Lawrence, MI
Andrea Lawrence, Clarkston, MI US
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20140000627 | PERCUTANEOUS ACCESS DEVICE | 01-02-2014 |
Anthony Lawrence, Royal Oak, MI US
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20160127809 | INTEGRATED WORK DESK SYSTEM AND METHOD FOR ENCOURAGING AND TRACKING STANDING - A work desk system is disclosed which is integrated into a corporate work environment. The work desk system includes a work desk which can be raised and lowered to promote performing various activities such managing email, carrying out a telecon, participating in a webinar, while standing rather than seated. The system is able to determine from the user's calendar when certain events are upcoming that could be performed while standing, and is able to notify the user with a message on the user's computing device of the opportunity to perform the event while standing. The system is able to monitor whether the user is seated or standing, in one implementation using an intelligent caster associated with a chair present at the work desk. The system also logs the accumulated time that the worker spends standing, and shares the information with other subsystems (health applications, health care provider, corporate entity that employs the user, etc.). | 05-05-2016 |
20160128467 | HEIGHT ADJUST SENSING AND CONTROL SYSTEM AND METHOD FOR AN ADJUSTABLE WORK DESK - The present disclosure relates to a furniture height adjustment system. The system has a height adjust system positionable on or adjacent a work surface of a furniture component, wherein the work surface is movable elevationally between lowered and raised positions. The height adjust system has a processor and a height adjust setting control in communication with the processor. The height adjust setting control has user actuatable controls for enabling a user to set and store at least one elevational position for the work surface. The processor monitors movement of the work surface when the user is moving the work surface to a previously stored elevational position and generates a signal when the work surface reaches the stored elevational position. | 05-12-2016 |
Daniel Lawrence, Ann Arbor, MI US
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20080198015 | RFID SYSTEM - An RFID system including a battery powered RFID reader configured to detect an RFID tag. The RFID reader include a mounting surface configured to be affixed relative to an external structure, and is capable of being wirelessly coupled to a receiver for transmitting data to the receiver. | 08-21-2008 |
20080198016 | RFID SYSTEM - An RFID system and network including an RFID reader capable of detecting an RFID tag. The RFID system further includes an intermediate device configured to be wirelessly coupled to the RFID reader. A third device is configured to be coupled to the intermediate device for communicating with the RFID reader via the intermediate device. | 08-21-2008 |
20120156187 | METHODS AND COMPOSITIONS FOR MODULATION OF BLOOD-NEURAL BARRIER - Methods and compositions for modulating blood-neural barrier (BNB) for the treatment of CNS conditions such as edema, and for increased drug delivery efficacy across the BNB. The present invention further relates to improved tPA treatment of ischemic cerebrovascular and related diseases in combination with antagonism of the PDGF signaling pathway. The inventive method and composition is particularly suitable for conjunctive therapy of ischemic stroke using tPA and an anti-PDGF-C antagonist or an anti-PDGFR-α antagonist. | 06-21-2012 |
20140255397 | METHODS AND COMPOSITIONS FOR MODULATION OF BLOOD-NEURAL BARRIER - Methods and compositions for modulating blood-neural barrier (BNB) for the treatment of CNS conditions such as edema, and for increased drug delivery efficacy across the BNB. The present invention further relates to improved tPA treatment of ischemic cerebrovascular and related diseases in combination with antagonism of the PDGF signaling pathway. The inventive method and composition is particularly suitable for conjunctive therapy of ischemic stroke using tPA and an anti-PDGF-C antagonist or an anti-PDGFR-α antagonist. | 09-11-2014 |
Daniel A. Lawrence, Ann Arbor, MI US
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20090011055 | Plasminogen Activator Inhibitor-1 Inhibitors And Methods Of Use Thereof To Modulate Lipid Metabolism - The invention relates to plasminogen activator-1 (PAI-1) inhibitor compounds and uses thereof in the treatment of any disease or condition associated with elevated PAI-1. The invention includes, but is not limited to, the use of such compounds to modulate lipid metabolism and treat conditions associated with elevated PAI-1, cholesterol, or lipid levels. | 01-08-2009 |
