Stewart, MA
Alex Stewart, Waltham, MA US
Patent application number | Description | Published |
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20080232545 | TOMOSYNTHESIS IMAGING SYSTEM AND METHOD - A system for three-dimensional tomosynthesis imaging of a target element is provided having an image acquisition element and a processor. The image acquisition element obtains a plurality of images of the target element from a plurality of angles and includes a radiation source that is positionable at a plurality of angles with respect to the target element and a radiation detector. The radiation detector is positioned so as to detect radiation emitted by the radiation source passing through the target element and determine a plurality of attenuation values for radiation passing through the target element to establish a radiation absorbance projection image of the target element for a particular radiation source angle. The processor is configured to apply an iterative reconstruction algorithm to the radiation absorbance projection images of the target element obtained from a plurality of radiation source angles to generate a three-dimensional reconstruction of the target element. The system can gain further accuracy where the iterative reconstruction algorithm is applied using cone-beam forward projection and back projection. | 09-25-2008 |
20100221752 | Ovarian Cancer Biomarkers and Uses Thereof - The present application includes biomarkers, methods, devices, reagents, systems, and kits for the detection and diagnosis of ovarian cancer. In one aspect, the application provides biomarkers that can be used alone or in various combinations to diagnose ovarian cancer or permit the differential diagnosis of a pelvic mass as benign or malignant. In another aspect, methods are provided for diagnosing ovarian cancer in an individual, where the methods include detecting, in a biological sample from an individual, at least one biomarker value corresponding to at least one biomarker selected from the group of biomarkers provided in Table 1, wherein the individual is classified as having ovarian cancer, or the likelihood of the individual having ovarian cancer is determined, based on the at least one biomarker value. | 09-02-2010 |
Alex A.e. Stewart, Waltham, MA US
Patent application number | Description | Published |
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20100070191 | Lung Cancer Biomarkers and Uses Thereof - The present application includes biomarkers, methods, devices, reagents, systems, and kits for the detection and diagnosis of lung cancer. In one aspect, the application provides biomarkers that can be used alone or in various combinations to diagnose lung cancer or permit the differential diagnosis of pulmonary nodules as benign or malignant. In another aspect, methods are provided for diagnosing lung cancer in an individual, where the methods include detecting, in a biological sample from an individual, at least one biomarker value corresponding to at least one biomarker selected from the group of biomarkers provided in Table 1, Col. 2, wherein the individual is classified as having lung cancer, or the likelihood of the individual having lung cancer is determined, based on the at least one biomarker value. | 03-18-2010 |
20100086948 | Ovarian Cancer Biomarkers and Uses Thereof - The present application includes biomarkers, methods, devices, reagents, systems, and kits for the detection and diagnosis of ovarian cancer. In one aspect, the application provides biomarkers that can be used alone or in various combinations to diagnose ovarian cancer or permit the differential diagnosis of a pelvic mass as benign or malignant. In another aspect, methods are provided for diagnosing ovarian cancer in an individual, where the methods include detecting, in a biological sample from an individual, at least one biomarker value corresponding to at least one biomarker selected from the group of biomarkers provided in Table 1, wherein the individual is classified as having ovarian cancer, or the likelihood of the individual having ovarian cancer is determined, based on the at least one biomarker value. | 04-08-2010 |
20120077695 | Mesothelioma Biomarkers and Uses Thereof - The present disclosure includes biomarkers, methods, devices, reagents, systems, and kits for the detection and diagnosis of cancer. In one aspect, methods are provided for diagnosing mesothelioma where the methods include detecting, in a biological sample, at least one biomarker value corresponding to at least one biomarker selected from the biomarkers provided in Table 1, wherein an individual is classified as having mesothelioma, or the likelihood of an individual having mesothelioma is determined, based on the at least one biomarker value. In another aspect, methods are provided for diagnosing cancer generally where the methods include detecting, in a biological sample at least one biomarker value corresponding to at least one biomarker selected from the biomarkers provided in Table 17, wherein an individual is classified as having cancer generally, or the likelihood of an individual having cancer is determined, based on the at least one biomarker value. | 03-29-2012 |
20120101002 | Lung Cancer Biomarkers and Uses Thereof - The present disclosure includes biomarkers, methods, devices, reagents, systems, and kits for the detection and diagnosis of non-small cell lung cancer and general cancer. In one aspect, methods are provided for diagnosing non-small cell lung cancer, where the methods include detecting, in a sample, at least one biomarker value corresponding to at least one biomarker selected from the biomarkers provided in Table 1, wherein an individual is classified as having lung cancer, or the likelihood of having lung cancer is determined, based on the at least one biomarker value. In another aspect, methods are provided for diagnosing cancer, where the methods include detecting, in a sample, at least one biomarker value corresponding to at least one biomarker selected from the biomarkers provided in Table 19, wherein an individual is classified as having cancer, or the likelihood of having cancer is determined, based on the at least one biomarker value. | 04-26-2012 |
20120143805 | Cancer Biomarkers and Uses Thereof - The present disclosure includes biomarkers, methods, devices, reagents, systems, and kits for the detection and diagnosis of cancer. In one aspect, the disclosure provides biomarkers that can be used alone or in various combinations to diagnose cancer. In another aspect, methods are provided for diagnosing cancer in an individual, where the methods include detecting, in a biological sample from an individual, at least one biomarker value corresponding to at least one biomarker selected from the group of biomarkers provided in Table 47, wherein the individual is classified as having cancer, or the likelihood of the individual having cancer is determined, based on the at least one biomarker value. | 06-07-2012 |
