Schultz, MA
Alexandra Leewon Schultz, Cambridge, MA US
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20150142890 | UNBALANCED MAPPING BETWEEN DESKTOP AND MOBILE PAGES - A collaboration service is disclosed that hosts various collaboration sites. Each of the sites includes desktop pages and mobile pages. A routing service redirects mobile requests for the desktop pages to the mobile pages in accordance with a desktop-to-mobile mapping that defines an unbalanced correspondence between the desktop pages and the mobile pages. The routing service also redirects desktop requests for the mobile pages to the desktop pages in accordance with a mobile-to-desktop mapping that defines a balanced correspondence between them desktop pages and the mobile pages. | 05-21-2015 |
20150143227 | ENHANCED EVENT HANDLER ATTACHMENT - Systems, software, and methods are disclosed herein for implementing a template rendering engine that facilities enhanced event handler attachment when executed by a processing system in the context of a browser application. The template rendering engine examines hypertext markup language (HTML) code downloaded to the browser for templates encoded in the HTML code. When a template is encountered in the HTML code, the template rendering engine examines the template for event handling information indicative of at least an element to render in a web page and an event handler to attach to the element in the web page. The template rendering engine then produces new HTML code for the browser to consume when rendering the web page, the new HTML code comprising the element and the event handler attached to the element. | 05-21-2015 |
Christian P. Schultz, Beverly, MA US
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20100232667 | System for Detecting Malignant Lymph Nodes Using an MR Imaging Device - A system detects malignant lymph nodes using an MR imaging device, for, in the absence of a contrast agent, acquiring in a patient anatomical volume of interest including lymph nodes, (a) a first image using a variable flip angle, lymph node enhanced contrast, MR image acquisition process, (b) a second image using a susceptibility weighting imaging acquisition process and (c) a third image using a diffusion weighting imaging acquisition process. In the presence of a contrast agent absorbed by benign lymph nodes, MR imaging device acquires in the patient anatomical volume of interest, (d) a fourth image using a susceptibility weighting imaging acquisition process. A display processor processes data representing the first, second, third and fourth images for display of malignant and benign lymph nodes on a reproduction device. | 09-16-2010 |
20120186988 | METHOD FOR PRODUCING A RADIOACTIVELY MARKED CARBOXYLATE - A method produces a radioactively marked carboxylate, at least one precursor molecule of the carboxylate being prepared in a solvent including a conductive salt. Radioactively marked carbon dioxide is fed into the solvent. The precursor molecule is electrochemically reacted with the radioactively marked carbon dioxide to form the radioactively marked carboxylate. The radioactively marked carbon dioxide is completely dissolved in the solvent when the precursor molecule is reacted. The radioactively marked carbon dioxide is used for electrochemically synthesizing a radioactively marked carboxylate, the carbon dioxide being completely dissolved in a solvent during synthesis. A microstructure is used for electrochemically synthesizing the radioactively marked carboxylate, radioactively marked carbon dioxide being reacted. | 07-26-2012 |
20130225416 | ELECTRONIC SEQUENCING - A method for sequencing nucleic acid molecules a) amplifies nucleic acid molecules and b) sequences the amplified nucleic acid molecules. Steps (a) and (b) are carried out on an array of field effect transistor (FET) sensor elements, comprising an array of nanowires. Within the array, each FET may include at least one nanowire, or one each FETs can lie between two nanowires, or one nanowire of a nanowire pair is a nanowire FET, with nucleic acids bound to a nanowire surface. A chip includes one or more arrays of field effect transistor sensor elements. A kit for sequencing nucleic acid molecules, may include one or more amplifying reagents or sequencing reagents. | 08-29-2013 |
20130245389 | Learning Patient Monitoring and Intervention System - A patient monitoring and intervention system, comprises an interface for receiving data representing multiple different parameters from multiple different sensors, comprising sensors in a patient bed and attached to a patient including, a heart rate sensor, a respiration sensor and a pressure sensor indicating bed pressure points. A learning processor determines a normal range for a set of the different received patient parameters for the patient by recording the patient parameter values over a time period and analyzing the recorded parameter values to determine their range. A data processor determines if the set of different received patient parameters exceeds the determined normal range and in response to this determination and in response to the type of parameters in the set and medical record information of the patient, initiates adjustment of a patient bed and at least one of, (a) changes medication administered to a patient and (b) alerts a worker of the patient parameter change. | 09-19-2013 |
Dale M. Schultz, Middlesex, MA US
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20150331785 | Pre-translation testing of bi-directional language display - A method for testing the display of bi-directional language script prior to translation in an application under test can include using unidirectional glyphs with shaping indicators to simulate right-to-left characters. The using step can include reversing an ordering of a first set of unidirectional text characters in an input string and mapping the unidirectional text characters to right-to-left code points in a bi-directional language code page to produce a pseudo-translated string. Multiple unidirectional language glyphs can be loaded where each corresponds to a same one of the right-to-left character code points as had been used to produce the pseudo-translation. The pseudo-translation and the glyphs can be combined to simulate right-to-left character rendering in the application under test such the resultant output is visually similar to the input string. Finally, the glyphs can include character shaping indicia such that a resultant output allows for the detection of shaping errors. | 11-19-2015 |
