Patent application number | Description | Published |
20130252830 | ENHANCED GENE EXPRESSION - The present disclosure is directed to a novel, unexpected approach of expressing exogenous gene(s) at increased levels by predictably, optionally irreversibly, incorporating the gene(s) into a region of increased gene expression (RIDGE) on a chromosome of a host cell. This approach is accomplished by identification of RIDGE(s) and further by integration of integrase-specific sites (e.g., attP or attB) in the presence of or mediated by integrase. The approach renders a high level of gene expression; predictability of the location of the exogenous genes, elimination of genetic instability or unwanted phenotype; and reduction of time and cost in optimizing protein production in host cells, which will be every useful in the production of therapeutic, prophylactic, and diagnostic proteins. | 09-26-2013 |
20130254907 | HUMANIZED TRANSGENIC ANIMAL - This present invention relates to transgenic animals useful to study human diseases. Specifically, the invention relates to transgenic animals expressing at least two human proteins (optionally in replacement of the counterpart proteins in the animal) whereas a first human protein interacts with a second human protein. The transgenic animals can then be used for evaluating drugs or building disease models that are related to the expressed human proteins in the animals. The animals and methods disclosed herein reduce the possibility identifying a false-positive compound—the compound that show an effect in a naturally-occurring, non-transgenic animal but may not necessarily work or be therapeutic in human, since the compound may only interrupt the interaction between two animal proteins not necessarily two related human proteins. Also, the animals and methods disclosed herein reduce the possibility of identifying a false-negative compound—a compound that does not work or have any effect in a naturally-occurring, non-transgenic animal but may have therapeutic effect in human, since the compound may only interrupt the interaction between at least two relevant human proteins not necessarily two related animal proteins. | 09-26-2013 |
20150031575 | USES OF IDED NANOSTRUCTURES IN NUCLEIC ACID TECHNOLOGY - The present invention relates to compositions comprising a porous nanostructure of a known characteristics and a fragment of nucleic acid having a known sequence. Methods of use of the compositions were also provided, for example in DNA amplification, detection, and DNA sequencing. | 01-29-2015 |
20150051102 | MULTIFUNCTIONAL NANOPARTICLES FOR MOLECULAR AND CELLULAR SEPARATION, DETECTION AND QUANTIFICATION - The present disclosure provides compositions and methods useful for molecular and cellular separation, detection and quantification. The compositions provided herein comprise a nanostructure having magnetic property operably linked to an analyte-binding member. | 02-19-2015 |
Patent application number | Description | Published |
20140341066 | Communication Resource Allocation Systems and Methods - A channel descriptor management message is transmitted on a broadcast connection to a mobile terminal. The channel descriptor management message provides a format for a frame. The frame includes a resource space. The channel descriptor management message defines a plurality of channels within the resource space and allocates at least one of the channels to a plurality of users. Subsequent resource allocation messages may refer to a location within a channel rather than a location within the entire resource space. | 11-20-2014 |
20140348117 | Systems and Methods for Use with Orthogonal Frequency Division Multiplexing - Systems and methods are provided for enabling H-ARQ communication between a base station and one or more wireless terminals. Methods for enabling incremental redundancy (IR) based H-ARQ, Chase based H-ARQ and Space-Time Code combining (STC) based H-ARQ between devices for down-link and up-link direction transmissions are provided in the form of an information element (IE) for use with a Normal MAP convention as currently accepted in the draft version standard of IEEE 802.16. In addition, embodiments of the invention provide a resource management scheme to protect a network from abuse of resources from a wireless terminal not registered with the network. Components of the down-link and up-link mapping components of a data frame transmitted from the base station to one or more wireless terminals included messages that are readable by all wireless terminals as well as some messages that are encrypted and only readable by wireless terminals that are authenticated as being registered with the network. | 11-27-2014 |
