Patent application number | Description | Published |
20080252038 | BICYCLE FRAME WITH DEVICE CAVITY - A bicycle frame having a cavity constructed to receive a sensor device. The cavity has a shape and a contour that generally matches a shape and a contour of the sensor device. Such a configuration maintains the aerodynamic contour of the frame when the sensor device is positioned in the cavity. An optional plug occupies the cavity when the sensor device is not positioned therein. Preferably, the sensor device is constructed to wirelessly communicate bicycle operation information to a receiver that is remotely located relative to the sensor device. More preferably, the cavity is formed in a fork of the bicycle and the sensor device is configured to monitor operation of a front wheel and wirelessly communicate the operation information to the remote receiver. | 10-16-2008 |
20080303240 | BICYCLE FORK ASSEMBLY WITH INTEGRAL CROWN AND STEER TUBE - A fork assembly for a bicycle that includes a fork crown with an integrally formed steer tube and a pair of fork receiving pockets. The crown and the steer tube are preferably forged of an aluminum material. Each of a pair of fork blades includes a crown end that has a contour that substantially matches a contour of a respective receiving pocket such that each of the pair of fork blades can be bonded to the crown thereby providing a lightweight and robust fork, fork crown, and steer tube assembly. | 12-11-2008 |
20090056495 | BICYCLE HANDLEBAR ASSEMBLY - A bicycle handlebar assembly having a stem portion constructed to engage a stem tube that is rotationally supported by a frame and a handlebar that is co-molded to the stem portion. Preferably, the stem portion and the handlebar are constructed to dissimilar materials. More preferably, the stem portion is constructed to a metal-type material and the handlebar is constructed of a carbon-fiber material. The stem portion and the handlebar are constructed such that the handlebar engages the stem portion and is secured thereto during formation of the handlebar assembly by co-molding. Such a construction provides a bicycle handlebar assembly that is lightweight, robust, and can be efficiently produced. | 03-05-2009 |
20100117330 | Bicycle Forks, Crown, and Steerer Tube Assembly - A fork assembly for a bicycle includes a pair of forks and a steerer tube that extend in generally opposite directions from a fork crown. The assembly includes first and second means for securing the steerer tube to the fork crown. Preferably, the steerer tube is threaded and bonded to the fork crown. The fork crown includes a pair of cavities that each slidably receives a respective fork. Preferably, each fork is formed of a carbon fiber material and has an end whose shape substantially matches a shape of a respective cavity formed in the crown. The forks and crown cavities cooperate to efficiently communicate loads between the forks and the fork crown while maintaining a lightweight and robust fork, fork crown, and steerer tube assembly. | 05-13-2010 |
Patent application number | Description | Published |
20100297207 | QUATERNARY AMMONIUM SALTS AS MICROBE INHIBITORS - The present invention relates to quaternary ammonium salts and their use as mold inhibitors. The quaternary salts can be prepared by a chloride ion-promoted reaction between a tertiary amine and an alcohol or polyol in strong acid solution. The quaternary ammonium salts can be applied to a substrate in order to impart anti-mold properties to the substrate. Preferably, the quaternary ammonium salt compounds are applied to paper substrates in an amount of about 1000 ppm. Preferably, the quaternary ammonium salts compounds are applied as mixtures of more than one quaternary ammonium salt compound. The treated substrate does not require encapsulators, binders, or retention aids. | 11-25-2010 |
20110082194 | Synergistic Anticoagulant Composition - A composition is provided that, when utilized in combination with warfarin, greatly improves the anticoagulant effects of warfarin in mammalian subjects. The composition is a compound having a naphthohydroquinone ring system substantially similar to the ring system of the reduced form of vitamin K | 04-07-2011 |
20120034290 | QUATERNARY AMMONIUM SALTS AS MICROBE INHIBITORS - The present invention relates to quaternary ammonium salts and their use as mold inhibitors. The quaternary salts can be prepared by a chloride ion-promoted reaction between a tertiary amine and an alcohol or polyol in strong acid solution. The quaternary ammonium salts can be applied to a substrate in order to impart anti-mold properties to the substrate. Preferably, the quaternary ammonium salt compounds are applied to paper substrates in an amount of about 1000 ppm. Preferably, the quaternary ammonium salts compounds are applied as mixtures of more than one quaternary ammonium salt compound. The treated substrate does not require encapsulators, binders, or retention aids. | 02-09-2012 |
Patent application number | Description | Published |
20110207799 | Compositions for Targeted Delivery of siRNA - The present invention is directed compositions for targeted delivery of RNA interference (RNAi) polynucleotides to hepatocytes in vivo. Targeted RNAi polynucleotides are administered together with co-targeted delivery polymers. Delivery polymers provide membrane penetration function for movement of the RNAi polynucleotides from outside the cell to inside the cell. Reversible modification provides physiological responsiveness to the delivery polymers. | 08-25-2011 |
