Patent application number | Description | Published |
20100055711 | METHODS FOR THE IDENTIFICATION OF PI3K INTERACTING MOLECULES AND FOR THE PURIFICATION OF PI3K - The present invention relates to a method for the identification of a PI3K interacting compound, comprising the steps of a) providing a protein preparation containing PI3K, b) contacting the protein preparation with phenylthiazole ligand 1 immobilized on a solid support under conditions allowing the formation of a phenylthiazole ligand 1-PI3K complex, c) incubating the phenylthiazole ligand 1-PI3K complex with a given compound, and d) determining whether the compound is able to separate PI3K from the immobilized phenylthiazole ligand 1. Furthermore, the present invention relates to a method for the identification of a PI3K interacting compound, comprising the steps of a) providing a protein preparation containing PI3K, b) contacting the protein preparation with phenylthiazole ligand 1 immobilized on a solid support and with a given compound under conditions allowing the formation of a phenylthiazole ligand 1-PI3K complex, and c) detecting the phenylthiazole ligand 1-PI3K complex formed in step b). Furthermore, the present invention relates to a method for the identification of a PI3K interacting compound, comprising the steps of a) providing two aliquots of a protein preparation containing PI3K, b) contacting one aliquot with the phenylthiazole ligand 1 immobilized on a solid support under conditions allowing the formation of a phenylthiazole ligand 1-PI3K complex, c) contacting the other aliquot with the phenylthiazole ligand 1 immobilized on a solid support and with a given compound under conditions allowing the formation of a phenylthiazole ligand 1-PI3K complex, and d) determining the amount of the phenylthiazole ligand 1-PI3K complex formed in steps b) and c). Furthermore, the present invention relates to a method for the identification of a PI3K interacting compound, comprising the steps of a) providing two aliquots comprising each at least one cell containing PI3K, b) incubating one aliquot with a given compound, c) harvesting the cells of each aliquot, d) lysing the cells in order to obtain protein preparations, e) contacting the protein preparations with the phenylthiazole ligand 1 immobilized on a solid support under conditions allowing the formation of a phenylthiazole ligand 1-PI3K complex, and f) determining the amount of the phenylthiazole ligand 1-PI3K complex formed in each aliquot in step e). | 03-04-2010 |
20110111972 | SELECTIVITY PROFILING OF PI3K INTERACTING MOLECULES AGAINST MULTIPLE TARGETS - The present invention relates to methods wherein a PI3K interacting compound is identified by incubating a PI3K containing protein preparation with phenyl thiazole ligand 1. | 05-12-2011 |
Patent application number | Description | Published |
20130204578 | Method for Obtaining Information about a Radiation Source or a Material Interacting with a Radiation Source and a Measurement Setup for Performing the Method - A method for obtaining information about an unknown neutron source or an unknown material interacting with a known neutron source comprises the steps of: (a) providing a radiation detector capable of delivering a neutron energy information allowing the production of response histogram(s) as a function of neutron energy, (b) measuring with said radiation detector neutrons being emitted from said unknown neutron source or from said unknown material, (c) deriving from said measured neutrons a neutron energy spectrum, especially in form of a histogram, (d) normalizing said energy spectrum or histogram relative to a parameter or set of parameters derived from the measurement of a different variable, (e) comparing said normalized energy spectrum or histogram with known energy spectra or histograms, and (f) drawing conclusions on the basis of said comparison about the nature of the unknown neutron source or unknown material. | 08-08-2013 |
