Patent application number | Description | Published |
20090319582 | DATABASE SNAPSHOT MANAGEMENT - Technologies are described herein for managing database snapshots. One user interface is provided for managing the automated creation and deletion of database snapshots. Parameters are received through the user interface that define how the database snapshots should be created and deleted. Once the parameters are defined, a timer job is executed that causes a DBMS to create and delete the database snapshots according to the specified parameters. A user interface is also provided for manually managing the creation, deletion, and restoration of database snapshots. A request may be received through this user interface to recover data from a database snapshot. In response to such a request, another user interface is provided for specifying the data that should be recovered. Once the data to be recovered has been specified, the desired data is recovered from the database snapshot. | 12-24-2009 |
20100192193 | SECURITY RESTRICTION TECHNIQUES FOR BROWSER-BASED APPLICATIONS - Various technologies and techniques are disclosed for restricting security levels that can be used with browser-based applications. When a request is received from an external application to retrieve data for use in a client browser, an intersection is performed on a permission set of a user of the client browser and of the external application to determine a new permission set to use for retrieving the requested data. Techniques for restricting operations of an external application that is being run in a client browser are also described. A session token is returned to a client browser after validating access can be granted to the client browser. Validation is performed to confirm access can be granted to an external application. A request for data is received from the external application, with the request for data containing the session token. The requested data is retrieved and returned to the external application. | 07-29-2010 |
20100281049 | EXPLORING ATTACHED AND UNATTACHED CONTENT DATABASES - Various technologies and techniques are disclosed for searching for and extracting data from databases of content management applications. User input is received to connect to a database or database snapshot of an application, and a connection is established. When the database is not part of a current live instance of the application, an emulation is performed such that the database is treated like it is attached to the current live instance of the application. The user is able to browse and/or search for content, including documents, in the database or database snapshot without having to explore individual site collection structure and user interfaces of individual sites. A site collection user interface (UI), a site selector UI, and/or a list selector UI, for example, provide data entry fields for entering search requirements. Unattached databases can be managed using commands, such as using an object model or command line. | 11-04-2010 |
Patent application number | Description | Published |
20090083835 | NETWORK ACCESS CONTROL - An system for controlling access to a network by a user device. The system includes a criteria engine that generates a plurality of criteria to be monitored on the user device and a checker that generates at least one check for each of the plurality of criteria. The system further includes a profiler that retrieves a profile for the user device, the profile including the plurality of criteria and the at least one check for each of the plurality of criteria, a comparator that compares a summary of the retrieved profile to a summary of a profile received from the user device and a communicator that communicates a message to the user device based on the comparison. | 03-26-2009 |
20090307522 | COMMUNICATIONS PATH STATUS DETECTION SYSTEM - A network failover apparatus and method for use in a client-server system. The method includes establishing at least a first and further path between a client and a server. The first path connects the server to the client through a first network and a first interface of the client and the further path connects the server to the client through a further network that is separate from the first network and a further interface of the client. The method also includes reaching the server through the first interface, detecting that the server is no longer reachable through the first interface, and identifying the first interface as failed. The method also includes reaching the server through the further interface after the first interface is identified as failed, testing the first interface to determine whether the server is reachable while the server is reachable through the further interface, and reestablishing a connection to the server through the first interface. | 12-10-2009 |
20120173918 | COMMUNICATIONS PATH STATUS DETECTION SYSTEM - Virtual network interface selection manager in a client-server system, in which client and server are connectable through a plural alternate networks. System includes plural interfaces connectable to server through the plural networks, current interface indicator identifying a current interface through which data is transmitted to and/or received from the server, and prioritized listing of plural interfaces ranked in a descending order. Event detector detects occurrence of an event including time-out condition; successful interface test; and change in the plurality of interfaces, and a tester tests each plural interface in prioritized listing in a ranked order to test whether server is reachable. Marker identifies which of plural interfaces successfully pass the test, and switch switches from current interface to a higher priority interface when the marker identifies a higher priority interface as having successfully passed the test, whereby current interface indicator will identify the higher priority interface as current interface. | 07-05-2012 |
20140344035 | MANAGING CONTENT RECOMMENDATIONS FOR CUSTOMERS - Embodiments are directed towards recommending coupon templates to a customer, from which the customer can select and have published to consumers. A ranked order may be determined for the coupon templates for each of a plurality of categories. A subset of the coupon templates may be recommended and provided to a customer. The subset of coupon templates may be determined based on a category of the customer, the ranked order of the plurality of coupon templates for the category, external variables, or the like, or any combination thereof. One or more of the subset of coupon templates may be selected by the customer and published to the consumers. The ranked order of the plurality of coupon templates may be determined and/or modified based on monitored actions associated with previously published coupons, such as by employing a success of similar attributes associated with previously published coupons. | 11-20-2014 |
