Patent application number | Description | Published |
20100265864 | Method and apparatus for power management in communication system - A method and apparatus for power management in the communication system, wherein the method for transmitting data from an access point to communication units comprising: assigning, by the access point, a first and a second association identifier in a message, to each of the communication units, to indicate the presence of respective buffered multicast data and unicast data respectively; setting, by the access point, the first association identifier to indicate the corresponding communication unit to receive the buffered multicast data, the second association identifier to indicate the corresponding communication unit to receive the buffered unicast data; and transmitting, by the access point, the message to awake the communication unit corresponding to the set first and/or second association identifier so as to transmit the buffered data thereto. | 10-21-2010 |
20110099449 | METHOD AND APPARATUS FOR FEC ENCODING AND DECODING - A method for Forward Error Correction (FEC) encoding in a transmitter, the method comprising: receiving a data stream from a data source; generating a first Forward Error Correction data for respective data block with a first block size of the data stream; and generating a second Forward Error Correction data for respective data block with a second block size of the data stream, wherein the second block size is different with the first block size and wherein the data blocks of the first block size form the data stream, and the data blocks with the second block size form the data stream. | 04-28-2011 |
20110228855 | Device for Encoding Video Data, Device for Decoding Video Data, Stream of Digital Data - The invention concerns a device for encoding video data, a device for decoding video data and a digital stream of video data. According to the invention, the encoding device comprises—means for encoding color information related to said video data according to one layer of a scalable model, —means for encoding transformation data enabling to obtain any level of said scalable model of color information from said one layer. | 09-22-2011 |
20120134446 | METHOD AND APPARATUS FOR RECEIVING DATA - Modem coding and modulation techniques have greatly improved the transmission and reception of signals. A method is described including receiving a signal de-mapping the signal into a first and second substream, decoding the first and second substream using a low density parity check decoding process, and combining the first and second decoded substream into a single data stream. An apparatus is described including a symbol de-mapper that receives a signal de-maps the modulation symbols in the signal into a first and second substream, a first decoder that decodes the first substream using a low density parity check coding process at a first decoding rate, a second decoder that decodes the second substream at a second encoding rate, and a combiner that combines the first substream and the second substream into a single data stream. | 05-31-2012 |
20120253814 | SYSTEM AND METHOD FOR WEB TEXT CONTENT AGGREGATION AND PRESENTATION - A system and method for aggregating text-based content and presenting the text-based content as spoken audio is described herein, where a server module retrieves and aggregates web content from web content providers that may include text-based web content that is then extracted, filtered and categorizes for a client module to retrieve and play as spoken audio. | 10-04-2012 |
Patent application number | Description | Published |
20100285059 | Cytomegalovirus Vaccines and Methods of Production - Methods of increasing diversity in cytomegalovirus vaccines through the selection of cell type in which the virus is propagated, and the use of cytomegalovirus produced by those methods in the development of vaccine compositions, are disclosed. Vaccine compositions comprising CMV isolated from epithelial cells are also disclosed. | 11-11-2010 |
20110200633 | Cytomegalovirus Surface Protein Complex for Use in Vaccines and as a Drug Target - Immunogenic compositions and prophylactic or therapeutic vaccines for use in protecting and treating against human cytomegalovirus (CMV) are disclosed. Subunit vaccines comprising a human CMV protein complex comprising pUL128 or pUL130, and nucleic acid vaccines comprising at least one nucleic acid encoding a CMV protein complex comprising pUL128 or pUL130 are described. Also disclosed are therapeutic antibodies reactive against a CMV protein complex comprising pUL128 or pUL130, as well as methods for screening compounds that inhibit CMV infection of epithelial and endothelial cells, methods for immunizing a subject against CMV infection, methods for determining the capability of neutralizing antibodies to inhibit CMV infection of cell types other than fibroblasts, and methods of diminishing an CMV infection. | 08-18-2011 |
20120226023 | CYTOMEGALOVIRUS SURFACE PROTEIN COMPLEX FOR USE IN VACCINES AND AS A DRUG TARGET - Immunogenic compositions and prophylactic or therapeutic vaccines for use in protecting and treating against human cytomegalovirus (CMV) are disclosed. Subunit vaccines comprising a human CMV protein complex comprising pUL128 or pUL130, and nucleic acid vaccines comprising at least one nucleic acid encoding a CMV protein complex comprising pUL128 or pUL130 are described. Also disclosed are therapeutic antibodies reactive against a CMV protein complex comprising pUL128 or pUL130, as well as methods for screening compounds that inhibit CMV infection of epithelial and endothelial cells, methods for immunizing a subject against CMV infection, methods for determining the capability of neutralizing antibodies to inhibit CMV infection of cell types other than fibroblasts, and methods of diminishing an CMV infection. | 09-06-2012 |
20140220062 | CONDITIONAL REPLICATING CYTOMEGALOVIRUS AS A VACCINE FOR CMV - The present invention relates to methods of inducing an immune response to cytomegalovirus (CMV) using a genetically modified CMV that is conditionally replication defective. The methods of the invention can be used to treat and/or prevent primary CMV infection, infection due to reactivation of a latent CMV and a super-infection of a different strain of CMV that had been previously encountered. The present invention also relates to a replication defective CMV which has been recombinantly altered to allow for external control of viral replication. Compositions comprising the replication defective CMV are also encompassed by the present invention. | 08-07-2014 |
20140370026 | Cytomegalovirus Surface Protein Complex For Use in Vaccines and as a Drug Target - Immunogenic compositions and prophylactic or therapeutic vaccines for use in protecting and treating against human cytomegalovirus (CMV) are disclosed. Subunit vaccines comprising a human CMV protein complex comprising pUL128 or pUL130, and nucleic acid vaccines comprising at least one nucleic acid encoding a CMV protein complex comprising pUL128 or pUL130 are described. Also disclosed are therapeutic antibodies reactive against a CMV protein complex comprising pULl28or pUL130, as well as methods for screening compounds that inhibit CMV infection of epithelial and endothelial cells, methods for immunizing a subject against CMV infection, methods for determining the capability of neutralizing antibodies to inhibit CMV infection of cell types other than fibroblasts, and methods of diminishing an CMV infection. | 12-18-2014 |
Patent application number | Description | Published |
20110045347 | Self Assembled Multi-Layer Nanocomposite of Graphene and Metal Oxide Materials - Nanocomposite materials having at least two layers, each layer consisting of one metal oxide bonded to at least one graphene layer were developed. The nanocomposite materials will typically have many alternating layers of metal oxides and graphene layers, bonded in a sandwich type construction and will be incorporated into an electrochemical or energy storage device. | 02-24-2011 |
20110051316 | Mesoporous Metal Oxide Graphene Nanocomposite Materials - A nanocomposite material formed of graphene and a mesoporous metal oxide having a demonstrated specific capacity of more than 200 F/g with particular utility when employed in supercapacitor applications. A method for making these nanocomposite materials by first forming a mixture of graphene, a surfactant, and a metal oxide precursor, precipitating the metal oxide precursor with the surfactant from the mixture to form a mesoporous metal oxide. The mesoporous metal oxide is then deposited onto a surface of the graphene. | 03-03-2011 |
20110111299 | LITHIUM ION BATTERIES WITH TITANIA/GRAPHENE ANODES - Lithium ion batteries having an anode comprising at least one graphene layer in electrical communication with titania to form a nanocomposite material, a cathode comprising a lithium olivine structure, and an electrolyte. The graphene layer has a carbon to oxygen ratio of between 15 to 1 and 500 to 1 and a surface area of between 400 and 2630 m | 05-12-2011 |
20120207994 | CARBON-METAL OXIDE-SULFUR CATHODES FOR HIGH-PERFORMANCE LITHIUM-SULFUR BATTERIES - Embodiments presented herein provide a new approach for high-performance lithium-sulfur battery by using novel carbon-metal oxide-sulfur composites. The composites may be prepared by encapsulating sulfur particles in bifunctional carbon-supported metal oxide or other porous carbon-metal oxide composites. In this way, the porous carbon-metal oxide composite confines sulfur particles within its tunnels and maintain the electrical contact during cycling. Furthermore, the uniformly embedded metal oxides in the structure strongly adsorb polysulfide intermediates, avoid dissolution loss of sulfur, and ensure high coulombic efficiency as well as a long cycle life. | 08-16-2012 |
20120295027 | MESOPOROUS METAL OXIDE GRAPHENE NANOCOMPOSITE MATERIALS - A nanocomposite material formed of graphene and a mesoporous metal oxide having a demonstrated specific capacity of more than 200 F/g with particular utility when employed in supercapacitor applications. A method for making these nanocomposite materials by first forming a mixture of graphene, a surfactant, and a metal oxide precursor, precipitating the metal oxide precursor with the surfactant from the mixture to form a mesoporous metal oxide. The mesoporous metal oxide is then deposited onto a surface of the graphene. | 11-22-2012 |
20140017569 | DOPED CARBON-SULFUR SPECIES NANOCOMPOSITE CATHODE FOR LI-S BATTERIES - We report a heteroatom-doped carbon framework that acts both as conductive network and polysulfide immobilizer for lithium-sulfur cathodes. The doped carbon forms chemical bonding with elemental sulfur and/or sulfur compound. This can significantly inhibit the diffusion of lithium polysulfides in the electrolyte, leading to high capacity retention and high coulombic efficiency. | 01-16-2014 |
20140030181 | NANOCOMPOSITE OF GRAPHENE AND METAL OXIDE MATERIALS - Nanocomposite materials comprising a metal oxide bonded to at least one graphene material. The nanocomposite materials exhibit a specific capacity of at least twice that of the metal oxide material without the graphene at a charge/discharge rate greater than about 10 C. | 01-30-2014 |
