Patent application number | Description | Published |
20100010635 | TIBIAL TRIALING ASSEMBLY AND METHOD OF TRIALING A TIBIAL IMPLANT - A trialing assembly for use during knee replacement procedures to determine size and position of a tibial plate implant as well as the size and thickness of the articular surface prior to implantation of the implant. The trialing assembly includes a broaching plate having a tibia engaging bottom surface adapted for placement atop a tibia and an opposite top surface, the bottom and top surfaces extending between an anterior edge and a posterior edge of the broaching plate. The broaching plate includes an anterior rail and a posterior rail protruding superiorly from the top surface and extending along the anterior and posterior edges, respectively. A trialing plate is configured to removably fit atop the broaching plate between the anterior and posterior rails. The trialing plate includes an engagement member extending from a superior surface of the trialing plate and adapted to engage with an articular surface provisional. | 01-14-2010 |
20120035735 | TIBIAL PROSTHESIS - A tibial prosthesis, and, particularly, a fixed bearing tibial prosthesis has a two-pronged securement mechanism. The securement mechanism may or may not be angled. Advantageously, the securement mechanism, working alone or in cooperation with other securement features, minimizes micromotion between the tibial tray and tibial bearing component. | 02-09-2012 |
20120035737 | TIBIAL PROSTHESIS - A tibial prosthesis has a bearing component configured for an anterior-medial insertion, which advantageously avoids the extensor mechanism of the knee. A tibial tray may include a banana-shaped boss that corresponds to a notch formed in the bearing component. After the bearing component is inserted along the anterior-medial path, the boss is received within the notch by rotating the bearing component with respect to the tibial tray. This rotation seat the bearing component upon the tibial tray in the manner of a fixed-bearing prosthesis. Alternatively, the boss and notch may define angled central axes which allow straight anterior-medial insertion of the bearing component and locking engagement to the tibial tray. | 02-09-2012 |
20140052268 | TIBIAL PROSTHESIS - A tibial prosthesis, and, particularly, a fixed bearing tibial prosthesis has a two-pronged securement mechanism. The securement mechanism may or may not be angled. Advantageously, the securement mechanism, working atone or in cooperation with other securement features, minimizes micromotion between the tibial tray and tibial bearing component. | 02-20-2014 |
20140257506 | TIBIAL PROSTHESIS - A tibial prosthesis has a bearing component configured for an anterior-medial insertion, which advantageously avoids the extensor mechanism of the knee. A tibial tray may include a banana-shaped boss that corresponds to a notch formed in the bearing component. After the bearing component is inserted along the anterior-medial path, the boss is received within the notch by rotating the bearing component with respect to the tibial tray. This rotation seat the bearing component upon the tibial tray in the manner of a fixed-bearing prosthesis. Alternatively, the boss and notch may define angled central axes which allow straight anterior-medial insertion of the bearing component and locking engagement to the tibial tray. | 09-11-2014 |
Patent application number | Description | Published |
20120022355 | Integrated electrophysiology and ultrasound imaging system - An integrated electrophysiology and ultrasound imaging system includes a workstation, electrophysiology processing circuits, a compact ultrasound imaging system having a combination of an isolation circuit, an ultrasound signal generator, and a beam former within a single unit. The integrated workstation provides a single control interface and data display for the electrophysiology and ultrasound imaging subsystems. Integrating the control of electrophysiology and ultrasound imaging equipment within a single workstation reduces clinician workload. | 01-26-2012 |
20130041243 | USER INTERFACE DEVICES FOR ELECTROPHYSIOLOGY LAB DIAGNOSTIC AND THERAPEUTIC EQUIPMENT - In an electrophysiology (EP) lab, a bedside interface device allows an EP physician to directly control various diagnostic and therapeutic systems, including an electro-anatomic mapping system. The bedside interface device can include a computer with wireless communication capability as well as a touch-responsive display panel and voice recognition. The bedside interface device can also be a hand-graspable wireless remote control device that is configured to detect motions or gestures made with the remote control by the physician, allowing the physician to directly interact with the mapping system. The bedside interface device can also be a motion capture camera configured to determine motion patterns of the physician's arms, legs, trunk, face and the like, which are defined in advance to correspond to commands for the mapping system. The bedside interface device may also include voice recognition capabilities to allow a physician to directly issue verbal commands to the mapping system. | 02-14-2013 |
20130217997 | Method and apparatus for localizing an ultrasound catheter - An imaging system is provided with an ultrasound catheter and a controller coupled to the ultrasound catheter. The catheter includes a localizer sensor configured to generate positional information for the ultrasound catheter, and an imaging ultrasound sensor having a restricted field of view. The controller co-registers images from the imaging ultrasound sensor with positional information from the localizer sensor. | 08-22-2013 |
20140121659 | ELECTROGRAM-BASED ABLATION CONTROL - Methods, devices, and systems for predicting, diagnosing, and preventing adverse events during an ablation procedure are described. A method for providing ablation energy includes receiving a first signal based on biological activity of a tissue of a patient. The method further includes analyzing the first signal to yield a first data set, establishing a threshold parameter according to the first data set, and providing ablation energy for the ablation of a biological site. | 05-01-2014 |
20140364719 | Method and apparatus for localizing an ultrasound catheter - An imaging system is provided with an ultrasound catheter and a controller coupled to the ultrasound catheter. The catheter includes a localizer sensor configured to generate positional information for the ultrasound catheter, and an imaging ultrasound sensor having a restricted field of view. The controller co-registers images from the imaging ultrasound sensor with positional information from the localizer sensor. | 12-11-2014 |
20150058032 | System for sharing data within an electrophysiology lab - A system for sharing data in an electrophysiology (EP) lab including a plurality of systems comprises a data server configured to be electrically coupled with a memory device and with the plurality of systems, the memory device being coupled with a medical device. The data server is configured to receive device data stored on the memory device, to transmit the received device data to at least one of the plurality of systems, to receive device use data from at least one of the plurality of systems, and to transmit the device use data to the memory device. The systems may comprise one or more of a mapping and navigation system, an ablation system, and an EP recording system. | 02-26-2015 |
