Patent application number | Description | Published |
20090074723 | Method of Treating or Retarding the Development of Blindness - A method for treating an ocular disorder characterized by the defect or absence of a normal gene in the ocular cells of a human or animal subject involves administering to the subject by subretinal injection an effective amount of a recombinant adeno-associated virus carrying a nucleic acid sequence encoding the normal gene under the control of a promoter sequence which expresses the product of the gene in the ocular cells. The ocular cells are preferably retinal pigment epithelial (RPE) cells, and the gene is preferably an RPE-specific gene, e.g., RPE65. The promoter is one that can express the gene product in the RPE cells. Compositions for subretinal administration are useful in this method. | 03-19-2009 |
20100272688 | METHOD OF TREATING OR RETARDING THE DEVELOPMENT OF BLINDNESS - A method for treating an ocular disorder characterized by the defect or absence of a normal gene in the ocular cells of a human or animal subject involves administering to the subject by subretinal injection an effective amount of a recombinant adeno-associated virus carrying a nucleic acid sequence encoding the normal gene under the control of a promoter sequence which expresses the product of the gene in the ocular cells. The ocular cells are preferably retinal pigment epithelial (RPE) cells, and the gene is preferably an RPE-specific gene, e.g., RPE65. The promoter is one that can express the gene product in the RPE cells. Compositions for subretinal administration are useful in this method. | 10-28-2010 |
20120225930 | METHOD OF TREATING OR RETARDING THE DEVELOPMENT OF BLINDNESS - A method for treating an ocular disorder characterized by the defect or absence of a normal gene in the ocular cells of a human or animal subject involves administering to the subject by subretinal injection an effective amount of a recombinant adeno-associated virus carrying a nucleic acid sequence encoding the normal gene under the control of a promoter sequence which expresses the product of the gene in the ocular cells. The ocular cells are preferably retinal pigment epithelial (RPE) cells, and the gene is preferably an RPE-specific gene, e.g., RPE65. The promoter is one that can express the gene product in the RPE cells. Compositions for subretinal administration are useful in this method. | 09-06-2012 |
20130216500 | METHOD OF TREATING OR RETARDING THE DEVELOPMENT OF BLINDNESS - A method for treating an ocular disorder characterized by the defect or absence of a normal gene in the ocular cells of a human or animal subject involves administering to the subject by subretinal injection an effective amount of a recombinant adeno-associated virus carrying a nucleic acid sequence encoding the normal gene under the control of a promoter sequence which expresses the product of the gene in the ocular cells. The ocular cells are preferably retinal pigment epithelial (RPE) cells, and the gene is preferably an RPE-specific gene, e.g., RPE65. The promoter is one that can express the gene product in the RPE cells. Compositions for subretinal administration are useful in this method. | 08-22-2013 |
20140377224 | Method of Treating or Retarding the Development of Blindness - A method for treating an ocular disorder characterized by the defect or absence of a normal gene in the ocular cells of a human or animal subject involves administering to the subject by subretinal injection an effective amount of a recombinant adeno-associated virus carrying a nucleic acid sequence encoding the normal gene under the control of a promoter sequence which expresses the product of the gene in the ocular cells. The ocular cells are preferably retinal pigment epithelial (RPE) cells, and the gene is preferably an RPE-specific gene, e.g., RPE65. The promoter is one that can express the gene product in the RPE cells. Compositions for subretinal administration are useful in this method. | 12-25-2014 |
Patent application number | Description | Published |
20090269784 | PROTEIN ENGINEERING OF MONOACYLGLYCEROL LIPASE (MGLL) - A number of soluble engineered forms of MGLL that are suitable for high-throughput screening and protein crystallization, as well as a crystallized form of monoacylglycerol lipase protein (MGLL) and descriptions of the X-ray diffraction patterns are disclosed. The engineered constructs of MGLL permit the expression and purification of protein suitable for crystallography or high-throughput screening and identification of ligands, which can function as active agents to MGLL. The X-ray diffraction patterns allow the three dimensional structure of MGLL to be determined at atomic resolution so that ligand binding sites on MGLL can be identified and the interactions of ligands with MGLL amino acid residues can be modeled. Models prepared using such maps permit the design of ligands which can function as active agents which include, but are not limited to, those that function as inhibitors of MGLL. | 10-29-2009 |
