Shukla, US
Abhinav A. Shukla, Manlius, NY US
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20090306351 | Wash Buffer And Method Of Using - A method for purifying a protein using Protein A chromatography comprising a) absorbing the protein to Protein A immobilized on a solid support; b) removing contaminants by washing the immobilized Protein A containing the absorbed protein with a buffer comprising one or more chaotropic agents in combination with one or more hydrophobic modifiers and having a pH of at least 7.0; and c) eluting the protein from the Protein A immobilized on the solid support. | 12-10-2009 |
Amitabh Shukla, Loveland, CO US
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20090299650 | SYSTEMS AND METHODS FOR FILTERING TARGET PROBE SETS - Systems and methods for using the same to filter target probes sets are provided. In certain embodiments, the system and methods are implemented on a web-based platform. Also provided are computer program products for executing the subject methods. | 12-03-2009 |
Anand Shukla, Westminster, CO US
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20110257991 | Pharmacy Product Inventory Control or Redistribution - A method to reduce or eliminate the generation of expired products and manage pharmacy inventories. The method includes maintaining an online pharmacy inventory database among a plurality of participating network pharmacies, identifying over-stock products, non-moving products, slow moving products, and un-wanted products from the plurality of participating network pharmacies, and generating a redistribution list of one or more products. | 10-20-2011 |
Anita Shukla, Cambridge, MA US
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20090258045 | STRUCTURES INCLUDING ANTIMICROBIAL PEPTIDES - A structure includes a substrate and a first plurality of bilayers on the substrate. The first plurality of bilayers includes a first layer including an antimicrobial peptide having a charge, and a second layer including a polyelectrolyte having a charge opposite the charge of the first layer. At least a portion of the structure is capable of degrading by sequential removal of the first layer and the second layer, and releasing the antimicrobial peptide from the structure. | 10-15-2009 |
20130273137 | DRUG DELIVERY COATING AND DEVICES - In various embodiments, the present invention provides certain systems comprising a multi-layer decomposable film coating composition on a substrate, where the coating composition includes one or more releasable agents in at least one of its layers, and decomposes layer-by-layer to release such agent(s) over time. In some embodiments, an intra-ocular lens (IOL) system comprising an IOL coated with a multi-layer decomposable film coating composition is disclosed. | 10-17-2013 |
Anita Shukla, Houston, TX US
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20120277719 | COATING COMPOSITIONS, METHODS AND COATED DEVICES - The present disclosure provides, am ng other things, a coated device comprising: a porous substrate; a film coating at least part of the substrate, which film comprises a multilayer unit comprising a first layer and a second layer adjacent to the first layer, wherein the first layer comprises a first polymeric material and at least first interacting moiety, wherein the second layer comprises a second polymeric material and at least second interacting moiety, and wherein the interacting moieties on adjacent layers interact with one another so that the adjacent layers are associated with each other into the film; and an agent for delivery associated with the coated device, such that decomposition of one or more layers of the film results in release of the agent. | 11-01-2012 |
20120277852 | COATING COMPOSITIONS, METHODS AND COATED DEVICES - In various embodiments, a coated device comprises: a substrate; a film coating at least part of the substrate, which film comprises a multilayer unit comprising a first layer and a second layer associated with one another via a hydrogen bond, wherein the first layer comprises a first natural polymeric material and a hydrogen bond donor and wherein the second layer comprises a second natural polymeric material and a hydrogen bond acceptor; and an agent for delivery associated with the coated device. In various embodiments, a coated device comprises: a substrate; a film coating at least part of the substrate, which film comprises a multilayer unit comprising a tetralayer with alternating layers of opposite charge; and an agent for delivery associated with the coated device. | 11-01-2012 |
Ashish V. Shukla, Allentown, PA US
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20120326768 | Hybrid Impedance Compensation in a Buffer Circuit - A compensation circuit for controlling a variation in output impedance of at least one buffer circuit includes a monitor circuit and a control circuit coupled with the monitor circuit. The monitor circuit includes a pull-up portion including at least one PMOS transistor and a pull-down portion comprising at least one NMOS transistor. The monitor circuit is configured to track an operation of an output stage of the buffer circuit and is operative to generate at least a first control signal indicative of a status of at least one characteristic of corresponding pull-up and pull-down portions in the output stage of the buffer circuit over variations in PVT conditions to which the buffer circuit may be subjected. The control circuit is operative to generate a set of digital control bits as a function of the first control signal. The set of digital control bits is operative to compensate the pull-up and pull-down portions in the output stage of the buffer circuit over prescribed variations in PVT conditions. | 12-27-2012 |
Ashutosh M. Shukla, Little Rock, AR US
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20130210861 | METHODS AND COMPOSITIONS FOR MANAGING CARDIOVASCULAR DISEASE ASSOCIATED WITH CHRONIC KIDNEY DISEASE - Methods of treating cardiovascular disease in patients predisposed to or afflicted with kidney disease, particularly chronic kidney disease, are described. In such methods, therapeutically effective amounts of chloroquine-based compounds, for example, hydroxychloroquine, are administered to prevent or otherwise ameliorate arthrosclerosis and other cardiovascular diseases. | 08-15-2013 |
Atul Shukla, Cordova, TN US
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20120107393 | Pellets for Delivery of Biologically Active Substances - Pellets are made by combining a direct compression binder and a waxy spheronizing agent. The pellets may further contain additional pharmaceutical ingredients and/or a drug. The pellets may be compressed to form tablets or loaded into a capsule shell for oral administration, and the pellets may or may not have an additional coating. | 05-03-2012 |
Atul J. Shukla, Cordova, TN US
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20080300322 | Delivery vehicles containing rosin resins - Compositions containing a vehicle containing a rosin resin or derivative and a non-volatilized solvent or plasticizer. The compositions may be used to deliver a biologically active substance such as an active pharmaceutical ingredient. The concentration of rosin resin or derivative in the vehicle is sufficient to alter the release rate from the composition of a biologically active substance that is dissolved, dispersed, emulsified, or suspended in the vehicle. | 12-04-2008 |
20090239891 | Sustained Release Dosage Forms of Analgesic Medications - Parenteral extravascular administration of a composition containing an analgesic medication of low water solubility that is dissolved, suspended, or emulsified in a solvent system results in the deposition of the analgesic medication at the site of administration and provides a controlled release of the analgesic medication from the site and a prolonged analgesia that may persist for several days following administration. | 09-24-2009 |
20100099696 | Tamper resistant oral dosage forms containing an embolizing agent - Oral dosage form containing a therapeutically effective amount of a drug susceptible to abuse and an effective amount of an embolizing agent which causes the production of a solid or semi-solid embolus or blockage after tampering. | 04-22-2010 |
