Patent application number | Description | Published |
20150246950 | Chimeric Dystrophin-VSV-G Protein to Treat Dystrophinopathies - A chimeric protein that is a fusion construct of a series of functional domains is used to deliver a therapeutic agent to a human subject suffering from disease. In some embodiments, the chimeric protein includes a therapeutic region, a transportation region, and a cleavage region disposed between the therapeutic region and the transportation region. The transportation region allows the chimeric protein to be moved across a cellular membrane of an affected cell within the subject. Cleavage of the chimeric protein at the cleavage region once within the cell separates the therapeutic region from the transportation region, enabling the therapeutic region to function normally within the cell. The therapeutic region can be effective in the treatment of, for example, muscular dystrophy, diastrophic dysplasia, malignant melanoma, porphyria, alpha-1 antitrypsin deficiency, Aicardi-Goutieres syndrome, cystic fibrosis, progeria, Marfan syndrome, tuberous sclerosis, adrenoleukodystrophy, and the like. | 09-03-2015 |
Patent application number | Description | Published |
20130246334 | SYSTEM AND METHOD FOR PROVIDING DATA PROTECTION WORKFLOWS IN A NETWORK ENVIRONMENT - A method is provided in one example and includes receiving first sets of metadata elements representing objects of an inventory and generating a first summary of a first subset of the objects. The method further includes receiving second sets of metadata elements and corresponding category information representing objects of the first subset that are classified based on a first category and generating a second summary of a second subset of the classified objects. In yet further embodiments, the method includes initiating a protection task for objects of the second subset of the classified objects. In more specific embodiments, the protection task includes applying a remediation policy to the objects of the second subset or registering the objects of the second subset. In yet other embodiments, the second summary includes at least one of a total count and a total size of the objects in the second subset. | 09-19-2013 |
20130246335 | SYSTEM AND METHOD FOR PROVIDING DATA PROTECTION WORKFLOWS IN A NETWORK ENVIRONMENT - A method is provided in one example and includes receiving first sets of metadata elements representing an inventory of objects in a data storage location of a network environment and presenting an inventory view of the objects to a user. The inventory view includes a first summary of the inventory objects. The method further includes receiving a request from the user to manipulate the inventory view based on a first selected dimension group and presenting to the user a manipulated inventory view that includes a second summary of a first subset of the inventory objects. In more specific embodiments, the method includes receiving a request from the user to perform a protection task on objects of the first subset and initiating the protection task. The protection task includes one of applying a remediation policy to the objects of the first subset and registering the objects of the first subset. | 09-19-2013 |
20130246336 | SYSTEM AND METHOD FOR PROVIDING DATA PROTECTION WORKFLOWS IN A NETWORK ENVIRONMENT - A method is provided in one example and includes crawling a storage location of a network environment to identify objects, fetching the identified objects, creating indexes corresponding to the identified objects, and classifying one or more objects of the identified objects based on a first category. The method further includes providing first sets of metadata elements and corresponding first category information representing the classified one or more objects of the identified objects, searching the indexes for a selected group of the classified one or more objects of the identified objects, and classifying one or more objects of the selected group based on a second category. In more specific embodiments, the method includes applying a remediation policy to the classified one or more objects of the selected group. In other more specific embodiments, the method includes registering the classified one or more objects of the selected group. | 09-19-2013 |
20130246431 | SYSTEM AND METHOD FOR PROVIDING DATA PROTECTION WORKFLOWS IN A NETWORK ENVIRONMENT - A method is provided in one example and includes receiving sets of metadata elements and corresponding category information representing objects of a data storage location that are classified based on a category. The method further includes generating a summary of a subset of the classified objects and initiating a protection task for objects of the subset. In more specific embodiments, the protection task includes applying a remediation policy to the objects of the subset. Another protection task includes registering the objects of the subset. In other specific embodiments, the summary includes at least one of a total count and a total size of the objects in the subset. In yet other more specific embodiments, the method includes creating an Online Analytical Processing (OLAP) data structure to represent the sets of metadata elements and the corresponding category information with the summary of the subset being generated from the OLAP data. | 09-19-2013 |