20150036669 | Closed-Loop MIMO Systems and Methods - Methods, devices and systems are provided for transmitting and receiving MIMO signals. In one embodiment, transmitting of the MIMO signals involves pre-coding each of at least two data symbols using a respective pre-coding codeword to preclude a corresponding plurality of pre-coded data symbols. A respective signal is transmitted from each of a plurality of antennas, the respective signal including one of the pre-coded signals and at least one pilot for use in channel estimation. The signals collectively further include at least one beacon pilot vector consisting of a respective beacon pilot per antenna, the beacon pilot vector containing contents known to a receiver for use by the receiver in determining the codeword used to pre-code the at least one data signal. | 02-05-2015 |
20150065141 | Handoffs and Handoff Selection in a Wireless Access Network - The present invention facilitates handoffs for a mobile terminal in a wireless access network that is capable of supporting different types of handoffs. The different handoff types may include soft handoffs and fast base station switching (FBSS). In operation, context information associated with supporting wireless communications between the wireless access network and the mobile terminal are determined. Based on whether the context information is shared between base stations involved in the handoff or transferred from one base station to another of the base stations involved in the handoff, a particular handoff type is selected from the different handoff types that are available. Selecting the specific type of handoff to use may also be based on the level of context information that is available, the actual content of the context information, application preferences, channel conditions, base station or mobile terminal capabilities, or any combination thereof. | 03-05-2015 |
20150109990 | SYSTEM AND METHOD FOR SPATIAL MULTIPLEXING-BASED MULTIPLE ANTENNA BROADCAST/MULTICAST TRANSMISSION - Methods and devices are provided for implementing two types of sub-channel arrangements. A first type of sub-channel arrangement involves defining a first traffic portion and a second traffic portion of a transmission resource, transmitting broadcast traffic on at least one first antenna of a plurality of antennas in the first traffic portion using a first sub-channelization, transmitting multicast traffic on at least one second antenna of the plurality of antennas, the at least one second antenna being distinct from the at least one first antenna, in the first traffic portion using a second sub-channelization, and transmitting unicast traffic on at least one antenna of the plurality of antennas in the second traffic portion using a third sub-channelization. A second type of sub-channel arrangement involves defining a first traffic portion and a second traffic portion, wherein for a portion of the transmission resource, a portion of the first traffic portion overlaps with a portion of the second traffic portion. In the portion of the transmission resource in which a portion of the first traffic portion overlaps with a portion of the second traffic portion, the channel arrangement involves transmitting broadcast/multicast traffic on at least one first antenna of a plurality of antennas using a first sub-channelization and b) transmitting unicast traffic on at least one second antenna of the plurality of antennas, the at least one second antenna being distinct from the at least one first antenna, using a second sub-channelization. The first, second and third sub-channelizations may be based on either one of or a combination of FDM sub-channelization and TDM sub-channelization. | 04-23-2015 |
20150215921 | Methods And Systems For Enabling Feedback In Wireless Communication Networks - Aspects of the present invention provide additional MAC functionality to support the PHY features of a wireless communication system framework. The additional MAC functionality aids in enabling feedback from wireless terminals to base stations. In some aspects of the invention the feedback is provided on an allocated feedback channel. In other aspects of the invention the feedback is provided by MAC protocol data units (PDU) in a header, mini-header, or subheader. The feedback may be transmitted from the wireless terminal to the base station autonomously by the wireless terminal or in response to an indication from the base station that feedback is requested. Aspects of the invention also provide for allocating feedback resources to form a dedicated feedback channel. One or more of these enhancements is included in a given implementation. Base stations and wireless terminals are also described upon which methods described herein can be implemented. | 07-30-2015 |
20150270996 | Pilot Design for OFDM Systems with Four Transmit Antennas - Pilot, preamble and midamble patterns are provided that are particularly suited for four transmit antenna OFDM systems. Pilots are inserted in a scattered manner for each of the four antennas, either uncoded, space-time coded in pairs, space-time frequency coded in pairs, or space-time-frequency coded. | 09-24-2015 |
