Van Dun, BE
Jacobus A.j. Van Dun, Beerse BE
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20150072972 | PHTHALAZINE DERIVATIVES AS PARP INHIBITORS - The present invention provides compounds of formula (I), their use as PARP inhibitors as well as pharmaceutical compositions comprising said compounds of formula (I) | 03-12-2015 |
Jacobus A.j. Van Dun, Kasserlee BE
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20110065684 | PHTHALAZINE DERIVATIVES AS PARP INHIBITORS - The present invention provides compounds of formula (I), their use as PARP inhibitors as well as pharmaceutical compositions comprising said compounds of formula (I) | 03-17-2011 |
Jacobus Alphonsus Josephus Van Dun, Kasterlee BE
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20080249099 | 7-Phenylalkyl Substituted 2-Quinolinones and 2-Quinoxalinones as Poly(Adp-Ribose) Polymerase Inhibitors - The present invention provides compounds of formula (I), their use as PARP inhibitors as well as pharmaceutical compositions comprising said compounds of formula (I) | 10-09-2008 |
20090042881 | SUBSTITUTED 6-CYCLOHEXYLALKYL SUBSTITUTED 2-QUINOLINONES AND 2-QUINOXALINONES AS POLY(ADP-RIBOSE) POLYMERASE INHIBITORS - The present invention provides compounds of formula (I), their use as PARP inhibitors as well as pharmaceutical compositions comprising said compounds of formula (I) | 02-12-2009 |
20110077245 | SUBSTITUTED 2-ALKYL QUINAZOLINONE DERIVATIVES AS PARP INHIBITORS - The present invention provides compounds of formula (I), their use as PARP inhibitors as well as pharmaceutical compositions comprising said compounds of formula (I) | 03-31-2011 |
20110124673 | 6-ALKENYL AND 6-PHENYLALKYL SUBSTITUTED 2-QUINOLINONES AND 2-QUINOXALINONES AS POLY(ADP-RIBOSE) POLYMERASE INHIBITORS - The present invention provides compounds of formula (I) and compounds of formula (VII-a) as well as pharmaceutical compositions comprising said compounds and their use as PARP inhibitors | 05-26-2011 |
20120046274 | 6-ALKENYL AND 6-PHENYLALKYL SUBSTITUTED 2-QUINOLINONES AND 2-QUINOXALINONES AS POLY(ADP-RIBOSE) POLYMERASE INHIBITORS - The present invention provides compounds of formula (I) and compounds of formula (VII-a) as well as pharmaceutical compositions comprising said compounds and their use as PARP inhibitors | 02-23-2012 |
20120065216 | QUINAZOLINEDIONE DERIVATIVES AS PARP INHIBITORS - The present invention provides compounds of formula (I), their use as PARP inhibitors as well as pharmaceutical compositions comprising said compounds of formula (I) | 03-15-2012 |
20140080835 | QUINAZOLINONE DERIVATIVES AS PARP INHIBITORS - The present invention provides compounds of formula (I), their use as PARP inhibitors as well as pharmaceutical compositions comprising said compounds of formula (I) | 03-20-2014 |
20140100239 | QUINAZOLINEDIONE DERIVATIVES AS PARP INHIBITORS - The present invention provides compounds of formula (I), their use as PARP inhibitors as well as pharmaceutical compositions comprising said compounds of formula (I) | 04-10-2014 |
Jacobus Alphonsus Josephus Van Dun, Tielen BE
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20110230491 | 6-SUBSTITUTED 2-QUINOLINONES AND 2-QUINOXALINONES AS POLY(ADP-RIBOSE) POLYMERASE INHIBITORS - The present invention provides compounds of formula (I), their use as PARP inhibitors as well as pharmaceutical compositions comprising said compounds of formula (I) | 09-22-2011 |
20110230492 | 7-PHENYLALKYL SUBSTITUTED 2-QUINOLINONES AND 2-QUINOXALINONES AS POLY(ADP-RIBOSE) POLYMERASE INHIBITORS - The present invention provides compounds of formula (I), their use as PARP inhibitors as well as pharmaceutical compositions comprising said compounds of formula (I) | 09-22-2011 |
Jacobus Alphonsus Josephus Van Dun, Beerse BE
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20130237528 | 6-ALKENYL AND 6-PHENYLALKYL SUBSTITUTED 2-QUINOLINONES AND 2-QUINOXALINONES AS POLY(ADP-RIBOSE) POLYMERASE INHIBITORS - The present invention provides compounds of formula (I) and compounds of formula (VII-a) as well as pharmaceutical compositions comprising said compounds and their use as PARP inhibitors | 09-12-2013 |
Joaanes Petrus Van Dun, Lille BE
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20120071660 | RESOLUTION OF (.+-.)-METHYL PHENYL[4-[4-[[[4'(TRIFLUOROMETHYL)-2- BIPHENYLYL]CARBONYL]AMINO]PHENYL]-1-PIPERIDINYL]ACETATE - The present invention relates to a resolution process of (±)-methyl phenyl[4-[4-[[[4′-(trifluoromethyl)-2-biphenylyl]carbonyl]amino]phenyl]-1-piperidinyl]acetate to isolate the MTP (microsomal triglyceride transfer protein) inhibitor methyl (2S)-phenyl[4-[4-[[[4′-(trifluoromethyl)-2-biphenylyl]carbonyl]amino]phenyl]-1-piperidinyl]acetate and an epimerisation procedure for racemizing methyl (2R)-phenyl[4-[4-[[[4′-(trifluoromethyl)-2-biphenylyl]carbonyl]amino]phenyl]-1-piperidinyl]acetate. | 03-22-2012 |
Joannes Petrus Van Dun, Lille BE