Daniel Schultz, Somerville, MA US
Patent application number | Description | Published |
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20120304062 | REFERENCING CONTENT VIA TEXT CAPTIONS - Improved techniques involve copying text occupying, within a browser application, a selected portion of a transcript associated with the content and, in response to the copying, augmenting the copied text with a direct link to the particular video frame from which particular spoken text begins within the video content. The particular spoken text begins within a particular text caption which corresponds to a timestamp, and the beginning of the copied text occupies the particular text caption. The augmenting of the copied text occurs before the copied text is placed within a buffer in memory reserved for copied data. The contents of the buffer then include the copied text and the direct link to the particular video frame. | 11-29-2012 |
David Andrew Schultz, Cambridge, MA US
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20090240987 | TEST AMPLIFICATION FOR DATACENTER APPLICATIONS VIA MODEL CHECKING - Systems and methods are provided to determine execution errors in distributed computing environments. In an illustrative implementation, a computing environment comprises a test amplification engine and at least one instruction set to instruct the test amplification engine to process data representative of a request to perform a test for one or more execution errors in an distributed computing environment according to a selected execution error testing paradigm dependent on identifying critical sources of non-determinism for execution within the exemplary distributed computing environment. In an illustrative operation, a participating distributed computing environment operator (e.g., programmer) can cooperate with the test amplification engine to select an existing unit or integration test, instrument sources of non-determinism and to select one or more instrumentations for the unit or integration test for execution in the exemplary distributed computing environment to elicit the occurrence of one or more execution errors. | 09-24-2009 |
Eric Schultz, North Andover, MA US
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20100142850 | System, method, and product for scanning of biological materials - An embodiment of a scanning system is described including optical elements that direct an excitation beam at a probe array, detectors that receive reflected intensity data responsive to the excitation beam, where the reflected intensity data is responsive to a focusing distance between an optical element and the probe array, a transport frame that adjusts the focusing distance in a direction with respect to the probe array, an auto-focuser that determines a best plane of focus based upon characteristics of the reflected intensity data of at least two focusing distances where the detectors further receive pixel intensity values based upon detected emissions from a plurality of probe features disposed on the probe array at the best plane of focus, and an image generator that associates each of the pixel intensity values with at least one image pixel position of a probe array based upon one or more position correction values. | 06-10-2010 |
20110243411 | System, method, and product for scanning of biological materials - An embodiment of a scanning system is described including optical elements that direct an excitation beam at a probe array, detectors that receive reflected intensity data responsive to the excitation beam, where the reflected intensity data is responsive to a focusing distance between an optical element and the probe array, a transport frame that adjusts the focusing distance in a direction with respect to the probe array, an auto-focuser that determines a best plane of focus based upon characteristics of the reflected intensity data of at least two focusing distances where the detectors further receive pixel intensity values based upon detected emissions from a plurality of probe features disposed on the probe array at the best plane of focus, and an image generator that associates each of the pixel intensity values with at least one image pixel position of a probe array based upon one or more position correction values. | 10-06-2011 |
20120235016 | System, Method, and Product for Scanning of Biological Materials - An embodiment of a scanning system is described including optical elements that direct an excitation beam at a probe array, detectors that receive reflected intensity data responsive to the excitation beam, where the reflected intensity data is responsive to a focusing distance between an optical element and the probe array, a transport frame that adjusts the focusing distance in a direction with respect to the probe array, an auto-focuser that determines a best plane of focus based upon characteristics of the reflected intensity data of at least two focusing distances where the detectors further receive pixel intensity values based upon detected emissions from a plurality of probe features disposed on the probe array at the best plane of focus, and an image generator that associates each of the pixel intensity values with at least one image pixel position of a probe array based upon one or more position correction values. | 09-20-2012 |
Eric M. Schultz, Worcester, MA US
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20080271384 | CONDITIONING TOOLS AND TECHNIQUES FOR CHEMICAL MECHANICAL PLANARIZATION - Tools for conditioning chemical mechanical planarization (CMP) pads comprise a substrate with abrasive particles coupled to at least one surface. The tools can have various particle and bond configurations. For instance, abrasive particles may be bonded (e.g., brazed or other metal bond technique) to one side, or to front and back sides. Alternatively, abrasive particles are bonded to a front side, and filler particles coupled to a back side. The abrasive particles can form a pattern (e.g., hexagonal) and have particle sizes that are sufficiently small to penetrate pores of a CMP pad during conditioning, leading to fewer defects on wafers polished with the conditioned CMP pad. Grain bonding can be accomplished using brazing films, although other metal bonds may be used as well. Also, balanced bond material (e.g., braze on both sides) allows for low out-of-flatness value. | 11-06-2008 |
