O'Brien, GB
Conall O'Brien, Cheshire GB
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20150371227 | Registering a Mobile User - Method and system of registering a user of a mobile device comprising: obtaining data identifying a user. Obtaining account data. Retrieving data uniquely identifying a mobile device. Authenticating the user with the mobile device. Validating the user with the account using the data identifying the user and the account data. | 12-24-2015 |
Daniel O'Brien, Stonehaven GB
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20140000911 | Apparatus and Method for Use In Slim Hole Wells | 01-02-2014 |
20160003000 | Improved Isolation Barrier - An apparatus ( | 01-07-2016 |
Darragh P.w. O'Brien, Cobham GB
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20120071337 | METHODS - The invention provides a method for aiding the diagnosis or prognostic monitoring of Alzheimer's disease in a subject, said method comprising; providing a sample of blood obtained from said patient; assaying the amount of gelsolin present in said sample; comparing the amount of gelsolin present in said sample to a reference amount of gelsolin present in a sample from a healthy subject, wherein detection of a gelsolin level in the sample from said patient which is lower than the gelsolin level in the reference sample indicates an increased likelihood of Alzheimer's disease in said patient. Other markers are C1 protease inhibitor and ceruloplasmin. Both blood samples and tissue samples have been investigated. | 03-22-2012 |
David John O'Brien, Oxhey GB
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20140001185 | Seal Stock Laminate | 01-02-2014 |
David John O'Brien, Hertfordshire GB
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20090304964 | Vessel Closing Laminate - A vessel closing laminate comprising: a seal laminate ( | 12-10-2009 |
20100193463 | Seal For A Container - A seal for a container for comestibles, especially portable liquids, and in particular for use for sealing polyester containers such as bottles, which is suitable for passage through a PET recycling process, comprises a metal foil layer, a foam layer and a plastics film layer as well as a heat sealable layer below the foil. The foam is selected for its density and thickness so is to confer upon the seal a high buoyancy. The adhesion a between the foam and the foil is increased compared to currently available products, in order to prevent de-lamination between the foil and the foam during the recycling process. | 08-05-2010 |
David John O'Brien, Oxney GB
Patent application number | Description | Published |
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20120107577 | Vessel Closing Laminate - A vessel closing laminate comprising: a seal laminate comprising a bottom subassembly of layers including a foil layer; and a seal substrate attached to the uppermost layer of the bottom subassembly of layers wherein the seal substrate has a bottom foam layer and a top plastic material layer and further includes a free tab lying wholly within the circumference of the seal; a wax layer on top of the plastic material layer of the seal substrate; and an absorbent liner adhered to the plastic material layer of the seal substrate by means of the wax layer. | 05-03-2012 |
Dominic O'Brien, Oxford GB
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20100209119 | APPARATUS FOR CONTROLLING LIGHTING EQUIPMENT FOR LIGHTING COMMUNICATION - Disclosed is an apparatus for controlling an illumination device for optical communication, including an optical array having a plurality of light emitting elements, a visible ray communication unit for outputting an electrical signal for visible ray communication, an optical array driving unit for providing a control signal for individually controlling ON/OFF of the plurality of light emitting elements, and a logic operation unit for performing logic operations on signals provided from the visible ray communication unit and the optical array driving unit, and outputting resultant operated signals to the optical array. | 08-19-2010 |
20110110668 | VISIBLE-LIGHT WIRELESS COMMUNICATION METHOD AND SYSTEM - A visible-light wireless communication system includes a plurality of light transmitters for generating light signals modulated at different frequencies and at least one terminal for wirelessly communicating with the plurality of light transmitters using the light signals. | 05-12-2011 |
Dominic Christopher O'Brien, Oxfordshire GB
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20150244457 | Apparatus For Data Communications, Method Of Performing Data Communications - Apparatus and methods for data communications are disclosed. In a disclosed arrangement, there is provided an apparatus for data communications, comprising: a detector for detecting electromagnetic radiation; a decoder for obtaining information from the detected electromagnetic radiation; and a concentration stage for receiving and concentrating the radiation, prior to detection of the radiation by the detector, the concentration stage comprising a wavelength converting element configured to convert radiation to longer wavelength radiation. | 08-27-2015 |
Eamonn J. O'Brien, Hillsborough, County Down GB
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20160002732 | MOLECULAR DIAGNOSTIC TEST FOR CANCER - Methods and compositions are provided for the identification of a molecular diagnostic test for cancer. The test identifies cancer subtypes that have an up-regulation or a down-regulation in biomarker expression related to angiogenesis and vascular development. The present invention can be used to determine whether patients with cancer are clinically responsive or non-responsive to a therapeutic regimen prior to administration of any anti-angiogenic agent. This test may be used in different cancer types and with different drugs that directly or indirectly affect angiogenesis or angiogenesis signalling. In addition, the present invention may be used as a prognostic indicator for certain cancer types. In particular, the present invention is directed to the use of certain combinations of predictive markers, wherein the expression of the predictive markers correlates with responsiveness or non-responsiveness to a therapeutic regimen. | 01-07-2016 |