20120207797 | DOSAGE FORMS FOR TAMPER PRONE THERAPEUTIC AGENTS - A dosage form from which a burst release of a drug contained within a tampered dosage form is reduced or retarded by the presence in or on the dosage form of a TPTA (Tamper Prone Therapeutic Agent) trap. If the dosage form has not been tampered with, the TPTA trap does not significantly interfere with the rate of release of the drug from the dosage form. However, if the dosage form has been physically tampered with, the TPTA trap reduces or retards burst release of the drug from the dosage form. | 08-16-2012 |
20130095148 | Dosage Forms for Tamper Prone Therapeutic Agents - A dosage form from which a burst release of a drug contained within a tampered dosage form is reduced or retarded by the presence in or on the dosage form of a TPTA (Tamper Prone Therapeutic Agent) trap. If the dosage form has not been tampered with, the TPTA trap does not significantly interfere with the rate of release of the drug from the dosage form. However, if the dosage form has been physically tampered with, the TPTA trap reduces or retards burst release of the drug from the dosage form. | 04-18-2013 |
20130224265 | Dosage Forms for Tamper Prone Therapeutic Agents - A dosage form from which a burst release of a drug contained within a tampered dosage form is reduced or retarded by the presence in or on the dosage form of a TPTA (Tamper Prone Therapeutic Agent) trap. If the dosage form has not been tampered with, the TPTA trap does not significantly interfere with the rate of release of the drug from the dosage form. However, if the dosage form has been physically tampered with, the TPTA trap reduces or retards burst release of the drug from the dosage form. | 08-29-2013 |
Brian A. Shukla, St. Paul, MN US
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20090011388 | SELF-ETCHING DENTAL COMPOSITIONS AND METHODS - The present invention is directed to dental compositions that can be used as adhesives for bonding a dental material to a dental structure surface and/or as a dental restorative material. The dental composition is preferably applied to a dental structure surface under conditions effective to etch the dental structure surface. | 01-08-2009 |
Brian A. Shukla, Woodbury, MN US
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20080293846 | Dental Compositions with Surface-Treated Filler for Shelf Stability - The invention features dental compositions containing a basic filler that has been surface-treated with a strong acid to increase the shelf life of the composition. | 11-27-2008 |
20080306168 | Dental Compositions with a Water Scavenger - The present invention relates to polymerizable dental compositions that contain a water scavenger, such as a molecular sieve, to increase the shelf life of the composition. | 12-11-2008 |
20090005469 | Dental Compositions and Initiator Systems with Polycyclic Aromatic Component - The invention features a polymerizable composition that comprises a free-radically polymerizable acidic resin, and a photoinitiator system comprising a polycyclic aromatic component. The photoinitiator system may also contain a visible light sensitizer, an iodonium salt, and a tertiary amine. | 01-01-2009 |
20100090157 | ADHESIVE COMPOSITION FOR HARD TISSUE - An adhesive composition including an etchant for a hard tissue surface, at least one multifunctional crosslinkable (meth)acrylate monomer with a functionality greater than 4, and water. The adhesive composition is a water-in-oil emulsion. | 04-15-2010 |
20130164709 | SUBSTITUTED SACCHARIDE COMPOUNDS AND DENTAL COMPOSITIONS - Substituted saccharide compounds, dental compositions comprising substituted saccharide compounds, and methods of using dental compositions are described. In one embodiment, the substituted saccharide amide compound comprises a hydrophobic group and at least one free-radically polymerizable group with the proviso that the hydrophobic group is not bonded to the ethylenically unsaturated carbon atom of the free-radically polymerizable group. The hydrophobic group is typically bonded to a nitrogen atom of a saccharide amine residue or a carbonyl moiety of saccharide amide residue. | 06-27-2013 |
20130224692 | ADHESIVE COMPOSITION SUITABLE FOR DENTAL USES - A dental adhesive composition is described comprising a photocurable ionomer, radiopaque metal oxide nanoparticles, a phosphorous-containing acidic monomer, other polymerizable resin components, and a polar solvent. In a favored embodiment, the adhesive composition comprises a photocurable ionomer in an amount up to 15 wt-%; 5 wt-% to 30 wt-% of radiopaque metal oxide nanoparticles that comprise a basic surface (such as zirconia) wherein the nanoparticles comprise an organosilane surface treatment; a phosphorous-containing acidic monomer in an amount up to 10 wt-%; and 10 wt-% to 50 wt-% of solvent comprising water and at least one alcohol, ketone, or mixture thereof. | 08-29-2013 |
Deepak Shukla, Orland Park, IL US
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20130189784 | ANTI-HEPARAN SULFATE PEPTIDES THAT BLOCK HERPES SIMPLEX VIRUS INFECTION IN VIVO - Provided are anti-heparan sulfate peptides and methods that employ those peptides for the prevention or treatment of viral infections, including herpesviral infections such as α-herpesviral, β-herpesviral, and γ-herpesviral infections, which are exemplified by HSV-1. CMV, and HHV-8 viral infections, respectively. Peptides may comprise at least 10 amino acids of the amino acid sequences X | 07-25-2013 |
20140056947 | VIRUS TRAPS - Specific applications of particles and particle agglomerates with semiconductor surfaces are provided. The particles and particle agglomerates display a high affinity for viral particles, and may be used therapeutically and/or prophylactically to treat or prevent viral infections. The particles and particle agglomerates may also be used to remove viral particles from a surface or fluid, e.g., as an absorbent in a filter, applied to surfaces to render them virostatic, and as tool to handle viral particles, e.g., for research, diagnostic, or decontamination purposes. | 02-27-2014 |
Himanshu Shukla, Scottsdale, AZ US
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20100114152 | Minimally-Invasive Method and Device for Permanently Compressing Tissues within the Body - The present invention is method for permanently compressing tissues in the body. The method employs a compression device made of a spring and a flexible sheet that cooperate to form a compressive envelope around the desired tissue. The spring is preferably Z-shaped or a coil. The sheet is made of a flexible material and the material is preferably elastic. The sheet is preferably a biocompatible elastic material, such as a mesh made of stainless steel or a woven or non-woven elastomer. The method is minimally invasive because it deploys the compression device through the patient's skin directly to the tissue, as opposed to through catheterization or open invasive surgery, such as open-heart surgery. The preferred use is for compressing the left atrial appendage to prevent clots from forming and circulating, thereby preventing strokes. The device is deployed by making an incision in a patient's chest, inserting the compression device through the incision into the pericardium without piercing the heart, and deploying it around the entire appendage. The device remains in place by its own compressive nature: either the spring, the sheet, or both components compress the appendage and cause the device to stay in place due to friction. Preferably the entire compression device is left in place, but the spring or the sheet may be removed, leaving the remaining component to compress the appendage. | 05-06-2010 |
Hridayabhiranjan Shukla, Ballwin, MO US
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20080276334 | Nucleic acid molecules and other molecules associated with plants - Expressed Sequence Tags (ESTS) isolated from soybean are disclosed. The ESTs provide a unique molecular tool for the targeting and isolation of novel genes for plant protection and improvement. The disclosed ESTs have utility in the development of new strategies for understanding critical plant developmental and metabolic pathways. The disclosed ESTs have particular utility in isolating genes and promoters, identifying and mapping the genes involved in developmental and metabolic pathways, and determining gene function. Sequence homology analyses using the ESTs provided in the present invention, will result in more efficient gene screening for desirable agronomic traits. An expanding database of these select pieces of the plant genomics puzzle will quickly expand the knowledge necessary for subsequent functional validation, a key limitation in current plant biotechnology efforts. | 11-06-2008 |
