Patent application number | Description | Published |
20100285015 | TARGETING RECOMBINANT THERAPEUTICS TO CIRCULATING RED BLOOD CELLS - Fusion proteins comprising a single chain antigen-binding domain (scFv) of a monoclonal antibody, linked to an anti-thrombotic agent, anti-inflammatory agent, or a pro-drug thereof are provided, where the polypeptide binds to a binding site (antigen) expressed on the surface of a red blood cell at a density greater than 5,000 copies per red blood cell. Pharmaceutical compositions comprising these fusion proteins, and methods of delivering an anti-thrombotic agent to the surface of a red blood cell via delivery of these fusion proteins, and methods of treating or preventing thrombosis, tissue ischemia, acute myocardial infarction (AMI), ischemic stroke, cerebrovascular disease, pulmonary embolism, or ischemic peripheral vascular disease via administration of the fusion proteins or compositions comprising same are also provided. | 11-11-2010 |
20110262466 | COMPOSITIONS CONTAINING THROMBOMODULIN DOMAINS AND USES THEREOF - Compositions are provided comprising a thrombomodulin domain linked to a targeting moiety that binds to a determinant on the surface of a target endothelial cell or red blood cell, wherein the thrombomodulin domain may be the extracellular domain, the N-terminal lectin-like domain, or an epidermal growth factor (EGF)-like domain. The targeting moiety may be a single chain antigen-binding domain (scFv), and the targeting moiety and thrombomodulin domain of the composition may be linked as a continuous polypeptide chain. Methods of delivery and use of a composition described herein are provided, as well as methods of treating or preventing thrombosis, inflammation, tissue ischemia, sepsis, acute lung injury (ALI), acute myocardial infarction (AMI), ischemic stroke, cerebrovascular disease, pulmonary embolism, or ischemic peripheral vascular disease is provided. | 10-27-2011 |
20130058929 | FUSION PROTEINS FOR INHIBITION AND DISSOLUTION OF COAGULATION OF THROMBI - Fusion proteins containing a ligand which specifically binds to a selected vascular bed linked to an anti-thrombotic molecule are provided. Also provided are methods for use of these fusion proteins to prevent coagulation, to dissolve blood clots and to protect against the risk of iatrogenic side effects including those arising from cancer therapy and specific vascular occluding agents. | 03-07-2013 |
Patent application number | Description | Published |
20090042926 | Niacin Receptor Agonists, Compositions Containing Such Compounds and Methods of Treatment - The present invention encompasses compounds of Formula (I): as well as pharmaceutically acceptable salts and hydrates thereof, that are useful for treating atherosclerosis, dyslipidemias and the like. Pharmaceutical compositions and methods of use are also included. | 02-12-2009 |
20090082340 | 3-SUBSTITUTED-5- AND 6-AMINOALKYL INDOLE-2-CARBOXYLIC ACID AMIDES AND RELATED ANALOGS AS INHIBITORS OF CASEIN KINASE I - The present invention discloses and claims methods for the treatment of a patient suffering from a disease or disorder ameliorated by inhibition of casein kinase Iε activity comprising the administration of a compounds of formula (I) and formula (II) | 03-26-2009 |
20090170891 | Niacin Receptor Agonists, Compositions Containing Such Compounds and Methods of Treatment - The present invention encompasses compounds of Formula I: | 07-02-2009 |
20100144778 | Niacin Receptor Agonists, Compositions Containing Such Compounds and Methods of Treatment - The present invention encompasses compounds of Formula (I): as well as pharmaceutically acceptable salts and hydrates thereof, that are useful for treating atherosclerosis, dyslipidemias and the like. Pharmaceutical compositions and methods of use are also included. | 06-10-2010 |
20100197691 | SOLUBLE EPOXIDE HYDROLASE INHIBITORS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT - Compounds of the Formula: (I) as well as pharmaceutically acceptable salts and hydrates thereof, that are useful for treating hypertension, diabetes, inflammation, atherosclerosis, pain, and the like are disclosed. Pharmaceutical compositions and methods of use are also included. | 08-05-2010 |
20110003849 | SOLUBLE EPOXIDE HYDROLASE INHIBITORS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT - Compounds of the formula: as well as pharmaceutically acceptable salts and hydrates thereof, that are useful for treating diabetes, inflammation, atherosclerosis, hypertension, pain and the like are disclosed. Pharmaceutical compositions and methods of use are also included. | 01-06-2011 |
20120178750 | Niacin Receptor Agonists, Compositions Containing Such Compounds and Methods of Treatment - The present invention encompasses compounds of Formula I: | 07-12-2012 |
20130012511 | SOLUBLE GUANYLATE CYCLASE ACTIVATORS - The invention relates to compounds having the structure of Formula (I) and pharmaceutically acceptable salts thereof, which are soluble guanylate cyclase activators. The compounds are capable of modulating the body's production of cyclic guanosine monophosphate (“cGMP”) and are generally suitable for the therapy and prophylaxis of diseases which are associated with a disturbed cGMP balance. The compounds are useful for treatment or prevention of cardiovascular diseases, endothelial dysfunction, diastolic dysfunction, atherosclerosis, hypertension, pulmonary hypertension, angina pectoris, thromboses, restenosis, myocardial infarction, strokes, cardiac insufficiency, pulmonary hypertonia, erectile dysfunction, asthma bronchiale, chronic kidney insufficiency, diabetes, or cirrhosis of the liver. | 01-10-2013 |
20130023515 | NOVEL SPIROPIPERIDINE PROLYLCARBOXYPEPTIDASE INHIBITORS - Compounds of structural formula (I) are inhibitors of prolylcarboxypeptidase (PrCP). The compounds of the present invention are useful for the prevention and treatment of conditions related to enzymatic activity of PrCP such as abnormal metabolism, including obesity; diabetes; metabolic syndrome; obesity related disorders; and diabetes related disorders. | 01-24-2013 |
