino groups and is simultaneously free from epoxy groups, together with one or more further additives, (c) at least one of components A and/or B contains at least one epoxide prepolymer as an additive, (d) at least one of components A and/or B contains at least one latent hardener for epoxide prepolymers as an additive, and (e) components A and B contain no blowing agent that is capable of being heat activated. | 02-06-2014 |
20140039118 | HYBRID MATRIX FOR FIBER COMPOSITE MATERIALS - A fiber composite material obtainable by (a) mixing the components of a multi-component agent immediately before use, wherein component A of the multi-component agent contains at least one compound having two or more isocyanate groups, component B of the multi-component agent contains at least one compound which has at least two reactive groups selected from hydroxyl groups, thiol groups, primary amino groups and secondary amino groups and is simultaneously free from epoxy groups, and at least one of the components of the multi-component agent contains at least one epoxide prepolymer, (b) introducing the resulting application preparation into a mold in which fibers and optionally further additives are present, the resulting mixture containing at least one latent hardener for epoxide prepolymers, (c) pre-curing the resulting mixture at a temperature from 5° C. to 90° C., and (d) then finally curing the pre-cured fiber composite material at temperatures from 100° C. to 240° C., wherein the fiber composite material being removed from the mold after step (c) or step (d). | 02-06-2014 |
20150083739 | METHOD OF MANUFACTURING A COMPOSITE INSERT - A method of manufacturing a composite insert includes forming a polymer mold from a polymer sheet which may have a glass transition temperature of 70 to 160° C., the polymer mold either includes a cavity or may form a cavity disposed between the polymer mold and the carrier. The method proceeds by depositing a liquid reactive composite insert composition, which may be a two-component composition including a first part comprised of an isocyanate-epoxy blend and a second part comprised of an alcohol-epoxy blend, into the cavity under low pressure conditions of 0-10 bar and low temperature conditions of 15-100° C. The composition is then allowed to become dimensionally stable either within the polymer mold or between the polymer mold and the carrier. | 03-26-2015 |
Patent application number | Description | Published |
20100008474 | X-RAY SYSTEM - An x-ray system is provided. The x-ray system includes an x-ray emitter which can be adjusted by at least one arm as a first x-ray component and a recording system which can be adjusted independently of the at least one arm. The recording system may be adjusted by at least one additional arm as the further x-ray component. The two arms can be pivotably mounted about a common axis of rotation. | 01-14-2010 |
20100106039 | Unknown - Example embodiments relate to a device for measuring nitrogen monoxide in exhaled air by a gas sensor unit with at least one gas sensor. A device and/or method for oxidation of nitrogen monoxide to nitrogen dioxide may be included. The device and/or method for oxidation of nitrogen monoxide to nitrogen dioxide includes a non-consuming catalyst for catalyzing the oxidation of nitrogen monoxide to nitrogen dioxide. | 04-29-2010 |
20100191371 | MONITORING OF A MEDICAL DEVICE - The present embodiments relate to a monitoring system for a medical device, wherein the medical device comprises a robot and an image recording part which can be moved by the robot. Provision is made for a radiation source which is attached to the medical device, and for a radiation receiver which is situated remotely from the medical device and is for receiving radiation that is emitted from the radiation source. A comparison entity compares the point of impact of radiation on the radiation receiver with one or more predetermined points of impact of radiation on the radiation receiver. The invention further relates to a corresponding method for monitoring a medical device. | 07-29-2010 |
20110046497 | SENSOR PLATFORM FOR RESPIRATORY GAS ANALYSIS - An appliance is disclosed for measuring at least one gas analyte in exhaled air. In at least one embodiment, the appliance includes an inlet opening for the introduction of exhaled air (mouthpiece), at least one measuring chamber for receiving a sensor unit, and a conduit which provides a fluid connection from the opening to the measuring chamber, and wherein, depending on the gas analyte that is to be measured, a sensor unit with a suitable gas sensor can be introduced into the receiver. | 02-24-2011 |
20110066022 | APPARATUS FOR THE FLEXIBLE POSITIONING OF A RADIATION SOURCE AND A RADIATION DETECTOR - An apparatus for medical examinations includes a first arm that is rotatable about an axis, the first arm being configured to carry a radiation source or a radiation detector. The apparatus for medical examinations also includes a second arm that is rotatable about the axis, the second arm being configured to carry a radiation source or a radiation detector. The second arm is attached to the first arm and is rotatable relative to the first arm. | 03-17-2011 |
20110072883 | MULTIFUNCTIONAL CONTROL VALVE FOR GAS MEASUREMENT INSTRUMENTS - A multifunctional control valve for gas measurement instruments, e.g., for respiratory gas analysis, is disclosed. In at least one embodiment, the multifunctional control valve includes a first inlet opening, an outlet opening, a main line, and a bypass line, wherein a measurement chamber is in the main line, wherein the measurement chamber is arranged downstream of a first multiway valve which can selectively connect the main line or the bypass line with the inlet opening, and wherein the measurement chamber is arranged upstream of a second multiway valve which can selectively connect the main line or the bypass line with the outlet opening. | 03-31-2011 |
