Eric Olson
Eric Olson, Dallas, TX US
Patent application number | Description | Published |
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20090076103 | STEM CELL DIFFERENTIATING AGENTS AND USES THEREFOR - The present invention relates to screens for compounds that can induce stem cell differentiation. In addition, isoxazoles and sulfonyl hydrazones are identified as general classes of compounds that can induce differentiation of stem cells into cells of neuronal and cardiac fate, respectively. | 03-19-2009 |
20090226375 | MICRO-RNAs THAT MODULATE SMOOTH MUSCLE PROLIFERATION AND DIFFERENTIATION AND USES THEREOF - The present invention relates to the identification of microRNAs that regulate smooth muscle cell proliferation and differentiation, including the miR-143/miR-145 cluster. Methods of treating restenosis and neointima formation by increasing expression of miR-143 and/or miR-145 are disclosed. The present invention also relates to the identification of two microRNAs, miR-486 and miR-422a, that regulate cell survival in the heart. Methods of treating or preventing cardiac hypertrophy, heart failure, or myocardial infarction by increasing expression of miR-486 and/or miR-422a in heart tissue are also disclosed. | 09-10-2009 |
20090246136 | IDENTIFICATION OF MICRO-RNAS INVOLVED IN NEUROMUSCULAR SYNAPSE MAINTENANCE AND REGENERATION - The present invention relates to the identification of miRNAs that are involved in the process of neuromuscular synaptic maintenance and regeneration following injury or disease. Modulation of these miRNAs is proposed as treatment for spinal cord injury and neurodegenerative disease. | 10-01-2009 |
20100269183 | MICRO-RNAS THAT CONTROL MYOSIN EXPRESSION AND MYOFIBER IDENTITY - The present invention relates to the identification of two microRNAs, miR-499 and miR-208b, that repress fast skeletal muscle contractile protein genes. Expression of miR-499 and/or miR-208b can be used to repress fast fiber genes and activate slow fiber genes in the treatment of musculoskeletal disorders. Inhibition of miR-499 and/or miR-208b is proposed as a treatment for cardiac hypertrophy, myocardial infarction, and/or heart failure. Pharmaceutical compositions comprising antagonists and agonists of miR-499 and miR-208b function are also disclosed. | 10-21-2010 |
20100285073 | A MICRO-RNA FAMILY THAT MODULATES FIBROSIS AND USES THEREOF - The present invention relates to the identification of a microRNA family, designated miR-29a-c, that is a key regulator of fibrosis in cardiac tissue. The inventors show that members of the miR-29 family are down-regulated in the heart tissue in response to stress, and are up-regulated in heart tissue of mice that are resistant to both stress and fibrosis. Also provided are methods of modulating expression and activity of the miR-29 family of miRNAs as a treatment for fibrotic disease, including cardiac hypertrophy, skeletal muscle fibrosis other fibrosis related diseases and collagen loss-related disease. | 11-11-2010 |
20100317713 | MICRO-RNAS OF THE MIR-15 FAMILY MODULATE CARDIOMYOCYTE SURVIVAL AND CARDIAC REPAIR - A family of microRNAs, called the miR-15 family, which includes miR-195, are shown to be up-regulated during pathological cardiac remodeling and repress the expression of mRNAs required for cell proliferation and survival, with consequent loss of cardiomyocytes. Strategies to block expression of the miR-15 family in the heart as a treatment for diverse cardiac disease are provided. | 12-16-2010 |
20110171196 | METHODS OF TREATMENT AND USES FOR CAMKII AND ITS INTERACTION WITH HDACS AND CALPAIN - The present invention provides for methods of treating and cardiac hypertrophy, heart failure, dilated cardiomyopathy or hypertension comprising the use of CaMKII-HDAC binding domains. The present invention discloses not only the fact that CaMKII binds to HDAC4 at a specific site, but that HDAC4 may dimerize with other HDACs. Both events can lead to export of HDACs from the nucleus to the cytoplasm, an event associated with the development of heart disease. Thus the methods of treatment and the screening methods of the present invention are novel attempts to prevent, treat or identify therapies for cardiac hypertrophy, heart failure, dilated cardiomyopathy or hypertension. | 07-14-2011 |
20110293674 | MICRO-RNAs THAT MODULATE SMOOTH MUSCLE PROLIFERATION AND DIFFERENTIATION - The present invention relates to the identification of microRNAs that regulate smooth muscle cell proliferation and differentiation, including the miR-143/miR-145 cluster. Methods of treating restenosis and neointima formation by increasing expression of miR-143 and/or miR-145 are disclosed. The present invention also relates to the identification of two microRNAs, miR-486 and miR-422a, that regulate cell survival in the heart. Methods of treating or preventing cardiac hypertrophy, heart failure, or myocardial infarction by increasing expression of miR-486 and/or miR-422a in heart tissue are also disclosed. | 12-01-2011 |
