Patent application number | Description | Published |
20110053964 | 4-AMINOQUINAZOLINE DERIVATIVES AND METHODS OF USE THEREOF - This invention relates to novel 4-aminoquinazolines and pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering inhibitors of the EGFR and HER-2. | 03-03-2011 |
20130012565 | 4-HYDROXYBUTYRIC ACID ANALOGS - This invention relates to novel derivatives of 4-hydroxybutyric acid and prodrugs thereof, and pharmaceutically acceptable salts of the foregoing. This invention also provides pharmaceutical compositions comprising a compound of this invention and the use of such compositions in methods of treating narcolepsy, fibromyalgia, other disorders or conditions that are beneficially treated by improving nocturnal sleep or by administering sodium oxybate. | 01-10-2013 |
20140073667 | DEUTERATED CFTR POTENTIATORS - This invention relates to compounds of Formula I: | 03-13-2014 |
20140343119 | 4-HYDROXYBUTYRIC ACID ANALOGS - This invention relates to novel derivatives of 4-hydroxybutyric acid and prodrugs thereof, and pharmaceutically acceptable salts of the foregoing. This invention also provides pharmaceutical compositions comprising a compound of this invention and the use of such compositions in methods of treating narcolepsy, fibromyalgia, other disorders or conditions that are beneficially treated by improving nocturnal sleep or by administering sodium oxybate. | 11-20-2014 |
20150099780 | DEUTERATED CFTR POTENTIATORS - This invention relates to compounds of Formula I: | 04-09-2015 |
20150197525 | DEUTERATED DERIVATIVES OF RUXOLITINIB - The present invention in one embodiment provides a compound of Formula A: | 07-16-2015 |
20150210699 | Deuterated Ibrutinib - The present invention in one embodiment provides a compound of Formula (I); or a pharmaceutically acceptable salt thereof, wherein the variables shown in Formula (I) are as defined in the specification. | 07-30-2015 |
20150239896 | Deuterated Derivatives of Ruxolitinib - The present invention in one embodiment provides a compound of Formula A: | 08-27-2015 |
Patent application number | Description | Published |
20090172432 | Power management in electronic systems - In one embodiment, an electronic apparatus comprises at least one processor and a computer readable medium coupled to the processor and comprising logic instructions encoded in the computer readable medium, wherein the instructions, when executed in a processing system, cause the processing system to perform operations comprising initializing a direct memory access profiler in an electronic system, wherein the direct memory access is coupled to a policy manager in the electronic system, measuring at least one memory consumption characteristic of the electronic system, communicating the at least one memory consumption characteristic to a policy manager of the electronic system, and using the at least one memory consumption characteristic to adjust a power state of the electronic system. | 07-02-2009 |
20120166844 | POWER MANAGEMENT IN ELECTRONIC SYSTEMS - In one embodiment, an electronic apparatus comprises at least one processor and a computer readable medium coupled to the processor and comprising logic instructions encoded in the computer readable medium, wherein the instructions, when executed in a processing system, cause the processing system to perform operations comprising initializing a direct memory access profiler in an electronic system, wherein the direct memory access is coupled to a policy manager in the electronic system, measuring at least one memory consumption characteristic of the electronic system, communicating the at least one memory consumption characteristic to a policy manager of the electronic system, and using the at least one memory consumption characteristic to adjust a power state of the electronic system. | 06-28-2012 |
20140108830 | POWER MANAGEMENT IN ELECTRONIC SYSTEMS - In one embodiment, an electronic apparatus comprises at least one processor and a computer readable medium coupled to the processor and comprising logic instructions encoded in the computer readable medium, wherein the instructions, when executed in a processing system, cause the processing system to perform operations comprising initializing a direct memory access profiler in an electronic system, wherein the direct memory access is coupled to a policy manager in the electronic system, measuring at least one memory consumption characteristic of the electronic system, communicating the at least one memory consumption characteristic to a policy manager of the electronic system, and using the at least one memory consumption characteristic to adjust a power state of the electronic system. | 04-17-2014 |
Patent application number | Description | Published |
20120136378 | SUB-CORTICAL SUTURE CUTTER - An arthroscopic suture cutting device according to embodiments of the invention includes an outer tube; an inner rod including an outer surface and an aperture, a distalmost edge of a second distal opening located distally of a distalmost edge of a first distal opening, the inner rod can receive a suture extending through both distal openings; in a loading position, the inner rod extends distally of the outer tube to receive the suture; in an intermediate position, the distal openings are closer to the outer tube, such that the suture is permitted to slide through the aperture without release; and in a cut position, the distalmost edges of the distal openings are within the outer tube. Moving from intermediate position to cut position draws the suture between outer tube and inner rod, urging the inner rod radially toward the second distal opening, cutting the suture between the outer tube and the distalmost edge of the second distal opening. | 05-31-2012 |