Patent application number | Description | Published |
20100330589 | NEEDLE ARRAY ASSEMBLY AND METHOD FOR DELIVERING THERAPEUTIC AGENTS - A fluid delivery device includes an array of needles, each in fluid communication with a respective reservoir. Respective actuators are coupled so as to be operable to drive fluid from the reservoirs via needle ports. Each needle can have a plurality of ports, and the ports can be arranged to deliver a substantially equal amount of fluid at any given location along its length. A driver is coupled to the actuators to selectively control the rate, volume, and direction of flow of fluid through the needles. The device can simultaneously deliver a plurality of fluid agents along respective axes in solid tissue in vivo. If thereafter resected, the tissue can be sectioned for evaluation of an effect of each agent on the tissue, and based on the evaluation, candidate agents selected or deselected for clinical trials or therapy, and subjects selected or deselected for clinical trials or therapeutic treatment. | 12-30-2010 |
20110230839 | Needle Array Assembly and Method for Delivering Therapeutic Agents - A fluid delivery device includes an array of needles, each in fluid communication with a respective reservoir. Respective actuators are coupled so as to be operable to drive fluid from the reservoirs via needle ports. Each needle can have a plurality of ports, and the ports can be arranged to deliver a substantially equal amount of fluid at any given location along its length. A driver is coupled to the actuators to selectively control the rate, volume, and direction of flow of fluid through the needles. The device can simultaneously deliver a plurality of fluid agents along respective axes in solid tissue in vivo. If thereafter resected, the tissue can be sectioned for evaluation of an effect of each agent on the tissue, and based on the evaluation, candidate agents selected or deselected for clinical trials or therapy, and subjects selected or deselected for clinical trials or therapeutic treatment. | 09-22-2011 |
20120087866 | NEEDLE ARRAY ASSEMBLY AND METHOD FOR DELIVERING THERAPEUTIC AGENTS - A fluid delivery device includes an array of needles, each in fluid communication with a respective reservoir. Respective actuators are coupled so as to be operable to drive fluid from the reservoirs via needle ports. Each needle can have a plurality of ports, and the ports can be arranged to deliver a substantially equal amount of fluid at any given location along its length. A driver is coupled to the actuators to selectively control the rate, volume, and direction of flow of fluid through the needles. The device can simultaneously deliver a plurality of fluid agents along respective axes in solid tissue in vivo. If thereafter resected, the tissue can be sectioned for evaluation of an effect of each agent on the tissue, and based on the evaluation, candidate agents selected or deselected for clinical trials or therapy, and subjects selected or deselected for clinical trials or therapeutic treatment. | 04-12-2012 |
20120089095 | NEEDLE ARRAY ASSEMBLY AND METHOD FOR DELIVERING THERAPEUTIC AGENTS - A fluid delivery device includes an array of needles, each in fluid communication with a respective reservoir. Respective actuators are coupled so as to be operable to drive fluid from the reservoirs via needle ports. Each needle can have a plurality of ports, and the ports can be arranged to deliver a substantially equal amount of fluid at any given location along its length. A driver is coupled to the actuators to selectively control the rate, volume, and direction of flow of fluid through the needles. The device can simultaneously deliver a plurality of fluid agents along respective axes in solid tissue in vivo. If thereafter resected, the tissue can be sectioned for evaluation of an effect of each agent on the tissue, and based on the evaluation, candidate agents selected or deselected for clinical trials or therapy, and subjects selected or deselected for clinical trials or therapeutic treatment. | 04-12-2012 |
20120094866 | NEEDLE ARRAY ASSEMBLY AND METHOD FOR DELIVERING THERAPEUTIC AGENTS - A fluid delivery device includes an array of needles, each in fluid communication with a respective reservoir. Respective actuators are coupled so as to be operable to drive fluid from the reservoirs via needle ports. Each needle can have a plurality of ports, and the ports can be arranged to deliver a substantially equal amount of fluid at any given location along its length. A driver is coupled to the actuators to selectively control the rate, volume, and direction of flow of fluid through the needles. The device can simultaneously deliver a plurality of fluid agents along respective axes in solid tissue in vivo. If thereafter resected, the tissue can be sectioned for evaluation of an effect of each agent on the tissue, and based on the evaluation, candidate agents selected or deselected for clinical trials or therapy, and subjects selected or deselected for clinical trials or therapeutic treatment. | 04-19-2012 |
20120109104 | NEEDLE ARRAY ASSEMBLY AND METHOD FOR DELIVERING THERAPEUTIC AGENTS - A fluid delivery device includes an array of needles, each in fluid communication with a respective reservoir. Respective actuators are coupled so as to be operable to drive fluid from the reservoirs via needle ports. Each needle can have a plurality of ports, and the ports can be arranged to deliver a substantially equal amount of fluid at any given location along its length. A driver is coupled to the actuators to selectively control the rate, volume, and direction of flow of fluid through the needles. The device can simultaneously deliver a plurality of fluid agents along respective axes in solid tissue in vivo. If thereafter resected, the tissue can be sectioned for evaluation of an effect of each agent on the tissue, and based on the evaluation, candidate agents selected or deselected for clinical trials or therapy, and subjects selected or deselected for clinical trials or therapeutic treatment. | 05-03-2012 |