20120165217 | Cancer Biomarkers and Uses Thereof - The present disclosure includes biomarkers, methods, devices, reagents, systems, and kits for the detection and diagnosis of cancer. In one aspect, the disclosure provides biomarkers that can be used alone or in various combinations to diagnose cancer. In another aspect, methods are provided for diagnosing cancer in an individual, where the methods include detecting, in a biological sample from an individual, at least one biomarker value corresponding to at least one biomarker selected from the group of biomarkers provided in Table 24, wherein the individual is classified as having cancer, or the likelihood of the individual having cancer is determined, based on the at least one biomarker value. | 06-28-2012 |
20130065782 | Renal Cell Carcinoma Biomarkers and Uses Thereof - The subject disclosure concerns methods for evaluation of renal cell carcinoma (RCC). Such methods include a method of determining of a diagnosis of the individual as having or not having RCC; determination of a prognosis of a future course of RCC; determination of disease burden; or determination of recurrence of RCC in an individual who had been apparently cured of RCC. The methods each involve the detection of the value of at least one biomarker of Table 1. The biomarker value is used, in some of the methods, to determine whether the individual does or does not demonstrate evidence of disease, and in another method, to determine the degree or a score indicative of the individual's extent of disease. | 03-14-2013 |
20130085079 | Cardiovascular Risk Event Prediction and Uses Thereof - The present disclosure includes biomarkers, methods, devices, reagents, systems, and kits for the evaluation of risk of a caradiovascular (CV) Event within 5 years. In one aspect, the disclosure provides biomarkers that can be used alone or in various combinations to evaluate risk of a CV event within 5 years. In another aspect, methods are provided for evaluating risk of a CV event within 5 years in an individual, where the methods include detecting, in a biological sample from an individual, at least one biomarker value corresponding to at least one biomarker selected from the group of biomarkers provided in Table 1. In a further aspect, methods are provided for evaluating the risk of a CV, where the methods include detecting, in a biological sample from an individual, at least one biomarker value corresponding to at least one biomarker selected from the group of biomarkers provided in Table 2. In a further aspect, methods are provided for evaluating the risk of a CV event in an individual, generally within 5 years, where the methods include detecting, in a biological sample from an individual, at least one biomarker value corresponding to at least one biomarker selected from the group of biomarkers provided in Table 3. | 04-04-2013 |
20130103321 | Selection of Preferred Sample Handling and Processing Protocol for Identification of Disease Biomarkers and Sample Quality Assessment - The subject invention relates to methods for obtaining biological samples of improved quality. It encompasses the identification of markers or proteins in biological samples that are altered due to variations in sample collection, handling and processing. They are also useful for correcting variations in measured results for disease biomarkers. Further, they can permit the rejection of samples or groups of samples as necessary if it is determined that their collection method was not in accordance with the predetermined protocol. Other advantages useful to the skilled artisan are described herein. | 04-25-2013 |
20140073521 | Mesothelioma Biomarkers and Uses Thereof - The present disclosure includes biomarkers, methods, devices, reagents, systems, and kits for the detection and diagnosis of cancer. In one aspect, methods are provided for diagnosing mesothelioma where the methods include detecting, in a biological sample, at least one biomarker value corresponding to at least one biomarker selected from the biomarkers provided in Table 1, wherein an individual is classified as having mesothelioma, or the likelihood of an individual having mesothelioma is determined, based on the at least one biomarker value. In another aspect, methods are provided for diagnosing cancer generally where the methods include detecting, in a biological sample at least one biomarker value corresponding to at least one biomarker selected from the biomarkers provided in Table 17, wherein an individual is classified as having cancer generally, or the likelihood of an individual having cancer is determined, based on the at least one biomarker value. | 03-13-2014 |
20140135302 | CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD) BIOMARKERS AND USES THEREOF - Methods, compositions, and kits for predicting whether a subject with chronic obstructive pulmonary disease (COPD) or at risk of developing COPD is likely to have progressive COPD are provided. Methods, compositions, and kits for predicting whether lung function is likely to decline in a subject with COPD or at risk for developing COPD are also provided. | 05-15-2014 |
20150160225 | Renal Cell Carcinoma Biomarkers and Uses Thereof - The subject disclosure concerns methods for evaluation of renal cell carcinoma (RCC). Such methods include a method of determining of a diagnosis of the individual as having or not having RCC; determination of a prognosis of a future course of RCC; determination of disease burden; or determination of recurrence of RCC in an individual who had been apparently cured of RCC. The methods each involve the detection of the value of at least one biomarker of Table 1. The biomarker value is used, in some of the methods, to determine whether the individual does or does not demonstrate evidence of disease, and in another method, to determine the degree or a score indicative of the individual's extent of disease. | 06-11-2015 |
20150377903 | CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD) BIOMARKERS AND USES THEREOF - Methods, compositions, and kits for predicting whether a subject with chronic obstructive pulmonary disease (COPD) or at risk of developing COPD is likely to have progressive COPD are provided. Methods, compositions, and kits for predicting whether lung function is likely to decline in a subject with COPD or at risk for developing COPD are also provided. | 12-31-2015 |
Alexander Stewart, Waltham, MA US
Patent application number | Description | Published |
