Patent application number | Description | Published |
20090076142 | USE OF THE IRRITATING PRINCIPAL OLEOCANTHAL IN OLIVE OIL, AS WELL AS STRUCTURALLY AND FUNCTIONALLY SIMILAR COMPOUNDS - The invention provides methods of synthesizing the purified enantiomers of oleocanthal. The invention further provides methods of using oleocanthals in various formulations including, food additives; pharmaceuticals; cosmetics; animal repellants; and discovery tools for mammalian irritation receptor genes, gene products, alleles, splice variants, alternate transcripts and the like. | 03-19-2009 |
20090163563 | Phorboxazole Compounds and Methods of Their Preparation - Novel macrolactone compounds, their methods of preparation, pharmaceutical compositions containing these compounds, and methods for their pharmaceutical use are disclosed. In certain embodiments, the macrolactone compounds may be useful, inter alia, for treating various cancers, inducing apoptosis in malignant cells, or inhibiting cancer cell division. | 06-25-2009 |
20090187031 | Synthetic techniques and intermediates for polyhydroxy dienyl lactones and mimics thereof - Synthetic methods and intermediates useful in the preparation of lactone containing compounds such as discodermolide and compounds which mimic the chemical or biological activity of discodermolide are provided. | 07-23-2009 |
20090306014 | C-10 CARBAMATES OF TAXANES - Provided herein are C-10 taxane carbamates and pharmaceutically acceptable derivatives thereof. In certain embodiments, provided herein are compounds, compositions and methods for treating cancer and taupathy. | 12-10-2009 |
20110020424 | USE OF THE IRRITATING PRINCIPAL OLEOCANTHAL IN OLIVE OIL, AS WELL AS STRUCTURALLY AND FUNCTIONALLY SIMILAR COMPOUNDS - The invention provides oleocanthal analogs and methods of using oleocanthals in various formulations including, food additives; pharmaceuticals; cosmetics; animal repellants; and discovery tools for mammalian irritation receptor genes, gene products, alleles, splice variants, alternate transcripts and the like. | 01-27-2011 |
20110172220 | DISCODERMOLIDE ANALOGUES AND METHODS OF THEIR USE - 6- and 7-substituted coumarin and related 6- and 7-substituted 1H-quinolin-2-one compounds, pharmaceutical compositions containing these compounds, and methods for their pharmaceutical use are disclosed. In certain embodiments, the 7-substituted coumarin and related 7-substituted 1H-quinolin-2-one compounds mimic or exceed the high level of pharmacological activity of discodermolide. In other embodiments, their preparation involves more readily available materials, higher yield processes and/or simpler synthetic sequences. In yet other embodiments, the compounds of the invention represent structurally simpler, therapeutically active analogues of discodermolide than heretofore known and may be useful as microtubule stabilizers and, inter alia, for treating and/or preventing cancer and other diseases, disorders, and/or conditions mediated by the stabilization of microtubules. | 07-14-2011 |
20120122834 | SMALL MOLECULE CD4 MIMETICS AND USES THEREOF - The invention provides for compounds of formula I: wherein Z is absent or (CR | 05-17-2012 |
20120329877 | Cycloalkyl-dione Derivatives And Methods Of Their Use - The present invention is directed to compounds of formula I: | 12-27-2012 |
20130029983 | AMINOTHIENOPYRIDAZINE INHIBITORS OF TAU ASSEMBLY - The present invention is directed to methods of inhibiting a tauopathy in a patient by administration of a compound of formula I: | 01-31-2013 |
20130030027 | HEMI-PHORBOXAZOLE A DERIVATIVES AND METHODS OF THEIR USE - The present invention is directed to hemi phorboxazole A: and its stereoisomers, as well as derivatives of hemi phorboxazole A of formula I: wherein ring A is aryl or a 5- or 6-membered heteroaryl optionally substituted with one or more of halogen, —OH, or —C | 01-31-2013 |
20130165489 | Small Molecule Modulators of HIV-1 Capsid Stability and Methods Thereof - The present invention includes a method of inhibiting, suppressing or preventing a viral infection in a subject, comprising administering to the subject a pharmaceutical composition comprising one or more of the compounds useful within the invention. | 06-27-2013 |
20140350113 | CD4-MIMETIC INHIBITORS OF HIV-1 ENTRY AND METHODS OF USE THEREOF - Described herein are small-molecule mimics of CD4, which both enter the Phe43 cavity and target Asp368 of gp120, the HIV-1 envelope protein. Also described herein are methods of using these compounds to inhibit the transmission or progression of HIV infection. These compounds exhibit antiviral potency greater than that of a known antiviral, NBD-556, with 100% breadth against clade B and C viruses. Importantly, the compounds do not activate HIV infection of CD4-negative, CCR5-positive cells, in contrast to NBD-556. | 11-27-2014 |
20150152216 | SILICON-BASED CROSS COUPLING AGENTS AND METHODS OF THEIR USE - Compositions and methods using silicon-based cross-coupling agents in the formation of carbon-carbon and carbon-nitrogen bonds are described. | 06-04-2015 |
20150344462 | IRCINIASTATIN ANALOGUES - The present invention is directed to irciniastatin analogues. Uses of these analogues also described. | 12-03-2015 |
20150376579 | Methods Of Stapling And Unstapling Peptides And Proteins - The present disclosure pertains to the field peptide stapling and/or macrocyclization, where a structural motif is used to improve the properties of amino acid sequences (e.g. protease resistance, cellular penetration, biological activity). Also within the scope of the disclosure are methods for unstapling the S,S-tetrazine-containing amino acid sequence. The disclosure is also directed to methods for the reductive removal of thiocyanates from an amino acid sequence with cysteine to recycle back to the native amino acid sequence. | 12-31-2015 |
