Patent application number | Description | Published |
20080306819 | SYSTEM AND METHOD FOR SHAPING RELEVANCE SCORES FOR POSITION AUCTIONS - The present invention is directed towards systems and methods for ranking and providing advertisements in a position auction. The method of the present invention comprises receiving a search query and selecting at least one keyword based upon the search query. A list containing at least one keyword based upon the search query is returned and a list comprising at least one bid corresponding to the returned list of keywords is retrieved. A priority score corresponding to each bid is computed and used to rank the list of bids. Advertisements are then provided corresponding to a plurality of the highest ranking bids. | 12-11-2008 |
20120117059 | Ranking Authors in Social Media Systems - The author ranking technique described herein is a technique to rank authors in social media systems along various dimensions, using a variety of statistical methods for utilizing those dimensions. More particularly, the technique ranks authors in social media systems through a combination of statistical techniques that leverage usage metrics, and social and topical graph characteristics. In various exemplary embodiments, the technique can rank author authority by the following: 1) temporal analysis of link sharing in which authority is computed based on a user's propensity to provide early links to web pages that subsequently become popular; 2) topical authority based on the author's links and content updates in specific topic areas; and 3) popularity and influence based on nodal properties of authors. | 05-10-2012 |
20120166931 | SYSTEM AND METHOD FOR GENERATING SOCIAL SUMMARIES - The described implementations relate to communication platforms that are provided over computer networks. One implementation provides a system that can include a storage component configured to store a plurality of communications having a common connector. The system can also include a score computation component that is configured to compute scores reflecting semantic relationships between individual communications from the plurality of communications. The system can also include a summary generation component that is configured to select one or more of the individual communications, based on the scores, and generate a summary of the common connector. The summary can represent the selected individual communications. The system can also include at least one processor configured to execute one or more of the components. | 06-28-2012 |
20140280229 | GENERATING DESCRIPTIONS OF MATCHING RESOURCES BASED ON THE KIND, QUALITY, AND RELEVANCE OF AVAILABLE SOURCES OF INFORMATION ABOUT THE MATCHING RESOURCES - Techniques are provided for generating descriptions of matching resources in a manner that takes into account the kind, quality, and relevance of the available sources of information about the matching resources. For example, after the search engine identifies matching resources based on the query terms, the search engine determines the kinds of available sources of information about each matching resource. For each matching resource, based on the kinds of available sources of information about the matching resource, one of a plurality of processes is selected to generate a description for the matching resource. Using the content-sensitive description generation techniques described herein, a single result set may include abstracts that were generated using several different processes, where the difference in process corresponds to a difference in the kind, quality, and relevance of the available sources of information about each matching resource. | 09-18-2014 |
Patent application number | Description | Published |
20090286246 | Methods for Identifying Compounds that Affect Expression of Cancer-Related Protein Isoforms - Provided herein are methods for screening compounds for their ability to modulate the expression of certain isoforms of proteins that are associated with cancer, such as isoforms of proteins that participate in Wnt signaling in cancer cells. | 11-19-2009 |
20100068708 | Methods for Identifying Compounds that Modulate WNT Signaling in Cancer Cells - Provided herein are methods for screening compounds for their ability to modulate Wnt signaling in cancer cells. | 03-18-2010 |
20100203113 | WNT SIGNALLING INHIBITORS, AND METHODS FOR MAKING AND USING THEM - The invention provides dBHD-based compositions and dBHD analog compositions, and pharmaceutical compositions comprising them, e.g., in the form of liposomes and nanoparticles comprising them, and methods of making and using them. In one embodiment, these dBHD analogs are used to inhibit a dysfunctional stem cell and/or a cancer (tumor) stem cell. | 08-12-2010 |