20090087878 | Nucleic acid molecules associated with plants - Polynucleotides useful for improvement of plants are provided. In particular, polynucleotide sequences are provided from plant sources. Polypeptides encoded by the polynucleotide sequences are also provided. The disclosed polynucleotides and polypeptides find use in production of transgenic plants to produce plants having improved properties. | 04-02-2009 |
20090217414 | Nucleic acid molecules and other molecules associated with plants and uses thereof for plant improvement - Polynucleotides useful for improvement of plants are provided. In particular, polynucleotide sequences are provided from plant sources. Polypeptides encoded by the polynucleotide sequences are also provided. The disclosed polynucleotides and polypeptides find use in production of transgenic plants to produce plants having improved properties. | 08-27-2009 |
20100261614 | Bacillus thuringiensis Chromosomal Genome Sequences and Uses Thereof - The present invention relates to nucleic acid sequences from | 10-14-2010 |
20100293663 | Nucleic Acid Molecules and Other Molecules Associated with Plants and Uses Thereof for Plant Improvement - Polynucleotides useful for improvement of plants are provided. In particular, polynucleotide sequences are provided from plant sources. Polypeptides encoded by the polynucleotide sequences are also provided. The disclosed polynucleotides and polypeptides find use in production of transgenic plants to produce plants having improved properties. | 11-18-2010 |
20110214206 | Nucleic acid molecules and other molecules associated with plants - Polynucleotides useful for improvement of plants are provided. In particular, polynucleotide sequences are provided from plant sources. Polypeptides encoded by the polynucleotide sequences are also provided. The disclosed polynucleotides and polypeptides find use in production of transgenic plants to produce plants having improved properties. | 09-01-2011 |
20120216318 | Nucleic acid molecules and other molecules associated with plants - Polynucleotides useful for improvement of plants are provided. In particular, polynucleotide sequences are provided from plant sources. Polypeptides encoded by the polynucleotide sequences are also provided. The disclosed polynucleotides and polypeptides find use in production of transgenic plants to produce plants having improved properties. | 08-23-2012 |
Jagdeesh Shukla, Oswego, IL US
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20140108038 | Universal Charge Routing System for Medical Billing - A medical charge router receives charge information from a variety of sources and converts it to a standard charge format for automated processing and routing to one of multiple billing programs.) | 04-17-2014 |
Krishna Shukla, Cordova, TN US
Patent application number | Description | Published |
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20120107393 | Pellets for Delivery of Biologically Active Substances - Pellets are made by combining a direct compression binder and a waxy spheronizing agent. The pellets may further contain additional pharmaceutical ingredients and/or a drug. The pellets may be compressed to form tablets or loaded into a capsule shell for oral administration, and the pellets may or may not have an additional coating. | 05-03-2012 |
Kunal Shukla, Longmont, CO US
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20080207177 | METHOD AND APPARATUS PROVIDING VOICE MAIL SERVICE FOR HALF DUPLEX WIRELESS COMMUNICATION SYSTEMS - A software and hardware implementation of a Half Duplex Voice Mail Server (HD-VMS), which provides subscription-based voice mail services for users in half duplex wireless networks. The user subscribes to the service and is provided with a voice mail box which records caller voice messages for the user when the user's handset is powered off or out of service, or when the user has enabled a privacy feature. The HD-VMS can be implemented in existing half duplex networks with minimal changes to the network. The implementation is technology independent and may be extended to host multiple half duplex communications technologies within the same network. | 08-28-2008 |
Manu Shukla, Sterling, VA US
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20130080434 | Systems and Methods for Contextual Analysis and Segmentation Using Dynamically-Derived Topics - Systems and methods are disclosed for contextual analysis and segmentation of information objects. According to one implementation, information objects, such as web pages and user profiles, may be analyzed to identify key terms. These key terms may be included in a contextual representation of an information object. By comparing the contextual representations of a plurality of information objects, one or more contextual segments (i.e., categories of information objects) may be created. Each contextual segment may also be associated with its own contextual representation. Once a contextual segment has been created, information objects may be assigned to the contextual segment. These contextual segments may be used to deliver targeted advertising, for example. | 03-28-2013 |
20130080439 | Systems and Methods for Contextual Analysis and Segmentation of Information Objects - Systems and methods are disclosed for contextual analysis and segmentation of information objects. In accordance with one implementation, information objects, such as web pages and user profiles, may be processed to obtain a list of key terms. An index may be created containing each of the information objects and associated key terms. Information objects may then be matched to contextual segments (i.e., categories of information objects) by submitting terms associated with the contextual segments against the index. Further, thresholding may be applied, so that only the most relevant information objects for a contextual segment are assigned to the contextual segment. | 03-28-2013 |
20130103634 | RECOMMENDATION SYSTEM - A recommendation system is disclosed that in one aspect offers item recommendations to users based on one or more items known to be liked by the users. An item may be recommended to a user if a similarity indicator for the item, established by determining how much more likely than expected the user will like the item based on the user liking another item, exceeds a predetermined threshold. Multiple items may be recommended to a user based on relative similarity indicators. | 04-25-2013 |
Monica Harit Shukla, Bangalore, IN US
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20110161854 | SYSTEMS AND METHODS FOR A SEAMLESS VISUAL PRESENTATION OF A PATIENT'S INTEGRATED HEALTH INFORMATION - Systems and methods provide visual presentation of clinical evidence to a user in association with a patient's anatomy. In certain examples, a patient information interface system to present an aggregated, graphical view of patient anatomy and history includes a data store to include images and patient history information and a processor to implement a user interface to accept user input. The processor provides a plurality of graphical representations of a human anatomy. Each graphical anatomy representation is to provide a view of a body system. Each graphical anatomy representation is to include one or more indicators corresponding to clinical events that have occurred in connection with a patient in the body system and are viewable through the graphical anatomy representation. Each of the one or more indicators is to be located at an anatomical location on the graphical representation affected by the clinical event corresponding to the indicator. | 06-30-2011 |
Nikunj M. Shukla, Lawrence, KS US
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20120294885 | TOLL-LIKE RECEPTOR-7 AND -8 MODULATORY 1H IMIDAZOQUINOLINE DERIVED COMPOUNDS - The present disclosure provides novel imidazoquinoline derived compounds, derivatives thereof, analogues thereof, and pharmaceutically acceptable salts thereof, and methods of making and using such compounds. The present disclosure also provides TLR7 agonists and TLR7/TLR8 dual agonists, probes, tissue-specific molecules, adjuvants, immunogenic compositions, therapeutic compositions, and self-adjuvanting vaccines including the imidazoquinoline derived compounds, derivatives thereof, analogues thereof, and pharmaceutically acceptable salts thereof. Derivatives of the imidazoquinoline derived compounds also include dendrimers and dimers of the imidazoquinoline derived compounds, and methods of making and using the dendrimeic and dimeric imidazoquinoline derived compounds. The present disclosure also provides dual TLR2/TLR7 hybrid agonists that include imidazoquinoline derived compounds of the present disclosure. | 11-22-2012 |