20120157509 | GALACTOSE CLUSTER-PHARMACOKINETIC MODULATOR TARGETING MOIETY FOR siRNA - The present invention is directed compositions for targeted delivery of RNA interference (RNAi) polynucleotides to cell in vivo. The pharmacokinetic modulator improve in vivo targeting compared to the targeting ligand alone. Targeting ligand-pharmacokinetic modulator targeting moiety targeted RNAi polynucleotides can be administered in vivo alone or together with co-targeted delivery polymers. | 06-21-2012 |
20120165393 | Peptide-Based In Vivo siRNA Delivery System - The present invention is directed compositions for targeted delivery of RNA interference (RNAi) polynucleotides to hepatocytes in vivo. Targeted RNAi polynucleotides are administered together with co-targeted melittin delivery peptides. Delivery peptides provide membrane penetration function for movement of the RNAi polynucleotides from outside the cell to inside the cell. Reversible modification provides physiological responsiveness to the delivery peptides. | 06-28-2012 |
20120172412 | In Vivo Polynucleotide Delivery Conjugates Having Enzyme Sensitive Linkages - The present invention is directed compositions for delivery of RNA interference (RNAi) polynucleotides to cells in vivo. The compositions comprise amphipathic membrane active polyamines reversibly modified with enzyme cleavable dipeptide-amidobenzyl-carbonate masking agents. Modification masks membrane activity of the polymer while reversibility provides physiological responsiveness. The reversibly modified polyamines (dynamic polyconjugate or DPC) are further covalently linked to an RNAi polynucleotide or co-administered with a targeted RNAi polynucleotide-targeting molecule conjugate. | 07-05-2012 |
20120230938 | Polyconjugates for In Vivo Delivery of Polynucleotides - The present invention is directed to compounds, compositions, and methods useful for delivering polynucleotides or other cell-impermeable molecules to mammalian cells. Described are polyconjugates systems that incorporate targeting, anti-opsonization, anti-aggregation, and transfection activities into small biocompatible in vivo delivery vehicles. The use of multiple reversible or labile linkages connecting component parts provides for physiologically responsive activity modulation. | 09-13-2012 |
20130245091 | Compositions for Targeted Delivery of siRNA - The present invention is directed compositions for targeted delivery of RNA interference (RNAi) polynucleotides to hepatocytes in vivo. Targeted RNAi polynucleotides are administered together with co-targeted delivery polymers. Delivery polymers provide membrane penetration function for movement of the RNAi polynucleotides from outside the cell to inside the cell. Reversible modification provides physiological responsiveness to the delivery polymers. | 09-19-2013 |
20130281658 | Peptide-Based In Vivo siRNA Delivery System - The present invention is directed compositions for targeted delivery of RNA interference (RNAi) polynucleotides to hepatocytes in vivo. Targeted RNAi polynucleotides are administered together with co-targeted melittin delivery peptides. Delivery peptides provide membrane penetration function for movement of the RNAi polynucleotides from outside the cell to inside the cell. Reversible modification provides physiological responsiveness to the delivery peptides. | 10-24-2013 |
20140135380 | Small molecule conjugates for intracellular delivery of nucleic acids - The invention provides use of novel compounds for delivery of nucleic acids, and conjugates of these compounds with nucleic acids. Further novel design criteria for chemically stabilized siRNA particular useful when covalently attached to said compounds and co-administered with a delivery polymer to achieve mRNA knock down in vivo are disclosed therein. | 05-15-2014 |
20140135381 | Small molecule conjugates for intracellular delivery of biologically active compounds - The invention provides novel compounds and conjugates of these compounds useful for the delivery of biologically active substances. Further novel design criteria for chemically stabilized siRNA particular useful when covalently attached to a delivery polymer to achieve in vivo mRNA knock down are disclosed therein. | 05-15-2014 |
20150202298 | Compositions for Targeted Delivery of siRNA - The present invention is directed compositions for targeted delivery of RNA interference (RNAi) polynucleotides to hepatocytes in vivo. Targeted RNAi polynucleotides are administered together with co-targeted delivery polymers. Delivery polymers provide membrane penetration function for movement of the RNAi polynucleotides from outside the cell to inside the cell. Reversible modification provides physiological responsiveness to the delivery polymers. | 07-23-2015 |