20140264058 | Method for Obtaining Information Signatures from Nuclear Material or About the Presence, the Nature and/or the Shielding of a Nuclear Material and Measurement Setup for Performing Such Method - The invention relates to a method for obtaining information or signatures about the presence or the nature of a nuclear radiation source, especially in a homeland security application, said nuclear radiation source emitting in a time or angle correlated manner at least a first radiation and a second radiation. The method includes the steps of detecting said first radiation with at least one first radiation detector and detecting said second radiation with at least one second radiation detector. The detection of said second radiation is triggered by said detection of said first radiation in a manner that is adapted to the radiation's correlation structure, thereby increasing the signal-to-background ratio for the detection of said second radiation. | 09-18-2014 |
20140361186 | Method for Detecting and Identifying Nuclear Material in a Container and Radiation Monitoring Arrangement for Conducting the Method - The invention relates to an improved method for detecting and possibly identifying and/or characterizing nuclear and/or radiological material in a container, vehicle, or on a person, comprising the steps of: a. providing at least one detector, which is capable of detecting radiation events being interrelated to nuclear or radiological material; b. bringing the at least one detector in the vicinity of the container, vehicle or person to be monitored; c. detecting radiation events being interrelated to the container, vehicle or person to be monitored; d. assigning each detected radiation event an individual time stamp in order to generate a time pattern of the detected radiation events; and e. analyzing the time pattern with respect to time correlation structures in order to identify a presence and/or characteristics of the nuclear or radiological material. | 12-11-2014 |
20140374606 | Detector Arrangement for the Detection of Ionizing Radiation and Method for Operating Such a Detector Arrangement - A detector arrangement ( | 12-25-2014 |
Patent application number | Description | Published |
20100169997 | PROMOTION OF SOMATIC EMBRYOGENESIS IN PLANTS BY WUSCHEL GENE EXPRESSION - The present invention relates to methods for promoting somatic embryogenesis from a tissue or organ of a plant, by overexpressing a Wuschel gene in said tissue or organ. In one embodiment, such overexpression can be used as a silent selectable marker for transgenic plants. In another embodiment, such expression can be used to confer apomixis to a plant. In another embodiment, such overexpression can be used to create haploid plants, which can be used to produce dihaploid plants. | 07-01-2010 |
20110078823 | PROMOTION OF SOMATIC EMBRYOGENESIS IN PLANTS BY WUSCHEL GENE EXPRESSION - The present invention relates to methods for promoting somatic embryogenesis from a tissue or organ of a plant, by overexpressing a Wuschel gene in said tissue or organ. In one embodiment, such overexpression can be used as a silent selectable marker for transgenic plants. In another embodiment, such expression can be used to confer apomixis to a plant. In another embodiment, such overexpression can be used to create haploid plants, which can be used to produce dihaploid plants. | 03-31-2011 |
20110252506 | PROMOTION OF SOMATIC EMBRYOGENESIS IN PLANTS BY WUSCHEL GENE EXPRESSION - The present invention relates to methods for promoting somatic embryogenesis from a tissue or organ of a plant, by overexpressing a Wuschel gene in said tissue or organ. In one embodiment, such overexpression can be used as a silent selectable marker for transgenic plants. In another embodiment, such expression can be used to confer apomixis to a plant. In another embodiment, such overexpression can be used to create haploid plants, which can be used to produce dihaploid plants. | 10-13-2011 |
20120102594 | PROMOTION OF SOMATIC EMBRYOGENESIS IN PLANTS BY WUSCHEL GENE EXPRESSION - The present invention relates to methods for promoting somatic embryogenesis from a tissue or organ of a plant, by overexpressing a Wuschel gene in said tissue or organ. In one embodiment, such overexpression can be used as a silent selectable marker for transgenic plants. In another embodiment, such expression can be used to confer apomixis to a plant. In another embodiment, such overexpression can be used to create haploid plants, which can be used to produce dihaploid plants. | 04-26-2012 |
20130205442 | PROMOTION OF SOMATIC EMBRYOGENESIS IN PLANTS BY WUSCHEL GENE EXPRESSION - The present invention relates to methods for promoting somatic embryogenesis from a tissue or organ of a plant, by overexpressing a Wuschel gene in said tissue or organ. In one embodiment, such overexpression can be used as a silent selectable marker for transgenic plants. In another embodiment, such expression can be used to confer apomixis to a plant. In another embodiment, such overexpression can be used to create haploid plants, which can be used to produce dihaploid plants. | 08-08-2013 |