20120121514 | NEEDLE ARRAY ASSEMBLY AND METHOD FOR DELIVERING THERAPEUTIC AGENTS - A fluid delivery device includes an array of needles, each in fluid communication with a respective reservoir. Respective actuators are coupled so as to be operable to drive fluid from the reservoirs via needle ports. Each needle can have a plurality of ports, and the ports can be arranged to deliver a substantially equal amount of fluid at any given location along its length. A driver is coupled to the actuators to selectively control the rate, volume, and direction of flow of fluid through the needles. The device can simultaneously deliver a plurality of fluid agents along respective axes in solid tissue in vivo. If thereafter resected, the tissue can be sectioned for evaluation of an effect of each agent on the tissue, and based on the evaluation, candidate agents selected or deselected for clinical trials or therapy, and subjects selected or deselected for clinical trials or therapeutic treatment. | 05-17-2012 |
20120265064 | NEEDLE ARRAY ASSEMBLY AND METHOD FOR DELIVERING THERAPEUTIC AGENTS - A fluid delivery device includes an array of needles, each in fluid communication with a respective reservoir. Respective actuators are coupled so as to be operable to drive fluid from the reservoirs via needle ports. Each needle can have a plurality of ports, and the ports can be arranged to deliver a substantially equal amount of fluid at any given location along its length. A driver is coupled to the actuators to selectively control the rate, volume, and direction of flow of liquid through the needles. The device can simultaneously deliver a plurality of fluid agents along respective axes in solid tissue in vivo. If thereafter resected, the tissue can be sectioned for evaluation of an effect of each agent on the tissue, and based on the evaluation, candidate agents selected or deselected for clinical trials or therapy, and subjects selected or deselected for clinical trials or therapeutic treatment. | 10-18-2012 |
20120296206 | NEEDLE ARRAY ASSEMBLY AND METHOD FOR DELIVERING THERAPEUTIC AGENTS - A fluid delivery device includes an array of needles, each in fluid communication with a respective reservoir. Respective actuators are coupled so as to be operable to drive fluid from the reservoirs via needle ports. Each needle can have a plurality of ports, and the ports can be arranged to deliver a substantially equal amount of fluid at any given location along its length. A driver is coupled to the actuators to selectively control the rate, volume, and direction of flow of liquid through the needles. The device can simultaneously deliver a plurality of fluid agents along respective axes in solid tissue in vivo. If thereafter resected, the tissue can be sectioned for evaluation of an effect of each agent on the tissue, and based on the evaluation, candidate agents selected or deselected for clinical trials or therapy, and subjects selected or deselected for clinical trials or therapeutic treatment. | 11-22-2012 |
20140179560 | DRUG DISCOVERY METHODS AND PLATFORMS - Methods and systems for discovering drug candidates are disclosed. Methods and systems can include generating libraries of potential drug candidates (e.g., libraries of peptides) that can be screened to identify sub-libraries of potential drug candidates (e.g., sub-libraries of peptides) having selected pharmacological properties. Methods of making and using peptide libraries are also provided. D-amino acid chlorotoxins and D-amino acid chlorotoxin variants are also provided. | 06-26-2014 |
20140241993 | FLUORESCENT CHLOROTOXIN CONJUGATE AND METHOD FOR INTRA-OPERATIVE VISUALIZATION OF CANCER - A chlorotoxin conjugate detectable by fluorescence imaging that allows for intra-operative visualization of cancerous tissues, compositions that include the chlorotoxin conjugate, and methods for using the chlorotoxin conjugate. | 08-28-2014 |
Patent application number | Description | Published |
20140162360 | NEEDLE ARRAY ASSEMBLY AND METHOD FOR DELIVERING THERAPEUTIC AGENTS - A fluid delivery device includes an array of needles, each in fluid communication with a respective reservoir. Respective actuators are coupled so as to be operable to drive fluid from the reservoirs via needle ports. Each needle can have a plurality of ports, and the ports can be arranged to deliver a substantially equal amount of fluid at any given location along its length. A driver is coupled to the actuators to selectively control the rate, volume, and direction of flow of fluid through the needles. The device can simultaneously deliver a plurality of fluid agents along respective axes in solid tissue in vivo. If thereafter resected, the tissue can be sectioned for evaluation of an effect of each agent on the tissue, and based on the evaluation, candidate agents selected or deselected for clinical trials or therapy, and subjects selected or deselected for clinical trials or therapeutic treatment. | 06-12-2014 |
20140162901 | NEEDLE ARRAY ASSEMBLY AND METHOD FOR DELIVERING THERAPEUTIC AGENTS - A fluid delivery device includes an array of needles, each in fluid communication with a respective reservoir. Respective actuators are coupled so as to be operable to drive fluid from the reservoirs via needle ports. Each needle can have a plurality of ports, and the ports can be arranged to deliver a substantially equal amount of fluid at any given location along its length. A driver is coupled to the actuators to selectively control the rate, volume, and direction of flow of fluid through the needles. The device can simultaneously deliver a plurality of fluid agents along respective axes in solid tissue in vivo. If thereafter resected, the tissue can be sectioned for evaluation of an effect of each agent on the tissue, and based on the evaluation, candidate agents selected or deselected for clinical trials or therapy, and subjects selected or deselected for clinical trials or therapeutic treatment. | 06-12-2014 |
20140309590 | NEEDLE ARRAY ASSEMBLY AND METHOD FOR DELIVERING THERAPEUTIC AGENTS - A fluid delivery device includes an array of needles, each in fluid communication with a respective reservoir. Respective actuators are coupled so as to be operable to drive fluid from the reservoirs via needle ports. Each needle can have a plurality of ports, and the ports can be arranged to deliver a substantially equal amount of fluid at any given location along its length. A driver is coupled to the actuators to selectively control the rate, volume, and direction of flow of fluid through the needles. The device can simultaneously deliver a plurality of fluid agents along respective axes in solid tissue in vivo. If thereafter resected, the tissue can be sectioned for evaluation of an effect of each agent on the tissue, and based on the evaluation, candidate agents selected or deselected for clinical trials or therapy, and subjects selected or deselected for clinical trials or therapeutic treatment. | 10-16-2014 |
Patent application number | Description | Published |