20100137194 | Plasminogen Activator Inhibitor-1 Inhibitors and Methods of Use Thereof to Modulate Lipid Metabolism - The invention relates to plasminogen activator-1 (PAI-1) inhibitor compounds and uses thereof in the treatment of any disease or condition associated with elevated PAI-1. The invention includes, but is not limited to, the use of such compounds to modulate lipid metabolism and treat conditions associated with elevated PAI-1, cholesterol, or lipid levels. | 06-03-2010 |
20100286053 | PLASMINOGEN ACTIVATOR INHIBITOR AMELIORATION OF NEWBORN HYPOXIC ISCHEMIC BRAIN INJURY - Plasminogen activators as potential therapeutic targets in neonatal hypoxia ischemia (HI) brain injury. Use of plasminogen activator inhibitor-1 (PAI-1) to ameliorate HI encephalopathy related disease. Use of PAI-1 as preventive treatment of cerebral palsy (CP). | 11-11-2010 |
20140343321 | Plasminogen Activator Inhibitor-1 Inhibitors and Methods of Use Thereof to Modulate Lipid Metabolism - The invention relates to plasminogen activator-1 (PAI-1) inhibitor compounds and uses thereof in the treatment of any disease or condition associated with elevated PAI-1. The invention includes, but is not limited to, the use of such compounds to modulate lipid metabolism and treat conditions associated with elevated PAI-1, cholesterol, or lipid levels. | 11-20-2014 |
20150315178 | PLASMINOGEN ACTIVATOR INHIBITOR-1 INHIBITORS AND METHODS OF USE THEREOF - The invention relates to plasminogen activator-1 (PAI-1) inhibitor compounds and uses thereof in the treatment of any disease or disorder associated with elevated PAI-1. The invention includes, but is not limited to, the use of such compounds to prevent or reduce thrombosis and fibrosis, to promote thrombolysis, and to modulate lipid metabolism and treat diseases or disorders associated with elevated PAI-1, cholesterol, or lipid levels. | 11-05-2015 |
Daniel P. Lawrence, Ann Arbor, MI US
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20150041537 | AUTOMATIC SENSING METHODS AND DEVICES FOR INVENTORY CONTROL - The present disclosure is generally directed to methods of tracking stocked inventory, such as products or other items stocked on a store shelf or other storage space. The disclosure is also directed to devices and systems that may be utilized to carry out such methods. | 02-12-2015 |
20150041616 | AUTOMATIC SENSING METHODS AND DEVICES FOR INVENTORY CONTROL - The present disclosure is generally directed to methods of tracking stocked inventory, such as products or other items stocked on a store shelf or other storage space. The disclosure is also directed to devices and systems that may be utilized to carry out such methods. | 02-12-2015 |
20150048161 | AUTOMATIC SENSING METHODS AND DEVICES FOR INVENTORY CONTROL - The present disclosure is generally directed to methods of tracking stocked inventory, such as products or other items stocked on a store shelf or other storage space. The disclosure is also directed to devices and systems that may be utilized to carry out such methods. | 02-19-2015 |
David A. Lawrence, Clarkston, MI US
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20160076471 | ENGINE CYLINDER BANK-TO-BANK TORQUE IMBALANCE CORRECTION - An engine bank-to-bank airflow balancing technique includes calculating current and offset volumetric efficiencies of the engine and calculating a slope representing (i) a difference between the offset and current volumetric efficiencies and (ii) a difference between offset and current intake camshaft positions. Based on the respective exhaust gas oxygen concentrations, the technique involves calculating a volumetric efficiency correction corresponding to each cylinder bank and based on the slope and the volumetric efficiency corrections, calculating target intake camshaft position shifts. The technique further involves controlling offsets of the intake camshafts based on the target intake camshaft position shifts. After a predetermined number of target intake camshaft position shifts are determined and stored with respect to various combinations of engine speed and a ratio of intake manifold pressure to barometric pressure, final intake camshaft position shifts may be determined and utilized when determining the intake camshaft positions. | 03-17-2016 |
David J. Lawrence, Wayne, MI US
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20140131319 | Method For Welding A Weld-On Element Onto A Counterpart - A method for welding a weld-on element onto a component is proposed, comprising at least the step that, before the welding process, at least one of the parts being connected is wetted with a wetting agent over the full area and uniformly in layer thickness in a welding region. | 05-15-2014 |