20090269785 | CRYSTAL STRUCTURE OF MONOACYLGLYCEROL LIPASE (MGLL) - A number of soluble engineered forms of MGLL that are suitable for high-throughput screening and protein crystallization, as well as a crystallized form of monoacylglycerol lipase protein (MGLL) and descriptions of the X-ray diffraction patterns are disclosed. The engineered constructs of MGLL permit the expression and purification of protein suitable for crystallography or high-throughput screening and identification of ligands, which can function as active agents to MGLL. The X-ray diffraction patterns allow the three dimensional structure of MGLL to be determined at atomic resolution so that ligand binding sites on MGLL can be identified and the interactions of ligands with MGLL amino acid residues can be modeled. Models prepared using such maps permit the design of ligands which can function as active agents which include, but are not limited to, those that function as inhibitors of MGLL. | 10-29-2009 |
20100093009 | ALTERNATIVE CRYSTAL FORM OF MONOACYLGLYCEROL LIPASE (MGLL) - A number of soluble engineered forms of MGLL that are suitable for high-throughput screening and protein crystallization, as well as a crystallized forms of monoacylglycerol lipase protein (MGLL) and descriptions of the X-ray diffraction patterns are disclosed. The engineered constructs of MGLL permit the expression and purification of protein suitable for crystallography or high-throughput screening and identification of ligands, which can function as active agents to MGLL. The X-ray diffraction patterns allow the three dimensional structure of MGLL to be determined at atomic resolution so that ligand binding sites on MGLL can be identified and the interactions of ligands with MGLL amino acid residues can be modeled. Models prepared using such maps permit the design of ligands which can function as active agents which include, but are not limited to, those that function as inhibitors of MGLL. | 04-15-2010 |
20130040360 | Crystal Structure of the Pro Form of a Matrix Metalloproteinase and an Allosteric Processing Inhibitor - The present invention includes a crystal comprising a complex of the pro form of a matrix metalloprotease (proMMP) and a small-molecule allosteric processing inhibitor that inhibits that activation of the proMMP, methods for identifying small-molecule allosteric processing inhibitors that inhibit the activation of a proMMP, and methods of treatment using small-molecule allosteric processing inhibitors that inhibit the activation of a proMMP. The present invention relates to the crystal structure of a complex of proMMP9 bound to a small-molecule allosteric processing inhibitor that inhibits activation of proMMP9. The invention further relates to the use of the methods and the crystal and related structural information for designing, selecting and/or optimizing small-molecule allosteric processing inhibitors that inhibit activation of proMMP9 and proMMP9 homologues. The present invention also relates to the use of small-molecule allosteric processing inhibitors for the treatment of diseases mediated by inappropriate matrix metalloproteinase (MMP) activity. | 02-14-2013 |
20130040994 | Methods of Treatment Using Allosteric Processing Inhibitors for Matrix Metalloproteinases - The present invention includes a crystal comprising a complex of the pro form of a matrix metalloprotease (proMMP) and a small-molecule allosteric processing inhibitor that inhibits that activation of the proMMP, methods for identifying small-molecule allosteric processing inhibitors that inhibit the activation of a proMMP, and methods of treatment using small-molecule allosteric processing inhibitors that inhibit the activation of a proMMP. The present invention relates to the crystal structure of a complex of proMMP9 bound to a small-molecule allosteric processing inhibitor that inhibits activation of proMMP9. The invention further relates to the use of the methods and the crystal and related structural information for designing, selecting and/or optimizing small-molecule allosteric processing inhibitors that inhibit activation of proMMP9 and proMMP9 homologues. The present invention also relates to the use of small-molecule allosteric processing inhibitors for the treatment of diseases mediated by inappropriate matrix metalloproteinase (MMP) activity. | 02-14-2013 |
20130166268 | Crystal Structure of the Pro Form of a Matrix Metalloproteinase and an Allosteric Processing Inhibitor - The present invention includes a crystal comprising a complex of the pro form of a matrix metalloprotease (proMMP) and a small-molecule allosteric processing inhibitor that inhibits that activation of the proMMP, methods for identifying small-molecule allosteric processing inhibitors that inhibit the activation of a proMMP, and methods of treatment using small-molecule allosteric processing inhibitors that inhibit the activation of a proMMP. The present invention relates to the crystal structure of a complex of proMMP9 bound to a small-molecule allosteric processing inhibitor that inhibits activation of proMMP9. The invention further relates to the use of the methods and the crystal and related structural information for designing, selecting and/or optimizing small-molecule allosteric processing inhibitors that inhibit activation of proMMP9 and proMMP9 homologues. The present invention also relates to the use of small-molecule allosteric processing inhibitors for the treatment of diseases mediated by inappropriate matrix metalloproteinase (MMP) activity. | 06-27-2013 |
Patent application number | Description | Published |