20140164314 | SYSTEM AND METHOD FOR PROVIDING DATA PROTECTION WORKFLOWS IN A NETWORK ENVIRONMENT - A method is provided in one example and includes receiving first sets of metadata elements representing an inventory of objects in a data storage location of a network environment and presenting an inventory view of the objects to a user. The inventory view includes a first summary of the inventory objects. The method further includes receiving a request from the user to manipulate the inventory view based on a first selected dimension group and presenting to the user a manipulated inventory view that includes a second summary of a first subset of the inventory objects. In more specific embodiments, the method includes receiving a request from the user to perform a protection task on objects of the first subset and initiating the protection task. The protection task includes one of applying a remediation policy to the objects of the first subset and registering the objects of the first subset. | 06-12-2014 |
Patent application number | Description | Published |
20080207536 | Antibacterial Agents - The present invention provides acylide derivatives, which can be used as antibacterial agents. Compounds disclosed herein can be used for the treatment or prevention of a condition caused by or contributed to by Gram-positive, Gram-negative or anaerobic bacteria, more particularly against bacterium such as | 08-28-2008 |
20080318878 | Antibacterial Agents - The present invention provides acylide derivatives, which can be used as antibacterial agents. Compounds disclosed herein can be used for treating or preventing conditions caused by or contributed to by Gram-positive, Gram-negative or anaerobic bacteria, more particularly against, for example, Staphylococci, Streptococci, Enterococci, | 12-25-2008 |
20090215764 | Antimicrobial agents - Provided herein are substituted aromatic compounds, which are tRNA synthetase inhibitors, and hence can be used as antimicrobial agents. Compounds described herein can be used for the treatment or prevention of a condition caused by or contributed to by gram positive, gram negative, anaerobic bacteria or fungal organisms, more particularly against bacterium, for example, | 08-27-2009 |
Patent application number | Description | Published |
20110243941 | Identification and Engineering of Antibodies with Variant Fc Regions and Methods of Using Same - The present invention relates to molecules, particularly polypeptides, more particularly immunoglobulins (e.g., antibodies), comprising a variant Fc region, wherein said variant Fc region comprises at least one amino acid modification relative to a wild-type Fc region, which variant Fc region binds FcγRIIIA and/or FcγRIIA with a greater affinity, relative to a comparable molecule comprising the wild-type Fc region. The molecules of the invention are particularly useful in preventing, treating, or ameliorating one or more symptoms associated with a disease, disorder, or infection. The molecules of the invention are particularly useful for the treatment or prevention of a disease or disorder where an enhanced efficacy of effector cell function (e.g., ADCC) mediated by FcγR is desired, e.g., cancer, infectious disease, and in enhancing the therapeutic efficacy of therapeutic antibodies the effect of which is mediated by ADCC. | 10-06-2011 |
20110305714 | Identification and Engineering of Antibodies with Variant Fc Regions and Methods of Using Same - The present invention relates to molecules, particularly polypeptides, more particularly immunoglobulins (e.g., antibodies), comprising a variant Fc region, wherein said variant Fc region comprises at least one amino acid modification relative to a wild-type Fc region, which variant Fc region binds FcγRIIIA and/or FcγRIIA with a greater affinity, relative to a comparable molecule comprising the wild-type Fc region. The molecules of the invention are particularly useful in preventing, treating, or ameliorating one or more symptoms associated with a disease, disorder, or infection. The molecules of the invention are particularly useful for the treatment or prevention of a disease or disorder where an enhanced efficacy of effector cell function (e.g., ADCC) mediated by FcγR is desired, e.g., cancer, infectious disease, and in enhancing the therapeutic efficacy of therapeutic antibodies the effect of which is mediated by ADCC. | 12-15-2011 |
20130202606 | Identification and Engineering of Antibodies with Variant Fc Regions and Methods of Using Same - The present invention relates to molecules, particularly polypeptides, more particularly immunoglobulins (e.g., antibodies), comprising a variant Fc region, wherein said variant Fc region comprises at least one amino acid modification relative to a wild-type Fc region, which variant Fc region binds FcγRIIIA and/or FcγRIIA with a greater affinity, relative to a comparable molecule comprising the wild-type Fc region. The molecules of the invention are particularly useful in preventing, treating, or ameliorating one or more symptoms associated with a disease, disorder, or infection. The molecules of the invention are particularly useful for the treatment or prevention of a disease or disorder where an enhanced efficacy of effector cell function (e.g., ADCC) mediated by FcγR is desired, e.g., cancer, infectious disease, and in enhancing the therapeutic efficacy of therapeutic antibodies the effect of which is mediated by ADCC. | 08-08-2013 |