20140256922 | TOLL-LIKE RECEPTOR-7 AND -8 MODULATORY 1H IMIDAZOQUINOLINE DERIVED COMPOUNDS - The present disclosure provides novel imidazoquinoline derived compounds, derivatives thereof, analogues thereof, and pharmaceutically acceptable salts thereof, and methods of making and using such compounds. The present disclosure also provides TLR7 agonists and TLR7/TLR8 dual agonists, probes, tissue-specific molecules, adjuvants, immunogenic compositions, therapeutic compositions, and self-adjuvanting vaccines including the imidazoquinoline derived compounds, derivatives thereof, analogues thereof, and pharmaceutically acceptable salts thereof. Derivatives of the imidazoquinoline derived compounds also include dendrimers and dimers of the imidazoquinoline derived compounds, and methods of making and using the dendrimeic and dimeric imidazoquinoline derived compounds. The present disclosure also provides dual TLR2/TLR7 hybrid agonists that include imidazoquinoline derived compounds of the present disclosure. | 09-11-2014 |
Nisha Shukla, Pittsburgh, PA US
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20090197123 | Nano-Scaled Reactor for High Pressure and High Temperature Chemical Reactions and Chemical Ordering - A storage device includes a storage medium, a controller and a read/write head. The storage medium includes a substrate with a plurality of nano-structures arranged in an ordered pattern on a surface of the substrate. The controller is coupled to the storage medium. The controller has a read structure that extends over the substrate and a positioner adapted to adjust a position of the read structure relative to the substrate. The read/write head is mounted on the read structure and positioned over the substrate during operation. The read/write head is adapted to read and to write information to and from the plurality of nano-structures. | 08-06-2009 |
20100080895 | Method of producing self-assembled cubic FePt nanoparticles and apparatus using same - A method comprises: heating a solution of platinum acetylacetonate, Fe(CO) | 04-01-2010 |
20110086195 | Method Of Producing Self-Assembled Cubic FePt Nanoparticles And Apparatus Using Same - An apparatus includes a substrate, a magnetically soft underlayer on the substrate, and a plurality of generally cubic FePt nanoparticles on the magnetically soft underlayer, wherein the nanoparticles have a magnetization in a direction substantially normal to a surface of the magnetically soft underlayer. The FePt nanoparticles can have magnetically easy axes perpendicular to the surface of the soft underlayer. | 04-14-2011 |
Pavan K. Shukla, San Antonio, TX US
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20110221428 | Magnetostrictive Sensors for Surface Wave Testing of Thick Walled Structures - An ultrasonic probe that uses the magnetostrictive effect to generate and detect a surface-coupled guided wave for the purpose of inspecting a thick-walled structure for surface defects. A transmitter probe and a receiver probe are especially designed to generate and detect short wavelengths that will couple to only one surface of the plate. | 09-15-2011 |
20120038376 | Local Electrochemical Impedance Spectroscopy (LEIS) for Detecting Coating Defects in Buried Pipelines - A system and associated methods for acquiring and analyzing LEIS data from a buried structure, such as a pipeline. A special probe having adjustable electrodes is placed in the soil above the structure. A voltage is applied to the structure, causing more current to emanate from a coating defect than from intact coating. The probe electrodes acquire a response signal, which is analyzed to detect the defect. | 02-16-2012 |
Piyush Shukla, Greer, SC US
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20090246258 | Antimicrobial and odor adsorbing textile - The antimicrobial and odor adsorbing fabric substrate has a surface and at least a portion of the surface is coated with a finish. The finish contains a compound selected from the group consisting of silver particle-containing compounds, silver ion-containing compounds, silver ion-generating compounds, and any combinations thereof, a hyperbranched polyethyleneimine derivative, potassium citrate, inorganic chloride, a polyurethane binder, and a cross-linking agent. The silver-ion containing compound is selected from the group consisting of silver zirconium phosphate, silver zeolite, silver glass, and any mixtures thereof or a conductive silver containing nanoparticle. The hyperbranched polyethyleneimine derivative is of the formula: | 10-01-2009 |
Pradeep K. Shukla, Chicago, IL US
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20100311067 | DETECTION OF MATERNAL ALCOHOL EXPOSURE - The present invention provides methods, compositions, and systems for detecting in utero alcohol exposure by detecting expression level changes in certain biomarkers (e.g., in placental tissue). In certain embodiments, the biomarkers are selected from glucocorticoid receptor (GR), thyroid hormone receptor alpha (TRα), iodothyronine deiodinase III (Dio3) and G-protein α-subunit (Gsα). | 12-09-2010 |
Praveen Shukla, Burlington, MA US
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20150018579 | SYNTHESIS OF HIGH PURITY DMT-C3-DISULFIDE PHOSPHORAMIDITE - The 5′ and 3′-thiol modified oligonucleotides are attractive tools with a vast number of potential applications in the field of nucleic acid chemistry. There is a strong interest in developing new disulfide compounds or to optimize synthesis of existing disulfide modifiers, which are efficient in generating the 3′- or 5′-end reactive thiol group. Various synthetic protocols have been employed to synthesize pure 3-((3-(bis(4-dimethoxytrityl)propyl)di-sulfanyl)propyl 2-cyanoethyl diisopropylphosphoramidite (compound 2) starting from 3-(dimethoxytrityl)propyl)disulfanyl)pro-pan-1-ol, (compound 1). Herein, we describe an efficient, reproducible synthetic and purification protocol for target compound 2 from the compound 1. It is noteworthy that our reaction conditions were reproducible even at multi-gram scale (27 g) with a purity level as achieved in a small scale. | 01-15-2015 |
Praveen K. Shukla, Burlington, MA US
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20140142253 | Dithiolane Based Thiol Modifier For Labeling and Stronger Immobilization of Bio-Molecules On Solid Surfaces - The thiol modified oligonucleotides have vast number of applications in the field of nucleic acid chemistry. The conjugates generated by mono thiol groups are unstable at higher temperature, in high salt concentration buffers and in presence other thiols. There is strong need to develop a novel thiol modifier probes that can generate multiple thiol groups. Described herein are efficient processes and compounds, dithiolane phosphoramidites derivative and dithiolane succinyl supports. The advantage of our cyclic disulfide thiol modifier is multifold a) each incorporation introduces two thiol groups; b) it can be introduced at any desired site of oligonucleotides; c) The symmetrical branching nature of the spacer in the linker arm of dithiolane allows for clean oligo synthesis, where cleavage of the linker arm and thereby of loss of oligo chain is prevented. We have successfully made 20-mer oligonucleotide containing single dithiolane derivative at 3′, and 21-mer oligonucleotides containing single dithiolane derivative at 5′ or in the middle of the mixed base sequence. HPLC and ESI MS analysis of these oligonucleotides indicated satisfactory purity and correct composition of these oligos, respectively. | 05-22-2014 |
Rahul Parashar Shukla, King Of Prussia, PA US
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20090285887 | Pharmaceutical Composition Comprising A Plurality of Mini-Tablets Comprising A Factor XA Inhibitor - A modified release pharmaceutical composition for oral administration comprising plural mini-tablets, comprising a therapeutically effective amount of a Factor Xa inhibitor within a matrix of polymer(s). The mini-tablets are suitably encapsulated within a gelatin capsule. A manufacturing process and method of use are also described. | 11-19-2009 |