Eamonn J. O'Brien, Hillsborough GB
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20140342924 | Molecular Diagnostic Test for Cancer - Methods and compositions are provided for the identification of a molecular diagnostic test for cancer. The test identifies cancer subtypes that are responsive to anti-angiogenesis therapeutics and enables classification of a patient within this subtype. The present invention can be used to determine whether patients with cancer are clinically responsive or non-responsive to a therapeutic regimen prior to administration of any anti-angiogenic agent. This test may be used in different cancer types and with different drugs that directly or indirectly affect angiogenesis or angiogenesis signalling. In addition, the present invention may be used as a prognostic indicator for certain cancer types. In particular, the present invention is directed to the use of certain combinations of predictive markers, wherein the expression of the predictive markers correlates with responsiveness or non-responsiveness to a therapeutic regimen. | 11-20-2014 |
Edwin William O'Brien, Bristol GB
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20090265120 | METHOD AND APPARATUS FOR MONITORING A STRUCTURE - A method of monitoring a structure, the method comprising positioning one or more strain gauges on the structure; acquiring strain data with the gauges(s); analyzing the strain data to determine whether the structure has undergone plastic deformation; and providing an output in accordance with the analysis. | 10-22-2009 |
Gerard D. O'Brien, Richmond GB
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20090037340 | Digital certification method and apparatus - A document is recorded with authenticity certification information by receiving an indication that a client is prepared to indicate acceptance and/or receipt of a proposed set of documentary content elements. A visual display of the documentary content elements is presented. An actuatable acknowledgment mechanism and a field for receipt of account information is presented. The actuation of said actuatable acknowledgment mechanism is detected and the account information is transmitted to an account provider. Asymmetric key pairs from one or more items associated with the account are generated. A digital certificate derived from one or more items associated with the account is generated. | 02-05-2009 |
20090076962 | DIGITAL CERTIFICATION METHOD AND APPARATUS - A method for recording a document with authenticity certification information. The method includes receiving an indication from a user regarding their intention to accept and/or receive a proposed set of documentary content elements and presenting a visual display of the documentary content elements. The method further includes presenting and detecting an actuatable acknowledgment mechanism and receiving and transmitting account information to an account provider. The method also includes generating a digital certificate and key pairs from one or more items associated the account information. | 03-19-2009 |
Gerard D. O'Brien, Surrey GB
Patent application number | Description | Published |
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20110088090 | ENHANCEMENTS TO CLAIMS BASED DIGITAL IDENTITIES - A system and method of identifying a user to a digital system is disclosed. The method includes receiving a request for a value of an identification claim of a digital identity from a relying party, allowing a user to select the digital identity via an identification selector, querying an identification provider for the value of the identification claim, and providing the value of the identification claim to the relying party. | 04-14-2011 |
20130132726 | DIGITAL CERTIFICATION METHOD AND APPARATUS - A method for recording a document with authenticity certification information. The method includes receiving an indication from a user regarding their intention to accept and/or receive a proposed set of documentary content elements and presenting a visual display of the documentary content elements. The method further includes presenting and detecting an actuatable acknowledgment mechanism and receiving and transmitting account information to an account provider. The method also includes generating a digital certificate and key pairs from one or more items associated the account information. | 05-23-2013 |
Harry Richard Stanley O'Brien, Elrick, Aberdeenshire GB
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20150361731 | ROLLER DEVICE - A roller device for incorporation into a wireline tool string for use in an oil or gas well has a body with rollers comprising captive bearings arranged on the outer surface of the body to rotate around more than one axis relative to the body, and wherein the rollers are arranged in at least one or more helix around the body. Each helix completes at least one full circumferential turn around the body. The rollers circumferentially overlap one another on the body, so that when the body engages the inner wall of the wellbore, the entire circumference of the body is supported by at least one roller. | 12-17-2015 |
Jeremy O'Brien, Bristol GB
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20120195430 | Quantum Key Distribution - An apparatus including: an input optical interface configured to receive a series of optical input signals each including photons; an encoder configured to encode a quantum key for distribution by encoding each of the series of received optical input signals with a measurable state; an attenuator configured to attenuate each of the encoded optical input signals to create a series of quantum optical signals; and an output optical interface configured to send the series of quantum optical signals to the remote apparatus via a quantum communication channel. | 08-02-2012 |
Jeremy Lloyd O'Brien, Bristol GB