Patent application number | Description | Published |
20090039788 | LIGHT UNIT WITH INTERNAL BACK-UP POWER SUPPLY, COMMUNICATIONS AND DISPLAY - A light unit that includes an internal power supply that may be used in the event of an external power failure to provide power to the light unit. In one aspect, the present disclosure provides a lighting apparatus, comprising (a) a power input configured to receive external power from an external power source; (b) a solid state light element that is interconnected to the power input; and (c) a back-up power source that is interconnected to the solid state light element and the power input and that provides power to the solid state light element when the light element is not provided with power from the power input. | 02-12-2009 |
20100135000 | LIGHT UNIT WITH INTERNAL POWER FAILURE DETECTION - A light unit that includes an internal power supply that may be used in the event of an external power failure to provide power to the light unit. In one aspect, the present disclosure provides a lighting apparatus, comprising (a) a power input configured to receive external power from an external power source; (b) a solid state light element that is interconnected to the power input; (c) a detection circuit interconnected to the power input and that, when power is not provided to the power input, measures input impedance at the power input and determines if there is a lack of external power; and (d) a back-up power source that is interconnected to the solid state light element and the power input and that provides power to the solid state light element when the light element is; not provided with power from the power input. | 06-03-2010 |
20100315813 | SOLID STATE LIGHT UNIT AND HEAT SINK, AND METHOD FOR THERMAL MANAGEMENT OF A SOLID STATE LIGHT UNIT - A lamp assembly manages thermal energy output from solid state lighting elements. An aspect of the present disclosure provides a lamp assembly that achieves enhanced cooling of light elements within the assembly. Enhanced cooling is achieved, in this aspect, by providing a lamp assembly including a heat sink having a plurality of thermo bosses protruding therefrom on a first side, and a plurality of heat sink fins on a second side. A printed circuit board is secured to the first side of the heat sink, and has a plurality of through holes that correspond to the size and locations of the thermo bosses, such that when the printed circuit board is secured to the heat sink, the thermo bosses extend into the through holes. | 12-16-2010 |
Patent application number | Description | Published |
20090122264 | Methods and Apparatuses for Enhancing Peripheral Vision - Methods and apparatuses are disclosed for improving peripheral vision by positioning the peripheral image points at a pre-determined and precise position relative to the retina to achieve optimal performance according to one or more pre-selected criteria parameters for optimal peripheral vision performance. | 05-14-2009 |
20090161065 | Methods and Apparatuses for Altering Relative Curvature of Field and Positions of Peripheral, Off-Axis Focal Positions - A method and apparatus are disclosed for controlling optical aberrations to alter relative curvature of field by providing ocular apparatuses, systems and methods comprising a predetermined corrective factor to produce at least one substantially corrective stimulus for repositioning peripheral, off-axis, focal points relative to the central, on-axis or axial focal point while maintaining the positioning of the central, on-axis or axial focal point on the retina. The invention will be used to provide continuous, useful clear visual images while simultaneously retarding or abating the progression of myopia or hypermetropia. | 06-25-2009 |
20100110371 | Method and Apparatus for Controlling Peripheral Image Position for Reducing Progression of Myopia - A method and apparatus are disclosed for controlling optical aberrations to alter relative curvature of field by providing optical devices and methods comprising the repositioning of peripheral off-axis focal points relative to the retina to produce stimulus for influencing the progression of refractive error while simultaneously controlling the position of the central focal point near to the retina to provide clear central vision and simultaneously providing zones of controlled peripheral defocus and other optical aberrations to improve peripheral vision for select directions of gaze. | 05-06-2010 |
20120320333 | CONTACT LENSES FOR MYOPIC EYES AND METHODS OF TREATING MYOPIA - A contact lens and a method for treating an eye with myopia is described. The contact lens includes an inner optic zone and an outer optic zone. The outer optic zone includes at least a portion with a first power, selected to correct distance vision. The inner optic zone has a relatively more positive power (an add power). In some embodiments the add power is substantially constant across the inner optic zone. In other embodiments the add power is variable across the inner optic zone. While in some embodiments the inner optic zone has a power designed to substantially eliminate lag of accommodation in the eye with myopia, in other embodiments, the add power may be higher. | 12-20-2012 |
20120320334 | CORNEAL REMODELLING CONTACT LENSES AND METHODS OF TREATING REFRACTIVE ERROR USING CORNEAL REMODELLING - Contact lenses are described with a corneal remodelling effect. This corneal remodelling effect is one or both of broad-area corneal remodelling and localised remodelling. The contact lenses may also have a refractive power. The refractive power may vary across the lens and for myopia may have increased power centrally. The increased power may be provided over a lens area that has increased thickness due to localised remodelling. | 12-20-2012 |
20130010255 | Means for Controlling the Progression of Myopia - A contact lens ( | 01-10-2013 |
