Patent application number | Description | Published |
20120179486 | INDIVIDUALIZED ALLOCATION OF HEALTH RESOURCES - The present invention discloses methods, computer program and system to overcome the limitation of the current clinical practice. This is achieved by using information technology and the vast amount of epidemiological data available to create algorithms that calculate the risk or severity profile of an individual with any given disease. The individual profile presents the current condition and/or position of the individual in comparison with the mean base curve of the total population and in accordance with upper and lower risk limits. The individual profile is then fitted with its optimal use of healthcare resources, such as medication, surgery, laser treatment, surveillance and follow-up, to optimize and individualize the health outcome of this individual, and at the same time optimize and individualize the allocation of healthcare resources within the system. | 07-12-2012 |
20130296182 | VARIABILITY SINGLE NUCLEOTIDE POLYMORPHISMS LINKING STOCHASTIC EPIGENETIC VARIATION AND COMMON DISEASE - Provided are methods and models for an alternative source of disease risk, which identifies not genetic variants for a phenotype per se, but variants for variability itself. Also provided are methods and models for a genome-scale, gene-specific analysis of DNA methylation in the same individuals over time, in order to identify a personalized epigenomic signature that may correlate with common genetic disease. Also provided are methods and models for simulating stochastic epigenetic variation as a driving force of development, evolutionary adaptation, and disease. | 11-07-2013 |
Patent application number | Description | Published |
20090304817 | Glycosylation Variants of Ricin-Like Proteins - The present invention provides glycosylation variants of recombinant proteins and nucleic acids that encode such recombinant proteins, which are useful as therapeutics against cancer, and viral, parasitic and fungal infections. The proteins and nucleic acids have A and B chains of ricin-like toxin linked by a linker sequence that is specifically cleaved and activated by proteases specific to disease-associated pathogens or cells. The invention also relates to methods of inhibiting or destroying cells affected by a disease, methods of treating a mammal with a disease, and pharmaceutical compositions using the recombinant proteins and nucleic acids of the invention. | 12-10-2009 |
20110144004 | RICIN-LIKE TOXIN VARIANTS FOR TREATMENT OF CANCER, VIRAL OR PARASITIC INFECTIONS - The present invention provides a protein having an A chain of a ricin-like toxin, a B chain of a ricin-like toxin and a heterologous linker amino acid sequence, linking the A and B chains. The linker sequence contains a cleavage recognition site for a disease specific protease such as a cancer, fungal, viral or parasitic protease. The invention also relates to a nucleic acid molecule encoding the protein and to expression vectors incorporating the nucleic acid molecule. Also provided is a method of inhibiting or destroying mammalian cancer cells, cells infected with a virus, a fungus, or parasite, or parasites utilizing the nucleic acid molecules and proteins of the invention and pharmaceutical compositions for treating human cancer, viral infection, fungal infection, or parasitic infection. | 06-16-2011 |
Patent application number | Description | Published |
20090000817 | Current Conductor for an Electrical Device, Especially Bus Bar Conductor for an Electrical Medium Voltage Installation - A current conductor for an electrical device including an electrically conducting central section having a first side and a second side. The central section is configured to receive at least one inserted electrical component. Two electrical conducting shield sections are each disposed on one of the first side and the side and configured to shield against an electric field. The shield sections cover the central section and the at least one inserted electrical component. | 01-01-2009 |
20090008229 | CONTACT SYSTEM FOR A SHORT-CIRCUITING DEVICE IN A MEDIUM-VOLTAGE OR HIGH-VOLTAGE SWITCHBOARD PLANT - A contact system for a short-circuiting device for a switchboard, the contact system including at least one fixed contact piece connected to a main voltage source. The contact system also includes at least one moving contact piece and an insulating screen penetrable using the at least one moving contact piece so as to make contact between the at least one moving contact piece and the at least one fixed contact piece. The screen is disposed between the at least one fixed contact piece and the at least one moving contact piece. | 01-08-2009 |
20110199717 | ELECTRIC POWER DISTRIBUTION ARRANGEMENT AND A SWITCHGEAR PROVIDED THEREWITH - An electric power distribution arrangement having an electric conductor for carrying a high voltage, a first pair of bodies provided on opposite sides of the conductor as seen in a first direction cross-wise to a longitudinal axis of the conductor, and a second pair of bodies provided on opposite sides of the conductor as seen in a second direction cross-wise to the longitudinal axis. The bodies of the first and second pair of bodies are arranged to be electrically disconnected from the conductor, and the spacing between the bodies of the first pair is larger than the spacing between the bodies of the second pair. At least one of the bodies of at least one of the first and second pair comprises a second current conductor, and at least one of the bodies of at least one of the first and second pair comprises a wall element of an encapsulation inside which the conductor is arranged. In a region in which the conductor is surrounded by the first pair and second pair, the conductor has a substantially oval or substantially elliptical shaped outer periphery, and the cross section of the conductor has a larger dimension in the first direction than in the second direction. | 08-18-2011 |
20110226528 | Switch Device And A Switchgear Provided Therewith - A switch device including a bus bar, and a switch knife, wherein the knife is arranged so as to pivot around an axis perpendicular to a longitudinal axis of the bus bar. The bus bar presents a projection which is an integrated part of the bus bar, and the knife is pivotable to a first position, in which it directly contacts said projection, and to a second position in which it is removed from contact with said projection. | 09-22-2011 |
20110304957 | Apparatus For Electric Power Distribution - An apparatus, such as a metering panel, for electric power distribution. An enclosure having an access opening defining an interior space, at least two electrical components for separate phases of electricity. The two components located within the enclosure and spaced laterally apart, at least one electrically insulating barrier panel, movable between at least two guided positions, a working position within the enclosure and between the components and an access position displaced from the components. | 12-15-2011 |
20120178293 | Device For Electric Connection, A Method For Producing Such A Device, And An Electric Installation - A device for electric connection to an energy supply conductor for medium and/or high voltage having a voltage-carrying element with an outer periphery, and a tubular outer shell with an inner periphery, the outer shell being formed by a polymer, and along at least a part of the axial extension of the element the outer shell extends axially with a space between its inner periphery and the outer periphery of the element, at least along a section of said part of the axial extension of the element the space is filled with a filler of an electrically insulating material other than that of the outer shell. An electric installation including the device, and a method for producing the device. | 07-12-2012 |
