Quinn, MA
Anthony Quinn, Lexington, MA US
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20150098933 | TRUNCATED LYSOSOMAL ACID LIPASE - Recombinant human lysosomal acid lipase (rhLAL) containing an N-terminal truncation, a composition of truncated recombinant human LAL (TLAL), an isolated mixture comprising TLAL and at least one other form of rhLAL are disclosed. A method of purifying TLAL from a mixture of LAL proteins, pharmaceutical compositions comprising TLAL and methods of producing TLAL are further disclosed. | 04-09-2015 |
Anthony Quinn, Gloucester, MA US
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20140154774 | NPP1 FUSION PROTEINS - The present invention provides a novel fusion polypeptide containing a catalytic domain of NPP1 fused to a targeting moiety, nucleic acids encoding the fusion polypeptide, a vector containing the nucleic acid integrated thereinto, a host cell transformed with the vector and pharmaceutical compositions comprising the fusion polypeptide. | 06-05-2014 |
20150024460 | NPP1 FUSION PROTEINS - The present invention provides a novel fusion polypeptide containing a catalytic domain of NPP1 fused to a targeting moiety, nucleic acids encoding the fusion polypeptide, a vector containing the nucleic acid integrated thereinto, a host cell transformed with the vector and pharmaceutical compositions comprising the fusion polypeptide. | 01-22-2015 |
20150030582 | Lysosomal Storage Disease Enzyme - The present invention provides compositions of recombinant human lysosomal acid lipase having particular glycosylation patterns for internalization into target cells, a vector containing the nucleic acid encoding human lysosomal acid lipase, a host cell transformed with the vector, pharmaceutical compositions comprising the recombinant human lysosomal acid lipase and method of treating conditions associated with lysosomal acid lipase deficiency. | 01-29-2015 |
Anthony Quinn, Chestnut Hill, MA US
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20120064055 | Methods for Treating Lysosomal Acid Lipase Deficiency in Patients - The present invention provides methods of treating LAL deficiency comprising administering to a mammal a therapeutically effective amount of lysosomal acid lipase with an effective dosage frequency. Methods of improving growth and liver function, increasing LAL tissue concentration, and increasing LAL activity in a human patient suffering from LAL deficiency are also provided. | 03-15-2012 |
20130209436 | LYSOSOMAL STORAGE DISEASE ENZYMES - The present invention provides compositions of recombinant human lysosomal acid lipase having particular glycosylation patterns for internalization into target cells, a vector containing the nucleic acid encoding human lysosomal acid lipase, a host cell transformed with the vector, pharmaceutical compositions comprising the recombinant human lysosomal acid lipase and method of treating conditions associated with lysosomal acid lipase deficiency. | 08-15-2013 |
20130273021 | NPP1 FUSION PROTEINS - The present invention provides a novel fusion polypeptide containing a catalytic portion of NPP1 fused to a targeting moiety, nucleic acids encoding the fusion polypeptide, a vector containing the nucleic acid integrated thereinto, a host cell transformed with the vector and pharmaceutical compositions comprising the fusion polypeptide. | 10-17-2013 |
20140255383 | RECOMBINANT HUMAN NAGLU PROTEIN AND USES THEREOF - The present invention provides compositions comprising an isolated mixture of recombinant human NaGlu proteins in which a substantial amount of the NaGlu proteins in the mixture has increased levels of phosphorylated mannose that confer the proteins to be efficiently internalized into human cells. The present invention also provides methods of producing such mixture of NaGlu proteins, vectors used in transgenesis and expression, host cells harboring such vectors, and methods of isolating and purifying the mixture of NaGlu proteins. The invention further provides methods of treating NaGlu associated diseases. | 09-11-2014 |
20140348752 | METHODS FOR TREATING LYSOSOMAL ACID LIPASE DEFICIENCY IN PATIENTS - The present invention provides methods of treating LAL deficiency comprising administering to a mammal a therapeutically effective amount of lysosomal acid lipase with an effective dosage frequency. Methods of improving growth and liver function, increasing LAL tissue concentration, and increasing LAL activity in a human patient suffering from LAL deficiency are also provided. | 11-27-2014 |
20140377859 | NPP1 FUSION PROTEINS - The present invention provides a novel fusion polypeptide containing a catalytic portion of NPP1 fused to a targeting moiety, nucleic acids encoding the fusion polypeptide, a vector containing the nucleic acid integrated thereinto, a host cell transformed with the vector and pharmaceutical compositions comprising the fusion polypeptide. | 12-25-2014 |
