Patent application number | Description | Published |
20090275519 | Therapeutic peptidomimetic macrocycles - The present invention provides biologically active peptidomimetic macrocycles for the treatment of cell proliferative disorders such as cancer and immunoproliferative disease. | 11-05-2009 |
20100216688 | PEPTIDOMIMETIC MACROCYCLES - The present invention provides biologically active crosslinked polypeptides with improved properties relative to their corresponding precursor polypeptides, having good cell penetration properties and reduced binding to human proteins. The invention additionally provides methods of identifying and making such improved polypeptides. | 08-26-2010 |
20100298201 | PEPTIDOMIMETIC MACROCYCLES WITH IMPROVED PROPERTIES - The present invention provides biologically active peptidomimetic macrocycles with improved properties relative to their corresponding polypeptides. The invention additionally provides methods of preparing and using such macrocycles, for example in therapeutic applications. | 11-25-2010 |
20110223149 | PEPTIDOMIMETIC MACROCYCLES - The present invention provides biologically active peptidomimetic macrocycles with improved properties, such as protease resistance, relative to their corresponding polypeptides. The invention additionally provides methods of preparing and using such macrocycles, for example in therapeutic applications. | 09-15-2011 |
20120040889 | PEPTIDOMIMETIC MACROCYCLES - The present invention provides novel peptidomimetic macrocycles and methods of using such macrocycles for the treatment of viral disease. | 02-16-2012 |
20120149648 | THERAPEUTIC PEPTIDOMIMETIC MACROCYCLES - The present invention provides biologically active peptidomimetic macrocycles for the treatment of cell proliferative disorders such as cancer and immunoproliferative disease. | 06-14-2012 |
20120172311 | PEPTIDOMIMETIC MACROCYCLES - The present invention provides biologically active crosslinked polypeptides with improved properties relative to their corresponding precursor polypeptides, having good cell penetration properties and reduced binding to human proteins. The invention additionally provides methods of identifying and making such improved polypeptides. | 07-05-2012 |
20140135255 | PEPTIDOMIMETIC MACROCYCLES - The present invention provides biologically active crosslinked polypeptides with improved properties relative to their corresponding precursor polypeptides, having good cell penetration properties and reduced binding to human proteins. The invention additionally provides methods of identifying and making such improved polypeptides. | 05-15-2014 |
20150038430 | THERAPEUTIC PEPTIDOMIMETIC MACROCYCLES - The present invention provides biologically active peptidomimetic macrocycles for the treatment of cell proliferative disorders such as cancer and immunoproliferative disease. | 02-05-2015 |
20160068573 | PEPTIDOMIMETIC MACROCYCLES - The present invention provides novel peptidomimetic macrocycles and methods of using such macrocycles for the treatment of viral disease. | 03-10-2016 |
20160096873 | PEPTIDOMIMETIC MACROCYCLES - The present invention provides biologically active crosslinked polypeptides with improved properties relative to their corresponding precursor polypeptides, having good cell penetration properties and reduced binding to human proteins. The invention additionally provides methods of identifying and making such improved polypeptides. | 04-07-2016 |
20160101145 | PEPTIDOMIMETIC MACROCYCLES AND FORMULATIONS THEREOF - Aqueous pharmaceutical formulations, for parenteral administration, comprising peptidomimetic macrocycle or a pharmaceutically acceptable salt thereof wherein the peptidomimetic macrocycle binds to MDM2 and/or MDMX proteins are disclosed. Also disclosed are methods of treating diseases and disorders using the aqueous pharmaceutical formulations disclosed herein. | 04-14-2016 |
Patent application number | Description | Published |
20100129780 | ATHLETIC PERFORMANCE RATING SYSTEM - In one embodiment, the present invention is directed to an athleticism rating method for normalizing and more accurately comparing overall athletic performance of at least two athletes. Each athlete completes at least two different athletic performance tests. Each test is designed to measure a different athletic skill that is needed to compete effectively in a defined sport. The results from each test for a given athlete are normalized by comparing the test results to a database providing the distribution of test results among a similar class of athletes and then assigning each test result a point number based on that test result's percentile among the distribution of test results. Combining the point numbers derived from the at least two different athletic performance tests for an athlete produces an athleticism rating score representing the overall athleticism of each athlete. | 05-27-2010 |