20130059830 | NOVEL PROLYLCARBOXYPEPTIDASE INHIBITORS - Compounds of structural formula I are inhibitors of prolylcarboxypeptidase (PrCP). The compounds of the present invention are useful for the prevention and treatment of conditions related to the enzymatic activity of PrCP such as abnormal metabolism, including obesity; diabetes; metabolic syndrome; obesity related disorders; and diabetes related disorders. | 03-07-2013 |
20140031349 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL - The present invention provides compounds of Formula I | 01-30-2014 |
20140206618 | Inhibitors of the Renal Outer Medullary Potassium Channel - The present invention provides compounds of Formula Ia and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and conditions associated with excessive salt and water retention. | 07-24-2014 |
20150099729 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL - The present invention provides compounds of Formula I | 04-09-2015 |
20160002259 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL - The present invention provides compounds of Formula I | 01-07-2016 |
20160024091 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL - The present invention provides compounds of Formula I | 01-28-2016 |
Patent application number | Description | Published |
20130140356 | CAMERA POSITIONING TOOL FOR SYMBOLOGY READING - A method and device for receiving an image of a symbology captured by an imaging device, displaying an image of the symbology, displaying a boundary indicator around the symbology, adjusting the image size to correspond with the boundary indicator, decoding the symbology, and initiating an action by device. | 06-06-2013 |
20130182946 | METHODS AND SYSTEM FOR ANALYZING AND RATING IMAGES FOR PERSONALIZATION - As set forth herein, a computer-implemented method facilitates pre-analyzing an image and automatically suggesting to the user the most suitable regions within an image for text-based personalization. Image regions that are spatially smooth and regions with existing text (e.g. signage, banners, etc.) are primary candidates for personalization. This gives rise to two sets of corresponding algorithms: one for identifying smooth areas, and one for locating text regions. Smooth regions are found by dividing the image into blocks and applying an iterative combining strategy, and those regions satisfying certain spatial properties (e.g. size, position, shape of the boundary) are retained as promising candidates. In one embodiment, connected component analysis is performed on the image for locating text regions. Finally, based on the smooth and text regions found in the image, several alternative approaches are described herein to derive an overall metric for “suitability for personalization.” | 07-18-2013 |
20130215473 | SYSTEM AND METHOD FOR CREATING MACHINE-READABLE CODES IN COMBINATION WITH OTHER IMAGES SUCH AS LOGOS - A process for creating a barcode with an embedded logo considers a printer gamut and divides the printer gamut into multiple regions. A virtual printer gamut is then generated with the colors in bright and dark regions. A target logo image is generated by mapping the virtual gamut to the original logo image. A logo with embedded barcode is produced using the colors specified in the target logo image. | 08-22-2013 |
20130228629 | SYSTEM AND METHOD FOR EMBEDDING MACHINE-READABLE CODES IN COMBINATION WITH OTHER IMAGES SUCH AS LOGOS - A process for embedding a barcode into an image generates an extended barcode that includes a number of copies of the barcode. The extended barcode is embedded into the original image and a textured image is generated. A barcode region is selected that includes a machine-readable copy of the barcode. A transition region is selected that includes a set of pixels that are within a predetermined distance from the barcode region. The textured image is combined with the original image to produce the output image based on the barcode and transition regions. | 09-05-2013 |
20130228630 | SYSTEM AND METHOD FOR EMBEDDING MACHINE-READABLE CODES IN A DOCUMENT BACKGROUND - A method and apparatus are disclosed for embedding a two-dimensional machine-readable code into the background of a document in an aesthetically pleasing manner. The objects (picture, graphics, text, etc.) in a document image are first segmented from the background. A location for embedding the barcode is determined. A texture image is created by replicating the barcode to a size that covers the entire image. A modulation index map is generated from the segmentation results. The original image is modulated to produce the output image based on the texture image and the modulation index map. | 09-05-2013 |
20130266190 | SYSTEM AND METHOD FOR STREET-PARKING-VEHICLE IDENTIFICATION THROUGH LICENSE PLATE CAPTURING - A method and a system for identifying a vehicle in a parking area includes receiving video data from a video camera observing a parking area from a first field of view over duration of time and receiving image data from a still camera observing a second field of view overlapping the first field of view. The method includes tracking a location of a vehicle across a sequence of frames. The tracking includes determining a time instant at which each frame was captured. The method includes comparing a select frame captured by the video camera with an image captured by the still camera. Based on the comparing, the method includes matching the vehicle in the image with the vehicle in the frame. The method includes determining a license plate number of the vehicle by locating a license plate on the vehicle in the image. | 10-10-2013 |
20130293734 | PRODUCT IDENTIFICATION USING MOBILE DEVICE - A method and apparatus for obtaining an image and providing one or more document files to a user. The method may include capturing an image of a target object using an imaging device of an electronic device, analyzing the image to identify a plurality of features and feature locations on the target object with a processor using an image recognition application, accessing a model database to identify an appliance model having features and feature locations that match the identified features and feature locations from the image, retrieving one or more document files that correspond to the identified model from a file database, and providing the one or more document files to a user. | 11-07-2013 |