20160051638 | METHODS FOR TREATING LYSOSOMAL ACID LIPASE DEFICIENCY IN PATIENTS - The present invention provides methods of treating LAL deficiency comprising administering to a mammal a therapeutically effective amount of lysosomal acid lipase with an effective dosage frequency. Methods of improving growth and liver function, increasing LAL tissue concentration, and increasing LAL activity in a human patient suffering from LAL deficiency are also provided. | 02-25-2016 |
Anthony G. Quinn, Chestnut Hill, MA US
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20100312732 | METHODS AND SYSTEMS FOR RESPONSE DETECTION AND EFFICACY - Techniques are provided for analyzing clinical trial data and other medical information in order to understand heterogeneity of response within a population to a treatment under study. These techniques can support the development of personalized medical treatments and provide a better understanding of variability within the population to the effects of existing and new therapies. Additionally, these techniques can robustly define how subjects in the population respond to a treatment under study to differentiate between different responses, such as non-response and response followed by relapse. Therefore, the likely biology that is different in these responses can be identified to predict future response using any number of identified markers. | 12-09-2010 |
Barbara J. Quinn, Framingham, MA US
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20090313740 | Camouflage U.S. Marine Corps combat utility uniform: pattern, fabric, and design - A camouflage system to be used for both military uniforms and equipment. The system includes specialized means of printing the camouflage system unto fabric. The system can also be used for civilian applications, particularly with sportsman hunters. The system provides camouflage in both the human visible light range and the infrared. The system depends on the use of a macro-pattern resulting from a repeat of a micro-pattern. When applied to fabric, a polyamide-cotton fiber blend has a macro pattern resulting from a repeat of a micro pattern printed on at least one surface. The coloring system used comprises at least four colorings from dyes that in combination produce a percent reflectance value comparable to the negative space of the surroundings near the camouflaged subject. The system functions by a macro pattern being disruptive of the shape of the subject and a micro pattern comprising sharp edge units of a size capable of blending the subject into the background. The relative lightness values and percentages of total pattern are sufficient to produce a percent reflectance of acceptable colors, wet or dry in terms of lightness values compared to current military four-color camouflage. On fabric, the results are achieved by printing A macro pattern that disrupts the sensed shape and a micro pattern with a repeat size that produces the macro pattern. The reflectance of the material is comparable to the negative space surrounding a subject so the subject does not appear too dark or too light (out of place). The variation in the lightness between wet and dry is not greater than 17-28%, achieved during the printing process. | 12-24-2009 |
Barbara Jean Quinn, Framingham, MA US
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20140305982 | CENTRAL OSTEOARTICULAR RELIEF AND PERFORMANCE STRUCTURED LOAD DISTRIBUTION SYSTEM DEVICE AND MODULAR SCALABLE VEST SYSTEM - The present invention is a loadbearing device known by the Applicants' as the “Central Osteoarticular Relief and Performance Structured Load Distribution System” (“CORPS-LDS”), which is worn by a user to help distribute the weight of a load being carried or borne by the user. More specifically, the weight is substantially shifted from the user's shoulders to their hips while not overly inhibiting the user's range of motion. Furthermore, it is an aspect of the CORPS-LDS to distribute the weight being carried in a manner that reduces the strain on the spine and back while lessening the metabolic expenditure of the user. Moreover, the present invention is a protective vest system that utilizes the present invention's CORPS-LDS. | 10-16-2014 |
Casey Quinn, Northampton, MA US
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20160071113 | Evidence Assessment Systems and Interactive Methods - A method for assessing evidence includes receiving a user request to summarize an ability of the evidence to satisfy agency requirements of one or more agencies. Each of the one or more agencies has a plurality of evidence requirements categorized into one or more domains of a plurality of pre-defined domains. For each combination of an agency from the one or more agencies and a domain from the plurality of the domains, a visual indicator reflecting the ability of the evidence to satisfy at least one evidence requirement of the agency in the domain is generated. An interactive map comprising the generated visual indicators arranged by agencies and domains is rendered on a display device. The interactive map is configured such that a selection of a visual indicator on the map causes information related to the visual indicator to be rendered on the display device. | 03-10-2016 |