Patent application number | Description | Published |
20100189685 | Antiviral Drugs for Treatment or Prevention of Dengue Infection - Compounds, methods and pharmaceutical compositions for treating viral infections, by administering certain compounds in therapeutically effective amounts are disclosed. Methods for preparing the compounds and methods of using the compounds and pharmaceutical compositions thereof are also disclosed. In particular, the treatment and prophylaxis of viral infections such as caused by flavivirus is disclosed, i.e., including but not limited to, Dengue virus, West Nile virus, yellow fever virus, Japanese encephalitis virus, and tick-borne encephalitis virus. | 07-29-2010 |
20110158940 | SAMLL MOLECULE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DENGUE VIRUS INFECTION - Methods and pharmaceutical compositions for treating viral infections, by administering certain compounds in therapeutically effective amounts are disclosed. Methods of using the compounds and pharmaceutical compositions thereof are also disclosed. In particular, the treatment and prophylaxis of viral infections such as caused by flavivirus is disclosed, i.e., including but not limited to, Dengue virus, West Nile virus, yellow fever virus, Japanese encephalitis virus, and tick-borne encephalitis virus. | 06-30-2011 |
20120022046 | Thienopyridine Derivatives for the Treatment and Prevention of Dengue Virus Infections - Methods and pharmaceutical compositions for treating viral infections, by administering certain thienopyridine derivative compounds in therapeutically effective amounts are disclosed. Methods of using the compounds and pharmaceutical compositions thereof are also disclosed. In particular, the treatment and prophylaxis of viral infections such as caused by flavivirus is disclosed, i.e., including but not limited to, Dengue virus, West Nile virus, yellow fever virus, Japanese encephalitis virus, and tick-borne encephalitis virus. | 01-26-2012 |
20120258079 | Treatment and Prevention of Dengue Virus Infections - Methods and pharmaceutical compositions for treating viral infections, by administering certain | 10-11-2012 |
20130129677 | Thienopyridine Derivatives for the Treatment and Prevention of Dengue Virus Infections - Methods and pharmaceutical compositions for treating viral infections, by administering certain thienopyridine derivative compounds in therapeutically effective amounts are disclosed. Methods of using the compounds and pharmaceutical compositions thereof are also disclosed. In particular, the treatment of viral infections such as caused by flavivirus is disclosed, i.e., including but not limited to, Dengue virus, West Nile virus, yellow fever virus, Japanese encephalitis virus, and tick-borne encephalitis virus. | 05-23-2013 |
20130303491 | Antiviral Drugs for Treatement or Prevention of Dengue Infection - Compounds, methods and pharmaceutical compositions for treating viral infections, by administering certain compounds in therapeutically effective amounts are disclosed. Methods for preparing the compounds and methods of using the compounds and pharmaceutical compositions thereof are also disclosed. In particular, the treatment and prophylaxis of viral infections such as caused by flavivirus is disclosed, i.e., including but not limited to, Dengue virus, West Nile virus, yellow fever virus, Japanese encephalitis virus, and tick-borne encephalitis virus. | 11-14-2013 |
Patent application number | Description | Published |
20100191341 | LATERAL CONDYLE POSTERIOR INFLECTION FOR TOTAL KNEE IMPLANT - A prosthetic knee includes a femoral component and a tibial component that cooperate to promote joint stability in deep flexion of the knee. An articulating surface of the femoral component transitions from a convex curvature to a concave curvature at a femoral inflection point. An articulating surface of the tibial component transitions from a concave curvature to a convex curvature at a tibial inflection point. The femoral and tibial inflection points cooperate during flexion of the knee so that the concave curvature of the femoral component mates with the convex curvature of the tibial component. | 07-29-2010 |
20100191342 | TOTAL KNEE IMPLANT - A knee prosthesis is provided for use in knee arthroplasty. In one exemplary embodiment, the present invention provides a tibial prosthesis having a tibial baseplate with a fixed medial bearing component and a mobile lateral bearing component. In one exemplary embodiment, the lateral bearing component is secured to the lateral portion of the tibial baseplate utilizing at least one prosthetic ligament. Additionally, in one exemplary embodiment, a stop is provided to limit anterior or posterior movement of the lateral bearing component relative to the tibial baseplate. For example, the stop may be defined by cooperating shoulders formed on the lateral bearing and the tibial baseplate. | 07-29-2010 |
20110218541 | FEMORAL CUT GUIDE - The present disclosure provides a femoral cut guide for preparing a distal femur to receive a prosthetic femoral component of a knee implant. The prosthetic femoral component includes a central box. The femoral cut guide replicates the size and shape of the prosthetic femoral component, such that the femoral cut guide may serve as a trial or provisional component used to reduce and test the prepared knee joint before implanting the final prosthetic femoral component. The femoral cut guide includes a detachable box cut guide for preparing the distal femur to receive the central box of the prosthetic femoral component. | 09-08-2011 |
20120095563 | ANTERIOR CRUCIATE LIGAMENT SUBSTITUTING KNEE IMPLANTS - The present disclosure provides knee prostheses that replicate at least a portion of the function of an individual patient's anterior cruciate ligament (ACL). An exemplary knee prosthesis includes a femoral component configured to be implanted on the distal end of the patient's femur and a tibial component configured to be implanted on the proximal end of the patient's tibia. In extension, the femoral component and the tibial component may cooperate to limit anterior movement of the tibial component relative to the femoral component. In flexion, the femoral component may be free to rotate relative to the tibial component. | 04-19-2012 |
20140288564 | FEMORAL CUT GUIDE - The present disclosure provides a femoral cut guide for preparing a distal femur to receive a prosthetic femoral component of a knee implant. The prosthetic femoral component includes a central box. The femoral cut guide replicates the size and shape of the prosthetic femoral component, such that the femoral cut guide may serve as a trial or provisional component used to reduce and test the prepared knee joint before implanting the final prosthetic femoral component. The femoral cut guide includes a detachable box cut guide for preparing the distal femur to receive the central box of the prosthetic femoral component. | 09-25-2014 |
20140366678 | Vehicle Pedal Assembly Including Pedal Arm Stub with Inserts for Actuator Bar - A vehicle pedal assembly comprising a pedal including a pedal stub arm having a metal pedal arm molded into a plastic stem with inserts molded therein and an actuator bar coupled to the stem of the pedal. Fasteners extend through the actuator bar and into the inserts in the stem for securing the actuator bar to the pedal. The actuator bar is adapted to exert an active force against the pedal. In one embodiment, both the pedal arm and the actuator bar include one or more bends defined therein. The pedal arm has a length and shape dependent upon the distance and position of the floor or pedal pad relative to the pedal. The actuator bar has a length and shape dependent upon the distance and position of the pedal relative to an actuator arm. | 12-18-2014 |