20140106219 | Synthesis of Micro-Sized Interconnected Si-C Composites - Embodiments provide a method of producing micro-sized Si—C composites or doped Si—C and Si alloy-C with interconnected nanoscle Si and C building blocks through converting commercially available SiO | 04-17-2014 |
20140170459 | Liquid Electrolyte for Increasing Capacity and Cycling Retention of Lithium Sulfur Battery - We provide a liquid electrolyte for a lithium-sulfur battery. Electrolytes of the invention may include a protecting additive; a lithium salt (in addition to LiNO | 06-19-2014 |
20140272591 | LITHIUM ION BATTERY ANODES INCLUDING GRAPHENIC CARBON PARTICLES - Lithium ion battery anodes including graphenic carbon particles are disclosed. Lithium ion batteries containing such anodes are also disclosed. The anodes include mixtures of lithium-reactive metal particles such as silicon, graphenic carbon particles, and a binder. The use of graphenic carbon particles in the anodes results in improved performance of the lithium ion batteries. | 09-18-2014 |
20150017569 | MESOPOROUS SILICON SYNTHESIS AND APPLICATIONS IN LI-ION BATTERIES AND SOLAR HYDROGEN FUEL CELLS - We provide a mesoporous silicon material (PSi) prepared via a template-free and HF-free process. The production process is facile and scalable, and it may be conducted under mild reaction conditions. The silicon may be produced directly by the reduction of a silicon-halogenide precursor (for example, SiCl | 01-15-2015 |
Patent application number | Description | Published |
20090104210 | Peptide compounds for treating obesity and insulin resistance - Compounds comprising an angiopoietin-like protein 6 (Angptl6) peptide for use in the treatment of metabolic syndrome, in particular, obesity and insulin resistance are described. | 04-23-2009 |
20100166772 | ANTIGEN-BINDING PROTEINS TARGETING S. AUREUS ORF0657n - The present invention features antigen binding proteins that bind to a region found to have an epitope that can be targeted to provide protection against | 07-01-2010 |
20110286916 | GENERATION AND CHARACTERIZATION OF ANTI-NOTCH ANTIBODIES FOR THERAPEUTIC AND DIAGNOSTIC USE - The present invention relates to mammalian antibodies, preferably fully human monoclonal antibodies and antigen-binding portions thereof that specifically bind to a cell surface receptor, wherein the receptor protein is a Notch1 receptor protein. Some of the disclosed antibodies bind Notch1 to the exclusion of other members of the Notch receptor family, while other antibodies bind Notch 1 and Notch3. Nucleic acid molecules encoding the Notch antibodies as well as methods of use thereof are also disclosed. Also included are pharmaceutical compositions comprising these antibodies and methods of using the antibodies and compositions thereof for treatment and diagnosis of pathological hyperproliferative oncogenic disorders associated with expression of Notch1 or Notch3 including aberrant activation of each of these receptors. | 11-24-2011 |
20120201835 | ANTIBODIES SPECIFIC FOR DKK-1 - Antibodies specific for Dkk-1, an inhibitor of the osteoanabolic Wnt/LRP5 signaling pathway, are described. The antibodies, which inhibit binding of Dkk-1 to LRP5, are useful in compositions for stimulating bone growth, in particular, compositions for treating bone disorders which result in a loss in bone, for example, osteoporosis. | 08-09-2012 |
20130089537 | METHOD FOR TREATING A DISEASE ASSOCIATED WITH SOLUBLE, OLIGOMERIC SPECIES OF AMYLOID BETA 1-42 - This invention is a method and kit for treating a disease associated with, or resulting from, the accumulation of soluble oligomer amyloid beta 1-42 using an antibody, or antibody fragment thereof, that has a higher affinity for amyloid beta 1-42 oligomers than for amyloid beta 1-42 monomer, amyloid beta 1-40 monomer, plaques and amyloid beta fibrils and, optionally, a tau therapeutic or an inhibitor of amyloid beta production or aggregation. | 04-11-2013 |
20130115227 | ANTI-ADDL MONOCLONAL ANTIBODY AND USES THEREOF - Disclosed are antibodies that bind amyloid beta-derived diffusible ligands, also known as ADDLs. The antibodies are selective for ADDLs, can penetrate the brain, and are useful in methods of detecting ADDLs and diagnosing Alzheimer's disease. The antibodies also block binding of ADDLs to neurons, assembly of ADDLS, and tau phosphorylation and are there useful in methods for the preventing and treating diseases associated with ADDLs. | 05-09-2013 |
20130130288 | Antibodies, Kit and Method for Detecting Amyloid Beta Oligomers - This invention is a selective Aβ oligomer kit and immunoassay method capable of reliably and sensitively detecting Aβ oligomers in a biological sample of a patient. In one embodiment the inventive assay uses a pair of anti-Aβ oligomer antibodies, as capture and detection antibodies, to detect and quantify Aβ oligomers. The method can be used to differentiate Alzheimer's disease (AD) patients from non-AD patients and/or to stratify AD patients according to the severity of their disease. | 05-23-2013 |
20150023952 | ANTI-ADDL MONOCLONAL ANTIBODY AND USES THEREOF - The present invention relates to antibodies that bind amyloid β-derived diffusible ligands, also known as ADDLs. The antibodies of the invention are selective for ADDLs, can penetrate the brain, and are useful in methods of detecting ADDLs and diagnosing Alzheimer's disease. The present antibodies also block binding of ADDLs to neurons, assembly of ADDLS, and tau phosphorylation and are there useful in methods for the preventing and treating diseases associated with ADDLs. | 01-22-2015 |
Patent application number | Description | Published |
20080285860 | STUDYING AESTHETICS IN PHOTOGRAPHIC IMAGES USING A COMPUTATIONAL APPROACH - The aesthetic quality of a picture is automatically inferred using visual content as a machine learning problem using, for example, a peer-rated, on-line photo sharing Website as data source. Certain visual features of images are extracted based on the intuition that they can discriminate between aesthetically pleasing and displeasing images. A one-dimensional support vector machine is used to identify features that have noticeable correlation with the community-based aesthetics ratings. Automated classifiers are constructed using the support vector machines and classification trees, with a simple feature selection heuristic being applied to eliminate irrelevant features. Linear regression on polynomial terms of the features is also applied to infer numerical aesthetics ratings. | 11-20-2008 |
20090083332 | TAGGING OVER TIME: REAL-WORLD IMAGE ANNOTATION BY LIGHTWEIGHT METALEARNING - A principled, probabilistic approach to meta-learning acts as a go-between for a ‘black-box’ image annotation system and its users. Inspired by inductive transfer, the approach harnesses available information, including the black-box model's performance, the image representations, and a semantic lexicon ontology. Being computationally ‘lightweight.’ the meta-learner efficiently re-trains over time, to improve and/or adapt to changes. The black-box annotation model is not required to be re-trained, allowing computationally intensive algorithms to be used. Both batch and online annotation settings are accommodated. A “tagging over time” approach produces progressively better annotation, significantly outperforming the black-box as well as the static form of the meta-learner, on real-world data. | 03-26-2009 |
20090204637 | REAL-TIME COMPUTERIZED ANNOTATION OF PICTURES - A computerized annotation method achieves real-time operation and better optimization properties while preserving the architectural advantages of the generative modeling approach. A novel clustering algorithm for objects is represented by discrete distributions, or bags of weighted vectors, thereby minimizing the total within cluster distance, a criterion used by the k-means algorithm. A new mixture modeling method, the hypothetical local mapping (HLM) method, is used to efficiently build a probability measure on the space of discrete distributions. Thus, in accord with the invention every image is characterized by a statistical distribution. The profiling model specifies a probability law for distributions directly. | 08-13-2009 |
20120268612 | ON-SITE COMPOSITION AND AESTHETICS FEEDBACK THROUGH EXEMPLARS FOR PHOTOGRAPHERS - A comprehensive system to enhance the aesthetic quality of the photographs captured by mobile consumers provides on-site composition and aesthetics feedback through retrieved examples. Composition feedback is qualitative in nature and responds by retrieving highly aesthetic exemplar images from the corpus which are similar in content and composition to the snapshot. Color combination feedback provides confidence on the snapshot to contain good color combinations. Overall aesthetics feedback predicts the aesthetic ratings for both color and monochromatic images. An algorithm is used to provide ratings for color images, while new features and a new model are developed to treat monochromatic images. This system was designed keeping the next generation photography needs in mind and is the first of its kind. The feedback rendered is guiding and intuitive in nature. It is computed in situ while requiring minimal input from the user. | 10-25-2012 |
20130011070 | STUDYING AESTHETICS IN PHOTOGRAPHIC IMAGES USING A COMPUTATIONAL APPROACH - The aesthetic quality of a picture is automatically inferred using visual content as a machine learning problem using, for example, a peer-rated, on-line photo sharing Website as data source. Certain visual features of images are extracted based on the intuition that they can discriminate between aesthetically pleasing and displeasing images. A one-dimensional support vector machine is used to identify features that have noticeable correlation with the community-based aesthetics ratings. Automated classifiers are constructed using the support vector machines and classification trees, with a simple feature selection heuristic being applied to eliminate irrelevant features. Linear regression on polynomial terms of the features is also applied to infer numerical aesthetics ratings. | 01-10-2013 |
20140049546 | AUTOMATICALLY COMPUTING EMOTIONS AROUSED FROM IMAGES THROUGH SHAPE MODELING - Shape features in natural images influence emotions aroused in human beings. An in-depth statistical analysis helps to understand the relationship between shapes and emotions. Through experimental results on the International Affective Picture System (IAPS) dataset, evidence is presented as to the significance of roundness-angularity and simplicity-complexity on predicting emotional content in images. Shape features are combined with other state-of-the-art features to show a gain in prediction and classification accuracy. Emotions are modeled from a dimensional perspective in order to predict valence and arousal ratings, which have advantages over modeling the traditional discrete emotional categories. Images are distinguished vis-a-vis strong emotional content from emotionally neutral images with high accuracy. | 02-20-2014 |