20110077544 | METHOD FOR OPTIMIZING THE GAS CONVERSION RATE IN A RESPIRATORY GAS ANALYZER - A method for optimizing a gas conversion rate in a respiratory gas analyzer, more particularly for nitric oxide (NO) in the respiratory gas, and an associated device are disclosed. | 03-31-2011 |
20110313257 | Method for Recording and Evaluation of Measurements Related to the Condition of a Patient for Configuration of a Portable, Patient-Controlled Device Operated to Record Said Measurements and Related Device - In a method for recording and evaluating measurements related to the condition of a patient for configuration of a portable, patient-controlled device operated to record the measurements,—at least one measurement describing the condition of the patient is recorded by the device,—the measurement and/or at least one parameter derived therefrom is/are transferred to an evaluation device via a communication connection,—the measurement and/or the parameter is/are evaluated by or on the evaluation device by an expert system and/or an expert to determine patient-specific information,—configuration data ascertained in consideration of the patient-specific information is transferred back to the device via the or another communication connection, and—the device is configured according to the configuration data. | 12-22-2011 |
20120065535 | GAS ANALYSIS APPARATUS HAVING A COMBINATION OF GAS DEHUMIDIFIER AND GAS CONVERTER - An apparatus for measuring nitrogen monoxide in exhaled air by way of a gas sensor unit ( | 03-15-2012 |
20120201352 | METHOD FOR OBTAINING A 3D IMAGE DATASET OF AN OBJECT OF INTEREST - A method for obtaining a 3D image dataset of an object of interest is proposed. A plurality of 2D X-ray images are captured and a 3D reconstruction is carried out using filtered back projection. The projection parameters have been measured with the aid of a calibrating phantom, possibly using an interpolation or extrapolation of such measurements. A model of effect strings of the components in an X-ray imaging device is obtained, and the model parameters are identified based on imaging of a calibrating phantom. A projection matrix can then be calculated for any positions on any desired trajectories, without having to use imaging of a calibrating phantom at precisely that position and desired trajectory. | 08-09-2012 |
20130066335 | METHOD FOR MOVING AN INSTRUMENT ARM OF A LAPAROSCOPY ROBOT INTO A PREDETERMINABLE RELATIVE POSITION WITH RESPECT TO A TROCAR - A method for moving an instrument aim of a laparoscopy robot into a predeterminable position relative to a trocar placed in a patient is proposed. A spatial marker that can be localized from outside of the patient is applied to the trocar. The spatial position of the trocar is detected based on the spatial marker. The intended position of the instrument arm is established from the spatial position and the relative position. The actual position of the instrument arm is detected. The instrument arm is moved into the intended position based on the actual position, the intended position and an error minimization method. | 03-14-2013 |
20130070907 | X-RAY DEVICE - The present embodiments relate to an x-ray device that includes at least one x-ray emitter and a recording system provided to detect x-ray radiation as separately displaceable x-ray components of the x-ray device. Two arms, each at least indirectly supporting an x-ray component, may be positioned in a ring structure. The ring structure is formed with the aid of a suitable shoulder joint construction supporting the two arms, such that the two arms are largely supported orthogonally to one another and may rotate about a common rotation axis. | 03-21-2013 |
20130231682 | INSTRUMENT FOR A MANIPULATOR ARM OF AN ENDOSCOPIC ROBOT - An instrument for a manipulator arm of an endoscopic robot is provided. The instrument has a treatment head for carrying out a medical measure in a patient, an instrument base carrying the treatment head, a coupling element that can be fastened to the manipulator arm, and a sterilizable sleeve enclosing the instrument and having at least one opening which can be sealingly placed on the instrument base. The coupling element protrudes from the opening. | 09-05-2013 |
20130245370 | INSTRUMENT SYSTEM - An instrument system is provided. The instrument system has an endoscopic instrument with a work head that is mounted on one end of a flexible support arm and can be inserted into a patient. The instrument system has a trocar that can be placed in the body surface of the patient and has a main body which can be fixed in position relative to the patient and which has a through-opening for the instrument, a guide body which, when the instrument is inserted, encloses and guides a longitudinal portion of the support arm with a guide channel in such a way that a spatial guiding direction of the support arm is defined at least thereon, with an adjustment element acting on the guide body and allowing a specific change of a relative position of the guiding direction with respect to the main body. | 09-19-2013 |
Patent application number | Description | Published |
20090111765 | COMPOSITIONS AND METHODS FOR IMMUNOSTIMULATORY RNA OLIGONUCLEOTIDES - The present invention provides 4-nucleotide (4mer) RNA motifs that confer immunostimulatory activity, in particular, IL-12-inducing activity to a single-stranded RNA oligonucleotide. The present invention also provides single-stranded RNA oligonucleotides, including antisense RNA, with high or low immunostimulatory activity. The present invention further provides the use of the RNA oligonucleotides of the invention for therapeutic purposes. | 04-30-2009 |
