Patent application number | Description | Published |
20090042922 | NOVEL BELACTOSIN DERIVATIVES AS THERAPEUTIC AGENTS/BIOLOGICAL PROBES AND THEIR SYNTHESIS - Derivatives of belactosin and their synthesis are disclosed. In certain embodiments, compounds of the present invention exhibit anti-cancer, antiviral, antibiotic, and/or auto-immune therapeutic abilities. In general, methods of synthesis disclosed herein allow for introduction of a variety of substituents at numerous positions as well as the facile introduction of a beta-lactone ring moiety. The synthetic steps comprise, in preferred embodiments, a tandem Mukaiyama aldol lactonization reaction. Data demonstrating the utility of some of the derivatives as proteasome inhibitors is also disclosed. | 02-12-2009 |
20090062547 | CYCLIC-FUSED BETA-LACTONES AND THEIR SYNTHESIS - The present invention provides a concise synthetic method for generating lactam-fused beta-lactones that feature, in some embodiments, a tertiary fused carbinol, quaternary carbons, and a reactive beta-lactone moiety available for further reactions. The present invention further provides compounds synthesized by this method as well as methods of using these compounds as inhibitors of the proteasome and fatty acid synthase. | 03-05-2009 |
20090124681 | BETA-LACTONE COMPOUNDS - The present invention provides compounds having the general structure A, or a pharmaceutically acceptable derivatives thereof: | 05-14-2009 |
20100173982 | NOVEL METHOD FOR THE ASYMMETRIC SYNTHESIS OF BETA-LACTONE COMPOUNDS - The present invention features methods of treating a cancer in a subject by administering an effective amount of a beta-lactone to the subject. The invention also features methods of inhibiting angiogenesis in a subject by administering an effective amount of an inhibitor of fatty acid synthase to the subject. These methods can be used to treat a variety of cancers and other diseases and conditions. The invention also features methods of identifying beta-lactones and other compounds that can be used in the methods of the invention for the treatment of tumors, inhibition of angiogenesis, and the treatment of diseases and conditions that involve pathological angiogenesis. The invention also features methods of synthesizing beta-lactones and features novel beta-lactone compounds. | 07-08-2010 |
20110053994 | POTENT IMMUNOSUPPRESSIVE AGENTS, DERIVATIVES AND USES - Provided herein include compositions, all related stereoisomers as well as pharmaceutically acceptable salts provided as simplified analogs of pateamine A, in which the analogs generally are devoid of the C3-amino and C5-methyl groups, also referred to as desmethyl, desamino-pateamine A. Suitable analogs provide anticancer and antiproliferative effects in vivo and in vitro by a novel drugs mechanism of action described herein for pateamine A, including inhibition of eIF4A-dependent translation initiation. As with pateamine A, as described herein, suitable analogs cause cell cycle arrest or induce apoptosis in transformed cells. However, toxicity of such compounds to slow growing normal cells is low. In addition, such analogs, like pateamine A, target translation initiation factors and are useful as anticancer and antiproliferative agents in subjects in need thereof. Moreover, the analogs, like pateamine A, are valuable molecular probes for evalutaion of eukaryotic translation initiation and as lead compounds for development of improved anticancer agents. | 03-03-2011 |
20110207154 | METHOD FOR DETERMINATION OF MARINOBUFAGENIN LEVELS AND COMPOUNDS EMPLOYABLE IN SUCH METHOD - The present invention is directed toward a method for determination of marinobufagenin concentration in a body specimen through conjugation of marinobufagenin to a suitable protein, thereby creating a conjugate which will trigger an antibody response in a host. The conjugated marinobufagenin is immunogenic. The antibodies so produced may be employed in an ELISA test to ascertain the concentration of marinobufagenin in a body specimen. A number of unique compounds are created in the process and are disclosed. An ELISA assay may be employed. | 08-25-2011 |
Patent application number | Description | Published |
20090095574 | Restraint Device for Traction Sheaves - A restraint device is disclosed that limits the movement of the cable or rope relative to the traction, thus reducing or eliminating the popping noise associated with the cable or rope snapping back against the traction sheave. In one embodiment, the restraint device comprises a molded component that is fitted to encompass the region of the sheave where separation of the wire rope from the sheave is most likely to occur. The restraint device may be mounted so that it is removable and replaceable with minimal dismantling of the hoist containing the sheave. The restraint device may be reversible so that one restraint device may by used for at least two cycles before being replaced. Indication of the need for replacement may be provided by including a second color material at the depth where wear reaches the allowable limit, thereby providing a visual signal to initiate replacement as seen during service. | 04-16-2009 |