20130182216 | TREATING OCULAR REFRACTIVE ERROR - A lens for an eye that includes a zone with a first power profile for images received by the retina on the fovea, a zone with a second power profile for images received by the peripheral retina on the nasal side and a zone with a third power profile for images received by the peripheral retina on the temporal side. The first power profile is selected to provide clear or acceptable vision and the second and third power profiles are selected to affect the peripheral image position. | 07-18-2013 |
20140132914 | MEANS FOR CONTROLLING THE PROGRESSION OF MYOPIA - A contact lens for use in controlling or retarding the progression of myopia in an eye has a central optical zone approximating the normal diameter of the pupil of the eye that gives clear central vision at distance for the wearer. An annular peripheral optical zone that is substantially outside the diameter of the pupil is formed around the central optical zone with greater refractive power than that of the central zone so that oblique rays entering the eye through the peripheral optical zone will be brought to focus at a focal plane that is substantially on or anterior to the peripheral region of the retina. Preferably, the rear surface of the lens is shaped to conform to the cornea of the eye and the front surface of the lens is shaped to provide—in conjunction with the rear surface—the desired optical properties of the central and peripheral optical zones. The front surface is also preferably contoured to form a smooth transition between the junction of the central optical zone and the peripheral optical zone, with or without designed optical properties such as progressive power. | 05-15-2014 |
20150085247 | CONTACT LENSES FOR MYOPIC EYES AND METHODS OF TREATING MYOPIA - A contact lens and a method for treating an eye with myopia is described. The contact lens includes an inner optic zone and an outer optic zone. The outer optic zone includes at least a portion with a first power, selected to correct distance vision. The inner optic zone has a relatively more positive power (an add power). In some embodiments the add power is substantially constant across the inner optic zone. In other embodiments the add power is variable across the inner optic zone. While in some embodiments the inner optic zone has a power designed to substantially eliminate lag of accommodation in the eye with myopia, in other embodiments, the add power may be higher. | 03-26-2015 |
20150234203 | CORNEAL REMODELLING CONTACT LENSES AND METHODS OF TREATING REFRACTIVE ERROR USING CORNEAL REMODELLING - Contact lenses are described with a corneal remodelling effect. This corneal remodelling effect is one or both of broad-area corneal remodelling and localised remodelling. The contact lenses may also have a refractive power. The refractive power may vary across the lens and for myopia may have increased power centrally. The increased power may be provided over a lens area that has increased thickness due to localised remodelling. | 08-20-2015 |
20150331255 | Lens for Myopic Eye - An ophthalmic lens element includes an upper distance viewing zone and a lower near viewing zone. The upper distance viewing zone includes a central region with a first refractive power for clear distance vision and peripheral regions that are relatively positive in power compared to the first refractive power. The lower near viewing zone has a central region that is relatively positive in power compared to the first refractive power to account for accommodative lag. The powers of the peripheral regions of the lower near viewing zone are one of: i) equal to the power of the central region of the lower near viewing zone, ii) relatively positive in comparison to the power of the central region of the lower near viewing zone. | 11-19-2015 |
Patent application number | Description | Published |
20110251908 | PERSONAL INTERFACE DEVICE AND METHOD - A personal device is provided. The personal device includes an identification verification system that receives first identification data from a physical identification device, such as by inserting a driver's license into a card reader that is adapted to receive a driver's license. Second identification data such as a PIN number is also received. Payment authorization data or other suitable data is generated if the driver's license corresponds to the PIN. A payment selection system or other suitable system receives the payment authorization data and displays one or more payment accounts for selection by a user. Where a payment selection system is used, the payment selection system transmits payment account data to a point-of-sale system. | 10-13-2011 |
20130173406 | PERSONAL INTERFACE DEVICE AND METHOD - A personal device is provided. The personal device includes an identification verification system that receives first identification data from a physical identification device, such as by inserting a driver's license into a card reader that is adapted to receive a driver's license. Second identification data such as a PIN number is also received. Payment authorization data or other suitable data is generated if the driver's license corresponds to the PIN. A payment selection system or other suitable system receives the payment authorization data and displays one or more payment accounts for selection by a user. Where a payment selection system is used, the payment selection system transmits payment account data to a point-of-sale system. | 07-04-2013 |