20100266675 | LIPOPROTEINS, LIPOPEPTIDES AND ANALOGS, AND METHODS FOR MAKING AND USING THEM - The invention provides novel compositions—lipopeptides and analogs, including somocystinamide A, and somocystinamide A variants and analogs, and pharmaceutical compositions, liposomes and nanoparticles comprising them, and methods of making and using them. In one embodiment, these lipopeptides and analogs are used to induce apoptosis in a cell, which can be a normal cell, a dysfunctional cell and/or a cancer (tumor) cell. In alternative embodiments, the compositions of the invention, including the lipopeptides and analogs of the invention, and the pharmaceutical compositions comprising them, are used to treat or ameliorate (including slowing the progression of) normal, dysfunctional (e.g., abnormally proliferating) and/or tumor associated blood vessels, including endothelial and/or capillary cell growth; including neovasculature related to (within, providing a blood supply to) a tumor. | 10-21-2010 |
20110108422 | EX VIVO MULTI-DIMENSIONAL SYSTEM FOR THE SEPARATION AND ISOLATION OF CELLS, VESICLES, NANOPARTICLES AND BIOMARKERS - Devices and techniques are described that involve a combination of multidimensional electrokinetic, dielectrophoretic, electrophoretic and fluidic forces and effects for separating cells, nanovesicles, nanoparticulates and biomarkers (DNA, RNA, antibodies, proteins) in high conductance (ionic) strength biological samples and buffers. In disclosed embodiments, a combination of continuous and/or pulsed dielectrophoretic (DEP) forces, continuous and/or pulsed field DC electrophoretic forces, microelectrophoresis and controlled fluidics are utilized with arrays of electrodes. In particular, the use of chambered DEP devices and of a properly scaled relatively larger electrode array devices that combines fluid, electrophoretic and DEP forces enables both larger and/or clinically relevant volumes of blood, serum, plasma or other samples to be more directly, rapidly and efficiently analyzed. The invention enables the creation of “seamless” sample-to-answer diagnostic systems and devices. The devices and techniques described can also carry out the assisted self-assembly of molecules, polymers, nanocomponents and mesoscale entities into three dimensional higher order structures. | 05-12-2011 |
20140048417 | Ex-Vivo Multi-Dimensional System For The Separation And Isolation Of Cells, Vesicles, Nanoparticles, And Biomarkers - Devices and techniques are described that involve a combination of multidimensional electrokinetic, dielectrophoretic, electrophoretic and fluidic forces and effects for separating cells, nanovesicles, nanoparticulates and biomarkers (DNA, RNA, antibodies, proteins) in high conductance (ionic) strength biological samples and buffers. In disclosed embodiments, a combination of continuous and/or pulsed dielectrophoretic (DEP) forces, continuous and/or pulsed field DC electrophoretic forces, microelectrophoresis and controlled fluidics are utilized with arrays of electrodes. In particular, the use of chambered DEP devices and of a properly scaled relatively larger electrode array devices that combines fluid, electrophoretic and DEP forces enables both larger and/or clinically relevant volumes of blood, serum, plasma or other samples to be more directly, rapidly and efficiently analyzed. The invention enables the creation of “seamless” sample-to-answer diagnostic systems and devices. The devices and techniques described can also carry out the assisted self-assembly of molecules, polymers, nanocomponents and mesoscale entities into three dimensional higher order structures. | 02-20-2014 |
Patent application number | Description | Published |
20080280903 | Apoptosis Inhibitors - The present invention provides compounds that act as selective agents to protect against unintentional cell death or tissue damage and can relieve side effects of cancer treatment such as, for example, oral mucositis, hair loss, diarrhea due to damage to the gastrointestinal epithelium, and myelosuppression. In addition, these compounds can be used to prevent premature cell death when the cell death is caused by signals from damaged cells, for example, signals generated as the result of a traumatic incident or an ischemic episode. | 11-13-2008 |
20090202626 | TREATMENT OF BLADDER DISEASES WITH A TLR7 ACTIVATOR - The invention provides a method for the treatment of superficial bladder cancer and inflammatory diseases of the bladder which employs certain Toll-like Receptor (TLR)-agonists. | 08-13-2009 |
20090324551 | TLR AGONISTS - The present invention provides for TLR agonist conjugates (compounds) and compositions, as well as methods of using them. The compounds of the invention are broad-spectrum, long-lasting, and non-toxic combination of synthetic immunostimulatory agents, which are useful for activating the immune system of a mammal, preferably a human and can help direct the pharmacophore to the receptor within the endosomes of target cells and enhance the signal transduction induced by the pharmacophore. | 12-31-2009 |
20100086918 | Methods for High Sensitivity Detection of Genetic Polymorphisms - Multiplex PCR-based methods for detecting a variant polynucleotide having a nucleotide sequence differing from the wild-type nucleotide sequence of a nucleic acid molecule, wherein the variant polynucleotide is in a sample containing an excess of the wild-type nucleic acid molecule. The methods are particularly useful for detection of deletions from, or translocations and inversions in, genomic DNA. The susceptibility to, diagnosis of, and progression of a disease clinically related to the occurrence of such polymorphisms in an individual may also be confirmed and monitored using the multiplex PCR-based methods or by detecting RNA fusion transcripts in a sample that correspond to previously identified deletions, translocations or inversions in genomic DNA. | 04-08-2010 |