20080279780 | Fluorescent chlorotoxin conjugate and method for intra-operative visualization of cancer - A chlorotoxin conjugate detectable by fluorescence imaging that allows for intra-operative visualization of cancerous tissues, compositions that include the chlorotoxin conjugate, and methods for using the chlorotoxin conjugate. | 11-13-2008 |
20130195760 | CHLOROTOXIN VARIANTS, CONJUGATES, AND METHODS FOR THEIR USE - Chlorotoxin variants, chlorotoxin variant conjugates, compositions that include the chlorotoxin variants or conjugates, and methods for using the chlorotoxin variants, conjugates, and compositions. | 08-01-2013 |
20150025017 | COMPOSITIONS AND METHODS FOR TREATING CANCER - The present disclosure provides compositions and methods for treating cellular hyperproliferative disorders with a PHF5α inhibitor, such as siRNA, shRNA, antisense oligonucleotides, or pharmaceutical compounds. Exemplary cellular hyperproliferative disorders that can be treated with the PHF5α antagonists of the present disclosure include cancers, such as gliomas, adenocarcinomas, cervical cancer or prostate cancer. | 01-22-2015 |
Patent application number | Description | Published |
20130014047 | Tab Trimming - Various embodiments proactively monitor and efficiently manage resource usage of individual tabs. In at least some embodiments, one or more tabs can be dehydrated in accordance with various operational properties, and rehydrated when a user actually activates a particular tab. In at least some embodiments, rehydration can occur on a tab-by-tab basis, while at least some tabs remain dehydrated. Dehydrated tabs can, in some embodiments, be visually presented to a user in a manner in which normal, active tabs are presented. | 01-10-2013 |
20130031490 | ON-DEMAND TAB REHYDRATION - Various embodiments proactively monitor and efficiently manage resource usage of individual tabs. In at least some embodiments, one or more tabs can be dehydrated in accordance with various operational parameters, and rehydrated when a user actually activates a particular tab. In at least some embodiments, rehydration can occur on a tab-by-tab basis, while at least some tabs remain dehydrated. Dehydrated tabs can, in some embodiments, be visually presented to a user in a manner in which normal, active tabs are presented. | 01-31-2013 |
20130067473 | Modes for Applications - Techniques for modes for applications are described. In one or more implementations, multiple operational modes are provided for an application. The operational modes can be associated with different resource access permissions, trust statuses, graphical user interfaces, and so on. An application can be launched in a particular one of the operational modes based on a context in which a request to launch the application is received. In one or more implementations, correlations between launch request contexts for an application and operational modes can be configured to enable different launch requests to cause an application to launch into different operational modes. | 03-14-2013 |
Patent application number | Description | Published |
20120158547 | PERSONAL REMOTE STORAGE FOR PURCHASED ELECTRONIC CONTENT ITEMS - Architectures and techniques are described to provide personal remote storage space for electronic content items acquired (e.g., purchased) by a user of a client device. In some cases, as part of a transaction to acquire the electronic content item, an individual may receive an option that is selectable to indicate a preference to send electronic content items acquired by the individual to a personal remote storage space of the individual. When the option to store the electronic content item in the personal remote storage space is not selected by the individual, the electronic content item may be provided directly to a designated computing device of the individual. | 06-21-2012 |
20120239713 | VARIANTS OF FILES IN A FILE SYSTEM - Disclosed are various embodiments that provide variants of files in a file system. Multiple file systems are maintained for multiple users. Each file system includes multiple files and one or more folder. Each file includes a respective unique identifier and a respective reference to a data object stored in one or more data store. Multiple file variants are maintained. Each file variant includes the respective unique identifier of a respective file. Each file variant also includes a respective reference to a secondary data object stored in the one or more data stores. The secondary data object is related to the primary data object referenced by the respective file. | 09-20-2012 |
20120254340 | Local Storage Linked to Networked Storage System - Disclosed are various embodiments for storage of files. A portable memory device is configured to couple to a computing device, and a storage management application is stored in the portable memory device, the storage management application being executable by a processor circuit. The storage management application is configured to send a plurality of files for storage in a networked storage system, the networked storage system being remote to the computing device. The storage management system caches a subset of the files on the portable memory device and maintains a local file directory in the portable memory device. The local file directory lists the files stored in the networked storage system in association with an account linked to the portable memory device. | 10-04-2012 |
20120324040 | LOCAL NETWORKED STORAGE LINKED TO REMOTE NETWORKED STORAGE SYSTEM - Disclosed are various embodiments for local networked storage that is linked to a remote networked storage system. In a client application, it is determined whether a local networked storage system is accessible to the client through a local network. A file is sent to the local networked storage system over the local network for storage by the local networked storage system when the local networked storage system is determined to be accessible to the client through the local network. A file is sent to a remote networked storage system over a remote network for storage by the remote networked storage system in association with a user account when the local networked storage system is determined not to be accessible through the local network. | 12-20-2012 |
20140351224 | Making Publisher Content Available to Specific Users - Disclosed are various embodiments for making publisher content available to specific users. A directory describing media items that are remotely stored is presented via a user interface. Selection information corresponding to a particular media item is received via the user interface. The media item is requested and received from another computing device. Consumption data is collected during consumption of the media item. The consumption data is sent to another computing device. | 11-27-2014 |
