Palermo, US
Adam T. Palermo, Philadelphia, PA US
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20150230764 | DOSE-REDUCING X-RAY AIMING DEVICE - A dose-reducing x-ray aiming device includes an aiming ring having shield with an aperture, at least one arm, and at least one sensor holder. The dose-reducing x-ray aiming ring is generally used to aim a dental x-ray machine and at least partially shield some of the x-rays emitted from the x-ray machine while capturing radiographs. X-rays generally pass through the aperture and then interact with a sensor for capturing the radiographs after passing through the tissue of a patient. In one embodiment, the x-ray aiming device provides an all-in-one aiming ring, which allows a user to capture both periapical and bitewing radiographs with a single device. The aiming device also includes an annular ridge or lip which helps align the x-ray machine with the aiming device. | 08-20-2015 |
Alex Palermo, Davie, FL US
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20080202014 | KITE FISHING LURE THAT GENERATES A SPLASHING EFFECT ON A BODY OF WATER - A fishing lure that generates a splashing effect when deployed in a body of water and attached to a kite fishing assembly. This splashing effect attracts target fish in the same manner that live bait does. Different optional features can be included in the kite fishing lure. One option is to include a chemical concavity configured to store a chemical substance that is dispersed into the body of water in concentrations designed to attract proximate located fish. Another option is to include a movement simulator designed to simulate movement of a struggling bait fish. Yet another option is to include a replaceable skin sheaf designed to be periodically replaced after being worn from repetitive usage. | 08-28-2008 |
Anthony Palermo, Gibsonia, PA US
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20110037013 | COATINGS COMPRISING ITACONATE LATEX PARTICLES AND METHODS FOR USING THE SAME - Coatings comprising a latex particle comprising the reaction product of itaconic acid/anhydride and a monoalcohol, a monoepoxide, a monoamine or mixtures thereof are disclosed. Methods for using such coatings, particularly for inhibiting sound and/or vibration transmission through a substrate, are also disclosed. | 02-17-2011 |
Brian Palermo, Dryden, NY US
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20080230665 | VEHICLE BED RAINGUTTER BRACKET FOR RACK SYSTEM - A mounting bracket for securing a raingutter-mountable roof rack system to the bed or cargo management rail of a pickup truck or SUV. The bracket comprises a simple device with a minimal number of parts required for removably clamping the bracket to the side member of a vehicle bed. The bracket is simple to install, may be located anywhere along the side of the vehicle bed, and does not require the presence of a bed cover system for attachment to the vehicle. The bracket attaches to the side of the vehicle's bed in a manner that does not consume a substantial amount of space within the bed of the vehicle, and it may be used in conjunction with a tonneau cover without interfering with the operation of the cover. | 09-25-2008 |
20100162671 | PURIFICATION ASSEMBLIES, PURIFICATION UNITS, AND METHODS OF ASSEMBLING PURIFICATION ASSEMBLIES - A purification assembly ( | 07-01-2010 |
20110041470 | FLUID ASSEMBLIES COMPRISING A PURIFICATION ELEMENT - This invention relates to a fluid assembly comprising a fluid handling device ( | 02-24-2011 |
20120168585 | VEHICLE BED RAINGUTTER BRACKET FOR RACK SYSTEM - A mounting bracket for securing a raingutter-mountable roof rack system to the bed or cargo management rail of a pickup truck or SUV. The bracket comprises a simple device with a minimal number of parts required for removably clamping the bracket to the side member of a vehicle bed. The bracket is simple to install, may be located anywhere along the side of the vehicle bed, and does not require the presence of a bed cover system for attachment to the vehicle. The bracket attaches to the side of the vehicle's bed in a manner that does not consume a substantial amount of space within the bed of the vehicle, and it may be used in conjunction with a tonneau cover without interfering with the operation of the cover. | 07-05-2012 |
Brian Anthony Palermo, Dryden, NY US
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20150113925 | FILTER MANIFOLD - A filter manifold is provided for filtering particulates in fluid and gas streams. The filter manifold seals the inlet and outlet valves in a closed position until a filter capsule is loaded into a carriage assembly. The inlet and outlet valves are opened only when a filter capsule is properly loaded into the carriage assembly. | 04-30-2015 |
Christine Palermo, Rochester, NY US
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20120165403 | METHODS OF INHIBITING THE ACTIVITY OF HSP90 AND/OR ARYL HYDROCARBON RECEPTOR - The present invention relates to a method of screening compounds for binding to hsp90 by exposing a compound to hsp90 or a polypeptide fragment thereof containing amino acid residues 538-728 of the full length protein and determining whether the compound binds to hsp90 of the polypeptide fragment thereof. Also disclosed is a method of screening compounds for inhibition of hsp90 activity. The present invention further relates to a method of screening compounds as a cancer therapeutic and a method of treating cancerous conditions. Also disclosed is a method of inhibiting transcription-inducing activity of an aryl hydrocarbon receptor in a cell and a method of modifying expression of a gene that is activated by an aryl hydrocarbon receptor. | 06-28-2012 |
David Palermo, Pittsburgh, PA US
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20150300784 | ARMOR MOUNTING SYSTEM AND ARMOR INCORPORATING THE SAME - A modular armor system configured to be readily attached and detached from a frame surrounding a window in a vehicle or other structure, such as a building. The modular armor system may be configured to provide any desired ballistics protection rating. In one embodiment, the modular armor system includes a ballistics-grade armor panel having an outer strike face and an inner surface opposite the outer strike face. The modular armor system also includes a fastener coupled to the ballistics-grade armor panel. The fastener is configured to detachably couple the ballistics-grade armor panel to the frame surrounding the window in the vehicle or other structure. | 10-22-2015 |
20150377595 | REDUCED WEIGHT ARMOR SYSTEMS AND METHODS OF MANUFACTURING THE SAME - An armor system configured to be coupled to a frame surrounding a window in a vehicle or other structure, such as a building. The armor system may be configured to provide any desired ballistics protection rating. The armor system includes a ballistics-grade armor panel and at least one insert embedded in the ballistics-grade armor panel. The insert extends around at least a portion of a periphery of the ballistics-grade armor panel. The one or more inserts may be configured to reduce the parasitic weight of the armor system. | 12-31-2015 |
Francis X. Palermo, Reno, NV US