20130330004 | FINDING TEXT IN NATURAL SCENES - As set forth herein, systems and methods facilitate providing an efficient edge-detection and closed-contour based approach for finding text in natural scenes such as photographic images, digital, and/or electronic images, and the like. Edge information (e.g., edges of structures or objects in the images) is obtained via an edge detection technique. Edges from text characters form closed contours even in the presence of reasonable levels of noise. Closed contour linking and candidate text line formation are two additional features of the described approach. A candidate text line classifier is applied to further screen out false-positive text identifications. Candidate text regions for placement of text in the natural scene of the electronic image are highlighted and presented to a user. | 12-12-2013 |
20130335445 | METHODS AND SYSTEMS FOR REALISTIC RENDERING OF DIGITAL OBJECTS IN AUGMENTED REALITY - A system and method of rendering in real time a virtual object onto a viewfinder display, the method comprising determining one or more scene properties of a scene on a viewfinder display of a device, receiving a virtual object for insertion into the scene, determining a location for placing the virtual object within the scene, determining a first appearance of the virtual object based on the one or more scene properties, and inserting the virtual object with the first appearance into the scene depicted on the viewfinder display of the device based on the location. | 12-19-2013 |
20140043363 | SYSTEMS AND METHODS FOR IMAGE OR VIDEO PERSONALIZATION WITH SELECTABLE EFFECTS - Embodiments relate to systems and methods for image or video personalization with selectable effects. Image data, which can include video sequences or digital still images, can be received in a graphical personalization tool to perform various image processing and related operations to insert personalized objects into the image data. In aspects, the personalized object(s) can be or include graphical inputs such as, for instance, textual information, graphical information, and/or other visual objects. The graphical personalization tool can automatically perform one or more processing stages in the image path, such as identifying key regions in a still image and/or key frames in a video sequence, in which personalized objects will be generated and inserted. Personalized objects can be extended to additional regions of a still image, can be animated across multiple still images, and/or can be extended to additional frames of a video sequence, all on an automated or user-assisted basis. | 02-13-2014 |
20140093131 | VISIBILITY IMPROVEMENT IN BAD WEATHER USING ENCHANCED REALITY - Methods and systems for improving driver visibility during bad weather and/or poor lighting for objects such as road signs, road lines, road markings, etc. The disclosed approach can enhance the captured images by exploiting priori knowledge about the scene and the objects that are stored in a database. In general, the orientation and location of a vehicle can be determined, and data can be retrieved which is indicative of stationary objects that are anticipated to be detectable at a current orientation and location of the vehicle. A captured scene is compared to data retrieved from the database using the information regarding the orientation and the location of the vehicle such that a matching scene indicates where objects are expected to appear in the captured scene and improve driver visibility with respect to the vehicle during poor driving conditions. | 04-03-2014 |
20140118560 | MOBILE DOCUMENT CAPTURE ASSISTANCE USING AUGMENTED REALITY - A method and device for aligning an image of a printed substrate using a mobile device. The method includes receiving, by an image capturing device, an image stream of a printed substrate; determining, by a processing device operably connected to the image capturing device, a location and a geometry of the printed substrate from the image stream; displaying, on a display operably connected to the processing device, the image stream; overlaying, by the processing device, at least a first visual marker onto the printed substrate as displayed in the image stream using the location and geometry; and instructing, by the processing device, a user of the mobile device to move the mobile device to align the mobile device and the printed substrate. The device includes the various hardware components configured to perform the method of aligning. | 05-01-2014 |
20140152849 | VIDEO CAPTURE OF MULTI-FACETED DOCUMENTS - A system captures or otherwise receives a video and uses the video to create an electronic file corresponding to a multi-faceted printed artifact, such as a multi-page document. When the system receives the video, it selects a set of some or all of the video's image frames, determines a frame quality for each frame in the set, and identifies a subset of the frames such that the frame quality of each frame in the subset satisfies one or more image quality criteria. The subset will include at least one frame for each facet of the multi-faceted printed artifact, such as a page of the document. The processor then automatically combines the subset of frames into a single electronic file. | 06-05-2014 |
20140211023 | METHODS AND SYSTEMS FOR DETECTING AN OBJECT BORDERLINE - Methods and systems for detecting an object borderline. A first image with respect to the object can be captured by an image-capturing unit without a flash light and borderlines of the object can be detected. If the detection is successful, the detected borderlines can be outputted. Otherwise, a second image with respect to the object can be captured by the image-capturing unit by applying a flash light and the borderlines can be detected in the image. A geometric transformation between the two images can then be estimated. Finally, the border lines in the first image can be determined by transforming the borderlines detected in the second image. Such an approach effectively detects the appliance borderlines and avoids artifacts caused by applying flash. | 07-31-2014 |