20120060426 | Conditioning Tools and Techniques for Chemical Mechanical Planarization - Tools for conditioning chemical mechanical planarization (CMP) pads comprise a substrate with abrasive particles coupled to at least one surface. The tools can have various particle and bond configurations. For instance, abrasive particles may be bonded (e.g., brazed or other metal bond technique) to one side, or to front and back sides. Alternatively, abrasive particles are bonded to a front side, and filler particles coupled to a back side. The abrasive particles can form a pattern (e.g., hexagonal) and have particle sizes that are sufficiently small to penetrate pores of a CMP pad during conditioning, leading to fewer defects on wafers polished with the conditioned CMP pad. Grain bonding can be accomplished using brazing films, although other metal bonds may be used as well. Also, balanced bond material (e.g., braze on both sides) allows for low out-of-flatness value. | 03-15-2012 |
Eric V. Schultz, Boston, MA US
Patent application number | Description | Published |
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20080306956 | METHOD AND SYSTEM FOR DEVELOPING USER PROFILE ON A NETWORK - In an on-line networking community, a method and corresponding system develops detailed user profiles using basic information provided by the user. In one example embodiment, a web server accepts user submitted information from a user and correlates the user submitted information with available databases to retrieve supplemental information about the individual user. Using the supplemental information, the system creates and outputs for community viewing a compound user profile. | 12-11-2008 |
Eric Vaughn Schultz, Newton, MA US
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20100229045 | Computer Method and Apparatus Providing Invocation of Device-Specific Application Through a Generic HTTP Link - A computer method and system processes and handles hypertext-type links by converting client device-independent URLs to respective device-dependent URLs. This enables invocation of device-specific applications through a generic HTTP link. The HTTP link may be embedded in an email, SMS, web-page or similar communication documents or files. | 09-09-2010 |
Joel Henry Schultz, Newtonville, MA US
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20100148895 | Niobium-Tin Superconducting Coil | 06-17-2010 |
20110193666 | Niobium-Tin Superconducting Coil | 08-11-2011 |
20120142538 | Superconducting Coil - A superconducting coil includes (a) a plurality of windings of a coil comprising high-temperature superconductors and (b) an electrically conductive channel in which the high-temperature superconductors are mounted. The high-temperature superconductors can comprise at least one of the following: Ba | 06-07-2012 |
Jonathan Schultz, Oxford, MA US
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20100035252 | Methods for sequencing individual nucleic acids under tension - The invention provides apparatuses and methods of use thereof for sequencing nucleic acids subjected to a force, and thus considered under tension. The methods may employ but are not dependent upon incorporation of extrinsically detectably labeled nucleotides. | 02-11-2010 |
20100300559 | FLUIDICS SYSTEM FOR SEQUENTIAL DELIVERY OF REAGENTS - The invention provides a passive fluidics circuit for directing different fluids to a common volume, such as a reaction chamber or flow cell, without intermixing or cross contamination. The direction and rate of flow through junctions, nodes and passages of the fluidics circuit are controlled by the states of upstream valves (e.g. opened or closed), differential fluid pressures at circuit inlets or upstream reservoirs, flow path resistances, and the like. Free diffusion or leakage of fluids from unselected inlets into the common outlet or other inlets at junctions or nodes is prevented by the flow of the selected inlet fluid, a portion of which sweeps by the inlets of unselected fluids and exits the fluidics circuit by waste ports, thereby creating a barrier against undesired intermixing with the outlet flow through leakage or diffusion. The invention is particularly advantageous in apparatus for performing sensitive multistep reactions, such as pH-based DNA sequencing reactions. | 12-02-2010 |
20100300895 | APPARATUS AND METHODS FOR PERFORMING ELECTROCHEMICAL REACTIONS - The invention is directed to apparatus and methods for delivering multiple reagents to, and monitoring, a plurality of analytical reactions carried out on a large-scale array of electronic sensors underminimal noise conditions. In one aspect, the invention provides method of improving signal-to-noise ratios of output signals from the electronic sensors sensing analytes or reaction byproducts by subtracting an average of output signals measured from neighboring sensors where analyte or reaction byproducts are absent. In other aspects, the invention provides an array of electronic sensors integrated with a microwell array for confining analytes and/or particles for analytical reactions and a method for identifying microwells containing analytes and/or particles by passing a sensor-active reagent over the array and correlating sensor response times to the presence or absence of analytes or particles. Such detection of analyte- or particle-containing microwells may be used as a step in additional noise reduction methods. | 12-02-2010 |
20110217697 | METHODS AND APPARATUS FOR MEASURING ANALYTES USING LARGE SCALE FET ARRAYS - Methods and apparatus relating to very large scale FET arrays for analyte measurements. ChemFET (e.g., ISFET) arrays may be fabricated using conventional CMOS processing techniques based on improved FET pixel and array designs that increase measurement sensitivity and accuracy, and at the same time facilitate significantly small pixel sizes and dense arrays. Improved array control techniques provide for rapid data acquisition from large and dense arrays. Such arrays may be employed to detect a presence and/or concentration changes of various analyte types in a wide variety of chemical and/or biological processes. In one example, chemFET arrays facilitate DNA sequencing techniques based on monitoring changes in the concentration of inorganic pyrophosphate (PPi), hydrogen ions, and nucleotide triphosphates. | 09-08-2011 |
