Levison
Bruce Levison, Twinsburg, OH US
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20130345171 | TREATMENT AND PREVENTION OF CARDIOVASCULAR DISEASE AND THROMBOSIS - Provided herein are compositions for the treatment and/or prevention of cardiovascular disease (CVD), and methods of application and use thereof. In particular, the present invention provides treatment and/or prevention of cardiovascular disease with compounds that inhibit the production of TMA in the gut, such as 3,3-dimethyl-1-butanol (DMB) or other compounds represented by Formula I or as shown in FIGS. | 12-26-2013 |
Bruce S. Levison, Twinsburg, OH US
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20100285517 | TRIMETHYLAMINE COMPOUNDS AS RISK PREDICTORS OF CARDIOVASCULAR DISEASE - Methods of characterizing a test subject's risk of having or developing cardiovascular disease are provided. The methods include using an analytic device to determine levels of choline-related trimethylamine-containing compounds such as trimethylamine N-oxide, choline, or betaine in a biological sample obtained from the subject and comparing the levels of the choline-related trimethylamine-containing compound in the subject's biological sample to a control value. The test subject's risk of having cardiovascular disease is then characterized as higher if the levels of the choline-related trimethylamine-containing compound are higher than the control value. Also provided are methods of identifying a subject at risk of experiencing a complication of atherosclerotic cardiovascular disease, and methods of evaluating the efficacy of a cardiovascular therapeutic agent in a subject with cardiovascular disease using levels of choline-related trimethylamine-containing compounds. | 11-11-2010 |
Bruce S. Levison, Highland Heights, OH US
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20120157397 | TRIMETHYLAMINE-CONTAINING COMPOUNDS FOR DIAGNOSIS AND PREDICTION OF DISEASE - The present invention provides markers and methods for determining whether a subject, particularly a human subject, has or is at risk of developing, a disease such as cardiovascular disease, diabetes mellitus, insulin resistance, metabolic syndrome, NAFLD (Nonalcoholic Fatty Liver Disease) or NASH (Nonalcoholic Steatohepatitis) (e.g., within the ensuing year, two years, and/or three years). The present application also relates to the use of such markers and methods for monitoring the status of such diseases in a subject or the effects of therapeutic agents on subjects with such diseases. | 06-21-2012 |
David Levison, Whitehouse, OH US
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20150194044 | MOBILE, LOCATION-AWARE, SELF-POWERED ALARM AND SIGNAL PROCESSING SYSTEM - A mobile, location-aware, self-powered alarm system is disclosed. The alarm system is powered by a combination of a battery and a solar panel and provides communication between a remote module and law enforcement and a data center. The alarm system is adapted to trigger an alarm to notify the remote module, which can include a central operator, of a theft or attempted theft according to desired parameters so that the local law enforcement can be notified. | 07-09-2015 |
Derek Levison, Edgewater, NJ US
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20090311724 | USE OF ADDITIVES FOR THE REDUCTION OF NON-SPECIFIC BINDING IN ASSAYS - A method for reducing non-specific binding in an assay is provided herein. The method includes (a) providing a reaction mixture, which includes or is suspected to include a first component and a second component capable of binding to each other in a specific binding reaction, and (b) adding non-physiological amounts of at least one additive to the reaction mixture before, during or after binding in a sufficient amount to reduce non-specific binding in the reaction mixture. The method further includes (c) monitoring or measuring the presence and/or concentration of at least one of the first and second components after step (b). | 12-17-2009 |
20090317922 | USE OF ADDITIVES TO LOWER THE RATE OF A BINDING REACTION - A method of lowering the rate of a specific binding reaction in an assay for the detection and/or measurement of an analyte of interest is provided herein. In particular, the method includes providing a fluorescent conjugate of the analyte; a component capable of specifically binding to the analyte and its fluorescent conjugate; and a sample, which includes or is suspected to include the analyte. The method also includes allowing the specific binding component to interact simultaneously or at different times with the fluorescent conjugate of the analyte and the analyte in the sample, thereby forming a detectable complex due to the reaction between the fluorescent conjugate of the analyte and its specific binding component, wherein the reaction is performed in the presence of non-physiological amounts of at least one additive. The method further includes monitoring for the rate of change of the concentration of the detectable complex as a function of the amount of analyte in the sample. | 12-24-2009 |
Derek Levison, Berlin DE
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20110262936 | METHOD OF DETERMINING A CONCENTRATION OF ANALYTES OF INTEREST IN A SAMPLE - A method of determining a concentration of analytes of interest in a sample reaction mixture is disclosed. The method can include measuring intensities of the polarized fluorescence of at least one comparative reaction mixture containing different, known amounts of the analytes of interest, and measuring the intensities of the polarized fluorescence of a sample reaction mixture. The method can also include determining the preliminary concentrations of the analytes of interest in the sample reaction mixture by comparing the measured intensities of the sample reaction mixtures at various time points. The margin of error for the preliminary concentration of the analytes of interest in the sample can be determined at the various time points. Finally, the concentration of the analytes of interest in the sample reaction mixture can be determined by comparing the preliminary concentrations and the respective margin of error at the given time points. | 10-27-2011 |