20120143220 | SYSTEMS AND METHODS FOR SUTURE PASSAGE - A system for suture passage through a tissue according to embodiments of the present invention includes a suture snare, the suture snare comprising a resilient anchor element and a suture capture element, a substantially rigid passer tube, an actuator rod, a snare enclosure formed by the passer tube and actuator rod, the actuator rod movable to move the snare enclosure between a closed configuration which completely captures a portion of the suture snare and an open configuration which does not completely capture the portion of the suture snare, and a piercing tip configured to form a hole through the tissue, wherein at least one dimension of the resilient anchor element in an undeformed state is larger than a largest dimension of the hole, and the anchor element deforms during insertion of the resilient anchor element through the hole and substantially resumes its prior shape after passing through the hole. | 06-07-2012 |
20130131723 | BONE IMPLANT WITH CONVERTIBLE SUTURE ATTACHMENT - Some embodiments of the present invention include a suture anchor with both knotless and knotted suture attachment capabilities, as well as methods for loading the suture in knotless and knotted configurations. Some embodiments of the present invention include a suture anchor with an inner implant body with a spreader that slides in relation to an outer expandable collar, such that pushing the expandable collar distally with an inserter causes the spreader to expand the collar against the surrounding bone to secure the suture anchor in place. Such embodiments may also include a detachment or breakaway feature between the inserter and the suture anchor to permit separation after anchor deployment. Some embodiments of the present invention include methods for deploying such suture anchors and expanding the expandable collars and/or detaching the inserter tools. Embodiments of the present invention may be used in various orthopedic applications such as, for example, shoulder repair. | 05-23-2013 |
Patent application number | Description | Published |
20130072227 | Continuous Data Optimization of Moved Access Points in Positioning Systems - Methods and systems of continuously optimizing data in WiFi positioning systems. A location-based services system uses WiFi-enabled devices to monitor WiFi access points in a target area to indicate whether a WiFi access point has moved relative to its previously recorded location. A WiFi-enabled device communicates with WiFi access points within range of the WiFi-enabled device so that observed WiFi access points identify themselves; A reference database is accessed to obtain information specifying a recorded location for each observed WiFi access point in the target area. The recorded location information is used for each of the observed WiFi access points in conjunction with predefined rules to infer whether an observed WiFi access point has moved relative to its recorded location. The reference database is informed of the identity of any observed WiFi access point that is inferred to have moved. | 03-21-2013 |
20130340095 | Method of and Systems for Privacy Preserving Mobile Demographic Measurement of Individuals, Groups and Locations Over Time and Space - Disclosed are techniques for privacy preserving mobile demographic measurement of individuals, groups, and locations over time and space. A method of estimating demographic information associated with a user of a mobile device and/or a location while preserving the privacy of the user based at least in part on a location estimate of the mobile device of the user includes receiving an estimated geographical location of the mobile device of the user and receiving a time at which the mobile device was at the estimated geographical location. The method includes assigning substitute identifiers for the geographical location and the time at which the mobile device was at the estimated geographical location. The method includes associating the geographical areas substitute identifiers with demographic information and estimating demographic information associated with the user of the mobile device based on the substitute identifiers and based on the demographic information associated with substitute identifiers. | 12-19-2013 |
20140080510 | CONTINUOUS DATA OPTIMIZATION OF MOVED ACCESS POINTS IN POSITIONING SYSTEMS - Methods and systems of continuously optimizing data in WiFi positioning systems. A location-based services system uses WiFi-enabled devices to monitor WiFi access points in a target area to indicate whether a WiFi access point has moved relative to its previously recorded location. A WiFi-enabled device communicates with WiFi access points within range of the WiFi-enabled device so that observed WiFi access points identify themselves; A reference database is accessed to obtain information specifying a recorded location for each observed WiFi access point in the target area. The recorded location information is used for each of the observed WiFi access points in conjunction with predefined rules to infer whether an observed WiFi access point has moved relative to its recorded location. The reference database is informed of the identity of any observed WiFi access point that is inferred to have moved. | 03-20-2014 |
20140160963 | ESTIMATION OF SPEED AND DIRECTION OF TRAVEL IN A WLAN POSITIONING SYSTEM - A method for estimating the speed and bearing of a Wi-Fi enabled device using WLAN radio signals in a WLAN based location service is provided. A method used to estimate a speed of travel of a Wi-Fi enabled device comprises the Wi-Fi enabled device receiving signals transmitted by Wi-Fi access points in range of the Wi-Fi enabled device, and using the signals to estimate the speed of and/or direction of travel of the Wi-Fi enabled device. | 06-12-2014 |
20140176296 | METHODS AND SYSTEMS FOR MANAGING MOTION SICKNESS - Methods and systems are provided herein for reducing or eliminating motion sickness in users of devices, such as mobile devices, in a variety of environments, including methods and systems for sensing motion in the user's environment and providing feedback that encourages a user to orient in a motion-reducing manner. | 06-26-2014 |