20140313364 | METHOD AND APPARATUS FOR PROCESSING IMAGE OF PATCH PANEL - A method for processing an image of a patch panel includes: a) receiving an initial image; b) determining multiple ports of the patch panel are aligned in a desired orientation in the initial image; c) processing the initial image to identify edge lines perpendicular to the desired orientation; d) processing the edge lines to identify a port hypothesis that includes an estimated port gap between the multiple ports along the desired orientation and an estimated port size for the multiple ports along the desired orientation; e) processing the port hypothesis to determine an estimated port quantity for the multiple ports; and f) processing the port hypothesis to identify an estimation error between expected and detected edge line positions in relation to a reference axis perpendicular to the edge lines. An apparatus associated therewith includes an input/output and pre-processing modules and detection, hypothesis, estimating, and scoring processors. | 10-23-2014 |
Patent application number | Description | Published |
20120325911 | DECODABLE INDICIA READING TERMINAL WITH OPTICAL FILTER - A decodable indicia reading terminal can comprise a housing including a housing window, a multiple pixel image sensor disposed within the housing, an imaging lens configured to focus an image of decodable indicia on the image sensor, an optical bandpass filter disposed in an optical path of light incident on the image sensor, an analog-to-digital (A/D) converter configured to convert an analog signal read out of the image sensor into a digital signal representative of the analog signal, and processor configured to output a decoded message data corresponding to the decodable indicia by processing the digital signal. | 12-27-2012 |
20120325912 | OPTICAL FILTER FOR IMAGE AND BARCODE SCANNING - Methods for using an optical indicia reading terminal including a housing, a multiple pixel image sensor disposed within the housing, an imaging lens assembly configured to focus an image of decodable indicia on the image sensor, an optical bandpass filter disposed in an optical path of light incident on the image sensor, an analog-to-digital (A/D) converter configured to convert an analog signal read out of the image sensor into a digital signal representative of the analog signal, and processor configured to output a decoded message data corresponding to the decodable indicia by processing the digital signal. | 12-27-2012 |
20130146666 | APPARATUS COMPRISING IMAGE SENSOR ARRAY AND ILLUMINATION CONTROL - There is set forth herein an indicia reading apparatus having a configuration in which an illumination assembly for projecting an illumination pattern is de-energized during subsequent exposure periods. In one embodiment the indicia reading apparatus includes a configuration in which the illumination assembly is energized intermediate of the exposure periods. The indicia reading apparatus is useful for reading decodable indicia that is displayed on a display. | 06-13-2013 |
20140124579 | APPARATUS COMPRISING IMAGE SENSOR ARRAY AND ILLUMINATION CONTROL - There is set forth herein an indicia reading apparatus having a configuration in which an illumination assembly for projecting an illumination pattern is de-energized during subsequent exposure periods. In one embodiment the indicia reading apparatus includes a configuration in which the illumination assembly is energized intermediate of the exposure periods. The indicia reading apparatus is useful for reading decodable indicia that is displayed on a display. | 05-08-2014 |
20140131445 | DECODABLE INDICIA READING TERMINAL WITH OPTICAL FILTER - A decodable indicia reading terminal can comprise a housing including a housing window, a multiple pixel image sensor disposed within the housing, an imaging lens configured to focus an image of decodable indicia on the image sensor, an optical bandpass filter disposed in an optical path of light incident on the image sensor, an analog-to-digital (A/D) converter configured to convert an analog signal read out of the image sensor into a digital signal representative of the analog signal, and processor configured to output a decoded message data corresponding to the decodable indicia by processing the digital signal. | 05-15-2014 |
Patent application number | Description | Published |
20140047022 | MANAGING A SHARING OF MEDIA CONTENT AMONG CIENT COMPUTERS - Technology is provided to manage sharing of media content among client computers. In one example, an application server provides at least a portion of the media content to the client computers. The application server receives a requested session event. A session event is an annotation, a comment, or a navigation request. The application server generates a formatted session event by formatting the requested session event at least according at least one option. An option defines how the application server is to modify a session event for display at the client computers. The application server provides the formatted session event to the client computers for display on user interfaces at the client computers. This Abstract is submitted with the understanding that it will not be used to interpret or limit the scope or meaning of the claims. | 02-13-2014 |
20140372904 | SYSTEM AND METHOD FOR COMMUNICATING TRANSPORTATION EVENTS - A system and method for notifying members of a social network of a transit event is disclosed. In one example, the method comprises presenting, to the user in the display of the computer system, a geographical navigation interface including a visual indicator of a transit element, receiving, in the display, at least one long-press input provided by the user and directed to the visual indicator of the transit element, presenting at least one selection option for identifying a transit event pertaining to the transit element and at least one broadcast option for the user's social network, accepting, at least one selection option input corresponding to the transit event and at least one broadcast option input provided by the user, and causing the identified transit event to be broadcast to one or more members of the user's social network, based on the at least one broadcast option input. | 12-18-2014 |