20150045900 | TOTAL KNEE IMPLANT - A knee prosthesis is provided for use in knee arthroplasty. In one exemplary embodiment, the present invention provides a tibial prosthesis having a tibial baseplate with a fixed medial bearing component and a mobile lateral bearing component. In one exemplary embodiment, the lateral bearing component is secured to the lateral portion of the tibial baseplate utilizing at least one prosthetic ligament. Additionally, in one exemplary embodiment, a stop is provided to limit anterior or posterior movement of the lateral bearing component relative to the tibial baseplate. For example, the stop may be defined by cooperating shoulders formed on the lateral bearing and the tibial baseplate. | 02-12-2015 |
Patent application number | Description | Published |
20120125354 | Fire-Cured Tobacco Extract and Tobacco Products Made Therefrom - The invention provides a tobacco product including a flavorful tobacco composition in the form of an extract of a fire-cured tobacco material. Exemplary tobacco products include smoking articles, smokeless tobacco compositions, and aerosol-generating devices that do not burn tobacco. The invention also provides a process for preparing a smokeless tobacco composition, the method including: mixing a fire-cured tobacco material having a first benzo[a]pyrene concentration with water to produce an aqueous slurry; maintaining the slurry for a time and at a temperature sufficient to form a fire-cured tobacco extract, the aqueous fire-cured tobacco extract exhibiting a second benzo[a]pyrene concentration lower than the first benzo[a]pyrene concentration; separating the aqueous fire-cured tobacco extract from a residual pulp material, and mixing the aqueous fire-cured tobacco extract with a tobacco or non-tobacco plant material to form a smokeless tobacco composition. | 05-24-2012 |
20120199145 | METHOD FOR TREATING AN EXTRACTED TOBACCO PULP AND TOBACCO PRODUCTS MADE THEREFROM - The invention provides a method of producing a tobacco composition for use in a tobacco product, the method including treating a tobacco pulp with supercritical carbon dioxide. The treated tobacco pulp may exhibit a benzo[a]pyrene concentration lower than the initial benzo[a]pyrene concentration and/or a TSNA concentration lower than the initial TSNA concentration. The treated pulp can be introduced into tobacco products including smoking articles, smokeless tobacco products, and aerosol-generating devices configured for non-combustion of plant materials. | 08-09-2012 |
20120272976 | TOBACCO-DERIVED COMPONENTS AND MATERIALS - The invention provides a method of extracting and isolating certain compounds from tobacco. The resulting isolate can include more than 90% by weight of a given compound and can be used as a flavor component for tobacco material used in smoking articles and smokeless tobacco compositions. Exemplary compounds that may be present in the isolate according to the invention include, but are not limited to, solanone, neophytadiene, megastigmatrienone, β-damascenone, norsolanadione, cis-abienol, α-cembratrienediol, β-cembratrienediol, sucrose esters, and lutein. | 11-01-2012 |
20120291793 | MOLECULARLY IMPRINTED POLYMERS FOR TREATING TOBACCO MATERIAL AND FILTERING SMOKE FROM SMOKING ARTICLES - The invention provides a method of isolating certain target compounds from tobacco, tobacco materials or smoke generated by a smoking article. The method can be used to remove undesirable compounds from tobacco, tobacco materials, or tobacco smoke. The method can also be used to remove flavor compounds from tobacco or tobacco materials, which can then be used as flavor components for tobacco material used in smoking articles and smokeless tobacco compositions. | 11-22-2012 |
20130319434 | METHOD AND SYSTEM FOR MOIST TOBACCO EXTRACT ISOLATION - A system for a tobacco curing barn is capable of collecting tobacco-derived moisture from tobacco while that tobacco is cured. The system incorporates a tobacco curing barn or other type of curing enclosure, such as bulk curing barn used for the flue-curing of tobacco. The curing barn is equipped with at least one reclamation element configured to condense and collect moisture released from tobacco cured within the barn. The reclamation element is disposed in proximity with the enclosure in a manner and location providing passage of moist air released from the tobacco across a surface of the reclamation element. The system also includes at least one storage container disposed in fluid communication with the reclamation element surface and configured to store moisture and moisture-borne material collected by the reclamation element. The resulting tobacco-derived components can be blended with other tobacco materials, such as is common practice during tobacco reordering. | 12-05-2013 |
Patent application number | Description | Published |
20110275541 | USE OF MULTIPLE RECOMBINATION SITES WITH UNIQUE SPECIFICITY IN COMBINATIONAL CLONING - The present invention provides compositions and methods for recombinational cloning. The compositions include vectors having multiple recombination sites with unique specificity. The methods permit the simultaneous cloning of two or more different nucleic acid molecules. In some embodiments the molecules are fused together while in other embodiments the molecules are inserted into distinct sites in a vector. The invention also generally provides for linking or joining through recombination a number of molecules and/or compounds (e.g., chemical compounds, drugs, proteins or peptides, lipids, nucleic acids, carbohydrates, etc.) which may be the same or different. Such molecules and/or compounds or combinations of such molecules and/or compounds can also be bound through recombination to various structures or supports according to the invention. | 11-10-2011 |
20110281767 | COMPOSITIONS AND METHODS FOR MOLECULAR BIOLOGY - The present invention provides materials and methods for the utilization of the specific interaction of replication termination sequences with their binding proteins in molecular biology applications. | 11-17-2011 |
20110306098 | COMPOSITIONS AND METHODS FOR USE IN ISOLATION OF NUCLEIC ACID MOLECULES - The present invention relates generally to recombinant genetic technology. More particularly, the present invention relates to compositions and methods for use in selection and isolation of nucleic acid molecules. The invention further relates to methods for the preparation of individual nucleic acid molecules and populations of nucleic acid molecules, as well as nucleic acid molecules produced by these methods. The invention also relates to screening and/or selection methods for identifying and/or isolating nucleic acid molecules which have one or more common features (e.g., characteristics, activities, etc) and populations of nucleic acid molecules which share one or more features. | 12-15-2011 |