20150019719 | MAPPING/TRANSLATION TECHNIQUES FOR GENERATING ASSOCIATIONS BETWEEN NETWORK ADDRESSES AND ATTRIBUTES THAT WERE NOT DIRECTLY OBSERVED - In one embodiment, a mapping/translation technique is provided for generating an association between an observed network address and one or more attributes that are not directly observed. A network address is observed that is associated with a source device. A first attribute is determined, the first attribute being a directly observed attribute. The first attribute is mapped to a second attribute based on at least a predefined spatial, temporal, or identity-related correspondence between the first attribute and the second attribute, wherein the second attribute was not directly observed in connection with the network address. An association is generated between the second attribute and the network address. A record that maintains the association between the second attribute and the network address is stored. | 01-15-2015 |
20150019720 | DETERMINING FIXED/MOBILE AND PROXY/NON-PROXY NETWORK ADDRESSES - In one embodiment, a processing technique is provided for determining a refined attribute of a network address based on one or more other attributes. A network address associated with a source device in communication with a network is observed. One or more first attributes of the network address are determined, where the one or more first attributes indicate at least a spatial or temporal property of the network address. The one or more first attributes are processed to determine a second attribute to be associated with the network address, where the second attribute indicates whether the network address is a fixed or mobile network address, or is a proxy or non-proxy network address. A record is stored that maintains the association between the second attribute and the network address. | 01-15-2015 |
20150019738 | PROPAGATING ATTRIBUTES BETWEEN NETWORK ADDRESSES - In one embodiment, a technique is provided for propagating network address to attribute associations between network addresses. One or more profiles are obtained that maintain an association between a first network address and one or more attributes, the association produced from network address observations of the first network address by one or more source devices in communication with a network. A second network address is determined that is associated with the first network address based on a similarity criteria. The second network address initially lacks an association with the one or more attributes. The one or more attributes are propagated from the first network address to the second address, to form an association between the second network address and the one or more attributes. The association between the second network address and the one or more attributes is then stored in an updated profile. | 01-15-2015 |
20150019758 | PROCESSING MULTIPLE NETWORK ADDRESS OBSERVATIONS - In one embodiment, a processing technique is provided that utilizes multiple network address observations. One or more records are obtained that maintain network address observations, each network address observation associating one or more attributes with a network address observed by one or more source devices. Multiple network addresses from the network address observations are clustered into one or more discrete groups of network addresses based on a clustering criteria. For a selected group of network addresses, an association is formed associating one or more refined attributes derived from the selected group with an individual network address that is a member of the selected group. | 01-15-2015 |
20150020195 | ENSURING DATA QUALITY BY FILTERING NETWORK ADDRESS OBSERVATIONS - In one embodiment, a filtering technique is provided for ensuring data quality of network address observations. A network address observation is obtained of a network address associated with a source device, the network address observation associating the network address with one or more directly observed attributes. The network address observation is filtered based on a comparison of a selected one of the one or more directly observed attributes to a predetermined criteria, and using a result of the comparison as indicative of whether the network address observation should be used for association of the network address with one or more directly observed attributes. The filtering either associates one or more indicators with the network address observation, or removes the network address observation. A network address to attribute association system executed on one or more electronic devices stores a record that maintains any network address observation that has not been removed and any indicator. | 01-15-2015 |
Patent application number | Description | Published |
20080204268 | METHODS AND APPARATUS FOR CONVEYING INFORMATION VIA COLOR OF LIGHT - Methods and apparatus for conveying information. One or more information signals representing scalar or numeric information that is not associated with color is/are received from a data base, a network, the World Wide Web, or a software program. The information signal(s) is/are converted into one or more illumination control signals representing at least color information, and a color of illumination generated by one or more LED-based light sources is controlled in response to the illumination control signal(s) so as to convey the scalar or numeric information via at least the color of the generated illumination. | 08-28-2008 |
20090050908 | Solid state lighting component - An LED component according to the present invention comprising an array of LED chips mounted on a submount with the LED chips capable of emitting light in response to an electrical signal. The array can comprise LED chips emitting at two colors of light wherein the LED component emits light comprising the combination of the two colors of light. A single lens is included over the array of LED chips. The LED chip array can emit light of greater than 800 lumens with a drive current of less than 150 milli-Amps. The LED chip component can also operate at temperatures less than 3000 degrees K. In one embodiment, the LED array is in a substantially circular pattern on the submount. | 02-26-2009 |