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20080208287 | Electrical stimulation device and method for the treatment of neurological disorders - An electrical stimulation system and method for the treatment of neurological disorders is disclosed. In a preferred embodiment, the electrical stimulation system includes channels of electrodes positioned in electrical contact with tissue of a neuromuscular target body region of a patient to provide pattered neuromuscular stimulation to the patient's musculature. In addition, at least one electrode from a channel is positioned in electrical contact with a tissue of the motor control region of the brain. A series of patterned electrical pulses are then applied to the patient through the channels to provide peripheral neuromuscular stimulation, and a direct current is applied transcranially to the brain. Various exemplary embodiments of the invention are disclosed. | 08-28-2008 |
20150290457 | ELECTRICAL STIMULATION DEVICE AND METHOD FOR THE TREATMENT OF NEUROLOGICAL DISORDERS - An electrical stimulation system and method for the treatment of neurological disorders is disclosed. In a preferred embodiment, the electrical stimulation system includes channels of electrodes positioned in electrical contact with tissue of a neuromuscular target body region of a patient to provide pattered neuromuscular stimulation to the patient's musculature. In addition, at least one electrode from a channel is positioned in electrical contact with a tissue of the motor control region of the brain. A series of patterned electrical pulses are then applied to the patient through the channels to provide peripheral neuromuscular stimulation, and a direct current is applied transcranially to the brain. Various exemplary embodiments of the invention are disclosed. | 10-15-2015 |
Francis X. Palermo, Boulder, CO US
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20140005745 | ELECTRICAL STIMULATION METHOD FOR REDUCTION OF JOINT COMPRESSION | 01-02-2014 |
Francis X. Palermo, Lafayette, CO US
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20090326607 | Electrical Stimulation Method for Treatment of Peripheral Neuropathy - An electrical stimulation method for the treatment of peripheral neuropathy is disclosed. In a preferred embodiment, the method utilizes an electrical stimulation device that includes a plurality of channels of electrodes each of which includes a first and second electrode positioned in electrical contact with tissue of a target region suffering from peripheral neuropathy. Agonist/antagonist muscles involved in abduction/adduction, flexion/extension, supination/pronation, protraction/retraction, and/or eversion/inversion in the peripheral body regions are stimulated with a patterned series of electrical pulses through channels of electrodes in accordance with a procedure for treating peripheral neuropathy. The patterned series of electrical pulses may comprise: a plurality of cycles of a biphasic sequential pulse train pattern; a plurality of cycles of a biphasic overlapping pulse train pattern; a plurality of cycles of a triphasic sequential pulse train pattern; and a plurality of cycles of a triphasic overlapping pulse train pattern. | 12-31-2009 |
20110224753 | Electrical Stimulation Device and Method for the Treatment of Neurological Disorders - An electrical stimulation system and method for the treatment of neurological disorders is disclosed. In a preferred embodiment, the electrical stimulation system includes channels of electrodes positioned in electrical contact with tissue of a neuromuscular target body region of a patient to provide pattered neuromuscular stimulation to the patient's musculature. In addition, at least one electrode from a channel is positioned in electrical contact with a tissue of the motor control region of the brain. A series of patterned electrical pulses are then applied to the patient through the channels to provide peripheral neuromuscular stimulation, and a direct current is applied transcranially to the brain. Various exemplary embodiments of the invention are disclosed. | 09-15-2011 |
Frank Palermo, Lafayette, CO US
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20090319003 | Electrical Stimulation Method for Reduction of Joint Compression - An electrical stimulation method for the reduction of joint compression is disclosed. In a preferred embodiment, the method utilizes an electrical stimulation device that includes a plurality of channels of electrodes each of which includes at least a first and second electrode positioned in electrical contact with tissue of at least two muscles crossing a joint. Agonist/antagonist muscles involved in abduction/adduction, flexion/extension, supination/pronation, protraction/retraction, and/or eversion/inversion of body regions via joint movement are stimulated with a patterned series of electrical pulses through channels of electrodes in accordance with a procedure for reducing joint compression. The patterned series of electrical pulses may comprise: a plurality of cycles of a biphasic sequential pulse train pattern; a plurality of cycles of a biphasic overlapping pulse train pattern; a plurality of cycles of a triphasic sequential pulse train pattern; and a plurality of cycles of a triphasic overlapping pulse train pattern. | 12-24-2009 |
Gianpiero D. Palermo, New York, NY US
James Palermo, Cherry Hill, NJ US
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20160049040 | Method and Machine of Enhancing Play of a Slot-Type Game with Expanding Top Symbols - A gaming machine and method of play providing a predetermined top game symbol that can replace adjacent symbols to expand possible winning outcomes and payouts for winning outcomes in connection with a “ways to win” game format. The machine and method defining an expanding property applicable to the top symbol, and where the top symbol and expanding property are displayed together in the same game position, the top symbol being propagated to replace other symbols presented on the same reel. A configuration of identical game symbols on displayable game positions of adjacent reels establishing winning outcomes and payouts. | 02-18-2016 |
James Palermo, Chicago, IL US
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20110287823 | CONTROLLING BINGO GAME INTERACTIVITY - A wagering game system and its operations are described herein. In some embodiments, the operations can include providing gaming content for use during a bingo game, where the gaming content includes a representation of a bingo game card that includes card identifiers, arranged in a distinct pattern, which are usable during the bingo game to track game identifiers, with equivalent values, when drawn during the bingo game. The operations can further include selecting a card identifier, in response to user input, which indicates a user prediction that a corresponding game identifier, with an equivalent value, will be drawn during the bingo game. The operations can further include placing a bet for a secondary wagering game on the selecting of the card identifier, detecting a draw of the corresponding game identifier during the bingo game, and using the draw of the game identifier as an outcome for the bet. | 11-24-2011 |
