Patent application number | Description | Published |
20080293152 | NANOMEMBRANES FOR REMOTE SENSING - The present invention provides sensors for use in detecting the presence or absence of analytes, systems incorporating the sensors, and methods for using the sensors. The sensors include thin membranes that undergo a detectable geometry change upon exposure to an analyte. In one exemplary embodiment, the sensors are small, thin-film membranes that include a stained semiconductor bilayer, wherein an interaction between the membrane and an analyte induces a detectable change in a strain-induced curvature of the membrane. | 11-27-2008 |
20080300663 | NANO- AND MICRO-SCALE WIRELESS STIMULATING PROBE - Untethered micro or nanoscale probes may be dispersed within tissue to be individually addressed through external electromagnetic radiation to create local electrical currents used for direct stimulation, alteration of cellular potentials, or the release or modification of contained or attached chemical compounds. | 12-04-2008 |
20090015351 | NANO-ELECTROMECHANICAL CIRCUIT USING CO-PLANAR TRANSMISSION LINE - A co-planar waveguide structure is integrated with an upwardly extending resonant pillar to produce transfer cells that provide controlled transmission of electricity between adjacent structures of the co-planar waveguide in order to produce easily fabricated electronic devices operating at megahertz and gigahertz speeds for filtration, modulation, rectification, and mixing of high-frequency signals. | 01-15-2009 |
20090321633 | NANOPILLAR ARRAYS FOR ELECTRON EMISSION - The present invention provides systems, devices, device components and structures for modulating the intensity and/or energies of electrons, including a beam of incident electrons. In some embodiments, for example, the present invention provides nano-structured semiconductor membrane structures capable of generating secondary electron emission. Nano-structured semiconductor membranes of this aspect of the present invention include membranes having an array of nanopillar structures capable of providing electron emission for amplification, filtering and/or detection of incident radiation, for example secondary electron emission and/or field emission. Nano-structured semiconductor membranes of the present invention are useful as converters wherein interaction of incident primary electrons and nanopillars of the nanopillar array generates secondary emission. Nano-structured semiconductor membranes of this aspect of the present invention are also useful as directed charge amplifiers wherein secondary emission from a nanopillar array provides gain functionality for increasing the intensity of radiation comprising incident electrons. | 12-31-2009 |
20100127716 | RADIO-FREQUENCY ION CHANNEL PROBE - A patch-clamp system employs a high-frequency characterization of cell wall membranes. Changes in the frequency response of a tank circuit incorporating the cell wall membrane impedance provides highly sensitive and highly time-resolved measurements of ion channel activity. | 05-27-2010 |
20100129603 | RETRO-PERCUSSIVE TECHNIQUE FOR CREATING NANOSCALE HOLES - A method of forming extremely small pores in glass or a similar substrate, useful, for example, in patch clamp applications, that employs a backer plate to contain energy of a laser-induced ablation through the front surface of the substrate so as to create a rear surface shock wave providing a fire polishing of the exit aperture of the pore such as produces improved sealing with cell membranes. | 05-27-2010 |
20100320372 | MOLECULE MASS DETECTION VIA FIELD EMISSION OF ELECTRONS FROM MEMBRANES - An active detector and methods for detecting molecules, including large molecules such as proteins and oligonucleotides, at or near room temperature based on the generation of electrons via field emission (FE) and/or secondary electron emission (SEE). The detector comprises a semiconductor membrane having an external surface that is contacted by one or more molecules, and an internal surface having a thin metallic layer or other type of electron emitting layer. The kinetic energy of molecules contacting the semiconductor membrane is transferred through the membrane and induces the emission of electrons from the emitting layer. An electron detector, which optionally includes means for electron amplification, is positioned to detect the emitted electrons. | 12-23-2010 |
20110111179 | LASER DRILLING TECHNIQUE FOR CREATING NANOSCALE HOLES - A method of forming extremely small pores in a substrate that is used, for example, in patch clamp applications is provided that employs an energy absorbing material beyond a back side of the substrate to allow a laser to be focused adjacent the exit side of the substrate so as to generate a pore through the substrate and can also form a crater in the back side of the substrate and in which the pore may propagate from the crater in a drilling direction that can oppose a laser transmission direction. | 05-12-2011 |
20110220959 | High-Frequency Bridge Suspended Diode - A high-frequency metal-insulator-metal (MIM) type diode is constructed as a bridge suspended above a substrate to significantly reduce parasitic capacitances affecting the operation frequency of the diode thereby permitting improved high-frequency rectification, demodulation, or the like. | 09-15-2011 |
20110248903 | COUPLED ELECTRON SHUTTLE PROVIDING ELECTRICAL RECTIFICATION - A nanoscale electron shuttle with two elastically mounted conductors positioned within a gap between conductors produces asymmetrical electron conduction between the conductors when the conductors receive an AC signal to provide for rectification, detection and/or power harvesting. | 10-13-2011 |
20120064628 | TUBULAR SCAFFOLD FOR NEURAL GROWTH - A scaffold for neurons consists of tubes sized to promote neural growth through the tubes. The tubes may be fixed to a substrate providing electrical or optical paths out from the interior of the tubes from sensors or stimulating probes at one or more locations along the length of the coaxial axons. Steering electrodes at spaces between tubes may be used to selectively promote the growth of interconnections of different axons in a one, two, or three-dimensional fashion. | 03-15-2012 |