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20090262893 | METHODS AND APPARATUS FOR OBTAINING LOW-DOSE IMAGING - In one aspect, a method of obtaining projection data of an object from a plurality of view angles with respect to the object is provided. The method comprises acts of providing radiation, at each of the plurality of view angles, to an exposure area in which the object is positioned, controlling a radiation energy of the radiation provided at each of the plurality of view angles such that the respective radiation energy is different for at least two of the plurality of view angles, and detecting at least some of the radiation passing through the exposure area at each of the plurality of view angles to obtain the projection data. | 10-22-2009 |
20090274272 | METHODS AND APPARATUS FOR OBTAINING LOW-DOSE IMAGING - In one aspect, A method of imaging an object of interest positioned in an exposure area is provided. The method comprises obtaining projection data of the object by providing radiation to the exposure area and detecting at least some of the radiation exiting the object to form the projection data, performing a first reconstruction of the projection data to form at least one bootstrap image, obtaining first data based on information provided by the at least one bootstrap image, and performing a second reconstruction of the projection data based, at least in part, on the first data to form at least one second image. | 11-05-2009 |
20110012897 | Methods and apparatus for displaying images - In one aspect, a method of displaying data is provided. The method comprises obtaining projection data of an object by exposing an object to radiation at a plurality of view angles and detecting at least some of the radiation exiting the object to form the projection data, operating a computer to reconstruct the projection data at a reconstruction resolution to form image data comprising a plurality of voxels representing locations within the object, each of the plurality of voxels being assigned an associated intensity indicative of a density of the subject matter at the respective location, determining a maximum resolution for display, above which variation in intensity between adjacent voxels is not supported by information in the projection data, the maximum resolution being less than the reconstruction resolution, and displaying the image data at or below the maximum resolution. | 01-20-2011 |
20120219202 | METHODS AND APPARATUS FOR DISPLAYING IMAGES - In one aspect, a method of displaying data is provided. The method comprises obtaining projection data of an object by exposing an object to radiation at a plurality of view angles and detecting at least some of the radiation exiting the object to form the projection data, operating a computer to reconstruct the projection data at a reconstruction resolution to form image data comprising a plurality of voxels representing locations within the object, each of the plurality of voxels being assigned an associated intensity indicative of a density of the subject matter at the respective location, determining a maximum resolution for display, above which variation in intensity between adjacent voxels is not supported by information in the projection data, the maximum resolution being less than the reconstruction resolution, and displaying the image data at or below the maximum resolution. | 08-30-2012 |
Alison Stewart, Cambridge, MA US
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20130338092 | COMPOUNDS AND METHODS FOR TARGETING LEUKEMIC STEM CELLS - This invention relates to high-throughput, semi-automated methods for identifying compounds that are effective in targeting leukemia stem cells, as well as compounds identified by those methods and uses thereof for treating leukemia. | 12-19-2013 |
Alistair Stewart, Somerville, MA US
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20080213217 | Enantiomerically pure phosphoindoles as HIV inhibitors - 3-phosphoindole compounds substantially in the form of a single enantiomer useful for the treatment of Flaviviridae virus infections, and particularly for HIV infections are provided. Also provided are pharmaceutical compositions comprising the 3-phosphoindole compounds alone or in combination with one or more other anti-viral agents, processes for their preparation, and methods of manufacturing a medicament incorporating these compounds. | 09-04-2008 |
20110257129 | ENANTIOMERICALLY PURE PHOSPHOINDOLES AS HIV INHIBITORS - 3-phosphoindole compounds substantially in the form of a single enantiomer useful for the treatment of Flaviviridae virus infections, and particularly for HIV infections are provided. Also provided are pharmaceutical compositions comprising the 3-phosphoindole compounds alone or in combination with one or more other anti-viral agents, processes for their preparation, and methods of manufacturing a medicament incorporating these compounds. | 10-20-2011 |
Alistair James Stewart, Wayland, MA US
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20160083413 | 2'-CHLORO NUCLEOSIDE ANALOGS FOR HCV INFECTION - Provided herein are compounds, compositions and methods for the treatment of Flaviviridae infections, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents. In certain embodiments, the compounds are 2′-chloro nucleosides according to Formula 2001: | 03-24-2016 |
Alistair James Stewart, Lincoln, MA US
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20130217644 | Pharmaceutical Compositions of 2'-C-Methyl-Guanosine, 5'-[2[(3-Hydroxy-2,2-Dimethyl-1-Oxopropyl)Thio]Ethyl N-(Phenylmethyl)Phosphoramidate] - Provided herein are pharmaceutical compositions, and in particular, oral pharmaceutical compositions, and methods of using these pharmaceutical compositions in the treatment of viral infections, including hepatitis C virus infections in hosts in need thereof. In certain embodiments, pharmaceutical compositions of 2′-C-methyl-guanosine, 5′-[2-[(3-hydroxy-2,2-dimethyl-1-oxopropyl)thio]ethyl N-(phenylmethyl)phosphoramidate] are provided which display remarkable efficacy and bioavailability for the treatment of, for example, HCV infection in a human. | 08-22-2013 |
20130315866 | 3',5'-CYCLIC PHOSPHORAMIDATE PRODRUGS FOR HCV INFECTION - Provided herein are compounds, compositions and methods for the treatment of Flaviviridae infections, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents. | 11-28-2013 |
20130315868 | D-AMINO ACID COMPOUNDS FOR LIVER DISEASE - Provided herein are compounds, compositions and methods for the treatment of liver disease and conditions, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents. | 11-28-2013 |
20140112887 | 2',4'-BRIDGED NUCLEOSIDES FOR HCV INFECTION - Provided herein are compounds, compositions and methods for the treatment of Flaviviridae infections, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents. In certain embodiments, the compounds are 2′,4′-bridged nucleosides which display remarkable efficacy and bioavailability for the treatment of, for example, HCV infection in a human. In certain embodiments, the 2′,4′-bridged nucleosides are of Formula 3001: | 04-24-2014 |