20150361427 | Compositions and Methods for Inhibiting Gene Expression of Alpha-1 AntiTrypsin - The invention relates to a RNA interference triggers for inhibiting the expression of an AAT gene through the mechanism of RNA interference. The invention also relates to a pharmaceutical composition comprising the AAT RNAi trigger together with an excipient capable of improving delivery of the RNAi trigger to a liver cell in vivo. Delivery of the AAT RNAi trigger to liver cells in vivo provides for inhibition of AAT gene expression and treatment of alpha 1-antitrypsin deficiency and associated diseases. | 12-17-2015 |
20160102120 | Galactose Cluster-Pharmacokinetic Modulator Targeting Moiety for siRNA - The present invention is directed compositions for targeted delivery of RNA interference (RNAi) polynucleotides to cell in vivo. The pharmacokinetic modulator improve in vivo targeting compared to the targeting ligand alone. Targeting ligand-pharmacokinetic modulator targeting moiety targeted RNAi polynucleotides can be administered in vivo alone or together with co-targeted delivery polymers. | 04-14-2016 |
Patent application number | Description | Published |
20090291174 | HIGH PRESSURE PASTEURIZABLE/ULTRA-HIGH PRESSURE STERILIZABLE FOOD PROCESSING CONTAINER AND METHOD - A method and container capable of withstanding ultra-high pressure sterilization or pasteurization and being used as a retail package. The container includes at least one deformable pressure absorbing fold channel integrally formed therein enabling the container to undergo UHP processing and return substantially to its prior shape. In one embodiment, the container has at least one sidewall with such a fold channel. In a preferred embodiment, the package also has a bottom wall with a fold channel. The container is thermoformed of a sheet that includes at least one oxygen barrier layer and includes a peelable oxygen barrier film covering a container opening. In a preferred method, the container has a plurality of sidewalls with a fold channel therebetween and a bottom with a fold channel thereabout that accommodates compression between 5% and 25% without showing visible damage when subjected to pressures of between 70 ksi and 120 ksi. | 11-26-2009 |
20120111858 | Reclosable Beam Blade Wiper Blade Package - An elongate article holding package for a pre-curved beam blade wiper blade includes a pair of packaging panels joined by a living hinge. In a currently preferred embodiment, the package has two panels joined by a living hinge. A first panel is configured to retain the wiper blade in a substantially straight configuration within a cavity formed in the panel, and the second panel is pivotally connected by the living hinge to be disposed in either a closed or an open position with the first panel. The first panel preferably includes a first channel having a first bottom wall and a second channel disposed in the first bottom wall and in communication with the first channel. The first panel preferably also includes retention fingers to positively retain the wiper blade and recessed sidewall portions to facilitate insertion and extraction of the wiper blade into the first panel. | 05-10-2012 |
20120199598 | Reclosable Wiper Blade Package With Improved Package Closure Arrangement - A reclosable package well suited for holding pre-curved beam-type wiper blades in a package cavity formed in a base that releasably engages with a cover via a reclosable closure arrangement that includes an arrangement of bar snaps each formed of a bar with an elongated bulbous head received in a complementarily configured bar snap pocket during package closure. Each bar includes inclined endwalls that facilitate location and entry of the head into a narrower mouth of the pocket until the head is received in a head-anchoring chamber releasably clamping the bar head in place. The closure arrangement can include an interlocking rib-and-channel arrangement having a rib segment extending along a hinge joining the cover to the base and rib sections extending along end flanges and part of an outer flange that stiffen and strengthen the package while guiding bar snaps into snap-fit engagement during package closure. | 08-09-2012 |
20160001949 | Reclosable Package with Anti Stake Latches - A reclosable package for an article may include a base with a planar floor defining an article-retaining cavity and raised sidewalls extending about the perimeter forming part of the article-retaining cavity with a cover with raised sidewalls coupled to the base configured to move between an open position and a closed position. The sidewalls may form a double wall about the perimeter of the base with a channel that remains open when the cover is disposed in the closed position. A plurality of projections extending from at least one sidewall of at least one of the cover and base and a plurality of notches in at least one sidewall of at least one of the cover and base keep the cover closed as the projections insert into the notches with a snap fit engagement. | 01-07-2016 |
20160001966 | Reclosable Wiper Blade Package - A reclosable wiper blade package for holding a beam-type wiper blade having a wiper blade adapter-receiving cradle of a blade receiving cavity formed in one of a pair of package halves that is configured for snap fit engagement with an adapter of the wiper blade releasably retained in the blade receiving cavity. The cradle can also be configured to locate and orient arms of the wiper blade so they engage a corresponding blade arm seat in a substantially straightened condition orienting the blade on its side. One or both package halves are formed with elongate ribs that can define package sidewalls that can even form at least part of the blade receiving cavity that can have spaced apart rib-strengthening gussets where rib width is narrowed or constricted. | 01-07-2016 |