Rainy Shukla, Charlottesville, VA US
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20130213061 | ACTIVE CHILLED BEAM WITH STERILIZATION MEANS - An air-handling unit includes a primary air plenum and a primary air inlet in fluid communication with the primary air plenum. The primary air inlet is configured to provide a flow of primary air to the primary air plenum. The air-handling unit also includes a chamber in fluid communication with the primary air plenum. The chamber includes an irradiate cavity and a secondary air inlet configured to accept a flow of secondary air into the irradiate cavity, and a sterilization mechanism positioned in the irradiate cavity. The sterilization mechanism is configured to effectively treat and sterilize the secondary air. | 08-22-2013 |
Rajesh Shukla, Belle Meades, NJ US
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20110124848 | METALLOFULLERENE CONTRAST AGENTS - Endohedral metallofullerene compounds, which in water has a relaxivity of about 30 mM | 05-26-2011 |
Rajesh B. Shukla, Belle Mead, NJ US
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20120101475 | High Efficiency Auto-Injector - An auto-injector apparatus and associated methods utilizing specific dimensions and parameters of use for the auto-injector are provided for achieving increased effectiveness of the auto-injector device in delivering medicament into the patient's body, and in dispersion of the medicament from the initial injection site into the surrounding bodily tissues. | 04-26-2012 |
20150073383 | High Efficiency Auto-Injector - An auto-injector apparatus and associated methods utilizing specific dimensions and parameters of use for the auto-injector are provided for achieving increased effectiveness of the auto-injector device in delivering medicament into the patient's body, and in dispersion of the medicament from the initial injection site into the surrounding bodily tissues. | 03-12-2015 |
Rakesh Shukla, Needham, MA US
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20090150796 | SYSTEM FOR AND METHOD OF PROVIDING A USER INTERFACE FOR A COMPUTER-BASED SOFTWARE APPLICATION - A system for providing a graphical interface to a user includes a server platform and an operating system and application software running thereon. The system includes a client device capable of running a standard web browser that accesses the software application on the server platform for displaying information to the user in a display area on the client device. The web browser displays the information without requiring additional software to be installed, downloaded or run on the client device, and without requiring a scripting language to be enabled in the web browser on the client. The application software facilitates user manipulation of unstructured data in the display area for detailed inspection, and facilitates the user selectively causing to display annotations within the display area. The application software facilitates the user inserting annotations within the display area, thereby causing an action to occur in this system or an external system. | 06-11-2009 |
20140201612 | SYSTEM FOR AND METHOD OF PROVIDING A USER INTERFACE FOR A COMPUTER-BASED SOFTWARE APPLICATION - A system for providing a graphical interface to a user includes a server platform and an operating system and application software running thereon. The system includes a client device capable of running a standard web browser that accesses the software application on the server platform for displaying information to the user in a display area on the client device. The web browser displays the information without requiring additional software to be installed, downloaded or run on the client device, and without requiring a scripting language to be enabled in the web browser on the client. The application software facilitates user manipulation of unstructured data in the display area for detailed inspection, and facilitates the user selectively causing to display annotations within the display area. The application software facilitates the user inserting annotations within the display area, thereby causing an action to occur in this system or an external system. | 07-17-2014 |
Rameshwer Shukla, Ypsilanti, MI US
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20090088376 | DENDRIMER BASED COMPOSITIONS AND METHODS OF USING THE SAME - The present invention relates to novel therapeutic and diagnostic dendrimers. In particular, the present invention is directed to dendrimer based compositions and systems for use in disease diagnosis and therapy (e.g., cancer diagnosis and therapy). The compositions and systems comprise one or more components for targeting, imaging, sensing, and/or providing a therapeutic or diagnostic material and monitoring the response to therapy of a cell or tissue (e.g., a tumor). | 04-02-2009 |
Ravi Shukla, Columbia, MO US
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20090117045 | Soy or lentil stabilized gold nanoparticles and method for making same - The invention provides stabilized, biocompatible gold nanoparticles that are stabilized with material from soy or lentil plant material or a reactive extract thereof of the plant material. The gold nanoparticles of the invention can be fabricated with an environmentally friendly method for making biocompatible stabilized gold nanoparticles. In methods of the invention, an aqueous solution containing gold salts is mixed with soy or lentil plant material or a reactive extract thereof. In preferred embodiment methods of making, an aqueous solution containing gold salts is provided. The aqueous solution is mixed with soy or lentil plant material or a reactive extract thereof. The gold salts react to form biocompatible gold nanoparticles that are stabilized with a robust coating derived of the soy or lentil plant material or a reactive extract thereof. | 05-07-2009 |
20130129618 | EGCG STABILIZED GOLD NANOPARTICLES AND METHOD FOR MAKING SAME - The invention provides stabilized, biocompatible gold nanoparticles that are stabilized with material from epigallocatechin Gallate (EGCg), which is a polyphenols- or flavanoids-rich plant material that can be obtained from green tea. The EGCg is an an antioxidant reducing agent derived from green tea. The gold nanoparticles of the invention can be radioactive or non radioactive and are formed via a simple room temperature fabrication method. In preferred embodiment method of making, an aqueous solution containing gold salts is provided. The aqueous solution is mixed with EGCg in a buffer, such as deionized water. The gold salts react to form biocompatible gold nanoparticles that are stabilized with a coating of EGCg. The thermodynamically feasible redox couple of AuCl4-EGCg leading to the reduction of AuCl4- by EGCg to form gold nanoparticles. In another embodiment, pre-cooled gold salt and EGCg solutions form multi-layered EGCg coated particles. | 05-23-2013 |
20140050664 | SOY, LENTIL OR EXTRACT STABILIZED, BIOCOMPATIBLE GOLD NANOPARTICLES - The invention provides stabilized, biocompatible gold nanoparticles that are stabilized with material from soy or lentil plant material or a reactive extract thereof of the plant material. The gold nanoparticles of the invention can be fabricated with an environmentally friendly method for making biocompatible stabilized gold nanoparticles. The nanoparticles can be introduced in vivo to conduct enhanced imaging. The nanoparticles can also be introduced in vivo to conduct therapy. | 02-20-2014 |
Rishabhkumar Shukla, Scottsdale, AZ US
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20110060859 | Host-to-host software-based virtual system - A means for extending the Input/Output System of a host computer via software-centric virtualization. Physical hardware I/O resources are virtualized via a software-centric solution utilizing two or more host systems. The invention advantageously eliminates the host bus adapter, remote bus adapter, and expansion chassis and replaces them with a software construct that virtualizes selectable hardware resources located on a geographically remote second host making them available to the first host. One aspect of the invention utilizes | 03-10-2011 |
Rishi Shukla, Indianapolis, IN US
