Patent application number | Description | Published |
20090081645 | METHOD OF ASSUMING DRUG SENSITIVITY TO CDK4 INHIBITOR - It is intended to provide a gene for assuming drug sensitivity, which is to be used for assuming the drug sensitivity to a CDK4 inhibitor based on the expression amount in a test tissue or a test cell, selected from the group consisting of p16 gene, p18 gene and p27 gene. It is also intended to provide a method of assuming the drug sensitivity to a CDK4 inhibitor by using the expression amount of the above gene in a test tissue or a test cell as an indication. | 03-26-2009 |
20100184236 | GUANOSINE TRIPHOSPHATE (GTP)-BINDING PROTEIN-COUPLED RECEPTOR PROTEIN, BG37 - The present inventors conducted a similarity search of the amino acid sequence of known G protein-coupled receptor proteins in GenBank, and obtained a novel human GPCR gene “BG37”, cDNA containing the ORF of the gene was cloned and its nucleotide sequence was determined. Moreover, novel GPCR “BG37” genes from mouse and rat were isolated. Use of the novel GPCR of the present invention enables screening of ligands, compounds inhibiting the binding to a ligand, and candidate compounds of pharmaceuticals which can regulate signal transduction from the “BG37” receptor. | 07-22-2010 |
20120157342 | PREDICTIVE BIOMARKERS USEFUL FOR CANCER THERAPY MEDIATED BY A WEE1 INHIBITOR - The present invention provides the identification of biomarker gene sets whose expression levels are useful for predicting a patient's response to a therapeutically effective dose of a Wee1 inhibitor as well the ability to predict said response prior to dosing with the Wee1 inhibitor. Additional uses are also disclosed in the specification. | 06-21-2012 |
Patent application number | Description | Published |
20100244389 | LIP TYPE SEAL - To facilitate recycling and prevent rotation of constituent parts, a lip type seal has a first lip seal member constructed from a rubber-like elastic material, a metal-made retaining ring held at the first lip seal member without bonding, and a resin-made second lip seal member and a backup ring which are held at the retaining ring by caulking. The first lip seal member has a tubular portion, a radial portion, a seal lip, and a collar portion. The retaining ring has a cylinder portion, a first flange portion, and a second flange portion, and the second lip seal member and the backup ring are held between the first and second flange portions by caulking. A convex portion is provided at a position in the circumferential direction of the first flange portion, and the convex portion engages with the second lip seal member to prevent rotation of the second lip seal member. | 09-30-2010 |
20110215536 | LIP TYPE SEAL - For better assembling characteristic and sealing performance with secured circularity and coaxiality of a seal lip, a lip type seal installed to an inner periphery of a shaft hole of a housing in slidable contact with a peripheral surface of a shaft for inhibiting a sealed fluid in the machine from leaking to an atmospheric air side, has a cartridge fitted to an inner periphery of the shaft hole, a first lip seal member made of a rubber-like elastic material and fitted in a non-bonding manner to the cartridge, a case fitted in a non-bonding manner to the first lip seal member, a second lip seal member made of a resin and a backup ring supporting the second lip seal member which are retained by caulking to the case, and an adapter fitted to the cartridge at a sealed fluid side of the first lip seal member. | 09-08-2011 |
20130228978 | SEALING DEVICE AND SEALING STRUCTURE - A sealing device and a sealing structure in which sliding ability is stabilized are provided. A lip tip of a first seal lip ( | 09-05-2013 |
Patent application number | Description | Published |
20090098237 | THERMOPLASTIC RESIN FOAM AND PRODUCTION PROCESS THEREOF - Disclosed is a die plate for a die block having a coat-hanger-shaped flow path for extruding a molten foamable thermoplastic resin in a form of a sheet. The die plate is for arrangement on a downstream side of the coat-hanger-shaped flow path to make a flow rate of the molten foamable thermoplastic resin uniform in a width direction. The die plate is provided with a multiplicity of delivery apertures. In the delivery apertures, the delivery apertures in opposite side regions have a diameter greater than a diameter which the delivery apertures in a center region have. A die unit composed of a die block, which has a multiple bifurcated manifold terminating in plural coat-hanger-shaped flow paths at downward ends thereof, and a like plural number of similar die plates as described above; a process for producing a wide thermoplastic resin foam by using the die unit; and the wide thermoplastic resin foam are also disclosed. | 04-16-2009 |
20100273904 | PROCESS FOR PRODUCING POLYPROPYLENE RESIN FOAM - Disclosed is a process for producing a polypropylene-based resin foam by subjecting a linear polypropylene-based resin, which has a melt tension at 230° C. of from 5 to 30 g and satisfies the below-described formula (1) in which MFR stands for a melt flow rate of the linear polypropylene-based resin at 230° C. and MT stands for the melt tension at 230° C., to melt extrusion through an extruder while injecting carbon dioxide into the resulting molten resin to foam the molten resin. The process includes subjecting the extruder to temperature control such that the extruder has a temperature of from 200 to 240° C. at a position of a cylinder barrel thereof, where the carbon dioxide is to be introduced, and the cylinder barrel has a temperature of from 175 to 190° C. at a position before the foaming; and then discharging the molten resin into atmospheric pressure with a discharge rate of the molten resin per opening area of a die being controlled to give a resin pressure of from 5 to 20 MPa at a position immediately proximal to an opening of the die, thereby foaming the molten resin. The process of the present invention can provide a polypropylene-based resin foam having a high expansion ratio, uniformly dispersed foam cells and a good surface appearance. | 10-28-2010 |
20100324162 | FOAM BOARD OF POLYOLEFIN RESIN AND METHOD FOR ITS PRODUCTION - To provide a foam board of a polyolefin resin which has an excellent heat insulating property and sound absorption property, of which a product can be material-recycled and which can continuously be produced at a low cost. | 12-23-2010 |
20110021650 | EXTRUDED POLYPROPYLENE RESIN FOAM AND PROCESS FOR PRODUCING THE SAME - An extruded polypropylene type resin foam having a high expansion ratio of at least 15 times and a closed cell ratio of at least 70% and excellent in the heat insulation property, and its production process, are provided. | 01-27-2011 |
20120091612 | THERMOPLASTIC RESIN FOAM AND PRODUCTION PROCESS THEREOF - A die plate for a die block can have a coat-hanger-shaped flow path for extruding a molten foamable thermoplastic resin in a form of a sheet. The die plate can be on a downstream side of the coat-hanger-shaped flow path to make a flow rate of the molten foamable thermoplastic resin uniform in a width direction. The die plate can have a multiplicity of delivery apertures. The delivery apertures in opposite side regions can have a diameter greater than a diameter which the delivery apertures in a center region have. A die unit can include a die block, which has a multiple bifurcated manifold terminating in plural coat-hanger-shaped flow paths at downward ends thereof, and a like plural number of similar die plates as described above. A process for producing a wide thermoplastic resin foam can use the die unit. | 04-19-2012 |