20140178338 | 4'-FLUORO NUCLOSIDES FOR THE TREATMENT OF HCV - Provided herein are compounds, compositions and methods for the treatment of Flaviviridae infections, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents. In certain embodiments, the compounds are according to Formula 1501: | 06-26-2014 |
20140248241 | 3'-DEOXY NUCLEOSIDES FOR THE TREATMENT OF HCV - Provided herein are compounds, compositions and methods for the treatment of Flaviviridae infections, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents. In certain embodiments, the compounds are 3′-deoxy nucleoside compounds according to Formula 3001a or 3001b: | 09-04-2014 |
20140248242 | THIOPHOSPHATE NUCLEOSIDES FOR THE TREATMENT OF HCV - Provided herein are compounds, compositions and methods for the treatment of Flaviviridae infections, including HCV infections. In certain embodiments, the compounds are according to Formula 2001: | 09-04-2014 |
20140294769 | 2',4'-FLUORO NUCLEOSIDES FOR THE TREATMENT OF HCV - Provided herein are compounds, methods and pharmaceutical compositions for use in treatment of viral infections, including hepatitis C virus (HCV) infections, in hosts in need thereof. In certain embodiments, the compounds are 2′,4′-fluoro nucleosides according to Formula 1001: | 10-02-2014 |
20160002281 | D-AMINO ACID COMPOUNDS FOR LIVER DISEASE - Provided herein are compounds, compositions and methods for the treatment of liver disease and conditions, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents. | 01-07-2016 |
Brian Stewart, North Reading, MA US
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20110282186 | Tracking Using Field Mapping - Methods and systems for determining the position of an object, such as tracking the position of one or more catheters in a patient's heart cavity are disclosed herein. | 11-17-2011 |
20110282187 | ELECTRODE DISPLACEMENT DETERMINATION - Methods and systems for determining whether a location of multiple current injecting electrodes has changed are disclosed herein. | 11-17-2011 |
20120184863 | ELECTROANATOMICAL MAPPING - This invention relates to the determination and/or representation of physiological information relating to a heart surface. | 07-19-2012 |
20120184864 | ELECTROANATOMICAL MAPPING - This invention relates to the determination and/or representation of physiological information relating to a heart surface. | 07-19-2012 |
20120184865 | ELECTROANATOMICAL MAPPING - This invention relates to the determination and/or representation of physiological information relating to a heart surface. | 07-19-2012 |
20130006084 | TRACKING USING FIELD MAPPING - Methods and systems for determining the position of an object, such as tracking the position of one or more catheters in a patient's heart cavity are disclosed herein. | 01-03-2013 |
20140107508 | ELECTRODE DISPLACEMENT DETERMINATION - Methods and systems for determining whether a location of multiple current injecting electrodes has changed are disclosed herein. | 04-17-2014 |
20150112178 | ELECTROANATOMICAL MAPPING - This invention relates to the determination and/or representation of physiological information relating to a heart surface. | 04-23-2015 |
20150351652 | ELECTRODE ASSEMBLY - An expandable electrode assembly for use in a cardiac mapping procedure includes multiple bipolar electrode pairs including a first electrode located on an outer surface and a second electrode located on an inner surface of the individual splines forming the expandable electrode assembly. Such an electrode arrangement may produce improved electrical activation signals which may be used to produce a more accurate map of the electrical activity of a patient's heart. | 12-10-2015 |
20160000357 | TRACKING USING FIELD MAPPING - Methods and systems for determining the position of an object, such as tracking the position of one or more catheters in a patient's heart cavity are disclosed herein. | 01-07-2016 |
20160051160 | ELECTROANATOMICAL MAPPING - This invention relates to the determination and/or representation of physiological information relating to a heart surface. | 02-25-2016 |
Brian Stewart, Burlington, MA US
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20130109945 | ELECTROANATOMICAL MAPPING | 05-02-2013 |
Diane K. Stewart, Ipswich, MA US
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20090111036 | PHOTOLITHOGRAPHY MASK REPAIR - Masks can be repaired by creating a structure that is different from the original design, but that produces the same aerial image. For example, missing opaque material can be replaced by implanting gallium atoms to reduce transmission and quartz can be etched to an appropriate depth to produce the proper phase. In another aspect, a laser or other means can be used to remove an area of a mask around a defect, and then mask structures, either the intended design structures or alternate structures that produce the same aerial image, can be constructed using charged particle beam deposition and etching. For example, an electron beam can be used to deposit quartz to alter the phase of transmitted light. An electron beam can also be used with a gas to etch quartz to remove a layer including implanted gallium atoms. Gallium staining can also be reduced or eliminated by providing a sacrificial layer that can be removed, along with the implanted gallium atoms, using, for example, a broad ion beam. In another aspect, a charged particle beam can be programmed to etch a defect using three-dimensional information derived from two charged particle beams images of the defect from different angle. | 04-30-2009 |
20090326866 | Methods and Apparatus for Statistical Characterization of Nano-Particles - A method and apparatus for determining statistical characteristics of nano-particles includes distributing the nano-particles over a surface and then determining properties of the nano-particles by automatic measurement of multiple particles or by a measurement that determines properties of multiple particles at one time, without manipulating individual nano-particles. | 12-31-2009 |
Edward J. Stewart, Winchester, MA US
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20100028297 | COADMINISTRATION OF ALPHA-FETOPROTEIN AND AN IMMUNOMODULATORY AGENT TO TREAT MULTIPLE SCLEROSIS - The present invention features methods for treating multiple sclerosis by administering an alpha-fetoprotein polypeptide (or a biologically active fragment, derivative, or analog thereof) and one or more immunomodulatory agents to a patient in need thereof. Also disclosed are compositions and kits that contain an alpha-fetoprotein polypeptide (or a biologically active fragment, derivative, or analog thereof) and one or more immunomodulatory agents. | 02-04-2010 |