Patent application number | Description | Published |
20110212904 | GALACTOSYLATED PRO-DRUGS OF NON-STEROIDAL ANTI-INFLAMMATORIES WITH IMPROVED PHARMACOKINETIC CHARACTERISTICS AND REDUCED TOXICITY OF THE STARTING DRUG - Pro-drugs of all non-steroidal anti-inflammatories with free acid function derivatized with an ester group, which have the general structural formula given below (I) where A is: aspirin, diflunisal, benorylate, ibufenac, diclofenac, indomethacin, sulindac, ketorolac, ibuprofen, naproxen, ketoprofen, fenoprofen, flurbiprofen, mefenamic acid, meclof enamic acid, flufenamic acid, niflumic acid, and where in the ester group R can be a sugar (amongst which aldose, or ketose pentose, or esose selected from a group of D- and L-enantioiuers of ribose, glucose, galactose, mannose, arabinose, xilose, allose, altrose, gulose, idose and talose and substituted derivatives thereof, such as glucosamine, galactosamine, N-acetyl glucosamine, N-acetyl galactosamine, N-acetyl ribosamine), a disaccharide, a trisaccharide or an oligosaccharide. | 09-01-2011 |
Patent application number | Description | Published |
20090298283 | CONDUCTIVE COMPOSITIONS AND PROCESSES FOR USE IN THE MANUFACTURE OF SEMICONDUCTOR DEVICES - ORGANIC MEDIUM COMPONENTS - Embodiments of the invention relate to a silicon semiconductor device, and a conductive paste for use in the front side of a solar cell device. | 12-03-2009 |
20100243048 | METAL PASTES AND USE THEREOF IN THE PRODUCTION OF SILICON SOLAR CELLS - Metal pastes comprising (a) at least one electrically conductive metal powder selected from the group consisting of silver, copper and nickel, (b) at least one lead-free glass frit with a softening point temperature in the range of 550 to 611° C. and containing 11 to 33 wt.-% of SiO | 09-30-2010 |
20100269893 | METAL PASTES AND USE THEREOF IN THE PRODUCTION OF POSITIVE ELECTRODES ON P-TYPE SILICON SURFACES - Metal pastes comprising (a) at least one electrically conductive metal powder selected from the group consisting of silver, copper, and nickel, (b) at least one p-type silicon alloy powder, and (c) an organic vehicle, wherein the p-type silicon alloy is selected from the group consisting of alloys comprising silicon and boron, alloys comprising silicon and aluminum and alloys comprising silicon, boron and aluminum. | 10-28-2010 |
20100294359 | PROCESS OF FORMING A GRID ELECTRODE ON THE FRONT-SIDE OF A SILICON WAFER - A process of forming a front-grid electrode on a silicon wafer having an ARC layer, comprising the steps:
| 11-25-2010 |
20100294360 | PROCESS OF FORMING A GRID ELECTRODE ON THE FRONT-SIDE OF A SILICON WAFER - A process of forming a front-grid electrode on a silicon wafer having an ARC layer, comprising the steps:
| 11-25-2010 |
20100294361 | PROCESS OF FORMING A GRID ELECTRODE ON THE FRONT-SIDE OF A SILICON WAFER - A process of forming a front-grid electrode on a silicon wafer having an ARC layer, comprising the steps: | 11-25-2010 |
20100317143 | PROCESS OF FORMING A SILICON SOLAR CELL - A process for the production of a silicon solar cell comprising application and firing of an aluminum paste which comprises magnesium oxide and/or magnesium compounds capable of forming magnesium oxide on firing on the back-side of a silicon wafer provided with a silicon nitride antireflective coating on its front-side and being contaminated with silicon nitride on its back-side, and firing the aluminum paste after its application. | 12-16-2010 |
20110120551 | PROCESS FOR THE FORMATION OF A SILVER BACK ELECTRODE OF A PASSIVATED EMITTER AND REAR CONTACT SILICON SOLAR CELL - A process for the formation of an electrically conductive silver back electrode of a PERC silicon solar cell comprising the steps:
| 05-26-2011 |
20110139238 | PROCESS FOR THE PRODUCTION OF A MWT SILICON SOLAR CELL - A process for the production of a MWT silicon solar cell comprising the steps:
| 06-16-2011 |
20110146776 | GLASS COMPOSITIONS USED IN CONDUCTORS FOR PHOTOVOLTAIC CELLS - The invention relates to glass compositions useful in conductive pastes for silicon semiconductor devices and photovoltaic cells. | 06-23-2011 |