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20150261058 | OPTICAL SOURCE - An integrated optical device and method for generating photons by manipulating path entanglement is provided. An integrated optical splitter splits pump light between two interferometer arms wherein each arm comprises a substantially identical photon pair source configured to be able to convert at least one pump light photon into a signal and idler photon pair. An integrated optical combiner device in optical communication with a first and a second optical output path interferes light from the first and second arms and outputs the signal and idler photons by bunching the signal and idler photons together in one of the optical output paths, or anti-bunching the signal photon in one output path and the corresponding idler photon in the other optical output path. | 09-17-2015 |
John O'Brien, Leicester GB
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20150258698 | Manufacture of Potato Chips - A potato chip cutting apparatus, the apparatus comprising an annular-shaped cutting head and a central impeller coaxially mounted for rotation within the cutting head for delivering potatoes radially outwardly toward the cutting head, the impeller having a base with an upper surface across which potatoes are, in use, delivered to the cutting head, a plurality of knives serially mounted annularly around the cutting head, each knife having a first cutting edge extending substantially vertically and spaced from the cutting head to provide a gap between the first cutting edge and the cutting head, each knife also having a second cutting edge extending substantially horizontally and extending radially at least partly across the gap, the second cutting edge being located at least 50 mm above the upper surface of the impeller to define a cutting zone for cutting a single potato slice between the upper surface and the second cutting edge. | 09-17-2015 |
John O'Brien, Walton On Thames GB
John O'Brien, Buckinghamshire GB
Patent application number | Description | Published |
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20090049965 | BOOK TRIMMING APPARATUS - The book trimming apparatus comprises guides ( | 02-26-2009 |
20140130648 | BOOK TRIMMING APPARATUS - The book trimming apparatus includes guides which direct a collated and, optionally, bound book to a fore-edge trimming station. The book trimming apparatus further includes a transfer station and a side-edge trimming station. For both the fore-edge trimming station and the side-edge trimming station in each case the book is orientated so that the edge to be trimmed is arranged substantially parallel to the direction of motion of the book. The automated book trimming apparatus is particularly suited for use in combination with collation and binding stations in in-line book manufacture. | 05-15-2014 |
John P. O'Brien, Rutland GB
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20150344035 | SYSTEMS AND METHODS FOR CONTROLLING ENGINE SHUTDOWN OF A VEHICLE EQUIPPED WITH START-STOP LOGIC AND VEHICLE LAUNCH - Controls for improved drivability of a vehicle equipped with start/stop logic are disclosed. One exemplary embodiment is a method comprising stopping an internal combustion engine of the vehicle to achieve a target speed profile during slowing of the engine to reduce noise, vibration and harshness, and/or to achieve a target engine stop position. Another embodiment is a method for selecting between a nominal re-start mode and a delayed re-start mode where launching of the vehicle after a stop is delayed relative to the nominal start mode in response to a vehicle input. | 12-03-2015 |
Lee O'Brien, Welwyn Garden City GB
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20120157275 | METHOD AND SYSTEM FOR DETECTING WEAR IN IMAGING DEVICES - Methods and system for detecting wear in imaging devices. The system includes an outer wearable layer. An inner layer fused to the outer layer. The inner layer is made of multiple microcapsules including odiferous oils. Wearing off of the outer layer, over time, exposes the inner layer. Subsequently, with added pressure on the inner layer, the microcapsules crack, giving off a particular scent. By detecting the smell, customers can identify worn components of the imaging devices. | 06-21-2012 |
Lee James O'Brien, Welwyn Garden City GB
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20100253952 | METHOD AND APPARATUS FOR CONFIRMING ATTRIBUTES OF MEDIA LOADED IN A MEDIA TRAY IN AN IMAGE PRODUCTION DEVICE - A method and apparatus for confirming attributes of media loaded in a media tray in an image production device is disclosed. The method may include determining which media tray of one or more media trays is being loaded with media using one or more media tray sensors, displaying a graphical representation of the media tray being loaded to a user on a user interface, prompting the user to enter and confirm attributes of the media being loaded into the media tray through the user interface, determining if confirmation has been received from the user interface, wherein if it is determined that the confirmation has been received from the user interface, storing the confirmed attributes for the determined media tray in a memory, and processing print jobs using the stored media tray attributes. | 10-07-2010 |
Liam O'Brien, London GB
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20140316360 | CONVEX SUPPORTING DEVICE - A base plate comprising an adhesive wafer and a convex supporting device. An ostomy appliance comprising a base plate with an adhesive wafer and a convex supporting device. | 10-23-2014 |
20150018790 | OSTOMY WAFER - An ostomy wafer ( | 01-15-2015 |
Liam James O'Brien, London GB
Lyn Margaret O'Brien, Salisbury GB
Patent application number | Description | Published |
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20120244150 | ANTI-VEEV HUMANIZED ANTIBODY - The present disclosure relates to an anti-VEEV humanised antibody or a fragment thereof comprising a framework 1, 2, 3, 4, S or 6 CDR regions independently selected from SEQ ID Nos: 2, 3, 4, 5, 6 or 7 characterised in that the antibody or fragment comprises in the framework at least one amino acid, that positively influences the binding/activity of the antibody, from the original murine antibody 1A3B7, pharmaceutical composition comprising same, methods of preparing the antibody or fragment and use of the antibody or fragment in treatment or prophylaxis, in particular the treatment or prophylaxis of VEEV infection. | 09-27-2012 |
