Hazeki
Kaoru Hazeki, Hiroshima JP
Patent application number | Description | Published |
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20090317833 | Screening Method - The present invention provides a method of screening for a drug for the prophylaxis or treatment of at least one disease selected from the group consisting of cardiac disease, autoimmune disease, inflammatory disease, central nervous system disease, infectious disease, sepsis, severe sepsis and septic shock, which includes selecting a substance that binds to an intracellular region of TLR4, and inhibits signal transduction from said molecule, and a kit for this method, which contains (1) a cell that expresses wild-type TLR4 and (2) a cell that expresses a mutant TLR4, and which can detect a signal from TLR4 with expression of a reporter gene as an index. | 12-24-2009 |
Osamu Hazeki, Hiroshima JP
Patent application number | Description | Published |
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20090317833 | Screening Method - The present invention provides a method of screening for a drug for the prophylaxis or treatment of at least one disease selected from the group consisting of cardiac disease, autoimmune disease, inflammatory disease, central nervous system disease, infectious disease, sepsis, severe sepsis and septic shock, which includes selecting a substance that binds to an intracellular region of TLR4, and inhibits signal transduction from said molecule, and a kit for this method, which contains (1) a cell that expresses wild-type TLR4 and (2) a cell that expresses a mutant TLR4, and which can detect a signal from TLR4 with expression of a reporter gene as an index. | 12-24-2009 |
Shingo Hazeki, Kanagawa JP
Patent application number | Description | Published |
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20150027857 | BELT-DEVIATION SUPPRESSION STRUCTURE, TRANSFER DEVICE, AND IMAGE FORMING APPARATUS - A belt-deviation suppression structure includes a contact member, receivers, and multiple link members. The contact member is in contact with a rotatable belt and extends longitudinally in an intersecting direction that intersects a moving direction of the belt. The receivers are provided at opposite sides of the contact member in the intersecting direction and receive a pressing force from the belt as the belt moves in the intersecting direction. The link members are arranged in the intersecting direction. Each link member has a first end that is connected to a base in a rotatable manner about an axis extending in the moving direction and has a second end that is connected to the contact member in a rotatable manner about an axis extending in the moving direction. | 01-29-2015 |
Takahiro Hazeki, Wako-Shi JP
Patent application number | Description | Published |
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20100326776 | GARNISH PLATE MOUNTING STRUCTURE - A garnish plate mounting structure allows a garnish plate to be installed to a caliper body without the need for any special machining of the caliper body, thus achieving improved general versatility. An engaging member is disposed along an external surface of a second pad opposing an arm portion of the caliper body. The engaging member has engaging portions which engage the second pad. The engaging member is held between the arm portion and the second pad. The garnish plate is disposed at an external surface of the caliper body and connected to the engaging member through the intermediary of connecting portions provided extendedly on both sides of the engaging portion. | 12-30-2010 |
20130256068 | DISC BRAKE DEVICE - A disc brake device for applying brake to wheels by pressing a disc rotor between pads, the disc brake device includes: pads disposed at a position to press the disc rotor; a first piston which can press one pad; a cylinder which slidably supports the first piston; and a body frame which can press the other pad, the body frame having: a pad connection portion which connects to the other pad in a push-pull manner; and a sliding portion which is slidably supported by the cylinder. The disc brake device includes a caliper bracket which supports the pads not to limit a movement in the axial direction, but to limit a movement in any direction other than the axial direction on disc-rotor-rotating-in and disc-rotor-rotating-out sides of the disc brake device, the caliper bracket being provided integrally with the cylinder and separated from the pad connection portion. | 10-03-2013 |