20120035243 | DUAL TARGETING OF MIR-208 AND MIR-499 IN THE TREATMENT OF CARDIAC DISORDERS - The present invention provides a method of treating or preventing cardiac disorders in a subject in need thereof by inhibiting the expression or function of both miR-499 and miR-208 in the heart cells of the subject. In particular, specific protocols for administering inhibitors of the two miRNAs that achieve efficient, long-term suppression are disclosed. In addition, the invention provides a method for treating or preventing musculoskeletal disorders in a subject in need thereof by increasing the expression or activity of both miR-208 and miR-499 in skeletal muscle cells of the subject. | 02-09-2012 |
20130030035 | IDENTIFICATION OF MICRO-RNAS INVOLVED IN NEUROMUSCULAR SYNAPSE MAINTENANCE AND REGENERATION - The present invention relates to the identification of miRNAs that are involved in the process of neuromuscular synaptic maintenance and regeneration following injury or disease. Modulation of these miRNAs is proposed as treatment for spinal cord injury and neurodegenerative disease. | 01-31-2013 |
20140303236 | CONTROL OF WHOLE BODY ENERGY HOMEOSTASIS BY MICRORNA REGULATION - The disclosure provides a method of regulating fatty acid or glucose metabolism in a cell by contacting the cell with a modulator of miR-208a and/or miR-208b activity or expression. The disclosure also provides a method of treating or preventing a metabolic disorder, such as obesity, diabetes, or metabolic syndrome, in a subject by administering to the subject an inhibitor of miR-208a and/or miR-208b activity or expression. Also provided is a method of enhancing or improving mitochondrial function and/or redox-homeostasis in a subject by administering to the subject an inhibitor of miR-208a and/or miR-208b activity or expression. | 10-09-2014 |
20150087693 | MICRO-RNAS INVOLVED IN MACULAR DEGENERATION - The present invention relates to the involvement of miR function in the development of age-related macular degeneration (AMD). It is shown that miR-23, miR-24 and/or miR-27 are involved in pathologic neovascularization in AMD, and that agonism (miR-24) and inhibition (miR23/27) of the function of these molecules blocks events contributing to development and progression of disease. | 03-26-2015 |
Eric Olson, Champaign, IL US
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20100193398 | REUSABLE SAMPLE HOLDING DEVICE PERMITTING READY LOADING OF VERY SMALL WET SAMPLES - A reusable sample-holding device for readily loading very small wet samples for observation of the samples by microscopic equipment, in particular in a vacuum environment. Embodiments may be used with a scanning electron microscope (SEM), a transmission electron microscope (TEM), an X-ray microscope, optical microscope, and the like. For observation of the sample, embodiments provide a thin-membrane window etched in the center of each of two silicon wafers abutting to contain the sample in a small uniform gap formed between the windows. This gap may be adjusted by employing spacers. Alternatively, the thickness of a film established by the fluid in which the sample is incorporated determines the gap without need of a spacer. To optimize resolution each window may have a thickness on the order of 50 nm and the gap may be on the order of 50 nm. | 08-05-2010 |
20120017415 | METHOD OF USE OF REUSABLE SAMPLE HOLDING DEVICE PERMITTING READY LOADING OF VERY SMALL WET SAMPLES - A method for using a reusable sample-holding device for readily loading very small wet samples for observation of the samples by microscopic equipment, in particular in a vacuum environment. The method may be used with a scanning electron microscope (SEM), a transmission electron microscope (TEM), an X-ray microscope, optical microscope, and the like. For observation of the sample, the method provides a thin-membrane window etched in the center of each of two silicon wafers abutting to contain the sample in a small uniform gap formed between the windows. This gap may be adjusted by employing spacers. Alternatively, the thickness of a film established by the fluid in which the sample is incorporated determines the gap without need of a spacer. To optimize resolution each window may have a thickness on the order of 50 nm and the gap may be on the order of 50 nm. | 01-26-2012 |
Eric Olson, Maplewood, MN US
