Costales
Abran Costales, Emeryville, CA US
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20100004237 | 2-Amino-7,8-dihydro-6H-pyrido[4,3-D]pyrimidin-5-ones - Disclosed are 2-amino-7,8-dihydro-6H-pyrido[4,3-d]pyrimidin-5-one compounds, their stereoisomers, tautomers, pharmaceutically acceptable salts, and prodrugs thereof; compositions that include a pharmaceutically acceptable carrier and one or more of the 2-amino-7,8-dihydro-6H-pyrido[4,3-d]pyrimidin-5-one compounds, either alone or in combination with at least one additional therapeutic agent. Disclosed also are methods of using the 2-amino-7,8-dihydro-6H-pyrido[4,3-d]pyrimidin-5-one compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of cellular proliferative, viral, autoimmune, cardiovascular, and central nervous system diseases. | 01-07-2010 |
20100075965 | PI3 KINASE INHIBITORS AND METHODS OF THEIR USE - Phosphatidylinositol (PI) 3 kinase inhibitor compounds, their pharmaceutically acceptable salts, and prodrugs thereof; compositions of the new compounds, either alone or in combination with at least one additional therapeutic agent, with a pharmaceutically acceptable carrier; and uses of the new compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of proliferative diseases characterized by the abnormal activity of growth factors, protein serine/threonine kinases, phospholipid kinases, G-protein coupled receptors, and phosphatases. | 03-25-2010 |
Abran Costales, El Cerrito, CA US
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20090035309 | Substituted Benzazoles and Methods of Their Use as Inhibitors of RAF Kinase - New substituted benzazole compounds, compositions and methods of inhibition of Raf kinase activity in a human or animal subject are provided. The new compounds compositions may be used either alone or in combination with at least one additional agent for the treatment of a Raf kinase mediated disorder, such as cancer. | 02-05-2009 |
20130224195 | SUBSTITUTED BENZAZOLES AND METHODS OF THEIR USE AS INHIBITORS OF RAF KINASE - New substituted benzazole compounds, compositions and methods of inhibition of Raf kinase activity in a human or animal subject are provided. The new compounds compositions may be used either alone or in combination with at least one additional agent for the treatment of a Raf kinase mediated disorder, such as cancer. | 08-29-2013 |
Abran Q. Costales, Emeryville, CA US
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20110052578 | Compounds and Compositions as Protein Kinase Inhibitors - The present invention provides compounds of Formula I or II: | 03-03-2011 |
20120225899 | Compounds and Compositions as Protein Kinase Inhibitors - The present invention provides compounds of Formula I or II: | 09-06-2012 |
20140011825 | Compounds and Compositions as Protein Kinase Inhibitors - The present invention provides compounds of Formula I or II: | 01-09-2014 |
Abran Q. Costales, El Cerrito, CA US
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20140235620 | 3-PYRIMIDIN-4-YL-OXAZOLIDIN-2-ONES AS INHIBITORS OF MUTANT IDH - The invention is directed to a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein R | 08-21-2014 |
20140275083 | 3-PYRIMIDIN-4-YL-OXAZOLIDIN-2-ONES AS INHIBITORS OF MUTANT IDH - The invention is directed to a formula (I): | 09-18-2014 |
20150152093 | 3-PYRIMIDIN-4-YL-OXAZOLIDIN-2-ONES AS INHIBITORS OF MUTANT IDH - The invention is directed to a formula (I): | 06-04-2015 |
Bryan Costales, San Francisco, CA US
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20120215892 | SYSTEM AND METHOD TO CUSTOMIZE DNS REPLIES BASED ON CONNECTION IDENTITY - A highly advantageous domain name system and method are disclosed for receiving and replying to queries for information associated with at least one Internet connected domain in which replies to queries are based at least in part on the identity of the querying entity. | 08-23-2012 |
Edward Costales, West Sacramento, CA US
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20110154069 | DYNAMIC POWER STATE DETERMINATION - According to some embodiments, a method and apparatus are provided to determine a first operating point and a second operating point associated with a graphics processing unit, automatically determine a plurality of voltage/frequency values between the first operating point and the second operating point, and define a plurality of power states of the graphic processing unit. One or more of the power states may be associated with one of the plurality of voltage/frequency values. Each of the plurality of voltage/frequency values may include both a voltage and a frequency. | 06-23-2011 |
20130127811 | SWITCHING DISPLAY UPDATE PROPERTIES UPON DETECTING A POWER MANAGEMENT EVENT - Systems and methods provide automatic switching of display update properties such as screen resolution, pixel depth, and refresh rate in response to a power management event. The display update property may be decreased when power is switched from AC power to DC power, for example, when the system is unplugged from a wall outlet and is running on battery power. | 05-23-2013 |
Edward P. Costales, West Sacramento, CA US
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20090160841 | SWITCHING DISPLAY UPDATE PROPERTIES UPON DETECTING A POWER MANAGEMENT EVENT - Systems and methods provide automatic switching of display update properties such as screen resolution, pixel depth, and refresh rate in response to a power management event. The display update property may be decreased when power is switched from AC power to DC power, for example, when the system is unplugged from a wall outlet and is running on battery power. | 06-25-2009 |