Daniel Quinn, East Wareham, MA US
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20120327539 | ASSEMBLY OF ELECTRIC MOTOR STARTER COMPONENTS - Techniques disclosed herein include systems and methods for assembly of electric motor starter connecting packages that enable increased automation and reduced assembly via top-down assembly of circuit components, thereby allowing robotic placement, connection, and securing of circuit components. The connecting package can include an electric motor starter, with optional overload protector, packaged as one unit. The motor starter can include an electrical circuit containing a triac, current transformer, Positive Temperature Coefficient (PTC) element, resistor, and a capacitor. A cover and base of the connecting package enclose and firmly secure connected circuit elements without needing a circuit board or filler material. The device design enables quick testing of the motor starter circuit and circuit elements after being enclosed by the housing. | 12-27-2012 |
Daniel R. Quinn, Littleton, MA US
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20150282790 | ENDOSCOPIC CLOSURE DEVICE - A tissue closure device includes a clip including arms extending from proximal ends connected to one another to distal ends. The clip is biased toward an open configuration in which the distal ends extend away from a longitudinal axis of the clip. The arms are held in a closed configuration in which the arms are moved toward the longitudinal axis via an interior surface of a working channel through which the clip is passed until the clip is moved distally past a distal end of the working channel and permitted to revert to the biased open configuration so that the distal ends are positioned about a portion of tissue surrounding a tissue opening to be closed. The device also includes a locking element movable over the arms to lock the clip in the closed configuration in which the arms are drawn toward one another to grip tissue therebetween. | 10-08-2015 |
20150327863 | ZIP CLIP - A tissue closure device includes a first clip including a first longitudinal element extending along a longitudinal axis from a proximal end to a distal end and a first pair of arms extending laterally from the first longitudinal element, the first pair of arms movable between an open configuration in which free ends of the first pair of arms are separated from one another and a closed configuration in which the free ends of the first pair of arms extend toward one another, the first pair of arms being biased toward the closed configuration, and a sliding element extending from a proximal end to a distal end and longitudinally movable relative to the first clip so that when a portion of the sliding element is received between the first pair of arms, the first pair of arms is moved from the biased closed configuration to the open configuration. | 11-19-2015 |
20160081675 | HELICAL DRIVEN ROTATING TISSUE COLLECTION - A device for collecting a tissue sample includes an outer sheath extending from a proximal end to a distal end and including a lumen extending therethrough. The device also includes a needle movably housed within the outer sheath. The needle extends from a proximal end to a serrated distal end and including a channel extending therethrough. The needle is longitudinally movable relative to the outer sheath between an insertion configuration, in which the distal end of the needle is proximal of the distal end of the outer sheath, and a tissue collecting configuration, in which the distal end of the needle extends distally past the distal end of the outer sheath to penetrate tissue and collect a tissue sample in the channel. In addition, the device includes a drive mechanism rotating a distal portion of the needle about a longitudinal axis thereof as the needle is moved between the insertion and tissue collecting configurations. | 03-24-2016 |
20160081678 | HINGED NEEDLE - A device for collecting a tissue sample includes a needle extending longitudinally from a proximal end to a distal end and including a channel extending therethrough, the distal end including a pair of jaws, at least a first one of the jaws being movable relative to the other between an open configuration, in which the jaws are open to receive tissue therebetween, and a closed configuration in which the jaws are drawn toward one another to collect a tissue sample therein. | 03-24-2016 |
Daniel Robert Quinn, Littleton, MA US