20100127634 | METHODS AND APPARATUS FOR CONVEYING INFORMATION VIA COLOR OF LIGHT - Methods and apparatus for conveying information. One or more information signals representing scalar or numeric information that is not associated with color is/are received from a data base, a network, the World Wide Web, or a software program. The information signal(s) is/are converted into one or more illumination control signals representing at least color information, and a color of illumination generated by one or more LED-based light sources is controlled in response to the illumination control signal(s) so as to convey the scalar or numeric information via at least the color of the generated illumination. | 05-27-2010 |
20110151507 | Solar Biofactory, Photobioreactors, Passive Thermal Regulation Systems and Methods for Producing Products - The invention described herein relates to photobioreactors, methods, assembly and use of such apparatus for culturing light-capturing organisms in a cost-effective manner. Various embodiments provide for a passive thermal regulation system employing selected microorganisms in a photobioreactor apparatus and methods for biological production of various fuel and chemical products from these organisms. Additional embodiments provide a solar biofactory system capable of culturing light capturing organisms to an areal productivity of 3.3 g/m2/hr. Further embodiments are directed to a photobioreactor capable of culturing light capturing organisms to an OD | 06-23-2011 |
20120143357 | METHOD, APPARATUS, AND SYSTEM FOR OCCUPANCY SENSING - Embodiments of the present invention include an occupancy sensing unit configured to monitor an environment illuminated by a lighting fixture. An inventive occupancy sensing unit may include an occupancy sensor to detect radiation indicative of at least one occupancy event in the environment illuminated by the lighting fixture according to sensing parameters. The occupancy sensor can be coupled to a memory that logs sensor data, which represent the occupancy events, provided by the occupancy sensor. A processor coupled to the memory performs an analysis of the sensor data logged in the memory and adjusts the sensing parameters of the occupancy sensor based on the analysis. | 06-07-2012 |
20120235579 | METHODS, APPARATUS AND SYSTEMS FOR PROVIDING OCCUPANCY-BASED VARIABLE LIGHTING - A presence and an absence of an occupant is detected, and an occupancy sensor signal is generated representative of an active state in which the presence of the occupant is detected, and an inactive state in which the absence of the occupant is detected. An ambient light sensor detects the ambient light level and generates an ambient light sensor signal representative of the ambient light level. Dimmable illumination is generated at a first dimming level, based on the ambient light level, corresponding to the active state and a second dimming level corresponding to the inactive state. A transition delay time between an onset of the inactive state and a transition between the first dimming level and the second dimming level may be controlled. The first dimming level, the second dimming level, and/or the transition delay time may be variably set or controlled locally or via a remote device. | 09-20-2012 |
20120310703 | TARGETED CONTENT DELIVERY USING OUTDOOR LIGHTING NETWORKS (OLNs) - This invention describes a system and method to provide a service to advertisers and businesses that enables adaptation of advertising priorities using information collected by a lighting infrastructure. The system uses outdoor lighting networks to manage/control data sensors connected to a network, e.g. hosted at lighting units. This invention enables new business scenarios where operators and/or owners of the city's lighting infrastructure can provide a value added service or generate revenue from ad providers and local businesses by leveraging the data acquired through the lighting and adjacent infrastructure (e.g. sensors) to help the businesses to increase their advertising performance/targets; particularly, with respect to Location Based Services (LBS). | 12-06-2012 |
20130224853 | Solar Biofactory, Photobioreactors, Passive Thermal Regulation Systems And Methods for Producing Products - The invention described herein relates to photobioreactors, methods, assembly and use of such apparatus for culturing light-capturing organisms in a cost-effective manner. Various embodiments provide for a passive thermal regulation system employing selected microorganisms in a photobioreactor apparatus and methods for biological production of various fuel and chemical products from these organisms. Additional embodiments provide a solar biofactory system capable of culturing light capturing organisms to an areal productivity of 3.3 g/m2/hr. Further embodiments are directed to a photobioreactor capable of culturing light capturing organisms to an OD | 08-29-2013 |
20140192527 | INTEGRATED LED-BASED LUMINAIRE FOR GENERAL LIGHTING - Lighting apparatus and methods employing LED light sources are described. The LED light sources are integrated with other components in the form of a luminaire or other general purpose lighting structure. Some of the lighting structures are formed as Parabolic Aluminum Reflector (PAR) luminaires, allowing them to be inserted into conventional sockets. The lighting structures display beneficial operating characteristics, such as efficient operation, high thermal dissipation, high output, and good color mixing. | 07-10-2014 |
20140195639 | System, Method, and Apparatus for Communicating Data - A system includes first and second hubs. The first hub is configured to communicate data with a medical device through a Local Area Network and package the data into at least one application-layer packet. The second hub is configured to receive the at least one application-layer packet from the first hub operatively through at least one cellular network. | 07-10-2014 |