James B. Costales, Winchester, MA US
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20150186566 | INJECTION OF SIMULATED SOURCES IN A SYSTEM OF NETWORKED SENSORS - Simulated sources can be injected into a networked system for use in training and/or testing. | 07-02-2015 |
Jerry J. Costales, Fullerton, CA US
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20130045315 | FIBER PARTICLE SIZE REDUCTION IN FIBER-CONTAINING FOOD SLURRIES - Techniques are described to increase product viscosity in fiber-containing food slurries having a given amount of food solids. The techniques employ one or more PSR operations as the last unit operation prior to filling to reduce particle size within the food slurry and increase product viscosity. In one or more implementations, the PSR operation may comprise an aseptic cold PSR operation such as aseptic cold homogenization. In embodiments, the PSR operation may further be controlled to reduce variability in the viscosity of the finished product. | 02-21-2013 |
Paul Costales, Santa Barbara, CA US
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20100275334 | Modular atomic force microscope - A modular AFM/SPM which provides faster measurements, in part through the use of smaller probes, of smaller forces and movements, free of noise artifacts, that the old generations of these devices have increasingly been unable to provide. The modular AFM/SPM includes a chassis, the foundation on which the modules of the instrument are supported; a view module providing the optics for viewing the sample and the probe; a head module providing the components for the optical lever arrangement and for steering and focusing those components; a scanner module providing the XYZ translation stage that actuates the sample in those dimensions and the engage mechanism; a isolation module that encloses the chassis and provides acoustic and/or thermal isolation for the instrument and an electronics module which, together with the separate controller, provide the electronics for acquiring and processing images and controlling the other functions of the instrument. All these modules and many of their subassemblies are replaceable and potentially upgradeable. This allows updating to new technology as it becomes available. | 10-28-2010 |
20140223612 | Modular Atomic Force Microscope - A modular AFM/SPM which provides faster measurements, in part through the use of smaller probes, of smaller forces and movements, free of noise artifacts, that the old generations of these devices have increasingly been unable to provide. The modular AFM/SPM includes a chassis, the foundation on which the modules of the instrument are supported; a view module providing the optics for viewing the sample and the probe; a head module providing the components for the optical lever arrangement and for steering and focusing those components; a scanner module providing the XYZ translation stage that actuates the sample in those dimensions and the engage mechanism; a isolation module that encloses the chassis and provides acoustic and/or thermal isolation for the instrument and an electronics module which, together with the separate controller, provide the electronics for acquiring and processing images and controlling the other functions of the instrument. All these modules and many of their subassemblies are replaceable and potentially upgradeable. This allows updating to new technology as it becomes available. | 08-07-2014 |
Rene Oriendo Costales, Baguio City PH
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20080296355 | Direct ball dispenser - In a method and apparatus for dispensing solder balls, a container having an opening for dispensing solder balls is positioned to enable a flow of the solder balls through the opening. The solder balls have a common configurable solder ball diameter. A proximal opening of a tube is coupled to the opening of the container. A distal opening of the tube is coupled to a nozzle. The nozzle has a nozzle orifice that is configured in accordance with the solder ball diameter to dispense the solder balls into a ball bin. A hopper vibrator is coupled to the nozzle to impart vibration energy to the nozzle, thereby providing a stimulus to the flow. A tool head picks selected ones of the solder balls from the ball bin for an assembly of a semiconductor device. | 12-04-2008 |
Thomas Jay Costales, League City, TX US
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20130157736 | Systems and Methods for Playing and Managing Virtual Activities Via User Devices - Generally, systems and methods for playing and managing electronic games via a mobile device. According to one aspect, users can be located at geographically distributed activity centers (e.g., bowling alleys, golf courses, etc.). Further aspects of the present disclosure generally relate to engaging in challenges with other mobile device users via a mobile software application, wherein the challenges are based on live, in-person activities. Specifically, a user of an embodiment of the present system is able to link scores, statistics, and other information corresponding to an in-person activity (or game) to a virtual environment, thus enabling the user to “play” against another user (often in a separate geographical location) based on the other user's actual, in-person activity. | 06-20-2013 |