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20150238194 | HEMOSTASIS DEVICES AND METHODS UTILIZING MECHANICAL METHODS - A device for causing hemostasis includes an elongated body extending from a first end to a second end, a first clipping anchor coupled to the first end of the elongated body and being movable between a radially contracted insertion configuration and a radially expanded tissue engagement configuration and a second clipping anchor coupled to the second end of the elongated body and being movable between a radially contracted insertion configuration and a radially expanded tissue engagement configuration. The first clipping anchor is movable along a longitudinal axis of the elongated body one of toward and away from the second clipping anchor. | 08-27-2015 |
20150238301 | HEMOSTASIS AND CLOSURE METHODS UTILIZING MESH - A device for causing hemostasis includes a sheet of mesh stretchable between an expanded and a retracted configuration, a size of the sheet in the retracted configuration being selected to cover a target tissue site; a spring mechanism coupled to the mesh, the spring mechanism moving between an expanded configuration and a retracted configuration when the mesh is moved between the expanded and retracted configurations; and a plurality of hooks coupled to the mesh and oriented to extend into tissue to lock the mesh in position when the mesh is placed in a desired position over the target tissue site in the expanded configuration. The hooks are lockingly engaging the target tissue so that, after the hooks have lockingly engaged the tissue, the spring mechanism reverts to the retracted configuration drawing the engaged portions of tissue radially inward. | 08-27-2015 |
David J. Quinn, Cambridge, MA US
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20110289043 | COMPUTATIONAL METHODS AND COMPOSITIONS - The invention in some aspects relates to methods, devices and compositions for evaluating material properties, such as mechanical and rheological properties of substances, particularly biological substances, such as cells, tissues, and biological fluids. In some aspects, the invention relates to methods, devices and compositions for evaluating material properties of deformable objects, such as cells. In further aspects, the invention relates to methods, devices and compositions for diagnosing and/or characterizing disease based on material properties of biological cells. | 11-24-2011 |
Deborah Quinn, Nahant, MA US
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20110190313 | Treatment of Pulmonary Arterial Hypertension - The present invention pertains to the use of 4-(4-methylpiperazin-1-ylmethyl)-N-[4-methyl-3-(4-pyridin-3-yl)pyrimidin-2-ylamino)phenyl]-benzamide or a pharmaceutically acceptable salt thereof or a pyrimidylaminobenzamide of formula I | 08-04-2011 |
Donovan Quinn, Cambridge, MA US
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20140180217 | LIMITER FOR A DISPENSING DEVICE - A limiter for a dispensing device is provided. The limiter includes a body ( | 06-26-2014 |
Hubert Quinn, Brighton, MA US
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20100071444 | High Throughput Screening, Purification and Recovery System for Large and Small Molecules - The present invention relates to a method and apparatus for chromatographically analyzing/purifying samples in a detector, comprising an autosampler to contain a sample for chromatographic analysis and a chromatographic system comprising a loading pump, and an eluting pump and at least one chromatography column. A detector is included for detecting compounds in the sample from the chromatography system. The loading pump establishes a flow of a loading solvent through the autosampler to dissolve the sample and to load the sample on the chromatography column. The eluting pump establishes a flow of eluent of increasing strength through the column and to the detector. In addition, the present invention provides improved methods of screening and preparative chromatography. | 03-25-2010 |
Hubert M. Quinn, Brighton, MA US
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20080307861 | Method For Screening Mobile Phases In Chromatography Systems - A method and system of screening or selecting a mobile phase eluent for a chromatography column is provided. A sample for chromatographic analysis or purification is combined with a solvent and passed through a membrane. A pressure measurement is taken of the sample/solvent combination in the system prior to the membrane. The pressure measurement may be compared to a second pressure and an appropriate solvent may be selected based on the relationship between the first measured pressure and the second pressure. | 12-18-2008 |
Ian Winston Quinn, Waltham, MA US
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20100289484 | MULTI-POSITION SWITCH HAVING DUAL OUTPUT HALL DEVICE - A multi-output switch includes a dipole magnet configured to move from a central position to either a first position or a second position and a Hall Effect sensor having a first sensitive area with a first output and a second sensitive area with a second output, wherein the sensor is relatively positioned such that when the magnet is in the central position, the first output and second output read off, when the magnet is in the first position the first sensitive area is activated and the first output reads on, and when the magnet is in the second position the second sensitive area is activated and the second output reads on. The switch may further include a magnet holder configured to house the magnet and define a pathway of movement for the magnet. | 11-18-2010 |