20120130514 | ATHLETIC PERFORMANCE RATING SYSTEM - In one embodiment, the present invention is directed to an athleticism rating method for normalizing and more accurately comparing overall athletic performance of at least two athletes. Each athlete completes at least two different athletic performance tests. Each test is designed to measure a different athletic skill that is needed to compete effectively in a defined sport. The results from each test for a given athlete are normalized by comparing the test results to a database providing the distribution of test results among a similar class of athletes and then assigning each test result a point number based on that test result's percentile among the distribution of test results. Combining the point numbers derived from the at least two different athletic performance tests for an athlete produces an athleticism rating score representing the overall athleticism of each athlete. | 05-24-2012 |
20120130515 | ATHLETIC PERFORMANCE RATING SYSTEM - In one embodiment, the present invention is directed to an athleticism rating method for normalizing and more accurately comparing overall athletic performance of at least two athletes. Each athlete completes at least two different athletic performance tests. Each test is designed to measure a different athletic skill that is needed to compete effectively in a defined sport. The results from each test for a given athlete are normalized by comparing the test results to a database providing the distribution of test results among a similar class of athletes and then assigning each test result a point number based on that test result's percentile among the distribution of test results. Combining the point numbers derived from the at least two different athletic performance tests for an athlete produces an athleticism rating score representing the overall athleticism of each athlete. | 05-24-2012 |
20130079907 | GOLF ATHLETICISM RATING SYSTEM - Aspects of this disclosure relate to systems and methods for rating the performance of an athlete, particularly a golf athlete. The systems and method may include instructing the user to perform multiple golf-relevant athleticism drills or tests such as a stepping exercise, a broad jump, a wood-chop bounce, a countermovement lateral hop and/or a side-sling object launch. One or more drills or tests may be performed in a hip-neutral manner so as to simulate a golfer's stance. The performance data collected from each of these tests may be input into a processing system to generate an athleticism rank and score for each test as well as an overall, multi-factorial rating of golf athleticism. | 03-28-2013 |
Patent application number | Description | Published |
20090036686 | PREPARATION AND USE OF 2-SUBSTITUTED-5-OXO-3-PYRAZOLIDINECARBOXYLATES - A method is disclosed for preparing a 2-substituted-5-oxo-3-pyrazolidinecarboxylate compound of Formula I | 02-05-2009 |
20090054647 | Method for Preparing Substituted Pyrimidines - Disclosed a method for preparing a compound of Formula 1, | 02-26-2009 |
20100029950 | NOVEL SUBSTITUTED 1H-DIHYDROPYRAZOLES, THEIR PREPARATION AND USE - This invention provides compounds of Formula I, methods for their preparation and use for preparing compounds of Formula II | 02-04-2010 |
20100063287 | PROCESS FOR PREPARING 2-AMINO-5-CYANOBENZOIC ACID DERIVATIVES - Disclosed is a method for preparing a compound of Formula 1 comprising (1) contacting a compound of Formula 2, with (2) at least one alkali metal cyanide and (3) at least one compound of Formula 4 | 03-11-2010 |
20100249424 | METHOD FOR PREPARING 5-HALOALKYL-4,5-DIHYDROISOXAZOLE DERIVATIVES - Disclosed is a method for preparing a compound of Formula 1 | 09-30-2010 |
20100280251 | PROCESS FOR PREPARING 2-AMINO-5-CYANOBENZOIC ACID DERIVATIVES - Disclosed is a method for preparing a compound of Formula 1 comprising contacting a compound of Formula 2 with a metal cyanide reagent, a copper(I) salt reagent, an iodide salt reagent and at least one compound of Formula 3 | 11-04-2010 |
20110009638 | METHOD FOR PREPARING 3-TRIFLUOROMETHYL CHALCONES - Disclosed is a method for preparing a compound of Formula 1 wherein Q and Z are as defined in the disclosure comprising distilling water from a mixture comprising a compound of Formula 2, a compound of Formula 3, a base comprising at least one compound selected from the group consisting of alkaline earth metal hydroxides of Formula 4 wherein M is Ca, Sr or Ba, alkali metal carbonates of Formula 4a wherein M | 01-13-2011 |
20120277442 | METHOD FOR PREPARING 5-HALOALKYL-4, 5-DIHYDROISOXAZOLE DERIVATIVES - Disclosed is a method for preparing a compound of Formula 1 | 11-01-2012 |