20150072763 | GAME LIVE AUCTION SYSTEM AND METHOD OF OPERATION - A method for conducting a raffle comprising reading an item identifier from an identification tag affixed to an item at an equipment management system, prior to an event related to the item. The raffle notification data is then transmitted to users after the event has occurred. A plurality of raffle ticket purchase requests are then received from the plurality of devices and are processed. The raffle tickets are then delivered to the plurality of devices, such as in electronic form. One of the raffle tickets is then selected, and winning notification data is transmitted to the associated device. The winner can authenticate the winning item by reading the identification tag affixed to the item after the event at the equipment management system. | 03-12-2015 |
20150127434 | EVENT DISPLAY SYSTEM AND METHOD - A system comprising an information control system configured to receive item data and event identification data associated with the item data, to format the item data and the event identification data, and to provide the item data and the event identification data to an event display. A display control system configured to receive auction data for an item associated with the item data and to initiate an auction after a start of an event associated with the event identification data by generating a notification on the event display. An item registration system configured to read unique item identification data from the item and to store the unique item identification data with time of event data. | 05-07-2015 |
20150199879 | GAME LIVE AUCTION SYSTEM AND METHOD OF OPERATION - A method for conducting a raffle comprising reading an item identifier from an identification tag affixed to an item at an equipment management system, prior to an event related to the item. The raffle notification data is then transmitted to users after the event has occurred. A plurality of raffle ticket purchase requests are then received from the plurality of devices and are processed. The raffle tickets are then delivered to the plurality of devices, such as in electronic form. One of the raffle tickets is then selected, and winning notification data is transmitted to the associated device. The winner can authenticate the winning item by reading the identification tag affixed to the item after the event at the equipment management system. | 07-16-2015 |
20150347998 | PERSONAL INTERFACE DEVICE AND METHOD - A personal device is provided. The personal device includes an identification verification system that receives first identification data from a physical identification device, such as by inserting a driver's license into a card reader that is adapted to receive a driver's license. Second identification data such as a PIN number is also received. Payment authorization data or other suitable data is generated if the driver's license corresponds to the PIN. A payment selection system or other suitable system receives the payment authorization data and displays one or more payment accounts for selection by a user. Where a payment selection system is used, the payment selection system transmits payment account data to a point-of-sale system. | 12-03-2015 |
Patent application number | Description | Published |
20090189591 | Power Supply Insensitive PTAT Voltage Generator - In temperature sensing circuitry PTAT (Proportional to Absolute Temperature) Voltage References are typically used. By adding a feedback circuit and a source follower into the classic design, the circuit can guarantee that the current is mirrored identically regardless of the value of power supply voltage. This added circuitry is easy to implement and is low in both power and area. The essence of this invention is that the PTAT circuit allows a large range of operation including low voltage (1 Volt) and more accurate temperature readings. | 07-30-2009 |
20100001804 | SYSTEM TO IMPROVE A VOLTAGE-CONTROLLED OSCILLATOR AND ASSOCIATED METHODS - A system to improve a voltage-controlled oscillator may include a voltage-controlled oscillator. The system may also include a switch to control a first voltage passing through the voltage-controlled oscillator based upon a digital tune bit used to control the voltage-controlled oscillator's gain. | 01-07-2010 |
20110316593 | Phase Locked Loop with Startup Oscillator and Primary Oscillator - A voltage controlled oscillator (VCO) for a phase locked loop (PLL) includes a startup oscillator, the startup oscillator comprising a first plurality of inverters; a primary oscillator, the primary oscillator comprising a second plurality of inverters, wherein a number of the second plurality of inverters is fewer than the number of the first plurality of inverters; and a control module connected to the startup oscillator and the primary oscillator. A method of operating a voltage controlled oscillator (VCO) in a phase locked loop (PLL), the VCO comprising a startup oscillator and a primary oscillator includes sending an enable signal to the startup oscillator; waiting a predetermined number of startup oscillator clock cycles; and when the predetermined number of startup oscillator clock cycles has elapsed, sending a disable signal to the startup oscillator, and sending an enable signal to the primary oscillator. | 12-29-2011 |
Patent application number | Description | Published |
20110106484 | THERMOMETER FOR DETERMINING THE TEMPERATURE OF AN ANIMAL'S EAR DRUM AND METHOD OF USING SAME - A thermometer for determining the temperature of an animal's ear drum. The thermometer includes a probe, an infrared-radiation detector adapted to receive infrared radiation emitted by the ear drum, and devices that help insure that the probe is disposed in a desired position in the ear canal so as to optimize the infrared radiation received from the ear drum, and to minimize the infrared radiation received from other ear parts. A method of using the thermometer is also disclosed. | 05-05-2011 |