20140143251 | MASSIVE CLUSTERING OF DISCRETE DISTRIBUTIONS - The trend of analyzing big data in artificial intelligence requires more scalable machine learning algorithms, among which clustering is a fundamental and arguably the most widely applied method. To extend the applications of regular vector-based clustering algorithms, the Discrete Distribution (D2) clustering algorithm has been developed for clustering bags of weighted vectors which are well adopted in many emerging machine learning applications. The high computational complexity of D2-clustering limits its impact in solving massive learning problems. Here we present a parallel D2-clustering algorithm with substantially improved scalability. We develop a hierarchical structure for parallel computing in order to achieve a balance between the individual-node computation and the integration process of the algorithm. The parallel algorithm achieves significant speed-up with minor accuracy loss. | 05-22-2014 |
20140307958 | INSTANCE-WEIGHTED MIXTURE MODELING TO ENHANCE TRAINING COLLECTIONS FOR IMAGE ANNOTATION - Automatic selection of training images is enhanced using an instance-weighted mixture modeling framework called ARTEMIS. An optimization algorithm is derived that in addition to mixture parameter estimation learns instance-weights, essentially adapting to the noise associated with each example. The mechanism of hypothetical local mapping is evoked so that data in diverse mathematical forms or modalities can be cohesively treated as the system maintains tractability in optimization. Training examples are selected from top-ranked images of a likelihood-based image ranking. Experiments indicate that ARTEMIS exhibits higher resilience to noise than several baselines for large training data collection. The performance of ARTEMIS-trained image annotation system is comparable to using manually curated datasets. | 10-16-2014 |
20140363085 | On-site composition and aesthetics feedback through exemplars for photographers - A comprehensive system to enhance the aesthetic quality of the photographs captured by mobile consumers provides on-site composition and aesthetics feedback through retrieved examples. Composition feedback is qualitative in nature and responds by retrieving highly aesthetic exemplar images from the corpus which are similar in content and composition to the snapshot. Color combination feedback provides confidence on the snapshot to contain good color combinations. Overall aesthetics feedback predicts the aesthetic ratings for both color and monochromatic images. An algorithm is used to provide ratings for color images, while new features and a new model are developed to treat monochromatic images. This system was designed keeping the next generation photography needs in mind and is the first of its kind. The feedback rendered is guiding and intuitive in nature. It is computed in situ while requiring minimal input from the user. | 12-11-2014 |
Patent application number | Description | Published |
20090275515 | 2-HYDROXY-2-PHENYLTHIOPHENYLPROPIONAMIDES AS ANDROGEN RECEPTOR MODULATORS - Compounds of structural formula (I) are modulators of the androgen receptor (AR) in a tissue selective manner. These compounds are useful in the enhancement of weakened muscle tone and the treatment of conditions caused by androgen deficiency or which can be ameliorated by androgen administration, including osteoporosis, osteopenia, glucocorticoid-induced osteoporosis, periodontal disease, bone fracture, bone damage following bone reconstructive surgery, sarcopenia, frailty, aging skin, male hypogonadism, postmenopausal symptoms in women, atherosclerosis, hypercholesterolemia, hyperlipidemia, obesity, aplastic anemia and other hematopoietic disorders, inflammatory arthritis and joint repair, HFV-wasting, prostate cancer, benign prostatic hyperplasia (BPH), abdominal adiposity, metabolic syndrome, type II diabetes, cancer cachexia, Alzheimer's disease, muscular dystrophies, cognitive decline, sexual dysfunction, sleep apnea, depression, premature ovarian failure, and autoimmune disease, alone or in combination with other active agents. | 11-05-2009 |
20100222321 | Inhibitors of akt activtiy - The instant invention provides for substituted naphthyridine compounds that inhibit Akt activity. In particular, the compounds disclosed selectively inhibit one or two of the Akt isoforms. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting Akt activity by administering the compound to a patient in need of treatment of cancer. | 09-02-2010 |
20110082135 | INHIBITORS OF AKT ACTIVITY - The instant invention provides for substituted [1,2,4]triazolo[4,3-a]-1,5-naphthyridine compounds that inhibit Akt activity. In particular, the compounds disclosed selectively inhibit one or two of the Akt isoforms, preferably Akt1. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting Akt activity, especially Akt1 by administering the compound to a patient in need of treatment of cancer. | 04-07-2011 |
20110092511 | INHIBITORS OF AKT ACTIVITY - The instant invention provides for substituted naphthyridine compounds that inhibit Akt activity. In particular, the compounds disclosed selectively inhibit one or two of the Akt isoforms, preferably Akt1. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting Akt activity especially Akt1 by administering the compound to a patient in need of treatment of cancer. | 04-21-2011 |
20110288090 | Inhibitors of AKT Activity - The instant invention provides for compounds that inhibit Akt activity. In particular, the compounds disclosed selectively inhibit one or two of the Akt isoforms. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting Akt activity by administering the compound to a patient in need of treatment of cancer. | 11-24-2011 |
20120077810 | Inhibitors Of AKT Activity - The instant invention provides for substituted fused pyrimidine compounds that inhibit Akt activity. In particular, the compounds disclosed selectively inhibit one or two of the Akt isoforms. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting Akt activity by administering the compound to a patient in need of treatment of cancer. | 03-29-2012 |
Patent application number | Description | Published |
20110065762 | METHODS OF USE OF ANTIVIRAL COMPOUNDS - The present invention relates, in part, to methods of treatment, prevention, and inhibition of viral disorders. In one aspect, the present invention relates to inhibition of the M2 proton channel of influenza viruses (e.g. influenza A virus) and other similar viroporins (e.g., VP24 of Ebola and Marburg viruses; and NS3 protein of Bluetongue). The present invention further relates, inter alia, to compounds which have been shown to possess antiviral activity, in particular, inhibiting the M2 proton channel of influenza viruses. | 03-17-2011 |
20110065766 | METHODS OF USE OF ANTIVIRAL COMPOUNDS - The present invention relates, in part, to methods of treatment, prevention, and inhibition of viral disorders. In one aspect, the present invention relates to inhibition of the M2 proton channel of influenza viruses (e.g. influenza A virus) and other similar viroporins (e.g., VP24 of Ebola and Marburg viruses; and NS3 protein of Bluetongue). The present invention further relates, inter alia, to compounds which have been shown to possess antiviral activity, in particular, inhibiting the M2 proton channel of influenza viruses. | 03-17-2011 |
20120295886 | ANTIVIRAL COMPOUNDS AND THEIR METHODS OF USE - The present disclosure provides compounds having affinity for the M2 proton channel, useful for the treatment of viral infections such as influenza, which are of the Formula (I): | 11-22-2012 |
Patent application number | Description | Published |
20090232795 | 1B20 PCSK9 ANTAGONISTS - Antagonists of human proprotein convertase subtilisin-kexin type 9 (“PCSK9”) are disclosed. The disclosed antagonists are effective in the inhibition of PCSK9 function and, accordingly, present desirable antagonists for use in the treatment of conditions associated with PCSK9 activity. The present invention also discloses nucleic acid encoding said antagonists, vectors, host cells, and compositions comprising the antagonists. Methods of making PCSK9-specific antagonists as well as methods of using the antagonists for inhibiting or antagonizing PCSK9 function are also disclosed and form important additional aspects of the present disclosure. | 09-17-2009 |
20090246192 | 1D05 PCSK9 antagonists - Antagonists of human proprotein convertase subtilisin-kexin type 9 (“PCSK9”) are disclosed. The disclosed antagonists are effective in the inhibition of PCSK9 function and, accordingly, present desirable antagonists for use in the treatment of conditions associated with PCSK9 activity. The present invention also discloses nucleic acid encoding said antagonists, vectors, host cells, and compositions comprising the antagonists. Methods of making PCSK9-specific antagonists as well as methods of using the antagonists for inhibiting or antagonizing PCSK9 function are also disclosed and form important additional aspects of the present disclosure. | 10-01-2009 |
20120301461 | 1D05 PCSK9 ANTAGONISTS - Antagonists of human proprotein convertase subtilisin-kexin type 9 (“PCSK9”) are disclosed. The disclosed antagonists are effective in the inhibition of PCSK9 function and, accordingly, present desirable antagonists for use in the treatment of conditions associated with PCSK9 activity. The present invention also discloses nucleic acid encoding said antagonists, vectors, host cells, and compositions comprising the antagonists. Methods of making PCSK9-specific antagonists as well as methods of using the antagonists for inhibiting or antagonizing PCSK9 function are also disclosed and form important additional aspects of the present disclosure. | 11-29-2012 |
20130071379 | 1B20 PCSK9 ANTAGONISTS - Antagonists of human proprotein convertase subtilisin-kexin type 9 (“PCSK9”) are disclosed. The disclosed antagonists are effective in the inhibition of PCSK9 function and, accordingly, present desirable antagonists for use in the treatment of conditions associated with PCSK9 activity. The present invention also discloses nucleic acid encoding said antagonists, vectors, host cells, and compositions comprising the antagonists. Methods of making PCSK9-specific antagonists as well as methods of using the antagonists for inhibiting or antagonizing PCSK9 function are also disclosed and form important additional aspects of the present disclosure. | 03-21-2013 |
Patent application number | Description | Published |
20090082221 | Cross-Species and Multi-Species Display Systems - The present invention provides expression vectors and helper display vectors which can be used in various combinations as vector sets for multi-species and cross-species display of polypeptides on the outer surface of prokaryotic genetic packages and/or eukaryotic host cells. The multi-species and cross-species display systems can be practiced using the vector sets of the invention without having to change or reengineer the display vectors. The display systems of the invention are particularly useful for displaying a genetically diverse repertoire or library of polypeptides on the surface of phage, bacterial host cells, yeast cells, and mammalian cells. | 03-26-2009 |
20090136523 | ANTI-CD26 ANTIBODIES AND METHODS OF USE THEREOF - The present invention provides novel anti-CD26 antibodies and other, related polypeptides, as well as novel polynucleotides encoding the antibodies and polypeptides. The invention also provides methods of making the antibodies and polypeptides. Compositions and cells comprising the antibodies or polypeptides are further provided. Methods of using the antibodies and/or polypeptides, such as to inhibit cell proliferation and in the treatment of conditions associated with CD26, are also provided. | 05-28-2009 |