20140097069 | Switching Device And A Switchgear - A switching device including a breaker electrically connectable to an electrical conductor, and an at least partially electrically conductive housing to which the breaker is mounted, the housing having an outer surface. The breaker includes an electrically conductive first contact and an electrically conductive second contact, the second contact being movable and in relation to the first contact and in relation to the housing, and when the first and second contacts are in contact the breaker is in a closed position, and when the first and second contacts are separated the breaker is in an open position. The switching device is arranged to provide a current path between the breaker and the electrical conductor, and the housing houses a guiding member for operating the second contact, the guiding member being movable in relation to the housing, wherein the guiding member includes a biasing assembly. | 04-10-2014 |
20140104758 | Switching Device And A Switchgear - A switching device for electric power distribution, includes a breaker that is electrically connectable to a conductor, and an electrically conductive housing to which the breaker is mounted. The device provides a current path between the breaker and the conductor. The housing houses at least one guiding member for operating the breaker and a first part of the current path, the first part being electrically connected to the breaker. The device also includes a switch for electrically connecting the breaker to the conductor, the switch having a switch element movable to a first position where the switch element is connected to the first part and the conductor, movable to a second position where the switch element is disconnected from the conductor and connected to the first part and a grounded element, and movable to a third position where the switch element is disconnected from the conductor and the grounded element. | 04-17-2014 |
20160049775 | Knife Switch, A Switching Device Comprising A Knife Switch And A Switchgear - A knife switch including an operator device for moving a contact knife between a first open position and a second position in electrical contact with a contact element. A free end of the contact knife provided with a dynamic electric field control device including an electrically conductive element. A switching device including a two-position switch including an at least partly electrically conductive housing, a three-position switch including the knife switch for connecting the two-position switch to a first electric conductor, wherein the at least partially electrically conductive housing is connected to a second electric conductor. A switchgear including switching devices. | 02-18-2016 |
20160064171 | Switch Assembly, A Switching Device Comprising A Switch Assembly, A Switchgear Comprising A Switching Device And A Method For Cooling - A switch assembly including a vacuum switch mounted to an at least partly electrically conductive housing, and a holder for a vacuum bottle. The housing includes at least one gas entry opening at a lower end of the housing and at least one gas exit opening at an upper end of the housing, and a first free heat convection path between the openings to provide cooling. A second free heat convection path may be provided in a free space between the holder and vacuum bottle. A switching device for connecting the vacuum switch to a second electric conductor. An electric power distribution switchgear, encapsulating at least one three-phase module including a switching device. | 03-03-2016 |
Patent application number | Description | Published |
20140112573 | Systems and Methods for Marking Images for Three-Dimensional Image Generation - Methods and systems for image marking and generation of a three-dimensional (3D) image of an object are described. In an example, a computing device may be configured to receive a first set of images of an object that capture details of the object. The computing device may also be configured to receive a second set of images that include markings projected on the object and that are indexed to correspond to images of the first set of images. The computing device may be configured to spatially align images of the second set of images based on the markings projected on the object and determine respective images of the first set of images corresponding to spatially aligned images of the second set of images. The computing device may then generate a 3D image of the object from the respective images of the first set of images. | 04-24-2014 |
20140253546 | Side-by-Side and Synchronized Displays for Three-Dimensional (3D) Object Data Models - Methods and systems for interacting with multiple three-dimensional (3D) object data models are provided. An example method may involve providing to a display device for display a first 3D object data model and a second 3D object data model. Information associated with a modification to the first 3D object data model may be received. Based on the received information, a same change may be applied to the first 3D object data model and applied to the second 3D object data model to obtain a first modified 3D object data model and a second modified 3D object data model. According to the method, the first modified 3D object data model and the second modified 3D object data model may be provided to the display device for substantially simultaneous display. | 09-11-2014 |
20140340398 | Encoding and Compressing Three-Dimensional (3D) Object Data Models - Methods and systems for encoding and compressing 3D object data models are provided. An example method may involve receiving 3D mesh data for an object that includes geometry coordinates for a surface of the object. Additionally, material properties may be associated with the geometry coordinates. The method may also include identifying multiple portions of the mesh data based on the material properties associated with the geometry coordinates. For example, a given group of adjacent geometry coordinates having common material properties may be identified as a given portion. For at least some of the identified portions of the mesh data, the method may further include encoding information related to an identified portion of the mesh data and compressing the encoded information into a file of compressed geometric data. | 11-20-2014 |
20150145891 | Methods and Systems for Viewing a Three-Dimensional (3D) Virtual Object - Instructions indicative of changing a view of a virtual object may be received by a device. At least a portion of the virtual object may be viewable from a viewpoint that is at a given distance from a surface of the virtual object. The device may cause a change of the view along a rotational path around the virtual object in response to the receipt of the instructions based on the given distance being greater than a threshold distance. The device may cause a change of the view along a translational path indicative of a shape of the surface of the virtual object in response to the receipt of the instructions based on the given distance being less than the threshold distance. | 05-28-2015 |