Ian Winston Quinn, Concord, MA US
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20130032457 | PUSHBUTTON SWITCH - A pushbutton switch configured to switch a mains voltage or line voltage while providing a tactile feedback to a user. The pushbutton switch includes a base having a plurality of fixed contacts, a movable contact having a plurality of contact points fitted within the base and configured to move from an open position to a closed position, a resilient actuator configured to receive and transfer a first pressure to the movable contact and shaped to provide a tactile feedback in response to the first pressure, and a retaining structure secured to the base and comprising a through-hole through which at least a portion of the actuator protrudes. In the pushbutton switch, conducting components on the movable contact and the plurality of fixed contacts are spaced apart such that the pushbutton switch is configured and rated to switch a line voltage. | 02-07-2013 |
Joseph P. Quinn, Norfolk, MA US
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20150293737 | NAVIGATIONAL CHART WITH REAL-TIME DEPTH INFORMATION AND SAFETY BOUNDARIES - An apparatus for displaying a navigational chart such as a navigational chart plotter includes real-time depth indicators displayed at corresponding locations on the navigational chart. The real time depth indicators display a real time water depth of each of the corresponding locations. The real time water depths are generated based on a predetermined depth of the corresponding location at a predetermined time relative to a tide cycle combined with a projected tide height at a selected time. Real-time safety boundaries may also be displayed for vessels of a defined draft based on the real-time depths information. | 10-15-2015 |
Joseph Patrick Quinn, Norfolk, MA US
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20140217927 | TEMPERATURE DEPENDENT HYBRID LIGHT BULB - A hybrid light bulb is configured to automatically select a low heat emitting (low power) mode such as a CFL bulb portion when ambient temperature is above a predetermined threshold, and to select a high heat emitting (conventional incandescent or halogen bulb) portion when ambient temperature is below the predetermined threshold | 08-07-2014 |
Matt Quinn, Boston, MA US
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20090327036 | DECISION SUPPORT SYSTEMS USING MULTI-SCALE CUSTOMER AND TRANSACTION CLUSTERING AND VISUALIZATION - Systems, methods and consumer-readable media for using multi-scale customer and transaction clustering and visualization according to the invention have been provided. Systems and methods according to the invention may use program code to obtain customer transaction data and categorize obtained customer transaction data. The systems and methods may also analyze the categorized customer transaction data in order to identify patterns among the data. The systems and methods may also use the identified patterns to isolate a selected number of behavioral factors and group customers into population segments based on the behavioral factors. | 12-31-2009 |
Matthew T. Quinn, Arlington, MA US
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20100206194 | Printer Pallet Assembly for Use in Printing Multiple Articles of Manufacture - A pallet assembly for use in simultaneously printing multiple articles of manufacture. The assembly includes a pallet having a support surface, a carrier mountable onto the pallet and conforming with the pallet surface features (e.g., individual article of manufacture platforms) such that individual articles of manufacture may be place on the support surface(s) of the pallet yet the carrier substantially covers the remaining areas of the top surface of the pallet to protect the pallet from unintentional application of ink by the printer. The carrier also includes supports which allow a carrier loaded with articles of manufacture to be lifted off of the pallet and carried away for further processing. The assembly may also include a positioner which is mountable over the carrier on the pallet. The positioner operates as a jig for aligning each of the articles of manufacture in proper position on the support surface of the pallet. | 08-19-2010 |