20090163379 | Eukaryotic cell display systems - The present invention provides expression vectors and helper display vectors which can be used in various combinations as vector sets for display of polypeptides on the outer surface of eukaryotic host cells. The expression vector of the invention can be used alone for soluble expression without having to change or reengineer the display vectors. The display systems of the invention are particularly useful for displaying a genetically diverse repertoire or library of polypeptides on the surface of yeast cells, and mammalian cells. | 06-25-2009 |
20110171729 | Method for Producing Stable Mammalian Cell Lines Producing High Levels of Recombinant Proteins - The invention provides a novel method for generating stable mammalian cell lines with enhanced protein production capabilities, and to expression vectors and related methods for high level expression of biopharmaceutical proteins of interest. | 07-14-2011 |
20120231005 | AX1 AND AX189 PSCK9 ANTAGONISTS AND VARIANTS - Antagonists of human proprotein convertase subtilisin-kexin type 9 (“PCSK9”) are disclosed. The disclosed antagonists are effective in the inhibition of PCSK9 function and, accordingly, present desirable antagonists for use in the treatment of conditions associated with PCSK9 activity. The present invention also discloses nucleic acid encoding said antagonists, vectors, host cells, and compositions comprising the antagonists. Methods of making PCSK9-specific antagonists as well as methods of using the antagonists for inhibiting or antagonizing PCSK9 function are also disclosed and form important additional aspects of the present disclosure. | 09-13-2012 |
20120329679 | EUKARYOTIC CELL DISPLAY SYSTEMS - The present invention provides expression vectors and helper display vectors which can be used in various combinations as vector sets for display of polypeptides on the outer surface of eukaryotic host cells. The expression vector of the invention can be used alone for soluble expression without having to change or reengineer the display vectors. The display systems of the invention are particularly useful for displaying a genetically diverse repertoire or library of polypeptides on the surface of yeast cells, and mammalian cells. | 12-27-2012 |
Patent application number | Description | Published |
20090252689 | Hair styling composition - There is provided a hair styling composition comprising
| 10-08-2009 |
20120027711 | FIXATIVE POLYMER COMPATIABLE WITH HAIR STYLING COMPOSITION - A polymer with good compatibility comprising one or more non-ionic water soluble monomers, such as poly(ethylene glycol)(meth)acrylate (PEGMA), is provided that is suitable for use in aerosol hair styling formulations which have improved clarity. There is also provided a hair styling composition comprising (a) one or more fully soluble polymer, and (b) a solvent mixture, and optional other ingredients. | 02-02-2012 |
20120039819 | HAIR STYLING COMPOSITIONS WIYH IMPROVED CLARITY AND HUMIDITY RESISTANCE - The present invention provides a hair styling composition comprising (a) 1% to 10% by weight of at least one polymer comprising, as polymerized units, one or more monomers having at least one acid-functional group; (b) 99% to 90% by weight of a solvent mixture comprising: (i) 5% to 100% by weight of at least one volatile organic solvent; (ii) 95% to 0% by weight of water, and (iii) 0% to 80% by weight of at least one propellant; and (c) a neutralizer, wherein the mole ratio of said neutralizer to the acid-functional groups on said polymer (a) is from 0:1 to 1.2:1, and the neutralizer comprises: (i) 10% to 30% neutralization of the acid group of the polymer by tetrabutylammonium hydroxide, and (ii) 90% to 70% neutralization of the acid group of the polymer by aminomethyl propanol. More particularly, the polymer (a) may comprise, as polymerized units, (i) 30% to 75% by weight of one or more monomer that has refractive index of 1.490 or higher, (ii) 1% to 30% by weight of one or more acid-functional monomer, and (iii) 5% to 69% by weight of one or more additional monomer. The hair styling composition of the present invention has improved clarity and humidity resistance. | 02-16-2012 |
20120240953 | HAIR STYLING COMPOSITION - A method for styling hair comprising the steps of placing said hair in a desired configuration and applying a composition to said hair, said composition comprising
| 09-27-2012 |
20130195788 | HAIR FIXATIVES - Described are hair fixative compositions comprising an aqueous dispersion comprising an ethylene acrylic acid co-polymer, and optionally a metallocene catalyzed polyolefin. | 08-01-2013 |
20130259812 | CATIONIC POLYMER LATEXES AND USES - Described are novel polymers and home and personal care compositions incorporating said polymers. | 10-03-2013 |
20140017186 | SUNCARE COMPOSITIONS AND METHODS - Described are suncare compositions comprising (a) one or more fully soluble polymer comprising, as polymerized units, (i) 30% to 75% by weight, based on the weight of said polymer, one or more monomer that has refractive index of 1.490 or higher, (ii) 1% to 30% by weight, based on the weight of said polymer, one or more acid-functional monomer, and (iii) 5% to 69% by weight, based on the weight of said polymer, one or more additional monomer, and (b) at least one suncare active. | 01-16-2014 |
20140199250 | PERSONAL CARE COMPOSITION AND METHODS CONTAINING HYDROPHOBICALLY-MODIFIED HYDROXYETHYLCELLULOSE - Described are personal care compositions, comprising water, nonionic cellulose ethers having hydroxyethyl groups and being further substituted with one or more hydrophobic substituents, and at least one hair fixative polymer, moisturizer, conditioner, humectant, cationic conditioning polymer, antioxidant, anti-aging active, or sun care active. | 07-17-2014 |
20140202485 | PERSONAL CARE COMPOSITION AND METHODS INCORPORATING LOW GELATION TEMPERATURE METHYLCELLULOSE - Described are personal care compositions, comprising water, a methylcellulose that gels at 45C or less, and at least one one hair fixative polymer, moisturizer, conditioner, humectant, cationic conditioning polymer, anti-aging active, or sun care active. | 07-24-2014 |
Patent application number | Description | Published |
20100275732 | SYSTEMS, METHOD AND APPARATUS FOR REDUCING IMPURITIES IN ELECTROLYSIS CELLS - Systems, methods and apparatus for reducing impurities in electrolysis cells are disclosed. In one approach, a method includes feeding a particulate fines feed stream to a tank, mixing particulate fines (PF) with liquid, the liquid having a first liquid and a second liquid, and separating at least some of the first liquid from at least some of the second liquid. The particulate fines (PF) may include inlet carbon fines (CF | 11-04-2010 |
20120197542 | SYSTEMS AND METHODS FOR DETERMINING ALUMINA PROPERTIES - Systems, methods and apparatus relating to evaluation of alumina feedstocks are disclosed. A system may include an alumina storage unit comprising an alumina feedstock, an alumina supply member in communication with the alumina storage unit and an aluminum electrolysis cell. The alumina feedstock of the alumina storage unit may periodically flow through the alumina supply member and to the aluminum electrolysis cell. A measurement device may be in communication with the alumina supply member, and may be configured to measure a supply member property and transmit a first signal to a processor. The processor may be configured to receive the first signal and produce supply member property data based, at least in part, on the first signal. | 08-02-2012 |
20120228127 | SYSTEMS, METHOD AND APPARATUS FOR REDUCING IMPURITIES IN ELECTROLYSIS CELLS - Systems, methods and apparatus for reducing impurities in electrolysis cells are disclosed. In one approach, a method includes feeding a particulate fines feed stream to a tank, mixing particulate fines (PF) with liquid, the liquid having a first liquid and a second liquid, and separating at least some of the first liquid from at least some of the second liquid. The particulate fines (PF) may include inlet carbon fines (CF | 09-13-2012 |
Patent application number | Description | Published |
20080243982 | Hardware matrix computation for wireless receivers - In one embodiment, a receiver including one or more signal-processing blocks and a hardware-based matrix co-processor. The one or more signal-processing blocks are adapted to generate a processed signal from a received signal. The hardware-based matrix co-processor includes two or more different matrix-computation engines, each adapted to perform a different matrix computation, and one or more shared hardware-computation units, each adapted to perform a mathematical operation. At least one signal-processing block is adapted to offload matrix-based signal processing to the hardware-based matrix co-processor. Each of the two or more different matrix-computation engines is adapted to offload the same type of mathematical processing to at least one of the one or more shared hardware-computation units. | 10-02-2008 |
20100125777 | METHOD AND APPARATUS FOR PERFORMING A CRC CHECK - A description is given of an apparatus that includes a division unit configured to receive a data stream and to divide the received data stream into a plurality of data segments and a plurality of first CRC check units, wherein each of the first CRC units is configured to perform a CRC check of a respective one of the plurality of segments of data, and wherein the plurality of CRC checks are performed concurrently. | 05-20-2010 |
20100184420 | Method and Apparatus for Prolonging Battery Life in a Mobile Communication Device Using Motion Detection - A telecommunication device is equipped with circuitry that can detect phenomena indicative or predictive of motion of the telecommunications device, such as GPS circuitry. When the circuitry determines that the telecommunication device is stationary, it controls the device to perform neighboring cell polling at relatively large intervals or not at all. However, when the circuitry determines that the telecommunication device is moving, it controls the device to poll neighboring cells more frequently. | 07-22-2010 |
20110124352 | Method and Apparatus for Prolonging Battery Charge Life in a Mobile Communication Device Using a Text Messaging Type Protocol for Calls - A wireless telecommunication device conducts base station pages at large intervals, such as 30 seconds, rather than the more conventional 0.5 to 4 seconds. The network processes calls placed to that telecommunication device in accordance with an SMS (Short Messaging Service) type protocol rather than a conventional voice call protocol. Particularly, the network sends an SMS to the telephone indicating that a third party is calling (hereinafter termed a “pre-call SMS”). The pre-call SMS indicates the telephone number of the third party. The user of the telephone may call the third party back. In accordance with this protocol, the need to page at very short intervals so as to permit a telephone call to be established in “real-time” is eliminated. Therefore, the paging interval can be increased substantially, thereby substantially prolonging battery charge lifetime of the telephone. In accordance with another aspect of the invention, when a cellular telephone sends a pre-call SMS, it temporarily decreases its paging interval to a more conventional interval such as 0.5 seconds for a predetermined period of time (e.g., 1-5 minutes) after placing a call so that, if the called party returns the call, the calling party will receive the return call in real-time and be able to answer the incoming call and establish a voice call. | 05-26-2011 |