Deanna Lawrence, Temperance, MI US
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20140324570 | Network Communication Filtering, Data Collection and Marketing Platform - A computer implemented method for providing social media data to brands comprising pairing a user with a brand in response to the user requesting a connection with the brand. A privacy agreement is made between the user and the brand to facilitate receiving social media data related to the user. A user data package is created that includes at least a portion of the social media data and the user data package includes data based on instructions from the brand. Data is removed from the user data package that is excluded by the privacy agreement to create a filtered data package. The filtered data package is then sent to the brand. Remote social media data is received from a remote social media network in response to the user selecting a link with the remote social media network and the remote social media data is added to the social media data. | 10-30-2014 |
Don Lawrence, Birmingham, MI US
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20080223021 | Ammonia vapor management system and method - A method of managing vapors generated from an ammonia-containing reductant delivery system for an engine, comprising of storing an ammonia-containing fluid in a first storage device; generating ammonia vapors in the first storage device and storing said generated ammonia vapors in a second storage device; and purging said stored vapors from the second storage device to upstream of a combustion chamber of the engine during a first condition and downstream of the combustion chamber during a second condition. | 09-18-2008 |
20110232611 | AMMONIA VAPOR MANAGEMENT SYSTEM AND METHOD - A method is described for managing vapors generated from an ammonia-containing reductant delivery system. The method may include generating ammonia vapors in a first storage device and storing said generated ammonia vapors in a second storage device. Further, the method may include purging the stored vapors from the second storage device to upstream of a combustion chamber of the engine during a first condition and downstream of the combustion chamber during a second condition. | 09-29-2011 |
Donald M. Lawrence, Birmingham, MI US
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20140060699 | VENTING SYSTEM FOR A DIESEL EXHAUST FLUID FILLER PIPE - A venting system for a filler pipe coupled to a diesel exhaust fluid tank in a vehicle is provided. In one example approach the venting system comprises a plurality of cut-outs in an interior surface of the filler pipe along the interior diameter of the filler pipe in a top surface of the filler pipe. | 03-06-2014 |
Don M. Lawrence, Birmingham, MI US
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20130125997 | METHODS FOR AN EXHAUST FLUID LEVEL SENSOR - Various methods are provided for notifying a vehicle operator of various parameters based on an exhaust fluid level sensor of an exhaust fluid storage tank. In one example, the parameter is a consumption rate of the exhaust fluid. In another example, the parameter is an amount of fluid to be added to the exhaust fluid storage tank. | 05-23-2013 |
Don Mcalpine Lawrence, Birmingham, MI US
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20090313980 | METHOD TO DETECT FUEL VAPORIZER COKING - A method of supplying fuel vapor to an exhaust aftertreatment device of a motor vehicle is provided. The method includes evaporating fuel on a voltage-biased, resistive heating element, the element set in an enclosure configured to release fuel vapor to the exhaust-aftertreatment device, and indicating that the element is degraded if a current flowing through the element is less than a threshold current. In some embodiments, the threshold current is based on the ambient temperature and/or the amount of fuel in the enclosure. | 12-24-2009 |
20130004149 | METHOD TO DETECT FUEL VAPORIZER COKING - A method of supplying fuel vapor to an exhaust aftertreatment device of a motor vehicle is provided. The method includes evaporating fuel on a voltage-biased, resistive heating element, the element set in an enclosure configured to release fuel vapor to the exhaust-aftertreatment device, and indicating that the element is degraded if a current flowing through the element is less than a threshold current. In some embodiments, the threshold current is based on the ambient temperature and/or the amount of fuel in the enclosure. | 01-03-2013 |
Gary Lawrence, Wayne, MI US