Jeffrey Alexander Levison, Mesa, AZ US
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20120203128 | RESPIRATORY RATE DETECTION DEVICE, SYSTEM AND METHOD - A respiration rate measurement device comprising a tubular housing configured to be disposed over a nose and mouth on a face of a subject. The tubular housing comprises a proximal end configured to communicate with the nose and mouth of the subject and receive a transient pressure event from the nose and mouth and a distal end that opens to ambient atmosphere. The tubular housing is configured to guide a flow of air, generated from the transient pressure event, between the proximal end and the distal end. The respiration rate measurement device further comprises a sensor disposed within the housing. The sensor is configured to detect a respiration event by monitoring the flow of air within the tubular housing. | 08-09-2012 |
Jerri Levison, Colorado Springs, CO US
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20110087991 | Methods and Apparatus for Reliable Entry and Enhanced Presentation of IPv6 Addresses - A technique for establishing an IPv6 address for a network device involves displaying a prefix field for accessing a list of IPv6 address prefixes, an interface identifier field for accessing a list of interface identifiers, and a fillable address field for entering an IPv6 address. An IPv6 address is constructed in the address field from an IPv6 address prefix selected from the prefix field and an interface identifier selected from the interface identifier field. The IPv6 address can be modified by manually entering characters via a user interface. A technique for displaying IPv6 addresses involves combining a mnemonic, which replaces the digits of the IPv6 address prefix portion of the address, together with the digits of the interface identifier of the IPv6 address. IPv6 addresses not associated with a mnemonic are readily identifiable. | 04-14-2011 |
Lisa Turner Levison, St. George Island, FL US
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20120034314 | Antiseptic Liquid Formulation, A Method for Its Use, and A Method for Preparing the Formulation - An antiseptic formulation capable of providing antimicrobial properties over an extended period of time is disclosed. The formulation includes chelated metal ions and a fixative polymer with the capacity to bond the chelated metal ions to the skin. This fixative polymer, polyquaternium-69 has the ability to bond chelated metal ions, and other types of antimicrobial agents, to the skin for periods of hours or days depending on the conditions in which it is used. An antiseptic liquid formulation can be integrated in a soap product and a spray product. An antiseptic gel formulation is further disclosed. | 02-09-2012 |
Nadav Levison, Tel-Aviv IL
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20120203946 | LIVELOCK PREVENTION MECHANISM IN A RING SHAPED INTERCONNECT UTILIZING ROUND ROBIN SAMPLING - A novel and useful cost effective mechanism for detecting the livelock/starvation of transactions in a ring shaped interconnect that utilizes minimal logic resources. Rather than monitor all transactions concurrently in the ring, the mechanism monitors only a single transaction in the ring. A sampling point is located at a point in the ring which contains a set of N latches. If the monitored transaction is not being starved, it is released and the detection logic moves on the next candidate transaction in round robin fashion. If the monitored transaction passes the sampling point a threshold number of times, it is deemed to be starved and a starvation prevention handling procedure is activated. By traversing the entire ring a single transaction at a time, all starving transactions will eventually be detected with an upper limit on the detection time of O(N | 08-09-2012 |
20130151818 | MICRO ARCHITECTURE FOR INDIRECT ACCESS TO A REGISTER FILE IN A PROCESSOR - A method and system for improving performance and latency of instruction execution within an execution pipeline in a processor. The method includes finding, while decoding an instruction, a pointer register used by the instruction; reading the pointer register; validating a pointer register entry; reading, if the pointer register entry is valid, a register file entry; validating a register file entry; validating, if the register file entry is invalid, a valid register file entry wherein the valid register file entry is in the register file's future file; bypassing, if the valid register file entry is valid, a valid register file value from the register file's future file to the execution pipeline wherein the valid register file value is in the valid register file entry; and executing the instruction using the valid register file value; wherein at least one of the steps is carried out using a computer device. | 06-13-2013 |
Nadav Levison, Herut IL