20120243424 | CARRIER-PHASE DIFFERENCE DETECTION AND TRACKING IN MULTIPOINT BROADCAST CHANNELS - Methods and apparatus are described that provide carrier-phase difference (CPD) acquisition via signaling protocols between communicating devices. The random CPD between two disjoint devices can be measured by the signaling protocols described herein. With the availability of the CPD, a device is also able to acquire its outgoing channel (transmit channel) information, thus avoiding the channel information feedback that is being considered and/or practiced in some wireless communications systems. Also described are methods and apparatus that use the CPD to synchronize the clocks of two or more devices and that track the time-variations of the CPD for reliable CPD measurement and tracking loop operations. Applications of the described methods and apparatus include wireless multipoint broadcast systems, also known as coordinated multipoint transmission, or CoMP, in LTE (long-term evolution)-advanced systems, point-to-point wireless MIMO systems, and general wireless device networks. | 09-27-2012 |
20120278690 | Method and Apparatus for Performing a CRC Check - A description is given of an apparatus that includes a division unit configured to receive a data stream and to divide the received data stream into a plurality of data segments. The apparatus further includes a plurality of first CRC check units, wherein each of the first CRC check units is configured to perform a first CRC check of a respective one of the plurality of data segments, the plurality of first CRC checks being performed concurrently, and wherein each of the first CRC check units is configured to perform a second CRC check based on an output of the respective first CRC check unit. | 11-01-2012 |
20120320765 | Carrier-Phase Difference Detection With Mismatched Transmitter And Receiver Delays - Methods and apparatus are described that provide efficient detection of the carrier-phase difference (CPD) between communicating devices over the entire signal bandwidth. The CPD detection utilizes the linear structure of the CPD, which eliminates most of the feedback overhead. Both feedback mechanisms, compact digitized feedback, and feedback via fast signaling protocols, are described. The CPD can be decomposed into a fixed/slow-changing portion and a fast-varying portion, with the former being pre-calibrated and communicated prior to communications sessions, thus further reducing the feedback overhead and improving the CPD detection accuracy. The nonlinearity in the TX/RX chains can also be pre-calibrated, allowing CPDs with more general structures to be detected by methods that detect CPDs with linear structures. Applications of the described methods and apparatus include wireless multipoint broadcast systems, also known as coordinated multipoint transmission, or CoMP, in LTE-A (long-term evolution, advanced) systems, and frequency and phase synchronization of a cluster of base stations. | 12-20-2012 |
20130029586 | PHASE SYNCHRONIZATION OF BASE STATIONS VIA MOBILE FEEDBACK IN MULTIPOINT BROADCASTING - Multipoint broadcasting requires the base stations to be phase-synchronized. Methods and apparatus are described that provide phase synchronization of base stations with the downlink-channel phase feedback by mobile users. Also described are methods and apparatus that make phase synchronization of base stations independent of multipoint-broadcast sessions, thus reducing the synchronization overhead and improving network capacity. The methods and apparatus utilize model-based downlink-channel phase feedback that reduces most of the feedback overhead. Applications of the described methods and apparatus include wireless multipoint broadcast systems, also known as coordinated multipoint transmission, or CoMP, in LTE-A (long-term evolution, advanced) systems, and frequency and phase synchronization of a cluster of base stations, or more generally, of a cluster of wireless devices. | 01-31-2013 |
20130083778 | Wideband Analog Channel Information Feedback - Multipoint broadcasting requires that the downlink-channel information be available at collaborating base stations. Methods and apparatus for wideband analog channel feedback are described that provide downlink-channel information feedback from mobile users to base stations via uplink channels, and that use very few or no resources of the RAT of the wireless cellular network. Also described are methods and apparatus that perform channel-feedback signal cancellation at base stations to reduce its interference on the uplink-traffic signal. Wideband analog channel feedback is adaptable to the feedback bandwidth in uplink, and it offers frequency diversity to combat the deep fading in feedback channels. Wideband analog channel feedback is also applicable to uplink channel-information feedback. Applications of the described methods and apparatus include multipoint broadcasting in a wireless cellular network, and more generally, channel feedback between two communicating devices in a communications network. | 04-04-2013 |
20130121379 | Heterogeneous Pilots - Large-dimension MIMO and multipoint broadcasting in new generation of wireless networks create high demand for various types of pilots in transmission signals for channel estimation, data demodulation, synchronization, etc. More pilots, as in existing networks, use more resources and thus diminish the network capacity. Methods and apparatus of heterogeneous pilots are disclosed. A heterogeneous pilot has its own signal characteristics that are different from the primary information-bearing signals in the network. Heterogeneous pilots can be spread-spectrum signals in an OFDM-based wireless network. Heterogeneous pilots use no network resources, and can be as many as desired, and can be designed to have versatile utilities. Also described are methods and apparatus of heterogeneous pilot cancellation that minimizes the interference of heterogeneous pilots on the primary information-bearing signals. Applications of the described methods and apparatus include OFDM-based wireless cellular networks, such as LTE-advanced and Wireless LAN. | 05-16-2013 |
20130242841 | Channel Feedback In OFDM Systems - Methods and apparatus of channel feedback are disclosed. In OFDM systems, the channel is acquired in the frequency domain. A generic multipath model for wireless channels, however, reveals that the time-domain parameters of the channel require much smaller data than the frequency-domain representation of the channel. Means to extracting the time-domain parameters from the frequency-domain channel samples are described for both the continuous time domain and the discrete time domain. Refinements of the time-domain parameters via minimizing a frequency-domain matching error are also described, which further improve the quality of the channel feedback and reduce the feedback overhead. Channel feedback with the time-domain parameters requires only a small fraction of the feedback overhead that is needed by existing channel feedback schemes, and maintains consistently superior performances over wireless channels of various delay spreads, short or long. | 09-19-2013 |
20140098704 | Channel Estimation By Time-Domain Parameter Extraction - Methods and apparatus of channel estimation using time-domain parameter extraction are disclosed. The wireless channel can be modeled by a multipath model with a limited number of parameters in the continuous time domain. In the discrete time domain, the multipath model leads to channel impulse responses that have a limited number of channel taps with non-negligible energy. Extracting the time-domain parameters and then reconstructing the channel yields channel estimates that have better accuracy. Time-domain parameter extraction also has lower computational complexity than existing methods. | 04-10-2014 |
20140233684 | Sparse Channel Detection, Estimation, And Feedback - Most wireless channels are sparse, so sparse channel-based methods can be used for channel estimation and feedback with much better estimation accuracy and much lower feedback overhead. However, certain wireless channels can be non-sparse, for which sparse channel-based methods may cause degraded estimation quality and increased feedback overhead. Means of detecting the channel sparseness are described that provide simple and effective channel sparseness indicators and safeguard against the mismatch between non-sparse channels and sparse channel-based methods. Various fallback options can be used under non-sparse channels such that estimation degradation and feedback overhead are both minimized. Fake multipath removal in continuous time-domain parameter extraction, a sparse channel-based method, is also described that further improves estimation quality and reduces feedback overhead. | 08-21-2014 |
20140293803 | Coordinated Multi-Point Transmission and Multi-User MIMO - MU-MIMO and CoMP have potentials to increase the cell capacity by many folds. Interferences and channel feedback overhead, however, severely limits such potentials. Method of reference signal-based grid of beams (RS-GOB) is described. RS-GOB distributes the effective antennas of a base station into multiple beams, thereby significantly reducing the feedback overhead of CoMP and making effective use of CoMP to turn the interferences into cooperating useful signals. RS-GOB also reduces the need for small HetNet cells, which mitigates the interferences of small HetNet cells on macro cells. | 10-02-2014 |
Patent application number | Description | Published |
20090130284 | PROCESS FOR PREPARING RED COCOA INGREDIENTS, RED CHOCOLATE, AND FOOD PRODUCTS - The invention provides acidified red cocoa products and ingredients, such as acidified red cocoa bean nibs, red cocoa liquor, and red cocoa powder. The acidified cocoa products and ingredients are generally made from under-fermented or unfermented cocoa beans that are treated with an acid composition. The methods include those of making food products and ingredients where the levels cocoa antioxidants are maintained by the use of an acid treatment and the avoidance of dutching, and the food products and ingredient have a distinctive red color. Cocoa nibs, chocolate or cocoa liquor and cocoa powders having a red hue or color and having high levels of cocoa antioxidants are disclosed, as well as food products made from them. | 05-21-2009 |
20120237662 | METHOD OF MAKING A REDUCED FAT CHOCOLATE CONFECTIONERY PRODUCT - A method for creating a reduced fat confectionery product is disclosed. The method includes providing a mixture of a chocolate compatible fat and a sweetener, thereafter refining the mixture to form a powder having a predetermined average particle size, thereafter agitating the refined powder mixture at a temperature above the melting temperature of the chocolate compatible fat to form a dough and thereafter solidifying the dough to form a confectionery product having a total formulated fat content of less than 29% by weight. | 09-20-2012 |