Matthew O'Brien, Royston GB
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20150273452 | DIESEL OXIDATION CATALYST WITH NOx ADSORBER ACTIVITY - An oxidation catalyst for treating an exhaust gas from a diesel engine and an exhaust system comprising the oxidation catalyst are described. The oxidation catalyst comprises: a first washcoat region for adsorbing NO | 10-01-2015 |
Matthew O'Brien, Newcastle Upon Tyne GB
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20150208838 | VALVE ASSEMBLY - According to a first embodiment, the valve assembly comprises a first arm having a first valve portion and a second arm having a second valve portion. The valve assembly is foldable from an unfolded state to a folded state, such that the first valve portion engages with the second valve portion. According to a second embodiment, the valve assembly comprises a liquid inlet, a liquid outlet, a conduit, a blocking member, and a flexible member arranged to seal against the blocking member. The conduit comprises at least one bend and is arranged such that fluid may flow from the liquid inlet, past the bend and through the liquid outlet to at least indirectly impinge the flexible member. | 07-30-2015 |
Michael Alistair O'Brien, Hertfordshire GB
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20100152184 | PHARMACEUTICAL COMPOUNDS - The invention provides a compound for use in medicine, the compound being a compound of the formula (VI | 06-17-2010 |
Michael Alistair O'Brien, Herts GB
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20080306069 | Pyrazole Derivatives for the Inhibition of CDK'S and GSK'S - The invention provides compounds of the formula (I), or salts, tautomers, N-oxides or solvates thereof wherein: R1 is selected from: (a) 2,6-dichlorophenyl; (b) 2,6-difluorophenyl; (c) a 2,3,6-trisubstituted phenyl group wherein the substituents for the phenyl group are selected from fluorine, chlorine, methyl and methoxy; (d) a group RO; (e) a group R a; (f) a group RIb; (g) a group RIc; (h) a group RId; and 0) 2,6-difluorophenylamino; wherein R) 0υ, r R>llaa, T Rj HbD, T R) HcC, r R>Iidα, r R>>2zaa, r R>22bD and RJ are as defined in the claims. The compounds have activity as inhibitors of cdk kinase (such as cdk1 or cdk2) and glycogen synthase kinase-3 activity. | 12-11-2008 |
Michael Alistair O'Brien, Cambridge GB
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20140371213 | 3,4-DISUBSTITUTED 1H-PYRAZOLE COMPOUNDS AND THEIR USE AS CYCLIN DEPENDENT KINASE AND GLYCOGEN SYNTHASE KINASE-3 MODULATORS - The invention provides compounds of the formula (0) or salts or tautomers or N-oxides or solvates thereof for use in the prophylaxis or treatment of disease states and conditions such as cancers mediated by cyclin-dependent kinase and glycogen synthase kinase-3. | 12-18-2014 |
Michael Gerard O'Brien, Rickmansworth GB
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20130206791 | PORTABLE HANDHELD LIQUID DISPENSER - The present invention provides a dispenser ( | 08-15-2013 |
Padriac O'Brien, Liverpool GB
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20090270438 | Novel compositions and formulations - There is provided according to the invention a non-pressurised pharmaceutical liquid solution spray composition comprising: (i) buprenorphine; and a solvent comprising ethanol which composition is substantially free of chloride. There is also provided according to the invention a non-pressurised pharmaceutical liquid solution spray formulation comprising: (i) buprenorphine; (ii) a solvent comprising ethanol; and (iii) one or more antioxidants each of a molar ratio of antioxidant:buprenorphine between 0.2:1 and 25:1. | 10-29-2009 |
Patrick Damien O'Brien, Cheshire GB
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20140287819 | METHOD, APPARATUS, AND COMPUTER-READABLE MEDIA FOR ENABLING REAL-TIME COMPETITION HAVING AN ENTERTAINING EXPERIENCE BASED ON COMMODITIES OR CURRENCIES - The disclosed embodiment relates to methods, apparatus, and computer-readable media for enabling real-time competition. An exemplary computer-implemented method executed by one or more computing devices for enabling real-time competition between users according to the disclosed embodiment includes, for example, receiving information from a first user computing device associated with a first user corresponding to the first user's competitive position regarding a real-time event, transmitting information to a second user computing device associated with a second user identifying the real-time event, receiving information from the second user computing device corresponding to the second user's competitive position regarding the real-time event, and transmitting information to the first user computing device and the second user computing device regarding an outcome of the real-time event relative to the first user's competitive position and the second user's competitive position. | 09-25-2014 |
20140309014 | METHOD, APPARATUS, AND COMPUTER-READABLE MEDIA FOR ENABLING REAL-TIME COMPETITION HAVING AN ENTERTAINING EXPERIENCE BASED ON COMMODITIES OR CURRENCIES - Methods, apparatus, and computer-readable media for enabling real-time competition based on commodities. An exemplary computer-implemented method executed by one or more computing devices for enabling real-time competition based on commodities includes receiving information from a first user including a selection of a commodity and a competitive position corresponding to a criteria associated with the commodity, determining, based at least in part on real-time information regarding the selected commodity, whether the competitive position regarding the criteria is consistent with the real-time information, transmitting information to the first user indicating an outcome that is favorable based at least in part of a determination that the competitive position regarding the criteria is consistent with the real-time information, and transmitting information to the first user indicating an outcome that is not favorable based at least in part of a determination that the competitive position regarding the criteria is not consistent with the real-time information. | 10-16-2014 |
