Patent application number | Description | Published |
20090118200 | Proline bis-amide orexin receptor antagonists - The present invention is directed to proline bis-amide compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved. | 05-07-2009 |
20090124603 | Diazepan Orexin Receptor Antagonists - The present invention is directed to diazepan compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved. | 05-14-2009 |
20090176789 | Diazaspirodecane orexin receptor antagonists - The present invention is directed to diazaspirodecane compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved. | 07-09-2009 |
20100029736 | 2-SUBSTITUTED PROLINE BIS-AMIDE OREXIN RECEPTOR ANTAGONISTS - The present invention is directed to 2-substituted proline bis-amide compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved. | 02-04-2010 |
20100227848 | OXO BRIDGED DIAZEPAN OREXIN RECEPTOR ANTAGONISTS - The present invention is directed to oxo bridged diazepan compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved. | 09-09-2010 |
20110319409 | 7-AZA-QUINAZOLINE PDE10 INHIBITORS - The present invention is directed to 7-aza-quinazoline compounds of general structural formula I | 12-29-2011 |
Patent application number | Description | Published |
20100230988 | DUAL STAGE VARIABLE LOAD ENERGY ABSORBER FOR VEHICLE SEATING - A vehicle safety seat system includes a seat, and a frame and support surface that are movable with respect to each other between rest and attenuated positions, wherein the frame and support surface are respectively a first and second distance apart. A biasing mechanism biases the frame and support surface to the rest position between blast and slam down phases. A damper coupled between the frame and support surface has blast and rebound recovery resistance settings. The blast resistance setting is set to a predetermined value based on a weight of a seat occupant. The damper, during the blast phase, resists motion between the frame and support surface toward the attenuated position based upon the blast resistance setting, and after the blast phase and prior to the slam down phase, resists motion between the frame and support surface toward the rest position based upon the rebound recovery resistance setting. | 09-16-2010 |
20100230989 | DUAL STAGE VARIABLE LOAD ENERGY ABSORBER FOR VEHICLE SEATING - A vehicle safety seat system includes a seat, and a frame and support surface that are movable with respect to each other between rest and attenuated positions, wherein the frame and support surface are respectively a first and second distance apart. A biasing mechanism biases the frame and support surface to the rest position between blast and slam down phases. A damper coupled between the frame and support surface has blast and rebound recovery resistance settings. The blast resistance setting is set to a predetermined value based on a weight of a seat occupant. The damper, during the blast phase, resists motion between the frame and support surface toward the attenuated position based upon the blast resistance setting, and after the blast phase and prior to the slam down phase, resists motion between the frame and support surface toward the rest position based upon the rebound recovery resistance setting. | 09-16-2010 |
20140077519 | DUAL STAGE VARIABLE LOAD ENERGY ABSORBER FOR VEHICLE SEATING - A vehicle safety seat system includes a seat, and a frame and support surface that are movable with respect to each other between rest and attenuated positions, wherein the frame and support surface are respectively a first and second distance apart. A biasing mechanism biases the frame and support surface to the rest position between blast and slam down phases. A damper coupled between the frame and support surface has blast and rebound recovery resistance settings. The blast resistance setting is set to a predetermined value based on a weight of a seat occupant. The damper, during the blast phase, resists motion between the frame and support surface toward the attenuated position based upon the blast resistance setting, and after the blast phase and prior to the slam down phase, resists motion between the frame and support surface toward the rest position based upon the rebound recovery resistance setting. | 03-20-2014 |
Patent application number | Description | Published |
20140296912 | Tissure Closure Device and Method - A device that, when implanted in the heart, closes the wound and complies with wall motion (i.e., expands and contracts with the myocardium). | 10-02-2014 |
20140316458 | Tissure Closure Device and Method - A device having a plurality of anchors configured to be driven into a tissue, and a closure element extending between the anchors and configured to urge the anchors toward each other, closing a wound and complying with motion of the tissue. | 10-23-2014 |
20150209040 | SURGICAL STAPLING DEVICE AND METHOD - A surgical device comprises a base unit having a hydraulic controller and at least one control piston, a surgical end effector including at least one actuator piston, and a flexible shaft having at least one tube containing hydraulic fluid in hydraulic communication with the base unit and the surgical end effector. The hydraulic controller includes an electric motor configured to drive the control piston to generate hydraulic force. The hydraulic force is transferable from the base unit to the actuator piston of the surgical end effector through the hydraulic fluid in the at least one tube in the flexible shaft, such that the driving of the control piston by the electric motor under the control of the hydraulic controller transfers the hydraulic force from the control piston of the base unit to the actuator piston of the end effector in proportion to the ratio of the area of the control piston and the area of the actuator piston by metering the hydraulic fluid transferred by the control piston. | 07-30-2015 |
20150359627 | System and Method for Heart Valve Anchoring - A system and method for percutaneous heart valve replacement includes implanting a heart valve replacement prosthetic into tissue and driving anchors into the heart valve replacement to affix the prosthetic to the tissue. | 12-17-2015 |
20160095704 | Systems and Methods for Affixing A Prosthetic to Tissue - Systems and methods recited herein provide for affixation of a prosthetic valve to surrounding tissue, by at least one anchor and an anchor deployment device. The prosthetic valve device may be compliant with native tissue and may receive the at least one anchor in at least one anchor receptacle to affix the prosthetic valve to native tissue. The anchor may include a distal tip, a proximal head, and a tension component, such that upon deployment into tissue the tension component is situated in a tensioned state to exert a pulling force on the distal end of the anchor. | 04-07-2016 |