20120237665 | METHOD OF MAKING A HEAT STABLE CHOCOLATE CONFECTIONERY PRODUCT - A method of producing a heat resistant chocolate confectionery product is disclosed. The method provides for such products to be made without the addition of water and which can be made with traditional chocolate making ingredients to yield a dough. The dough retains its shape above the melting point of fats in the product, while the product still retains a flavor and mouthfeel comparable with chocolate made by traditional methods. | 09-20-2012 |
20120276249 | COCOA NUGGETS AND METHOD OF MAKING SAME - Cocoa nuggets and methods for their manufacture are disclosed. The nuggets are formed by providing a dough including, on a dry basis, at least 30% by weight cocoa powder, the dough having a moisture content of at least 10% to about 52% by weight. The dough is processed into nuggets having a moisture content of not greater than about 15% by weight. The nuggets can be crunchy or chewy and can be used as an ingredient such as an inclusion or a topping for food products in order to increase antioxidant levels and the method of creating the nuggets results in minimal loss of antioxidant capacity as a result of processing. | 11-01-2012 |
20140186511 | COCOA NUGGETS AND METHOD OF MAKING SAME - Cocoa nuggets and methods for their manufacture are disclosed. The nuggets are formed by providing a dough including, on a dry basis, at least 30% by weight cocoa powder, the dough having a moisture content of at least 10% to about 52% by weight. The dough is processed into nuggets having a moisture content of not greater than about 15% by weight. The nuggets can be crunchy or chewy and can be used as an ingredient such as an inclusion or a topping for food products in order to increase antioxidant levels and the method of creating the nuggets results in minimal loss of antioxidant capacity as a result of processing. | 07-03-2014 |
20150024093 | COCOA AND SUGAR AGGLOMERATE FOR FLAVORED BEVERAGES AND METHOD OF FORMING SAME - A method of forming cocoa and sugar base agglomerates is disclosed in which cocoa powder and sugar is mixed with an aqueous ethanol solution to form a dough and the dough is dried to form agglomerates of a porous dried dough having less than 0.5% by weight residual ethanol. The dried dough may be broken into pieces or formed into pieces by cutting prior to drying. The resulting pieces of the agglomerate disintegrate instantly in a cold aqueous liquid, such as water or milk, to form a flavored beverage. | 01-22-2015 |
Patent application number | Description | Published |
20100120788 | IDENTIFICATION OF POLYNUCLEOTIDES FOR PREDICTING ACTIVITY OF COMPOUNDS THAT INTERACT WITH AND/OR MODULATE PROTEIN TYROSINE KINASES AND/OR PROTEIN TYROSINE KINASE PATHWAYS IN PROSTATE CELLS - The present invention describes polynucleotides that have been discovered to correlate to the relative intrinsic sensitivity or resistance of cells, e.g., prostate cell lines, to treatment with compounds that interact with and modulate, e.g., inhibit, protein tyrosine kinases, such as, for example, members of the Src family of tyrosine kinases, e.g., Src, Fgr, Fyn, Yes, Blk, Hck, Lck and Lyn, as well as other protein tyrosine kinases, including, Bcr-abl, Jak, PDGFR, c-kit and Eph receptors. These polynucleotides have been shown to have utility in predicting the resistance and sensitivity of prostate cell lines to the compounds. The expression level or phosphorylation status of some polynucleotides is regulated by treatment with a particular protein tyrosine kinase inhibitor compound, thus indicating that these polynucleotides are involved in the protein tyrosine kinase signal transduction pathway, e.g., Src tyrosine kinase. Such polynucleotides, whose expression levels correlate highly with drug sensitivity or resistance and which are modulated by treatment with the compounds, comprise polynucleotide predictor or marker sets useful in methods of predicting drug response, and as prognostic or diagnostic indicators in disease management, particularly in those disease areas, e.g., prostate cancer, in which signaling through the protein tyrosine kinase pathway, such as the Src tyrosine kinase pathway, is involved with the disease process. | 05-13-2010 |
Patent application number | Description | Published |
20100021388 | BENZOTHIAZOLE DERIVATIVE COMPOUNDS, COMPOSITIONS AND USES - This invention provides benzothiazole derivative compounds, compositions comprising such compounds, methods of preparing such compounds, and methods of using such compounds for detecting amyloid deposit(s) and for diagnosing a disease, disorder or condition characterized by amyloid deposit(s). | 01-28-2010 |
20110257407 | THIOFLAVIN DERIVATIVES FOR USE IN ANTEMORTEM DIAGNOSIS OF ALZHEIMER'S DISEASE AND IN VIVO IMAGING AND PREVENTION OF AMYLOID DEPOSITION - This invention relates to novel thioflavin derivatives, methods of using the derivatives in, for example, in vivo imaging of patients having neuritic plaques, pharmaceutical compositions comprising the thioflavin derivatives and method of synthesizing the compounds. The compounds find particular use in the diagnosis and treatment of patients having diseases where accumulation of neuritic plaques are prevalent. The disease states or maladies include but are not limited to Alzheimer's disease, familial Alzheimer's disease, Down's Syndrome and homozygotes for the apolipoprotein E4 allele. | 10-20-2011 |
20120095235 | THIOFLAVIN DERIVATES FOR USE IN THE ANTEMORTEM DIAGNOSIS OF ALZHEIMER'S DISEASE AND IN VIVO IMAGING AND PREVENTION OF AMYLOID DEPOSITION - This invention relates to novel thioflavin derivatives, methods of using the derivatives in, for example, in vivo imaging of patients having neuritic plaques, pharmaceutical compositions comprising the thioflavin derivatives and method of synthesizing the compounds. The compounds find particular use in the diagnosis and treatment of patients having diseases where accumulation of neuritic plaques are prevalent. The disease states or maladies include but are not limited to Alzheimer's Disease, familial Alzheimer's Disease, Down's Syndrome and homozygotes for the apolipoprotein E4 allele. | 04-19-2012 |
20130004422 | BENZOTHIAZOLE DERIVATIVE COMPOUNDS, COMPOSITIONS AND USES - This invention provides benzothiazole derivative compounds, compositions comprising such compounds, methods of preparing such compounds, and methods of using such compounds for detecting amyloid deposit(s) and for diagnosing a disease, disorder or condition characterized by amyloid deposit(s). | 01-03-2013 |
20130236394 | THIOFLAVIN DERIVATIVES FOR USE IN ANTEMORTEM DIAGNOSIS OF ALZHEIMER`S DISEASE AND IN VIVO IMAGING AND PREVENTION OF AMYLOID DEPOSITION - This invention relates to novel thioflavin derivatives, methods of using the derivatives in, for example, in vivo imaging of patients having neuritic plaques, pharmaceutical compositions comprising the thioflavin derivatives and method of synthesizing the compounds. The compounds find particular use in the diagnosis and treatment of patients having diseases where accumulation of neuritic plaques are prevalent. The disease states or maladies include but are not limited to Alzheimer's disease, familial Alzheimer's disease, Down's Syndrome and homozygotes for the apolipoprotein E4 allele. | 09-12-2013 |
20140220590 | METHODS OF USING BENZOTHIAZOLE DERIVATIVE COMPOUNDS AND COMPOSITIONS - This invention provides benzothiazole derivative compounds, compositions comprising such compounds, methods of preparing such compounds, and methods of using such compounds for detecting amyloid deposit(s) and for diagnosing a disease, disorder or condition characterized by amyloid deposit(s). | 08-07-2014 |
Patent application number | Description | Published |
20090019512 | System Method and Computer Readable Medium for Multicasting Control Messages to a Set Top Box - A system, method and computer readable medium are disclosed that allow a set top box to receive control messages transmitted using multicasting. The set top box is programmed with either an address or a URL that it uses to obtain the control messages directly, or obtain other messages that carry the multicast address. In other implementations, a specialized offer message is transmitted to the set top box in response to a discover message. Embedded within the specialized offer message is the multicast address being used to multicast the control messages. | 01-15-2009 |
20090144797 | Method and Apparatus for Delivering SDV Programming With Multiple Advertisements - A set top terminal is provided that includes a receiver/tuner for receiving (i) switched digital video (SDV) programs over a broadband access network, at least one of the SDV programs including a primary advertisement and (ii) a plurality of alternative advertisements that are each substitutable for the primary advertisement. The set top terminal also includes a processor operationally associated with the receiver/tuner. The processor is configured to selectively cause a first of the alternative advertisements to be rendered instead of the primary advertisement when the first alternative advertisement better matches a prescribed condition than the primary advertisement. | 06-04-2009 |
20100123822 | Method for Converting Between Display Information Scales | 05-20-2010 |
20100272419 | DIGITAL VIDEO RECORDER RECORDING AND RENDERING PROGRAMS FORMED FROM SPLICED SEGMENTS - A method and apparatus is provided for recording a program. The method includes storing, in response to a use request, at least one content file that includes first and second program segments that are spliced to form a single program. At least one index file is created and stored. The file index includes program specific information associated with the first and second program segments. The index file also includes an identification of a splice point denoting a transition between the first and second program segments. In addition, a splice index is created and stored. The splice index includes timing information specifying a time at which the splice point occurs. | 10-28-2010 |
20110078002 | ALTERNATIVE ADVERTISEMENT PLACEMENT IN RECORDED CONTENT STREAMS - A set top box includes a tuner for receiving a switched digital video (SDV) stream from an SDV source, in which the SDV stream contains content and a default advertisement. The set top box also includes a memory for storing the SDV stream and a controller for generating and outputting an ad catalog to at least one of an ad server and an SDV manager, in which the ad catalog contains information useable by the ad server in identifying one or more alternative advertisements to be played by the set top box during play of the SDV stream in place of the default advertisement, and in which the controller is configured to receive the one or more alternative advertisements and to replace the default advertisement in the SDV stream. | 03-31-2011 |
20110096720 | Method and System for Managing Information Within a Network - A method and system for managing information using a gateway ( | 04-28-2011 |