20120150051 | BLOOD PRESSURE CUFF - A blood pressure cuff is defined by a first sheet and a second sheet. The first sheet has a first interior-inflatable surface attached to a second interior-inflatable surface of the second sheet to form an interior-inflatable portion between the first sheet and second sheet. The interior-inflatable portion is in communication with an opening to fluidly interconnect the interior-inflatable portion with an exterior of the cuff. A textured surface is included on the second interior-inflatable surface. | 06-14-2012 |
20130245457 | SYSTEMS AND METHODS FOR DETERMINING PATIENT TEMPERATURE - A temperature probe includes a handle and a shaft extending from the handle. The shaft includes a distal end, a proximal end, and a tip at the distal end. The temperature probe also includes a capacitance sensor disposed on one of the handle and the shaft, the capacitance sensor configured to measure a change in capacitance when positioned proximate a conductor. The temperature probe further includes a temperature sensor disposed on the shaft, the temperature sensor configured to measure a body cavity temperature of a patient. | 09-19-2013 |
20130245489 | SYSTEMS AND METHODS FOR DETERMINING PATIENT TEMPERATURE - A temperature probe includes a handle and a shaft extending from the handle. The shaft includes a distal end, a proximal end, and a tip at the distal end. The temperature probe also includes a capacitance sensor disposed on one of the handle and the shaft, the capacitance sensor configured to measure a change in capacitance when positioned proximate a conductor. The temperature probe further includes a temperature sensor disposed on the shaft, the temperature sensor configured to measure a body cavity temperature of a patient. | 09-19-2013 |
Patent application number | Description | Published |
20110071838 | SYSTEM AND METHODS FOR RECOGNIZING SOUND AND MUSIC SIGNALS IN HIGH NOISE AND DISTORTION - A method for recognizing an audio sample locates an audio file that most closely matches the audio sample from a database indexing a large set of original recordings. Each indexed audio file is represented in the database index by a set of landmark timepoints and associated fingerprints. Landmarks occur at reproducible locations within the file, while fingerprints represent features of the signal at or near the landmark timepoints. To perform recognition, landmarks and fingerprints are computed for the unknown sample and used to retrieve matching fingerprints from the database. For each file containing matching fingerprints, the landmarks are compared with landmarks of the sample at which the same fingerprints were computed. If a large number of corresponding landmarks are linearly related, i.e., if equivalent fingerprints of the sample and retrieved file have the same time evolution, then the file is identified with the sample. The method can be used for any type of sound or music, and is particularly effective for audio signals subject to linear and nonlinear distortion such as background noise, compression artifacts, or transmission dropouts. The sample can be identified in a time proportional to the logarithm of the number of entries in the database; given sufficient computational power, recognition can be performed in nearly real time as the sound is being sampled. | 03-24-2011 |
20120221131 | Systems and Methods for Recognizing Sound and Music Signals in High Noise and Distortion - A method for recognizing an audio sample locates an audio file that closely matches the audio sample from a database indexing a large set of original recordings. Each indexed audio file is represented in the database index by a set of landmark timepoints and associated fingerprints. Landmarks occur at reproducible locations within the file, while fingerprints represent features of the signal at or near the landmark timepoints. To perform recognition, landmarks and fingerprints are computed for the unknown sample and used to retrieve matching fingerprints from the database. For each file containing matching fingerprints, the landmarks are compared with landmarks of the sample at which the same fingerprints were computed. If a large number of corresponding landmarks are linearly related, i.e., if equivalent fingerprints of the sample and retrieved file have the same time evolution, then the file is identified with the sample. | 08-30-2012 |
20130138442 | Systems and Methods for Recognizing Sound and Music Signals in High Noise and Distortion - A method for recognizing an audio sample locates an audio file that closely matches the audio sample from a database indexing a large set of original recordings. Each indexed audio file is represented in the database index by a set of landmark timepoints and associated fingerprints. Landmarks occur at reproducible locations within the file, while fingerprints represent features of the signal at or near the landmark timepoints. To perform recognition, landmarks and fingerprints are computed for the unknown sample and used to retrieve matching fingerprints from the database. For each file containing matching fingerprints, the landmarks are compared with landmarks of the sample at which the same fingerprints were computed. If a large number of corresponding landmarks are linearly related, i.e., if equivalent fingerprints of the sample and retrieved file have the same time evolution, then the file is identified with the sample. | 05-30-2013 |
20140316787 | Systems and Methods for Recognizing Sound and Music Signals in High Noise and Distortion - A method for recognizing an audio sample locates an audio file that closely matches the audio sample from a database indexing a large set of original recordings. Each indexed audio file is represented in the database index by a set of landmark timepoints and associated fingerprints. Landmarks occur at reproducible locations within the file, while fingerprints represent features of the signal at or near the landmark timepoints. To perform recognition, landmarks and fingerprints are computed for the unknown sample and used to retrieve matching fingerprints from the database. For each file containing matching fingerprints, the landmarks are compared with landmarks of the sample at which the same fingerprints were computed. If a large number of corresponding landmarks are linearly related, i.e., if equivalent fingerprints of the sample and retrieved file have the same time evolution, then the file is identified with the sample. | 10-23-2014 |