20150193380 | TIME-BASED PRESENTATION EDITING - Systems and methods are disclosed herein for time-based editing of an electronic presentation. An electronic presentation editing interface for editing an electronic presentation is provided. The interface includes a digital canvas including multiple canvas objects in multiple canvas layers and a digital timeline including multiple timeline objects. Each canvas object is linked to a timeline object, and a location of a timeline object on the digital timeline is indicative of a time and a canvas layer that each linked canvas object is displayed on the digital canvas. | 07-09-2015 |
20150200893 | DOCUMENT REVIEW SYSTEM - In response to a user request, a server identifies and facilitates communication with a third-party collaborator who may not be known to the user. Potential collaborators are identified by familiarity with a subject matter of a document or user request. The potential third-party collaborator is allowed to see the context of the user request, and the user may ask a third-party collaborator a follow-up question. | 07-16-2015 |
Patent application number | Description | Published |
20110097330 | Novel Gene Disruptions, Compostitions and Methods Relating Thereto - The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO179, PRO181, PRO244, PRO247, PRO269, PRO293, PRO298, PRO339, PRO341, PRO347, PRO531, PRO537, PRO718, PRO773, PRO860, PRO871, PRO872, PRO813, PRO828, PRO1100, PRO1114, PRO115, PRO1126, PRO1133, PRO1154, PRO1185, PRO1194, PRO1287, PRO1291, PRO1293, PRO1310, PRO1312, PRO1335, PRO1339, PRO2155, PRO1356, PRO1385, PRO1412, PRO1487, PRO1758, PRO1779, PRO1785, PRO1889, PRO90318, PRO3434, PRO3579, PRO4322, PRO4343, PRO4347, PRO4403, PRO4976, PRO260, PRO6014, PRO6027, PRO6181, PRO6714, PRO9922, PRO7179, PRO7476, PRO9824, PRO19814, PRO19836, PRO20088, PRO70789, PRO50298, PRO51592, PRO1757, PRO4421, PRO9903, PRO1106, PRO1411, PRO1486, PRO1565, PRO4399 or PRO4404 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities. | 04-28-2011 |
Patent application number | Description | Published |
20080228319 | ROBOTIC ARM ALIGNMENT - A method for aligning the position of a movable arm includes: providing an alignment element on the apparatus projecting a distance above the apparatus in the z-direction and having a surface lying in a plane formed by an x and y axis; providing a movable arm having a tool at the free end; positioning the object such that the surface of the element faces the tool; moving the tool in a direction towards the surface of the element; sensing when the tool reaches a predetermined point on or above the surface of the element, whereby the position of the tool in the z-direction is determined based on the relationship between the measured response of the tool and the height of the tool above the surface of the alignment element; placing the tool on or at a distance in the z-direction from the surface; moving the tool in the x-direction while sensing the surface of the element; moving the tool in the x-direction until an edge of the element is sensed; determining the center in the x-direction based on the known distance the tool has moved and the known dimensions of the element in the x-direction; placing the tool on or at a distance in the z-direction from the surface; moving the tool in the y-direction while sensing the surface of the element; moving the tool in the y-direction until an edge of the element is sensed; determining the center in the y-direction based on the known distance the tool has moved and the known dimensions of the element in the y-direction. In a preferred embodiment, the tool is a metering probe having a disposable tip on the end thereof. In another preferred embodiment, the measured response is the air pressure in the probe and the metering probe has a source of compressed air for expelling air out of the end of the probe and a pressure transducer for measuring the air pressure inside the metering probe. | 09-18-2008 |
20090093065 | ASPIRATING AND DISPENSING SMALL VOLUMES OF LIQUIDS - A metering device for aspirating and dispensing a liquid includes a housing; a pumping medium, preferably a gas containing chamber contained within the housing; a channel having a proximate end in fluid communication with the chamber and a distal end in fluid communication with an external environment; a heat or cold source providing a source of heat or cold to the gas containing chamber; and a temperature sensor for measuring the temperature inside the chamber. In a preferred embodiment, the device further includes a pressure sensor for measuring gas pressure inside the chamber, or multiple chambers. A method for aspirating and dispensing a liquid includes: providing a metering device for aspirating and dispensing a liquid that includes a housing; a gas containing chamber contained within the housing, the chamber; a channel having a proximate end in fluid communication with the chamber and a distal end in fluid communication with an external environment; a heat or cold source providing a source of heat or cold to the gas containing chamber; and a temperature sensor for measuring the temperature inside the chamber; providing a source of liquid to be aspirated; bringing the distal end of the channel into contact with the liquid; cooling the gas containing chamber with the heat or cold source to aspirate a first volume of liquid into the device; and heating the gas containing chamber to dispense a second volume of liquid out of the device. In a preferred embodiment, the metering device is a used in a diagnostic analyzer for determining the presence of one or more analytes in a sample. | 04-09-2009 |