20130038011 | PRINTER PALLET ASSEMBLY FOR THE USE IN PRINTING MULTIPLE ARTICLES OF MANUFACTURE - A pallet assembly for use in simultaneously printing multiple articles of manufacture. The assembly includes a pallet having a support surface, a carrier mountable onto the pallet and conforming with the pallet surface features (e.g., individual article of manufacture platforms) such that individual articles of manufacture may be place on the support surface(s) of the pallet yet the carrier substantially covers the remaining areas of the top surface of the pallet to protect the pallet from unintentional application of ink by the printer. The carrier also includes supports which allow a carrier loaded with articles of manufacture to be lifted off of the pallet and carried away for further processing. The assembly may also include a positioner which is mountable over the carrier on the pallet. The positioner operates as a jig for aligning each of the articles of manufacture in proper position on the support surface of the pallet. | 02-14-2013 |
20130174012 | AUTOMATED GENERATION OF MOBILE OPTIMIZED WEBSITE - Methods and apparatuses for automatically generating a mobile-optimized website from an existing website are disclosed. | 07-04-2013 |
Paul Quinn, Wellesley, MA US
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20150215172 | Service-Function Chaining - Presented herein are service-function chaining techniques. In one example, a service controller in a network comprising a plurality of service nodes receives one is configured to identify one or more service-functions hosted by each of the service nodes. The service controller defines a service-function chain in terms of service-functions to be applied to traffic in the network and provides information descriptive of the service-function chain to a classifier node. | 07-30-2015 |
20150263901 | SERVICE NODE ORIGINATED SERVICE CHAINS IN A NETWORK ENVIRONMENT - An example method for service node originated service chains in a network environment is provided and includes receiving a packet at a service node in a network environment that includes a plurality of service nodes and a central classifier, analyzing the packet for a service chain modification or a service chain initiation, classifying the packet at the service node to a new service chain based on the analysis, initiating the new service chain at the service node if the analysis indicates service chain initiation, and modifying an existing service chain for the packet to the new service chain if the analysis indicates service chain modification. In specific embodiments, the analysis includes applying classification logic specific to the service node. Some embodiments, service node attributes and order of service nodes in substantially all service chains configured in the network may be received from a central controller. | 09-17-2015 |
20150281173 | DYNAMIC SERVICE CHAIN WITH NETWORK ADDRESS TRANSLATION DETECTION - In one embodiment, a method includes receiving a packet associated with a flow at a network device, classifying the packet at the network device based on information received from a policy layer, inserting a Network Address Translation (NAT) indicator for the flow into the packet, and transmitting the packet in a service chain comprising network address translation. The NAT indicator is associated with the flows before and after network address translation to provide symmetry between the service chain and a return traffic service chain. An apparatus and logic are also disclosed herein. | 10-01-2015 |
20150295831 | NETWORK ADDRESS TRANSLATION OFFLOAD TO NETWORK INFRASTRUCTURE FOR SERVICE CHAINS IN A NETWORK ENVIRONMENT - An example method for network address translation (NAT) offload to network infrastructure for service chains in a network environment is provided and includes receiving a packet at a network infrastructure in a network comprising a plurality of service nodes interconnected through the network infrastructure, each service node executing at least one service function, identifying the packet as belonging to a first flow based on a cookie in a network service header of the packet that indicates a service chain that includes a sequence of service functions to be executed on the packet at the service nodes, determining that a service function in the service chain is to be offloaded from one of the service nodes to the network infrastructure for subsequent packets of the first flow, and executing the offloaded service function at the network infrastructure for subsequent packets of the first flow. | 10-15-2015 |
20150334027 | SYSTEM AND METHOD FOR TRANSPORTING INFORMATION TO SERVICES IN A NETWORK ENVIRONMENT - An example method is provided in one example embodiment and may include receiving a packet for a subscriber at a gateway, wherein the gateway includes a local policy anchor for interfacing with one or more policy servers and one or more classifiers for interfacing with one or more service chains, each service chain including one or more services accessible by the gateway; determining a service chain to receive the subscriber's packet; appending the subscriber's packet with a header, wherein the header includes, at least in part, identification information for the subscriber and an Internet Protocol (IP) address for the local policy anchor; and injecting the packet including the header into the service chain determined for the subscriber. | 11-19-2015 |