20110300926 | PRESENTING GROUP WAGERING GAMES AND AWARDS - A wagering game system and its operations are described herein. In embodiments, the operations can include monitoring wagering game play for a player account that is registered to play a group scavenger hunt game. The group scavenger hunt game may include various collectable items that group members collect to win the group scavenger hunt game. The operations can further include determining that wagering game events occur during the wagering game play, where the occurrences of the wagering game events are prerequisites for obtaining the collectable items. The operations can further include indicating on a group progress report (e.g., a website) that one of the collectable items was obtained. In some embodiments, the operations can also include awarding the player account for obtaining the item, providing trophies, or other virtual assets, for winning the group scavenger hunt game, providing benefits for holding the trophies, etc. | 12-08-2011 |
20120115591 | AWARDING ACHIEVEMENTS IN WAGERING GAMES - A wagering game system and its operations are described herein. In embodiments, the operations can include determining possible wagering game events that can occur for a wagering game. The operations can further include determining a subset of the possible wagering game events and configuring an award ladder game to award prizes in a stair-step fashion based on occurrence of the subset of possible wagering game events. The operations can further include ordering a plurality of awards, or prizes, on an award ladder in an order of value and configuring the award ladder to award the plurality of awards in a sequential order of value according to an order of occurrence of the subset of possible wagering game events. The operations can further include configuring the award ladder to reset when the plurality of awards have been awarded. | 05-10-2012 |
20130059651 | AWARDING ACHIEVEMENTS IN WAGERING GAMES - A wagering game system and its operations are described herein. In embodiments, the operations can include determining possible wagering game events that can occur for a wagering game. The operations can further include determining a subset of the possible wagering game events and configuring an award ladder game to award prizes in a stair-step fashion based on occurrence of the subset of possible wagering game events. The operations can further include ordering a plurality of awards, or prizes, on an award ladder in an order of value and configuring the award ladder to award the plurality of awards in a sequential order of value according to an order of occurrence of the subset of possible wagering game events. The operations can further include configuring the award ladder to reset when the plurality of awards have been awarded. | 03-07-2013 |
James V. Palermo, Chic, IL US
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20100130280 | MULTI-PLAYER, MULTI-TOUCH TABLE FOR USE IN WAGERING GAME SYSTEMS - A multi-player gaming system sensing multiple simultaneous contacts on a surface of a gaming table, differentiating contacts by different players. Privacy controls selectively display private information visible to only one of the players on or near the display surface of the gaming table. The gaming system also detects physical objects placed on the surface of the gaming table, causing wagering game functions or peripheral functions to be performed as a result of the placement of the object on the display surface. | 05-27-2010 |
20120157193 | MULTI-PLAYER, MULTI-TOUCH TABLE FOR USE IN WAGERING GAME SYSTEMS - A multi-player gaming system sensing multiple simultaneous contacts on a surface of a gaming table, differentiating contacts by different players. Privacy controls selectively display private information visible to only one of the players on or near the display surface of the gaming table. The gaming system also detects physical objects placed on the surface of the gaming table, causing wagering game functions or peripheral functions to be performed as a result of the placement of the object on the display surface. | 06-21-2012 |
James V. Palermo, Chicago, IL US
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20100120508 | Wagering game having award group selection feature - A method of conducting a wagering game comprises receiving a wager from a player, and displaying a plurality of selectable elements arranged in an array, each of the selectable elements associated with a respective outcome. The method further comprises receiving a plurality of selections of the selectable elements, and after receiving the plurality of selections, revealing the outcomes associated with the selected elements. For each outcome which comprises an award, the award is provided to the player. For each outcome which comprises an expander element, outcomes associated with all selectable elements in a direction of expansion associated with the expander element are revealed, and if any such revealed outcomes comprise an award, the award is provided to the player. | 05-13-2010 |
20100234093 | Wagering Game With Enhanced Player-Selection Bonus Feature - A gaming system for conducting a wagering game includes a wager input device for receiving a wager from a player to play a wagering game. The system includes a display for displaying an array of selectable elements. Each of the selectable elements is associated with an award. The system also includes a player input device for receiving selections from the array of selectable elements. Also included in the gaming system is a feature for returning to the array of selectable elements. The feature includes at least one game-return outcome and at least one game-terminating outcome awarding a first award for the selections. A multiplier changes each time a game-return outcome is achieved. | 09-16-2010 |
20110045892 | Wagering Game With Game-Play Enhancements Having Known Expected Values - A gaming system and method for conducting a wagering game includes a powerup feature. A wager input receives a wager from a player to play a single play of a wagering game. At least one display displays a plurality of reels with symbols. A controller is coupled to the wager input and the at least one display. The controller is operative randomly generate an outcome of the wagering game from a plurality of wagering game outcomes. The controller displays the randomly generated wagering game outcome on the plurality of reels. The plurality of outcomes includes the award of a powerup to a player. The powerup allows the player to activate a game enhancement feature on a future play of the wagering game. The plurality of wagering game outcomes can also include a credit award. A player may select the credit award or an offered powerup. | 02-24-2011 |
20130165215 | MULTI-PLAYER, MULTI-TOUCH TABLE FOR USE IN WAGERING GAME SYSTEMS - A multi-player gaming system sensing multiple simultaneous contacts on a surface of a gaming table, differentiating contacts by different players. Privacy controls selectively display private information visible to only one of the players on or near the display surface of the gaming table. The gaming system also detects physical objects placed on the surface of the gaming table, causing wagering game functions or peripheral functions to be performed as a result of the placement of the object on the display surface. | 06-27-2013 |