20100210598 | TOLL-LIKE RECEPTOR MODULATORS AND TREATMENT OF DISEASES - Provided herein are small molecule conjugates that are agonists or antagonists of one or more toll-like receptors. | 08-19-2010 |
20110098294 | PURINE ANALOGS - The present invention provides a new patentable class of purine analog compounds, as well as compositions and methods of using them, for example, to prevent or treat various diseases and disorders in human and non-human animals. | 04-28-2011 |
20110306671 | AMIDE DERIVATIVES OF ETHACRYNIC ACID - The invention provides ethacrynic acid derivatives useful to prevent, inhibit or treat a variety of disorders or diseases including cancer and inflammatory disorders. | 12-15-2011 |
20120148660 | CONJUGATES OF SYNTHETIC TLR AGONISTS AND USES THEREFOR - The invention provides TLR agonists and conjugates thereof useful in vaccines and to prevent, inhibit or treat a variety of disorders including pathogen infection and asthma. | 06-14-2012 |
20130156807 | CONJUGATES OF SYNTHETIC TLR AGONISTS AND USES THEREFOR - The invention provides TLR agonists and conjugates thereof useful in vaccines and to prevent, inhibit or treat a variety of disorders including pathogen infection and asthma. | 06-20-2013 |
20130165455 | TLR AGONISTS - The present invention provides for TLR agonist conjugates (compounds) and compositions, as well as methods of using them. The compounds of the invention are broad-spectrum, long-lasting, and non-toxic combination of synthetic immunostimulatory agents, which are useful for activating the immune system of a mammal, preferably a human and can help direct the pharmacophore to the receptor within the endosomes of target cells and enhance the signal transduction induced by the pharmacophore. | 06-27-2013 |
20130190494 | PURINE ANALOGS - The present invention provides a new patentable class of purine analog compounds, as well as compositions and methods of using them, for example, to prevent or treat various diseases and disorders inhuman and non-human animals. | 07-25-2013 |
20130202629 | USES OF PHOSPHOLIPID CONJUGATES OF SYNTHETIC TLR7 AGONISTS - The invention provides uses for phospholipid conjugates of TLR agonists, for instance in vaccines, and to prevent, inhibit or treat a variety of disorders including inflammation, cancer and pathogen, e.g., microbe, infection. | 08-08-2013 |
20140302120 | CONJUGATES OF SYNTHETIC TLR AGONISTS AND USES THEREFOR - The invention provides TLR agonists and conjugates thereof useful in vaccines and to prevent, inhibit or treat a variety of disorders including pathogen infection and asthma. | 10-09-2014 |
20150132342 | NOVEL IMMUNE ACTIVATORS: SUBSTITUTE 4-AMINOQUINAZOLINES - Provided herein are compounds and methods for modulating an immune response in a subject in need thereof. Further provided herein are compounds and methods for modulating a toll-like receptor protein. | 05-14-2015 |
20150197527 | COMPOSITIONS AND METHODS FOR MODULATING TLR4 - Provided herein, inter alia, are methods and compositions for modulating TLR-4. | 07-16-2015 |
20150366962 | SYNTHETIC TLR4 AND TLR7 LIGANDS AS VACCINE ADJUVANTS - This disclosure relates to compositions and methods useful to augment an immune response and methods and compositions for inducing immunogenicity to influenza antigens. | 12-24-2015 |
Patent application number | Description | Published |
20080201188 | Niche-oriented advertising networks platform and methods of operating same - System and methods of constructing and operating a network of advertising networks in support of the real-time selection and distribution of creatives to network connected client computer systems for composited presentation on Web pages served to client computer systems. The network of networks is constructed by associating a plurality of publisher sites with a plurality of advertising networks, with each publisher site associated with one or more advertising networks, and associating a plurality of advertising campaigns with the plurality of advertising networks, with each advertising campaign associated with one or more of the advertising networks and further defined by respective campaign criteria. A campaign prioritization list is produced for each publisher site, generated based on a competitive analysis of respective campaign criteria, including a normalized campaign buy basis, employing a past-performance-based projection of a competitive completion of the advertising campaigns. Advertising creatives are served, in real-time, in response to service requests received from client computer systems, where the advertising creative selection is determined from the campaign prioritization list dependent on the respective publisher site and real-time evaluation of the respective campaign criteria. | 08-21-2008 |