20110250603 | Methods for Sequencing Individual Nucleic Acids Under Tension - The invention provides apparatuses and methods of use thereof for sequencing nucleic acids subjected to a force, and thus considered under tension. The methods may employ but are not dependent upon incorporation of extrinsically detectably labeled nucleotides. | 10-13-2011 |
20110250700 | Methods for Sequencing Individual Nucleic Acids Under Tension - The invention provides apparatuses and methods of use thereof for sequencing nucleic acids subjected to a force, and thus considered under tension. The methods may employ but are not dependent upon incorporation of extrinsically detectably labeled nucleotides. | 10-13-2011 |
20110251078 | Methods for Sequencing Individual Nucleic Acids Under Tension - The invention provides apparatuses and methods of use thereof for sequencing nucleic acids subjected to a force, and thus considered under tension. The methods may employ but are not dependent upon incorporation of extrinsically detectably labeled nucleotides. | 10-13-2011 |
20110251110 | Methods for Sequencing Individual Nucleic Acids Under Tension - The invention provides apparatuses and methods of use thereof for sequencing nucleic acids subjected to a force, and thus considered under tension. The methods may employ but are not dependent upon incorporation of extrinsically detectably labeled nucleotides. | 10-13-2011 |
20110263463 | INTEGRATED SENSOR ARRAYS FOR BIOLOGICAL AND CHEMICAL ANALYSIS - The invention is directed to apparatus and chips comprising a large scale chemical field effect transistor arrays that include an array of sample-retaining regions capable of retaining a chemical or biological sample from a sample fluid for analysis. In one aspect such transistor arrays have a pitch of 10 μm or less and each sample-retaining region is positioned on at least one chemical field effect transistor which is configured to generate at least one output signal related to a characteristic of a chemical or biological sample in such sample-retaining region. In one embodiment, the characteristic of said chemical or biological sample is a concentration of a charged species and wherein each of said chemical field effect transistors is an ion-sensitive field effect transistor having a floating gate with a dielectric layer on a surface thereof, the dielectric layer contacting said sample fluid and being capable of accumulating charge in proportion to a concentration of the charged species in said sample fluid. In one embodiment such charged species is a hydrogen ion such that the sensors measure changes in pH of the sample fluid in or adjacent to the sample-retaining region thereof. Apparatus and chips of the invention may be adapted for large scale pH-based DNA sequencing and other bioscience and biomedical applications. | 10-27-2011 |
20120035062 | ALTERNATIVE NUCLEOTIDE FLOWS IN SEQUENCING-BY-SYNTHESIS METHODS - A method for sequencing a polynucleotide strand by using sequencing-by-synthesis techniques. To address the problem of incomplete extension (IE) and/or carry forward (CF) errors that can occur in sequencing-by-synthesis reactions, an alternative flow ordering of dNTPs is used. In contrast to conventional flow orderings, the dNTPs are flowed in an ordering that is not a continuous repeat of an ordering of the four different dNTPs. This alternate flow ordering may reduce the loss of phasic synchrony in the population of template polynucleotide strands that result from IE and/or CF errors. | 02-09-2012 |
20120073667 | FLUIDICS SYSTEM FOR SEQUENTIAL DELIVERY OF REAGENTS - The invention provides a passive fluidics circuit for directing different fluids to a common volume, such as a reaction chamber or flow cell, without intermixing or cross contamination. The direction and rate of flow through junctions, nodes and passages of the fluidics circuit are controlled by the states of upstream valves (e.g. opened or closed), differential fluid pressures at circuit inlets or upstream reservoirs, flow path resistances, and the like. Free diffusion or leakage of fluids from unselected inlets into the common outlet or other inlets at junctions or nodes is prevented by the flow of the selected inlet fluid, a portion of which sweeps by the inlets of unselected fluids and exits the fluidics circuit by waste ports, thereby creating a barrier against undesired intermixing with the outlet flow through leakage or diffusion. The invention is particularly advantageous in apparatus for performing sensitive multistep reactions, such as pH-based DNA sequencing reactions. | 03-29-2012 |
20120074165 | FLUIDICS SYSTEM FOR SEQUENTIAL DELIVERY OF REAGENTS - The invention provides a passive fluidics circuit for directing different fluids to a common volume, such as a reaction chamber or flow cell, without intermixing or cross contamination. The direction and rate of flow through junctions, nodes and passages of the fluidics circuit are controlled by the states of upstream valves (e.g. opened or closed), differential fluid pressures at circuit inlets or upstream reservoirs, flow path resistances, and the like. Free diffusion or leakage of fluids from unselected inlets into the common outlet or other inlets at junctions or nodes is prevented by the flow of the selected inlet fluid, a portion of which sweeps by the inlets of unselected fluids and exits the fluidics circuit by waste ports, thereby creating a barrier against undesired intermixing with the outlet flow through leakage or diffusion. | 03-29-2012 |
20120172241 | MODELS FOR ANALYZING DATA FROM SEQUENCING-BY-SYNTHESIS OPERATIONS - Mathematical models for the analysis of signal data generated by sequencing of a polynucleotide strand using a pH-based method of detecting nucleotide incorporation(s). In an embodiment, the measured output signal from the reaction confinement region of a reactor array is mathematically modeled. The output signal may be modeled as a linear combination of one or more signal components, including a background signal component. This model is solved to determine the nucleotide incorporation signal. In another embodiment, the incorporation signal from the reaction confinement region of a reactor array is mathematically modeled. | 07-05-2012 |