20140051500 | SYSTEMS, METHODS AND DEVICES FOR CONFIGURING WAGERING GAME SYSTEMS AND DEVICES - Gaming devices, gaming systems, methods of configuring gaming devices, and computer programs for configuring gaming devices are featured. A gaming system for playing a wagering game is disclosed which includes a processor(s), an input device(s), a gaming device(s), and a memory device(s) storing instructions that, when executed by at least one of the processors, cause the gaming system to: receive, via at least one of the input devices, a desired value for a player-performance variable and/or a game-configuration variable for at least one of the gaming devices; based on the desired value, output a recommended value for a configuration parameter for the gaming device(s); and, responsive to a confirmation input received via at least one of the input devices, configure the gaming device(s) in accordance with at least the recommended value for the first configuration parameter. | 02-20-2014 |
Joe Palermo, Atlanta, GA US
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20110180096 | Curling Iron with Rotationally Adjustable Handle - A curling iron has a heatable barrel defining a lengthwise axis of the curling iron, a handle assembly having a grip, and a rotation mechanism coupled to a proximal end of the barrel and part of the handle assembly. The rotation mechanism permits rotation of at least part of the handle assembly relative to the barrel about the lengthwise axis of the curling iron between two or more different rotational orientations. | 07-28-2011 |
Joseph Palermo, Brooklyn, NY US
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20090113316 | SYSTEM & METHOD FOR TELEPHONE CONFERENCE BASED COMMUNICATION, ENTERTAINMENT AND ADVERTISING PLATFORM WITH ACCOUNTING FUNCTIONALITY - This invention enables people from the at-home viewing or listening audience of any television or radio broadcast to talk with each other to discuss the program's content on the telephone at any time before, during or after a show. In addition to discussion forums based on broadcast and print media content, the system provides premium priced telephone access to people with specific expertise, e.g., sports stars, politicians and a host of other specialists. Income is earned on a per-minute or flat-rate basis and billed to the caller primarily via credit card or their phone bill. Revenue can be derived from the sale of advertisement, e.g., mentions of the sponsor over the telephone during the initial greeting and within conferences, as well as from the licensing of the service to media networks as a value added service. | 04-30-2009 |
Joseph Palermo, Atlanta, GA US
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20120266483 | Blow Dryer and Controls for Same - A hand-held hair dryer has a body with an air intake and an outlet nozzle. A heating element is positioned within the body between the air intake and the outlet nozzle. A handle extends from the body and defines a hand grip. A temperature controller is located on a surface of the body and configured to control the temperature of the heating element. The temperature controller can lie essentially flush with or below a level of the surface of the body around the temperature controller. A motor control switch can be provided on the handle to operate a motor for directing air from the intake to the heating element and then to the outlet nozzle. | 10-25-2012 |
Joseph Palermo, Hillsdale, NY US
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20130026812 | SKATEBOARD WHEEL MODIFICATION APPARATUS - The present invention concerns a method and apparatus for the securing a secondary outer wheel surface to a primary skateboard wheel so as to change the performance characteristics of said skateboard. The apparatus is further directed to allowing a user to remove or secure said second wheel without the use of customized tools or devices. The present invention is also directed to securing a secondary wheel surface in a manner that prevents the primary wheel from impeding the motions of the skateboard. Through the use of the present invention, a user can customize the performance characteristics of the skateboard without the necessity of replacing wheels | 01-31-2013 |
20130075488 | INSECT REPELLING AND AREA COOLING APPARATUS - The present invention concerns an apparatus for generating a variable or rotating air disturbance with the use of a plurality of filaments controlled by actuators. The filaments are configured to create a movable air disruption that does not require extensive infrastructure to operate and is sufficiently small as to be portable by an individual. The present invention incorporates computer controlled actuators and nozzles to generate programmable air disturbance patterns. | 03-28-2013 |
20140035352 | QUICK RELEASE SKATEBOARD WHEEL - The apparatus and system described is directed to securing a wheel to an axel without the use of separate tools or devices. The present invention allows for securing the wheel to the axel through the use of a specialized locking mechanism and wheel bearing. When mated, these two elements allow for a wheel that does not require user access to a central hub in order to replace the wheel. Thus, the apparatus and device provide for wheel geometries that take advantage of lack of a hub. For example, the present invention allows for wheel designs that enable a wider range of performance characteristics than offered by prior art devices. | 02-06-2014 |
Joseph Palermo, Boynton, FL US
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20140064867 | DOOR LOCK INSTALLATION KIT - A door lock installation kit for use with a first standard door width and a second standard door width, each door having a side face and a front face includes a side hole guide including a side hole aperture arranged to abut the side face of the door, a guide housing movably coupled to the side hole guide, and a back housing movably coupled to the side hole guide and arranged such that the back housing and the guide housing are movable to clamp the door and position the guide housing to abut the front face of the door. A front hole guide includes a front hole guide aperture and is movably coupled to the guide housing and movable to one of a first position corresponding to a first door backset and a second position corresponding to a second door backset. | 03-06-2014 |
Joseph Palermo, Boynton Beach, FL US
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20140374519 | Blending and Dispensing Appliance - A blending and dispensing appliance is provided which includes a blending container, a housing having a recess for supporting the blending container, an ice-shaving unit, and an agitator to agitate shaved ice and other beverage ingredients in the blending container. A conduit is disposed on an outer sidewall of the blending container and fluidly connected to the blending container. An auger is disposed in the conduit and is rotated within the conduit when a dispensing arm is depressed. The rotating auger extrudes blended contents through the conduit from the blending container to a dispensing spout. A motorized base containing both an agitator and an auger motor selectively provide rotary power to the agitator and auger, respectively. A control system is provided for controlling the operation of the ice-shaving motor, the agitator, and the agitator so that the contents placed into the beverage container are blended to a desired consistency. | 12-25-2014 |