20120183999 | USE OF MULTIPLE RECOMBINATION SITES WITH UNIQUE SPECIFICITY IN COMBINATIONAL CLONING - The present invention provides compositions and methods for recombinational cloning. The compositions include vectors having multiple recombination sites with unique specificity. The methods permit the simultaneous cloning of two or more different nucleic acid molecules. In some embodiments the molecules are fused together while in other embodiments the molecules are inserted into distinct sites in a vector. The invention also generally provides for linking or joining through recombination a number of molecules and/or compounds (e.g., chemical compounds, drugs, proteins or peptides, lipids, nucleic acids, carbohydrates, etc.) which may be the same or different. Such molecules and/or compounds or combinations of such molecules and/or compounds can also be bound through recombination to various structures or supports according to the invention. | 07-19-2012 |
20130004996 | METHODS AND COMPOSITIONS FOR SYNTHESIS OF NUCLEIC ACID MOLECULES USING MULTIPLERECOGNITION SITES - The present invention provides compositions and methods for recombinational cloning. The compositions include vectors having multiple recombination sites and/or multiple topoisomerase recognition sites. The methods permit the simultaneous cloning of two or more different nucleic acid molecules. In some embodiments the molecules are fused together while in other embodiments the molecules are inserted into distinct sites in a vector. The invention also generally provides for linking or joining through recombination a number of molecules and/or compounds (e.g., chemical compounds, drugs, proteins or peptides, lipids, nucleic acids, carbohydrates, etc.) which may be the same or different. The invention also provides host cells comprising nucleic acid molecules of the invention or prepared according tb the methods of the invention, and also provides kits comprising the compositions, host cells and nucleic acid molecules of the invention, which may be used to synthesize nucleic acid molecules according to the methods of the invention. | 01-03-2013 |
Patent application number | Description | Published |
20090063289 | TRUSTED STATEMENT VERIFICATION FOR DATA PRIVACY - Embodiments of the present invention address deficiencies of the art in respect to privacy data management and provide a novel and non-obvious method, system and computer program product for trusted statement verification for data privacy. In one embodiment of the invention, a method for trusted statement verification for data privacy can be provided. The method can include deducing a claim from an attribute for personal data for an end user, receiving a request from a personal data consumer to vouch for an assertion based upon the attribute, comparing the assertion to the claim, and providing a voucher for the assertion to the personal data consumer on behalf of the end user if the claim supports the assertion without revealing the attribute to the personal data consumer. | 03-05-2009 |
20090171989 | Identity Data Model Broker - A method, system and computer program product for handling identity data from heterogeneous sources utilizes an Identity Data Model Broker (IDMB). The IDMB maps fields between heterogeneous data sources, served by disparate Identity Attribute Service (IdAS) context providers, to establish a normalized data format. Within an IdAS, an abstract data model, which is brokered the IDMB, is created to present a normalized view of the data from the IDMB. When a request for data is received at the IdAS, the requested data is retrieved from appropriate data sources, through respective IdAS context providers, normalized to the abstract data model, and provided to the requester by the IdAS, such that the heterogeneous data sources are shielded from the requester. | 07-02-2009 |
Patent application number | Description | Published |
20090171337 | Photodynamic-Based Cardiac Ablation Device and Method Via the Esophagus - A method and system for ablation of cardiac tissue in a living being via the esophagus is provided. The method includes the step of introducing a photodynamic substance to the cardiac tissue. A deformable, elongated body defining a proximal end and a distal end is inserted into an esophagus of the living being. The distal end of the elongated body is located proximate the cardiac tissue. A first set of electromagnetic radiation is then directed from the distal end of the elongated body towards the cardiac tissue. Reflective and opaque surfaces at the distal end of the elongated body may be used to direct the electromagnetic radiation and an expandable membrane at the distal end may be used to urge the distal end of the elongated body to a predetermined position within the esophagus. | 07-02-2009 |
20090171349 | ADJUSTABLE LENGTH FLEXIBLE POLYMER ELECTRODE CATHETER AND METHOD FOR ABLATION - An ablation catheter includes a flexible elongated shaft having a flexible electrode at its distal end. The flexible electrode includes an inner, flexible, electrically-conductive element and an outer, flexible, electrically-conductive polymer layer in electrical contact with the inner, flexible, electrically-conductive element. The catheter further includes an electrically insulative sheath surrounding at least a portion of the flexible electrode and a linear displacement mechanism capable of adjusting at least one of the electrically insulative sheath and the flexible electrode to vary a length of the flexible electrode exposed at the distal end of the shaft. Also disclosed is an adjustable length ablation electrode and methods of ablating tissue. | 07-02-2009 |
20100168550 | MULTIPLE SHELL CONSTRUCTION TO EMULATE CHAMBER CONTRACTION WITH A MAPPING SYSTEM - A system for constructing multiple shells (electronic models) indicative of the geometry and/or volume of a bodily lumen, such as a heart chamber, is configured to collect a plurality of location data points as the electrode is swept within the chamber. Each of the collected data points has an associated measured cardiac phase at which such point was acquired. The system is configured to segregate the collected electrode locations into sets based on the phase. Each set is characterized by a particular, associated phase of its constituent electrode locations. The system is configured to generate, for each set, a respective shell that will represent the chamber at the associated phase. The shells, once constructed, may be used for or in connection with a variety of diagnostic, mapping, and/or therapeutic procedures. The system is also configured to verify that the electrode is in contact with the heart tissue before using the collected data point in the shell construction (e.g., using a phase angle parameter to verify contact). | 07-01-2010 |
20110028837 | Photodynamic-based myocardial mapping device and method - A photodynamic mapping device includes a shaft with a proximal end and a distal end, at least one optical electrode at the distal end of the shaft, and at least one optical fiber positioned inside the shaft. In embodiments, the at least one optical fiber extends from the distal end of the shaft and is coupled to the at least one optical electrode provided at or about an outer surface of the device. In an embodiment, at least one optical fiber is coupled, at or about the proximal end of the shaft, to a light source coupled and an optical sensor. An analyzer can be coupled to the optical sensor. Embodiments of such devices can be configured to deliver substances, such as photodynamic therapeutic substances. | 02-03-2011 |