20100150915 | METHODS OF TREATING MULTIPLE SCLEROSIS BY ADMINISTRATION OF ALPHA-FETOPROTEIN IN COMBINATION WITH AN INTEGRIN ANTAGONIST - The present invention relates to methods for treating multiple sclerosis by administering therapeutically effective amounts of an alpha-fetoprotein polypeptide (or a biologically active fragment, derivative, or analog thereof) and an integrin antagonist (e.g., natalizumab) to a patient in need thereof. Also disclosed are compositions and kits that comprise therapeutically effective amounts of an alpha-fetoprotein polypeptide (or a biologically active fragment, derivative, or analog thereof) and an integrin antagonist (e.g., natalizumab). | 06-17-2010 |
20100234277 | COADMINISTRATION OF ALPHA-FETOPROTEIN AND A DISEASE MODIFYING ANTI-RHEUMATIC DRUG FOR TREATING INFLAMMATORY ARTHRITIC DISEASE - The present invention relates to methods for treating an anti-inflammatory arthritic disease by coadministering therapeutically effective amounts of an alpha-fetoprotein (or a biologically active fragment thereof) and a disease modifying anti-rheumatic drug (DMARD) to a patient in need thereof. Also disclosed are compositions and kits that include therapeutically effective amounts of an alpha-fetoprotein (or a biologically active fragment thereof) and a DMARD. | 09-16-2010 |
20120087934 | COADMINISTRATION OF ALPHA-FETOPROTEIN AND AN IMMUNOMODULATORY AGENT TO TREAT MULTIPLE SCLEROSIS - The present invention features methods for treating multiple sclerosis by administering an alpha-fetoprotein polypeptide (or a biologically active fragment, derivative, or analog thereof) and one or more immunomodulatory agents to a patient in need thereof. Also disclosed are compositions and kits that contain an alpha-fetoprotein polypeptide (or a biologically active fragment, derivative, or analog thereof) and one or more immunomodulatory agents. | 04-12-2012 |
Eric Stewart, Swampscott, MA US
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20140199372 | MICROBIAL GROWTH FACTORS - Disclosed are methods of cultivating or isolating a microorganism using one or more quinones as growth factors. Also disclosed are methods of treating a mammalian species with deficiency in symbionts using such compounds. | 07-17-2014 |
Fiona Stewart, Ipswich, MA US
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20120252009 | Methods and Compositions for Enriching Either Target Polynucleotides or Non-Target Polynucleotides from a Mixture of Target and Non-Target Polynucleotides - Compositions and methods are provided for enriching non-target polynucleotides from a mixture of non-target and target polynucleotides where differences between the target polynucleotides and the non-target polynucleotides include the extent of modified bases that are present in a greater density in the target polynucleotides than in the non-target polynucleotides. This permits the target polynucleotides to be selectively and rapidly bound to an affinity matrix such as affinity protein-coated magnetic beads providing enrichment of the non-target polynucleotides in the supernatant. One use of this enrichment is to remove human genomic DNA from a mixture of DNAs obtained from human tissue samples to enrich for polynucleotides in a microbiome so as to characterize the microbiome by DNA sequencing. | 10-04-2012 |
20130189674 | Methods and Compositions for Enriching Either Target Polynucleotides or Non-Target Polynucleotides from a Mixture of Target and Non-Target Polynucleotides - Compositions and methods are provided for enriching mitochondrial DNA and optionally chloroplast DNA from eukaryotic cells in a simple rapid method that provides greater than 100 fold enrichment. Affinity protein-coated substrate in a buffer is used to efficiently bind chromosomal DNA and thereby remove it from the buffer. Mitochondrial sequencing reads reveal that non-biased sequence selection providing representation of a substantial proportion of mitochondrial DNA in the eukaryotic cells analyzed. | 07-25-2013 |
James Stewart, Newton, MA US
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20150356138 | DATASTORE MECHANISM FOR MANAGING OUT-OF-MEMORY DATA - According to some embodiments, a method for making input data available for processing by one or more processors comprises storing one or more parameters, wherein the one or more parameters comprise information identifying a location of the input data; and creating a datastore object using the one or more parameters, wherein the datastore object interfaces the input data and includes a read method for reading a chunk, the chunk being a subset of the input data, and having a size that does not exceed a memory size assigned to the one or more processors. According to some embodiments, the one or more parameters further comprise one or more of a type of the input data; a format of the input data; an offset for reading from the input data; a size of the chunk; a condition for determining the chunk; and a query for deriving the input data. | 12-10-2015 |
20150356157 | UNIFIED MAPREDUCE FRAMEWORK FOR LARGE-SCALE DATA PROCESSING - According to some embodiments, a method for processing input data comprises creating a MapReducer object corresponding to a MapReduce environment; and receiving, by a MapReduce interface, a plurality of input parameters comprising the input data; a mapper function; a reducer function; and the MapReducer object; and using the MapReduce interface to process the input data by one or more processors in the MapReduce environment using the mapper function and the reducer function. According to some embodiments, the method further comprises creating a second MapReducer object, wherein the second MapReducer object corresponds to a second MapReduce environment; receiving, by the MapReduce interface, the second MapReducer object in place of the first MapReducer object; and utilizing the MapReduce interface to process the input data by the one or more processors in the second MapReduce environment using the mapper function and the reducer function. | 12-10-2015 |
Jeff Stewart, Plainville, MA US
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20140277606 | PROCESS VARIABLE TRANSMITTER - A process variable transmitter provides an output representing a process variable. The process variable transmitter includes a process variable sensor that provides an analog sensor signal representing a process variable, an analog to digital converter that receives the analog sensor signal from the process variable sensor and converts it to digital sensor signal values, and a compensation processor. The compensation processor calculates, in a first mode, a compensated process variable value at a first slow rate. The compensation processor calculates a compensation factor relating the compensated process variable value to an initial digital sensor signal value. The compensation processor calculates, in a second mode, a process variable estimate as a function of an updated digital sensor signal value and the compensation factor. The process variable estimate is calculated at a second rate faster than the slow rate. | 09-18-2014 |