20140333957 | METHOD AND SYSTEM FOR MESSAGE DELIVERY USING A SECURE DEVICE AND SIMPLE OUTPUT WITHOUT THE USE OF A PERSONAL COMPUTER - Communication systems and methods for enhancing communications between users featuring a central service which formats messages into a printer-friendly format. The format of the delivered message is based on preference settings established by the recipient or an authorized agent of the recipient. The messages are delivered to a device, such as a printer. Messages can be sent to the service in any format and can include text, photographs, URLs, and/or a variety of file types. The messages are then parsed by the service and formatted for delivery to the device. | 11-13-2014 |
Patent application number | Description | Published |
20120092390 | Low Power Image Intensifier Device Comprising Black Silicon Detector Element - A detector module which may comprise a black silicon detector for detecting incident radiation and generating a visible output to a display output pixel element such as one or more OLED elements. One or more vertically interconnected unit cells, which may be in the form of a plurality of vertically stacked and bonded layers, is disclosed having a detector layer comprising one or more black silicon detector elements, an amplification layer and a display layer having a dedicated display output pixel element. The layers are vertically interconnected by means of electrically conductive area interconnects such as electrically conductive through-silicon vias. | 04-19-2012 |
20120170024 | Long Range Acquisition and Tracking SWIR Sensor System Comprising Micro-Lamellar Spectrometer - A sensor system is provided having a precision tracking sensor element and a micro-lamellar spectrometer for determining the wavelength of an electromagnetic source such as a laser designator source. Acquisition sensor elements may be provided and mounted on a rotating base element that rotates about a first axis. The precision tracking sensor elements may be mounted on a hinged or pivoting element or gimbal on the housing and provided with drive means to permit a user to selectively manually or automatically direct it toward a scene target of interest detected by the acquisition sensor elements. At least one of the imaging elements in the precision tracking sensor or acquisition sensors is stacked micro-channel plate focal plane array element. | 07-05-2012 |
20120300048 | Imaging Device and Method for Video Data Transmission Optimization - A device and method for the acquisition, processing and optimized transmission of video image data. The display output of an electronic viewing device is split by means of a beam-splitting element. A split portion of the image is detected by a detector and its output digitized. Regions of interest in the split image may be identified by eye-tracking or image saliency processing means to define salient regions in the split image. The salient regions in the split image are transmitted to a remote receiver at a higher resolution than the non-salient regions in the scene whereby video transmission bandwidth is reduced and optimized. | 11-29-2012 |
20130044317 | Active Tracking and Imaging Sensor System Comprising Illuminator Analysis Function - A sensor suite comprising a LIDAR transmitter and receiver element and a visible imager element. The transmitter operates with a plurality of selectable beam-forming optics or a tilt-tip element. A Risley or counter-rotating prism set element permits beam-steering with lower size, weight and power (SWaP). The optics for the system may be configured in a Cassegrain-type configuration in cooperation with a plurality of beam-splitting elements to permit predetermined spectrums of the received electromagnetic spectrum to be provided respectively to the LIDAR receiver and the visible imager. One or a plurality of laser illuminator analysis spectrometers are provided for the detection of incoming laser illumination from an external source which may be in the form of a micro-lamellar spectrometer element. | 02-21-2013 |
20150185079 | Hyper-Spectral and Hyper-Spatial Search, Track and Recognition Sensor - A hyper-spectral and hyper-spatial sensor system is disclosed. A micro-channel plate array imaging sensor is provided for imaging a scene of interest and cooperates with a passive imaging system which may comprise a system having a responsivity to the visible electromagnetic spectrum. Image data from the dual-sensor systems is received and processed at high processing speeds using a massively parallel image processing architecture for the detection of salient scene features in the scene. | 07-02-2015 |
Patent application number | Description | Published |
20090244079 | Optimizing the Execution of Media Processing Routines Using a List of Routine Identifiers - Methods for analyzing a list of routine identifiers to optimize processing of routines identified in the list. Some embodiments execute a set of routines in multiple passes where each pass comprises each routine in the set processing a single band of its source. The band size of the sources of the set is related to the size of a cache used during execution of the set. A band size of sources of the set is determined so that all data processed by and produced by any routine in the set can be stored to the cache while the routine processes one band of its source. Some embodiments use the list to combine two or more routines into a single routine where the list is modified accordingly. Some embodiments use the list for grouping and re-ordering routines identified in the list to send particular routines to an alternative processor for processing. | 10-01-2009 |