20110118727 | SYSTEM AND METHOD FOR ASSESSING THE FORMATION OF A LESION IN TISSUE - A method and system for assessing lesion formation in tissue is provided. The system includes an electronic control unit (ECU) configured to acquire magnitudes for a component of a complex impedance between an electrode and tissue, and the power applied to the tissue during lesion formation. The ECU is configured to calculate a value responsive to the complex impedance component and the power. The value is indicative of a predicted lesion depth, a likelihood the lesion has reached a predetermined depth, or a predicted tissue temperature. The method includes acquiring magnitudes for a component of a complex impedance between an electrode and tissue and the power applied during lesion formation. The method includes calculating a value responsive to the complex impedance component and the power, the value being indicative of a predicted lesion depth, a likelihood the lesion has reached a predetermined depth, and/or a predicted tissue temperature. | 05-19-2011 |
20110144524 | GRAPHICAL USER INTERFACE FOR REAL-TIME RF LESION DEPTH DISPLAY - A system for displaying characteristics of target tissue during an ablation procedure is provided that includes an electronic control unit (ECU) configured to receive data regarding electrical properties of the target tissue for a time period. The ECU is also configured to determine a value responsive to the data and indicative of at least one of a predicted depth of a lesion in the target tissue, a predicted temperature of the target tissue, and a likelihood of steam pop of the target tissue for the time period. The system further includes a display device operatively connected to the ECU. The display device is configured to receive the value and display a visual representation indicative of at least one of a predicted depth of a lesion in the target tissue, a predicted temperature of the target tissue, and a likelihood of steam pop of the target tissue for the time period. | 06-16-2011 |
20110144657 | SYSTEMS AND METHODS FOR DETERMINING THE LIKELIHOOD OF ENDOCARDIAL BAROTRAUMA IN TISSUE DURING ABLATION - A method and system for determining a likelihood of barotrauma occurring in tissue during the formation of a lesion therein is provided. The system includes an electronic control unit (ECU). The ECU is configured to acquire at least one value of at least one component of a complex impedance between an electrode and the tissue. The ECU is further configured to calculate an index responsive to the at least one value of the at least one complex impedance component. The index is indicative of a likelihood of barotrauma occurring in the tissue. The method comprises acquiring at least one value of at least one component of a complex impedance between an electrode and the tissue. The method further comprises calculating an index responsive to the at least one value of the at least one complex impedance component. The calculating index is indicative of a likelihood of barotrauma occurring in the tissue. | 06-16-2011 |
20120059255 | CATHETER SYSTEMS - Catheter systems include direction-sensitive, multi-polar tip electrode assemblies for electroporation-mediated therapy, electroporation-induced primary necrosis therapy and electric field-induced apoptosis therapy, including configurations for producing narrow, linear lesions as well as distributed, wide area lesions. A monitoring system for electroporation therapy includes a mechanism for delivering electrochromic dyes to a tissue site as well as a fiber optic arrangement to optically monitor the progress of the therapy as well as to confirm success post-therapy. A fiber optic temperature sensing electrode catheter includes a tip electrode having a cavity whose inner surface is impregnated or coated with thermochromic/thermotropic material that changes color with changes in temperature. An optic fiber/detector arrangement monitors the thermochromic or thermotropic materials, acquiring a light signal and generating an output signal indicative of the spectrum of the light signal. An analyzer determines an electrode temperature based on the detector output and predetermined spectrum versus temperature calibration data. | 03-08-2012 |
20130041243 | USER INTERFACE DEVICES FOR ELECTROPHYSIOLOGY LAB DIAGNOSTIC AND THERAPEUTIC EQUIPMENT - In an electrophysiology (EP) lab, a bedside interface device allows an EP physician to directly control various diagnostic and therapeutic systems, including an electro-anatomic mapping system. The bedside interface device can include a computer with wireless communication capability as well as a touch-responsive display panel and voice recognition. The bedside interface device can also be a hand-graspable wireless remote control device that is configured to detect motions or gestures made with the remote control by the physician, allowing the physician to directly interact with the mapping system. The bedside interface device can also be a motion capture camera configured to determine motion patterns of the physician's arms, legs, trunk, face and the like, which are defined in advance to correspond to commands for the mapping system. The bedside interface device may also include voice recognition capabilities to allow a physician to directly issue verbal commands to the mapping system. | 02-14-2013 |
20130338467 | Electrode catheter device with indifferent electrode for direct current tissue therapies - An electrode catheter device with indifferent electrode for direct current tissue therapies is disclosed. An example of the catheter device has a flexible tubing with at least one ablation electrode. The catheter device also may also be used with a sheath for introducing the flexible tubing inside a patient's body. An indifferent electrode on the sheath can provide a ground for a direct current (DC) pulse to deliver electrical energy and create an electrical field adjacent a tissue. Various other embodiments are also disclosed. | 12-19-2013 |
20140194867 | System and method for assessing the formation of a lesion in tissue - A method and system for assessing lesion formation in tissue is provided. The system includes an electronic control unit (ECU) configured to acquire magnitudes for a component of a complex impedance between an electrode and tissue, and the power applied to the tissue during lesion formation. The ECU is configured to calculate a value responsive to the complex impedance component and the power. The value is indicative of a predicted lesion depth, a likelihood the lesion has reached a predetermined depth, or a predicted tissue temperature. The method includes acquiring magnitudes for a component of a complex impedance between an electrode and tissue and the power applied during lesion formation. The method includes calculating a value responsive to the complex impedance component and the power, the value being indicative of a predicted lesion depth, a likelihood the lesion has reached a predetermined depth, and/or a predicted tissue temperature. | 07-10-2014 |
20140358038 | AUTOMATIC MONITORING FOR AND DETECTION OF TISSUE POP - A system that automatically detects a myocardial barotrauma (i.e., tissue pop) event so that proper post-procedure care can be given includes an electronic control unit (ECU), a computer-readable memory coupled with the ECU, and detection logic stored in the memory configured to be executed by the ECU. The detection logic is configured to receive a signal generated by an electro-acoustic transducer related to acoustic activity within the patient, monitor the signal for a pre-determined indication of a barotrauma event, and output a notification when the pre-determined indication is detected. The transducer can be integrated with an extra-body patch that includes one or more electrodes for use with a medical device navigation system. | 12-04-2014 |