20110154389 | SYSTEM AND METHOD FOR ADDING CONTENT DURING DATA STREAM ACQUISITION - A device is provided for use with extended content data on a first data stream and second content data on a second data stream. The device includes a processing portion, an acquisition portion and a buffer. The acquisition portion is in communication with the processing portion. The acquisition portion can acquire the first data stream, can transition to the second data stream to receive the second content data and can provide the second content data to the processing portion. The buffer can receive the extended content data. The processing portion can instruct the acquisition portion to transition from the first data stream to the second data stream to receive the second content data. The buffer can further provide the extended content data to the processing portion based on the acquisition portion transitioning from the first data stream to the second data stream. The processing portion can further process the extended content data portion as received from the buffer. | 06-23-2011 |
20110321077 | VIEWING IMPRESSION REPORT COLLECTION, STORAGE, AND REPORTBACK OF INSERTED CONTENT WITH DVR PLAYBACK - A method and system that computes viewing statistics for a digital video content stream received at a set-top box. The digital video content stream includes a first segment of video content, a second segment of video content, a third segment of video content, a first timing mark that indicates a transition from the first segment to the second segment, and a second timing mark that indicates a transition from the second segment to the third segment. The method initiates a transmission of the digital video content stream at the set-top box, monitors the transmission of the digital video content stream relative to the first timing mark and the second timing mark, and computes view data for the second segment based on the monitoring of the transmission. The method stores the view data at the set-top box. | 12-29-2011 |
20120144420 | TARGETED ADVERTISEMENT DISTRIBUTION IN AN SDV ENVIRONMENT - A system and method for distributing targeted advertisements in a switched digital video system. The method monitors a content stream associated with a channel selected by a subscriber, where the content stream includes an advertisement segment having a start time and an end time, and an advertisement replacement opportunity inserted in the content stream. The method detects the advertisement replacement opportunity at a detection time that is prior to the start time of the advertisement segment, and sends a request to select an advertisement replacement for the advertisement segment, thereby broadcasting a service associated with the advertisement replacement prior to the start time for the advertisement segment. The method receives tune data to identify an advertisement replacement stream associated with the advertisement replacement, and tunes to the advertisement replacement at the start time for the advertisement segment. | 06-07-2012 |
20120151532 | SDV QUICK TUNE ALGORITHM - A switched digital video (SDV) system and method that provides a seamless transition when tuning a set-top box from a first SDV service to a second SDV service. The method detects a set up service trigger in a content stream before a tune request time to transition the content stream from the first SDV service to the second SDV service, and sends a request to set up the second SDV service at a time before the tune request time, where a time difference between the time and the tune request time is greater than a service set up time for the second SDV service. The method detects a tune request in the content stream for the second SDV service, sends a service select request to tune to the second SDV service, and receives the second SDV service at the tune request time. | 06-14-2012 |
20130002812 | ENCODING AND/OR DECODING 3D INFORMATION - There is an encoding of three dimensional (3D) information. The encoding may include receiving a signal including frames in a 3D video sequence, receiving caption information to appear in a caption window associated with the frames, and/or receiving disparity information associated with the frames. The encoding may also include determining frame disparity maps based on the disparity information associated with the frames. The frame disparity maps may be determined by dividing a part of a frame into a plurality of grid cells. The grid cells may define a disparity measure associated with locations in a grid. The grid cells may form a caption window disparity map dividable into equivalent size portions including an equivalent amount of grid cells. The encoding may also include encoding the frames, the caption information and the frame disparity maps. There is also a decoding of the 3D information. | 01-03-2013 |
20130081078 | Method for Tag Insertion and Notification for DVR Addressable Advertisement - A method and computing device that provides viewer impression data for a recorded digital video stream. The method receives a digital video stream as a series of segments, and stores it as a recorded digital video stream having a transition between two consecutive segments at a transition position. The method stores a notification tag that is associated with the transition, and that includes a tag position in the recorded digital video stream, a notification mode, and tag data. During playback of the recorded digital video stream, the method generates a play mode status event, and generates a transition notification when the playback encounters the notification tag and, based on the notification mode, the transition associated with the notification tag. The method collects viewer impression data for one of the two consecutive segments from the play mode status event and the transition notification. | 03-28-2013 |
20140043538 | Two-Way HDMI Communication - A device is provided for use with an audiovisual device and an HDMI cable having a first end and a second end. The first end can connect to the audiovisual device, whereas the second end can connect to the device. The audiovisual device can provide power to the power line of the HDMI cable when providing the digital television audiovisual signals. The device includes an output portion, and input portion and a control portion. The output portion can provide output signals as the digital television audiovisual signals to the second end. The input portion can receive input signals as the digital television audiovisual signals from the second end. The control portion can instruct the output portion to output the digital television audiovisual signals to the second end or can instruct input portion to receive the digital television audiovisual signals from the second end based on the power. | 02-13-2014 |
20140043539 | Power for an HDMI Source Device - A device is provided for use with an audiovisual device and a cable having a first end and a second end. The audiovisual device can receive digital television audiovisual signals. The cable includes a data channel, a control channel and a power line and can transmit the digital television audiovisual signals. The first end can connect to the audiovisual device, whereas the second end can connect to the device. The device includes a connector, a detecting portion and a power source. The connector can connect to the second end. The detecting portion can generate a connection signal based on a connection of the connector to the second end. The power source can provide power based on the connection signal. | 02-13-2014 |
20140279047 | ENHANCING TARGETED ADVERTISING IN A HOME NETWORK GATEWAY DEVICE - Advanced set top devices are beginning to merge with home network gateway devices and will soon become the major single entry point into the home. A growing trend and implementation of home gateways is to provide a centralized data entrance point to end user home. Behavioral information may be compiled from each individual device in the home network, and the home network gateway device determines advertisements to insert specifically to each device based on the entirety of the behavioral information compiled from within the home network. The advertisements provided to individual users within the home network may be determined by the home network gateway device, transparent to entities outside the home network. For example, a headend that delivers content to a home network may not know how many devices are connected to a home network gateway device, the type of devices connected, or which devices are receiving content. | 09-18-2014 |
20140282775 | SYSTEM AND METHOD FOR DELIVERING 3DTV CONTENT TO VARIETY OF RECEIVERS - An internet protocol multicast provider is disclosed, which includes a bootstrap code component, a transcoder generator component, a content module and a packetizing module. The bootstrap code component can generate a bootstrap code. The transcoder generator component can generate a transcoder module. The content module can generate content in a first format. The packetizing module can generate internet protocol multicast packets, based on the bootstrap code, the transcoder module and the content. The bootstrap code can determine a second format for which an internet protocol multicast receiver can decode and render the content. The transcoder module can instruct the internet protocol multicast receiver to play the content when the first format is the second format. The transcoder module can instruct the internet protocol multicast receiver to transcode the content from the first format to the second format when the first format is not the second format. | 09-18-2014 |
Patent application number | Description | Published |
20100177277 | ELECTRO-ACTIVE SPECTACLES AND ASSOCIATED ELECTRONICS - Aspects of the present invention provide electronics for controlling and synchronizing operation of electro-active lenses regardless of frame type, size or style. The controlling electronics can be contained within one or more electronic modules positioned within the frame temples and can be removable and reprogrammable and can include inductive charge regions. Conductive links between electronic modules and/or between left and right sides of the electro-active spectacles can include left and right upper and lower rim portions of the frame, the bridge, conductive layers of the electro-active lenses, the upper and lower grooves of the electro-active lenses, and/or wires embedded within any portion of the frame. Aspects of the present invention also provide chargers for recharging electro-active spectacles of any size, shape or style using adjustable inductive charging cradles to inductively charge electro-active spectacles of the present invention. | 07-15-2010 |
20120127420 | ELECTRONIC SPECTACLE FRAMES - Embodiments may provide a first device that includes a frame having a first temple and a second temple. The frame may also comprise a housing module coupled (e.g. attached) to a structural member. The first device may further include a first lens and a second lens coupled to the frame and an electronics module that may be located within the housing module. The electronics module may include at least any two of: a power source; a controller; and/or a sensing mechanism. | 05-24-2012 |