Kevin Randall Stewart, Niskayuna, MA US
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20090041984 | Structured Smudge-Resistant Coatings and Methods of Making and Using the Same - The present invention is directed to smudge-resistant coatings, methods to prepare the coatings, and products prepared by the methods. | 02-12-2009 |
20110171430 | MICROADHESIVE SYSTEMS AND METHODS OF MAKING AND USING THE SAME - The present invention is directed to adhesive systems and methods of making and using such systems. Exemplary adhesive systems comprise protrusions and/or grooves that can interleave to form a reversible adhesive interaction. | 07-14-2011 |
20130266762 | Structured Smudge-Resistant Coatings and Methods of Making and Using the Same - The present invention is directed to smudge-resistant coatings, methods to prepare the coatings, and products prepared by the methods. | 10-10-2013 |
20150284613 | MicroAdhesive Systems and Methods of Making and Using the Same - The present invention is directed to adhesive systems and methods of making and using such systems. Exemplary adhesive systems comprise protrusions and/or grooves that can interleave to form a reversible adhesive interaction. | 10-08-2015 |
Kirk W. Stewart, Woburn, MA US
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20140128689 | JOINT SENSOR DEVICES AND METHODS - Joint sensor devices, bracing members, and methods of use are provided. A joint sensor device includes a bracing member contoured to fit over a joint on a limb of a human subject, such that the bracing member allows the limb to pivot; at least a first sensor operably connected to the bracing member, such that the first sensor is configured to detect an angle of the joint; at least a second sensor operably connected to the bracing member, such that the second sensor is configured to detect a vibration caused by joint movement; and a data communication device operably connected to the sensors, wherein the data communication device communicates signals from the sensors to an external device. The devices can also include temperature sensors. Bracing members and methods of monitoring joint health of subjects are also disclosed. | 05-08-2014 |
Larry C. Stewart, Burlington, MA US
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20090307143 | Electronic Commerce System - An electronic commerce system includes a client computer and a server computer interconnected by a public packet switched communications network. The client computer is programmed to transmit to the server computer an order acceptance request that includes a plurality of terms or conditions of a proposed offer for a purchase, including multiple options of at least one of the terms or conditions of the offer. The server computer is programmed to process the order acceptance request based on pre-programmed criteria and, based on the processing of the order acceptance request, to transmit to the client computer an order acceptance response that includes a plurality of amendments to the proposed offer for the purchase, including selection of an option of the at least one of the terms or conditions. The processing of the order acceptance request is performed by a controller module that handles processing of the order acceptance request that is primarily not specific to a particular application of the electronic commerce system to which the order acceptance request pertains, and that initiates a plurality of calls to a plurality of plug-in modules. The server can handle fraud-avoidance processing of the order acceptance request. The server can initiate a call to a database of a virtual warehouse in which merchants store virtual inventories of items, to ensure that a sufficient virtual inventory exists for a purchase. | 12-10-2009 |
Lawrence C. Stewart, Burlington, MA US
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20080201344 | INTERNET SERVER ACCESS CONTROL AND MONITORING SYSTEMS - This invention relates to methods for controlling and monitoring access to network servers. In particular, the process described in the invention includes client-server sessions over the Internet. In this environment, when the user attempts to access an access-controlled file, the server subjects the request to a secondary server which determines whether the client has an authorization or valid account. Upon such verification, the user is provided with a session identification which allows the user to access to the requested file as well as any other files within the present protection domain. | 08-21-2008 |
Lawrence Colm Stewart, Wayland, MA US
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20140281837 | ERROR-CORRECTING CODE - A method is provided to transmit an error-correcting code. The method includes receiving a source packet, advancing a sliding encoder window after receiving the source packet, and generating coded packets by, when the padded packet is encoded for a first time, encoding the source packet alone, and, when the source packet is encoded for a number of times after the first time, encoding the source packet with older source packets in the sliding window. | 09-18-2014 |
Lisa Ellen Stewart, Cambridge, MA US
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20120124099 | Expert system for subject pool selection - This invention is a method directed to the recruitment and assembly of groups that are characteristic of selected populations, specifically to the identification of representative subject pools that satisfy the disparate statistical and data security needs of diverse disciplines. | 05-17-2012 |
Matthew Stewart, Somerville, MA US
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20130182328 | Structured Smudge-Resistant Anti-Reflective Coatings and Methods of Making and Using the Same - The present invention is directed to articles comprising smudge-resistant anti-reflective surfaces, and products and devices comprising the articles. | 07-18-2013 |
Michelle Stewart, Brookline, MA US
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20100190774 | INHIBITORS OF C-MET AND USES THEREOF - The present invention provides compounds useful as inhibitors of c-Met tyrosine kinase. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various proliferative disorders. | 07-29-2010 |
20110118255 | PYRAZOLO[1,5-a]PYRIMIDINES USEFUL AS JAK2 INHIBITORS - The present invention relates to compounds of formula (I) useful as selective inhibitors of JAK2 kinase. The invention also provides pharmaceutical acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various diseases, conditions or disorders. The invention also provides processes for preparing the compounds of the invention. | 05-19-2011 |
Michelle L. Stewart, Brookline, MA US