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20140192838 | INNOVATIVE BEER GLASS - A drinking glass for beer consumption comprising: an eighteen-ounce volume; a first fill marker; a second fill marker; and a thermometer integrated into the body of the glass. In one particular embodiment, the first fill marker indicates a 16-ounce fill level and the second fill marker indicates a 4-ounce fill level. The thermometer may be positioned at the 4-ounce fill level as a indicator of the 4-ounce fill level. | 07-10-2014 |
John E. Lawrence, Ypsilanti, MI US
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20090071546 | LOW-PROFILE, LESS CONSPICUOUS RETRACTABLE GARDEN HOSE REEL - Low-profile garden hose storage apparatus comprises a housing adapted for mounting onto an exterior wall of a building to store a garden house having first and second ends and an outer diameter ‘d’. A reel, rotatable in the housing, has a central hub and a pair of plates spaced apart at a distance of 1, 2 or 3 d. In the preferred embodiment the plates are spaced apart at a distance slightly greater than d such that a single layer of hose may be wound thereon in a ‘pancake’ configuration. A water inlet is coupled to the hub through a swivel fitting, enabling the reel to rotate as water is delivered. The first end of the garden hose is coupled to the hub of the reel between the plates, with the second end of the garden hose extending through an opening in the housing. The apparatus further includes a mechanism for automatically winding the garden hose onto the reel between the plates, thereby retracting the hose into the housing through the opening thereof. The outer surface of the housing may be configured to be less conspicuous. For example, the outer surface of the housing may be configured to appear as house siding, brick or cinder block. | 03-19-2009 |
Jon D. Lawrence, Grand Rapids, MI US
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20100058851 | VEHICLE TESTING ASSEMBLY - A compact, modular and versatile vehicle testing assembly for testing at least the brakes of an assembled vehicle comprises a pair of rollers adapted to support a tire of a tire and wheel assembly of a vehicle positioned on the testing assembly, with the pair of rollers being moveable relative to one another to alter the spacing there between. A drive system is connected to one of the rollers to operate as a drive roller for selectively imparting rotational motion to a tire of a vehicle tire and wheel assembly, with the other roller comprising a freewheeling roller to which rotational motion is imparted by a vehicle tire. A brake member is engageable with the freewheeling roller to selectively inhibit rotation of the freewheeling roller. | 03-11-2010 |
Mysliwiec Lawrence, Williamston, MI US
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20110245880 | SPINAL FIXATOR AND METHOD OF USE THEREOF - There is provided an explantable system having at least one pedicle screw, and a fixation plate. The system is a base plate including at least one aperture extending through the base plate screw retaining means sized to fit within the aperture for maintaining screw means therein. The system is designed to be removed after a predetermined period of time. | 10-06-2011 |
Phillip G. Lawrence, Spring Lake, MI US
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20150225076 | PRESSURE JET PROPULSION SYSTEM - The pressure jet propulsion disclosed herein generally includes an air compressor for generating a mass flow of compressed air and a mast mount assembly in fluid communication with the air compressor for receiving and channeling the mass flow of compressed air. A positioning system supports the mast mount assembly and is movable on-demand to relocate the mast mount assembly relative to a center of gravity in response to environmental changes. Furthermore, at least two blades are in fluid communication with the mass flow of compressed air from the movable mast mount assembly, which is discharged through an outlet at an angle relative to an axis of rotation to cause rotation of the blades. | 08-13-2015 |
Reginald Lawrence, Kalamazoo, MI US
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20160135508 | ATTACHED COLLAR GUARD - An attached collar guard positioned against an inner surface of a collared garment comprising an absorbing liner attached against the inner surface of a neck portion of a collar, where the liner is detachable; and at least two fasteners to attach the absorbing liner to the collar, where the fasteners are flat to rest flush against a wearer's neck. The collar guard protects the shirt collar from sweat and moisture thereby preventing staining on the shirt. | 05-19-2016 |
Robert Lawrence, Grand Rapids, MI US