20160101533 | Food Processor with Spiralizer Feature - A food processor for cutting a food ingredient includes: a motorized base for generating a rotational force; a processor bowl removably attached to the motorized base; a spindle within the processor bowl in which the spindle can be rotated by the rotational force from the motorized base; a spiralizer cutter attached to the spindle within the processor bowl, the spiralizer cutter having a blade along a radius of the spiralizer cutter; a lid for the processor bowl, the lid having a center position corresponding to the spindle and a radial position between the center position and an edge of the lid; and a feed tube for positioning at one of the center position and the radial position, wherein the feed tube can be repositioned between the center and radial positions. | 04-14-2016 |
Keith Palermo, Gilbert, AZ US
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20120170468 | POWER MANAGEMENT IN A WIRELESS AD HOC NETWORK - In a wireless ad hoc network ( | 07-05-2012 |
Mark G. Palermo, Cambridge, MA US
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20110206690 | DIMERIC IAP INHIBITORS - The present invention provides compounds of formula M-L-M′ (where M and M′ are each independently a monomeric moiety of Formula (I) and L is a linker). The dimeric compounds have been found to be effective in promoting apoptosis in rapidly dividing cells. | 08-25-2011 |
20110281875 | Inhibitors of IAP - Novel compounds that inhibit the binding of the Smac protein to Inhibitor of Apoptosis Proteins (IAPs) of the formula (I). | 11-17-2011 |
20150126513 | 4-PIPERIDINYL COMPOUNDS FOR USE AS TANKYRASE INHIBITORS - The present invention provides for compounds of formula (I): | 05-07-2015 |
Mark G. Palermo, Rindge, NH US
Patent application number | Description | Published |
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20080242658 | Inhibitors of Iap - Novel compounds that inhibit the binding of the Smac protein to Inhibitor of Apoptosis Proteins (IAPs) of the formula I | 10-02-2008 |
20090069294 | Organic Compounds - The present disclosure relates to XIAP inhibitor compounds of the formula I. | 03-12-2009 |
20110281845 | ORGANIC COMPOUNDS - The present disclosure relates to XIAP inhibitor compounds of the formula I. | 11-17-2011 |
20120207769 | Inhibitors of IAP - Novel compounds that inhibit the binding of the Smac protein to Inhibitor of Apoptosis Proteins (IAPs) of the formula (I). | 08-16-2012 |
20140235620 | 3-PYRIMIDIN-4-YL-OXAZOLIDIN-2-ONES AS INHIBITORS OF MUTANT IDH - The invention is directed to a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein R | 08-21-2014 |
Michael Palermo, Trabuco Canyon, CA US
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20140087345 | SURGICAL TRAINING MODEL FOR LAPAROSCOPIC PROCEDURES - A surgical training model that includes a simulated tissue having a tubular shape that is connected to a tissue holder is provided. A portion of the simulated tissue overhangs the distal end of the tissue holder to simulate a cuff-like entry to the vaginal vault or resected intestine suitable for practicing laparoscopic closure of the vaginal vault, intestine or other organ via suturing or stapling. Two concentric tubular structures are also arranged over the same tissue holder. A second model includes two portions of simulated tissue that are held by two holders such that the simulated tissues are adjacent making the model suitable for practicing different types of anastomosis procedures. A third model includes two holders with a single or double tubular simulated tissue structure connected to and spanning a gap between the holders. The model isolates the step of closing a cylindrical opening for the purpose of repeated practice. | 03-27-2014 |
20140087346 | SURGICAL TRAINING MODEL FOR LAPAROSCOPIC PROCEDURES - A surgical training model that includes a simulated tissue having a tubular shape that is connected to a tissue holder is provided. A portion of the simulated tissue overhangs the distal end of the tissue holder to simulate a cuff-like entry to the vaginal vault or resected intestine suitable for practicing laparoscopic closure of the vaginal vault, intestine or other organ via suturing or stapling. Two concentric tubular structures are also arranged over the same tissue holder. A second model includes two portions of simulated tissue that are held by two holders such that the simulated tissues are adjacent making the model suitable for practicing different types of anastomosis procedures. A third model includes two holders with a single or double tubular simulated tissue structure connected to and spanning a gap between the holders. The model isolates the step of closing a cylindrical opening for the purpose of repeated practice. | 03-27-2014 |
Michael Palermo, Rancho Santa Margarita, CA US
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20120082970 | PORTABLE LAPAROSCOPIC TRAINER - A portable surgical training device is provided. The trainer includes a top cover spaced apart from a base to form a simulated body cavity for locating model organs that are substantially obscured from the field of view of the user. The top cover includes a video display, fixed insertion ports and interchangeable inserts containing simulated tissue layers. The training device has open sides for demonstrating and training lateral surgical techniques including a simulated or live tissue colon attached to a support leg for simulating transanal minimally invasive surgery. A training endoscope with an adjustable focal length for use with the trainer and, in particular, with optical trocars is disclosed. The surgical trainer can be angled and is well suited for training laparoscopic surgery techniques and demonstrating surgical instruments. | 04-05-2012 |
20120241076 | METHOD OF MAKING TUBING HAVE DRAINAGE HOLES - A method for manufacturing a kink-resistant tube having drainage holes is provided. A wire is coated with plastic material and wound around a mandrel forming a plurality of windings. The wound coated wire is heated until the plastic coating material melts and bonds the wire windings to form a wire-reinforced sheath having wire-containing sections and non-wire containing sections. Alternatively, a coated or non-coated wire is wound around a mandrel together with separate polymer filament material and then heated. A filament having an elongated cross-section may be employed with the major axis of the elongated cross-section substantially parallel to the longitudinal axis of the sheath. At least one non-wire containing section is identified by passing light through at least one wall of the wire-reinforced sheath. Image capture and analysis via an optical system and microprocessor automatically identify regions to target a drill for forming holes in the non-wire containing sections. | 09-27-2012 |
20140087347 | SURGICAL TRAINING MODEL FOR LAPAROSCOPIC PROCEDURES - A surgical training device includes a model comprising a simulated tissue portion mounted in selectable tension onto a plurality of posts connected to a base. Each post includes at least one notch configured for retaining the simulated tissue portion. Mounting the simulated tissue portion that is in the form of a sheet in notches of different heights creates an angled installation of simulated tissue upon which surgical techniques such as cutting and suturing can be practiced in a simulated laparoscopic environment. More than one sheet can be mounted and each sheet can be mounted with selectable tension by pulling the sheet more or less as desired onto the posts. One variation includes a simulated tumor disposed between sheets, angled or wobbly posts and textured and imprinted simulated tissue surfaces to provide various levels of dynamism and difficulty for surgical skills training in a laparoscopic environment. | 03-27-2014 |