20120247977 | METHODS AND APPARATUS FOR MEASURING ANALYTES USING LARGE SCALE FET ARRAYS - Methods and apparatus relating to very large scale FET arrays for analyte measurements. ChemFET (e.g., ISFET) arrays may be fabricated using conventional CMOS processing techniques based on improved FET pixel and array designs that increase measurement sensitivity and accuracy, and at the same time facilitate significantly small pixel sizes and dense arrays. Improved array control techniques provide for rapid data acquisition from large and dense arrays. Such arrays may be employed to detect a presence and/or concentration changes of various analyte types in a wide variety of chemical and/or biological processes. In one example, chemFET arrays facilitate DNA sequencing techniques based on monitoring changes in the concentration of inorganic pyrophosphate (PPi), hydrogen ions, and nucleotide triphosphates. | 10-04-2012 |
20120258516 | System and Methods for Making and Processing Emulsions - An automated on-touch template bead preparation system is provided and includes a membrane-based emulsion generation subsystems, an emulsion PCR (ePCR) thermocycling plate and subsystem, and a continuous centrifugation emulsion breaking and templated bead collection subsystem. The emulsion generation subsystem provides uniformity in the preparation of an inverse emulsion and may be used to create large or small volume inverse emulsions rapidly and reproducibly. An emulsion-generating device is provided that can supply a continuous stream of an inverse emulsion to a thermocycling subsystem, in automated fashion. The ePCR subsystem can continuously thermocycle an inverse emulsion passed therethrough and includes static temperature zones and a consumable thermocycling plate. The continuous centrifugation subsystem can continuously break a thermally cycled inverse emulsion and collect template beads formed in the aqueous microreactor droplets of the inverse emulsion. | 10-11-2012 |
20120264621 | PHASE-PROTECTING REAGENT FLOW ORDERINGS FOR USE IN SEQUENCING-BY-SYNTHESIS - A method for nucleic acid sequencing includes disposing template polynucleotide strands in defined spaces on a sensor array, at least some of the template polynucleotide strands having a sequencing primer and a polymerase operably bound therewith; exposing the template polynucleotide strands to a series of flows of nucleotide species flowed according to a predetermined ordering; and determining, for each of the series of flows of nucleotide species, how many nucleotide incorporations occurred for that particular flow to determine a predicted sequence of nucleotides corresponding to the template polynucleotide strands, wherein the predetermined ordering (a) is not a series of consecutive repetitions of a 4-flow permutation of four different nucleotide species, (b) is not specifically tailored to a particular combination of a particular template polynucleotide strand to be sequenced and a particular sequencing primer to be used, and (c) comprises a phase-protecting flow ordering. | 10-18-2012 |
20130164789 | System and Methods for Making and Processing Emulsions - An automated template bead preparation system is provided and includes a membrane-based emulsion generation subsystems, a thermal plate and subsystem, and a continuous centrifugation emulsion breaking and templated bead collection subsystem. The emulsion generation subsystem provides uniformity in the preparation of an inverse emulsion and may be used to create large or small volume inverse emulsions rapidly and reproducibly. An emulsion-generating device is provided that can supply a continuous stream of an inverse emulsion to a thermal subsystem, in automated fashion. The thermal subsystem can treat an inverse emulsion passed therethrough. The continuous centrifugation subsystem can continuously break a thermally cycled inverse emulsion and collect template beads formed in the aqueous microreactor droplets of the inverse emulsion. | 06-27-2013 |
20130172201 | ALTERNATIVE NUCLEOTIDE FLOWS IN SEQUENCING-BY-SYNTHESIS METHODS - A method for sequencing a polynucleotide strand by using sequencing-by-synthesis techniques. To address the problem of incomplete extension (IE) and/or carry forward (CF) errors that can occur in sequencing-by-synthesis reactions, an alternative flow ordering of dNTPs is used. In contrast to conventional flow orderings, the dNTPs are flowed in an ordering that is not a continuous repeat of an ordering of the four different dNTPs. This alternate flow ordering may reduce the loss of phasic synchrony in the population of template polynucleotide strands that result from IE and/or CF errors. | 07-04-2013 |
20130280702 | ALTERNATIVE NUCLEOTIDE FLOWS IN SEQUENCING-BY-SYNTHESIS METHODS - A method for sequencing a polynucleotide strand by using sequencing-by-synthesis techniques. To address the problem of incomplete extension (IE) and/or carry forward (CF) errors that can occur in sequencing-by-synthesis reactions, an alternative flow ordering of dNTPs is used. In contrast to conventional flow orderings, the dNTPs are flowed in an ordering that is not a continuous repeat of an ordering of the four different dNTPs. This alternate flow ordering may reduce the loss of phasic synchrony in the population of template polynucleotide strands that result from IE and/or CF errors. | 10-24-2013 |
20130288873 | AMPLIFICATION AND ARRAY LOADING APPARATUS AND METHODS - An apparatus includes a robotic system providing movement in three orthogonal directions to an arm operable to receive a pipette tip and to facilitate movement of fluid into and out of the pipette tip. In addition, the apparatus can include a tray for receiving pipette tips, receptacles for receiving tubes, an apparatus for forming an emulsion, a device for forming particles that include copies of the polynucleotide, a device for enriching the particles and an apparatus for loading such particles onto a sensor array. The apparatus can further include receptacles for holding containers of reagent solutions. Optionally, the robot can include a gripper arm in addition to the pipette receiving arm. | 10-31-2013 |
20130288904 | PHASE-PROTECTING REAGENT FLOW ORDERINGS FOR USE IN SEQUENCING-BY-SYNTHESIS - A method for nucleic acid sequencing includes: disposing a plurality of template polynucleotide strands, sequencing primers, and polymerases in a plurality of defined spaces of a sensor array; exposing template polynucleotide strands to a series of flows of nucleotide species, the series comprising a sequence of random flows; and obtaining, for each of the series of flows of nucleotide species, a signal indicative of how many nucleotide incorporations occurred for that particular flow to determine a predicted sequence of nucleotides corresponding to the template polynucleotide strands. | 10-31-2013 |