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20100094281 | RADIO FREQUENCY ABLATION SERVO CATHETER AND METHOD - A system that interfaces with a workstation endocardial mapping system allows for the rapid and successful ablation of cardiac tissue. The system allows a physician to see a representation of the physical location of a catheter in a representation of an anatomic model of the patient's heart. The workstation is the primary interface with the physician. A servo catheter having pull wires and pull rings for guidance and a servo catheter control system are interfaced with the workstation. Servo catheter control software may run on the workstation. The servo catheter is coupled to an RF generator. The physician locates a site for ablation therapy and confirms the location of the catheter. Once the catheter is located at the desired ablation site, the physician activates the RF generator to deliver the therapy. | 04-15-2010 |
20120303013 | RADIO FREQUENCY ABLATION SERVO CATHETER AND METHOD - A system that interfaces with a workstation endocardial mapping system allows for the rapid and successful ablation of cardiac tissue. The system allows a physician to see a representation of the physical location of a catheter in a representation of an anatomic model of the patient's heart. The workstation is the primary interface with the physician. A servo catheter having pull wires and pull rings for guidance and a servo catheter control system are interfaced with the workstation. Servo catheter control software may run on the workstation. The servo catheter is coupled to an RF generator. The physician locates a site for ablation therapy and confirms the location of the catheter. Once the catheter is located at the desired ablation site, the physician activates the RF generator to deliver the therapy. | 11-29-2012 |
Eric Olson, Alexandria, VA US
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20090327487 | METHOD AND SYSTEM FOR DISCOVERING DNS RESOLVERS - A system and method for proactively discovering DNS resolvers in a network, comprising: sending IP addresses in the network to a scanning application; directing the scanning application to query each computer that corresponds to each IP address for information indicating whether each computer is a DNS resolver or a non DNS resolver; and identifying each computer as a DNS resolver or a non DNS resolver based on the information. | 12-31-2009 |
Eric Olson, Los Angeles, CA US
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20090198163 | Traction apparatus and methods - A brace and traction device and associated methods of operation. In one embodiment, the device incorporates a forwardly open head and jaw brace which is adjustably supported vertically above a forwardly collar member. The brace and the collar member are adapted such that the brace is able to mate with the collar member while still being able to rotate to the subject's left and right while remaining planar to the collar member. Adjustment may be accomplished for example manually or via an electronic motor controlled by a control mechanism and microprocessor. The microprocessor may be adapted to store information regarding a user's sessions, and facilitate communication with patient and physician personal devices, thus sending these data from recorded sessions. The processor element may also be adapted to implement therapy sessions based on physician-entered program specifications, or based on pre-programmed specifications. | 08-06-2009 |
20150157487 | TRACTION APPARATUS AND METHODS - A brace and traction device and associated methods of operation. In one embodiment, the device incorporates a forwardly open head and jaw brace which is adjustably supported vertically above a forwardly collar member. The brace and the collar member are adapted such that the brace is able to mate with the collar member while still being able to rotate to the subject's left and right while remaining planar to the collar member. Adjustment may be accomplished for example manually or via an electronic motor controlled by a control mechanism and microprocessor. The microprocessor may be adapted to store information regarding a user's sessions, and facilitate communication with patient and physician personal devices, thus sending these data from recorded sessions. The processor element may also be adapted to implement therapy sessions based on physician-entered program specifications, or based on pre-programmed specifications. | 06-11-2015 |
Eric Olson, Belmont, MA US
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20080287546 | Quorum Sensing Modulators - Compounds described herein are useful in modulating bacterial quorum sensing. | 11-20-2008 |
20090123512 | Quorum Sensing Modulators - Compounds described herein are useful in modulating bacterial quorum sensing. | 05-14-2009 |
Eric Olson, Cave Creek, AZ US
