Patent application number | Description | Published |
20100004313 | Modified Poloxamers for Gene Expression and Associated Methods - Nucleotide delivery polymers, compositions, and associated methods for the enhancement of gene delivery and expression in solid tissues are provided. In one aspect, for example, a nucleotide delivery polymer may include a poloxamer backbone having a metal chelator covalently coupled to at least one terminal end of the poloxamer backbone. In another aspect, the nucleotide expression polymer has a metal chelator coupled to at least two terminal ends of the poloxamer backbone. | 01-07-2010 |
20100004315 | Biodegradable Cross-Linked Branched Poly(Alkylene Imines) - Disclosed is a cross-linked branched poly(alkylenimine) and compositions thereof and nucleotide molecules. Also disclosed are methods for preparing the cross-linked branched poly(alkylenimine). | 01-07-2010 |
20100260817 | Polyamine Derivatives - Disclosed are compounds, compositions and methods for systemic and local delivery of biologically active molecules. | 10-14-2010 |
20120009145 | Biodegradable Cross-Linked Cationic Multi-block Copolymers for Gene Delivery and Methods of Making Thereof - A biodegradable cross-linked cationic multi-block copolymer of linear polyethylenimine (LPEI) wherein the LPEI blocks are linked together by hydrophilic linkers with a biodegradable disulfide bond and methods of making thereof. The biodegradable cross-linked cationic multi-block copolymer may also contain pendant functional moieties which are preferably receptor ligands, membrane permeating agents, endosomolytic agents, nuclear localization sequences, pH sensitive endosomolytic peptides, chromogenic or fluorescent dyes. | 01-12-2012 |
20130251809 | Polyamine Derivatives - Disclosed are compounds, compositions and methods for systemic and local delivery of biologically active molecules. | 09-26-2013 |
20140050775 | Polyamine Derivatives - Disclosed are compounds, compositions and methods for systemic and local delivery of biologically active molecules. | 02-20-2014 |
20150099000 | Polyamine Derivatives - Disclosed are compounds, compositions and methods for systemic and local delivery of biologically active molecules. | 04-09-2015 |