20130302932 | METHODS FOR MANUFACTURING HIGH CAPACITANCE MICROWELL STRUCTURES OF CHEMICALLY-SENSITIVE SENSORS - Methods and apparatus relating to FET arrays for monitoring chemical and/or biological reactions such as nucleic acid sequencing-by-synthesis reactions. Some methods provided herein relate to improving signal (and also signal to noise ratio) from released hydrogen ions during nucleic acid sequencing reactions. | 11-14-2013 |
20130324421 | METHODS AND APPARATUS FOR MEASURING ANALYTES USING LARGE SCALE FET ARRAYS - Methods and apparatus relating to very large scale FET arrays for analyte measurements. ChemFET (e.g., ISFET) arrays may be fabricated using conventional CMOS processing techniques based on improved FET pixel and array designs that increase measurement sensitivity and accuracy, and at the same time facilitate significantly small pixel sizes and dense arrays. Improved array control techniques provide for rapid data acquisition from large and dense arrays. Such arrays may be employed to detect a presence and/or concentration changes of various analyte types in a wide variety of chemical and/or biological processes. In one example, chemFET arrays facilitate DNA sequencing techniques based on monitoring changes in the concentration of inorganic pyrophosphate (PPi), hydrogen ions, and nucleotide triphosphates. | 12-05-2013 |
20140031238 | ALTERNATIVE NUCLEOTIDE FLOWS IN SEQUENCING-BY-SYNTHESIS METHODS - A method for sequencing a polynucleotide strand by using sequencing-by-synthesis techniques. To address the problem of incomplete extension (IE) and/or carry forward (CF) errors that can occur in sequencing-by-synthesis reactions, an alternative flow ordering of dNTPs is used. In contrast to conventional flow orderings, the dNTPs are flowed in an ordering that is not a continuous repeat of an ordering of the four different dNTPs. This alternate flow ordering may reduce the loss of phasic synchrony in the population of template polynucleotide strands that result from IE and/or CF errors. | 01-30-2014 |
20140261736 | FLUIDICS SYSTEM FOR SEQUENTIAL DELIVERY OF REAGENTS - The invention provides a passive fluidics circuit for directing different fluids to a common volume, such as a reaction chamber or flow cell, without intermixing or cross contamination. The direction and rate of flow through junctions, nodes and passages of the fluidics circuit are controlled by the states of upstream valves (e.g. opened or closed), differential fluid pressures at circuit inlets or upstream reservoirs, flow path resistances, and the like. Free diffusion or leakage of fluids from unselected inlets into the common outlet or other inlets at junctions or nodes is prevented by the flow of the selected inlet fluid, a portion of which sweeps by the inlets of unselected fluids and exits the fluidics circuit by waste ports, thereby creating a barrier against undesired intermixing with the outlet flow through leakage or diffusion. The invention is particularly advantageous in apparatus for performing sensitive multistep reactions, such as pH-based DNA sequencing reactions. | 09-18-2014 |
20140271402 | FLUIDICS SYSTEM FOR SEQUENTIAL DELIVERY OF REAGENTS - The invention provides a passive fluidics circuit for directing different fluids to a common volume, such as a reaction chamber or flow cell, without intermixing or cross contamination. The direction and rate of flow through junctions, nodes and passages of the fluidics circuit are controlled by the states of upstream valves (e.g. opened or closed), differential fluid pressures at circuit inlets or upstream reservoirs, flow path resistances, and the like. Free diffusion or leakage of fluids from unselected inlets into the common outlet or other inlets at junctions or nodes is prevented by the flow of the selected inlet fluid, a portion of which sweeps by the inlets of unselected fluids and exits the fluidics circuit by waste ports, thereby creating a barrier against undesired intermixing with the outlet flow through leakage or diffusion. The invention is particularly advantageous in apparatus for performing sensitive multistep reactions, such as pH-based DNA sequencing reactions. | 09-18-2014 |
20140336063 | Windowed Sequencing - In one implementation, a method is described. The method includes determining an operational characteristic of sensors of a sensor array. The method further includes selecting a group of sensors in the array based on the operational characteristic of sensors in the group. The method further includes enabling readout of the sensors in the selected group. The method further includes receiving output signals from the enabled sensors, the output signals indicating chemical reactions occurring proximate to the sensors of the sensor array. | 11-13-2014 |
Jonathan C. Schultz, Oxford, MA US
Patent application number | Description | Published |
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20100301398 | METHODS AND APPARATUS FOR MEASURING ANALYTES - Methods and apparatus relating to FET arrays including large FET arrays for monitoring chemical and/or biological reactions such as nucleic acid sequencing-by-synthesis reactions. Some methods provided herein relate to improving signal (and also signal to noise ratio) from released hydrogen ions during nucleic acid sequencing reactions. | 12-02-2010 |
20110248320 | METHODS AND APPARATUS FOR MEASURING ANALYTES - Methods and apparatus relating to FET arrays including large FET arrays for monitoring chemical and/or biological reactions such as nucleic acid sequencing-by-synthesis reactions. Some methods provided herein relate to improving signal (and also signal to noise ratio) from released hydrogen ions during nucleic acid sequencing reactions. | 10-13-2011 |
20120013392 | METHODS AND APPARATUS FOR MEASURING ANALYTES - Methods and apparatus relating to FET arrays including large FET arrays for monitoring chemical and/or biological reactions such as nucleic acid sequencing-by-synthesis reactions. Some methods provided herein relate to improving signal (and also signal to noise ratio) from released hydrogen ions during nucleic acid sequencing reactions. | 01-19-2012 |
Jonathan M. Schultz, Oxford, MA US
Patent application number | Description | Published |
