Patent application number | Description | Published |
20090193370 | Bondwire Design - A system and method of designing the physical shape of and determining the electromagnetic characteristics of a bondwire in an electrical circuit, comprising the steps of enabling a user to define the position of the bondwire in the electrical circuit layout, defining the position and loop shape of the bondwire in a 3D representation of the electrical circuit, segmenting the bondwire into discrete segments, determining the electromagnetic characteristics of each of the bondwire segments thereby to determine the overall electromagnetic characteristics of the bondwire. | 07-30-2009 |
20100088657 | EXPERT SYSTEM-BASED INTEGRATED INDUCTOR SYNTHESIS AND OPTIMIZATION - Apparatus and method for designing an electrical component in an integrated circuit, the apparatus comprising a processor, a user interface, and memory for storing data, the interface enabling a user to input a desired characteristic of the electrical component, such as inductance L or quality factor Q at an operating frequency f for an integrated spiral inductor, and the processor being adapted to determine sufficient optimal characteristics of the electrical component to define the electrical component for fabrication in the integrated circuit, the processor being adapted to combine the user desired characteristic with other preset characteristics of the electrical component or the integrated circuit, to define a first model of the electrical component, to simulate the model having the combined characteristics to determine performance, and to draw on a rule-set of expert knowledge relating to the general dependency of at least one design criterion, such as a physical, geometrical or performance characteristic, with another design criterion in order to enable modification of the model, thereby iteratively to determine a design solution for the electrical component through one or more simulations and modifications using the rule-set. | 04-08-2010 |
20110313738 | SYSTEM AND METHOD FOR CIRCUIT ANALYSIS - Systems and methods related to fast simulation of power supply networks and identification of a set of extrema (e.g., maxima or minima) waveforms associated with the power supply networks. In accordance with an embodiment, a method is provided for estimating the worst case voltage drop on the power delivery network of a circuit, comprising selecting a model of a power delivery network of a circuit, simulating the circuit over a predefined number of vectors, collecting dynamic voltage waveforms at each of a plurality of points on the power delivery network, calculating a dynamic worst case voltage waveform at each of the plurality of points, and reporting the dynamic worst case voltage waveform along with an associated confidence interval. | 12-22-2011 |
20120016652 | SYSTEM AND METHOD FOR FAST POWER GRID AND SUBSTRATE NOISE SIMULATION - Systems and methods related to fast simulation of power supply networks and identification of a set of extrema (e.g., maxima or minima) waveforms associated with the power supply networks. In accordance with an embodiment, a method is provided for simulating an electrical circuit, comprising preselecting an input vector file, initializing a supply voltage to a fixed value, performing event driven simulation using the input vector file, so as to extract time-varying power supply current waveforms at a plurality of power grid points. The method also comprises simulating a power grid using a linear network simulator or other SPICE type simulation tool, so as to derive time-varying voltage waveforms from the current waveforms for each point on the power grid. The method further comprises comparing current and/or voltage waveforms with a previous simulation; and repeating the above steps from event driven simulation onwards, using a function of voltage waveforms from previous simulations, until the values of current and/or voltage waveforms converge within a pre-specified tolerance, or an iteration limit has been reached. | 01-19-2012 |
20120123917 | SYSTEM AND METHOD FOR VARIABLE TIME-BASED LICENSING - A system and method for variable time-based licensing is provided, which includes a chips cache which stores activated chips and a chips pool which stores inactive chips. In this context “chips” can be considered a currency which can be traded to use software tools for a period of time associated with each chip. The system further includes a chips accounting manager, operable to receive license requests for software tools and to determine whether to grant the license request; and a license manager which tracks active chips and manages activated chip check-in and checkout. When the chips accounting manager receives a license request for a software tool the chips accounting manager determines whether the chips cache includes sufficient chips to access the software tool. If there are insufficient chips, the chips accounting manager checks whether inactive chips in the chip pool can be activated and added to the chips cache. If there are sufficient chips, the chips accounting manager notifies the license manager to check out the sufficient chips from the chips cache and grant access to the software tool. | 05-17-2012 |
