Patent application number | Description | Published |
20080199425 | Sensitization of Immune System Against Haptenized Melanoma Antigens - The invention is based on the observation that certain phenols, monophenols or benzenediols, can be metabolized into reactive quinones, in particular ortho-quinones and related reactive intermediates, which is brought about by oxidation of monophenols and benzenediols by proteins exhibiting tyrosinase activity, such as human tyrosinase and the related proteins TRP1 and TRP2. Although the substances and the produced reactive intermediates are toxic and can induce cell death, it is more relevant according to this invention that they function as haptens that become covalently bound to the tyrosinase enzymes, in particular to histidine moieties, in or near the catalytic site of proteins exhibiting tyrosinase activity, such as tyrosinase, TRP1 and TRP2. An immune response is then to be mounted against these haptenized auto-antigens, in order to treat melanocytic malignancies, in particular melanomas. This is brought about by topical administration of the phenol compounds that can function as tyrosinase substrate analogues. The invention hence provides medicaments for and methods of treating melanomas. | 08-21-2008 |
20120315304 | SENSITIZATION OF IMMUNE SYSTEM AGAINST HAPTENIZED MELANOMA ANTIGENS - The metabolization of certain phenols, monophenols or benzenediols into reactive quinone compounds, in particular ortho-quinones and related reactive intermediates, which is brought about by oxidation of monophenols and benzenediols by proteins exhibiting tyrosinase activity, such as human tyrosinase and the related proteins TRP1 and TRP2. The compounds function as haptens that become covalently bound to the tyrosinase enzymes, in particular to histidine moieties, in or near the catalytic site of proteins exhibiting tyrosinase activity, such as tyrosinase, TRP1 and TRP2. An immune response is then to be mounted against these haptenized auto-antigens to treat malignancies. | 12-13-2012 |
Patent application number | Description | Published |
20160108573 | METHOD FOR PRODUCING TEXTILE PRODUCTS, PRODUCTS OBTAINABLE THEREFROM AND METHOD TO RECLAIM THE PRODUCTS - The present invention discloses a method for manufacturing an optionally laminated textile product, the method comprising the steps of: a) providing a first sheet with yarns fastened thereto where the first sheet has a first surface and a second surface and the yarns extend from the first surface of the first sheet, b) heating the second surface of the first sheet thereby at least partly melting the yarns fastened to the first sheet to bond the yarns to the first sheet; c) exposing the second surface of the first sheet to pressure; d) optionally imparting a mechanical force on the molten fraction of the yarns in a direction parallel to the surface of the first sheet; e) applying hot melt adhesive to the second surface of the first sheet; and f)optionally applying a dimensionally stable second sheet to the second surface of the first sheet; with the proviso that where the optional step (f) is absent then step (d) is not optional. | 04-21-2016 |
20160108578 | METHOD FOR PRODUCING TEXTILE PRODUCTS, PRODUCTS OBTAINABLE THEREFROM AND METHOD TO RECLAIM THE PRODUCTS - The present invention pertains to a method for manufacturing a laminated textile product comprising providing a first intermediate product comprising a primary backing having a front surface and a back surface, and yarns stitched into the primary backing, the yarns extending from the front surface of the backing material, feeding the intermediate product along a body having a heated surface, the back surface being pressed against the said heated surface, to at least partly melt the yarns present in the intermediate product to bond the yarns to the backing, wherein the part of the back surface that is pressed against the heated surface has a relative speed with respect to the heated surface, so as to provide a second intermediate product having a calendered back surface, providing a dimensionally stable carrier sheet or secondary backing, and connecting the second intermediate product to the carrier sheet by providing a hot melt adhesive between the calendered surface and the sheet, and pressing the sheet to the second intermediate product to form the textile product. | 04-21-2016 |
Patent application number | Description | Published |
20080216322 | Cartridge for an Appliance for Personal Care and an Appliance Comprising Such a Cartridge - A cartridge for an appliance for personal care, such as skin, dental or hair treatment includes a main body ( | 09-11-2008 |
20090063775 | INSTRUMENT, A SYSTEM AND A CONTAINER FOR PROVISIONING A DEVICE FOR PERSONAL CARE TREATMENT, AND A DEVICE FOR PERSONAL CARE TREATMENT WITH SUCH A CONTAINER - The present invention provides a system and a method for a cache partitioning technique for application tasks based on the scheduling information in multiprocessors. Cache partitioning is performed dynamically based on the information of the pattern of task scheduling provided by the task scheduler ( | 03-05-2009 |
20100011589 | ROTARY SHAVERS, WITH IMPROVED DRIVE AND SUPPORT STRUCTURE FOR THE SHAVING HEADS - The invention relates to a shaver ( | 01-21-2010 |
20100018058 | SHAVING APPARATUS - A shaving apparatus has at least one cutting unit ( | 01-28-2010 |
20110167641 | SHAVING APPARATUS - A shaving apparatus has at least one cutting unit ( | 07-14-2011 |
20120005898 | APPLIANCE FOR PERSONAL CARE WITH AUTOMATIC FLUID DISPENSER - An appliance for personal care, such as skin, dental or hair treatment, comprising a dispensing structure ( | 01-12-2012 |
20130008562 | INSTRUMENT, A SYSTEM AND A CONTAINER FOR PROVISIONING A DEVICE FOR PERSONAL CARE TREATMENT, AND A DEVICE FOR PERSONAL CARE TREATMENT WITH SUCH A CONTAINER - An instrument for filling a substance supply container of a device for personal care treatment has a filling needle having a proximal end connected or connectable to a storage reservoir and a distal end, a substance transport conduit extending from the proximal end to at least one outlet provided in a radially facing surface portion closely adjacent the distal end of the filling needle. A sleeve is arranged around the filling needle and is movable between a first position closing off the at least one outlet and a second position proximally away from the first position and the at least one outlet. A system including such an instrument, a container for cooperation with such an instrument and for provisioning a device for personal care treatment as well as a device for personal care treatment including such a container are described. | 01-10-2013 |
20140047717 | SHAVING APPARATUS - A shaving apparatus has at least one cutting unit ( | 02-20-2014 |
20150013168 | ROTARY SHAVERS, WITH IMPROVED DRIVE AND SUPPORT STRUCTURE FOR THE SHAVING HEADS - The invention relates to a shaver ( | 01-15-2015 |