20140087348 | SURGICAL TRAINING MODEL FOR LAPAROSCOPIC PROCEDURES - A surgical training device is provided. The training device includes a practice model comprising a base with a plurality of eyelets connected to the outer surface of the base. The plurality of eyelets defines at least one predetermined pathway for practicing the passing of at least one needle and suture through the eyelets of the predetermined pathway. Various eyelets are described including angled, flexible, deflectable, interchangeable, retractable, rotatable and ones having apertures of various shapes and sizes. The predetermined pathway is marked with markings on the outer surface of base or with color-coded eyelets. Suture pathways define anatomical pathways as well as differing skill levels. The model provides a platform for practicing hand-to-hand transfer and depth perception among other skills required in laparoscopic procedures. | 03-27-2014 |
20140242564 | PORTABLE LAPAROSCOPIC TRAINER - A portable surgical training device is provided. The trainer includes a top cover spaced apart from a base to form a simulated body cavity for locating model organs that are substantially obscured from the field of view of the user. The top cover includes a video display, fixed insertion ports and interchangeable inserts containing simulated tissue layers. The training device has open sides for demonstrating and training lateral surgical techniques including a simulated or live tissue colon attached to a support leg for simulating transanal minimally invasive surgery. A training endoscope with an adjustable focal length for use with the trainer and, in particular, with optical trocars is disclosed. The surgical trainer can be angled and is well suited for training laparoscopic surgery techniques and demonstrating surgical instruments. | 08-28-2014 |
Michael R. Palermo, Hoffman Estates, IL US
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20080290058 | Railroad car draft gear - A railroad car draft gear including a housing having an open end with a friction clutch assembly arranged in operable combination therewith. An elongated elastomeric spring assembly is disposed within the housing for storing energy during axial compression of the draft gear. A spring seat is arranged within the housing between the spring assembly and an end portion of each friction member forming part of the friction clutch assembly. The spring seat defines a surface, arranged in contacting relation with an end of the spring assembly, and defining at least one incongruity for allowing the elastomer of the spring assembly to combine therewith so as to establish a mechanical bond between the spring assembly and the spring seat. | 11-27-2008 |
Phil Palermo, Marietta, GA US
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20090133366 | MULTI-CHAMBER CONTAINER AND CAP THEREFOR - A dispenser comprises a housing that has a removable tamper proof protective cap and tamper proof ring and is threaded to a container. The container, which is the main package, holds the supplemental component. The housing holds the first component into a plunger type chamber in a fully retracted position and is sealed from the supplemental component. The chamber has a delivery end that is closed before use. When pushed all the way in, the chamber's delivery end becomes open and delivers the first component into the main package. | 05-28-2009 |
20110192735 | Multi-Chamber Container and Cap Therefor - A dispenser comprises a housing that has a removable tamper proof protective cap and tamper proof ring and is threaded to a container. The container, which is the main package, holds the supplemental component. The housing holds the first component into a plunger type chamber in a fully retracted position and is sealed from the supplemental component. The chamber has a delivery end that is closed before use. When pushed all the way in, the chamber's delivery end becomes open and delivers the first component into the main package. | 08-11-2011 |
Philip D. Palermo, Marietta, GA US
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20090055988 | Eyewear With Enhanced Fit - Eyewear having an enhanced fit which may be used for safety, sports, and the like. The eyewear may provide features which permit enhanced airflow and an enhanced fit to a user's face. Such features may include greater adjustability to provide greater comfort. Eyewear including an RFID tag which is activated to send or receive transmissions when the eyewear is unfolded and/or positioned in a position to be worn by a user. | 03-05-2009 |
20090077722 | Eyewear With Enhanced Air Flow And/Or Absorption Features - Eyewear having an enhanced air flow and/or absorption features which may be used for safety, sports, and the like. The eyewear may desirably provides features in design and/or function of the structure to enhance air flow and reduce moisture. Additional elements such as removable pads and/or cartridges may be used with the eyewear to enhanced airflow and reduce moisture adjacent a user's eyes and face as well. | 03-26-2009 |
20100110365 | Eyewear With Enhanced Fit - Eyewear having an enhanced fit which may be used for safety, sports, and the like. The eyewear may provide features which permit enhanced airflow and an enhanced fit to a user's face. Such features may include greater adjustability to provide greater comfort. Eyewear including an RFID tag which is activated to send or receive transmissions when the eyewear is unfolded and/or positioned in a position to be worn by a user. | 05-06-2010 |
20100224199 | Respirator - A respirator adapted to facilitate ease of donning and comfort during use comprising one or more of an adjustable or elastic strap that facilitates ease of donning and comfort during wear; and/or fasteners that are easy to use and that facilitate ease of donning and comfort during wear; and/or respirator shapes that facilitate the wearing of eyeglasses with said respirator; and/or bellows-type, pneumatic, or other such components, associated with said respirator, that are adapted to promote adjustability of the fit of the respirator. | 09-09-2010 |
20140237749 | Flexible Mop Head - A wiping tool for arcuate surfaces is disclosed which includes a flexible base and at least one cover attached to the flexible base and a handle attached to the upper surface of the flexible base so that a lower arcuate surface of the flexible base may be aligned with an arcuate surface. | 08-28-2014 |
Philip D. Palermo, Celina, OH US
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20120102647 | HOSPITAL BED - A bed having a frame and a deck is disclosed. The deck has at least a horizontal position and a chair position. The deck has an adjustable-length foot section. | 05-03-2012 |
Raymond Palermo, Marietta, GA US