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20100268159 | RETROGRADE CORONARY SINUS PERFUSION CANNULA AND METHODS OF USING SAME - A retrograde coronary sinus perfusion catheter including a tubular catheter body having a proximal end, a distal end, and an inner lumen, and an inflatable balloon spaced proximally from the distal end of the catheter body, wherein the balloon is echogenically enhanced. | 10-21-2010 |
Robert J. Lawrence, Grand Rapids, MI US
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20140071701 | METHOD FOR MAKING A LIGHT HANDLE COVER - A method of making a light handle cover including providing a first mold tool and a second mold tool. The first mold tool engages with the second mold tool to form a mold cavity. The mold cavity is injected with a moldable material. The light handle cover is formed as a single integral piece with a substantially cylindrical grab portion that is circumscribed on one end by a substantially circular base shield. A plurality of teeth are formed in the light handle cover. Each of the plurality of teeth is separated by a space. The light handle cover is ejected from the second mold tool with a burst of air. | 03-13-2014 |
20140252680 | METHOD FOR MAKING A LIGHT HANDLE COVER - A method of making a light handle cover including providing a first mold tool and a second mold tool. The first mold tool engages with the second mold tool to form a mold cavity. The mold cavity is injected with a moldable material. The light handle cover is formed as a single integral piece with a substantially cylindrical grab portion that is circumscribed on one end by a substantially circular base shield. A plurality of teeth are formed in the light handle cover. Each of the plurality of teeth is separated by a space. The light handle cover is ejected from the second mold tool with a burst of air. | 09-11-2014 |
Scott Lawrence, Kalamazoo, MI US
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20150327777 | TISSUE MONITORING APPARATUS AND SYSTEM - A tissue monitoring device for selecting, administering or adjusting a treatment based on information obtained by monitoring the tissue. The device includes a substrate for applying to the tissue, for example, a human or an animal external, or internal tissue, including vascular tissue; a light source supported by the substrate, the light source emitting light of a first frequency for directing the emitted light onto a surface of the tissue; a photodetector carried by the substrate spaced from the light source for detecting scattered light, wherein the scattered light is the emitted light scattered by the tissue; and a controller in communication with the photodetector and the light source. | 11-19-2015 |
Theodore S. Lawrence, Ann Arbor, MI US
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20120190622 | INHIBITORS OF THE EPIDERMAL GROWTH FACTOR RECEPTOR-HEAT SHOCK PROTEIN 90 BINDING INTERACTION - Provided herein are compounds that inhibit a binding interaction between an epidermal growth factor receptor (EGFR) and a heat shock protein 90 (HSP90), as well as compositions, e.g., pharmaceutical compositions, comprising the same, and related kits. In some embodiments, the compound is an antibody or antibody analog, and, in other embodiments, the compound is a peptide or peptide analog. Also provided are methods of using the compounds, including methods of increasing degradation of an EGFR, methods of treating cancer, and methods of sensitizing tumors to radiation therapy. | 07-26-2012 |
20150218277 | Inhibitors of the Epidermal Growth Factor Receptor- Heat Shock Protein 90 Binding Interaction - Provided herein are compounds that inhibit a binding interaction between an epidermal growth factor receptor (EGFR) and a heat shock protein 90 (HSP90), as well as compositions, e.g., pharmaceutical compositions, comprising the same, and related kits. In some embodiments, the compound is an antibody or antibody analog, and, in other embodiments, the compound is a peptide or peptide analog. Also provided are methods of using the compounds, including methods of increasing degradation of an EGFR, methods of treating cancer, and methods of sensitizing tumors to radiation therapy. | 08-06-2015 |
Timothy Scott Lawrence, Lake Orion, MI US
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20130214563 | Frame for open roof construction - A frame for an open roof construction is provided, said frame comprising at least one channel member for guiding a drive member, such as a drive cable. Said channel member, as seen in cross section, comprises a base part which is defined by a corresponding local depression of the frame and a cover part connected to said base part. The connection between said base part and said cover part is continuous over the length of said channel member. It is possible that the cover part is connected to the base part through die slide injection molding. | 08-22-2013 |