Zhang, Edison
Fei Zhang, Edison, NJ US
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20090124601 | Tartaric Acid Salts of a Dipeptidyl Peptidase-IV Inhibitor - Tartaric acid salts of (3R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl) butanoyl]hexahydro-3-(2,2,2-trifluoroethyl)-2H-1,4-diazepin-2-one are potent inhibitors of dipeptidyl peptidase-IV and are useful for the prevention and/or treatment of non-insulin dependent diabetes mellitus, also referred to as Type 2 diabetes. The invention also relates to crystalline anhydrate forms of the tartaric acid salts as well as a process for their preparation, pharmaceutical compositions containing these novel forms and methods of use for the treatment of Type 2 diabetes. | 05-14-2009 |
Fengqi Zhang, Edison, NJ US
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20090062280 | Ophthalmic Compositions for Treating Ocular Hypertension - This invention relates to the use of potent potassium channel blockers or a formulation thereof in the treatment of glaucoma and other conditions which leads to elevated intraocular pressure in the eye of a patient. This invention also relates to the use of such compounds to provide a neuroprotective effect to the eye of mammalian species, particularly humans. | 03-05-2009 |
20090281154 | Ophthalmic Compositions for Treating Ocular Hypertension - This invention relates to the use of potent potassium channel blockers or a formulation thereof in the treatment of glaucoma and other conditions which leads to elevated intraoccular pressure in the eye of a patient. This invention also relates to the use of such compounds to provide a neuroprotective effect to the eye of mammalian species, particularly humans. | 11-12-2009 |
20110172256 | GLUCAGON RECEPTOR ANTAGONIST COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE - Glucagon receptor antagonist compounds are disclosed. The compounds are useful for treating type 2 diabetes and related conditions. Pharmaceutical compositions and methods of treatment are also included. | 07-14-2011 |
20110281795 | GLUCAGON RECEPTOR ANTAGONIST COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE - Glucagon receptor antagonist compounds are disclosed. The compounds are useful for treating type 2 diabetes and related conditions. Pharmaceutical compositions and methods of treatment are also included. | 11-17-2011 |
20140357632 | BENZOPIPERAZINE DERIVATIVES AS CETP INHIBITORS - Compounds having the structure of Formula Ia, including pharmaceutically acceptable salts of the compounds, are CETP inhibitors and may be useful for raising HDL-cholesterol, reducing LDL-cholesterol, and for treating or preventing atherosclerosis. | 12-04-2014 |
20150018399 | GLUCAGON RECEPTOR ANTAGONIST COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE - Glucagon receptor antagonist compounds are disclosed. The compounds are useful for treating type 2 diabetes and related conditions. Pharmaceutical compositions and methods of treatment are also included. | 01-15-2015 |
20150111866 | CYCLIC AMINE SUBSTITUTED HETEROCYCLIC CETP INHIBITORS - Compounds having the structure of Formula I, including pharmaceutically acceptable salts of the compounds, are CETP inhibitors and may be useful for raising HDL-cholesterol and reducing LDL-cholesterol in human patients and for treating or preventing atherosclerosis. | 04-23-2015 |
Fengqi Abe Zhang, Edison, NJ US
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20080242597 | Antibiotic compounds - The present invention relates to novel thiazolyl peptide antibiotics capable of treating serious bacterial infections in mammals, and particularly, in humans. Some of the analogs can also be versatile intermediates for the preparation of new derivatives with useful antibacterial activity. | 10-02-2008 |
Fucheng Zhang, Edison, NJ US
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20090312576 | PROCESS AND INTERMEDIATES FOR THE PREPARATION OF 3-(AMINO)-3-CYCLOBUTYLMETHYL-2-HYDROXY-PROPIONAMIDE OR SALTS THEREOF - In one embodiment, the present application relates to a process of making a compound of formula I: | 12-17-2009 |
20140031549 | Process and Intermediates for the Synthesis of 8-[-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one Compounds - This application discloses a novel process to synthesize 8-[{1-(3,5-Bis-(trifluoromethyl)phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one compounds, which may be used, for example, as NK-1 inhibitor compounds in pharmaceutical preparations, intermediates useful in said process, and processes for preparing said intermediates; also disclosed is a process for removal of metals from N-heterocyclic carbine metal complexes. | 01-30-2014 |
Henry Zheng Zhang, Edison, NJ US
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20160055160 | Generating Cards in Response to User Actions on Online Social Networks - In one embodiment, a method includes accessing a social graph by a social-networking system. The social graph includes a plurality of nodes and a plurality of edges connecting the nodes. The social-networking system may receive a trigger action from a first user. In response to the trigger action, the social-networking system may generate reaction-cards based at least in part on the trigger action where each reaction-card is associated with a structured query referencing nodes and edges of the social graph. The social-networking system may calculate a reaction-card score for each reaction-card, where the reaction-card score is based on a relevance of the structured query associated with the reaction-card to the trigger action and user-engagement factors. The social-networking system may then send each reaction-card having a reaction-card score greater than a threshold reaction-card score to the first user for display on a page currently accessed by the first user. | 02-25-2016 |
Junjie Zhang, Edison, NJ US