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20090178928 | Process for Desalting Glycerol Solutions and Recovery of Chemicals - Processes for desalting glycerol-rich solutions or process streams using electrodialysis are provided. The glycerol-rich process streams are typically byproducts from the production of biodiesel. Following electrodialysis, the resulting aqueous salt solution is placed in a water splitting cell to recover the acid and base components of the salt. These acid and base components, in turn, can be reused in other processes, such as biodiesel production. | 07-16-2009 |
Rishi Shukla, Decatur, IL US
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20080317888 | PROCESS FOR OBTAINING LIGNANS - Process for obtaining lignan from plant material by extraction with an extraction solvent and separation of the liquid fraction from the plant material. The separated liquid fraction containing the lignan product is subjected to further processing to remove cyanogenic sugars and other impurities. The resulting lignan containing product may be formulated for the treatment of various conditions, such as cancer, diabetes, hypertension, lupus, and atherosclerosis. | 12-25-2008 |
Salil Shukla, Farmington Hills, MI US
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20120307040 | TECHNIQUE FOR CYLINDRICAL PART INNER SURFACE INSPECTION - A system and method for inspecting inner surfaces ( | 12-06-2012 |
Sanjay Shukla, Hendersonville, TN US
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20090134143 | ELECTRONIC POWER CONTROL FOR COOKTOP HEATERS - An electronic cook top control system has a cooktop including a heating element. An electronic controller is operatively connected to the cooktop. A rotary position input is operatively connected to the electronic controller. The electronic controller controls a heating level of the cooktop in a first manner in response to rotation of the rotary position input in a first direction. The electronic controller controls the heating level of the cooktop in a second manner in response to rotation of the rotary position input in a second direction. | 05-28-2009 |
Satwik Shukla, Austin, TX US
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20140306986 | Identifying Content in Electronic Images - In one embodiment, a method includes accessing an electronic image comprising a surface area and dividing the electronic image into a plurality of surfaces. The method further includes determining that one or more of the surfaces comprise a type of graphics, and determining a percentage of the surface area of the image that is occupied by the one or more surfaces determined to comprise the type of graphics. | 10-16-2014 |
Satyajit Shukla, Orlando, FL US
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20090252669 | SYNTHESIS OF TETRAGONAL PHASE STABILIZED NANO AND SUBMICRON SIZED NANOPARTICLES - Novel, monodispersed, spherical ZrO | 10-08-2009 |
Satyajit V. Shukla, Orlando, FL US
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20100212403 | Room Temperature Hydrogen Sensor - A sensor for selectively determining the presence and measuring the amount of hydrogen in the vicinity of the sensor. The sensor comprises a MEMS device coated with a nanostructured thin film of indium oxide doped tin oxide with an over layer of nanostructured barium cerate with platinum catalyst nanoparticles. Initial exposure to a UV light source, at room temperature, causes burning of organic residues present on the sensor surface and provides a clean surface for sensing hydrogen at room temperature. A giant room temperature hydrogen sensitivity is observed after making the UV source off. The hydrogen sensor of the invention can be usefully employed for the detection of hydrogen in an environment susceptible to the incursion or generation of hydrogen and may be conveniently used at room temperature. | 08-26-2010 |
Saurabh Shukla, Morrisville, NC US
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20090106270 | System and Method for Maintaining Persistent Links to Information on the Internet - A method, system and computer-usable medium are disclosed for maintaining persistent links to information stored on a network. Information elements are tagged and their original network location is saved as a hyperlink. The tagged information elements are then acquired at the original network location by a search engine crawler, indexed by a search engine, and stored in an information location index. The tagged information elements are periodically submitted to the search engine to generate search results. Comparison operations are performed to determine the search results comprising the closest-matching information elements and their current network location. The network location stored in the hyperlink is replaced with the current network location if it is not the same. | 04-23-2009 |
Shunashep Shukla, Houston, TX US
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20140182850 | PROCESS FOR PRODUCING OIL - Heavy oil or bitumen is recovered by injecting an oil recovery formulation comprising ammonia and steam having a vapor quality of from greater than 0 to less than 0.7, or injecting components thereof, into an underground oil-bearing formation comprising oil or bitumen having a total acid number of at least 0.1 and producing oil or bitumen from the formation after injection of the oil recovery formulation, or components thereof, into the formation. | 07-03-2014 |
Sunil K. Shukla, Tarry Town, NY US
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20130318290 | Garbage Collection Implemented in Hardware - A computing device is provided and includes a memory module, a sweep engine, a root snapshot module, and a trace engine. The memory module has a memory implemented as at least one hardware circuit. The memory module uses a dual-ported memory configuration. The sweep engine includes a stack pointer. The sweep engine is configured to send a garbage collection signal if the stack pointer falls below a specified level. The sweep engine is in communication with the memory module to reclaim memory. The root snapshot engine is configured to take a snapshot of roots from at least one mutator if the garbage collection signal is received from the sweep engine. The trace engine receives roots from the root snapshot engine and is in communication with the memory module to receive data. | 11-28-2013 |
20130318315 | Garbage Collection Implemented in Hardware - A method of garbage collection in a computing device is provided. The method includes providing a memory module having a memory implemented as at least one hardware circuit. The memory module uses a dual-ported memory configuration. The method includes triggering a garbage collection signal by a sweep engine of the computing device. The sweep engine is in communication with a memory module to reclaim memory. The method includes receiving the garbage collection signal by a root snapshot engine of the computing device. The method includes taking a snapshot of roots from at least one mutator by the root snapshot engine if the garbage collection signal is received. The method includes receiving roots from the root snapshot engine by a trace engine of the computing device. The trace engine is in communication with the memory module to receive data. | 11-28-2013 |
Sunil K. Shukla, Tarrytown, NY US
Patent application number | Description | Published |
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20130268907 | BEST CLOCK FREQUENCY SEARCH FOR FPGA-BASED DESIGN - Searching for desired clock frequency for integrated circuit-based design may receive timing result of a hardware synthesis job executed based on a code specifying hardware design. One or more different timing constraints specifying respective one or more different clock frequencies than used in the hardware synthesis job may be automatically generated without modifying the code. One or more instances of the hardware synthesis job to run with the respective one or more different timing constraints may be automatically spawned. The automatic generation and spawning may repeat until a termination criterion is met, and/or a desired successful timing constraint is identified for the hardware design from the different timing constraints based on whether the one or more instances of the hardware synthesis job met their respective timing constraints. | 10-10-2013 |