Patent application number | Description | Published |
20090022659 | Antibodies to TNF alpha and use thereof - The present invention is directed to antibodies and fragments thereof having binding specificity for TNF-α. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the V | 01-22-2009 |
20090028784 | Antibodies to IL-6 and use thereof - The present invention is directed to antibodies and fragments thereof having binding specificity for IL-6. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the V | 01-29-2009 |
20090297513 | ANTIBODIES TO IL-6 AND USE THEREOF - The present invention is directed to antibodies and fragments thereof and humanized versions thereof having binding specificity for IL-6. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the V | 12-03-2009 |
20100129357 | ANTIBODIES TO IL-6 AND USE THEREOF - The present invention is directed to therapeutic methods using IL-6 antagonists such as an Ab1 antibody or antibody fragment having binding specificity for IL-6 to prevent or treat disease or to improve survivability or quality of life of a patient in need thereof. In preferred embodiments these patients will comprise those exhibiting (or at risk of developing) an elevated serum C-reactive protein level, reduced serum albumin level, elevated D-dimer or other cogulation cascade related protein(s), cachexia, fever, weakness and/or fatigue prior to treatment. The subject therapies also may include the administration of other actives such as chemotherapeutics, anti-coagulants, statins, and others. | 05-27-2010 |
20100150829 | Antibodies to IL-6 and use thereof - The present invention is directed to therapeutic methods using IL-6 antagonists such as an Ab1 antibody or antibody fragment having binding specificity for IL-6 to prevent or treat disease or to improve survivability or quality of life of a patient in need thereof. In preferred embodiments these patients will comprise those exhibiting (or at risk of developing) an elevated serum C-reactive protein level, reduced serum albumin level, elevated D-dimer or other coagulation cascade related protein(s), cachexia, fever, weakness and/or fatigue prior to treatment. The subject therapies also may include the administration of other actives such as chemotherapeutics, anti-coagulants, statins, and others. | 06-17-2010 |
20100290993 | Antibodies to IL-6 and use thereof - The present invention is directed to antibodies and fragments thereof having binding specificity for IL-6. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the V | 11-18-2010 |
20110293622 | ANTIBODIES TO IL-6 AND USE THEREOF - The present invention is directed to antibodies and fragments thereof and humanized versions thereof having binding specificity for IL-6. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the V | 12-01-2011 |
20120142900 | ANTIBODIES TO IL-6 AND USE THEREOF - The present invention relates to anti-IL-6 antibodies and antibody fragments having a particular epitopic specificity. These antibodies and antibody fragments have clinical therapeutic and diagnostic applications in treating and detecting disease conditions wherein Il-6 levels are elevated. | 06-07-2012 |
20120294797 | ANTI-CGRP COMPOSITIONS AND USE THEREOF - The present invention is directed to antibodies and fragments thereof having binding specificity for CGRP. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the V | 11-22-2012 |
20130017575 | Nucleic acids encoding anti-IL-6 antibodies of defined epitopic specificity - The invention relates to nucleic acids encoding antibody or antibody fragments that specifically binds to an epitope on an intact human IL-6 polypeptide, which epitope when ascertained by epitopic mapping includes one or more residues comprised in each of the following IL-6 fragments (i) a fragment consisting of amino acid residues 37-51 of human Il-6, (ii) a fragment consisting of amino acid residues 70-84 of human Il-6, (iii) a fragment consisting of amino acid residues 169-183 of human Il-6, (iv) a fragment consisting of amino acid residues 31-45 of human Il-6 and (v) a fragment consisting of amino acid residues 58-72 of human IL-6. | 01-17-2013 |
20130034554 | ANTIBODIES TO IL-6 AND USE THEREOF - The present invention is directed to therapeutic methods using IL-6 antagonists such as an Ab1 antibody or antibody fragment having binding specificity for IL-6 to prevent or treat disease or to improve survivability or quality of life of a patient in need thereof. In preferred embodiments these patients will comprise those exhibiting (or at risk of developing) an elevated serum C-reactive protein level, reduced serum albumin level, elevated D-dimer or other coagulation cascade related protein(s), cachexia, fever, weakness and/or fatigue prior to treatment. The subject therapies also may include the administration of other actives such as chemotherapeutics, anti-coagulants, statins, and others. Additional preferred embodiments of the subject invention relate to therapeutic compositions and methods treating or preventing rheumatoid arthritis, especially subcutaneous and intravenous formulations and dosage regimens using IL-6 antagonists according to the invention, as well as methods for preventing or treating GVHD or leukemia relapse in subjects receiving transplanted cells, tissue or organs, use thereof in the treatment or prevention of mucositis, and use thereof to potentiate the cytotoxic, apoptotic, and anti-metastatic or anti-invasive effects of chemotherapeutics and radiation on cancers, especially cancers that have developed a resistance to radiation or chemotherapy, such as an EGFR inhibitor. | 02-07-2013 |
20130224201 | ANTIBODIES TO IL-6 AND USE THEREOF - The present invention is directed to therapeutic methods using IL-6 antagonists such as an Ab1 antibody or antibody fragment having binding specificity for IL-6 to prevent or treat disease or to improve survivability or quality of life of a patient in need thereof. In preferred embodiments these patients will comprise those exhibiting (or at risk of developing) an elevated serum C-reactive protein level, reduced serum albumin level, elevated D-dimer or other coagulation cascade related protein(s), cachexia, fever, weakness and/or fatigue prior to treatment. The subject therapies also may include the administration of other actives such as chemotherapeutics, anti-coagulants, statins, and others. | 08-29-2013 |
20130302399 | ANTI-PCSK9 ANTIBODIES AND USE THEREOF - The present invention is directed to antibodies and fragments thereof having binding specificity for PCSK9. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the V | 11-14-2013 |