20150184842 | METHOD, APPARATUS, AND SYSTEM FOR OCCUPANCY SENSING - Embodiments of the present invention include an occupancy sensing unit configured to monitor an environment illuminated by a lighting fixture. An inventive occupancy sensing unit may include an occupancy sensor to detect radiation indicative of at least one occupancy event in the environment illuminated by the lighting fixture according to sensing parameters. The occupancy sensor can be coupled to a memory that logs sensor data, which represent the occupancy events, provided by the occupancy sensor. A processor coupled to the memory performs an analysis of the sensor data logged in the memory and adjusts the sensing parameters of the occupancy sensor based on the analysis. | 07-02-2015 |
20150257974 | Compounder Apparatus - A containment assembly for enclosing a medication vial may comprise a first housing portion or interface portion having a proximal end and a distal end. The interface portion may include a housing wall which defines a channel spanning from the proximal end to the distal end. The channel may be open at the proximal and distal end. The containment assembly may further comprise at least one pierceable septum disposed at least at one of: on the proximal end of the channel and within the channel forming a barrier between the proximal end of the channel and distal end of the channel of the interface portion. The containment assembly may further comprise a variable-volume housing portion having a variable volume chamber. The variable-volume portion chamber of the variable-volume housing portion may be in fluid communication with the distal end of the channel. | 09-17-2015 |
Patent application number | Description | Published |
20100207534 | INTEGRATED LED-BASED LUMINARE FOR GENERAL LIGHTING - Lighting apparatus and methods employing LED light sources are described. The LED light sources are integrated with other components in the form of a luminaire or other general purpose lighting structure. Some of the lighting structures are formed as Parabolic Aluminum Reflector (PAR) luminaires, allowing them to be inserted into conventional sockets. The lighting structures display beneficial operating characteristics, such as efficient operation, high thermal dissipation, high output, and good color mixing. | 08-19-2010 |
20110217692 | Photobioreactors, Solar Energy Gathering Systems, And Thermal Control Methods - The present invention provides photobioreactors, solar energy gathering systems, and methods for thermal control of a culture medium containing a prototrophic organism in a photobioreactor, that allow temperature control in a cost effective manner, reducing the energy required for temperature control of a culture medium containing phototrophic microorganisms in a photobioreactor. | 09-08-2011 |
20130244320 | Photobioreactors, Solar Energy Gathering Systems, and Thermal Control Methods - The present invention provides photobioreactors, solar energy gathering systems, and methods for thermal control of a culture medium containing a phototrophic organism in a photobioreactor, that allow temperature control in a cost effective manner, reducing the energy required for temperature control of a culture medium containing phototrophic microorganisms in a photobioreactor. | 09-19-2013 |
20140292208 | METHODS, SYSTEMS, AND APPARATUS FOR INTELLIGENT LIGHTING - An ambient light sensor measures an ambient light level at one point in an illuminated environment, such as a warehouse, office, shop, cold-storage facility, or industrial facility, and provides an indication of the measured ambient light level to a processor. The processor maps the measured ambient light level to an estimated ambient light level at a different point in the illuminated environment from the measured ambient light level (e.g., a “task height” about three feet from a warehouse floor). The processor may determine the difference between the estimated ambient light level and a desired light level at the task height, and may change the artificial illumination provided by a light fixture to make the actual ambient light level at task height match the desired light level at the task height. | 10-02-2014 |
20140329223 | Photobioreactors, Solar Energy Gathering Systems, And Thermal Control Methods - The present invention provides photobioreactors, solar energy gathering systems, and methods for thermal control of a culture medium containing a phototrophic organism in a photobioreactor, that allow temperature control in a cost effective manner, reducing the energy required for temperature control of a culture medium containing phototrophic microorganisms in a photobioreactor. | 11-06-2014 |
20140333222 | METHODS, SYSTEMS, AND APPARATUS FOR PROVIDING VARIABLE ILLUMINATION - Digital Control Ready (DCR) is a two-way open standard for controlling and managing next-generation fixtures. A DCR-enabled lighting fixture responds to digital control signals from a separate digital light agent (DLA) instead of analog dimming signals, eliminating the need for digital-to-analog signal conditioning, fixture-to-fixture variations in response, and calibration specific to each fixture. In addition, a DCR-enabled lighting fixture may also report its power consumption, measured light output, measured color temperature, temperature, and/or other operating parameters to the DLA via the same bidirectional data link that carries the digital control signals to the fixture. The DLA processes these signals in a feedback loop to implement more precise lighting control. The DCR-enabled lighting fixture also transforms AC power to DC power and supplies (and measures) DC power to the DLA via a DCR interface. These features enable intelligent, networked DCR lighting systems operate with lower power (energy) consumption, greater flexibility, and simpler installation than other intelligent lighting networks. | 11-13-2014 |
Patent application number | Description | Published |
20080215391 | UNIVERSAL LIGHTING NETWORK METHODS AND SYSTEMS - Methods and apparatus relating to the collection of data regarding a plurality of customers in a retail or entertainment environment. Data may be collected via at least one sensor coupled to at least one lighting fixture in the retail or entertainment environment. In one exemplary implementation, data may be collected by one or more lighting fixtures, and data may be communicated via light generated by any one or more fixtures without perceivably affecting a quality of light generated by the one or more fixtures. A map may be generated based on the collected data to display traffic patterns and/or dwell times of the plurality of customers in the retail or entertainment environment, and such a map may be displayed, for example, via a graphical user interface. | 09-04-2008 |