20130159128 | SYSTEM AND METHOD FOR PROVIDING SECURITY IN VARIABLE TIME-BASED LICENSING SYSTEMS - A system and method for a software licensing system for use in e.g., a variable time-based licensing, is provided. Such a system includes a secure device, including a first computer readable medium, configured to connect to a computer, including a second computer readable medium and microprocessor. The secure device can further include a chips pool which stores inactive chips, and a chips accounting manager, operable to receive license requests for software tools and to determine whether to grant the license request. In this context “chips” can be considered a currency which can be traded to use software tools for a period of time associated with each chip. The system further includes a license server, executing on the computer. The license server can include a license manager which tracks active chips and manages activated chip check-in and checkout, and a chips cache which stores activated chips. | 06-20-2013 |
20140250417 | EXPERT SYSTEM-BASED INTEGRATED INDUCTOR SYNTHESIS AND OPTIMIZATION - Apparatus and method for designing an electrical component including a processor and a user interface, enabling a user to input a desired characteristic of the electrical component, such as inductance or quality factor at an operating frequency for an integrated spiral inductor. The processor is configured to determine sufficiently optimal characteristics of the electrical component, combining the user desired characteristic with other preset characteristics of the electrical component, to define a first model of the electrical component, to simulate the model having the combined characteristics to determine performance, and to draw on a rule-set of expert knowledge relating to the general dependency of at least one design criterion, such as a physical, geometrical or performance characteristic, with another design criterion in order to enable modification of the model, thereby iteratively to determine a design solution for the electrical component through one or more simulations and modifications using the rule-set. | 09-04-2014 |
20150100934 | INTEGRATED TRANSFORMER SYNTHESIS AND OPTIMIZATION - A method for designing a transformer in an integrated circuit includes receiving one or more desired characteristics of the transformer from user input and iteratively determining a design solution for the transformer through one or more simulations and modifications using a rule-set. The method combines the one or more desired characteristics with other preset characteristics of the transformer or the integrated circuit. A first model of the transformer is defined with typical load impedances and simulated having the combined characteristics to determine performance. Results of the simulation are processed to calculate performance with the load impedances specified by the user. The results are further processed to obtain a mathematical model that includes tuning capacitors. The first and subsequent models are modified by drawing on a rule-set of expert knowledge relating to general dependency of at least one design criterion, such as a physical, geometrical or performance characteristic, with another design criterion. | 04-09-2015 |
20150261900 | CIRCUIT ELEMENT SYNTHESIS AND OPTIMIZATION - A method for designing a circuit element of an integrated circuit (IC) includes receiving one or more desired characteristics of the circuit element from user input and iteratively determining a design solution through one or more simulations and modifications using a rule-set. The one or more desired characteristics are combined with other preset characteristics of the circuit element or the IC. A first model of the circuit element is defined and simulated to calculate performance. The first and subsequent models are modified by drawing on a rule-set of expert knowledge relating to general dependency of at least one design criterion, such as a physical, geometrical or performance characteristic, with another design criterion. | 09-17-2015 |
Patent application number | Description | Published |
20140302144 | MULTI-LAYERED INJECTABLE SELF-ASSEMBLING PEPTIDE SCAFFOLD HYDROGELS FOR LONG-TERM SUSTAINED RELEASE OF HUMAN ANTIBODIES - The invention relates to a pharmaceutical formulation for sustained delivery of a therapeutic agent, preferably a protein, polypeptide, an antibody or an antibody fragment, comprising one or more gel forming peptides wherein the formulation exhibits sustained delivery for at least two weeks, three weeks, four weeks, five weeks, six weeks, seven weeks, eight weeks, nine weeks, ten weeks, eleven weeks, twelve weeks or more. In one embodiment, the invention relates to a formulation comprising self-assembling peptides that undergo sol-gel transition in the presence of an electrolyte solution such as biological fluids and salts. The formulation can provide sustained release of antibody and antibody fragments, in particular, IgG. Antibody diffusivities can be decreased with increasing hydrogel nanofiber density, providing a means to control the release kinetics. | 10-09-2014 |