20120198319 | Media-Editing Application with Video Segmentation and Caching Capabilities - For a media-editing application that creates a composite media presentation, some embodiments of the invention provide a method for reducing rendering operations by dividing the composite presentation into several segments and rendering the segments in a manner that allows for these segments to move with respect to each other without losing the rendered results. The media-editing application defines portions of a media presentation as segments. When the media-editing application renders a segment of the media presentation, the application computes an identifier that uniquely identifies the segment and then uses this identifier to store and later retrieve the rendered result for the segment. The application in some embodiments computes the identifier based on a set of attributes of the segment, and stores the results of rendering the segment at a location that is uniquely identifiable in a storage structure by the identifier. | 08-02-2012 |
20120209815 | Media Clip Management - Some embodiments provide a method for editing a composite presentation in a media-editing application. The method receives a media file to import into the media-editing application from an external device. The method creates a set of media clip data structures to represent the media file. At least one of the data structures references the media file on the external device. Before the media file is imported from the external device, the method uses the media clip data structure to edit a composite presentation with the media file. After the media file is imported from the external device, automatically modifying the data structure to refer to a copy of the media file on a local device. | 08-16-2012 |
20120209889 | Data Structures for a Media-Editing Application - Some embodiments provide a method for defining a data structure for representing a media file imported into a media-editing application. The method defines a reference to an original version of a media file. The method defines references to one or more transcoded versions of the media file. Each of the transcoded versions has a different resolution. The method defines a set of metadata storing information regarding the media file. In some embodiments, the media file includes both audio and video. The method defines a video clip data structure for the media file that references the first data structure and an audio clip data structure for the media file that also references the asset data structure. The method defines a media clip data structure that contains the video clip data structure and the audio clip data structure. The media clip data structure is for editing into a composite video presentation. | 08-16-2012 |
20120210217 | Media-Editing Application with Multiple Resolution Modes - For a media-editing application, some embodiments provide a method for creating a media presentation that combines several media clips. During an editing process to define a particular media project, the method receives a first set of edits to the particular media project while the media-editing application is in a first resolution mode that uses content stored at a first resolution to generate the particular media project. The method receives a selection of a user interface tool to modify the resolution mode. The method switches to a second resolution mode that uses content stored at a second resolution to generate the particular media project without interrupting the editing process. After switching to the second resolution mode, the method receives a second set of edits to the same particular media project during the same editing process to define the particular media project. | 08-16-2012 |
20120210221 | Media-Editing Application with Live Dragging and Live Editing Capabilities - Some embodiments of the invention provide a media-editing application for creating and editing a media presentation that displays the results of edits as the edits are made to the media presentation. The media-editing application displays the movement of media clips of the media presentation as the media clips are being moved within the media-editing application to change the media presentation. Also, the media editing application in some embodiments can dynamically display the results of edits in a preview display area. That is, the media editing application has a preview generator that can generate previews of the media presentation on the fly as media clips are being dragged into and within the timeline. This allows the user of the media-editing application to see and hear the results of the operation while performing them. | 08-16-2012 |