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20150114238 | VERSATILE COOKER - A versatile cooker that includes a crucible or base, a fire bowl with a cooking surface on top of it and, a cover/lid or dome that rests over the cooking surface. An exemplary embodiment of the cooker can be described as a naturally fired outdoor cooker constructed of a light weight, thermally insulated material such as Autoclaved Aerated Concrete (AAC) as the crucible, a stainless steel fire bowl and a dome lid. A grilling surface constructed out of carbon steel and ceramic disks are used as internal heat sinks. | 04-30-2015 |
Robert Palermo, Seattle, WA US
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20090209483 | TREATMENTS FOR FLAVIVIRIDAE VIRUS INFECTION - The present invention provides methods for treating infections, in a host, by viruses belonging to the Flaviviridae family, such as HCV, comprising administering an Ara-C homologue to the host. | 08-20-2009 |
20110033417 | 2,3-SUBSTITUTED INDOLE DERIVATIVES FOR TREATING VIRAL INFECTIONS - The present invention relates to 2,3-Substituted Indole Derivatives, compositions comprising at least one 2,3-Substituted Indole Derivative, and methods of using the 2,3-Substituted Indole Derivatives for treating or preventing a viral infection or a virus-related disorder in a patient. | 02-10-2011 |
20110033422 | TREATMENTS FOR FLAVIVIRIDAE VIRUS INFECTION - The present invention provides methods for treating infections, in a host, by viruses belonging to the Flaviviridae family, such as HCV, comprising administering an Ara-C homologue to the host. | 02-10-2011 |
Ronald F. Palermo, Rochester, NY US
Patent application number | Description | Published |
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20100007052 | METHOD FOR THE AESTHETIC SURFACE TREATMENT OF A MONOLITHIC CONCRETE FLOOR AND PRODUCT OF THE METHOD - This invention relates generally to a method for forming a concrete floor as a monolithic unit, wherein a wet concrete mix is deposited and worked to achieve a generally uniform flatness of concrete and adding to the top layer thereof a decorative aggregate material. Subsequently, the surface of the concrete is worked, allowed to partially cure and then ground and polished to substantially remove surface irregularities and reveal the decorative aggregate. The floor surface may then be coated with a sealant to achieve a terrazzo-like appearance. | 01-14-2010 |
Steven M. Palermo, Rochester, NY US
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20110204907 | METHOD AND SYSTEM FOR LOW-POWER THREE-PHASE DETECTION - A method and a system for three-phase detection of a three-phase electric device are provided. The system includes a testing circuit and a comparison module. The testing circuit generates two reference voltages by using the three phase voltages of the three-phase electric device. The two reference voltages are the first and second phase voltages with reference to the third phase voltage, respectively. Three-phase detection is performed by comparing the two reference voltages for a determined number of times. After testing is completed, the testing circuit is switched off by the comparison module, to save power. | 08-25-2011 |
Thomas Palermo, San Jose, CA US
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20090318955 | VASCULAR CLOSURE DEVICE - The present invention provides a porous structure that works very effectively to seal a puncture site with optimum porosity, absorbent capacity and perfect anatomical fit. The plug density and other fiber properties/geometry (total denier; number of filaments; etc) have provided an efficient structure that allows instantaneous absorption of blood during deployment. The final size of the plug with absorbed fluids provides an anatomical fit and seals the puncture site within few minutes after deployment. | 12-24-2009 |
20100125276 | METHOD AND SYSTEM FOR REVERSIBLY CONTROLLED DRILLING OF LUMINAL OCCLUSIONS - A luminal drilling system includes a drilling device and a control unit. The drilling device includes an elongate member having a drive shaft with a drill tip. The control unit includes a motor connectable to the drive shaft and control circuitry which rotationally oscillates the drive shaft with the direction of rotation automatically reversing whenever the load on the motor and/or drive shaft exceeds a threshold value. | 05-20-2010 |
20140121688 | METHOD AND SYSTEM FOR REVERSIBLY CONTROLLED DRILLING OF LUMINAL OCCLUSIONS - A luminal drilling system includes a drilling device and a control unit. The drilling device includes an elongate member having a drive shaft with a drill tip. The control unit includes a motor connectable to the drive shaft and control circuitry which rotationally oscillates the drive shaft with the direction of rotation automatically reversing whenever the load on the motor and/or drive shaft exceeds a threshold value. | 05-01-2014 |
Thomas J. Palermo, San Jose, CA US
Patent application number | Description | Published |
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20080221615 | LOCATOR AND CLOSURE DEVICE AND METHOD OF USE - The present invention is directed to a method for sealing a puncture in a wall of a lumen of a body comprising the steps of deploying a deployment member of a sealing device through an elastic membrane adjacent the wall of the lumen and the puncture, wherein the sealing device includes a sealing element; positioning the sealing element adjacent the wall of the lumen; retracting the deployment member relative to the sealing element to stretch the membrane away from the wall of the lumen; retracting the deployment member relative to the sealing element to allow the elastic nature of the membrane to force the sealing element against the puncture; and retracting the device from the puncture. | 09-11-2008 |
20100262176 | BALLOON DISSECTION APPARATUS - Apparatus for creating an anatomic space in tissue in a body including an introducer device having a tubular member with a bore extending therethrough. A tunneling shaft assembly is slidably mounted in the bore of the introducer device. The tunneling shaft assembly includes a tunneling shaft having proximal and distal extremities. A blunt tip is secured to the distal extremity of the tunneling shaft. A balloon assembly is provided. The balloon assembly is removably secured to the tunneling shaft. The balloon assembly includes a deflated collapsed balloon. A sheath encloses the balloon and is carried by the tunneling shaft. The sheath has a weakened region extending longitudinally thereof permitting the sheath to be removed to release the balloon. | 10-14-2010 |
20110166584 | CLIP APPLIER AND METHODS OF USE - An apparatus for delivering a closure element into an opening formed in a blood vessel or other body lumen and methods for manufacturing and using same. The apparatus is configured to retain the closure element such that the closure element is disposed substantially within the apparatus. The apparatus also can engage, and position the closure element substantially adjacent to, the blood vessel wall adjacent to the opening. During deployment of the closure element, the apparatus expands the closure element beyond a natural cross-section of the closure element such that the closure element, when deployed, is configured to engage a significant amount of the blood vessel wall and/or tissue. Engaging the blood vessel wall and/or tissue, the closure element is further configured to return to the natural cross-section, thereby drawing the engaged blood vessel wall and/or tissue substantially closed and/or sealed, such that hemostasis within the opening is enhanced. | 07-07-2011 |