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20120159082 | Direct Access To Cache Memory - Methods and apparatuses are disclosed for direct access to cache memory. Embodiments include receiving, by a direct access manager that is coupled to a cache controller for a cache memory, a region scope zero command describing a region scope zero operation to be performed on the cache memory; in response to receiving the region scope zero command, generating a direct memory access region scope zero command, the direct memory access region scope zero command having an operation code and an identification of the physical addresses of the cache memory on which the operation is to be performed; sending the direct memory access region scope zero command to the cache controller for the cache memory; and performing, by the cache controller, the direct memory access region scope zero operation in dependence upon the operation code and the identification of the physical addresses of the cache memory. | 06-21-2012 |
Nadav Levison, Moshav Herut IL
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20130138922 | REGISTER MANAGEMENT IN AN EXTENDED PROCESSOR ARCHITECTURE - Systems and methods are disclosed for enhancing the throughput of a processor by minimizing the number of transfers of data associated with data transfer between a register file and a memory stack. The register file used by a processor running an application is partitioned into a number of blocks. A subset of the blocks of the register file is defined in an application binary interface enabling the subset to be pre-allocated and exposed to the application binary interface. Optionally, blocks other than the subset are not exposed to the application binary interface so that the data relating to application function switch or a context switch is not transferred between the unexposed blocks and a memory stack. | 05-30-2013 |
Peter Levison, Hampshire GB
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20080299672 | System And Method For Testing Chromatography Media And Devices - Methods for testing the chromatography type and/or the integrity of a chromatography membrane or monolith, preferably, for testing the chromatography type and integrity of a chromatography device comprising a chromatography membrane or chromatography monolith while the membrane or monolith is sealed in a housing, are disclosed. | 12-04-2008 |
Steven Levison, Cdar Grove, NJ US
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20150361395 | GROWTH MATRICES FOR STEM CELL PROPAGATION IN VITRO AND IN TISSUE REGENERATION - The present invention provides a multifunctional 2-D and 3-D matrix for propagation of stem cells. In particular, a chitosan-based biomaterial scaffold is engineered to promote CNS regeneration from primitive neural precursors by stabilizing a recombinant protein, fibroblast growth factor to preserve the cardinal properties of stem cells. The matrix, is further modified by the addition of either the extracellular matrix protein fibronectin or the small peptide RGD or IKVAV. A method to manufacture an injectable multifunctional microsphere scaffold is also disclosed that is suitable as a vehicle for cell transplantation to repair traumatic brain injuries. | 12-17-2015 |
Stuart Levison, Edgewater, NJ US
Patent application number | Description | Published |
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20090311724 | USE OF ADDITIVES FOR THE REDUCTION OF NON-SPECIFIC BINDING IN ASSAYS - A method for reducing non-specific binding in an assay is provided herein. The method includes (a) providing a reaction mixture, which includes or is suspected to include a first component and a second component capable of binding to each other in a specific binding reaction, and (b) adding non-physiological amounts of at least one additive to the reaction mixture before, during or after binding in a sufficient amount to reduce non-specific binding in the reaction mixture. The method further includes (c) monitoring or measuring the presence and/or concentration of at least one of the first and second components after step (b). | 12-17-2009 |
20090317922 | USE OF ADDITIVES TO LOWER THE RATE OF A BINDING REACTION - A method of lowering the rate of a specific binding reaction in an assay for the detection and/or measurement of an analyte of interest is provided herein. In particular, the method includes providing a fluorescent conjugate of the analyte; a component capable of specifically binding to the analyte and its fluorescent conjugate; and a sample, which includes or is suspected to include the analyte. The method also includes allowing the specific binding component to interact simultaneously or at different times with the fluorescent conjugate of the analyte and the analyte in the sample, thereby forming a detectable complex due to the reaction between the fluorescent conjugate of the analyte and its specific binding component, wherein the reaction is performed in the presence of non-physiological amounts of at least one additive. The method further includes monitoring for the rate of change of the concentration of the detectable complex as a function of the amount of analyte in the sample. | 12-24-2009 |
20110262936 | METHOD OF DETERMINING A CONCENTRATION OF ANALYTES OF INTEREST IN A SAMPLE - A method of determining a concentration of analytes of interest in a sample reaction mixture is disclosed. The method can include measuring intensities of the polarized fluorescence of at least one comparative reaction mixture containing different, known amounts of the analytes of interest, and measuring the intensities of the polarized fluorescence of a sample reaction mixture. The method can also include determining the preliminary concentrations of the analytes of interest in the sample reaction mixture by comparing the measured intensities of the sample reaction mixtures at various time points. The margin of error for the preliminary concentration of the analytes of interest in the sample can be determined at the various time points. Finally, the concentration of the analytes of interest in the sample reaction mixture can be determined by comparing the preliminary concentrations and the respective margin of error at the given time points. | 10-27-2011 |