Patent application number | Description | Published |
20090281321 | EXO- AND DIASTEREO- SELECTIVE SYNTHESES OF HIMBACINE ANALOGS - This application discloses a novel process for the preparation of himbacine analogs useful as thrombin receptor antagonists. The process is based in part on the use of a base-promoted dynamic epimerization of a chiral nitro center. The chemistry taught herein can be exemplified by the following: | 11-12-2009 |
20100267947 | EXO-SELECTIVE SYNTHESIS OF HIMBACINE ANALOGS - This application discloses a novel process for the synthesis of himbacine analogs, as well as the compounds produced thereby. The synthesis proceeds by alternative routes including the cyclic ketal amide route, the chiral carbamate amide route, and the chiral carbamate ester route. The compounds produced thereby are useful as thrombin receptor antagonists. The chemistry disclosed herein is exemplified in the following synthesis sequence: | 10-21-2010 |
20110092716 | DEHYDROHALOGENATION PROCESS FOR THE PREPARATION OF INTERMEDIATES USEFUL IN PROVIDING 6,6-DIMETHYL-3-AZABICYCLO-[3.1.0]- HEXANE COMPOUNDS - The present invention provides for a process for preparing the pyrrole compounds of Formula Va and Vb. | 04-21-2011 |
20110251392 | EXO- AND DIASTEREO- SELECTIVE SYNTHESIS OF HIMBACINE ANALOGS - This application discloses a novel process for the preparation of himbacine analogs useful as thrombin receptor antagonists. The process is based in part on the use of a base-promoted dynamic epimerization of a chiral nitro center. The chemistry taught herein can be exemplified by the following: | 10-13-2011 |
20120296093 | EXO- AND DIASTEREO- SELECTIVE SYNTHESIS OF HIMBACINE ANALOGS - This application discloses a novel process for the preparation of himbacine analogs useful as thrombin receptor antagonists. The process is based in part on the use of a base-promoted dynamic epimerization of a chiral nitro center. The chemistry taught herein can be exemplified by the following: | 11-22-2012 |
Patent application number | Description | Published |
20100100000 | Minute Ventilation-Based Disordered Breathing Detection - A respiration pattern of a number of respiration cycles is detected and breath intervals (BI) and tidal volume (TVOL) measurements of each of the respiration cycles are respectively determined. An unevenly sampled instantaneous minute ventilation (iMV) signal is produced using the BI and TVOL measurements, and an evenly sampled iMV signal (resampled iMV signal) is produced using the unevenly sampled iMV signal. Disordered breathing is detected based on a comparison between a baseline threshold and the resampled iMV signal. | 04-22-2010 |
20130123874 | MONITORING RIGHT VENTRICULAR HEMODYNAMIC FUNCTION DURING PACING OPTIMIZATION - Method and systems related to monitoring right ventricular function during pacing by a cardiac rhythm management device are described. One or more pacing parameters are selected to provide cardiac resynchronization therapy. For example, the one or more pacing parameters may be selected to provide an optimal or improved therapy. The heart is paced using the selected pacing parameters. While pacing with the selected parameters, pressure is sensed via a pressure sensor disposed the pulmonary artery. The sensed pressure is analyzed to determine right ventricular function achieved during the pacing using the selected pacing parameters. A signal, such as an alert signal or control signal, is generated based on the right ventricular function achieved during the pacing. | 05-16-2013 |
20140194705 | METHOD AND SYSTEM FOR HEART FAILURE STATUS EVALUATION BASED ON A DISORDERED BREATHING INDEX - An evaluation of heart failure status is provided based on a disordered breathing index. Patient respiration is sensed and a respiration signal is generated. Disordered breathing episodes are detected based on the respiration signal. A disordered breathing index is determined based on the disordered breathing episodes. The disordered breathing index is trended and used to evaluate heart failure status. The disordered breathing index may be combined with additional information and/or may take into account patient activity, posture, sleep stage, or other patient information. | 07-10-2014 |
Patent application number | Description | Published |
20080235168 | POLICY-BASED MANAGEMENT SYSTEM WITH AUTOMATIC POLICY SELECTION AND CREATION CAPABILITIES BY USING SINGULAR VALUE DECOMPOSITION TECHNIQUE - A statistical approach implementing Singular Value Decomposition (SVD) to a policy-based management system for autonomic and on-demand computing applications. The statistical approach empowers a class of applications that require policies to handle ambiguous conditions and allow the system to “evolve” in response to changing operation and environment conditions. In the system and method providing the statistical approach, observed event-policy associated data, which is represented by an event-policy matrix, is treated as a statistical problem with the assumption that there are some underlying or implicit higher order correlations among events and policies. The SVD approach enables such correlations to be modeled, extracted and modified. From these correlations, recommended policies can be selected or created without exact match of policy conditions. With a feedback mechanism, new knowledge can be acquired as new situations occur and the corresponding policies to manage them are recorded and used to generate new event and policy correlations. Consequently, based on these new correlations, new recommended policies can be derived. | 09-25-2008 |
20080260287 | METHOD AND APPARATUS FOR ADDING SIGNATURE INFORMATION TO ELECTRONIC DOCUMENTS - In one embodiment, the present invention is a method and apparatus for adding signature information to electronic documents. One embodiment of the inventive method involves adding the signature information into a signature data field template corresponding to the electronic document, converting the signature data field template, including the added signature information, to an image file, and superimposing the image file over the electronic document to produce a signed electronic document. The inventive method substantially eliminates the potential for human error and security breaches in the signing of electronic documents. | 10-23-2008 |
20080263438 | METHOD AND APPARATUS FOR CREATING AND EDITING ELECTRONIC DOCUMENTS - In one embodiment, the present invention is a method and apparatus for creating and editing electronic documents. One embodiment of the inventive method involves generating an electronic document in a first document format type, in accordance with one or more user-specified parameters, and converting the electronic document from the first document format type into a second document format type, in accordance with a user instruction to finalize the electronic document. In one embodiment, the first document format type is a structured document format type, such as hypertext markup language or extensible markup language, while the second document format type is a secure document format type such as portable document format. | 10-23-2008 |
20100005443 | System and Methods to Create a Multi-Tenancy Software as a Service Application - A method for providing multi-tenant services includes receiving a request from a user, establishing tenancy information for the user, wherein the tenancy information is selected which corresponds to a tenant of the user from among multiple tenants, customizing the request according to the tenancy information established for the user, forwarding the request to an application that is not multi-tenant aware, receiving results of the request from the application, customizing the results according to the tenancy information established for the user and corresponding to the tenant of the user, and returning customized results to the user. | 01-07-2010 |