20120074313 | Microwave Cavity Detector for Mass Spectrometry - A detector for time of flight mass spectroscopy uses a microwave resonant cavity excited into resonance by the passage of charged particles as an ion detector. With proper configuration of the frequency of resonance of the cavity, its modes and its quality factor, nanosecond time resolution, should be possible. | 03-29-2012 |
20120119837 | Nanoscale Electromagnetic Radiation Device Using Serpentine Conductor - A nanoscale serpentine ribbon is used to produce electromagnetic radiation by accelerating charge carriers as constrained along a serpentine path defined by the ribbon so that curve portions of the ribbon promote acceleration-induced emission of electromagnetic radiation by the charge carriers. | 05-17-2012 |
20120141729 | Retro-Percussive Technique for Creating Nanoscale Holes - A method of forming extremely small pores in glass or a similar substrate, useful, for example, in patch clamp applications, that employs a backer plate to contain energy of a laser-induced ablation through the front surface of the substrate so as to create a rear surface shock wave providing a fire polishing of the exit aperture of the pore such as produces improved sealing with cell membranes. | 06-07-2012 |
20130098762 | Patch-Clamp Providing On-Chip Thermal Gradient - A patch clamp system providing precise and rapid temperature control of constrained cell membranes employs the thermal element attached to the substrate of the patch clamp. In one embodiment, the thermal element is a Peltier device fabricated on a silicon membrane wafer bonded to the substrate of the patch clamp. | 04-25-2013 |
20130126726 | Molecule Mass Detection via Field Emission of Electrons from Membranes - An active detector and methods for detecting molecules, including large molecules such as proteins and oligonucleotides, at or near room temperature based on the generation of electrons via field emission (FE) and/or secondary electron emission (SEE). The detector comprises a semiconductor membrane having an external surface that is contacted by one or more molecules, and an internal surface having a thin metallic layer or other type of electron emitting layer. The kinetic energy of molecules contacting the semiconductor membrane is transferred through the membrane and induces the emission of electrons from the emitting layer. An electron detector, which optionally includes means for electron amplification, is positioned to detect the emitted electrons. | 05-23-2013 |
20130182481 | Coupled Electron Shuttle Providing Electrical Rectification - A nanoscale electron shuttle with two elastically mounted conductors positioned within a gap between conductors produces asymmetrical electron conduction between the conductors when the conductors receive an AC signal to provide for rectification, detection and/or power harvesting. | 07-18-2013 |
20130249530 | PIEZOELECTRIC SUBSTRATE FOR THE STUDY OF BIOMOLECULES - A method of forming extremely small pores in a substrate may be used to produce, for example, an apparatus for the study of biological molecules, by providing a small pore in a piezoelectric substrate having electrodes, the latter that may be energized to change the pore dimensions. | 09-26-2013 |
20140029634 | SEMICONDUCTOR MICROTUBE LASERS - Disclosed are semiconductor microtube lasers including a semiconductor multilayer heterostructure. The multilayer heterostructure includes a substantially cylindrical optically active structure capable of light emission when under the influence of an applied electromagnetic field and a substantially cylindrical distributed feedback grating structure configured to provide optical feedback for a selected wavelength of light from the optically active region and to produce lasing action from the microtube when under the influence of an applied electromagnetic field. | 01-30-2014 |
20140253153 | Radio-Frequency Ion Channel Antenna - An antenna is used for radio frequency measurements of cell wall impedance changes due to ion channels. The antenna provides enhanced direct readout of lipid bilayers and cells containing pores and ion channels. The antenna is placed around a nanopore, which may be fabricated from glass, quartz or other material, and is shaped to provide an enhanced sensitivity to electrical activity in the vicinity of the nanopore. As such, the antenna may be of a class of bi-cone- or other stub-antennas providing high gain and broad bandwidth, for example a planar variant of a “bow-tie” antenna. Accordingly, improved sensitivity of at least an order of magnitude may be achieved over past systems. | 09-11-2014 |
20140254856 | Eardrum Supported Nanomembrane Transducer - A flexible membrane of piezoelectric material sized to be supported by and to conform to the eardrum. Electrodes on the membrane allow the membrane to function as an audio transducer stimulating the eardrum with an audio signal or detecting audio signals at the eardrum. Applications may include detecting a variety of pathophysiological and biomechanical features of the tissues of the tympanic membrane and regional integrated anatomy, detecting audio, physical and biological signals, and/or delivery a variety of therapeutic modalities. | 09-11-2014 |
20140266147 | System and Apparatus for Nanopore Sequencing - A piezoelectric substrate having a nanopore opening that separates two reservoirs of conductive fluid may provide for sensitive biological measurements by allowing control of the size of the nanopore according to piezoelectric stimulation of the substrate. Multiple embodiments are provided of monolithic piezoelectric substrates and nanopores for this purpose as well as a control system for controlling the nanopore dimensions electrically using AC or DC waveforms. | 09-18-2014 |