20120127423 | ELECTRONIC SPECTACLE FRAMES - Embodiments may provide a first device that comprises eyeglasses, where the eyeglasses may further include a lens housing, a first temple and a second temple coupled to the lens housing, and a first and a second lens supported by the lens housing. The first device may further include a façade that covers the lens housing. The first device may further comprise an electronic component and at least one conductive path may be provided from the electronic component to the first lens having a portion that runs through the lens housing. | 05-24-2012 |
20130010256 | ELECTRO-ACTIVE SPECTACLE FRAMES - A first device is provided. The first device includes a lens comprising at least a first electrical contact and a lens housing holding the lens. The lens housing includes at least a second electrical contact. The first device further comprises a compliant conductive element disposed between the first and the second electrical contact. The compliant conductive element electrically connects the first and second electrical contacts. | 01-10-2013 |
20130144185 | Devices and Methods for Noninvasive Measurement of Intracranial Pressure - Provided are systems and methods for noninvasively assessing intracranial pressure by controllably applanating at least a portion of a subject's ocular globe so as to collapse an intraocular blood vessel and correlating the collapse pressure to intracranial pressure. Also provided are ophthalmic components useful in ophthalmic imaging applications, as well as methods of assessing intracranial pressure that are based, at least in part, on the degree of papilledema, if any, present in the subject. | 06-06-2013 |
20130215374 | EYEWEAR DOCKING STATION AND ELECTRONIC MODULE - An eyewear system including an eyewear frame and an application module. The eyewear frame including a docking station, and an electronic connector including a first set of preconfigured application connection points. The application module adapted to be mounted to the docking station, and including an electronic device configured to perform a function, and a second set of preconfigured application connection points corresponding to at least some of the first set of preconfigured application connection points. The second set of preconfigured application connection points including at least two different sub-function connections used to support the function of the electronic device. | 08-22-2013 |
20130278881 | Electro-Active Spectacles and Associated Electronics - Aspects of the present invention provide electronics for controlling and synchronizing operation of electro-active lenses regardless of frame type, size or style. The controlling electronics can be contained within one or more electronic modules positioned within the frame temples and can be removable and reprogrammable and can include inductive charge regions. Conductive links between electronic modules and/or between left and right Sides of the electro active spectacles can include left and right upper and lower rim portions of the frame, the bridge, conductive layers of the electro-active lenses, the upper and lower grooves of the electro-active lenses, and/or wires embedded within any portion of the frame. Aspects of the present invention also provide chargers for recharging electro-active spectacles of any size, shape or style using adjustable inductive charging cradles to inductively charge electro-active spectacles of the present invention. | 10-24-2013 |
20140028966 | Electronic Eyeglasses and Methods of Manufacturing - Disclosed herein are devices and methods for the design and manufacturing of electronic eyeglasses and associated components thereof. Electronic eyeglasses consist of electro-active lenses, receiving electrical signals that turn them on and off from an electronic control module. The electronic control module is embedded within a temple of the eyeglass frame, and is powered by a removable power source pack residing at a temple tip through a flexible cable. Various methods describe the interconnection schemes between the components of the electronic eyeglasses. | 01-30-2014 |
20140293215 | Spectacles - A device includes a lens, a lens housing configured to support the lens, an end piece, and a plurality of vertebrae. One of the plurality of vertebrae is coupled to the end piece. The device also includes a temple coupled to another one of the plurality of vertebrae, an electronics module coupled to the temple, and a conductive path provided from the electronics module to the lens housing. The plurality of vertebrae are configured to allow the temple to move relative to the lens housing, and the vertebrae cover a portion of the conductive path. | 10-02-2014 |
Patent application number | Description | Published |
20080267326 | Multi-channel receiver with improved AGC - An improved multi-channel receiver for satellite broadcast applications or the like. In an exemplary embodiment, an AGC loop, under the control of an AGC processor, controls the gain of an analog sub-receiver adapted to simultaneously receive multiple signals to achieve a desired AGC setpoint signal intensity from the sub-receiver. Multiple digital demodulators, coupled to the sub-receiver by an analog-to-digital converter (ADC), demodulate the multiple received signals. The AGC controller, based upon which of the received signals are being demodulated, selects the desired AGC setpoint from a table of setpoints. The AGC controller may also provide selective power control to circuitry in the receiver and select the resolution of the ADC. The controller updates the AGC loop with step values selected from a group of values by an AGC control algorithm. Different groups of step values may be used by the controller depending on whether the signals are fading or not. | 10-30-2008 |
20080268798 | Multi-channel receiver with improved AGC - An improved multi-channel receiver for satellite broadcast applications or the like. In an exemplary embodiment, an AGC loop, under the control of an AGC processor, controls the gain of an analog sub-receiver adapted to simultaneously receive multiple signals to achieve a desired AGC setpoint signal intensity from the sub-receiver. Multiple digital demodulators, coupled to the sub-receiver by an analog-to-digital converter (ADC), demodulate the multiple received signals. The AGC controller, based upon which of the received signals are being demodulated, selects the desired AGC setpoint from a table of setpoints. The AGC controller may also provide selective power control to circuitry in the receiver and select the resolution of the ADC. The controller updates the AGC loop with step values selected from a group of values by an AGC control algorithm. Different groups of step values may be used by the controller depending on whether the signals are fading or not. | 10-30-2008 |
20090110047 | DEMODULATOR WITH CONFIGURABLE ADAPTIVE EQUALIZER - An improved multi-channel receiver for satellite broadcast applications or the like. In an exemplary embodiment, the receiver has an adaptive equalizer configurable to operate with QPSK or 8PSK modulated signals. In the equalizer, a slicer table memory responsive to an 8-level quantizer (slicer) and a select signal is configured to map the output of the quantizer into QPSK or 8PSK symbol coordinates depending on whether the QPSK or the 8PSK signal is being received. The slicer table memory may be loaded with the symbol coordinates calculated from data in the 8PSK signal. A pattern matcher determines if the 8PSK or the QPSK signal is being received and asserts the select signal to configure the slicer table memory accordingly. | 04-30-2009 |
20110188489 | MULTI-CHANNEL RECEIVER WITH IMPROVED AGC - An improved multi-channel receiver for satellite broadcast applications or the like. In an exemplary embodiment, a primary AGC loop controls an analog sub-receiver adapted to simultaneously receive multiple signals. Multiple digital demodulators, coupled to the sub-receiver, demodulate the multiple received signals. Multiple secondary AGC loops, one for each received signal, compensate for variations in demodulated signal strengths caused by the primary AGC loop. A feed-forward AGC compensation technique generates scalar control values for scaling the demodulated signals before the demodulated signals are processed by the secondary AGC loops. This at least partially compensates for gain variations caused by the primary AGC, reducing received signal drop-outs before the secondary AGC loops can compensate for the gain variations. Because of systemic delays in the sub-receiver and the demodulators, the scalar control values are independently timed to be coincident with the variations in the demodulated signal strengths caused by the primary AGC loop. | 08-04-2011 |
Patent application number | Description | Published |
20080242846 | O-LINKED GLYCOSYLATION OF PEPTIDES - The present invention provides polypeptides that include an O-linked glycosylation site that is not present in the wild-type peptide. The polypeptides of the invention include glycoconjugates in which a species such as a water-soluble polymer, a therapeutic agent of a biomolecule is covalently linked through an intact O-linked glycosyl residue to the polypeptide. Also provided are methods of making the peptides of the invention and methods, pharmaceutical compositions containing the peptides and methods of treating, ameliorating or preventing diseased in mammals by administering an amount of a peptide of the invention sufficient to achieve the desired response. | 10-02-2008 |
20090169509 | O-linked glycosylation of peptides - The present invention provides polypeptides that include an O-linked glycosylation site that is not present in the wild-type peptide. The polypeptides of the invention include glycoconjugates in which a species such as a water-soluble polymer, a therapeutic agent of a biomolecule is covalently linked through an intact O-linked glycosyl residue to the polypeptide. Also provided are methods of making the peptides of the invention and methods, pharmaceutical compositions containing the peptides and methods of treating, ameliorating or preventing diseased in mammals by administering an amount of a peptide of the invention sufficient to achieve the desired response. | 07-02-2009 |
20100324274 | NOVEL SYNTHETIC GANGLIOSIDE DERIVATIVES AND COMPOSITIONS THEREOF - Novel synthetic gangliosides and pharmaceutical compositions containing such synthetic gangliosides are described. Methods of making the novel synthetic ganglioside compounds and compositions as well as their use in the field of neuroprotection and cancer treatment is also described. | 12-23-2010 |
20120016105 | PURIFICATION OF PEPTIDE CONJUGATES BY HYDROPHOBIC INTERACTION CHROMATOGRAPHY - The present invention provides polypeptides that include an O-linked glycosylation site that is not present in the wild-type peptide. The polypeptides of the invention include glycoconjugates in which a species such as a water-soluble polymer, a therapeutic agent of a biomolecule is covalently linked through an intact O-linked glycosyl residue to the polypeptide. Also provided are methods of making a glycoconjugate, methods of isolating a glycoconjugate from a reaction mixture, pharmaceutical compositions containing a glycoconjugate, and methods of treating, ameliorating or preventing diseased in mammals by administering an amount of a glycoconjugate sufficient to achieve the desired response. | 01-19-2012 |