Freire
Adriano Freire, St. Louis Park, MN US
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20140214809 | METHOD AND SYSTEM FOR QUERY TRANSFORMATION FOR MANAGING INFORMATION FROM MULTIPLE DATASETS - A method and system for users to connect, extract, query and transform data from multiple databases, independent of their format, type, and location. The system comprises a setup portion, a meta database, and a user portion. The setup portion establishes datasets for use by the system with the user portion. The meta database stores the datasets. The user portion allows a user to input a query and processes the query to gather information from at least one data source and generate a response. | 07-31-2014 |
Ana Cristina Freire, Northampton GB
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20150125525 | DELAYED RELEASE DRUG FORMULATION - Delayed release of a drug to the colon is achieved from a delayed release formulation comprising a core and a coating for the core. The core comprises a drug and the coating comprises an inner layer and an outer layer. The outer layer comprises a mixture of a first polymeric material which is susceptible to attack by colonic bacteria, and a second polymeric material which has a pH threshold at about pH 5 or above. The inner layer comprises a third polymeric material which is soluble in intestinal fluid or gastrointestinal fluid, said third polymeric material being selected from an at least partially neutralised polycarboxylic acid and a non-ionic polymer. In embodiments in which the third polymeric material is a non-ionic polymer, the inner layer comprises at least one of a buffer agent and a base. Advantages of formulations according to the present invention include accelerated release of the drug when exposed to colonic conditions and reduction or elimination of a food and/or alcohol effect on drug release after administration. | 05-07-2015 |
Ana Cristina Teixeira De Almeida Lopes Freire, Condeixa-A-Nova PT
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20090285863 | Coating Composition Comprising Starch - The present invention provides a coating composition comprising an aqueous medium and, dispersed therein, starch and a film-forming agent which controls swelling of the starch by the aqueous medium. Formulations comprising the coating composition are also provided. The formulations may be useful in the treatment or diagnosis of colonic disease. | 11-19-2009 |
Denise Maria Guimarães Freire, Rio De Janeiro BR
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20110183400 | PROCESS FOR PRODUCTION OF LIPASES BY GENETIC MODIFICATION OF YEAST - The present invention relates to the construction of optimized synthetic lipase gene expression vectors for the high level expression of recombinant lipases in the yeast. The invention provides an enzymatic approach to the industrial processing of by-products resulting from biodiesel production. | 07-28-2011 |
Emesto Freire, Baltimore, MD US
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20140350113 | CD4-MIMETIC INHIBITORS OF HIV-1 ENTRY AND METHODS OF USE THEREOF - Described herein are small-molecule mimics of CD4, which both enter the Phe43 cavity and target Asp368 of gp120, the HIV-1 envelope protein. Also described herein are methods of using these compounds to inhibit the transmission or progression of HIV infection. These compounds exhibit antiviral potency greater than that of a known antiviral, NBD-556, with 100% breadth against clade B and C viruses. Importantly, the compounds do not activate HIV infection of CD4-negative, CCR5-positive cells, in contrast to NBD-556. | 11-27-2014 |
Emilio Freire, Madrid ES
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20100223326 | Method of Providing a Service through a User Equipment Unit in a an IP Multimedia Sub-System Telecommunications Network, Including a User Database Server, Service Policy Server and Application Server for use with Said Method - The present invention is directed to a method of providing a service through a user equipment (UE) unit in an internet protocol (IP) multimedia subsystem (IMS) telecommunications network, wherein said service is provided using an application server (AS) in said telecommunications network, said method comprising a step of performing a user authorisation query on a user database server for authorizing registration of said user equipment unit in said telecommunications network, and wherein said method further comprises a step of performing a service authorisation query on a service policy server for authorizing use of said service through said user equipment unit. The invention further relates to a user database server, a service policy server, an application server, and an interrogating call session control function (I-CSCF) entity for use in the method described above. | 09-02-2010 |
Ernesto Freire, Baltimore, MD US