20160043816 | OFDM System with Reverse Link Interference Estimation - A new method of performing interference estimation to allow the data packets to be efficiently delivered in an OFDM system. The interference estimation is performed on average over each frame for each mobile station individually in both frequency and time domains. Based on the estimated interference, the CIR can be determined by the BTS based on channel response estimates made by the BTS, or by the MS based on channel response estimates made for the uplink assuming a symmetrical channel. Numerical results show that the CIR estimation error could be very small if a sub-channel is considered as the minimum transmission unit. In terms of the aggregate throughput, the interference estimation method can provide a significant gain. | 02-11-2016 |
20160099766 | Methods And Systems For Wireless Networks Relays - Methods and systems are provided for use with wireless networks having one or more cell in which each cell includes a base station (BS), at least one relay station (RS) and at least one mobile station (MS). The at least one relay station can be used as an intermediate station for providing communication between the BS and MS. Methods are provided for allocating OFDM resources for communicating between the BS, RS and/or MS for example dividing transmission resources into uplink and downlink transmissions and methods of inserting pilot symbols into | 04-07-2016 |
Patent application number | Description | Published |
20120194779 | Materials For Use In Ophthalmic Applications And Methods - A lens body comprising at least one form of boronic acid, boronic ester or boronic anhydride is provided. The lens body is contacted with a solution comprising at least one form of TRIS. A contact lens package including the contact lens, and methods of producing and using the contact lens, are also provided. | 08-02-2012 |
20120220688 | Phosphine-Containing Hydrogel Contact Lenses - Hydrogel contact lenses that are derived from a polymerizable composition including at least one hydrophilic monomer and at least one phosphine-containing component are described. The hydrogel of the contact lenses can be a silicone hydrogel or a non-silicone hydrogel. Use of polymerizable compositions comprising a phosphine-containing component can be cured under both inert and air atmospheres, and can be used to form hydrogel contact lenses having improved shape retention properties, having improved resistance to discoloration. Batches of hydrogel contact lenses and methods of making hydrogel contact lenses are also described. | 08-30-2012 |
20140131227 | Phosphine-Containing Hydrogel Contact Lenses - Hydrogel contact lenses that are derived from a polymerizable composition including at least one hydrophilic monomer and at least one phosphine-containing component are described. The hydrogel of the contact lenses can be a silicone hydrogel or a non-silicone hydrogel. Use of polymerizable compositions comprising a phosphine-containing component can be cured under both inert and air atmospheres, and can be used to form hydrogel contact lenses having improved shape retention properties, having improved resistance to discoloration. Batches of hydrogel contact lenses and methods of making hydrogel contact lenses are also described. | 05-15-2014 |
20150201042 | ADAPTIVE BITRATE MODIFICATION OF A MANIFEST FILE - A system includes a media optimizer that adaptively generates and transmits a modified manifest file based on an original manifest file corresponding to an associated media asset from a content provider in response to a media content request from a client for the associated media asset. The original manifest file specifies bitrates. The media optimizer extracts parameters associated with the media content request and applies bitrate policies based on the extracted parameters to adaptively modify the original manifest file to generate the modified manifest file. The media optimizer is further configured to transmit the modified manifest file to the client for selection by the client of a bitrate associated with delivery of the associated media asset. | 07-16-2015 |
Patent application number | Description | Published |
20080236621 | INTEGRATED WASHER AND STERILIZER - A method and apparatus provides for cleaning and sterilizing a device in one machine. The method comprises the steps of: a) placing the device into a container; b) placing the container into a washing/sterilization apparatus; c) the washing/sterilization apparatus washing the device by applying a washing fluid to an interior of the container to wash the device; d) after washing the device, and without removing the device from the washing/sterilization apparatus, the washing/sterilization apparatus packaging the device in a bacteria impermeable package; e) the washing/sterilization apparatus sterilizing the device by exposing the device to a sterilizing vapor; and f) removing the device while it remains in the package whereby to preserve its sterility until use. | 10-02-2008 |