20110146781 | PROCESS OF FORMING A GRID CATHODE ON THE FRONT-SIDE OF A SILICON WAFER - A process for the production of a grid cathode on the front-side of a silicon wafer by applying and firing a metal paste on the silicon wafer in a front-side grid electrode pattern to form a seed grid cathode and subsequently subjecting the silicon wafer to a LIP process, wherein the metal paste comprises an organic vehicle and an inorganic content comprising (a) 90 to 98 wt.-% of at least one electrically conductive metal powder selected from the group consisting of nickel, copper and silver, and (b) 0.25 to 8 wt.-% of at least one glass frit selected from the group consisting of glass frits containing 47.5 to 64.3 wt.-% of PbO, 23.8 to 32.2 wt.-% of SiO | 06-23-2011 |
20110192456 | PROCESS FOR THE PRODUCTION OF A MWT SILICON SOLAR CELL - A process for the production of a MWT silicon solar cell comprising the steps: | 08-11-2011 |
20110240124 | METAL PASTES AND USE THEREOF IN THE PRODUCTION OF SILICON SOLAR CELLS - Metal pastes comprising (a) at least one electrically conductive metal powder selected from the group consisting of silver, copper and nickel, (b) at least one lead-containing glass frit with a softening point temperature in the range of 571 to 636° C. and containing 53 to 57 wt.-% of PbO, 25 to 29 wt.-% of SiO | 10-06-2011 |
20120199192 | CONDUCTIVE COMPOSITIONS AND PROCESSES FOR USE IN THE MANUFACTURE OF SEMICONDUCTOR DEVICES - ORGANIC MEDIUM COMPONENTS - Embodiments of the invention relate to a silicon semiconductor device, and a conductive paste for use in the front side of a solar cell device. | 08-09-2012 |
20130061918 | PROCESS FOR THE FORMATION OF A SILVER BACK ELECTRODE OF A PASSIVATED EMITTER AND REAR CONTACT SILICON SOLAR CELL - A process for the formation of an electrically conductive silver back electrode of a PERC silicon solar cell comprising the steps:
| 03-14-2013 |
20130074916 | PROCESS FOR THE PRODUCTION OF A MWT SILICON SOLAR CELL - A process for the production of a MWT silicon solar cell, wherein a conductive metal paste with no or only poor fire-through capability is applied, dried and fired to form a continuous metallization comprising a top set of conductive metal collector lines and a metallization of the inside of the holes of a p-type MWT silicon solar cell wafer, wherein the top set of conductive metal collector lines superimposes a bottom set of conductive metal collector lines on the front-side of the p-type MWT silicon solar cell wafer, said bottom set of conductive metal collector lines having no contact with the inside of the holes. | 03-28-2013 |
20130074917 | PROCESS FOR THE PRODUCTION OF A MWT SILICON SOLAR CELL - A process for the production of a MWT silicon solar cell, wherein a conductive metal paste with no or only poor fire-through capability is applied, dried and fired to form a continuous metallization comprising a top set of conductive metal collector lines and a metallization of the inside of the holes of an n-type MWT silicon solar cell wafer, wherein the top set of conductive metal collector lines superimposes a bottom set of conductive metal collector lines on the front-side of the n-type MWT silicon solar cell wafer, said bottom set of conductive metal collector lines having no contact with the inside of the holes. | 03-28-2013 |
20130192670 | ALUMINUM PASTE AND USE THEREOF IN THE PRODUCTION OF PASSIVATED EMITTER AND REAR CONTACT SILICON SOLAR CELLS - An aluminum paste having no or only poor fire-through capability and comprising particulate aluminum, an organic vehicle and at least one glass frit selected from the group consisting of lead-free glass frits containing 0.5 to 15 wt. % SiO | 08-01-2013 |
20130192671 | CONDUCTIVE METAL PASTE AND USE THEREOF - A conductive metal paste having no or only poor fire-through capability and including (a) particulate silver, (b) at least one lead-free glass frit including 0.5 to 15 wt. % SiO | 08-01-2013 |
20130224905 | SILVER PASTE AND USE THEREOF IN THE PRODUCTION OF SOLAR CELLS - A silver paste comprising particulate silver, at least one glass frit, and an organic vehicle, wherein the particulate silver includes 10 to 100 wt-% of spherically-shaped silver particles, based on the total weight of the particulate silver, wherein the spherically-shaped silver particles have an average particle size in the range of 1 to 3 μm, a crystallite size in the range of 40 to 60 nm and a smooth particle surface. | 08-29-2013 |