20130346930 | BEST CLOCK FREQUENCY SEARCH FOR FPGA-BASED DESIGN - Searching for desired clock frequency for integrated circuit-based design may receive timing result of a hardware synthesis job executed based on a code specifying hardware design. One or more different timing constraints specifying respective one or more different clock frequencies than used in the hardware synthesis job may be automatically generated without modifying the code. One or more instances of the hardware synthesis job to run with the respective one or more different timing constraints may be automatically spawned. The automatic generation and spawning may repeat until a termination criterion is met, and/or a desired successful timing constraint is identified for the hardware design from the different timing constraints based on whether the one or more instances of the hardware synthesis job met their respective timing constraints. | 12-26-2013 |
20140208299 | COMMUNICATION STACK FOR SOFTWARE-HARDWARE CO-EXECUTION ON HETEROGENEOUS COMPUTING SYSTEMS WITH PROCESSORS AND RECONFIGURABLE LOGIC (FPGAs) - A communication stack for software-hardware co-execution on heterogeneous computing systems with processors and reconfigurable logic, in one aspect, may comprise a crossbar operable to connect hardware user code and functioning as a platform independent communication layer. A physical interface interfaces to the reconfigurable logic. A physical interface bridge is connected to the cross and the physical interface. The physical interface bridge connects the crossbar and the physical interface via a platform specific translation layer specific to the reconfigurable logic. The crossbar, the physical interface, and the physical interface bridge may be instantiated in response to the hardware user code being generated, the crossbar instantiated with associated parameters comprising one or more routes and associated data widths. The hardware user code is assigned a unique virtual route in the crossbar. | 07-24-2014 |
20140208300 | COMMUNICATION STACK FOR SOFTWARE-HARDWARE CO-EXECUTION ON HETEROGENEOUS COMPUTING SYSTEMS WITH PROCESSORS AND RECONFIGURABLE LOGIC (FPGAs) - A communication stack for software-hardware co-execution on heterogeneous computing systems with processors and reconfigurable logic, in one aspect, may comprise a crossbar operable to connect hardware user code and functioning as a platform independent communication layer. A physical interface interfaces to the reconfigurable logic. A physical interface bridge is connected to the cross and the physical interface. The physical interface bridge connects the crossbar and the physical interface via a platform specific translation layer specific to the reconfigurable logic. The crossbar, the physical interface, and the physical interface bridge may be instantiated in response to the hardware user code being generated, the crossbar instantiated with associated parameters comprising one or more routes and associated data widths. The hardware user code is assigned a unique virtual route in the crossbar. | 07-24-2014 |
Susmita Shukla, Glastonbury, CT US
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20120096384 | SYSTEMS AND METHODS FOR AN INTERACTIVE GRAPHICAL USER INTERFACE FOR DEPICTING STATUS OF A CLAIM - Systems and methods for an interactive graphical user interface for depicting the status of a claim are provided. The system includes a database for storing claim data and a server in communication with the database. The stored claim data includes a claim workflow associated the claim. The workflow defines the processing steps associated with processing the claim. The server receives a user request to check the status of the claim. The server determines status data of the claim based on stored claim data and outputs the status data to a graphical user interface for depicting a graphical representation of the status data. The graphical representation includes a timeline corresponding to the workflow of the claim and a progress bar indicative of the status of the claim. | 04-19-2012 |
20140019168 | SYSTEMS AND METHODS FOR GRAPHICAL REPRESENTATION OF STATUS OF AN INSURANCE CLAIM - Systems and methods for an interactive graphical user interface for depicting the status of a claim are provided. The system includes a database for storing claim data and a server in communication with the database. The stored claim data includes a claim workflow associated the claim. The workflow defines the processing steps associated with processing the claim. The server receives a user request to check the status of the claim. The server determines status data of the claim based on stored claim data and outputs the status data to a graphical user interface for depicting a graphical representation of the status data. The graphical representation includes a timeline corresponding to the workflow of the claim and a progress bar indicative of the status of the claim. | 01-16-2014 |
Triveni P. Shukla, Mukwonago, WI US
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20140017376 | Bio-based Fiber Gums (BFGs) and Processes for Producing BFGs - Processes for the preparation of bio-based fiber gums and products produced by these processes and some of their uses. | 01-16-2014 |
Umesh Shukla, Belle Mead, NJ US
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20090118258 | COMBINATION THERAPY COMPRISING ANGIOTENSIN CONVERTING ENZYME INHIBITORS AND VASOPRESSIN RECEPTOR ANTAGONISTS - The present invention relates to certain pharmaceutical compositions containing at least one vasopressin receptor antagonist and at least one angiotensin converting enzyme (ACE) inhibitor and methods for preparing these compounds, compositions, intermediates and derivatives thereof and for the treatment of vasopressin and/or angiotensin converting enzyme mediated disorders. | 05-07-2009 |
20090311344 | Dosing Regimen - The present invention provides a method for treating hematological disorders such as anemia and thrombocytopenia, whereby a TPO mimetic peptide compound is administered using a specified dosing regimen. The dosing regimen involves the administration of the TPO mimetic peptide compound within a specified time frame surrounding administration of a chemotherapeutic agent. The dosing regimen also involves monitoring subject response in order to determine future course of treatment. | 12-17-2009 |
20100093701 | COMBINATION THERAPY COMPRISING ANGIOTENSIN RECEPTOR BLOCKERS AND VASOPRESSIN RECEPTOR ANTAGONISTS - The present invention relates to certain pharmaceutical compositions containing at least one vasopressin receptor antagonist and at least one angiotensin receptor blocker (ARB) and methods for preparing these compounds, compositions, intermediates and derivatives thereof and for the treatment of vasopressin and/or angiotensin-mediated disorders. | 04-15-2010 |
Vidyanand G. Shukla, Boston, MA US
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20090306016 | FATTY ACID AMIDE HYDROLASE INHIBITORS - Disclosed are compounds of formula R—X—Y that may be used to inhibit the action of fatty acid amide hydrolase (FAAH). Inhibition of fatty acid amide hydrolase (FAAH) will slow the normal degradation and inactivation of endogenous cannabinoid ligands by FAAH hydrolysis and allow higher levels of those endogenous cannabinergic ligands to remain present. These higher levels of endocannabinoid ligands provide increased stimulation of the cannabinoid CB1i and CB2 receptors and produce physiological effects related to the activation of the cannabinoid receptors. They will also enhance the effects of other exogenous cannabinergic ligands and allow them to produce their effects at lower concentrations as compared to systems in which fatty acid amide hydrolase (FAAH) action is hot inhibited. Thus, a compound that inhibits the inactivation of endogenous cannabinoid ligands by fatty acid amide hydrolase (FAAH) may increase the levels of endocannabinoids and, thus, enhance the activation of cannabinoid receptors. Thus, the compound may not directly modulate the cannabinoid receptors but has the effect of indirectly stimulating the cannabinoid receptors by increasing the levels of endocannabinoid ligands. It may also enhance the effects and duration of action of other exogenous cannabinergic ligands that are administered in order to elicit a cannabinergic response. | 12-10-2009 |
20110039874 | MONOACYLGLYCEROL LIPASE INHIBITORS FOR MODULATION OF CANNABINOID ACTIVITY - Disclosed are compounds and compositions that inhibit the action of monoacylglycerol lipase (MGL) and fatty acid amide hydrolase (FAAH), methods of inhibiting MGL and FAAH, methods of modulating cannabinoid receptors, and methods of treating various disorders related to the modulation of cannabinoid receptors. | 02-17-2011 |