20090233310 | PARTICLE AGGLUTINATION IN A TIP - An apparatus and a related method for performing particle agglutination reactions in a single, disposable probe tip are disclosed. The probe tip includes a sample cavity for sample acquisition, at least one flanking cavity for the capture of particles by centrifugation or other means, a transition zone for the mixing of the sample with reagents for agglutination and a detection zone for the optical detection of particle agglutination. A mechanism may be attached to the probe tip for the controlled movement of fluids through the internal volume of the probe tip. The probe tip is particularly useful for the automation of high-throughput agglutination-type assays. | 09-17-2009 |
20100221757 | PATIENT SAMPLE CLASSIFICATION BASED UPON LOW ANGLE LIGHT SCATTERING - An apparatus for classifying a liquid patient sample includes at least one sample container having a quantity of a sample that is aggressively acted upon so as to create a flow field. A measurement mechanism includes at least one low angle light emitter aligned with a measurement window of the at leas tone sample container and a detector oppositely disposed relative to the measurement window. Measurement of the scattered light detects particle characteristics of a moving flow field from the sample to determine, for example, the amount of agglutination of the sample so as to perform blood typing or other classifications without spatial separation. | 09-02-2010 |
20110070600 | PARTICLE AGGLUTINATION IN A TIP - An apparatus and a related method for performing particle agglutination reactions in at least one disposable probe tip are disclosed. The at least one probe tip includes a sample cavity for sample acquisition, at least one flanking cavity for the capture of particles by centrifugation or other means, a transition zone for the mixing of the sample with reagents for agglutination and a detection zone for the optical detection of particle agglutination. A mechanism may be attached to the probe tip for the controlled movement of fluids through the internal volume of the probe tip. The probe tip is particularly useful for the automation of high-throughput agglutination-type assays. | 03-24-2011 |
20110252872 | METHOD FOR ESTIMATING VISCOSITY - A method for estimating the viscosity of a liquid in an aspirating or dispensing probe, includes: measuring a reference pressure which is the pressure inside a metering tip when no dispense or aspirate is occurring (P | 10-20-2011 |
20120040446 | PARTICLE AGGLUTINATION IN A TIP - An apparatus and a related method for performing particle agglutination reactions in at least one disposable probe tip are disclosed. The at least one probe tip includes a sample cavity for sample acquisition, at least one flanking cavity for the capture of particles by centrifugation or other means, a transition zone for the mixing of the sample with reagents for agglutination and a detection zone for the optical detection of particle agglutination. A mechanism may be attached to the probe tip for the controlled movement of fluids through the internal volume of the probe tip. The probe tip is particularly useful for the automation of high-throughput agglutination-type assays. | 02-16-2012 |
20120258479 | Assay Device Having Rhombus-Shaped Projections - An assay device includes: a liquid sample receiving zone; a capture zone in fluid communication with the sample receiving zone having capture elements bound thereto, the capture zone having a substrate and projections which extend substantially vertically from the substrate, the projections having a rhombus-shaped cross-section and the projections arranged on the substrate with the corners of the projections facing upstream in a direction toward the sample receiving zone. The projections have a height, cross-section and a distance between one another that defines a capillary space between the projections capable of generating capillary flow parallel to the substrate surface; and a sink in fluid communication with the capture zone having a capacity to receive liquid sample flowing from the capture zone. The sample receiving zone, the capture zone and the sink define a fluid flow path. Preferably, the rhombus-shaped cross-section is a square or a diamond. | 10-11-2012 |
20130189672 | Assay Device Having Multiple Reagent Cells - An assay device includes: a liquid sample zone; a reagent zone downstream and in fluid communication with the sample zone. The reagent zone includes at least two reagent cells containing a reagent material and arranged in the reagent zone such that each reagent cell experiences substantially the same flow conditions of sample from the sample zone. The reagent cells divide the sample flow from the sample zone into multiple flow streams. Also includes are: one or more flow control elements disposed downstream from the reagent zone which combine the multiple flow streams into fewer flow streams; a detection zone in fluid communication with the reagent zone; and a wicking zone in fluid communication with the detection zone having a capacity to receive liquid sample flowing from the detection zone. The sample addition zone, the detection zone and the wicking zone define a fluid flow path. | 07-25-2013 |
20130189673 | Assay Device Having Controllable Sample Size - Disclosed is an assay device which comprises a liquid sample addition zone, a reagent zone, a detection zone, and a wicking zone, all defining a fluid flow path. The device further comprises a reagent addition zone along and in fluid communication with the fluid flow path downstream of the sample addition zone and upstream of the detection zone. An interrupting wash is added at this reagent addition zone in accordance with the method of the subject invention to control sample volume. The interrupting wash fluid is added at a predetermined fill volume on the chip device and also serves to wash the detection channel and fill the remaining chip volume. | 07-25-2013 |