Patent application number | Description | Published |
20090054619 | Functionalization of polyglycolides by "click" chemistry - Poly(glycolide) polymers are disclosed. The polymers generally include a polymerized alkynyl-substituted glycolide having a polymer backbone with one or more alkynyl groups appended thereto. The alkynyl groups provide reactive sites for further functionalization of the polymer, for example by reaction with azide derivatives (e.g., azide-substituted organic compounds). Alkynyl and azide groups react via the “click” chemistry mechanism to form functional groups covalently bonded to the polymer via a triazole link. The polymers are biodegradable and can be used to deliver drugs or other therapeutic substances (e.g., large biomolecules such as single strand RNA) at targeted locations in a patient's body and/or at controlled release rates. | 02-26-2009 |
20090325292 | Functional polyglycolide nanoparticles derived from unimolecular micelles - Poly(glycolide) polymers are disclosed. The polymers generally include a glycolide-based polymer backbone that includes one or more functional groups such as alkynyl groups, hydrophilic organic triazole groups, hydrophobic organic triazole groups (also including amphiphilic organic triazole groups), di-triazole organic crosslinking groups, and triazole-substituted drug derivatives. The alkynyl groups provide reactive sites for further functionalization of the polymer, for example by reaction with azide derivatives. The polymers can further encapsulate a drug for delivery to a patient (i.e., as compared to drug derivatives that are covalently attached to the polymer). The polymers can be in the form of thermodynamically stable unimolecular micelles or crosslinked nanoparticles. The polymer compositions are completely biodegradable and hold great potential for use in biomedical applications. | 12-31-2009 |
20100041902 | Cyclic alkyl substituted glycolides and polylactides therefrom - Cyclic alkyl, particularly cyclohexyl, substituted glycolides and polylactides are described. The polylactides have a high glass transition temperature and improved clarity. | 02-18-2010 |
20150065743 | METHODS FOR PRODUCING BORYLATED ARENES - Methods for the selective borylation of arenes, including arenes substituted with an electron-withdrawing group (e.g., 1-chloro-3-fluoro-2-substituted benzenes) are provided. The methods can be used, in some embodiments, to efficiently and regioselectively prepare borylated arenes without the need for expensive cryogenic reaction conditions. | 03-05-2015 |
20160090390 | SYNTHETIC METHODS FOR DIBORON REAGENTS AND RELATED COMPOUNDS - The disclosure is directed to diboron compounds, related methods of making, and related intermediate boron and diboron compounds used to make the same. The diboron compounds can be used as reagents to prepare chemical intermediates that are used in pharmaceutical, agrochemical, and specialty electronics industries. The disclosed processes and compounds provide simplified synthetic paths that significantly reduce steps, improve scalability, and minimize costs for producing the diboron reagents. | 03-31-2016 |
Patent application number | Description | Published |
20100025069 | Cable and a method of assembling same - A cable for encasing one or more wires includes at least one wire, a tube surrounding the at least one wire, and a conductive braid surrounding the tube. The cable further includes a jacket surrounding the conductive braid, wherein the jacket is formed from an abrasion-proof heat-flame resistant material. | 02-04-2010 |
20100027942 | Cable connector assembly - A cable connector assembly includes a fitting having first and second fitting ends and a fitting opening therethrough, wherein the fitting is formed from a conductive material. The cable connector assembly further includes a ferrule having first and second ferrule ends, a ferrule opening therethrough, and one or more teeth disposed axially along the ferrule opening, wherein the ferrule is formed from a conductive material. The first ferrule end is disposed over the second fitting end. The cable connector assembly further includes a tube including an outer nonconductive layer and an inner conductive layer. The tube is disposed between the second fitting end and the first ferrule end and the ferrule is secured around the fitting so that at least one of the one or more teeth pierce the outer nonconductive layer and make contact with the inner conductive layer to create an EMI/RFI shield across the fitting, the ferrule, and the tube. | 02-04-2010 |
20100029113 | Cable connector assembly - A cable connector assembly includes a fitting having first and second fitting ends and a fitting opening therethrough and an insert having first and second insert ends and an insert opening therethrough. The insert is disposed within the first fitting end. The cable connector assembly further includes a key structure disposed within the insert opening. The key structure extends axially past ends of one or more wire contacts disposed within the insert opening toward the first insert end. The key structure is aligned with a corresponding structure on a mating connector to allow attachment of the mating connector to the cable connector assembly without damage to the contacts. | 02-04-2010 |
Patent application number | Description | Published |