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20120045367 | SYSTEM FOR CREATION OF FORMULATIONS AND GENERATION OF DENATURATION GRAPHS - A system for automatically creating a denaturation curve is disclosed. In accordance with certain embodiments, a movement system including a unit having a plurality of cannulas is used. The cannulas are in fluid communication with a fluid system, which allows the cannulas to draw in and dispense fluid. A measurement system is included which draws fluid from a well into a detector to determine a characteristic of the fluid. A controller is used to control these systems and also to create a denaturation graph from the measured characteristics. In another embodiment, a plurality of formulations may be created using the system. | 02-23-2012 |
20120045841 | SYSTEM AND METHOD FOR GENERATION OF AUTOMATED DENATURATION GRAPHS - A system and method for creating a plurality of denaturation curves is disclosed. In accordance with certain embodiments, one variable, such as salt content, pH or another parameter, is varied to create a plurality of different buffer solutions. Each is then used to create a denaturation graph. The plurality of denaturation graphs allows analysis of the effect of that variable on protein stability. | 02-23-2012 |
20120045846 | SYSTEM AND METHOD FOR pH FORMULATIONS - A system and method for creating a buffer solution having a desired pH value is disclosed. The method uses two known buffer solutions, each with predetermined pH values, and determines a mathematical relationship which defines the amount of each known buffer solution needed to create the buffer solution with the desired pH. This method can then be used to create one or more denaturation graphs, which demonstrate the stability of a protein at a given pH level. | 02-23-2012 |
20120045849 | SYSTEM AND METHOD TO MEASURE DISSOCIATION CONSTANTS - A system and method for determining the dissociation constant for a particular ligand is disclosed. In accordance with certain embodiments, the method creates a chemical denaturation curve of a protein in the absence of the ligand. A particular point is selected from this curve, such as the point at which 90% of the protein is unfolded. The molarity of chemical denaturant is determined for this selected point. A one point test is then performed for the protein with a predetermined concentration of the particular ligand. The fraction of protein which is unfolded at this point is then used to determine the dissociation constant for the ligand. This constant is used to quickly determine whether a particular ligard is well suited to be considered a potential drug candidate against that protein target. | 02-23-2012 |
20120122834 | SMALL MOLECULE CD4 MIMETICS AND USES THEREOF - The invention provides for compounds of formula I: wherein Z is absent or (CR | 05-17-2012 |
20140256778 | HIGH AFFINITY BETA LACTAMASE INHIBITORS - Inhibitors of beta lactamases and their use in treating bacterial infections are disclosed. | 09-11-2014 |
20150080451 | SERINE PROTEASE INHIBITORS - Potent low molecular weight, highly selective, competitive non-peptidic serine protease inhibitors and their use in treating serine protease-associated diseases are disclosed. | 03-19-2015 |
Jose Freire, Westfield, NJ US
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20130172303 | ROFLUMILAST COMPOSITIONS FOR THE TREATMENT OF COPD - The present invention relates to pharmaceutical compositions comprising roflumilast in combination with a corticosteroid and/or a leukotriene receptor antagonist. The invention also relates to the use of such compositions for the treatment of Chronic Obstructive Pulmonary Disorder (COPD). | 07-04-2013 |
Jose Maria Garcia-Mina Freire, Iza (navarra) ES
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20080221314 | Heteromolecular metal-humic (chelate) complexes - Heteromolecular metal-humic organic complexes of the type: | 09-11-2008 |
Juliana Freire, Salt Lake City, UT US
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20090210406 | METHOD AND SYSTEM FOR CLUSTERING IDENTIFIED FORMS - A method is provided for organizing a plurality of documents that include forms. An initial set of clusters is defined for the plurality of documents. The initial set of clusters is reclustered based on similarity values calculated in multiple feature spaces. For example, a first feature space may be associated with a content of a document while a second feature space may be associated with a content of a form associated with the document. Each cluster has an associated centroid vector in each feature space that is used to represent the cluster. The similarity between the document and each cluster is calculated in both feature spaces. Each document is assigned to the cluster whose centroid is most similar. The cluster centroids may be recalculated and the process repeated until the cluster assignments become stable. | 08-20-2009 |