20130165663 | METHOD FOR PREPARING 5-HALOALKYL-4, 5-DIHYDROISOXAZOLE DERIVATIVES - Disclosed is a method for preparing a compound of Formula 1 | 06-27-2013 |
20140155617 | METHOD FOR PREPARING 3-TRIFLUOROMETHYL CHALCONES - Disclosed is a method for preparing a compound of Formula 1 wherein Q and Z are as defined in the disclosure comprising distilling water from a mixture comprising a compound of Formula 2, a compound of Formula 3, a base comprising at least one compound selected from the group consisting of alkaline earth metal hydroxides of Formula 4 wherein M is Ca, Sr or Ba, alkali metal carbonates of Formula 4a wherein M | 06-05-2014 |
20150210654 | METHOD FOR PREPARING 3-TRIFLUOROMETHYL CHALCONES - Disclosed is a method for preparing a compound of Formula 1 wherein Q and Z are as defined in the disclosure comprising distilling water from a mixture comprising a compound of Formula 2, a compound of Formula 3, a base comprising at least one compound selected from the group consisting of alkaline earth metal hydroxides of Formula 4 wherein M is Ca, Sr or Ba, alkali metal carbonates of Formula 4a wherein M | 07-30-2015 |
Patent application number | Description | Published |
20110242720 | MAGNETIC CORE COUPLING IN A CURRENT TRANSFORMER WITH INTEGRATED MAGNETIC ACTUATOR - A system comprising a magnetic actuator, a current transformer and operational electronics in a dual-coil circuit breaker. The system includes an inline, but non concentric, implementation of the primary and secondary coils to maintain a narrow width suitable for retrofitting in standard industrial rack mounted enclosures. The system further comprises an I-shaped lamination stack that is designed to abut on the ends of an upper and lower plate of the current transformer. The I-shaped lamination stack significantly increases the overlap between the lamination and the upper and lower plates, which results in lower magnetic reluctance and improves magnetic coupling. | 10-06-2011 |
20110267722 | COST EFFECTIVE DESIGN FOR A CURRENT TRANSFORMER WITH AN INTEGRATED MAGNETIC ACTUATOR - A system comprising a magnetic actuator, a current transformer and operational electronics in a dual-coil circuit breaker. The system includes an inline, but non concentric, implementation of the primary and secondary coils to maintain a narrow width suitable for retrofitting in standard industrial rack mounted enclosures. The system further comprises a split core design that is integrated into an upper and lower plate which slide together and are retained by a secondary coil bobbin. Typically, the two parts of the split core can be manufactured into net shapes by utilizing a powder metal or metal injection molding process. Moreover, the split core design disclosed herein can reduce costs and time associated with manufacturing and assembly of the current transformer. | 11-03-2011 |
20130118296 | ELONGATE SHAFT FOR USE WITH HANDLE ASSEMBLY - A handle assembly and related methods for actuating a mechanism such as a disconnect switch. | 05-16-2013 |
20150016875 | METHOD AND APPARATUS TO ATTACH DEVICE TO DIN RAIL - Apparatus and methods for attaching and detaching a device to and from a DIN rail, the apparatus includes a housing carrier with a coupling assembly. The coupling assembly including one or more operator links, the one or more operator links rotatable relative to the housing carrier about a pivot, and the coupling assembly includes at least one DIN rail catch. The operator links have a first position in which the at least one DIN rail catch is in a first coupled position, and the operator links have a second position in which the at least one DIN rail catch is in a second uncoupled position. The operator links are operable to move the at least one DIN rail catch from the first coupled position to the second uncoupled position when the operator link is rotated about the pivot. | 01-15-2015 |
20150091557 | HALL EFFECT SENSOR CORE WITH MULTIPLE AIR GAPS - A hall effect current sensor including a mounting bracket, a sensor assembly, and a sensor core. The sensor assembly includes a flux sensor. The sensor core includes a first portion and a second portion. The first portion and the second portion define a first air gap and a second air gap between the first portion and the second portion. The first air gap is adapted to receive the sensor assembly. | 04-02-2015 |
Patent application number | Description | Published |