20140144050 | Internally Illuminated Footwear Component - The sole section of a shoe includes a midsole and an outsole, with the midsole being made from a translucent material. An illumination system is located inside the translucent midsole, causing the translucent midsole to be internally illuminated when the illumination system is active. Due to the translucent nature of the midsole light from the illumination system reflects internally throughout the midsole, increasing illumination. The light will also illuminate adjacent translucent components, such as the outsole if it is also made from a translucent material. Light from the illumination system can be blocked, such as by an opaque outsole or colored mold injection, and used to form an illuminated design or logo. By blacking out or covering sections of the translucent midsole, shapes and letters of visible light can be created in the negative space of the obstruction sections. This allows illuminated designs to easily be incorporated into footwear. | 05-29-2014 |
20140183071 | Shake Me & Look Inside, Interactive Footwear Container - A shoe box is specifically designed to display a light-up footwear. The shoe box has a base, a lateral section, and a cover which create a footwear receiving volume in which the light-up footwear is placed. A viewing port on the lateral section allows a consumer to view the interior of the container, allowing them to see the light-up footwear in a dark environment. A visual instruction on the lateral surface next to the viewing port provides instructions on how to use the shoe box. Shaking the shoe box causes vibration which is detected by a trigger system of the light-up footwear. The trigger system activates an illumination system of the light-up footwear, allowing a consumer to see the full effect of the light-up footwear in a dark environment by looking through the viewing port. | 07-03-2014 |
20140185275 | Internally Illuminated Light Diffusing Footwear - An illumination system is housed in a footwear, the footwear including a sole and an upper. A structure and a liner form inner layers connected to the upper. A plurality of illumination sources are electrically connected to a power source and positioned adjacent to the liner. The illumination sources are positioned between the liner and upper. A batting is designed to be light diffusing, while the upper has a light diffusing section. The light emitted from the plurality of illumination sources is diffused as it passes through the batting and light diffusing section. Aesthetic designs can be creating, either through the arrangement of the plurality of illumination sources or the provision of a light impermeable section on the upper. The light impermeable section, in combination with the light diffusion section, can be used to form or outline an aesthetic design. The result is an internally illuminated footwear with diffused light. | 07-03-2014 |
20150052780 | Internally Illuminated Footwear Component - The sole section of a shoe includes a midsole and an outsole, with the midsole being made from a translucent material. An illumination system is located inside the translucent midsole, causing the translucent midsole to be internally illuminated when the illumination system is active. Due to the translucent nature of the midsole light from the illumination system reflects internally throughout the midsole, increasing illumination. The light will also illuminate adjacent translucent components, such as the outsole if it is also made from a translucent material. Light from the illumination system can be blocked, such as by an opaque outsole or colored mold injection, and used to form an illuminated design or logo. By blacking out or covering sections of the translucent midsole, shapes and letters of visible light can be created in the negative space of the obstruction sections. This allows illuminated designs to easily be incorporated into footwear. | 02-26-2015 |
20150181973 | Internally Illuminated Footwear Component - The sole section of a shoe includes a midsole and an outsole which form a translucent sole section. The translucent midsole and translucent outsole are integrally molded with a translucent upper to create a fully translucent jelly footwear. An illumination system is located inside the translucent sole section, causing the jelly footwear to be internally illuminated when the illumination system is active. Due to the translucent nature of the midsole light from the illumination system reflects internally throughout the midsole, increasing illumination. The light will also illuminate the adjacent translucent outsole and translucent upper. Light from the illumination system can be blocked, such as by a colored mold injection, creating an illuminated design or logo. By blacking out or covering sections of the translucent outsole, shapes and letters of visible light can be created in the resulting negative space. This allows illuminated designs to easily be incorporated into footwear. | 07-02-2015 |
Patent application number | Description | Published |
20090254445 | SYSTEMS AND METHODS FOR AGGREGATING PACKAGES IN A SHIPPING ENVIRONMENT - Various embodiments for aggregating packages into a pouch in a shipping environment are disclosed. For example, package details associated with a package are compared to one or more incompatibility factors, and if the package details do not match the one or more incompatibility factors, a package identifier uniquely identifying the package is added to a pouch manifest. If the package is not compatible with the pouch, an error message may be displayed to a user indicating that the package is incompatible. In addition, package details may be compared with compatibility factors identifying criteria for packages that are compatible with the pouch and questionable compatibility factors identifying criteria for packages that may be compatible with the pouch. Compatibility factors and questionable compatibility factors may include, for example, service options, delivery notification options, or destination zip code(s). | 10-08-2009 |