20140342793 | METHOD, APPARATUS, AND COMPUTER-READABLE MEDIA FOR ENABLING REAL-TIME COMPETITION BASED ON COMMODITIES - Methods, apparatus, and computer-readable media for enabling real-time competition based on a commodity. An exemplary computer-implemented method comprises receiving information corresponding to a selection of a commodity and a competitive position associated with the commodity, the competitive position being based on the value of the commodity over a specified duration of time, transmitting information to a computing device associated with the user for display as an entertaining experience during the specified duration of time, the entertaining experience including a real-time state of the competitive position relative to the real-time value of the commodity, and transmitting, after the specified duration of time has ended, outcome information to the computing device associated with the user, the outcome information indicating whether the real-time data at the end of the specified duration of time was consistent with the competitive position. | 11-20-2014 |
20150228023 | METHOD, APPARATUS, AND COMPUTER-READABLE MEDIA FOR ENABLING REAL-TIME COMPETITION HAVING AN ENTERTAINING EXPERIENCE BASED ON COMMODITIES OR CURRENCIES - Methods, apparatus, and computer-readable media for enabling real-time competition based on commodities. An exemplary computer-implemented method executed by one or more computing devices for enabling real-time competition based on commodities includes receiving information from a first user including a selection of a commodity and a competitive position corresponding to a criteria associated with the commodity, determining, based at least in part on real-time information regarding the selected commodity, whether the competitive position regarding the criteria is consistent with the real-time information, transmitting information to the first user indicating an outcome that is favorable based at least in part of a determination that the competitive position regarding the criteria is consistent with the real-time information, and transmitting information to the first user indicating an outcome that is not favorable based at least in part of a determination that the competitive position regarding the criteria is not consistent with the real-time information. | 08-13-2015 |
20150231495 | METHOD, APPARATUS, AND COMPUTER-READABLE MEDIA FOR ENABLING REAL-TIME COMPETITION HAVING AN ENTERTAINING EXPERIENCE BASED ON COMMODITIES OR CURRENCIES - The disclosed embodiment relates to methods, apparatus, and computer-readable media for enabling real-time competition. An exemplary computer-implemented method executed by one or more computing devices for enabling real-time competition between users according to the disclosed embodiment includes, for example, receiving information from a first user computing device associated with a first user corresponding to the first user's competitive position regarding a real-time event, transmitting information to a second user computing device associated with a second user identifying the real-time event, receiving information from the second user computing device corresponding to the second user's competitive position regarding the real-time event, and transmitting information to the first user computing device and the second user computing device regarding an outcome of the real-time event relative to the first user's competitive position and the second user's competitive position. | 08-20-2015 |
Paul O'Brien, High Peak GB
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20080220593 | Nanoparticles - Method for producing a nanoparticle comprised of core, first shell and second shell semiconductor materials. Effecting conversion of a core precursor composition comprising separate first and second precursor species to the core material and then depositing said first and second shells. The conversion is effected in the presence of a molecular cluster compound under conditions permitting seeding and growth of the nanoparticle core. Core/multishell nanoparticles in which at least two of the core, first shell and second shell materials incorporate ions from groups 12 and 15, 14 and 16, or 11, 13 and 16 of the periodic table. Core/multishell nanoparticles in which the second shell material incorporates at least two different group 12 ions and group 16 ions. Core/multishell nanoparticles in which at least one of the core, first and second semiconductor materials incorporates group 11, 13 and 16 ions and the other semiconductor material does not incorporate group 11, 13 and 16 ions. | 09-11-2008 |
20110070147 | Preparation of Nanoparticle Materials - A method of producing nanoparticles comprises effecting conversion of a nanoparticle precursor composition to the material of the nanoparticles. The precursor composition comprises a first precursor species containing a first ion to be incorporated into the growing nanoparticles and a separate second precursor species containing a second ion to be incorporated into the growing nanoparticles. The conversion is effected in the presence of a molecular cluster compound under conditions permitting seeding and growth of the nanoparticles. | 03-24-2011 |
20110070443 | Preparation of Nanoparticle Materials - A method of producing nanoparticles comprises effecting conversion of a nanoparticle precursor composition to the material of the nanoparticles. The precursor composition comprises a first precursor species containing a first ion to be incorporated into the growing nanoparticles and a separate second precursor species containing a second ion to be incorporated into the growing nanoparticles. The conversion is effected in the presence of a molecular cluster compound under conditions permitting seeding and growth of the nanoparticles. | 03-24-2011 |