Patent application number | Description | Published |
20100022655 | Therapeutic Agents For The Treatment Of Lymphoid Malignancies - Methods—for treatment and prevention of lymphoid malignancies, including, but not limited to acute lymphoblastic leukemia (ALL), chronic lymphocytic leukemia (CLL), B-cell lymphoma, Acute Myeloid leukemia (AML), and mantle cell lymphoma (MCL). The methods include administration of a therapeutically effective amount of FTY720 (2-Amino-2-[2-(4-octylphenyl)ethyl]propane 1,3-diol hydrochloride) or a derivative, pharmaceutically acceptable salt thereof, or a prodrug thereof to a subject. | 01-28-2010 |
20130123366 | Therapeutic Agents for the Treatment of Lymphoid Malignancies - Methods—for treatment and prevention of lymphoid malignancies, including, but not limited to acute lymphoblastic leukemia (ALL), chronic lymphocytic leukemia (CLL), B-cell lymphoma, Acute Myeloid leukemia (AML), and mantle cell lymphoma (MCL). The methods include administration of a therapeutically effective amount of FTY720 (2-Amino-2-[2-(4-octylphenyl)ethyl]propane 1,3-diol hydrochloride) or a derivative, pharmaceutically acceptable salt thereof, or a prodrug thereof to a subject. | 05-16-2013 |
Patent application number | Description | Published |
20100272636 | Anti-CD74 Immunoconjugates and Methods of Use - Disclosed are compositions that include anti-CD74 immunoconjugates and optionally a therapeutic and/or diagnostic agent. In preferred embodiments, the immunoconjugates comprise one or more anti-CD74 antibodies or antigen-binding fragments thereof, conjugated to a liposome or micelle. Also disclosed are methods for preparing the immunoconjugates and using the immunoconjugates in diagnostic and therapeutic procedures. In certain preferred embodiments, the therapeutic methods comprise administering to a subject with a CD74-expressing disease an anti-CD74 immunoconjugate and thereby inducing apoptosis of CD74-expressing cells. In more preferred embodiments, the CD74 immunoconjugate is capable of inducing cell death in the absence of any other therapeutic agent, although such agents may be optionally administered prior to, together with or subsequent to administration of the anti-CD74 immunoconjugate. The compositions may be part of a kit for administering the anti-CD74 immunoconjugates or compositions. | 10-28-2010 |
20110027798 | Hybridization Quantitation Method for Modified Micro-RNA and -DNA Based Oligonucleotides - Described herein is a method for the qualitative and/or quantitative determination of an analyte in a test sample which includes base pairing at least one oligonucleotide to a capture template having an overhang; and, hybridizing with a detection probe. | 02-03-2011 |
20110280913 | Methods and Compositions for Delivering Therapeutic Agents in the Treatment of B-Cell Related Disorders - Methods and compositions for treating and/or diagnosing a B-cell malignancy are described. | 11-17-2011 |
20120100068 | Anti-CD74 Immunoconjugates and Methods of Use - Disclosed are compositions that include anti-CD74 immunoconjugates and optionally a therapeutic and/or diagnostic agent. In preferred embodiments, the immunoconjugates comprise one or more anti-CD74 antibodies or antigen-binding fragments thereof, conjugated to a liposome or micelle. Also disclosed are methods for preparing the immunoconjugates and using the immunoconjugates in diagnostic and therapeutic procedures. In certain preferred embodiments, the therapeutic methods comprise administering to a subject with a CD74-expressing disease an anti-CD74 immunoconjugate and thereby inducing apoptosis of CD74-expressing cells. In more preferred embodiments, the CD74 immunoconjugate is capable of inducing cell death in the absence of any other therapeutic agent, although such agents may be optionally administered prior to, together with or subsequent to administration of the anti-CD74 immunoconjugate. The compositions may be part of a kit for administering the anti-CD74 immunoconjugates or compositions. | 04-26-2012 |
20120136063 | FTY720-DERIVED ANTICANCER AGENTS - A number of FTY720-derived compounds with antitumor activity are described. These compounds include the compounds of formula I: | 05-31-2012 |
20130142729 | Anti-CD74 Immunoconjugates and Methods of Use - Disclosed are compositions that include anti-CD74 immunoconjugates and optionally a therapeutic and/or diagnostic agent. In preferred embodiments, the immunoconjugates comprise one or more anti-CD74 antibodies or antigen-binding fragments thereof, conjugated to a liposome or micelle. Also disclosed are methods for preparing the immunoconjugates and using the immunoconjugates in diagnostic and therapeutic procedures. In certain preferred embodiments, the therapeutic methods comprise administering to a subject with a CD74-expressing disease an anti-CD74 immunoconjugate and thereby inducing apoptosis of CD74-expressing cells. In more preferred embodiments, the CD74 immunoconjugate is capable of inducing cell death in the absence of any other therapeutic agent, although such agents may be optionally administered prior to, together with or subsequent to administration of the anti-CD74 immunoconjugate. The compositions may be part of a kit for administering the anti-CD74 immunoconjugates or compositions. | 06-06-2013 |
20140005250 | Compositions and Methods for Increasing Drug Efficacy in Cancer | 01-02-2014 |
20140134265 | TEC FAMILY KINASE INHIBITOR ADJUVANT THERAPY - Described herein are methods and compositions comprising a covalent TEC family kinase inhibitor for use in adjuvant therapy, including adjuvant cancer therapy, vaccination and treatment of immune disorders and pathogenic infections. | 05-15-2014 |
20140371241 | TEC FAMILY KINASE INHIBITOR ADJUVANT THERAPY - Described herein are methods and compositions comprising a covalent TEC family kinase inhibitor for use in adjuvant therapy, including adjuvant cancer therapy, vaccination and treatment of immune disorders and pathogenic infections. | 12-18-2014 |
Patent application number | Description | Published |
20090160363 | SOLID STATE LIGHTING DEVICES AND METHODS OF MANUFACTURING THE SAME - Lighting devices comprising first, second and third strings of solid state lighting devices. One aspect further comprises means for supplying first fixed current through the first string, means for supplying second fixed current through the second string, and means for supplying current through the third string. In a second aspect, the first and second strings emit light within a specific area on a 1931 CIE Chromaticity Diagram, and the third string emits light of dominant wavelength 600-640 nm. A third aspect further comprises a power line and a power supply configured to supply a first and second fixed currents through the first and second strings, respectively, and supply a current to the third string. A method of making a lighting device, comprising measuring color output, adjusting current to first, second and/or third strings, and permanently setting currents to the first and second strings. | 06-25-2009 |