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20120172285 | METHODS AND COMPOSITIONS FOR SPECIFIC MODULATION OF MCL-1 - A series of stapled BCL-2 family peptide helices were identified as able to target the survival protein MCL-I with high affinity and a subset with unprecedented selectivity. Agents and methods for selective pharmacologic neutralization of MCL-I are provided for drug discovery and therapeutic uses, including use in overcoming the apoptotic resistance of cancer and other diseases associated with impaired cell death. | 07-05-2012 |
20130035304 | SMALL MOLECULES FOR THE MODULATION OF MCL-1 AND METHODS OF MODULATING CELL DEATH, CELL DIVISION, CELL DIFFERENTIATION AND METHODS OF TREATING DISORDERS - This invention relates to compounds which selectively bind to the survival protein MCL-1 with high affinity and selectivity, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for modulating MCL-1 activity and for treating hyperproliferative disorders, angiogenesis disorders, cell cycle regulation disorders, autophagy regulation disorders, inflammatory disorders, and/or infectious disorders and/or for enhancing cellular engraftment and/or wound repair, as a sole agent or in combination with other active ingredients. | 02-07-2013 |
20150246955 | METHODS AND COMPOSITIONS FOR SPECIFIC MODULATION OF MCL-1 - A series of stapled BCL-2 family peptide helices were identified as able to target the survival protein MCL-I with high affinity and a subset with unprecedented selectivity. Agents and methods for selective pharmacologic neutralization of MCL-I are provided for drug discovery and therapeutic uses, including use in overcoming the apoptotic resistance of cancer and other diseases associated with impaired cell death. | 09-03-2015 |
20150315211 | SMALL MOLECULES FOR THE MODULATION OF MCL-1 AND METHODS OF MODULATING CELL DEATH, CELL DIVISION, CELL DIFFERENTIATION AND METHODS OF TREATING DISORDERS - This invention relates to compounds which selectively bind to the survival protein MCL-1 with high affinity and selectivity, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for modulating MCL-1 activity and for treating hyperproliferative disorders, angiogenesis disorders, cell cycle regulation disorders, autophagy regulation disorders, inflammatory disorders, and/or infectious disorders and/or for enhancing cellular engraftment and/or wound repair, as a sole agent or in combination with other active ingredients. | 11-05-2015 |
20160031959 | BH4 STABILIZED PEPTIDES AND USES THEREOF - Provided herein are polypeptides containing stabilized BH4 domains of BCL-2 family proteins that are capable of binding and/or inactivating and/or modulating BAX protein, and/or its close homologues BAK and BOK, and/or other physiological BH4 targets. Also provided are compositions containing these polypeptides and methods of treating cytotoxic diseases that include administering to a subject one of the polypeptides. | 02-04-2016 |
Nicole Stewart, Auburn, MA US
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20110320019 | DATA MINING SYSTEM - A data mining system and method retrieve data related to an item from a database. A survey is generated for presentation in a game. The survey includes the retrieved item data and solicits from a user input data pertaining to the retrieved item data. The input data is received from the survey and stored in a database with the item data. The input data is transmitted to the game and incorporated into the game such that the user interacts with the input data as part of playing the game. | 12-29-2011 |
Richard Stewart, Boston, MA US
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20130287038 | SYNCHRONIZATION OF TRAFFIC MULTIPLEXING IN LINK AGGREGATION - Synchronization of traffic multiplexing in link aggregation is described. In an embodiment, a first link aggregator and a second link aggregator are associated with a plurality of links. The first link aggregator maintains an identifier for each link indicating at least a state of enabled or disabled. A synchronized clock is established between the first link aggregator and the second link aggregator. A particular link of the plurality of links is transitioned. Wherein, the transitioning is performed by the first link aggregator sending, to the second link aggregator, a first message identifying a particular time to transition the particular link. The first link aggregator receives, from the second link aggregator, a second message indicating that the particular time is acceptable. In response to a determination that the second message indicates that the particular time is acceptable and that the synchronized clock has reached the particular time, transitioning the link. | 10-31-2013 |
20160112549 | SYNCHRONIZATION OF TRAFFIC MULTIPLEXING IN LINK AGGREGATION - Synchronization of traffic multiplexing in link aggregation is described. In an embodiment, a first link aggregator and a second link aggregator are associated with a plurality of links. The first link aggregator maintains an identifier for each link indicating at least a state of enabled or disabled. A synchronized clock is established between the first link aggregator and the second link aggregator. A particular link of the plurality of links is transitioned. Wherein, the transitioning is performed by the first link aggregator sending, to the second link aggregator, a first message identifying a particular time to transition the particular link. The first link aggregator receives, from the second link aggregator, a second message indicating that the particular time is acceptable. In response to a determination that the second message indicates that the particular time is acceptable and that the synchronized clock has reached the particular time, transitioning the link. | 04-21-2016 |
Richard Stewart, Beverly, MA US
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20120182885 | Testing Connectivity in Networks Using Overlay Transport Virtualization - Techniques are provided for detecting connectivity failures within an OTV network using CFM. In an embodiment, a method and apparatus for using E-OAM to accurately test connectivity in an OTV network is provided. In an embodiment, one method comprises: in a first edge router that is in a local area network (LAN) and that is coupled to a core network: maintaining, for each node of the LAN, a mapping of a source address to one or more delivery multicast groups, each delivery multicast group comprising a set of other edge routers, each of the other edge routers having a connection to a distinct LAN; receiving a frame from a particular source node of a particular source address; sending the frame to a plurality of the delivery multicast groups that are mapped, in the mapping, to the particular source address. | 07-19-2012 |
Sean Stewart, Framingham, MA US