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20140202883 | APPARATUS AND METHODS FOR PERFORMING ELECTROCHEMICAL REACTIONS - The invention is directed to apparatus and methods for delivering multiple reagents to, and monitoring, a plurality of analytical reactions carried out on a large-scale array of electronic sensors under minimal noise conditions. In one aspect, the invention provides method of improving signal-to-noise ratios of output signals from the electronic sensors sensing analytes or reaction byproducts by subtracting an average of output signals measured from neighboring sensors where analyte or reaction byproducts are absent. In other aspects, the invention provides an array of electronic sensors integrated with a microwell array for confining analytes and/or particles for analytical reactions and a method for identifying microwells containing analytes and/or particles by passing a sensor-active reagent over the array and correlating sensor response times to the presence or absence of analytes or particles. Such detection of analyte- or particle-containing microwells may be used as a step in additional noise reduction methods. | 07-24-2014 |
Joshua Schultz, Waltham, MA US
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20090292554 | METHODS AND APPARATUS FOR PLANNING AND MANAGEMENT OF CLINICAL TRIALS - A tool for planning and management of clinical trials. The tool computes a patient enrollment timeline in a clinical trial using multiple factors that bear on the rate of patient enrollment. The factors may be site-dependent factors or may be country-dependent factors. When these factors are applied, different sites may have different rates of enrollment in the same interval. Further, the factors may be time dependent such that even the same sites may have different enrollment rates in different intervals. Once the timeline is created, the tool may use it to calculate a schedule of monitor visits, project trial completion or otherwise generate output used in management of the clinical trial. | 11-26-2009 |
20100114594 | METHODS AND APPARATUS FOR PLANNING AND MANAGEMENT OF CLINICAL TRIALS - A tool for planning and management of clinical trials. The tool computes a patient enrollment timeline in a clinical trial using multiple factors that bear on the rate of patient enrollment. The factors may be site-dependent factors or may be country-dependent factors. When these factors are applied, different sites may have different rates of enrollment in the same interval. Further, the factors may be time dependent such that even the same sites may have different enrollment rates in different intervals. Once the timeline is created, the tool may use it to calculate a schedule of monitor visits, project trial completion or otherwise generate output used in management of the clinical trial. | 05-06-2010 |
Karen A. Schultz, Cambridge, MA US
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20110305881 | ARTICLES HAVING NON-FOULING SURFACES AND PROCESSES FOR PREPARING THE SAME INCLUDING APPLYING A PRIMER COAT - Processes are described herein for preparing medical devices and other articles having a low-fouling surface on a substrate comprising a polymeric surface. The polymeric surface material may possess a range of polymeric backbones and substituents while providing the articles with a highly efficient, biocompatible, and non-fouling surface. The processes involve coating the substrate to conceal or reduce flaws on or in the surface of the medical device or other article substrate, and thereafter forming a grafted polymer layer on the treated substrate surface. | 12-15-2011 |
Karen Ann Schultz, Cambridge, MA US
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20130155370 | SURFACE MODIFIED CONTACT LENSES - Medical devices having a wettable, biocompatible surface are described herein. Processes for producing such devices are also described. | 06-20-2013 |
20130158150 | MULTISTEP UV PROCESS TO CREATE SURFACE MODIFIED CONTACT LENSES - Medical devices having a wettable, biocompatible surface are described herein. Processes for producing such devices are also described. | 06-20-2013 |
20130158211 | IMBIBING PROCESS FOR CONTACT LENS SURFACE MODIFICATION - Medical devices having a wettable, biocompatible surface are described herein. Processes for producing such devices are also described. | 06-20-2013 |
Kenneth Schultz, Lexington, MA US
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20100226495 | Digital readout method and apparatus - A digital focal plane array includes an all-digital readout integrated circuit in combination with a detector array. The readout circuit includes unit cell electronics, orthogonal transfer structures, and data handling structures. The unit cell electronics include an analog to digital converter. Orthogonal transfer structures enable the orthogonal transfer of data among the unit cells. Data handling structures may be configured to operate the digital focal plane array as a data encryptor/decipherer. Data encrypted and deciphered by the digital focal plane array need not be image data. | 09-09-2010 |
20120138774 | FOCAL PLANE ARRAY PROCESSING METHOD AND APPARATUS - A digital focal plane array includes an all-digital readout integrated circuit in combination with a detector array. The readout circuit includes unit cell electronics, orthogonal transfer structures, and data handling structures. The unit cell electronics include an analog to digital converter. Orthogonal transfer structures enable the orthogonal transfer of data among the unit cells. Data handling structures may be configured to operate the digital focal plane array as a data encryptor/decipherer. Data encrypted and deciphered by the digital focal plane array need not be image data. | 06-07-2012 |
20140197303 | FOCAL PLANE ARRAY PROCESSING METHOD AND APPARATUS - A digital focal plane array includes an all-digital readout integrated circuit in combination with a detector array. The readout circuit includes unit cell electronics, orthogonal transfer structures, and data handling structures. The unit cell electronics include an analog to digital converter. Orthogonal transfer structures enable the orthogonal transfer of data among the unit cells. Data handling structures may be configured to operate the digital focal plane array as a data encryptor/decipherer. Data encrypted and deciphered by the digital focal plane array need not be image data. | 07-17-2014 |
Kenneth I. Schultz, Lexington, MA US