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20080214808 | Preparation of Aseptic 3-[2-[4-((6-Fluoro-1,2-Benzisoxazol-3-Yl)-1-Piperidinyl]-6,7,8,9-Tetrahydro-9-Hydroxy-2-Methyl-4H-Pyrido[1,2-a]Pyrimidin-4-One Palmitate Ester - The present invention concerns a process for preparing aseptic crystalline 3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one palmitate ester (I) substantially free of 3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one (II-a), 3-[2-[4-(6-fluoro-1,2-benzisoxazol-3 -yl)-1-piperidinyl]ethyl]-6,7-dihydro-2-methyl-4H-pyrido[1,2-a]-pyrimidin-4-one (II-b), and 3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]-ethyl]-6,7,8,9-tetrahydro-2-methyl-9-pentadecyl-4H-pyrido[1,2-a]pyrimidin-4-one (III), and having an average particle size ranging from 20 to 150 μm. | 09-04-2008 |
Josef J. Van Dun, Zandhoven BE
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20130075409 | FUEL CONTAINERS MADE FROM POLYETHYLENE COMPOSITIONS WITH IMPROVED CREEP RESISTANCE - Fuel containers made from polyethylene compositions exhibiting improved creep resistance are provided. The polyethylene compositions include two components, a first component ethylene-based interpolymer, and a second component ethylene-based polymer. A process for producing a fuel container from the polyethylene compositions by blow molding is also provided. The fuel containers may include vehicle fuel tanks. | 03-28-2013 |
Jozef Van Dun, Zandhoven BE
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20110129631 | IGNITION RESISTANT CARBONATE POLYMER COMPOSITION - The present invention is an ignition resistant carbonate polymer composition, a method to make said composition and fabricated articles made therefrom. The ignition resistant carbonate polymer composition comprises: (i) an aromatic polycarbonate or an aromatic polyester carbonate, (ii) a graft polymer, (iii) optionally one or more thermoplastic vinyl (co)polymer, (iv) optionally one or more thermoplastic polyester polymer, (v) an aromatic phosphate compound, and (vi) a mixture of a fibril forming polytetrafluoroethylene polymer and a fluorothermoplast. | 06-02-2011 |
Jozef J. Van Dun, Zandhoven BE
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20080199673 | Propylene Based Meltblown Nonwoven Layers and Composite Structures - The present invention relates to propylene-based nonwoven layers made by the meltblown process, and laminates incorporating such layers. The meltblown layers of the present invention comprise propylene copolymers characterized by having less than 50 percent crystallinity. The meltblown layers of the present invention show an improved combination of extensibility and tensile strength. The laminate structures of the present invention are characterized by a combination of low bending modulus with high peel strength. | 08-21-2008 |
20090111347 | SOFT AND EXTENSIBLE POLYPROPYLENE BASED SPUNBOND NONWOVENS - The present invention relates to nonwoven webs or fabrics. In particular, the present invention relates to nonwoven webs having superior abrasion resistance and excellent softness characteristics. The nonwoven materials comprise fibers made from of a polymer blend of isotactic polypropylene and reactor grade propylene based elastomers or plastomers together with from about 100 to about 2500 ppm (by weight of the fiber) of a slip agent. The isotactic polypropylene can be homopolymer polypropylene, and/or random copolymers of propylene and one or more alpha-olefins. The reactor grade propylene based elastomers or plastomers have a molecular weight distribution of less than about 3.5, and a heat of fusion less than about 90 joules/gm. In particular, the reactor grade propylene based elastomers or plastomers contains from about 3 to about 15 percent by weight of units derived from an ethylene and a melt flow rate of from about 2 to about 200 grams/10 minutes. Erucamide is the preferred slip additive. | 04-30-2009 |
20100292407 | PROCESS FOR PREPARING COPOLYMERS AND BLEND COMPOSITIONS CONTAINING THE SAME - Disclosed is a novel ethylene copolymer by copolymerizing an ethylene and at least one comonomer selected from a compound represented by the formula H | 11-18-2010 |
Jozef J. I. Van Dun, Zandhoven BE
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20080293890 | Elastomeric Resin Compositions with Improved Resistance to Draw Resonance - This invention relates to polyolefin compositions. In particular, the invention pertains to elastic polymer compositions that can be more easily processed on cast film lines, extrusion lamination or coating lines due to improved resistance to draw resonance. The compositions of the present invention comprise an elastomeric polyolefin resin and a high pressure low density type resin. The preferred compositions of the present invention comprise from 88 to 99 percent elastomer or plastomer and from 1 to 12 percent by weight of a high pressure low density type resin. | 11-27-2008 |