20090169529 | COMPOSITIONS AND METHODS FOR IMMUNOSTIMULATORY RNA OLIGONUCLEOTIDES - The present invention provides 4-nucleotide (4mer) RNA motifs that confer immunostimulatory activity, in particular, IFN-α-inducing activity to a RNA oligonucleotide. The present invention also provides RNA oligonucleotides, including siRNA, with high or low immunostimulatory activity. The present invention further provides the use of the RNA oligonucleotides of the invention for therapeutic purposes. | 07-02-2009 |
20100120894 | Intracellular DNA receptor - Provided herein are methods of identifying and using compounds that modulate an AIM2 polypeptide-mediated immune response. Further provided herein are methods of treating disease comprising administering to a patient a compound that decreases expression of an AIM2 polypeptide. Further provided herein are methods of providing gene therapy to a patient comprising administering to the patient a gene therapy agent and a compound that decreases expression of an AIM2 polypeptide. In certain embodiments, a compound that decreases expression of an AIM2 polypeptide comprises an siRNA or an shRNA. | 05-13-2010 |
20100178272 | STRUCTURE AND USE OF 5'PHOSPHATE OLIGONUCLEOTIDES - Oligonucleotides bearing free, uncapped 5′ phosphate group(s) are recognized by RIG-I, leading to the induction of type I IFN, IL-18 and IL-1β production. Bacterial RNA also induces type I IFN production. 5′ phosphate oligonucleotides and bacterial RNA can be used for inducing an anti-viral response or an anti-bacterial response, in particular, type I IFN and/or IL-18 and/or IL-1β production, in vitro and in vivo and for treating various disorders and diseases such as viral infections, bacterial infections, parasitic infections, tumors, allergies, autoimmune diseases, immunodeficiencies and immunosuppression. Single-stranded 5′ triphosphate RNA can be used for inducing an anti-viral response, an anti-bacterial response, or an anti-tumor response, in particular, type I IFN and/or IL-18 and/or IL-1β production, in a target cell-specific manner. | 07-15-2010 |
20120045461 | Compositions and Methods for Inducing an Immune Response in a Mammal and Methods of Avoiding an Immune Response to Oligonucleotide Agents Such as Short Interfering RNAs - Tis invention provides oligonucleotide agents that modulate an immune response by stimulating IFN production and methods of using such agents for therapeutic treatments of mammals. | 02-23-2012 |
20120121551 | COMPOSITIONS AND METHODS FOR IMMUNOSTIMULATORY RNA OLIGONUCLEOTIDES - The present invention provides 4-nucleotide (4mer) RNA motifs that confer immunostimulatory activity, in particular, IFN-α-inducing activity to a RNA oligonucleotide. The present invention also provides RNA oligonucleotides, including siRNA, with high or low immunostimulatory activity. The present invention further provides the use of the RNA oligonucleotides of the invention for therapeutic purposes. | 05-17-2012 |
20120288476 | STRUCTURE AND USE OF 5' PHOSPHATE OLIGONUCLEOTIDES - Oligonucleotides bearing free, uncapped 5′ phosphate group(s) are recognized by RIG-I, leading to the induction of type I IFN, IL-18 and IL-1β production. Bacterial RNA also induces type I IFN production. 5′ phosphate oligonucleotides and bacterial RNA can be used for inducing an anti-viral response or an anti-bacterial response, in particular, type I IFN and/or IL-18 and/or IL-1β production, in vitro and in vivo and for treating various disorders and diseases such as viral infections, bacterial infections, parasitic infections, tumors, allergies, autoimmune diseases, immunodeficiencies and immunosuppression. Single-stranded 5′ triphosphate RNA can be used for inducing an anti-viral response, an anti-bacterial response, or an anti-tumor response, in particular, type I IFN and/or IL-18 and/or IL-1β production, in a target cell-specific manner. | 11-15-2012 |
20130158100 | INTRACELLULAR DNA RECEPTOR - Provided herein are methods of identifying and using compounds that modulate an AIM2 polypeptide-mediated immune response. Further provided herein are methods of treating disease comprising administering to a patient a compound that decreases expression of an AIM2 polypeptide. Further provided herein are methods of providing gene therapy to a patient comprising administering to the patient a gene therapy agent and a compound that decreases expression of an AIM2 polypeptide. In certain embodiments, a compound that decreases expression of an AIM2 polypeptide comprises an siRNA or an shRNA. | 06-20-2013 |
20160051573 | STRUCTURE AND USE OF 5' PHOSPHATE OLIGONUCLEOTIDES - Oligonucleotides bearing free, uncapped 5′ phosphate group(s) are recognized by RIG-I, leading to the induction of type I IFN, IL-18 and IL-1β production. Bacterial RNA also induces type I IFN production. 5′ phosphate oligonucleotides and bacterial RNA can be used for inducing an anti-viral response or an anti-bacterial response, in particular, type I IFN and/or IL-18 and/or IL-1β production, in vitro and in vivo and for treating various disorders and diseases such as viral infections, bacterial infections, parasitic infections, tumors, allergies, autoimmune diseases, immunodeficiencies and immunosuppression. Single-stranded 5′ triphosphate RNA can be used for inducing an anti-viral response, an anti-bacterial response, or an anti-tumor response, in particular, type I IFN and/or IL-18 and/or IL-1β production, in a target cell-specific manner. | 02-25-2016 |