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20130003911 | METHODS AND APPARATUS FOR IN-PIXEL FILTERING IN FOCAL PLANE ARRAYS - Digital focal plane arrays (DFPAs) with multiple counters per unit cell can be used to convert analog signals to digital data and to filter the digital data. Exemplary DFPAs include two-dimensional arrays of unit cells, where each unit cell is coupled to a corresponding photodetector in a photodetector array. Each unit cell converts photocurrent from its photodetector to a digital pulse train that is coupled to multiple counters in the unit cell. Each counter in each unit cell can be independently controlled to filter the pulse train by counting up or down and/or by transferring data as desired. For example, a unit cell may perform in-phase/quadrature filtering of homodyne- or heterodyne-detected photocurrent with two counters: a first counter toggled between increment and decrement modes with an in-phase signal and a second counter toggled between increment and decrement modes with a quadrature signal. | 01-03-2013 |
20140321600 | METHODS AND APPARATUS FOR IN-PIXEL FILTERING IN FOCAL PLANE ARRAYS - Digital focal plane arrays (DFPAs) with multiple counters per unit cell can be used to convert analog signals to digital data and to filter the digital data. Exemplary DFPAs include two-dimensional arrays of unit cells, where each unit cell is coupled to a corresponding photodetector in a photodetector array. Each unit cell converts photocurrent from its photodetector to a digital pulse train that is coupled to multiple counters in the unit cell. Each counter in each unit cell can be independently controlled to filter the pulse train by counting up or down and/or by transferring data as desired. For example, a unit cell may perform in-phase/quadrature filtering of homodyne- or heterodyne-detected photocurrent with two counters: a first counter toggled between increment and decrement modes with an in-phase signal and a second counter toggled between increment and decrement modes with a quadrature signal. | 10-30-2014 |
Lawrence R. Schultz, South Lancaster, MA US
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20100274606 | COMPUTER SYSTEM AND METHOD FOR SUPPORTING AN E-COMMERCE ENTERPRISE HAVING ONLINE E-FRANCHISES - In one embodiment, a centralized website may be generated, stored, and executed on servers, where the centralized website has a particular “look and feel” (e.g., a template). In association with granting online e-franchise rights to a secondary entity, a secondary website may be generated, stored, and executed (e.g., on the servers) for the secondary entity and its particular field of endeavor, where each secondary website has the same particular look and feel as the centralized website. Stored content for the secondary website may be managed and monitored to ensure that it (in addition to the business practice of the secondary entity) is operated in accordance with standards set forth by the centralized entity. In this manner, novel e-commerce models may be created and operated, such as a virtual community of associated alliance members that may be accessed by outside users familiar with and confident in the community. | 10-28-2010 |
20110119153 | COMPUTER SYSTEM AND METHOD FOR GENERATING AND SUPPORTING FAIR TRADE RECEIPTS - In one embodiment, a novel “fair trade receipt” may be generated or otherwise supported for products and services found in commerce, such as in e-commerce or conventional in-person commerce. The fair trade receipt may be generated based upon supply-chain disclosures by sellers of the products/services related to fair trade principles. For instance, these disclosures may concern, among other things, the explicit or general nature of the material used, origin of the material, methods of collection, manufacturing methods and techniques, assembly of product parts, method and materials for packaging, shipping and transportation, consequences to the environment, etc. An algorithm used to compile the supply-chain disclosures may then result in a visual indication (e.g., a seal) and/or printed report (e.g., receipt) on the respective product or service criteria produced in advance of sale. | 05-19-2011 |
Michael David Schultz, Lexington, MA US
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20130231373 | HYDROXAMATE-BASED INHIBITORS OF DEACETYLASES - The present teachings relate to compounds of Formula (I): and pharmaceutically acceptable salts, hydrates, esters, and prodrugs thereof, wherein R | 09-05-2013 |
Michael Walter Schultz, West Brookfield, MA US
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20090118437 | Interlayers Comprising Glycerol Based Plasticizer - The present invention includes interlayers and multiple layer glazing panels comprising those interlayers, wherein the interlayers comprise poly(vinyl butyral) and a glycerol based plasticizer. The addition of the glycerol based plasticizer surprisingly results in a plasticized poly(vinyl butyral) layer that is suitable for use in a wide range of multiple layer glazing applications. | 05-07-2009 |
Neil J. Schultz, Arlington, MA US
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20090006523 | METHOD AND SYSTEM FOR PROVIDING XML-BASED ASYNCHRONOUS AND INTERACTIVE FEEDS FOR WEB APPLICATIONS - A system for providing XML-based asynchronous and interactive feeds for Web applications that provides a highly efficient and extensible XML Javascript framework allowing easy insertion of a comment/news feed control into any Web page. The framework allows for reading of any XML format and provides a new and easy way for modifying the look-and-feel of the control via HTML templates with familiar XPath bindings. The rendering performed through the system supports both flat and indented (“threaded”) views for a comment thread. The system improves the parsing speed of incoming XML, and supports a flexible event model for others to develop plug-ins and mashups in the spirit of Web 2.0. | 01-01-2009 |
20110072116 | METHOD AND SYSTEM FOR PROVIDING XML-BASED ASYNCHRONOUS AND INTERACTIVE FEEDS FOR WEB APPLICATIONS - A system for providing XML-based asynchronous and interactive feeds for Web applications that provides a highly efficient and extensible XML Javascript framework allowing easy insertion of a comment/news feed control into any Web page. The framework allows for reading of any XML format and provides a new and easy way for modifying the look-and-feel of the control via HTML templates with familiar XPath bindings. The rendering performed through the system supports both flat and indented (“threaded”) views for a comment thread. The system improves the parsing speed of incoming XML, and supports a flexible event model for others to develop plug-ins and mashups in the spirit of Web 2.0. | 03-24-2011 |