Patent application number | Description | Published |
20130144878 | DATA DISCOVERY AND DESCRIPTION SERVICE - The subject disclosure relates to one or more computer-implemented processes for collecting, analyzing, and employing annotations of data sources. In particular, an annotation component is configured to receive annotations of data for a data source, wherein the respective annotations comprise different associations of a global terms with the data of the data source, a data store configured to store the annotations, and an interface component configured to render the data based on the annotations in response to a request for the data. In an aspect, storing information, the data also stores descriptions of the data sources and definitions of the global terms, and the interface component determines a subset of the information in the data store based on the annotations. A method is further provided comprising receiving a global term and determining data sources that have the global term associated with the data thereof based on the information in the data store. | 06-06-2013 |
20130159387 | REFERENCING CHANGE(S) IN DATA UTILIZING A NETWORK RESOURCE LOCATOR - The subject disclosure relates to techniques for referencing a change in data utilizing a network resource locator. An interface component can receive one or more requests that are associated with a data set from a client, and send, based on the one or more requests, a network resource locator and at least one portion of the data set to the client. Further, a data service component can compute a parameter that is associated with a change of the data set, and include the parameter in the network resource locator. In other embodiments, the data service component can receive a request utilizing the network resource locator, determine the change of the data set based on the parameter, and send the change of the data set to the client. | 06-20-2013 |
20130159530 | REPRESENTATION/INVOCATION OF ACTIONS/FUNCTIONS IN A HYPERMEDIA-DRIVEN ENVIRONMENT - The subject disclosure relates to techniques for performing an operation on a resource, based on a state of the resource, by invoking a hypertext transfer protocol (HTTP) request on a universal resource locator (URL) indicating the operation. An interface component can receive a request including an HTTP method and a URL including a first portion indicating a resource and a second portion indicating an operation. Further, an invocation component, in response to the operation being associated with the resource, can invoke the operation on the resource utilizing the HTTP method based on a state of the resource. Other embodiments relate to conditionally returning the operation within a return payload, for example, alone or within a feed, based on an applicability of the operation according to a state of an associated resource. | 06-20-2013 |
20130159829 | PROVIDING DATA EXPERIENCE(S) VIA DISPARATE SEMANTIC ANNOTATIONS BASED ON A RESPECTIVE USER SCENARIO - The subject disclosure relates to techniques for providing data experience(s) via disparate semantic annotations based on a respective user scenario. An annotation component can synthesize semantic information for respective data types of data set(s), associate the semantic information with the respective data types to obtain respective data annotations, and in response to receiving a query from a client, send at least a portion of the respective data annotations to the client. Further, a data aggregation component can aggregate the respective data annotations and at least a portion of the data set(s). Other embodiments relate to performing, via an application, operations utilizing a data type based on respective semantic annotations associated with the data type. Yet other embodiments relate to receiving external data annotation(s) and associating the external data annotation(s) with portion(s) of the respective data types to derive portion(s) of the respective semantic annotations. | 06-20-2013 |
20130159938 | GESTURE INFERRED VOCABULARY BINDINGS - The subject disclosure relates to annotating data based on gestures. Gestures include user interaction with a client device or client software. Gestures are tracked and associated with data. In an aspect, client context associated with a gesture is also tracked. The gestures are then employed to determine a global term to associate with the data. In an aspect, a look-up table comprising a pre-defined relationship between gestures and a global term can be employed. In another aspect, an inference component employ context information in conjunction with the tracked gestures to determine a global term to assign to data. After a global term is determined for data based on a gesture, an annotation file for the data can be created associating the data with the global term. | 06-20-2013 |
Patent application number | Description | Published |
20090282475 | Media Streams from Containers Processed by Hosted Code - Described is a technology by which code, such as an untrusted web application hosted in a browser, provides content through an interface for playback by an application environment, such as an application environment running in a browser plug-in. Content may be in the form of elementary video, audio and/or script streams. The content is in a container that is unpackaged by the application code, whereby the content may be packaged in any format that the application understands, and/or or come from any source from which the application can download the container. An application environment component such as a platform-level media element receives information from an application that informs the application environment that the application is to provide media stream data for playback. The application environment requests media stream data (e.g., samples) from the application, receives them as processed by the application, and provides the requested media stream data for playback. | 11-12-2009 |
20140337433 | Media Streams from Containers Processed by Hosted Code - Described is a technology by which code, such as an untrusted web application hosted in a browser, provides content through an interface for playback by an application environment, such as an application environment running in a browser plug-in. Content may be in the form of elementary video, audio and/or script streams. The content is in a container that is unpackaged by the application code, whereby the content may be packaged in any format that the application understands, and/or or come from any source from which the application can download the container. An application environment component such as a platform-level media element receives information from an application that informs the application environment that the application is to provide media stream data for playback. The application environment requests media stream data (e.g., samples) from the application, receives them as processed by the application, and provides the requested media stream data for playback. | 11-13-2014 |