20090159734 | TENSION HOLDER FOR LOAD LIFTING - A rigging, operable to raise and lower the platform, passes through a restraint device comprising a tension holder. The tension holder comprises a first body having a substantially planar face surface and a rear portion having a divot disposed therein. A second body, substantially similar to the first body; and having a substantially planar face surface; is disposed in a substantially facing arrangement with the first body to permit a line to pass between the substantially planar face surfaces. A lever is disposed in the divot of the first body and is operable to draw together the substantially planar face of the first body and the substantially planar face of the second body whereby friction can be selectively applied to the line when the line is disposed between the substantially planar first surface and said substantially planar second surface. | 06-25-2009 |
20110214949 | STABILIZATION DEVICES - A system for stabilizing the vertical motion of an object in a wind power generating tower comprises at least one static guide, and a guide component attached to the object, e.g., an elevator car, constrained to the proximity of the static guide. In addition, at least one further containment, e.g., a wirefix, coupled to the static guide is able to pass through the first containment as the object moves vertically in the tower. Moreover, the further containment is disposed to maintain the static guide in a fixed relationship to a mounting structure, and the further containment is disposed for in-situ attachment. | 09-08-2011 |
20140216169 | GUIDE WIRE TENSION LOSS SENSOR - Systems and devices are described for measuring tension in a guide wire in a tower service lift for ascending and descending wind turbine generator towers. The present disclosure also describes methods for measuring the tension in the guide wire as well as installing a device for measuring the tension in the guide wire. | 08-07-2014 |
20150075295 | GUIDE WIRE TENSION LOSS SENSOR - Systems and devices are described for measuring tension in a guide wire in a tower service lift for ascending and descending wind turbine generator towers. The present disclosure also describes methods for measuring the tension in the guide wire as well as installing a device for measuring the tension in the guide wire. | 03-19-2015 |
Patent application number | Description | Published |
20080308643 | Automatic Temperature Control with Simplified Microprocessor Interface - An automatic temperature control for a washing machine or the like may adopt in a first embodiment a single triac switched between a hot-water valve and cold-water valve by mechanical switch elements to provide for a range of temperature control via a microprocessor receiving a temperature command input. In a second embodiment two triacs may be used to permit a range of temperature controls to be effected by voltage signals generated by low-voltage low current switches implemented on an integrated circuit board. | 12-18-2008 |
20090120135 | METHOD AND APPARATUS FOR UPGRADING WASHING MACHINE WATER EFFICIENCY - A water level control for a washing machine provides an integrated unit that may replace standard mechanical water level controls with a microprocessor-based circuit that may provide for more sophisticated water management in a standard washing machine using a non-microprocessor cycle timer. | 05-14-2009 |
20100181174 | Appliance Control Knob Providing Illuminated Setting Indication - A shaft of a rotary switch, for example, useful as a control for an appliance, such as a washing machine, incorporates an LED at the end of the shaft and projecting light laterally from the shaft to provide an indication of the rotary position of the corresponding knob with respect to printed indicia on a console. The LED may be powered by slip rings incorporated into the rotary switch and communicating directly with line power as controlled by the limiting resistor and the shaft may include a controlled breakage feature providing LED conductors that are recessed within the shaft in the event of shaft breakage to reduce the chance of operator contact with line voltage. | 07-22-2010 |
20110049251 | Automatic Temperature Control with Simplified Microprocessor Interface - An automatic temperature control for a washing machine or the like may adopt in a first embodiment a single triac switched between a hot-water valve and cold-water valve by mechanical switch elements to provide for a range of temperature control via a microprocessor receiving a temperature command input. In a second embodiment two triacs may be used to permit a range of temperature controls to be effected by voltage signals generated by low-voltage low current switches implemented on an integrated circuit board. | 03-03-2011 |