20100131420 | APPARATUS, SYSTEMS AND METHODS FOR ONLINE, MULTI-PARCEL, MULTI-CARRIER, MULTI-SERVICE PARCEL RETURNS SHIPPING MANAGEMENT - The present invention provides a computer system (the “System”, or the “Return System”) that is configured and programmed to provide online stores with a fast, simple, convenient way for eCommerce customers of an online store to return merchandise purchased from that store from within that online store. The Return System provides multi-carrier shipment rating, shipment labeling, shipment tracking, shipment tracking management reports, returns analysis and returns management reporting In an exemplary embodiment, the Return System has three major components: 1.) A Returns Manager Subsystem that provides a user interface to each Merchant to setup the Merchant's account, setup the Merchant's return policy and rules, and to monitor the status and movement of return shipments; 2.) A Consumer Returns Subsystem (also sometimes referred to as a “Customer Returns Subsystem”) that provides each consumer using the Returns System with an online user interface that leads the consumer through the returns process, displays the return policies and rules to the consumer, provides shipping document to ship the return package if appropriate, and permits the consumer to track their return shipments; and 3.) a Returns Processing Subsystem that, in the exemplary embodiment, provides background shipping and tracking functionality. In one exemplary embodiment of the present invention, the Online Merchant integrates the Merchant's online system with the Returns Processing Subsystem. In another exemplary embodiment, the Returns Processing Subsystem is provided as an independent web-based application service (referred to as a “Return Merchant Service System”) operated by a common provider. In such an embodiment, the Merchant's system interacts with the Return Merchant Service System through Application Program Interfaces (“API”). | 05-27-2010 |
20110246384 | Apparatus, Systems and Methods For Online, Multi-Parcel, Multi-Carrier, Multi-Service Enterprise Parcel Shipping Management - The present invention provides a plurality of Enterprises with a single online user interface with which the Enterprise can provide Enterprise Shippers, shipping origination users and shipping intermediary users with an automated parcel management system for a plurality of supported Carriers for a plurality of services. The present invention provides for the hierarchical definition of users, including the establishment of at least one user for each Enterprise as a Super-Administrator with the highest level of privileges and authority for the Enterprise, and the identification of other users as Sub-Administrators, Desktop Users and Shipping Station Users. The present invention also provides for the hierarchical definition of organizational units within each Enterprise, including the definition of sites, groups within a site, and users within a group. The present invention further provides for a distinct definition of policies, privileges, and other types of specifications for each user level, each user, and each organizational unit. The present invention applies the user and organizational policies, privileges and other specifications as they apply to each particular user to drive the interactive interface with each particular user and to provide among other things, shipping options, shipping services, shipping rates, traveler and/or shipping label preparation, and shipment tracking. | 10-06-2011 |
20130179361 | Apparatus, Systems and Methods for Online, Multi-Parcel, Multi-Carrier, Multi-Service Enterprise Parcel Shipping Management - The present invention provides a plurality of Enterprises with a single online user interface with which the Enterprise can provide Enterprise Shippers, shipping origination users and shipping intermediary users with an automated parcel management system for a plurality of supported Carriers for a plurality of services. The present invention provides for the hierarchical definition of users, including the hierarchical definition of organizational units within each Enterprise. The present invention further provides for a distinct definition of policies, privileges, and other types of specifications for each user level, each user, and each organizational unit. The present invention applies the user and organizational policies, privileges and other specifications as they apply to each particular user to drive the interactive interface with each particular user and to provide among other things, shipping options, shipping services, shipping rates, traveler and/or shipping label preparation, and shipment tracking. | 07-11-2013 |
20140337246 | Apparatus, Systems and Methods for Online, Multi-Parcel, Multi-Carrier, Multi-Service Enterprise Parcel Shipping Management - The present invention provides a plurality of Enterprises with a single online user interface with which the Enterprise can provide Enterprise Shippers, shipping origination users and shipping intermediary users with an automated parcel management system for a plurality of supported Carriers for a plurality of services. The present invention provides for the hierarchical definition of users, including the hierarchical definition of organizational units within each Enterprise. The present invention further provides for a distinct definition of policies, privileges, and other types of specifications for each user level, each user, and each organizational unit. The present invention applies the user and organizational policies, privileges and other specifications as they apply to each particular user to drive the interactive interface with each particular user and to provide among other things, shipping options, shipping services, shipping rates, traveler and/or shipping label preparation, and shipment tracking. | 11-13-2014 |