20080236631 | WASHER AND DECONTAMINATOR WITH LID CONTROL - A method and apparatus provide for automatically cleaning and decontaminating medical instruments. The method comprising the steps of: a) placing the medical instruments into a container after their use in a medical procedure; b) closing the container to seal the instruments inside whereby to prevent personnel contact with the instruments and any contaminants which might be thereon; c) inserting the sealed container into a washer/decontaminator and sealing the washer/decontaminator; d) the washer/decontaminator automatically opening the container and applying a washing fluid thereto to wash the instruments within the container; and e) the washer/decontaminator automatically applying a disinfectant to the container to disinfect the instruments whereby to allow safe handling thereof by personnel. | 10-02-2008 |
20080240979 | CONTAINER STERILIZER WITH LID CONTROL - A method and apparatus provides for sterilizing a device in a container. The method comprising the steps of: a) placing the device into the container; b) processing the device, the container and a lid for the container in a sterilization process with the lid separated from the container; and c) after sterilizing a contact surface on the container where the lid meets the container, and while maintaining the container and the lid in a sterile environment, placing the lid onto the container, whereby to prevent contamination of the device upon its removal from the container via contact with the contact surface. | 10-02-2008 |
20090107529 | DELIVERY OF FLUID TO MEDICAL DEVICE LUMENS - A method and device provide for delivering fluid for cleaning and/or decontamination to a lumen in a medical device. A tube having a plurality of openings therethrough is inserted into the lumen of the medical device the fluid is flowed through the tube, out of the openings and into the lumen. | 04-30-2009 |
20090111895 | ENHANCED DIALDEHYDE DISINFECTANT AND STERILIZATION FORMULATIONS - High-level disinfectant formulations and sporicidal formulations suitable for use as chemical disinfection and sterilization mediums comprising a dialdehyde, a carboxylate salt in amount of from about 3 weight percent to about 20 weight percent, and the balance water. The formulations are useful for disinfecting and sterilizing medical instruments and medical equipment. | 04-30-2009 |
20100224224 | WASHER AND DECONTAMINATOR WITH LID CONTROL - A method and apparatus provide for automatically cleaning and decontaminating medical instruments. The method comprising the steps of: a) placing the medical instruments into a container after their use in a medical procedure; b) closing the container to seal the instruments inside whereby to prevent personnel contact with the instruments and any contaminants which might be thereon; c) inserting the sealed container into a washer/decontaminator and sealing the washer/decontaminator; d) the washer/decontaminator automatically opening the container and applying a washing fluid thereto to wash the instruments within the container; and e) the washer/decontaminator automatically applying a disinfectant to the container to disinfect the instruments whereby to allow safe handling thereof by personnel. | 09-09-2010 |
Patent application number | Description | Published |
20090275265 | ENDPOINT DETECTION IN CHEMICAL MECHANICAL POLISHING USING MULTIPLE SPECTRA - A computer implemented method includes obtaining at least one current spectrum with an in-situ optical monitoring system, comparing the current spectrum to a plurality of different reference spectra, and determining based on the comparing whether a polishing endpoint has been achieved for the substrate having the outermost layer undergoing polishing. The current spectrum is a spectrum of light reflected from a substrate having an outermost layer undergoing polishing and at least one underlying layer. The plurality of reference spectra represent spectra of light reflected from substrates with outermost layers having the same thickness and underlying layers having different thicknesses. | 11-05-2009 |
20100129939 | USING OPTICAL METROLOGY FOR WITHIN WAFER FEED FORWARD PROCESS CONTROL - A method of controlling the polishing of a substrate includes polishing a substrate on a first platen using a first set of parameters, obtaining first and second sequences of measured spectra from first and second regions of the substrate with an in-situ optical monitoring system, generating first and second sequences of values from the first and second sequences of measured spectra, fitting first and second linear functions to the first and second sequences of values, determining a difference between the first linear function and the second linear function, adjusting at least one parameter of a second set of parameters based on the difference, and polishing the substrate on a second platen using the adjusted parameter. | 05-27-2010 |