20130124999 | REFERENCE CLIPS IN A MEDIA-EDITING APPLICATION - Some embodiments provide a media-editing application. The application defines a reference clip data structure for a media clip that represents one or more media files imported into the media-editing application. The application receives a command to add the media clip into a composite media presentation. The application defines a clip instance data structure as part of the composite media presentation. The clip instance data structure inherits properties of the reference clip data structure and subsequent modifications to the reference clip data structure affect the clip instance data structure. | 05-16-2013 |
20140331139 | MEDIA CLIP MANAGEMENT - Some embodiments provide a method for editing a composite presentation in a media-editing application. The method receives a media file to import into the media-editing application from an external device. The method creates a set of media clip data structures to represent the media file. At least one of the data structures references the media file on the external device. Before the media file is imported from the external device, the method uses the media clip data structure to edit a composite presentation with the media file. After the media file is imported from the external device, automatically modifying the data structure to refer to a copy of the media file on a local device. | 11-06-2014 |
Patent application number | Description | Published |
20100057563 | DEPLOYMENT AND DISTRIBUTION MODEL FOR IMPROVED CONTENT DELIVERY - A deployment and distribution model improves content delivery with a business incentive for placement of kiosks with one or more wireless access points in public locations so that portable media players (PMPs) can receive media content (e.g., audio, video, text, haptic content, etc.). In addition, coordination between subscribing users of PMPs, vendors who provide kiosks, and a network central controller of a content distribution system allow for prepositioning of video content at the kiosks through economically desirable low data rate communication links from the network (e.g., dial-up modem, DSL, etc.); coordinated queuing of downloads (e.g., partial downloads) between kiosk to PMP, peer-to-peer (P2P) downloading between PMPs, and uploads from PMP to kiosk; billing/crediting to correspond with such participation in the distribution; and changing priority/selection of prepositioning of content at kiosks to reflect a clientele profile. | 03-04-2010 |
20100057924 | ACCESS POINT FOR IMPROVED CONTENT DELIVERY SYSTEM - A deployment and distribution model improves content delivery with a business incentive for placement of kiosks with one or more wireless access points in public locations so that portable media players (PMPs) can receive media content (e.g., audio, video, text, haptic content, etc.). In addition, coordination between subscribing users of PMPs, vendors who provide kiosks, and a network central controller of a content distribution system allow for prepositioning of video content at the kiosks through economically desirable low data rate communication links from the network (e.g., dial-up modem, DSL, etc.); coordinated queuing of downloads (e.g., partial downloads) between kiosk to PMP, peer-to-peer (P2P) downloading between PMPs, and uploads from PMP to kiosk; billing/crediting to correspond with such participation in the distribution; and changing priority/selection of prepositioning of content at kiosks to reflect a clientele profile. | 03-04-2010 |
20100058377 | METHODS AND APPARATUS FOR AN ENHANCED MEDIA CONTEXT RATING SYSTEM - Methods, apparatus, systems and computer program products are provided for an improved media content rating system. The rating system herein disclosed is highly-granular in nature, in that, the rating system allows for ratings to be based on the number of times that portions, segments, clips of the media file are played or otherwise executed, as opposed to basing the media content rating solely on the number of times that the media file is played. In this regard, the aspects herein described may further provide for ratings of the portions, segments, clips of the media content as opposed to limiting the rating to a rating for the overall media content file. | 03-04-2010 |
20150181299 | Deployment and Distribution Model for Improved Content Delivery System - A deployment and distribution model improves content delivery with a business incentive for placement of kiosks with one or more wireless access points in public locations so that portable media players (PMPs) can receive media content (e.g., audio, video, text, haptic content, etc.). In addition, coordination between subscribing users of PMPs, vendors who provide kiosks, and a network central controller of a content distribution system allow for prepositioning of video content at the kiosks through economically desirable low data rate communication links from the network (e.g., dial-up modem, DSL, etc.); coordinated queuing of downloads (e.g., partial downloads) between kiosk to PMP, peer-to-peer (P2P) downloading between PMPs, and uploads from PMP to kiosk; billing/crediting to correspond with such participation in the distribution; and changing priority/selection of prepositioning of content at kiosks to reflect a clientele profile. | 06-25-2015 |