20150147384 | Sustained Delivery of Molecules Using Peptide Surfactants and Uses Thereof - The present invention is directed to a drug delivery composition comprising a self-assembled nanostructure and biologically active molecule, wherein the nanostructure comprises surfactant peptides, and wherein the biologically active molecule is encapsulated in the nanostructure. The invention also encompasses methods of administering a biologically active molecule to a subject comprising administering the drug delivery composition and methods for the preparation of said composition. | 05-28-2015 |
Patent application number | Description | Published |
20080301485 | REGISTER WITH PROCESS, SUPPLY VOLTAGE AND TEMPERATURE VARIATION INDEPENDENT PROPAGATION DELAY PATH - The digital data register has a plurality of parallel matched data paths, each data path having a data input for receiving a digital data input signal (CA/CNTRL), an output driver with a data output providing a digital data output signal (Q_CA/CNTRL) for application to an associated memory module and a flip-flop (FF1) arranged between the data input and the data output. The data register further comprises a clock input for receiving a clock input signal (CLK), a clock output for providing an output clock signal (Q_CLKn, Q_NCLKn) to the memory modules, a phase locked loop (PLL) with a clock input (REF), a feedback input (FB), a feedback output providing a feedback output signal (Q_NFB) and a clock output providing a clock output signal (Q_CLK, QNCLK). In addition a flip-flop (FF1 DELAY) and output driver replica are matched with the flip-flop and output driver of the data paths. the flip-flops (FF1) of the data paths and the flip-flop (FF1 DELAY) of the replica are clocked by the feedback signal applied to the feedback input (FB) of the phase locked loop (PLL). The phase locked loop (PLL) includes a phase aligner with a phase interpolator. The phase interpolator has an output that provides the output clock signal (Q_CLKn, Q_NCLKn) to the memory modules through a flip-flop (FF1 DELAY) and output driver matched with the flip-flop and output driver of the data paths. A phase frequency detector (PFD) has a first input (REF) coupled to the output of the output driver replica and a second input (SYS) coupled to the clock output. The phase interpolator is controlled by the output of the phase frequency detector (PFD). The proposed data register satisfies the three requirements of: (i) setup and hold timing on the pre-register side, (ii) clock centering on the post-register side, and (iii) constant propagation delay time (tpd) over PVT variations from the clock input to the data output. | 12-04-2008 |
20100299486 | Electronic Devices and Methods for Storing Data in a Memory - An electronic device containing a memory having a plurality of memory modules. Each memory module includes a plurality of memory devices. The electronic device also contains a data bus having a number of lines for transferring data from and to the memory devices. The data bus is configured to have at least two sub-sets of lines coupled to different memory modules. A method including reading a data word from memory devices of different memory modules through a data bus using different subsets of lines of the data bus for each memory module. | 11-25-2010 |
20150155867 | ADAPTIVE BUS TERMINATION APPARATUS AND METHODS - Termination impedance of a digital signal bus is adaptively selected as a function of a present or anticipated state of the bus. A variable termination resistor is arranged in series between a termination switch and a common voltage node at the termination end of each bus conductor. Information regarding the current or anticipated bus state is received from an external device such as a bus controller or may be derived by sensing activity on the bus. For example, clock frequency detection logic coupled to clock lines of the bus senses the current operational speed of the bus. A highest-value termination resistance predetermined to be consistent with reliable bus operation under conditions of the current or anticipated bus state is selected for each bus conductor. A bus conductor termination may be taken to a high impedance state by opening the associated termination switch. Decreased average bus power consumption may result. | 06-04-2015 |
Patent application number | Description | Published |
20090317819 | PHOSPHOLIPID OXIDATION AND Lp-PLA2 AS PREDICTORS OF CORONARY ARTERY DISEASE - Provided herein are compositions and methods for identifying individuals at risk for developing coronary artery disease (CAD). | 12-24-2009 |