20100148689 | SYSTEMS AND METHODS FOR CALIBRATING LIGHT OUTPUT BY LIGHT-EMITTING DIODES - A system and method for calibrating light output from an LED is provided. The system includes a support on which an LED is positioned, a photosensor to measure the light output from the LED, and means for calibrating and adjusting the light output of the LED. Calibration is accomplished by measuring the light output from the LED, comparing such output against a reference value, and adjusting the measured output against the reference value. | 06-17-2010 |
20100171145 | LED PACKAGE METHODS AND SYSTEMS - Methods and systems are provided for LED modules that include an LED die integrated in an LED package with a submount that includes an electronic component for controlling the light emitted by the LED die. The electronic component integrated in the s submount may include drive hardware, a network interface, memory, a processor, a switch-mode power supply, a power facility, or another type of electronic component. | 07-08-2010 |
Patent application number | Description | Published |
20090104095 | NOVEL COMPOSITIONS AND RELATED METHODS, COATINGS, AND ARTICLES - Novel compositions, as well as related methods, coatings, and articles, are disclosed. | 04-23-2009 |
20090104473 | NOVEL COMPOSITIONS AND RELATED METHODS, COATINGS, AND ARTICLES - Novel compositions, as well as related methods, coatings, and articles, are disclosed. | 04-23-2009 |
20090105384 | NOVEL COMPOSITIONS AND RELATED METHODS, COATINGS, AND ARTICLES - Novel compositions, as well as related methods, coatings, and articles, are disclosed. | 04-23-2009 |
20110212481 | ASSAYS AND METHODS FOR FUSING CELL AGGREGATES TO FORM PROTO-TISSUES - Provided are assays and methods for creating proto-tissues from aggregates of cells. The invention concerns assays and methods useful in tissue engineering and reconstruction techniques, specifically in the formation of macrotissues from microtissues using microtissue pre-culture time as a controlling parameter. | 09-01-2011 |
20130079288 | DIFFERENTIAL EFFECTS OF DRUGS ON TRANSPORT IN A MULTI-LAYER 3D SPHEROID MODEL - Drugs are screened for affects on inhibiting efflux pumps and blocking gap junction communication in tumors by culturing cells to thereby form self-assembled spheroids and incubating the spheroids. Uptake of a substrate of the efflux pump and distribution of a substrate for the efflux pump within the spheroids is imaged to thereby select drugs that inhibit the efflux pump or do not block gap junction communication. Selected drugs can then be employed to treat a tumor. | 03-28-2013 |
20130109625 | MECHANOTRANSDUCTION BY THE SYNERGISTIC ACTION OF HETEROTYPIC CELL INTERACTIONS | 05-02-2013 |
Patent application number | Description | Published |
20150178199 | METHOD AND APPARATUS FOR SHARED LINE UNIFIED CACHE - An apparatus and method for implementing a shared unified cache. For example, one embodiment of a processor comprises: a plurality of processor cores grouped into modules, wherein each module has at least two processor cores grouped therein; a plurality of level 1 (L1) caches, each L1 cache directly accessible by one of the processor cores; a level 2 (L2) cache associated with each module, the L2 cache directly accessible by each of the processor cores associated with its respective module; a shared unified cache to store data and/or instructions for each of the processor cores in each of the modules; and a cache management module to manage the cache lines in the shared unified cache using a first cache line eviction policy favoring cache lines which are shared across two or more modules and which are accessed relatively more frequently from the modules. | 06-25-2015 |
20150186319 | COMPUTER ARCHITECTURE TO PROVIDE FLEXIBILITY AND/OR SCALABILITY - Apparatus, systems, and/or methods may include a peripheral component interconnect express (PCIe) link to directly couple a slot with a network fabric. The slot may be defined by a surface and/or may accommodate a hardware module. A rack unit implementation may be utilized, such as a one rack unit (1 U) implementation, a four rack unit (4 U) implementation, and so on. The network fabric may be utilized when hardware modules communicate across the PCIe link, may be bypassed when hardware modules communicate across an additional PCIe link, and so on. The PCIe link may include a direct connect point-to-point PCIe link, a dual star PCIe link, and so on. In addition, the PCIe link may be utilized in a rack-scale architecture. | 07-02-2015 |
Patent application number | Description | Published |
20100310846 | CEMENTITIOUS FOAMS AND FOAM SLURRIES - Lightweight cementitious foams of the invention have excellent dynamic and dimensional stability due to use of foaming system comprising polycarboxylate surfactant foam generating agent, foam stabilizer (e.g., PVOH), and shrinkage reducing admixture to inhibit plastic shrinkage and micro-cracking of cement. The foaming system can be used in conventional cement mortars or concretes as well as with exemplary cementitious slurry systems of the invention, which include an expansive agent, a cross-linking agent for the foam stabilizer. Microfibers can be used in the foam, slurry, or both, to prevent micro-cracking. Cementitious foams can be made without use of autoclave or lightweight aggregates to achieve enhanced compressive strength and thermal insulation properties that compare favorably with conventional foams and insulation materials at comparable densities. | 12-09-2010 |