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20130071374 | RNA Interferases and Methods of Use Thereof - The present invention is directed to the discovery of a novel family of enzymes designated herein as mRNA interferases that exhibit endoribonuclease activity. The novel finding of the present inventors, therefore, presents new applications for which mRNA interferase nucleic and amino acid sequences, and compositions thereof may be used to advantage. The invention also encompasses screening methods to identify compounds/agents capable of modulating mRNA interferase activity and methods for using such compounds/agents. Also provided is a kit comprising mRNA interferase nucleic and/or amino acid sequences, mRNA interferase activity compatible buffers, and instruction materials. | 03-21-2013 |
20140234258 | RNA Interferases and Methods of Use Thereof - The present invention is directed to the discovery of a novel family of enzymes designated herein as mRNA interferases that exhibit endoribonuclease activity. The novel finding of the present inventors, therefore, presents new applications for which mRNA interferase nucleic and amino acid sequences, and compositions thereof may be used to advantage. The invention also encompasses screening methods to identify compounds/agents capable of modulating mRNA interferase activity and methods for using such compounds/agents. Also provided is a kit comprising mRNA interferase nucleic and/or amino acid sequences, mRNA interferase activity compatible buffers, and instruction materials. | 08-21-2014 |
Linqi Zhang, Edison, NJ US
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20100021427 | Use of Antiviral Peptides For Treatment of Infections Caused by Drug-Resistant HIV - The present invention provides methods of treating drug-resistant HIV infections especially of HIV strains that are resistant to infusion inhibitors, such as T20. | 01-28-2010 |
Rumin Zhang, Edison, NJ US
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20100119483 | PEPTIDE VIRAL ENTRY INHIBITORS - The present invention provides, inter alia, peptide compositions and methods for treating and preventing Flaviviridae virus (e.g., HCV) infections. | 05-13-2010 |
20100136620 | SOLUBLE, STABLE FORM OF HDM2, CRYSTALLINE FORMS THEREOF AND METHODS OF USE THEREOF - The present invention discloses modified Hdm2 proteins that are soluble. In addition, the present invention discloses nucleic acids that encode the modified Hdm2 proteins of the present invention. The invention also provides crystals of modified Hdm2 proteins that are suitable for X-ray crystallization analysis. The present invention also discloses methods of using the modified Hdm2 proteins and crystals thereof to identify, select and/or design compounds that may be used as anticancer agents. The present invention further discloses compounds that bind to modified Hdm2 proteins in protein-ligand complexes. | 06-03-2010 |
20100267150 | HDM2 POLYPEPTIDES - The present invention relates to HDM2 polypeptides and mutants thereof which are complexed with various compounds, e.g., HDM2 inhibitors. | 10-21-2010 |
Xiaoping Zhang, Edison, NJ US
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20120183578 | POLYETHYLENE GLYCOL-BASED DENDRONS - The instant invention relates to polyethylene glycol-based dendrons, otherwise known as PEGtide dendrons, compositions thereof and methods of use. | 07-19-2012 |
20120183621 | SYNERGISTIC COMBINATIONS TO REDUCE PARTICLE DOSE FOR TARGETED TREATMENT OF CANCER AND ITS METASTASES - Non-Small Cell Lung Carcinomas (NSCLCs) are treated with Gel Micro-Particles (GMPs) that passively accumulate in the lungs and contain Nano-Particles (NPs) combining one or more therapeutic agents that are cytotoxic to the NSCLC with one or more NSCLC active targeting ligands, as well as one or more other optional agents that increase cellular uptake, enhance the pro-apoptotic effect of the chemotherapeutic agent(s), and the like. NPs targeting other cancer cells are also disclosed, as well as NP-containing GMPs that reduce the occurrence of tumor metastasis. | 07-19-2012 |
Xun Zhang, Edison, NJ US
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20130040820 | FAULT CURRENT LIMITER INCORPORATING A SUPERCONDUCTING ARTICLE AND A HEAT SINK - A fault current limiting (FCL) article comprising a superconducting tape segment comprising a substrate, a buffer layer overlying the substrate, a high temperature superconducting (HTS) layer overlying the buffer layer, and a heat sink overlying the HTS layer, where the heat sink is comprised of a non-metal material, a thermal conductivity of not less than about 0.1 W/m-K at 20° C., an electrical resistivity of not less than about 1E-5 Ω-m at 20° C., and a shunting circuit electrically connected to the superconducting tape segment. | 02-14-2013 |
Yunlei Zhang, Edison, NJ US
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20100174588 | SYSTEM AND METHOD FOR BANKING MARKET ANALYSIS - System and method of estimating a wallet share for one or more advisors for investment banking deals involving equity-related products that occurred during an evaluation time period. Method may comprising determining a fee estimate for the one or more advisors for the deals involving equity-related products during the evaluation time period, wherein the fee estimate for the one or more advisors for each deal is determined based on one or more look-up tables specific to the type of equity-related product and the geographic region for the deal, and wherein the one or more look-up tables indicate a fee estimate for the one or more advisors based on the deal size, the number of advisors, and the role of the one or more advisors. Method may also comprise determining a wallet share for the one or more advisors over the evaluation time period based on an aggregation of the fee estimates for the one or more advisors during the evaluation time period. | 07-08-2010 |
Zhioyng Zhang, Edison, NJ US
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20140113306 | DIAGNOSTIC AND SCREENING METHODS FOR INFLAMMATION - This invention is directed to methods, kits and compositions for the diagnosis and treatment of conditions associated with sub-clinical inflammatory conditions such as diabetes mellitus. | 04-24-2014 |