Patent application number | Description | Published |
20100265086 | VERBAL WARNING SYSTEMS AND OTHER AUDIBLE WARNING SYSTEMS FOR USE WITH VARIOUS TYPES OF DEVICES, CONTAINERS, PRODUCTS AND OTHER THINGS - Verbal warning labels and other audible warning systems for use with different devices, containers, products and other things in various environments are disclosed herein. An audible warning system configured in accordance with an embodiment of the invention includes a device having a standardized textual warning associated therewith, and a sound playback system operably coupled to the device. The sound playback device can be configured to audibly output a verbal warning corresponding to the textual warning. The verbal warning can be provided by at least one of a manufacturer, supplier, distributor or retail vendor of the device, and the verbal warning can supplement or replace the standardized textual warning. | 10-21-2010 |
20130058620 | VIDEO WARNING SYSTEMS FOR DEVICES, PRODUCTS, CONTAINERS AND OTHER ITEMS - Systems and methods for providing video warnings are disclosed herein. A system configured in accordance with one embodiment includes a processor operably coupled to a video screen. A data storage medium containing a video warning can be operably coupled to the processor and an electrical circuit can provide a signal to the processor to initiate display of the video warning on the video screen. In some embodiments, the electrical circuit can include a sensor that produces the signal to initiate the display of the video warning. | 03-07-2013 |
20130058621 | VIDEO WARNING SYSTEMS FOR DEVICES, PRODUCTS, CONTAINERS, AND OTHER ITEMS - Systems and methods for providing video warnings are disclosed herein. A system configured in accordance with one embodiment includes a processor operably coupled to a video screen. A data storage medium containing a video warning can be operably coupled to the processor and an electrical circuit can provide a signal to the processor to initiate display of the video warning on the video screen. In some embodiments, the electrical circuit can include a sensor that produces the signal to initiate the display of the video warning. | 03-07-2013 |
20130058622 | VIDEO WARNING SYSTEMS FOR DEVICES, PRODUCTS, CONTAINERS AND OTHER ITEMS - Systems and methods for providing video warnings are disclosed herein. A system configured in accordance with one embodiment includes a processor operably coupled to a video screen. A data storage medium containing a video warning can be operably coupled to the processor and an electrical circuit can provide a signal to the processor to initiate display of the video warning on the video screen. In some embodiments, the electrical circuit can include a sensor that produces the signal to initiate the display of the video warning. | 03-07-2013 |
20130058623 | VIDEO WARNING SYSTEMS FOR DEVICES, PRODUCTS, CONTAINERS AND OTHER ITEMS - Systems and methods for providing video warnings are disclosed herein. A system configured in accordance with one embodiment includes a processor operably coupled to a video screen. A data storage medium containing a video warning can be operably coupled to the processor and an electrical circuit can provide a signal to the processor to initiate display of the video warning on the video screen. In some embodiments, the electrical circuit can include a sensor that produces the signal to initiate the display of the video warning. | 03-07-2013 |
20130073290 | VERBAL WARNING SYSTEMS AND OTHER AUDIBLE WARNING SYSTEMS FOR USE WITH VARIOUS TYPES OF DEVICES, CONTAINERS, PRODUCTS AND OTHER THINGS - Verbal warning labels and other audible warning systems for use with different devices, containers, products and other things in various environments are disclosed herein. An audible warning system configured in accordance with an embodiment of the invention includes a device having a standardized textual warning associated therewith, and a sound playback system operably coupled to the device. The sound playback device can be configured to audibly output a verbal warning corresponding to the textual warning. The verbal warning can be provided by at least one of a manufacturer, supplier, distributor or retail vendor of the device, and the verbal warning can supplement or replace the standardized textual warning. | 03-21-2013 |
20130073291 | VERBAL WARNING SYSTEMS AND OTHER AUDIBLE WARNING SYSTEMS FOR USE WITH VARIOUS TYPES OF DEVICES, CONTAINERS, PRODUCTS AND OTHER THINGS - Verbal warning labels and other audible warning systems for use with different devices, containers, products and other things in various environments are disclosed herein. An audible warning system configured in accordance with an embodiment of the invention includes a device having a standardized textual warning associated therewith, and a sound playback system operably coupled to the device. The sound playback device can be configured to audibly output a verbal warning corresponding to the textual warning. The verbal warning can be provided by at least one of a manufacturer, supplier, distributor or retail vendor of the device, and the verbal warning can supplement or replace the standardized textual warning. | 03-21-2013 |
20130073292 | VERBAL WARNING SYSTEMS AND OTHER AUDIBLE WARNING SYSTEMS FOR USE WITH VARIOUS TYPES OF DEVICES, CONTAINERS, PRODUCTS AND OTHER THINGS - Verbal warning labels and other audible warning systems for use with different devices, containers, products and other things in various environments are disclosed herein. An audible warning system configured in accordance with an embodiment of the invention includes a device having a standardized textual warning associated therewith, and a sound playback system operably coupled to the device. The sound playback device can be configured to audibly output a verbal warning corresponding to the textual warning. The verbal warning can be provided by at least one of a manufacturer, supplier, distributor or retail vendor of the device, and the verbal warning can supplement or replace the standardized textual warning. | 03-21-2013 |