20140368117 | SOLID STATE LIGHTING DEVICES AND METHODS OF MANUFACTURING THE SAME - Lighting devices comprising first, second and third strings of solid state lighting devices. One aspect further comprises means for supplying first fixed current through the first string, means for supplying second fixed current through the second string, and means for supplying current through the third string. In a second aspect, the first and second strings emit light within a specific area on a 1931 CIE Chromaticity Diagram, and the third string emits light of dominant wavelength 600-640 nm. A third aspect further comprises a power line and a power supply configured to supply a first and second fixed currents through the first and second strings, respectively, and supply a current to the third string. A method of making a lighting device, comprising measuring color output, adjusting current to first, second and/or third strings, and permanently setting currents to the first and second strings. | 12-18-2014 |
Patent application number | Description | Published |
20090292443 | APPROACH FOR REDUCING OVERHEATING OF DIRECT INJECTION FUEL INJECTORS - A method of controlling fuel supplied to an engine is provided. The engine includes at least one cylinder having a port injection fuel injector being supplied with fuel from at least one of a first fuel storage tank and a second fuel storage tank and a direct injection fuel injector being selectively supplied with fuel from one of the first fuel storage tank and the second fuel storage tank. The method includes at a first condition, supplying at least some of a second type of fuel from the second fuel storage tank to the direct injection fuel injector and supplying at least some of a first type of fuel from the first fuel storage tank to the port injection fuel injector, and at a second condition, supplying at least some of the first type of fuel from the first fuel storage tank to the direct injection fuel injector. | 11-26-2009 |
20110106403 | APPROACH FOR REDUCING OVERHEATING OF DIRECT INJECTION FUEL INJECTORS - A method of controlling fuel supplied to an engine is provided. In one example, a cylinder includes port and direct fuel injection. The method includes supplying a second fuel type from a second tank to the direct injector and supplying a first fuel type from a first tank to the port injector; and responsive to mis-fueling, supplying the first fuel type from the first tank to the direct injector. In response to receiving an indication of a mis-fuel, the direct fuel injector may be supplied with the second type of fuel from the second fuel storage tank. By supplying at least some fuel to the direct injector from a different source, fuel may be supplied to the DI fuel injector at various conditions to cool the DI fuel injector. In this way, overheating of the DI fuel injector may be reduced. | 05-05-2011 |
20140041380 | MULTI-STAGED WASTEGATE - Embodiments for controlling boost pressure are provided. In one example, a method of controlling a turbocharger of an engine via a multi-staged wastegate comprises during a first condition, actuating a first stage of the wastegate based on boost pressure generated by the turbocharger, and actuating a second stage of the wastegate based on a temperature of a catalyst downstream of the turbocharger. In this way, catalyst heating and boost control may be provided by a common wastegate. | 02-13-2014 |
20140060006 | METHOD AND SYSTEM FOR OPERATING AN ENGINE TURBOCHARGER - A system and method for operating an engine turbocharger is described. In one example, the turbocharger is rotated in different directions in response to operating conditions. The system and method may reduce engine emissions. | 03-06-2014 |
20140067227 | METHOD AND SYSTEM FOR IMPROVING STARTING OF A TURBOCHARGED ENGINE - A system and method for improving engine emissions is described. In one example, engine emissions may be improved via increasing rotational resistance of a turbocharger while a temperature of an exhaust after treatment device is less than a threshold temperature. The system and method may reduce an amount of time for the after treatment device to reach an operating temperature. | 03-06-2014 |
20140338617 | CAM PHASER SYSTEM AND METHOD - An engine system is provided. The engine system includes a drive component coupled to a first end of a camshaft and mechanically coupled to a crankshaft and a cam phaser coupled to a second end of the camshaft and mechanically coupled to and spaced away from the drive component, the cam phaser configured to alter the timing of the camshaft. | 11-20-2014 |
Patent application number | Description | Published |
20090276378 | System and Method for Identifying Document Structure and Associated Metainformation and Facilitating Appropriate Processing - A system and method for processing documents by utilizing the textual content and layout of the documents, including visual indicators, to more efficiently and reliably process the documents across various document types. The system and method identifies visually distinguishable elements within the document, such as section and sub-section boundary indicators, to mark, divide and label the boundaries and content type such that the sections are more clearly identifiable and easily processed. The system and method uses known elements, including section heading types, keywords, section type classifiers, sub-section heading constructs, stop words, and the like to adaptively identify and process a broad range of document types. The system and method continually refines and updates these known elements and allows users to discover and define new elements for further refinement and updating. | 11-05-2009 |
20100104087 | System and Method for Automatically Generating Adaptive Interaction Logs from Customer Interaction Text - A system and method for providing an adaptive Interaction Logging functionality to help agents reduce the time spent documenting contact center interactions. In a preferred embodiment the system uses a pipeline comprising audio capture of a telephone conversation, automatic speech transcription, text normalization, transcript generation and candidate call log generation based on Real-time and Global Models. The contact center agent edits the candidate call log to create the final call log. The models are updated based on analysis of user feedback in the form of the editing of the candidate call log done by the contact center agents or supervisors. The pipeline yields a candidate call log which the agents can edit in less time than it would take them to generate a call log manually. | 04-29-2010 |
20100274618 | System and Method for Real Time Support for Agents in Contact Center Environments - A real-time method and system are described for automatically extracting text from the customer-agent interaction at a contact center, analyzing the extracted text to automatically identify one or more customer issues, and performing processing by contact-center agent buddies (CABs) to generate at least one response to the customer issues. | 10-28-2010 |
Patent application number | Description | Published |
20130083984 | METHOD AND SYSTEM OF AUTOMATIC DETERMINATION OF GEOMETRIC ELEMENTS CHARACTERIZING A BONE DEFORMATION FROM 3D IMAGE - The invention relates to a method for automatically determining, on a bone comprising a head portion contiguous to a neck portion, parameters for characterizing a bump deformation on the head-neck junction of the bone from acquired 3D medical image, the method comprising the following steps: i) constructing a 3D surface model of the bone; ii) fitting a sphere on the spherical portion of the head of the bone; iii) determining a neck axis characterizing the neck portion of the bone; iv) determining from the fitted sphere and the neck axis, a clock face referential on the head of the bone rotating around the neck axis; v) determining a 3D curve on the 3D surface model characterizing the head-neck junction of the bone; vi) determining, from the 3D curve, the summit of the bump deformation of the head-neck junction of the bone; vii) determining, from said summit of the bump deformation, first and a second parameters (α3D, iMax) characterizing the maximum bump deformation of the head-neck junction of the bone. | 04-04-2013 |