20090210407 | METHOD AND SYSTEM FOR ADAPTIVE DISCOVERY OF CONTENT ON A NETWORK - A method is provided for identifying documents that include a searchable form relevant to a topic. A document is received. If the received document comprises a form is determined. A form includes a field presented to a user requesting information from the user. If the received document is determined to comprise a form, a determination is made concerning whether or not the form is a searchable form. A searchable form returns non-trivial information to a requester in response to a submission of the form. If the form is determined to be a searchable form, a determination is made concerning whether or not the form is relevant to an identified topic. If the form is determined to be relevant to the identified topic, the document is identified as a searchable form relevant to the identified topic. | 08-20-2009 |
20090310816 | ENABLING PROVENANCE MANAGEMENT FOR PRE-EXISTING APPLICATIONS - A method of providing provenance management for a pre-existing application is provided. A provenance data selection is received. The provenance data selection indicates provenance data to present to a user. The provenance data is presented to the user as a version tree comprising a plurality of connected nodes. A node selection is received. The node selection indicates a node selected from the version tree. One or more nodes from a root node of the plurality of connected nodes to the node selected from the version tree are identified. One or more action parameters associated with the identified one or more nodes are identified. An action parameter of the one or more action parameters is associated with a previous interaction with a pre-existing application. Presentation of a state of the pre-existing application associated with the node selected from the version tree is triggered. | 12-17-2009 |
20110276915 | AUTOMATED DEVELOPMENT OF DATA PROCESSING RESULTS - A method of automatically completing a workflow is provided. An indicator of a partial workflow is received in a computing device. The partial workflow includes a module configured to process data. A workflow completion is determined for the partial workflow based on the partial workflow and a plurality of workflows stored in a computer-readable medium. The workflow completion is configured to further process the data. A workflow is presented in a display operably coupled to the computing device. The workflow includes the determined workflow completion and the partial workflow. | 11-10-2011 |
20120095801 | ANALOGY BASED WORKFLOW IDENTIFICATION - A method of creating an analogous workflow is provided. A first workflow is received at a first device, the first workflow including a plurality of first modules that are connected. A second workflow is received at the first device, the second workflow including a plurality of second modules that are connected. A third workflow is received at the first device, the third workflow including a plurality of third modules that are connected. An analogy workflow is determined based on a difference between the received first workflow and the received second workflow. The determined analogy workflow is applied to the received third workflow to define a fourth workflow. A method of identifying a workflow of a plurality of workflows is provided. A query workflow includes a plurality of modules that are connected. A workflow is identified that at least partially matches the received query workflow. | 04-19-2012 |
Marcos Da Silva Freire, Manguinhos BR
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20120251570 | METHOD, KIT, PLASMID AND COMPOSITION FOR INDUCING AN IMMUNE RESPONSE TO DENGUE VIRUS, ON THE BASIS OF DNA AND CHIMERIC VIRUS VACCINES - The present invention relates to a method for inducing an immune response to the dengue virus, on the basis of DNA and 17D chimeric virus vaccines in combined or co-administered immunisation. The scope of the present invention also includes DNA vaccines against the four serotypes of the dengue virus, produced by forming, from each viral serotype of the dengue virus (DENV1-4), various recombinant plasmids that contain the gene that codes for the E protein, or that contain only the sequence that corresponds to the domain III of this protein. The invention also provides a vaccine composition consisting of (a) DNA vaccines against the four serotypes of the dengue virus; (b) chimeric viruses comprising the modified yellow fever vaccination virus 17D; and (c) a pharmaceutically acceptable carrier, all of which are covered by the scope of the invention. | 10-04-2012 |
Mário Marques Freire, Covilha PT
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20110194854 | UPSTREAM EFFICIENCY IMPROVEMENT METHOD FOR PASSIVE OPTICAL NETWORKS - A method of data transmission in a network sharing a medium using a time division multiple access scheme in which a network unit receives data packets from a subnetwork, stores the data packets in a buffer until the arrival of a time-slot and sends the data packets over the shared medium in the upstream direction during the time-slot. Each of the data packets includes a payload and a header that includes a source address and a destination address. Storing the data packets in the buffer includes: determining the paired source and the destination addresses of a received packet; determining whether a composite frame having a composite frame header including the paired source and destination addresses already exists; if negative, creating the composite frame for the paired source and destination addresses; and aggregating the payload of the packet to a composite frame payload of the composite frame. | 08-11-2011 |