20130189796 | Assay Device Having Uniform Flow Around Corners - An assay device includes: a liquid sample zone; a reagent zone downstream and in fluid communication with the sample zone containing a reagent material; a detection zone in fluid communication with the reagent zone having capture elements bound thereto; and a wicking zone in fluid communication with the capture zone having a capacity to receive liquid sample flowing from the detection zone. The sample receiving zone, the reagent zone, the detection zone and the wicking zone define a fluid flow path and at least a part of the fluid flow path has a substrate and projections which extend substantially vertically from the substrate, wherein the projections have a height, cross-section and a distance between one another that defines a space between the projections capable of generating capillary flow parallel to the substrate surface. In addition, the fluid flow path having projections includes a corner section which changes the direction of the flow path. The projections in or around the corner section are modified to maintain the configuration of the flow front of the sample flowing through the flow path after the corner is substantially the same configuration as before the corner. | 07-25-2013 |
20130210036 | Controlling Fluid Flow Through An Assay Device - An assay device includes: a detection zone which includes a first set of projections which are capable of generating capillary flow. A wicking zone (WZ) has a capacity to receive liquid sample flowing from the detection zone and includes a second set of projections which are capable of generating capillary flow. The WZ is rectangular in shape and the longer side of the rectangle extends in the direction of flow to thereby reduce the pressure gradient in the assay device which increases the total flow time of liquid sample compared to a WZ having equal length sides and same volume. At least a portion of the second set of projections have at least one dimension selected from a diameter, a center-to-center spacing, or a gap between projections that is different from the first set of projections, and is selected to increase the total flow time of the sample. | 08-15-2013 |
20130330713 | LATERAL FLOW ASSAY DEVICES FOR USE IN CLINICAL DIAGNOSTIC APPARATUS AND CONFIGURATION OF CLINICAL DIAGNOSTIC APPARATUS FOR SAME - A lateral flow device for use in a mainframe or point-of-care clinical analyzer, in which the lateral flow device includes a planar support having at least one sample addition area and at least one reaction area disposed thereon. The sample addition area and reaction area are fluidly interconnected to one another and form at least one lateral fluid flow path. The lateral flow device is sized for retention within a storage cartridge of the analyzer defined by a hollow interior and having a plurality of lateral flow assay devices retained in stacked relation therein. | 12-12-2013 |
20140134653 | Calibrating Assays Using Reaction Time - A method for performing an assay on a liquid sample for the detection of one or more analytes of interest in an assay device having a flow path which includes a sample zone and detection zone thereon includes: dispensing the sample onto the sample zone; combining the sample and a reagent, wherein the sample and reagent may be combined prior to addition of the sample to the sample zone or on the assay device, flowing the combined sample/reagent by capillary action into and through the detection zone having capture elements bound thereto, wherein a signal at least partially representative of the presence or concentration of analyte(s) is produced and detected; determining a reaction time or reaction volume; and determining the concentration of the analyte by using both the detected signal and the reaction time or reaction volume. | 05-15-2014 |
20140141527 | QUALITY/PROCESS CONTROL OF A LATERAL FLOW ASSAY DEVICE BASED ON FLOW MONITORING - A method for providing quality control on a lateral flow assay device or for triggering a process-related step, the device including a substrate having at least one sample receiving area, at least one reagent zone downstream and in fluid communication with the at least one sample receiving area, at least one detection zone downstream and in fluid communication with the at least one reagent zone and at least one wicking zone downstream of the at least one detection zone, each fluidly interconnected therewith along at least one fluid flow path. The detection material provided in the at least one reagent zone produces a detectable signal that can be tracked and monitored prior to the completion of at least one test being performed on the lateral flow assay device. | 05-22-2014 |
20140206098 | Low Volume Assay Device Having Increased Sensitivity - An assay device includes: a liquid sample zone; a reagent zone downstream and in fluid communication with the sample addition zone containing a reagent material; a detection zone in fluid communication with the reagent zone. The detection zone has a substrate and projections which extend substantially vertically from the substrate, wherein the projections have a height, cross-section and a distance between one another that defines a capillary space between the projections capable of generating capillary flow parallel to the substrate surface. The device is capable of creating a reagent plume in the detection zone that includes liquid sample and dissolved reagent, where the width of the reagent plume extends substantially across the width of the detection zone, The device further includes a wicking zone in fluid communication with the detection zone having a capacity to receive liquid sample flowing from the detection zone. | 07-24-2014 |
20140272941 | ROTATABLE FLUID SAMPLE COLLECTION DEVICE - A sample collection device for a fluid sample includes: a body including a capillary channel having a first end and a second end, wherein the first end is adapted to draw the fluid into the channel by capillary action; an air vent located in the vicinity of the second end and in fluid communication with the capillary channel; a barrier positioned within the capillary channel to prevent flow of the fluid by capillary action thereacross; and features on opposing sides of the body to form an axis of rotation, which is substantially perpendicular to the overall direction of the capillary channel from the first end to the second end. In a preferred embodiment, the sample collection device is adapted to rotate about the axis of rotation within a cartridge having a sample manipulation device to bring the first end into position with the sample manipulation device. | 09-18-2014 |