20130276881 | PROCESS OF FORMING A GRID ELECTRODE ON THE FRONT-SIDE OF A SILICON WAFER - A process of forming a front-grid electrode on a silicon wafer having an ARC layer, comprising the steps:
| 10-24-2013 |
20130340821 | CONDUCTIVE COMPOSITIONS AND PROCESSES FOR USE IN THE MANUFACTURE OF SEMICONDUCTOR DEVICES - ORGANIC MEDIUM COMPONENTS - Embodiments of the invention relate to a silicon semiconductor device, and a conductive paste for use in the front side of a solar cell device. | 12-26-2013 |
Patent application number | Description | Published |
20080292664 | Hydrogels and Hyaluronic Acid and Alpha, Beta-Polyaspartyl-Hydrazide and Their Biomedical and Pharmaceutical Uses - Compositions and products based on the chemical crosslinking of hyaluronic acid with a polyfunctional polymer having a protein-like structure, bearing hydrazido pendent groups along the polymeric chain. The polymer is preferably, alpha-beta-polyaspartylhydrazide, a biocompatible macromolecule. The materials obtained after crosslinking, specifically hydrogels, undergo a reduced chemical and enzymatic degradation, unlike the starting hyaluronic acid, and they can be used to prepare systems for applications in the biomedical and pharmaceutical field. | 11-27-2008 |
20110236486 | METHOD TO PRODUCE HYALURONIC ACID FUNCTIONALIZED DERIVATIVES AND FORMATION OF HYDROGELS THEREOF - A system and method are provided for controlling an internal combustion engine driving a generator/welder or a stand-alone generator. Controlling the engine may include altering the engine speed based upon a detected demand on the generator and/or operating parameters of a welder. For example, the engine speed may be increased based on a detected draw on the generator and/or the operating parameters of the welder. In addition, the engine speed may be automatically decreased to a non-standard idle speed or the engine may be automatically turned off if no demand is detected for a period of time. Additionally, the engine speed may be increased if only frequency-insensitive demands are detected on the generator. Combinations of these and further methods may be executed. Various devices are provided for implementing the above methods. | 09-29-2011 |
20110280921 | ANTIBACTERIAL HYDROGEL AND USE THEREOF IN ORTHOPEDICS - The present invention relates to hydrogels endowed with antibacterial properties, to be used for injection in damaged bones or in the production of antibacterial coatings of prostheses for implant in the human or animal body, obtained by loading with antibacterial agents hydrogels formed by derivatives of hyaluronic acid; the invention also relates to a kit of parts for producing the antibacterial hydrogels. | 11-17-2011 |
20130129800 | HYALURONIC ACID BASED HYDROGEL AND USE THEREOF IN SURGERY - The present invention relates to hydrogels based on hyaluronic acid based derivatives, that are more resistant than hyaluronic acid alone towards chemical and enzymatic degradation and are endowed with a mix of chemical and mechanical properties such that they are of optimal use in several surgeries, for instance for injection in bone fractures or cavities and for the production of coatings of prostheses in orthopedic surgery, as fillers in cosmetic and maxillo-facial surgery, as anti-adhesion barrier in the prevention of postoperative adhesions in abdominal and abdominal/pelvic surgery, and in general surgery. These hydrogels can be loaded with several different kinds of compounds having pharmacological and biological activity, that are then released from the hydrogel in the site of intervention. | 05-23-2013 |
20150183891 | METHOD TO PRODUCE HYALURONIC ACID FUNCTIONALIZED DERIVATIVES AND FORMATION OF HYDROGELS - In this invention a two steps procedure is described useful to insert functional groups to the hyaluronic acid (HA), through the formation, in organic solvent, of a particular active group on hydroxyl groups of HA and subsequent substitution, on the inserted active group, with a pendant portion containing at least in its terminal portion a nucleophilic functional group, NH | 07-02-2015 |
Patent application number | Description | Published |
20090322212 | SYNTHESIS OF NEW ORGANIC MATERIAL FOR POLYMERIC LIGHT EMITTING DIODE - New, highly photoluminescent compounds are described having structural formula (I) | 12-31-2009 |