Otavio R. Freire, Charlottesville, VA US
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20130339457 | METHODS AND APPARATUS FOR ANALYZING SOCIAL MEDIA FOR ENTERPRISE COMPLIANCE ISSUES - In some embodiments, a non-transitory processor-readable medium includes code that causes a processor to receive, at a compliance device, a message from a source communication device addressed to a destination communication device. The code causes the processor to analyze at a context engine, the content of the message to determine a first risk level associated with a preference of an organization. The code further causes the processor to analyze at a regulatory engine, the content of the message to determine a second risk level associated with a regulatory standard of a specific industry and to define a composite risk level based on the first risk level and the second risk level. The code further causes the processor to send a notification to an administrator if the composite risk level satisfies a criterion, and to send the message to the destination communication device irrespective of the composite risk level. | 12-19-2013 |
Paulo Sérgio Freire, Rio De Janeiro BR
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20090142241 | SYSTEM AND PROCESS FOR THE SEPARATION OF SUSPENSIONS OF SPENT CATALYSTS AND HYDROCARBONS FORMED IN A FLUID CATALYTIC CRACKING UNIT WITH MULTIPLE ASCENDING FLOW REACTION TUBES - The present invention relates to a system for the separation of suspensions of spent catalysts and hydrocarbons formed in an FCC unit with multiple ascending flow reaction tubes, comprising interconnections between each of the ascending flow reaction tubes and the separator vessel, each interconnection also comprises two sections The outside sections of the separator vessel are inclined and are connected to a single vertical section, which penetrates into the interior of the separator vessel, and which has at its lower end an open device for draining the spent catalyst from the suspensions separated in this sector. In the same vertical section, at the end of its internal part at the separator vessel, a series of two sets of cyclones are installed, the first set containing cyclones without sealing legs, and the second set containing conventional cyclones of the first stage. | 06-04-2009 |
20110104018 | DEVICE FOR COOLING AND DISTRIBUTING MIXED CHARGES ON FIXED CATALYST BEDS - This invention relates to a device for cooling and distributing mixed charges on fixed catalyst beds for use in the cooling zone of descending flow reactors which comprises a flat tray fitted with collector and distributor tubes for liquid superimposed upon and connected to another flat tray of similar design to the upper tray. The device, which is of smaller size in comparison with other commercially available devices, is extremely simple to install industrially and compact, and has as its main characteristic the efficiency with which it promotes reduction of the temperature of the reaction medium when it receives the cooling fluid within the catalytic reactor. | 05-05-2011 |
Paulo Sérgio Freire, Rio De Janeiro BR
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20110104018 | DEVICE FOR COOLING AND DISTRIBUTING MIXED CHARGES ON FIXED CATALYST BEDS - This invention relates to a device for cooling and distributing mixed charges on fixed catalyst beds for use in the cooling zone of descending flow reactors which comprises a flat tray fitted with collector and distributor tubes for liquid superimposed upon and connected to another flat tray of similar design to the upper tray. The device, which is of smaller size in comparison with other commercially available devices, is extremely simple to install industrially and compact, and has as its main characteristic the efficiency with which it promotes reduction of the temperature of the reaction medium when it receives the cooling fluid within the catalytic reactor. | 05-05-2011 |
Teresa Freire, Montevideo UY
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20100272707 | ENZYMATIC LARGE-SCALE SYNTHESIS OF MUCIN GLYCONJUGATES, AND IMMUNOGENIC APPLICATIONS THEREOF - The present invention relates to mucin glycoconjugates, and to a process of producing mucin glycoconjugates. It relates to the biological, pharmaceutical and medical applications thereof. The invention notably provides mucin glycoconjugates which do not require a protein carrier, such as KHL, to induce an immune response (anti-Tn IgG). | 10-28-2010 |