20110071178 | Methods and Compounds for Modulating Cannabinoid Activity - Disclosed are compounds and compositions that inhibit the action of monoacylglycerol lipase (MGL) and fatty acid amide hydrolase (FAAH), methods of inhibiting MGL and FAAH, methods of modulating cannabinoid receptors, and methods of treating various disorders related to the modulation of cannabinoid receptors. | 03-24-2011 |
Vijay Shukla, Highland Park, NJ US
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20090045634 | LINEAR WIND-POWERED ELECTRIC GENERATOR - A linear wind powered electric generator (LWPEG), which is particularly adapted for installation at geographical sites subject to lower wind intensities. More specifically, there are provided design concepts for an LWPEG, possessing reasonable economic parameters for utilization at the lower-intensity wind sites. Moreover, the linear wind powered electric generator is based on a track based wind power generator, incorporating aerodynamic designs, which are adapted to reduce mechanical complexities presently encountered in this technology, while being cost-effective both in construction and in connection with the operation thereof. | 02-19-2009 |
20110115231 | HYDROKINETIC ENERGY CONVERSION SYSTEM - A hydrokinetic energy conversion system (HKECS) is provided, comprising design configurations suitable for efficient production of tidal or river in-stream kinetic energy into useful mechanical energy for tasks such as generating electricity or water pumping. The apparatus includes a set of blades with an airfoil cross sectional contour moving on a horizontal or vertical closed loop track, whereby the blades are propelled through the water by a net tangential lift force, rather than drag, to effectively convert the kinetic energy of flowing water to useful power. | 05-19-2011 |
20120313269 | Shrouded-Plasma Process and Apparatus for the Production of Metastable Nanostructured Materials - A method and apparatus for producing metastable nanostructured materials employing a ceramic shroud surrounding a plasma flame having a steady state reaction zone into which an aerosol or liquid jet of solution precursor or powder material is fed, causing the material to be pyrolyzed, melted, or vaporized, followed by quenching to form a metastable nanosized powder that has an amorphous (short-range ordered), or metastable microsized powder that has a crystalline (long-range ordered) structure, respectively. | 12-13-2012 |
20120318261 | Valved Holding Chamber With Whistle for the Administration of Inhalable Drugs - This invention discloses a chamber adapted for the administration of medication from a source of aerosolized drug, such as a metered dose inhaler (MDI) or nebulizer, comprising a conduit with an oval cross section, a mounting for the MDI at the rear, an annular one-way valve at the front in fluid communication with the inhalation airway of the patient that permits air to flow out of the chamber during an inhalation by the patient, but prevents exhaled air from entering the chamber, an exhaust valve in the front section that provides an effective seal during inhalation, and a solid state whistle, wherein the whistle is adapted to making a sound if the air pressure within the chamber is below a predefined threshold. The inventive chamber may be used to directly administer inhaled medication to the mouth of a patient, or it may be used with an inhalation mask. | 12-20-2012 |
20120318265 | Mask for the administration of inhaled drugs - A breathing mask for use in administering inhalable medications to a patient in need of an inhaled drug is provided. The mask disclosed herein is particularly useful for use with very young children. The mask is made from a flexible molded plastic silicone or elastomeric material, and has an anthropometrically/anatomically/ergonomically contoured shape to provide a good seal, a comfortable fit, and minimal dead space within the mask. The airway is aligned with nose. There may be an orifice for use with a soother device to calm a child using the mask. Also provided is a visual flow indicator to provide an indication of the quality of the seal of the mask on the face. | 12-20-2012 |
Vinay H. Shukla, Columbus, OH US
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20120003314 | DELAYED-RELEASE ORAL PHARMACEUTICAL COMPOSITION FOR TREATMENT OF COLONIC DISORDERS - A timed or delayed release oral composition delivery system for the treatment of colonic disorders and diseases is provided. According to one aspect, a delayed release oral pharmaceutical composition includes an active core comprising a therapeutically effective amount of 5-amino salicylic acid (i.e., mesalamine); a primary coating composition disposed around the active core, wherein the primary coating composition includes an enteric polymer; and a secondary coating composition disposed around the primary coating composition, wherein the secondary coating composition includes a ratio mixture of ethyl cellulose and hydroxypropyl methylcellulose. | 01-05-2012 |
Vinay H. Shukla, Hilliard, OH US
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20090169622 | DELAYED-RELEASE ORAL PHARMACEUTICAL COMPOSITION FOR TREATMENT OF COLONIC DISORDERS - A timed or delayed release oral composition delivery system for the treatment of colonic disorders and diseases is provided. According to one aspect, a delayed release oral pharmaceutical composition includes an active core comprising a therapeutically effective amount of 5-amino salicylic acid (i.e., mesalamine); a primary coating composition disposed around the active core, wherein the primary coating composition includes an enteric polymer; and a secondary coating composition disposed around the primary coating composition, wherein the secondary coating composition includes a ratio mixture of ethyl cellulose and hydroxypropyl methylcellulose. | 07-02-2009 |
Vipula Shukla, Indianapolis, IN US
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20130326725 | TARGETED MODIFICATION OF MALATE DEHYDROGENASE - Disclosed herein are methods and compositions for targeted modification of one or more endogenous plant malate dehydrogenase genes. | 12-05-2013 |
Vipula K. Shukla, Indianapolis, IN US
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20090111188 | Optimized non-canonical zinc finger proteins - Disclosed herein are zinc fingers comprising CCHC zinc coordinating residues. Also described are zinc finger proteins and fusion proteins comprising these CCHC zinc fingers as well as polynucleotides encoding these proteins. Methods of using these proteins for gene editing and gene regulation are also described. | 04-30-2009 |
20100199389 | Targeted integration into the Zp15 locus - Disclosed herein are methods and compositions for targeted integration of an exogenous sequence into a plant Zp15 locus, for example, for expression of a polypeptide of interest. | 08-05-2010 |
Vipula Kiran Shukla, Indianapolis, IN US
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20090320159 | Nucleic acid compositions conferring disease resistance - This invention encompasses the identification and isolation of genes that confer disease control properties in plants, as well as plants comprising such genes. These genes are derived from the following sources: | 12-24-2009 |
20110119786 | INOSITOL POLYPHOSPHATE 2-KINASE GENES AND USES THEREOF - This invention relates to newly identified polynucleotides and polypeptides in the phytic acid biosynthetic pathways, variants and derivatives of the same; methods for making the polynucleotides, polypeptides, variants, derivatives and antagonists. In particular, the invention relates to polynucleotides encoding inositol polyphosphate 2-kinase (IPP2-K) and polypeptides exhibiting such activity to modulate the phytic acid biosynthesis in such a way as to decrease phytic acid and/or increase the non-phytic acid phosphorous, especially in corn or soy animal feedstuffs. | 05-19-2011 |
Vishnu Shukla, Dover, MA US
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20100235423 | PRESENCE NETWORK AGENT IN IMS NETWORKS - A system determines presence updates associated with presence user agents (PUAs), where the presence updates indicate changes in a presence status associated with each of the PUAs. The system further determines an application type associated with each of the PUAs and routes the presence updates to respective presence network agents (PNAs) based on the determined application type. | 09-16-2010 |