20110230897 | CLIP APPLIER AND METHODS OF USE - An apparatus for delivering a closure element can include a splittable carrier tube and a splitter to split the tube. The carrier tube can have an outer surface retaining a closure element in a tubular configuration and can be split into radially-expandable flaps. A closure element can have a shape-memory body having a relaxed configuration with a planar-annular body defining a lumen with tines directed inwardly from the body. The clip can be held in a retaining configuration having a substantially asymmetrically-elongated tubular shape with a trapezoidal longitudinal cross-sectional profile and a proximal end having the tines being longitudinally directed with a first tine being more distally oriented compared to a substantially opposite second tine being more proximal, and retracting to a deploying configuration having a tubular shape with a rectangular longitudinal cross-sectional profile with the first tine being even with the second tine when being delivered. | 09-22-2011 |
20120089179 | LOCATOR AND CLOSURE DEVICE AND METHOD OF USE - The present invention is directed to a device which is capable of both locating a punctured blood vessel wall and sealing the puncture in the vessel and to the method of using the device as well. In one embodiment, the device includes an elongate deployment member having a sealing element releasably disposed within a distal end thereof, said deployment member being coupled to a first actuator configured to retract said deployment member relative to said sealing element, and an elongated indicator member having a proximal end and a distal end, said indicator member extending through a lumen in said deployment member such that the distal end of said indicator member extends distally of the distal end of the deployment member, and said indicator member being coupled to a second actuator configured to retract said indicator member relative to said deployment member. | 04-12-2012 |
20120101520 | VASCULAR PLUG HAVING COMPOSITE CONSTRUCTION - This invention relates to apparatus and methods used to seal a vascular puncture site, particularly sites of punctures that are the result of catheterization or other interventional procedures. The sealing device includes a sealing member and a tether. The sealing member occupies a space in an incision, puncture, or other wound and sealing the space that it occupies, to prevent further blood flow. The tether is attached to the sealing member, and provides the user with the ability to withdraw the sealing member if necessary. The sealing device further includes a restraining member associated with the sealing member. The restraining member provides the ability to more securely restrain the sealing member to prevent it from migrating from the deployment location within a tissue tract. The restraining member also provides an additional capability of manipulating the sealing member after deployment. | 04-26-2012 |
20130190778 | CLIP APPLIER AND METHODS OF USE - An apparatus for delivering a closure element can include a splittable carrier tube and a splitter to split the tube. The carrier tube can have an outer surface retaining a closure element in a tubular configuration and can be split into radially-expandable flaps. A closure element can have a shape-memory body having a relaxed configuration with a planar-annular body defining a lumen with tines directed inwardly from the body. The clip can be held in a retaining configuration having a substantially asymmetrically-elongated tubular shape with a trapezoidal longitudinal cross-sectional profile and a proximal end having the tines being longitudinally directed with a first tine being more distally oriented compared to a substantially opposite second tine being more proximal, and retracting to a deploying configuration having a tubular shape with a rectangular longitudinal cross-sectional profile with the first tine being even with the second tine when being delivered. | 07-25-2013 |
20150080946 | LOCATOR AND CLOSURE DEVICE AND METHOD OF USE - The present invention is directed to a method for sealing a puncture in a wall of a lumen of a body comprising the steps of deploying a deployment member of a sealing device through an elastic membrane adjacent the wall of the lumen and the puncture, wherein the sealing device includes a sealing element; positioning the sealing element adjacent the wall of the lumen; retracting the deployment member relative to the sealing element to stretch the membrane away from the wall of the lumen; retracting the deployment member relative to the sealing element to allow the elastic nature of the membrane to force the sealing element against the puncture; and retracting the device from the puncture. | 03-19-2015 |
Timothy Palermo, Mission Viejo, CA US
Patent application number | Description | Published |
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20140298897 | HIGH SPEED NANO WEAR TESTING APPARATUS - The present invention is a nano wear testing apparatus, which preferably includes a linear motor, nano module assembly, piezoelectric member, load cell, tip mounting shaft, stage, and speaker coil. The linear motor preferably repositions the nano module assembly in close contact to the surface of a test sample, which is generally attached to the stage. The piezoelectric member moves the load cell and tip mounting shaft near the surface of the sample, and the load cell detects a contact load defined in the software application. The piezoelectric member continues to increase the load until the predetermined load for the test is reached. Once reached, the speaker coils shifts the stage at a frequency and stroke length set in the software application. During the test, the load cell and piezoelectric table continuously adjusts to keep a constant load during the test. Once the test is finished, the speaker coil stops and the load is then removed. Generally, load and depth data is recorded during the test. | 10-09-2014 |
Vincent Palermo, Westford, MA US
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20100045269 | METHODS AND APPARATUS TO DETECT LOCATION AND ORIENTATION IN AN INDUCTIVE SYSTEM - A base station (e.g., a central device including a transducer assembly of one or more orthogonal transducers) transmits a magnetic field at a known power level and direction. The magnetic field signal includes data information transmitted from the base station to a movable remote station. The remote station includes a transducer assembly of one or multiple transducer coils to receive the magnetic field generated by the base station. Location and orientation of the remote station (with respect to the base station) are determined based on the magnitude, amplitude, and/or phase of magnetic field signals received on each of the remote station's transducers. The remote station may transmit the location and orientation information (e.g., raw measured data or converted data) to the base station using the same coils as used by the remote station to receive the magnetic field generated by the base station. | 02-25-2010 |