20110097272 | Method and Materials for Use in Diagnosing Viral Myocarditis - The invention consists of assay methods, assay kits and antibodies for detecting the polypeptide fragments of dystrophin protein cleavage by enteroviral protease | 04-28-2011 |
20110229919 | COMBINATION OF SPLA2 ACTIVITY AND OXPL/APOB CARDIOVASCULAR RISK FACTORS FOR THE DIAGNOSIS/PROGNOSIS OF A CARDIOVASCULAR DISEASE/EVENT. - A method of identifying a subject having or at risk of having or developing a cardiovascular disease and/or a cardiovascular event, includes:
| 09-22-2011 |
20120035074 | METHODS TO DETERMINE ATHEROSCLEROSIS REGRESSION, PLAQUE STABILIZTION AND CARDIOVASCULAR RISK - Provided herein are compositions and methods for examining the progression, regression or risk of individuals at risk for developing coronary artery disease (CAD). | 02-09-2012 |
20120149596 | METHODS FOR ASSESSING ATHEROGENESIS BY DETERMINING OXIDIZED PHOSPHOLIPID TO APOLIPOPROTEIN B RATIOS - The present invention relates to the analysis of oxidized phospholipids (OxPL) on apolipoprotein B-100 in patients at high risk or with documented coronary artery disease (CAD) or acute coronary syndromes (ACS) such as unstable angina and acute myocardial infarction or suspected of being at risk for ACS. Such methods are useful for diagnostic purposes and for monitoring the effects of dietary interventions or with drugs such as statins. More particularly, the present invention relates to methods for determining OxPL/apoB ratios as indices of atherosclerosis regression and plaque stability. | 06-14-2012 |
20120171705 | COMBINATION OF SPLA2 ACTIVITY AND OXPL/APOB CARDIOVASCULAR RISK FACTORS FOR THE DIAGNOSIS/PROGNOSIS OF A CARDIOVASCULAR DISEASE/EVENT - The use of a combination of sPLA2 activity and OxPL/apoB cardiovascular risk factors for the diagnosis/prognosis of a cardiovascular disease/event or for the monitoring of a cardiovascular disease. | 07-05-2012 |
20120264146 | COMBINATION OF SPLA2 ACTIVITY AND LP(A) CARDIOVASCULAR RISK FACTORS FOR THE DIAGNOSIS/PROGNOSIS OF A CARDIOVASCULAR DISEASE/EVENT - The present invention related to a method of identifying a subject having or at risk of having or developing a cardiovascular disease and/or a cardiovascular event, comprising: -measuring, in a sample obtained from said subject, at least two cardiovascular risk factors: a) s PLA2 activity and b) Lipoprotein(a), -combining said measurements, the combined value of s PLA2 activity and Lp(a) being indicative of having or a risk of having or developing a cardiovascular disease and/or cardiovascular event. | 10-18-2012 |
20140309124 | METHODS FOR ASSESSING ATHEROGENESIS BY DETERMINING OXIDIZED PHOSPHOLIPID TO APOLIPOPROTEIN B RATIOS - The present invention provides methods to analyze oxidized phospholipids (OxPL) on apolipoprotein B-100 in patients at high risk or with documented coronary artery disease (CAD) or acute coronary syndromes (ACS) such as unstable angina and acute myocardial infarction or suspected of being at risk for ACS. Such methods are useful for diagnostic purposes and for monitoring the effects of dietary interventions or with drugs such as statins. More particularly, the disclosure provides methods for determining OxPL/apoB ratios as indices of atherosclerosis regression and plaque stability. | 10-16-2014 |
20150056209 | PEPTIDE MIMOTOPES TO OXIDATION SPECIFIC EPITOPES - Provided herein are peptide mimotopes that are useful for generating antibodies and in the preparation of vaccines and diagnostics for treating and diagnosing coronary artery disease. | 02-26-2015 |
20150132771 | COMBINATION OF SPLA2 ACTIVITY AND LP(A) CARDIOVASCULAR RISK FACTORS FOR THE DIAGNOSIS/PROGNOSIS OF A CARDIOVASCULAR DISEASE/EVENT - The present invention related to a method of identifying a subject having or at risk of having or developing a cardiovascular disease and/or a cardiovascular event, comprising: —measuring, in a sample obtained from said subject, at least two cardiovascular risk factors: a) s PLA2 activity and b) Lipoprotein(a), —combining said measurements, the combined value of s PLA2 activity and Lp(a) being indicative of having or a risk of having or developing a cardiovascular disease and/or cardiovascular event. | 05-14-2015 |
20150185239 | OXIDATIVE BIOMARKERS IN PREDICTING RISK OF STROKE, TRANSIENT ISCHEMIC ATTACK (TIA) AND PERIPHERAL ARTERIAL DISEASE (PAD) - Provided herein are compositions and methods for examining the progression, regression or risk of individuals for having a stroke, transient ischemic attack or peripheral artery disease. | 07-02-2015 |
20150376268 | ANTIBODIES TO OXIDIZED PHOSPHOLIPIDS - The disclosure provides for single chain variable fragments to oxidized phospholipid epitopes and methods of use thereof, including the production of transgenic animal models and the use of the fragments as therapeutic agents for treating CAS. | 12-31-2015 |