20120322902 | CEMENTITIOUS FOAM COMPOSITIONS - Lightweight cementitious foams of the invention have excellent dynamic and dimensional stability due to use of foaming system comprising polycarboxylate surfactant foam generating agent, foam stabilizer (e.g., PVOH), and shrinkage reducing admixture to inhibit plastic shrinkage and micro-cracking of cement. The foaming system can be used in conventional cement mortars or concretes as well as with exemplary cementitious slurry systems of the invention, which include an expansive agent, a cross-linking agent for the foam stabilizer. Microfibers can be used in the foam, slurry, or both, to prevent micro-cracking. Cementitious foams can be made without use of autoclave or lightweight aggregates to achieve enhanced compressive strength and thermal insulation properties that compare favorably with conventional foams and insulation materials at comparable densities. | 12-20-2012 |
Patent application number | Description | Published |
20100287313 | APPLICATION VIRTUALIZATION - A virtual application packaged for a specific executing environment may be executed on a processing device having an executing environment different from the specific executing environment. A reference, included in extracted installer metadata, to one or more key paths of a hierarchically-structured data store may be modified according to a set of rules related to the executing environment detected in the processing device. The modified extracted installer metadata may be provided to an installer for installing the virtual application. During execution of the virtual application, a request to read, write, or modify the hierarchically-structured data store may be intercepted and changed, such that a first key path included in the request may be mapped to a second key path, based on the detected executing environment. Similarly, a response to the request, which may include the second key path, may be intercepted and modified, to the first key path. | 11-11-2010 |
20130227545 | APPLICATION VIRTUALIZATION - A virtual application packaged for a specific executing environment may be executed on a processing device having an executing environment different from the specific executing environment. A reference, included in extracted installer metadata, to one or more key paths of a hierarchically-structured data store may be modified according to a set of rules related to the executing environment detected in the processing device. The modified extracted installer metadata may be provided to an installer for installing the virtual application. During execution of the virtual application, a request to read, write, or modify the hierarchically-structured data store may be intercepted and changed, such that a first key path included in the request may be mapped to a second key path, based on the detected executing environment. Similarly, a response to the request, which may include the second key path, may be intercepted and modified, to the first key path. | 08-29-2013 |
20130227546 | APPLICATION VIRTUALIZATION - A virtual application packaged for a specific executing environment may be executed on a processing device having an executing environment different from the specific executing environment. A reference, included in extracted installer metadata, to one or more key paths of a hierarchically-structured data store may be modified according to a set of rules related to the executing environment detected in the processing device. The modified extracted installer metadata may be provided to an installer for installing the virtual application. During execution of the virtual application, a request to read, write, or modify the hierarchically-structured data store may be intercepted and changed, such that a first key path included in the request may be mapped to a second key path, based on the detected executing environment. Similarly, a response to the request, which may include the second key path, may be intercepted and modified, to the first key path. | 08-29-2013 |
Patent application number | Description | Published |
20090036320 | Rational Design of Binding Proteins That Recognize Desired Specific Sequences - Methods and compositions are provided for creating a binding protein that recognizes a rationally chosen recognition sequence in which a first amino acid has been substituted for a second amino acid using site-directed mutagenesis of a member protein of a set of proteins at an identified position or positions correlated with recognition of a chosen specified target module in the recognition sequence. A system is provided for automating the storage and manipulation of the correlations between positions and types of amino acid residues in the binding protein with specific modules at specified positions in the target recognition sequence and for designing and creating proteins with novel specificities. | 02-05-2009 |
20100159534 | Recombinant Type II Restriction Endonuclease, NmeAIII, and a Process for Producing the Same - A protein is described that has an amino acid sequence characterized by at least 90% sequence identity with SEQ ID NO: 24, the protein being capable of recognizing a sequence consisting of 5′-GCCGAG-3′ within the double-stranded DNA and cleaving the substrate predominantly at 21/19 nucleotides from the recognition site. A method is also described that utilizes the protein for creating a DNA tag for use as a unique identifier for paired end sequencing of DNA or serial analysis of gene expression. | 06-24-2010 |
20100304462 | Synthetic Binding Proteins - Methods and compositions are provided for creating a binding protein that recognizes a rationally chosen recognition sequence in which a first amino acid has been substituted for a second amino acid using site-directed mutagenesis of a member protein of a set of proteins at an identified position or positions correlated with recognition of a chosen specified target module in the recognition sequence. A system is provided for automating the storage and manipulation of the correlations between positions and types of amino acid residues in the binding protein with specific modules at specified positions in the target recognition sequence and for designing and creating proteins with novel specificities. | 12-02-2010 |