20100127250 | METHOD FOR REALIZING A THIN FILM ORGANIC ELECTRONIC DEVICE AND CORRESPONDING DEVICE - A method realizes a thin film organic electronic device integrated on a substrate and includes an organic material layer and an organic thin film transistor or OTFT transistor. The method comprises: depositing the organic material layer on the substrate, the organic material layer being a conductive organic polymer; patterning by a soft-lithographic procedure the organic material layer to create a reduced portion in order to make a channel area of the OTFT transistor; masking the organic material layer by covering with a cover mask a source area and a drain area of the OTFT transistor; irradiating by ultraviolet radiation to deactivate exposed portions of the organic material layer defining the source area, the drain area and the channel area; depositing on the organic material layer a semiconductor layer; and creating on the semiconductor layer a gate area of the OTFT transistor. | 05-27-2010 |
20140199807 | THIN FILM TRANSISTORS FORMED BY ORGANIC SEMICONDUCTORS USING A HYBRID PATTERNING REGIME - The present disclosure describes a process strategy for forming bottom gate/bottom contact organic TFTs in CMOS technology by using a hybrid deposition/patterning regime. To this end, gate electrodes, gate dielectric materials and drain and source electrodes are formed on the basis of lithography processes, while the organic semiconductor materials are provided as the last layers by using a spatially selective printing process. | 07-17-2014 |
20140251805 | SENSOR FOR DETECTING HYDROGEN IONS IN AN AQUEOUS SOLUTION - The present disclosure relates to a sensor for detecting hydrogen ions in an aqueous solution comprising a support, a reference electrode, a working electrode and a counter electrode supported by said support, the reference electrode being made of a material comprising silver and silver chloride, the counter electrode being made of a conductive material. The working electrode comprises a substrate and a layer made of an inherently electrically conductive polymer of the polythiophene or polyaniline (PANI) or polypyrrole class. | 09-11-2014 |
Patent application number | Description | Published |
20080260687 | SPECIFIC BINDING AGENTS FOR KSHV vIL-6 THAT NEUTRALIZE A BIOLOGICAL ACTIVITY - A specific binding agent is provided, wherein the specific binding agent specifically binds Kaposi's sarcoma-associated herpesvirus (KSHV) interleukin-6 (vIL-6), and the specific binding agent neutralizes an activity of vIL-6. In one embodiment, the specific binding agent is an antibody. Methods are provided for using a specific binding agent that binds vIL-6, and neutralizes a biological activity of vIL-6. Methods of treatment for a KSHV-associated disorder are also provided. Methods for diagnosing a KSHV-associated disorder are provided, as are kits that include a specific binding agent of the invention. A method is also provided for testing an agent for effectiveness in treating a KSHV-associated disorder. The method includes incubating the agent with a cell free system comprising a vIL-6 receptor component and vIL-6, and comparing the binding of vIL-6 and the receptor component in the presence of the agent to binding of vIL-6 to the receptor component in the absence of the agent. A decrease in the binding of vIL-6 to the receptor component in the presence of the agent indicates that the agent is effective for treating the KSHV-associated disorder. | 10-23-2008 |
20090149380 | VASOSTATIN AS MARROW PROTECTANT - Specific fragments of vasostatin are disclosed. These fragments are of use in methods of stimulating the proliferation or survival of a hematopoietic cell exposed to a chemotherapeutic agent or irradiation. Methods of stimulating the proliferation or survival of a hematopoietic cell using these fragments are also disclosed. In one embodiment, methods are disclosed for stimulating the growth or survival of a hematopoietic stem cell with a fragment of vasostatin, in the presence of a growth factor. | 06-11-2009 |
20100297124 | INDUCED INTERNALIZATION OF SURFACE RECEPTORS - Disclosed is a hetero-bifunctional ligand for use in inducing internalization of a target receptor. The hetero-bifunctional ligand includes a target receptor-binding agent that specifically binds the target receptor linked to an internalizing receptor-binding agent that specifically binds to an internalizing receptor, where the two binding agents are non-identical. Also disclosed is a method of inducing the internalization of a target receptor on a cell. The method includes contacting a cell with a hetero-bifunctional ligand, where binding of the hetero-bifunctional ligand induces internalization of a target receptor of the cell. Also disclosed a method of treating a disease or condition associated with a target receptor using the disclosed hetero-bifunctional ligand and pharmaceutical compositions including a hetero-bifunctional ligand. | 11-25-2010 |