20150334595 | SYSTEM AND METHOD FOR TRANSPORTING INFORMATION TO SERVICES IN A NETWORK ENVIRONMENT - An example method is provided in one example embodiment and may include receiving a packet for a subscriber at a gateway, wherein the gateway includes a local policy anchor for interfacing with one or more policy servers and one or more classifiers for interfacing with one or more service chains, each service chain including one or more services accessible by the gateway; determining a service chain to receive the subscriber's packet; appending the subscriber's packet with a header, wherein the header includes, at least in part, identification information for the subscriber and an Internet Protocol (IP) address for the local policy anchor; and injecting the packet including the header into the service chain determined for the subscriber. | 11-19-2015 |
20150358850 | CONVEYING SUBSCRIBER INFORMATION TO SERVICE CHAIN SERVICES USING TUNNEL PROTOCOL HEADER ENCAPSULATION FOR MOBILE NETWORK APPLICATIONS IN A NETWORK ENVIRONMENT - A method provided in one embodiment includes receiving, at a first network element, a first data packet of a data flow, wherein the data flow is associated with a subscriber. The method further includes receiving subscriber information associated with the subscriber, and encapsulating the subscriber information with the first data packet to form an encapsulated data packet. The method still further includes determining a service chain including one or more services to which the encapsulated data packet is to be forwarded, and forwarding the encapsulated data packet to the service chain. | 12-10-2015 |
Susan Elizabeth Quinn, Norwood, MA US
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20100113474 | Antineoplastic Combinations of 4-Anilino-3-Cyanoquinolines and Capecitabine - A combination of a 4-anilino-3-cyanoquinoline compound (e.g. HKI-272, SKI-606, EKB-569) and a capecitabine compound in the treatment of a neoplasm is provided. Regimens, kits, and methods for treatment of neoplasm, including breast cancer including metastatic breast cancer, and lung cancer, using this combination, optionally in combination with other anti-neoplastic agents, or immune modulators are also described. | 05-06-2010 |
20140171384 | ANTINEOPLASTIC COMBINATIONS OF 4-ANILINO-3-CYANOQUINOLINES AND CAPECITABINE - A combination of a 4-anilino-3-cyanoquinoline compound (e.g. HKI-272, SKI-606, EKB-569) and a capecitabine compound in the treatment of a neoplasm is provided. Regimens, kits, and methods for treatment of neoplasm, including breast cancer including metastatic breast cancer, and lung cancer, using this combination, optionally in combination with other anti-neoplastic agents, or immune modulators are also described. | 06-19-2014 |
William Quinn, Swampscott, MA US
William R. Quinn, Swampscott, MA US
Patent application number | Description | Published |
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20090306762 | Braided stent and method for its manufacture - A stent includes regions of differing numbers of braided filaments to provide different dimensions and/or properties in different regions along the stent length. The stent may include a first and second plurality of braided filaments each braided together. The second plurality of braided filaments is braided into the first plurality of braided filaments to form a region of different properties than the first. A method of constructing a braided stent includes the steps of braiding a first plurality of filaments to form the flexible portion, combining a second plurality of filaments to the first plurality of filaments, and then braiding the second plurality of filaments with the first plurality of filaments to form the more rigid region from the combination of the first and second plurality of filaments, where the second plurality of filaments is braided only in the rigid region. | 12-10-2009 |
20110015719 | STENT-GRAFT WITH ADJUSTABLE LENGTH - A stent-graft comprising a stent and a graft having a supported portion lining or covering at least a portion of the stent, and an unsupported portion extending proximally beyond the proximal end of the stent. The stent-graft may have a length corresponding to at least a mean standard length from a standard incision point to a distal-most portion of a standard lumen into which the distal end of the stent is adapted to be deployed, with the unsupported portion of the graft extending beyond the mean standard length by an amount equal to at least two, if not three or more, standard deviations of the mean standard length. A method for deploying the stent-graft comprises making an incision in a wall of the lumen, introducing and deploying the stent-graft in the lumen so that the proximal end extends beyond the incision, and attaching the graft to a lumen by anastamosis. | 01-20-2011 |