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20120098184 | SYSTEM AND METHOD FOR INLINE CUTTING AND STACKING OF SHEETS FOR FORMATION OF BOOKS - This invention provides a system and method for aligning, feeding, trimming, slitting, rotating, cross-slitting and stacking sheets, each containing one or more discrete page images thereon that allows for greater automation of the overall process so that reduced or no manual intervention is required to generate completed book stacks or “blocks” from a stream or stack of printed sheets. Sheets are fed to a first, upstream trimming station to remove margin edges and optionally separate the sheets relative to the discrete page images. The sheets are then rotated 90 degrees and fed to a second, downstream trimming station that trims the right-angle edges and optionally separates the sheets into a final group of full-bleed pages, removing margins and gutter strips. The sheets are fed to a stacking assembly to be tacked in page order and any rejected, defective sheets or stacks are removed from the order. | 04-26-2012 |
Sean Stewart, Brighton, MA US
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20100090395 | SYSTEM AND METHOD FOR ROTATING SHEETS - This invention provides a system and method for rotating sheets (a sheet rotator) receiving cut sheets from a source and providing them to a utilization device. The rotator continually engages sheets with at least one drive or rotation component throughout the transport and rotation process. The rotator includes a transport mechanism having a plurality of nip roller pairs along the length of a feed table. The nip rollers (nips) can be selectively engaged with, and disengaged from, the driven rollers using discrete actuators. This allows for feed velocity differentials when entering and exiting the rotator feed table, and also for clearance during sheet rotation. A rotator disk assembly is centered on the table between, and comprises a driven rotator disk and an overriding, freely rotating pressure disk. When sheets enter or pass through the rotator section, the pressure disk is raised to provide a clearance for sheets to pass. Sheets are rotated by lowering the pressure disk and raising surrounding nips to provide clearance for the disk to turn at least 90 degrees. Nips can then be lowered to drive the rotated sheet downstream to the outfeed end of the feed table. | 04-15-2010 |
20120080837 | SYSTEM AND METHOD FOR ROTATING SHEETS - This invention provides a system and method for rotating sheets, receiving cut sheets and providing them to a utilization device. The rotator continually engages sheets with a drive or rotation component throughout the transport and rotation process. The rotator includes a transport mechanism having nip roller pairs. The nip rollers can be engaged with, and disengaged from, the driven rollers. This allows for feed velocity differentials when entering and exiting the rotator feed table, and for clearance during sheet rotation. A rotator disk assembly is centered on the table, and comprises a driven rotator disk and an overriding, pressure disk. When sheets enter or pass through the rotator section, the pressure disk is raised to provide a clearance. Sheets are rotated by lowering the pressure disk and raising surrounding nips to provide clearance for the disk to turn. Nips can then be lowered to drive the rotated sheet downstream. | 04-05-2012 |
Sheryl L. Stewart, Stoughton, MA US
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20110261144 | ROUTING AND QUEUING INFORMATION FOR VIDEO CONFERENCING IN BANKING CENTERS - Embodiments of the present invention provide apparatuses and methods for providing improved customer service and sales experiences through collaborative face-to-face interaction between a customer and an expert in another location. Some embodiments of the invention comprise apparatuses and methods for video collaboration between an associate of the business located on-site at the point of inquiry, the customer who requires customer service, and an expert located off-site, typically at a call center. Other embodiments of the invention comprise apparatuses and methods for queuing video collaboration and non-video collaboration calls within a call center. The embodiments of the invention relate to apparatuses and methods that can be used for any business that has on-site point of inquiry centers, but the apparatuses and methods are particularly useful for banking customers who enter banking centers to interact on a face-to-face basis with an expert in the area of the customer's needs. | 10-27-2011 |
20110261947 | VIDEO COLLABORATION CALL CENTER QUEUING - Embodiments of the present invention provide apparatuses and methods for providing improved customer service and sales experiences through collaborative face-to-face interaction between a customer and an expert in another location. Some embodiments of the invention comprise apparatuses and methods for video collaboration between an associate of the business located on-site at the point of inquiry, the customer who requires customer service, and an expert located off-site, typically at a call center. Other embodiments of the invention comprise apparatuses and methods for queuing video collaboration and non-video collaboration calls within a call center. The embodiments of the invention relate to apparatuses and methods that can be used for any business that has on-site point of inquiry centers, but the apparatuses and methods are particularly useful for banking customers who enter banking centers to interact on a face-to-face basis with an expert in the area of the customer's needs. | 10-27-2011 |
William Stewart, Stoughton, MA US
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20150342143 | IN-HOME PET FEEDING AND MONITORING SYSTEM - Pets require regular and controlled amounts of food and water for their best health. A single entry feeding zone ensures that only one pet can feed at a time. The single entry feeding zone contains a food bowl into which food may be dispensed. A sensor determines which pet is currently present and denies access to food if no authorized pet is present. A detection mechanism determines the amount of food each identified pet has consumed in order to manage pet diet and denies access to food if the pet has consumed the allotted amount of food. Network functionality provides remote data tracking, correlates pet feeding behavior across multiple feeders if present, and allows a pet owner to remotely adjust parameters of the feeder or view the pet through a camera. | 12-03-2015 |
William C. Stewart, Ipswich, MA US
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20090020657 | SYSTEMS AND METHODS FOR A CONTAINER FACILITATING THE USE AND REUSE OF HANDLED BAGS - In embodiments of the present invention, a container may comprise a receptacle portion dimensioned to receive a handled bag and at least one handle flange disposed on a top edge of the receptacle to provide a holding fixture for a handle of the handled bag and to facilitate opening the bag, wherein the at least one handle flange flexes to engage a handle opening of the handled bag. | 01-22-2009 |