20110108799 | NANOPARTICLES - Method for producing a nanoparticle comprised of core, first shell and second shell semiconductor materials. Effecting conversion of a core precursor composition comprising separate first and second precursor species to the core material and then depositing said first and second shells. The conversion is effected in the presence of a molecular cluster compound under conditions permitting seeding and growth of the nanoparticle core. Core/multishell nanoparticles in which at least two of the core, first shell and second shell materials incorporate ions from groups 12 and 15, 14 and 16, or 11, 13 and 16 of the periodic table. Core/multishell nanoparticles in which the second shell material incorporates at least two different group 12 ions and group 16 ions. Core/multishell nanoparticles in which at least one of the core, first and second semiconductor materials incorporates group 11, 13 and 16 ions and the other semiconductor material does not incorporate group 11, 13 and 16 ions. | 05-12-2011 |
20120025155 | Preparation of Nanoparticle Materials - A method of producing nanoparticles comprises effecting conversion of a nanoparticle precursor composition to the material of the nanoparticles. The precursor composition comprises a first precursor species containing a first ion to be incorporated into the growing nanoparticles and a separate second precursor species containing a second ion to be incorporated into the growing nanoparticles. The conversion is effected in the presence of a molecular cluster compound under conditions permitting seeding and growth of the nanoparticles. | 02-02-2012 |
20140091257 | Preparation of Nanoparticle Materials - A method of producing nanoparticles comprises effecting conversion of a nanoparticle precursor composition to the material of the nanoparticles. The precursor composition comprises a first precursor species containing a first ion to be incorporated into the growing nanoparticles and a separate second precursor species containing a second ion to be incorporated into the growing nanoparticles. The conversion is effected in the presence of a molecular cluster compound under conditions permitting seeding and growth of the nanoparticles. | 04-03-2014 |
Peter O'Brien, Sunderland GB
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20150097417 | HYDRAULIC ACCUMULATOR PRE-CHARGE PRESSURE DETECTION FOR HYDRAULIC BRAKING SYSTEM - A system and method for detecting a pre-charge pressure of a hydraulic braking system are disclosed. A controller receives pressure readings from a pressure sensor indicative of the pressure of a hydraulic brake accumulator or the lower pressure of more than one accumulator. In response to fluid being provided to the hydraulic accumulator, the controller determines a first rate of pressure change, a second rate of pressure change different than the first rate, and a transition pressure between the first and second rates. The controller determines an approximate pre-charge pressure of the hydraulic brake accumulator based on the transition pressure. A warning can be provided to the operator or another when the determined pre-charge pressure is lower than a reference pressure. | 04-09-2015 |
Siobhan H. O'Brien, London GB
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20080241136 | Humanized Anti-CCR2 Antibodies and Methods of Use Therefor - The present invention relates to a humanized antibody or functional fragment thereof which binds to a mammalian (e.g., human) CC-chemokine receptor 2 (CCR2) or a portion of the receptor and blocks binding of a ligand to the receptor. The invention further relates to a method of inhibiting the interaction of a cell bearing mammalian CCR2 with a ligand thereof, and to use of the antibodies and fragments in therapeutic, prophylactic and diagnostic methods. | 10-02-2008 |
20080241923 | Humanized Anti-CCR2 Antibodies and Methods of Use Therefor - The present invention relates to a humanized antibody or functional fragment thereof which binds to a mammalian (e.g., human) CC-chemokine receptor 2 (CCR2) or a portion of the receptor and blocks binding of a ligand to the receptor. The invention further relates to a method of inhibiting the interaction of a cell bearing mammalian CCR2 with a ligand thereof, and to use of the antibodies and fragments in therapeutic, prophylactic and diagnostic methods. | 10-02-2008 |
20080268536 | Humanized Anti-CCR2 Antibodies and Methods of Use Therefor - The present invention relates to a humanized antibody or functional fragment thereof which binds to a mammalian (e.g., human) CC-chemokine receptor 2 (CCR2) or a portion of the receptor and blocks binding of a ligand to the receptor. The invention further relates to a method of inhibiting the interaction of a cell bearing mammalian CCR2 with a ligand thereof, and to use of the antibodies and fragments in therapeutic, prophylactic and diagnostic methods. | 10-30-2008 |
20090142339 | Humanized Anti-CCR2 Antibodies and Methods of Use Therefor - The present invention relates to a humanized antibody or functional fragment thereof which binds to a mammalian (e.g., human) CC-chemokine receptor 2 (CCR2) or a portion of the receptor and blocks binding of a ligand to the receptor. The invention further relates to a method of inhibiting the interaction of a cell bearing mammalian CCR2 with a ligand thereof, and to use of the antibodies and fragments in therapeutic, prophylactic and diagnostic methods. | 06-04-2009 |
20090169541 | Humanized Anti-CCR2 Antibodies and Methods of Use Therefor - The present invention relates to a humanized antibody or functional fragment thereof which binds to a mammalian (e.g., human) CC-chemokine receptor 2 (CCR2) or a portion of the receptor and blocks binding of a ligand to the receptor. The invention further relates to a method of inhibiting the interaction of a cell bearing mammalian CCR2 with a ligand thereof, and to use of the antibodies and fragments in therapeutic, prophylactic and diagnostic methods. | 07-02-2009 |
Siobhan H. O'Brien, Herts GB
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20090191192 | HUMANIZED ANTI-CCR2 ANTIBODIES AND METHODS OF USE THEREFOR - The present invention relates to a humanized antibody or functional fragment thereof which binds to a mammalian (e.g., human) CC-chemokine receptor 2 (CCR2) or a portion of the receptor and blocks binding of a ligand to the receptor. The invention further relates to a method of inhibiting the interaction of a cell bearing mammalian CCR2 with a ligand thereof, and to use of the antibodies and fragments in therapeutic, prophylactic and diagnostic methods. | 07-30-2009 |