20130085723 | METHOD FOR DETERMINING ARTICULAR BONE DEFORMITY RESECTION USING MOTION PATTERNS - The invention relates to a method for real-time determination an optimal corrected surface of a first bone and/or a second bone forming together an articulation, the first and/or second bones presenting an overgrowth deformation, said corrected surface providing a greater range of motion of the articulation, the method comprising the following steps: i) constructing from acquired images of the articulation 3D voxel models of the first bone and the second bone; ii) for each of first and second bone voxel models, constructing a coordinate system defmed by a center and three axes; iii) applying a motion pattern on the coordinate system of the second bone with respect to the coordinate system of the first bone, a motion pattern being a set of contiguous positions of the first or second bone coordinate systems with respect to the other bone coordinate system, the contiguous positions defining a movement of one bone with respect to the other, wherein said motion pattern is initially loaded from a data base of pre-defined motion patterns; iv) determining a resection volume from said motion pattern as being the union of interpenetration volumes of the first or second bone voxel model with the other bone voxel model for each position of the motion pattern; v) determining the optimal corrected surface by virtually removing said resection volume from the first and/or the second bone voxel model. | 04-04-2013 |
20130089253 | METHOD FOR DETERMINING BONE RESECTION ON A DEFORMED BONE SURFACE FROM FEW PARAMETERS - The invention relates to a method for non-invasive reproducible determination of a corrected surface on a 3D bone surface model constructed from 3D medical image of a bone having a deformation consisting in a bump overgrowth at the head-neck junction; wherein said corrected surface comprises: i) a 3D spherical corrected surface patch on the head portion of said 3D bone surface model, and ii) a 3D smooth transition corrected surface patch on the neck portion of said 3D bone surface model, contiguous to said 3D spherical corrected surface patch; Said corrected surface patches are defined by a set of parameters comprising: iii) at least one first parameter (a*) representing a spherical extent value of said 3D spherical corrected surface patch, iv) and a set of at least one second parameter, said set determining the 3D correction boundary of said corrected surface patches, such that said corrected surface patches are continuous with said 3D bone surface model along said boundary. | 04-11-2013 |
20150049928 | METHOD AND SYSTEM OF AUTOMATIC DETERMINATION OF GEOMETRIC ELEMENTS CHARACTERIZING A BONE DEFORMATION FROM 3D IMAGE - The invention relates to a method for automatically determining, on a bone comprising a head portion contiguous to a neck portion, parameters for characterizing a bump deformation on the head-neck junction of the bone from acquired 3D medical image, the method comprising the following steps: i) constructing a 3D surface model of the bone; ii) fitting a sphere on the spherical portion of the head of the bone; iii) determining a neck axis characterizing the neck portion of the bone; iv) determining from the fitted sphere and the neck axis, a clock face referential on the head of the bone rotating around the neck axis; v) determining a 3D curve on the 3D surface model characterizing the head-neck junction of the bone; vi) determining, from the 3D curve, the summit of the bump deformation of the head-neck junction of the bone; vii) determining, from said summit of the bump deformation, first and a second parameters (α3D, iMax) characterizing the maximum bump deformation of the head-neck junction of the bone. | 02-19-2015 |
Patent application number | Description | Published |
20100082011 | FLUID DETECTION IN AN ENTERAL FEEDING SET - Detection of fluid conditions in an administration set. A light source is positioned to transmit an infrared light through administration set tubing and any fluid therein. A light sensor senses the infrared light transmitted through the tubing and generates an output signal. A frequency of the output signal is a function of an intensity of the light transmitted through the tubing. A processor receives and determines the frequency of the output signal, and compares the determined frequency to threshold frequency values to determine whether fluid is in the tubing. The processor also monitors the generated output signal to determine if the frequency of the output signal changes over time, and determines whether fluid is flowing in the tubing as a function of the determined change in frequency. | 04-01-2010 |
20120065469 | CATHETER WITH IMAGING ASSEMBLY - A catheter with an imaging assembly is disclosed. The catheter is used with a console for viewing and/or storing images obtained from the catheter. The catheter may be a feeding tube assembly. The imaging assembly on the feeding tube assembly allows a user to confirm placement of the feeding tube assembly in the patient's alimentary canal. | 03-15-2012 |
20120172665 | Assembly with Imaging Electronics - A catheter with an imaging assembly is disclosed. The catheter is used with a console for viewing and/or storing images obtained from the catheter. The catheter may be a feeding tube assembly. The imaging assembly on the feeding tube assembly allows a user to confirm placement of the feeding tube assembly in the patient's alimentary canal. | 07-05-2012 |
20140024893 | Feeding Tube System with Imaging Assembly and Console - A catheter with an imaging assembly is disclosed. The catheter is used with a console for viewing and/or storing images obtained from the catheter. The catheter may be a feeding tube assembly. The imaging assembly on the feeding tube assembly allows a user to confirm placement of the feeding tube assembly in the patient's alimentary canal. | 01-23-2014 |
20140094652 | Feeding Tube System with Imaging Assembly and Console Connector - A catheter with an imaging assembly is disclosed. The catheter is used with a console for viewing and/or storing images obtained from the catheter. The catheter may be a feeding tube assembly. The imaging assembly on the feeding tube assembly allows a user to confirm placement of the feeding tube assembly in the patient's alimentary canal. | 04-03-2014 |
20140296775 | FLUID DETECTION IN AN ENTERAL FEEDING SET - Detection of fluid conditions in an administration set. A light source is positioned to transmit an infrared light through administration set tubing and any fluid therein. A light sensor senses the infrared light transmitted through the tubing and generates an output signal. A frequency of the output signal is a function of an intensity of the light transmitted through the tubing. A processor receives and determines the frequency of the output signal, and compares the determined frequency to threshold frequency values to determine whether fluid is in the tubing. The processor also monitors the generated output signal to determine if the frequency of the output signal changes over time, and determines whether fluid is flowing in the tubing as a function of the determined change in frequency. | 10-02-2014 |