20140275866 | ROTATABLE DISK-SHAPED FLUID SAMPLE COLLECTION DEVICE - A sample collection device for a fluid includes: a substantially disk-shaped body having a periphery; a capillary channel extending through the body and bounded by the periphery, having a first end and a second end, wherein the first end is adapted to draw the fluid into the channel by capillary action; a sample collection well located in the vicinity of the second end and in fluid communication with the capillary channel; and an axis of rotation extending through the center of the disk and which is substantially perpendicular to the major surface of the disk-shaped body. In a preferred embodiment, the sample collection device is adapted to rotate about the axis of rotation within a cartridge having a housing comprising an air vent in fluid communication with the capillary channel when the disk is rotated in a first position. | 09-18-2014 |
20150153337 | Assay Device Having Uniform Flow Around Corners - An assay device includes: a liquid sample zone; a reagent zone downstream and in fluid communication with the sample zone containing a reagent material; a detection zone in fluid communication with the reagent zone having capture elements bound thereto; and a wicking zone in fluid communication with the capture zone having a capacity to receive liquid sample flowing from the detection zone. The sample receiving zone, the reagent zone, the detection zone and the wicking zone define a fluid flow path and at least a part of the fluid flow path has a substrate and projections which extend substantially vertically from the substrate, wherein the projections have a height, cross-section and a distance between one another that defines a space between the projections capable of generating capillary flow parallel to the substrate surface. In addition, the fluid flow path having projections includes a corner section which changes the direction of the flow path. The projections in or around the corner section are modified to maintain the configuration of the flow front of the sample flowing through the flow path after the corner is substantially the same configuration as before the corner. | 06-04-2015 |
20150153338 | Low Volume Assay Device Having Increased Sensitivity - An assay device includes: a liquid sample zone; a reagent zone downstream and in fluid communication with the sample addition zone containing a reagent material; a detection zone in fluid communication with the reagent zone. The detection zone has a substrate and projections which extend substantially vertically from the substrate, wherein the projections have a height, cross-section and a distance between one another that defines a capillary space between the projections capable of generating capillary flow parallel to the substrate surface. The device is capable of creating a reagent plume in the detection zone that includes liquid sample and dissolved reagent, where the width of the reagent plume extends substantially across the width of the detection zone, The device further includes a wicking zone in fluid communication with the detection zone having a capacity to receive liquid sample flowing from the detection zone. | 06-04-2015 |
20160038936 | LATERAL-FLOW ASSAY DEVICE HAVING FLOW CONSTRICTIONS - A lateral-flow assay device includes a substrate having a sample addition zone and a wash addition zone downstream thereof along a fluid flow path through which a sample flows. The fluid flow path is configured to receive a wash fluid in the wash addition zone. A hydrophilic surface is arranged in the wash addition zone. Flow constriction(s) are spaced apart from the fluid flow path and arranged to define, with the hydrophilic surface, a reservoir configured to retain the wash fluid by formation of a meniscus between the hydrophilic surface and the flow constriction(s). The fluid flow path draws the wash fluid from the reservoir by capillary pressure. Apparatus for analyzing a fluidic sample and methods of displacing a fluidic sample in a fluid flow path of an assay device are also described. | 02-11-2016 |
20160038937 | LATERAL-FLOW ASSAY DEVICE WITH FILTRATION FLOW CONTROL - A lateral-flow assay device includes a substrate with a sample addition zone and a fluid flow path. A cover supports a filter having a portion contacting the substrate to create a contact area that at least partly overlaps the sample addition zone. Another portion extends from the contact portion to the supported periphery of the filter to define with the substrate a reservoir configured to retain the filtrate by capillary pressure between the substrate and the extending portion. The reservoir volume is based on an acute angle formed between the substrate and the extending portion of the filter and on a fluid meniscus of the filtrate. The filter and sample addition zone are configured to provide capillary pressure drawing the filtrate from the reservoir to the sample addition zone. Methods for controlling flow characteristics in a lateral-flow assay device are also described. | 02-11-2016 |
20160041163 | LATERAL FLOW ASSAY DEVICE - A lateral flow assay device includes a substrate having a top surface, as well as a sample receiving area disposed upon the top surface. At least one fluid flow path extends along the substrate from the sample receiving area, wherein the sample receiving area can be placed in contact with a peripheral reservoir formed at a sample addition area to draw sample therefrom in a controlled manner. The device can further include a reagent area that is designed to promote uniform dissolution of a deposited detection material by a sample moved through the device along the fluid flow path as well, as a flow channel configure to promote mixing of sample and reagent and an absorbing or wicking zone configured to affect various flow characteristics. | 02-11-2016 |