20090094820 | Contractor Assembly With Arc Steering System - A contactor assembly includes a stationary contact, an arc contact, an arc arrestor, and a magnetic intensifier. The magnetic intensifier is constructed to be secured in generally close proximity to the stationary contact. During communication of power through the contactor assembly, the magnetic intensifier accentuates a magnetic field associated with the stationary contact and increases the magnitude of a magnetic force directed to the arc arrestor. A pair of arc guides extend along the magnetic intensifier and, cooperatively with the magnetic force, ensure efficient, repeatable, and expedient transfer of a circuit termination arc to the arc arrestor. Such a construction increases the operable range and lifecycle of the contactor by reducing the damage associated with propagation of the circuit termination arc. | 04-16-2009 |
20090102585 | Contactor Assembly With Arc Steering System - A contactor assembly includes a stationary contact, an arc contact, an arc arrestor, and a magnetic intensifier. The magnetic intensifier is constructed to extend in generally close proximity to one of the stationary contact and the arc contact. During communication of power through the contactor assembly, the magnetic intensifier manipulates a magnetic field associated with current passing through the contactor assembly and increases the magnitude of a magnetic force directed to the arc arrestor. Preferably, the magnetic intensifier is formed integrally with a turnback associated with one of the stationary contact or the arc contact. Such a construction simplifies the manufacture and assembly of the contactor assembly and provides efficient and repeatable arc suppression. | 04-23-2009 |
20110133870 | Contactor Assembly With Arc Steering System - A contactor assembly includes a stationary contact, an arc contact, an arc arrestor, and a magnetic intensifier. The magnetic intensifier is constructed to be secured in generally close proximity to the stationary contact. During communication of power through the contactor assembly, the magnetic intensifier accentuates a magnetic field associated with the stationary contact and increases the magnitude of a magnetic force directed to the arc arrestor. A pair of arc guides extend along the magnetic intensifier and, cooperatively with the magnetic force, ensure efficient, repeatable, and expedient transfer of a circuit termination arc to the arc arrestor. Such a construction increases the operable range and lifecycle of the contactor by reducing the damage associated with propagation of the circuit termination arc. | 06-09-2011 |
Patent application number | Description | Published |
20130034984 | LATCH FOR A CARD EDGE CONNECTOR SYSTEM - A latch for securing a circuit card assembly to a circuit board mounted card edge connector includes first and second arms disposed on opposite ends of the card edge connector. The first and second arms define a reception space that receives the circuit card assembly. The first arm has a deflectable spring latch that is movable between a released position and a latched position. The circuit card assembly is secured by the spring latch in the latched position. The second arm has a latch hook that is configured to hook around and engage a portion of the circuit card assembly during mating of the circuit card assembly and the card edge connector. The latch hook defines a pivot point for pivoting the circuit card assembly into the card edge connector during mating of the circuit card assembly and the card edge connector. | 02-07-2013 |
20130210282 | Connector System Using Right Angle, Board-Mounted Connectors - A connector system having right angle, board-mounted header and receptacle connectors includes both a power interface and a signal interface for transmitting power and data signals there between. Optionally, the connectors may have features that allow the corresponding circuit boards to be offset. The connectors may have features that provide guidance for alignment of the header and receptacle connectors. The connectors may have features to enhance the electrical performance of the conductors defining the signal paths through the connector system. The connectors may have features that orient the components of the header and receptacle connectors for mounting to the circuit boards to maintain the true positions of the contacts for mounting to the circuit board. | 08-15-2013 |
20140148054 | RECEPTACLE ASSEMBLY HAVING A COMMONING CLIP WITH GROUNDING BEAMS - A receptacle assembly includes a front housing configured for mating with a header assembly. A plurality of contact modules are coupled to the front housing. Each contact module includes right and left conductive shells. Each conductive shell holds a frame assembly including a plurality of contacts that extend from the conductive shell for electrical termination. A commoning clip is coupled to the plurality of contact modules. The commoning clip has grounding beams extending forward of the right and left conductive shells for electrical connection to header shields of the header assembly. The commoning clip includes a plurality of openings in a rear thereof with barbs along sides of the openings. Each opening receives right and left conductive shells of a corresponding contact module with the barbs engaging the right and left shells to electrically connect the commoning clip to both the right and left shells of each contact module. | 05-29-2014 |