Patent application number | Description | Published |
20140278642 | Tracking and Processing Requests From Hospitality Customers - Method, system, and computer program product embodiments process requests using a request management system. Defining steps include defining a set of users, each user associated with one or more groups, and defining a list of request types, each request type assigned to at least one group. Each request type defines one or more requests receivable from a customer's mobile device. A further step is receiving a request from a customer's mobile device. The customer's mobile device is configured to connect to the request management system to submit one or more requests defined by the set of request types. Finally, an assigning step assigns the request received from the customer to one or more groups assigned to fulfill the request type that includes the received request. | 09-18-2014 |
20140279199 | Generating Recommendations Based On Hospitality Customer Feedback - Method, system, and computer program product embodiments are disclosed for generating recommendations to hospitality customers. Defining steps include enabling a customer to select a particular business from among one or more businesses at a mobile device utilized by the customer, configuring the customer's mobile device to receive a recommendation from the customer, and providing the recommendation to a user at the particular business for review, wherein the recommendation is selectable for public review by potential customers requesting information about the particular business. | 09-18-2014 |
20140279244 | Receiving and Queuing Requests From Hospitality Customers - System, method, and computer program product embodiments for receiving customer requests use a request management system. An embodiment operates by establishing a connection with a customer's mobile device, obtaining information about the location of the customer's mobile device, providing to the customer's mobile device a set of data describing goods or services currently offered by one or more business locations, receiving from the customer's mobile device a request for a good or service offered by a particular business location, and adding the request to a queue associated with one or more groups assigned to fulfill the request based on the request type. | 09-18-2014 |
20140358735 | Modifying An Application To Display Branding Information Identifying A Particular Business - Method, system, and computer program product embodiments are disclosed for displaying a branded interface. Defining steps enabling a customer to select a particular entity from among one or more entities at a mobile device utilized by the customer, configuring the customer's mobile device to receive display specifications defined by a user associated with the particular entity, receiving the display specifications at the customer's mobile device, and configuring the customer's mobile device to display a branded interface based on the display specifications. | 12-04-2014 |
20150019374 | PROVIDING RECOMMENDATIONS TO CUSTOMERS - Method, system, and computer program product embodiments are disclosed for providing recommendations to customers. Defining steps include establishing a connection with a customer's mobile device, obtaining information about the location of the customer's mobile device, determining recommended goods or services currently offered by one or more business locations, and outputting for display on the customer's mobile device a listing of the recommended goods or services navigable by category or subcategory. | 01-15-2015 |
Patent application number | Description | Published |
20100279403 | DIFFERENTIATION OF PLURIPOTENT CELLS - Provided herein are methods for the in vitro maintenance, expansion, culture, and/or differentiation of pluripotent cells, such as human embryonic stem cells (hESC) or induced pluripotent cells (iPSC), into hematopoietic precursor cells or endothelial cells. The pluripotent cells may be maintained and differentiated under defined conditions; thus, the use of mouse feeder cells or serum is not required in certain embodiments for the differentiation of the pluripotent cells into hematopoietic precursor cells or endothelial cells. The resulting hematopoietic precursor cells may be further differentiated into various myeloid or lymphoid lineages. | 11-04-2010 |
20130210141 | DIFFERENTIATION OF PLURIPOTENT CELLS - Provided herein are methods for the in vitro maintenance, expansion, culture, and/or differentiation of pluripotent cells, such as human embryonic stem cells (hESC) or induced pluripotent cells (iPSC), into hematopoietic precursor cells or endothelial cells. The pluripotent cells may be maintained and differentiated under defined conditions; thus, the use of mouse feeder cells or serum is not required in certain embodiments for the differentiation of the pluripotent cells into hematopoietic precursor cells or endothelial cells. The resulting hematopoietic precursor cells may be further differentiated into various myeloid or lymphoid lineages. | 08-15-2013 |