20100330551 | Novel Restriction Endonucleases, DNA Encoding These Endonucleases and Methods for Identifying New Endonucleases with the Same or Varied Specificity - Specified restriction endonucleases have been characterized for the first time by their amino acid and DNA sequences. These sequences and those with at least 90% identity thereto have been used as probes in sequence similarity analyses to identify sequence matches in a sequence database that corresponds to novel restriction endonucleases or isoschizomers. The sequence similarity analyses includes selecting a positive sequence match from any sequence producing an expectation value of less than or equal to e-02. | 12-30-2010 |
20120254213 | Novel Restriction Endonucleases, DNA Encoding These Endonucleases and Methods for Identifying New Endonucleases with the Same or Varied Specificity - Specified restriction endonucleases have been characterized for the first time by their amino acid and DNA sequences. These sequences and those with at least 90% identity thereto have been used as probes in sequence similarity analyses to identify sequence matches in a sequence database that corresponds to novel restriction endonucleases or isoschizomers. The sequence similarity analyses includes selecting a positive sequence match from any sequence producing an expectation value of less than or equal to e−02. | 10-04-2012 |
20130029401 | Synthetic Binding Proteins - Methods and compositions are provided for creating a binding protein that recognizes a rationally chosen recognition sequence in which a first amino acid has been substituted for a second amino acid using site-directed mutagenesis of a member protein of a set of proteins at an identified position or positions correlated with recognition of a chosen specified target module in the recognition sequence. A system is provided for automating the storage and manipulation of the correlations between positions and types of amino acid residues in the binding protein with specific modules at specified positions in the target recognition sequence and for designing and creating proteins with novel specificities. | 01-31-2013 |
20130224832 | Novel Restriction Endonucleases, DNA Encoding These Endonucleases and Methods for Identifying New Endonucleases with the Same or Varied Specificity - Specified restriction endonucleases have been characterized for the first time by their amino acid and DNA sequences. These sequences and those with at least 90% identity thereto have been used as probes in sequence similarity analyses to identify sequence matches in a sequence database that corresponds to novel restriction endonucleases or isoschizomers. The sequence similarity analyses includes selecting a positive sequence match from any sequence producing an expectation value of less than or equal to e−02. | 08-29-2013 |
20130244304 | Novel Restriction Endonucleases, DNA Encoding These Endonucleases and Methods for Identifying New Endonucleases with the Same or Varied Specificity - Specified restriction endonucleases have been characterized for the first time by their amino acid and DNA sequences. These sequences and those with at least 90% identity thereto have been used as probes in sequence similarity analyses to identify sequence matches in a sequence database that corresponds to novel restriction endonucleases or isoschizomers. The sequence similarity analyses includes selecting a positive sequence match from any sequence producing an expectation value of less than or equal to e-02. | 09-19-2013 |
Patent application number | Description | Published |
20100247436 | In vivo photodynamic therapy of cancer via a near infrared agent encapsulated in calcium phosphate nanoparticles - Nano-encapsulated photosensitizers and their use in the treatment of tumors and/or imaging is described. Preferably, the photosensitizers are encapsulated in a calcium phosphate nanoparticle (CPNP). Encapsulating the PS in a CPNP increases the half-life of the PS, increases absorption of the PS into the target cell tissue, increases the photostability of the PS, increases the photoefficiency of the PS, increases in vivo retention of the PS, or combinations thereof, ultimately making it a highly efficacious agent for use in photodynamic therapy, imaging target tissues, vessels, or tumors, and/or detecting or locating tumors. | 09-30-2010 |
20110129413 | Bioconjugation of Calcium Phosphosilicate Nanoparticles For Selective Targeting of Cells In Vivo - Non-aggregating resorbable calcium phosphosilicate nanoparticles (CPNPs) are bioconjugated to targeting molecules that are specific for particular cells. The CPNPs are stable particles at normal physiological pH. Chemotherapy and imaging agents may be integrally formed with the CPNPs so that they are compartmentalized within the CPNPs. In this manner, the agents are protected from interaction with the environment at normal physiological pH. However, once the CPNPs have been taken up, at intracellular pH, the CPNPs dissolve releasing the agent. Thus, chemotherapeutic or imaging agents are delivered to specific cells and permit the treatment and/or imaging of those cells. Use of the bioconjugated CPNPs both limits the amount of systemic exposure to the agent and delivers a higher concentration of the agent to the cell. The methods and principals of bioconjugating CPNPs are taught by examples of bioconjugation of targeting molecules for breast cancer, pancreatic cancer, and leukemia. | 06-02-2011 |
20140154325 | IN VIVO PHOTODYNAMIC THERAPY OF CANCER VIA A NEAR INFRARED AGENT ENCAPSULATED IN CALCIUM PHOSPHATE NANOPARTICLES - Nano-encapsulated photosensitizers and their use in the treatment of tumors and/or imaging is described. Preferably, the photosensitizers are encapsulated in a calcium phosphate nanoparticle (CPNP). Encapsulating the PS in a CPNP increases the half-life of the PS, increases absorption of the PS into the target cell tissue, increases the photostability of the PS, increases the photoefficiency of the PS, increases in vivo retention of the PS, or combinations thereof, ultimately making it a highly efficacious agent for use in photodynamic therapy, imaging target tissues, vessels, or tumors, and/or detecting or locating tumors. | 06-05-2014 |