20150064968 | RECEPTACLE ASSEMBLY HAVING A PLURALITY OF TERMINATION POINTS - A receptacle assembly includes a contact module having a conductive holder and a frame assembly held by the conductive holder. The conductive holder has a first holder member and second holder member coupled to the first holder member. The conductive holder has a chamber between the first and second holder members divided into a plurality of channels by first tabs of the first holder member and second tabs of the second holder member. The first tabs have posts extending therefrom and the second tabs have holes receiving the posts of the first tabs. Each post has a plurality of termination points with the corresponding tab. The first and second holder members are electrically connected to one another at the termination points. The first and second tabs pass between contacts of the frame assembly to provide electrical shielding therebetween. | 03-05-2015 |
20150140865 | PIN SPACERS FOR CONNECTOR ASSEMBLIES - A connector assembly includes a housing, a plurality of contact modules received in the housing, and a pin spacer coupled to the contact modules. Each contact module has a plurality of contacts each including a pin extending from a bottom of the corresponding contact module. The pin spacer has a plurality of pin holes extending through the pin spacer. The pin holes receive corresponding pins for mounting to the circuit board. The pin spacer holds relative positions of the pins. The pin spacer has side edges at opposite sides of the pin spacer and lugs extending from the top of the pin spacer proximate to the sides of the pin spacer. The lugs block entry into a space defined between the bottoms of the contact modules and the top of the pin spacer. | 05-21-2015 |
20150333439 | LATCH ASSEMBLIES FOR CONNECTOR SYSTEMS - A connector system includes a cartridge having a cavity configured to hold one or more connector modules therein. The cartridge has a port opening to the cavity. The cartridge receiving the one or more connector modules through the port. The connector system includes a release mechanism housed in the cavity. The release mechanism configured to eject the one or more connector modules when actuated. The connector system includes a release button exposed beyond the cartridge and operably coupled to the release mechanism. The release button being pressed to an actuated position to activate the release mechanism. The release button is configured to be in a locked position to avoid inadvertent activation thereof. | 11-19-2015 |
20150333441 | LATCH ASSEMBLIES FOR CONNECTOR SYSTEMS - A connector system includes a cartridge having at least one cavity configured to hold connector modules therein. The connector system also includes at least one slider latch housed in the cartridge. The at least one slider latch is movable in a longitudinal direction and has at least one groove configured to receive a cam of a corresponding connector module to secure the connector modules to the cartridge. The at least one slider latch has a biasing member operably coupled thereto. The biasing member biases the slider latch in a biasing direction. The biasing member forces the at least one slider latch to return to a latched position after the cam is received in the profiled groove. The connector system also includes a discharge mechanism configured to move a discharge slider. | 11-19-2015 |
20150333443 | LATCH ASSEMBLIES FOR CONNECTOR SYSTEMS - A connector system includes a cavity configured to hold a connector module. The cartridge has a port opening to the cavity. The cartridge removably receives the connector module through the port. The connector system also includes an ejector mechanism. The ejector mechanism has a slider latch movable in a longitudinal direction relative to the cartridge. The slider latch has a profiled groove configured to cam therein. The slider latch has a linear gear. The ejector mechanism includes a rotatable handle having a circular gear configured to engage the linear gear to cause the slider latch to move as the rotatable handle is rotated between a closed position and an open position. The profiled groove engages the cam to secure the connector module to the connector assembly when the rotatable handle is in the closed position and unlock the connector module when in the open position. | 11-19-2015 |