Siobhan H. O'Brien, Bishops Stortford GB
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20130071381 | HUMANIZED ANTI-CCR2 ANTIBODIES AND METHODS OF USE THEREFOR - The present invention relates to a humanized antibody or functional fragment thereof which binds to a mammalian (e.g., human) CC-chemokine receptor 2 (CCR2) or a portion of the receptor and blocks binding of a ligand to the receptor. The invention further relates to a method of inhibiting the interaction of a cell bearing mammalian CCR2 with a ligand thereof, and to use of the antibodies and fragments in therapeutic, prophylactic and diagnostic methods. | 03-21-2013 |
20150086546 | HUMANIZED ANTI-CCR2 ANTIBODIES AND METHODS OF USE THEREFOR - The present invention relates to a humanized antibody or functional fragment thereof which binds to a mammalian (e.g., human) CC-chemokine receptor 2 (CCR2) or a portion of the receptor and blocks binding of a ligand to the receptor. The invention further relates to a method of inhibiting the interaction of a cell bearing mammalian CCR2 with a ligand thereof, and to use of the antibodies and fragments in therapeutic, prophylactic and diagnostic methods. | 03-26-2015 |
Susan O'Brien, Salisbury GB
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20090186368 | Assay with reduced background - In an assay, an analyte in a sample is contacted with a thermostable reporter adenylate kinase coupled to a binding agent specific for the analyte, wherein a complex is formed. ADP is added, and then formation of ATP is monitored. Prior to the addition of ADP, endogenous kinase and uncomplexed thermostable reporter adenylate kinase is substantially removed by washing and residual endogenous kinase is inactivated by heating. Prior to contacting the analyte with the thermostable reporter adenylate kinase, the sample has a background activity of at least 300,000 Relative Light Units per mg protein per ml sample when measured in the presence of luciferin/luciferase by a luminometer. | 07-23-2009 |
Terence Kevin O'Brien, Cambridgeshire GB
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20110270047 | Monitoring Device and Method - A monitoring device arranged to display a level of consciousness and hemodynamic parameters of a patient for simultaneous viewing. A dependence of changes in the hemodynamic parameters of the patient on the level of consciousness of the patient may be more easily observed using the monitoring device. Correlations between the patient's level of consciousness and the patient's hemodynamic parameters may further be determined and displayed to aid clinicians in estimating any improvement in hemodynamic parameters that may be achieved through manipulation of the patient's level of consciousness, fluid status and drugs. | 11-03-2011 |
20140051051 | MONITORING DEVICE AND METHOD - A monitoring device arranged to display a level of consciousness and hemodynamic parameters of a patient for simultaneous viewing. A dependence of changes in the hemodynamic parameters of the patient on the level of consciousness of the patient may be more easily observed using the monitoring device. Correlations between the patient's level of consciousness and the patient's hemodynamic parameters may further be determined and displayed to aid clinicians in estimating any improvement in hemodynamic parameters that may be achieved through manipulation of the patient's level of consciousness, fluid status and drugs. | 02-20-2014 |
Terence Kevin O'Brien, Cambridge GB
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20130006126 | HEMODYNAMIC MONITOR AND METHOD OF HEMODYNAMIC MONITORING - An apparatus and method for determining stroke volume. The apparatus receives an arterial pressure waveform and is arranged to correct a part of the pressure waveform that relates to a heart beat for an influence of an ectopic heart beat, of atrial fibrillation on the pressure waveform or of changes in the pressure waveform's baseline. The apparatus also comprising means arranged to calculate the stroke volume from the corrected waveform. | 01-03-2013 |
20140121546 | DEVICE AND METHOD FOR THE CONTINUOUS NON-INVASIVE MEASUREMENT OF BLOOD PRESSURE - A device and method for use in monitoring blood pressure. The device comprises a controller configured to monitor a first blood pressure measurement based on a first blood pressure signal. The controller is configured to initiate acquiring a second blood pressure measurement based on a second blood pressure signal if the first blood pressure measurement exceeds a predetermined threshold. The decision to initiate acquiring the second blood pressure measurement is based on only one blood pressure measurement. | 05-01-2014 |
20150359435 | HEMODYNAMIC MONITORING - A device and method for use in monitoring blood pressure. The device comprises a controller configured to monitor a first blood pressure measurement based on a first blood pressure signal. The controller is configured to initiate acquiring a second blood pressure measurement based on a second blood pressure signal if the first blood pressure measurement exceeds a predetermined threshold. The decision to initiate acquiring the second blood pressure measurement is based on only one blood pressure measurement. | 12-17-2015 |
Terence Kevin O'Brien, London GB