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20080303957 | Modular Entertainment and Data System - A modular, reconfigurable entertainment and data system provides data to at least one user. A cabinet is provided which contains a plurality of module receiving rails therein. A power supply module is positioned on a first one of the rails and provides an operating potential. An entertainment/data module is positioned on a second rail and a control module is positioned on a third one of the module receiving rails and provides an interface between the user and the entertainment/data module. | 12-11-2008 |
Eric Olson, Orlando, FL US
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20080289830 | Roof-top fire prevention sprinkler system with storage rack - A roof-top fire prevention sprinkler system, with or without an optional, separate storage rack, is comprised of a rotating sprinkler head mounted on a support frame of conduit having fluid communication between a water source and the sprinkler head. The frame, having a more or less rectangular shape bent in the middle of the long sides, saddles the peak of a roof to be protected. At the bend in the frame, at the roof peak, a cross piece of conduit bisects the long sides of the rectangle, and is in fluid communication therewith. The sprinkler head is connected to the middle of the cross piece. Water can be supplied through a garden hose connected to a pipe extension of stiff conduit which is in turn connected to one of the short sides of the rectangle. The pipe extension can act as a pole to place or retrieve the support frame at or from the roof peak without the user having to climb onto the roof. Cylindrical pliant rollers surrounding the short sides of the rectangle allow the frame to glide easily up a sloping side of a pitched roof. The optional storage rack can hold the sprinkler and frame, disconnected from the pipe extension, on end against a wall, taking up little space when not in use. | 11-27-2008 |
Eric Olson, Chicago, IL US
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20140279245 | SYSTEM AND METHOD FOR BROWSING A PRODUCT CATALOG AND FOR DYNAMICALLY GENERATED PRODUCT PATHS - A mobile device such as a tablet computer accesses a server to search a product catalog. The catalog is displayed as a broad classifications of products, which when selected result in the display of sub-classifications within the classification. Levels of searching are provided to the product level, and movement within each level is possible. | 09-18-2014 |
Eric Olson, Fort Worth, TX US
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20150241328 | NON-METALLIC DEBRIS MONITORING SYSTEM - A system and method to detect particles in a fluid stream. The system includes a separator configured to separate particles from bubbles passing through the fluid stream and a sensor configured to detect the particles. The method includes passing the fluid stream through the separator, separating the particles from bubbles passing through the fluid stream, and detecting the presence of the particles. | 08-27-2015 |
Eric Olson, Thornton, CO US
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20150354218 | ROOFING MEMBRANES HAVING MULTIPLE ADHESIVE REGIONS AND METHOD THEREFOR - A roofing membrane may include a main body, a first material, and a second material. The first material may be bonded to the main body and positioned toward a first edge thereof. The second material may be bonded to the main body and positioned toward a second edge thereof. The second edge may be positioned opposite the first edge such that the first and second materials are positioned toward opposite edges of the main body. At least one of the first material or the second material may include a first reactive material of a chemically reactive two-part cure system that is configured to chemically react upon contact of the first reactive material with a second reactive material of the chemically reactive two-part cure system. | 12-10-2015 |
Eric Olson, Melbourne, FL US
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20160050282 | METHOD FOR EXTENDING HYBRID HIGH AVAILABILITY CLUSTER ACROSS NETWORK - Method and apparatus for switching between a first server and a second server, each located within a virtual private cloud and the first server being located within a first zone and the second server being located within a second zone that is physically separate from the first zone. The method and apparatus can be configured to determine that the first server has experienced a failure to send or receive data. The method and apparatus can be further configured to enable a second port on the second server. The method and apparatus can be further configured to create a new route table at the second server and flush the previous rout table, as well as transmit, via the second port, a request to a virtual private cloud controller to update an elastic internet protocol address with the second port information and receive data from the virtual private cloud controller. | 02-18-2016 |