20130246070 | VERBAL WARNING SYSTEMS AND OTHER AUDIBLE WARNING SYSTEMS FOR USE WITH VARIOUS TYPES OF DEVICES, CONTAINERS, PRODUCTS AND OTHER THINGS - Verbal warning labels and other audible warning systems for use with different devices, containers, products and other things in various environments are disclosed herein. An audible warning system configured in accordance with an embodiment of the invention includes a device having a standardized textual warning associated therewith, and a sound playback system operably coupled to the device. The sound playback device can be configured to audibly output a verbal warning corresponding to the textual warning. The verbal warning can be provided by at least one of a manufacturer, supplier, distributor or retail vendor of the device, and the verbal warning can supplement or replace the standardized textual warning. | 09-19-2013 |
Patent application number | Description | Published |
20080208696 | Point of sale system with web-based back-office - This invention provides a system and a method for managing a range of businesses. The business operations range from a single branch to a large chain of stores or branches. This invention relates to the managing of the points of sale (POS) with Web-based back-office systems. POS transaction engine terminals are implemented on personal computer, PC hardware using PC software with a relational database. The transaction engine architecture provides cost-effective application customization. Web-based back-office software is implemented on servers. POS and BO systems are monitored and supported via the web using protocol and open software components. | 08-28-2008 |
20080208698 | Point of sale video server processing system - This invention provides a system and a method for low cost video surveillance and archiving which is synchronized with point of sale (POS) transactions. There is no local storage of video at the POS. There is high speed transmission of the video out of the stores to central servers. All back office applications are browser based. The system provides for inherent video compression due to hardware and software involved with the video capture. Management can watch present or past store activity anywhere anytime via web browsers. Video records are indexed and retrieved from server memory along with corresponding transaction information. | 08-28-2008 |
20090198595 | Hand-held web browser inventory checking system - This invention provides a system and a method for real-time checking and inputting business inventory. The business operations range from a single branch to a large chain of stores or branches. The application utilizes a hand-held web-browser based system which allows store and business operators to view and input inventory to a back-office server in real-time to assist in the management and security of businesses. The programming for the system resides in an out-of-store back office server. The hand-held device is simply a web browser with a bar code scanner. This system and method facilitates easy inventory checking for real-time theft and loss prevention. | 08-06-2009 |
20090199154 | Web-based point of sale builder - This invention provides a system and a method for online, web-based point of sale (POS) building and configuration, which can assist non-expert business operators in building, editing and testing a point of sale system to manage their businesses. The business operations range from a single branch to a large chain of stores or branches. The key advantages of the Web-based POS builder are that it is completely built on the foundation of the Web. The POS builder is accessible anywhere in the world. It can be used by a person of any skill level. The POS builder builds, edits, and tests new POS terminals in real time. | 08-06-2009 |
Patent application number | Description | Published |
20090177784 | END-POINT IDENTIFIERS IN SIP - A system and method for uniquely identifying an SIP device extends the SIP communications protocol with an end point identifier, carried for example in the header of an SIP transmission. The end point identifier is useful for routing, registration, subscription, and authentication. The end point (device) of a given user epid can be uniquely identified by creating a key from an epid and a user's address-of-record (URI). This in turn enables improved connection management and security association management when the connections/IP addresses are transient, such as when HTTPS tunneling is used. | 07-09-2009 |
20120079014 | METHOD AND SYSTEM FOR DELAYED ALLOCATION OF RESOURCES - The present invention allows a server to delay allocating resources to a client's request. When the client requests a feature that requires server resources, the server accepts and acknowledges the client's request, but the client is prohibited from using the requested feature until further notice from the server. For example, during an authorization process, the server allocates only the minimum resources required to maintain the session and to authorize the client. Thereafter, the server allocates the resources necessary to support the client's request only when the resources become available. Until then, the server maintains the communications session without supporting the request. Thus, the server shepherds its resources rather than committing them at the whim of a client. Also, a client need not repeat its request if the server cannot immediately satisfy it; instead, the server accepts the request and then later begins to support it when adequate resources become available. | 03-29-2012 |
20120084447 | End-Point Identifiers in SIP - A system and method for uniquely identifying an SIP device extends the SIP communications protocol with an end point identifier, carried for example in the header of an SIP transmission. The end point identifier is useful for routing, registration, subscription, and authentication. The end point (device) of a given user epid can be uniquely identified by creating a key from an epid and a user's address-of-record (URI). This in turn enables improved connection management and security association management when the connections/IP addresses are transient, such as when HTTPS tunneling is used. | 04-05-2012 |
20140040484 | END-POINT IDENTIFIERS IN SIP - A system and method for uniquely identifying an SIP device extends the SIP communications protocol with an end point identifier, carried for example in the header of an SIP transmission. The end point identifier is useful for routing, registration, subscription, and authentication. The end point (device) of a given user epid can be uniquely identified by creating a key from an epid and a user's address-of-record (URI). This in turn enables improved connection management and security association management when the connections/IP addresses are transient, such as when HTTPS tunneling is used. | 02-06-2014 |