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20090099424 | Patient Monitoring - A hemodynamic monitor and corresponding method for determining the requirement for, and if required the nature or extent of, and for monitoring the response to, an intervention by a carer for a subject in order to improve the hydration level and hemodynamic status of the subject during a period or periods of hemodynamic instability includes, firstly, a processor. The processor incorporates software arranged to continuously analyse and process a blood pressure or arterial volume/plethysmographic signal obtained from the subject in order to derive a plurality of complementary parameters throughout the monitoring of the subject. The monitor also incorporates display means displaying images representing the derived plurality of complementary parameters. The images include at least one image representing graphically at least one stress related hemodynamic parameter plotted against time to provide an immediate indication of a change in hemodynamic status and thus the requirement for an intervention. The images also include at least one image representing graphically at least one fluid responsiveness parameter plotted against time to provide an indication of the hydration level and associated ventricular pre load status of the subject to determine the nature or extent of the intervention if required. The images may also include at least one image representing graphically at least one response related parameter compared to the value of the parameter at the point of the intervention to provide an indication of the desired and/or actual response of the subject to an intervention. Trend and acute changes displays may be combined. Specific parameters providing information on the quality of the left ventricle and right heart/venous return/preload may also be derived and displayed. | 04-16-2009 |
20090131805 | Patient Monitoring - A hemodynamic monitor and corresponding method for determining the requirement for, and if required the nature or extent of, and for monitoring the response to, an intervention by a carer for a subject in order to improve the hydration level and hemodynamic status of the subject during a period or periods of hemodynamic instability includes, firstly, a processor. The processor incorporates software arranged to continuously analyse and process a blood pressure or arterial volume/plethysmographic signal obtained from the subject in order to derive a plurality of complementary parameters throughout the monitoring of the subject. The monitor also incorporates display means displaying images representing the derived plurality of complementary parameters. The images may include at least one image representing graphically at least one stress related hemodynamic parameter plotted against time to provide an immediate indication of a change in hemodynamic status and thus the requirement for an intervention. The images may also include at least one image representing graphically at least one fluid responsiveness parameter plotted against time to provide an indication of the hydration level and associated ventricular pre load status of the subject to determine the nature or extent of the intervention if required. Respiratory variations in fluid responsiveness parameters may usefully be displayed. The images may also include at least one image representing graphically at least one response related parameter compared to the value of the parameter at the point of the intervention to provide an indication of the desired and/or actual response of the subject to an intervention. Trend and acute changes displays may be combined. Specific parameters providing information on the quality of the left ventricle and right heart/venous return/preload may also be derived and displayed. | 05-21-2009 |
Thomas O'Brien, London GB
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20130230702 | ROOFING FELT MATERIAL - A roofing material includes a sheet of flexible material having two parallel long sides and two short end edges joining the long sides. The material has pre-printed thereon a plurality of longitudinal guide lines extending parallel to the long sides of the material. The guide lines are equally spaced and arranged in a repeating sequence across the width of the material to form identical groups of a plurality of guide lines. Each guide line of a group is visually distinct from the others in the group. The material further includes a plurality of different indicator markings, one indictor marking corresponding to each group of guide lines to enable each group of guide lines to be distinguished from the other groups. | 09-05-2013 |
Vincent O'Brien, Ayr GB
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20110312524 | METHODS EMPLOYING NON-CODING RNA EXPRESSION ASSAYS - There is disclosed a method comprising the steps of: carrying out a plurality of expression assays, each expression assay comprising the steps of: carrying out an intervention on a biological system, measuring an expression profile of non-coding RNAs in the biological system resulting from the intervention, and storing an expression data set derived from the measured expression profile, the said expression assays concerning either or both a plurality of different interventions and a plurality of different biological systems; and analysing the resulting expression data sets to determine correlations between the effect on the expression profile of non-coding RNAs of the respective intervention in groups of two or more expression assays concerning either or both different interventions or different biological systems. | 12-22-2011 |
20130196875 | CELL CHARACTERISATION - The present invention concerns the finding that non-coding RNA profiles can be exploited as a means of monitoring, assessing, comparing, establishing and/or determining certain cell characteristics and/or profiles. Accordingly, the invention provides the use of non-coding RNA molecules for characterising and/or profiling cells. | 08-01-2013 |
20160002722 | METHODS EMPLOYING NON-CODING RNA EXPRESSION ASSAYS - There is disclosed a method comprising the steps of: carrying out a plurality of expression assays, each expression assay comprising the steps of: carrying out an intervention on a biological system, measuring an expression profile of non-coding RNAs in the biological system resulting from the intervention, and storing an expression data set derived from the measured expression profile, the said expression assays concerning either or both a plurality of different interventions and a plurality of different biological systems; and analysing the resulting expression data sets to determine correlations between the effect on the expression profile of non-coding RNAs of the respective intervention in groups of two or more expression assays concerning either or both different interventions or different biological systems. | 01-07-2016 |