20100130100 | USING OPTICAL METROLOGY FOR WAFER TO WAFER FEED BACK PROCESS CONTROL - A method of controlling the polishing of a substrate includes polishing a substrate on a first platen using a first set of parameters, obtaining first and second sequences of measured spectra from first and second regions of the substrate with an in-situ optical monitoring system, generating first and second sequences of values from the first and second sequences of measured spectra, fitting first and second linear functions to the first and second sequences of values, determining a difference between the first linear function and the second linear function, adjusting at least one parameter of the first set of parameters based on the difference, and polishing the second substrate on the first platen using the adjusted parameter. | 05-27-2010 |
20100297916 | METHODS OF USING OPTICAL METROLOGY FOR FEED BACK AND FEED FORWARD PROCESS CONTROL - A method includes polishing a substrate on a first platen using a first set of parameters, obtaining a plurality of measured spectra from at least two zones, comparing the plurality of measured spectra with a reference spectrum to evaluate the thickness of each of the at least two zones of the substrate, comparing a thickness of a first zone with a thickness of a second zone, determining whether the thickness of the first zone falls within a predetermined range of the thickness of the second zone, and if the thickness does not fall within the predetermined range, at least one of a) adjusting at least one parameter of the first set and polishing a second substrate on the first platen using the adjusted parameters, or b) adjusting at least one parameter of a second set and polishing the substrate on a second platen using the adjusted parameters. | 11-25-2010 |
20120021672 | Tracking Spectrum Features In Two Dimensions For Endpoint Detection - A method of polishing includes polishing a substrate, receiving an identification of a selected spectral feature to monitor during polishing, measuring a sequence of spectra of light reflected from the substrate while the substrate is being polished, determining a location value and an associated intensity value of the selected spectral feature for each of the spectra in the sequence of spectra to generate a sequence of coordinates, and determining at least one of a polishing endpoint or an adjustment for a polishing rate based on the sequence of coordinates. At least some of the spectra of the sequence differ due to material being removed during the polishing, and the coordinates are pairs of location values and associated intensity values. | 01-26-2012 |
20120028377 | USING OPTICAL METROLOGY FOR WITHIN WAFER FEED FORWARD PROCESS CONTROL - A method of controlling the polishing of a substrate includes polishing a substrate on a first platen using a first set of parameters, obtaining first and second sequences of measured spectra from first and second regions of the substrate with an in-situ optical monitoring system, generating first and second sequences of values from the first and second sequences of measured spectra, fitting first and second linear functions to the first and second sequences of values, determining a difference between the first linear function and the second linear function, adjusting at least one parameter of a second set of parameters based on the difference, and polishing the substrate on a second platen using the adjusted parameter. | 02-02-2012 |
20120034845 | TECHNIQUES FOR MATCHING MEASURED SPECTRA TO REFERENCE SPECTRA FOR IN-SITU OPTICAL MONITORING - A method of controlling polishing includes storing a library having a plurality of reference spectra, polishing a substrate, measuring a sequence of spectra of light from the substrate during polishing, for each measured spectrum of the sequence of spectra, finding a best matching reference spectrum using a matching technique other than sum of squared differences to generate a sequence of best matching reference spectra, and determining at least one of a polishing endpoint or an adjustment for a polishing rate based on the sequence of best matching reference spectra. Finding a best matching reference spectrum may include performing a cross-correlation of the measured spectrum with each of two or more of the plurality of reference spectra from the library and selecting a reference spectrum with the greatest correlation to the measured spectrum as a best matching reference spectrum. | 02-09-2012 |