20130243769 | INDUCED INTERNALIZATION OF SURFACE RECEPTORS - Disclosed is a hetero-bifunctional ligand for use in inducing internalization of a target receptor. The hetero-bifunctional ligand includes a target receptor-binding agent that specifically binds the target receptor linked to an internalizing receptor-binding agent that specifically binds to an internalizing receptor, where the two binding agents are non-identical. Also disclosed is a method of inducing the internalization of a target receptor on a cell. The method includes contacting a cell with a hetero-bifunctional ligand, where binding of the hetero-bifunctional ligand induces internalization of a target receptor of the cell. Also disclosed is a method of treating a disease or condition associated with a target receptor using the disclosed hetero-bifunctional ligand and pharmaceutical compositions including a hetero-bifunctional ligand. | 09-19-2013 |
Patent application number | Description | Published |
20080215124 | Apparatus for Cosmetic Skin Rejuvenation Treatment - The present invention relates to an apparatus for cosmetic skin rejuvenation treatment, comprising a continuous wave light source accommodating a high-intensity discharge lamp ( | 09-04-2008 |
20080255547 | Uv Lamp for Treatment of the Skin - UV lamp for treatment of the skin, which lamp has a radiation capacity substantially entirely in the UV spectrum and in the red-light spectrum, wherein the radiation capacity of the lamp in the red light spectrum between 600 nm and 700 nm is at least 3% of the radiation capacity in the UV spectrum. In a first embodiment the lamp is a UV fluorescent lamp, having a first UV emitting phosphor and a second red light emitting phosphor, wherein the red light emitting phosphor is CeGdMgB | 10-16-2008 |
20090005838 | TANNING APPARATUS - Indoor tanning, especially in commercial establishments which provide tanning beds, has been a very popular endeavour for the last few decades, particularly in view of concerns for exposure to natural sunlight and ultra-violet (UV) light. The invention relates to an improved tanning apparatus, having multiple light sources ( | 01-01-2009 |
20100179622 | SKIN TREATMENT DEVICE, LAMP AND USE - The invention relates to a skin treatment device, a lamp for use in such a skin treatment device, and its use. The skin treatment device according to the invention uses a combination of tanning-effective and/or anti-acne effective amounts of blue light in the spectral range from 400-440 nm in addition to the UV-light known in the art. An important advantage is that a lower UV dose can be used, leading to lower health risks, while the exposure times can be kept within acceptable limits, without compromising the skin treatment result. | 07-15-2010 |
20120101557 | TREATMENT APPARATUS AND USE THEREOF FOR TREATING PSORIASIS - A treatment apparatus ( | 04-26-2012 |
20120150264 | SKIN RADIATION APPARATUS AND METHOD - A skin radiation apparatus comprises: —a photon radiation unit ( | 06-14-2012 |
20120165907 | LIGHT TREATMENT SYSTEM - The invention relates to a light treatment system ( | 06-28-2012 |
20120172949 | SKIN RADIATION APPARATUS - A skin radiation apparatus ( | 07-05-2012 |
20130144364 | FLEXIBLE LIGHT THERAPY DEVICE, A PLASTER AND A BANDAGE - A flexible light therapy device, a bandage and a plaster for providing a therapeutic effect to a treatment target area ( | 06-06-2013 |
20130334973 | Apparatus and Method for Luminance Control - A control unit for controlling luminance in a space, the control unit being configured to estimate a trajectory of a target relative to the space, and control the luminance in the space based on the estimated trajectory and on a function rate corresponding to an adaptability of the target eye to changes in luminance. | 12-19-2013 |
20140292206 | METHODS AND APPARATUS FOR CONTROL OF ILLUMINATION IN AN INTERIOR SPACE - Methods and apparatus related to controlling illumination in a space. The method may include determining a heading of a daylight blocking element and/or a lighting fixture ( | 10-02-2014 |