20090126564 | DIAPHRAGM ACTUATED BLOW-BACK VALVE AND RESERVOIR - An accumulator having an internal valve opened by applying air pressure to a diaphragm with a small solenoid to apply air to the diaphragm where the air is supplied from a pilot air supply. When the internal valve operated by the diaphragm opens, it snaps to a fully open position thereby opening the valve and uncovering a passageway leading to a filter for cleaning. The passageway is sufficiently wide that the resulting flow of air through the passageway is so explosive that air pressure on the filter is distributed over the surface area of the filter for a brief moment, blowing the dust on the filter free. | 05-21-2009 |
20090257832 | VACUUM DRIVEN BULK RESIN UNLOADING APPARATUS AND METHOD - The present invention relates to a vacuum loader assembly wherein the assembly is comprised of a frame, a first and second tube, a flexible tube, a motor, and a sweeper assembly. The frame is adapted to be positioned over an opening of the container. The first tube is mounted to the frame and is in fluid communication with a vacuum source. The second tube is rotatably mounted to the first tube and is also in fluid communication with the first tube and the sweeper assembly is mounted to the second tube. The flexible tube extends from the second tube such that, when the frame of the present invention is placed over a container, the second tube, flexible tube, and sweeper assembly are lowered into the container and rotated by the motor such that, when the vacuum source is activated, the flexible tube suctions out the contents of the container. | 10-15-2009 |
20100170659 | MOLDING APPARATUS AND METHOD WITH HEAT RECOVERY - Apparatus and method for recapturing and reusing heat provided in the course of fabricating a molded product. | 07-08-2010 |
20120260992 | APPARATUS AND METHODS FOR GRAVIMETRICALLY METERING LIQUID COLOR - Apparatus and methods for delivering liquid color to a plastic resin processing machine include a scale for weighing a container of liquid color, a pump for removing liquid color from the container, controller for actuating pushers in the pump in a sequence whereby a first pusher is displaced to squeeze the delivery tube while a second and third pusher are not displaced thereby permitting liquid color to flow through the tube from the supply to a first position of tube squeezing, whereupon a second pusher is displaced to squeeze the tube and substantially trapped liquid color in the tube at the first and second position of tube squeezing, whereupon the first pusher permits liquid color to flow through the tube pass the first position of tube squeezing and the third pusher squeezes the tube and thereby forces at least a portion of the trapped liquid color material through the tube pass the first position of tube squeezing thereby supplying liquid color to the plastic resin processing machine at a predetermined rate according to a selected recipe to produce plastic parts having desired characteristics. | 10-18-2012 |
Patent application number | Description | Published |
20120160866 | TILTABLE VACUUM LOADER AND RECEIVER WITH BLOW-BACK - A vacuum loader for providing granular resin material to resin material processing equipment has a loader housing, a vacuum motor, a dust filter, an air blast generator, a dump flap, and a pivoting manually releasable latch for retaining the lateral web and the loader from tilting rotation of the loader about the shaft and supporting the loader when placed in a tilted orientation; the latch being weighted to pivotally return to a web-retaining position when released by an operator. | 06-28-2012 |
20120269587 | CONTAINER EMPTYING APPARATUS AND METHOD - This invention relates to a container emptying apparatus including a frame, a first and second tube, a suction tube, a motor, and a sweeper. The frame is adapted to be positioned over an opening of the container. The first tube is mounted on the frame and is in fluid communication with a vacuum source. The second tube is rotatably connected to the first tube and is also in fluid communication with the first tube. The sweeper assembly is connected to the second tube. The suction tube extends from the second tube such that, when the frame of this invention is placed over a container, the second tube, the suction flexible tube, and the associated sweeper assembly are lowered into the container and rotated by the motor such that, when the vacuum source is activated, the suction tube suctions the contents from the container. | 10-25-2012 |
20130334258 | INJECTION MOLDED DIAPHRAGM PUMP FOR LIQUID COLOR WITH QUICK RELEASE - A pneumatically powered pump for liquid color adapted to fit partially within a liquid color container having a body portion of the pump within the liquid color container adapted to be mounted on the underside of the container lid and being a single piece of molded plastic overlying an aperture in the container lid. | 12-19-2013 |
20140138055 | MOLDING APPARATUS AND METHOD WITH HEAT RECOVERY - Apparatus and method for recapturing and reusing heat provided in the course of fabricating a molded product. | 05-22-2014 |
20140147288 | PUMP ACTUATOR AND METHOD FOR PUMP OPERATION - Method and apparatus for controlling a moveable pumping diaphragm and a liquid color diaphragm pump, including a housing, a movable pin slidably residing within the housing, a potentiometer connected to and residing within the housing for sensing movement of the pin, riding against the diaphragm of the pump and a spring for biasing the pin against the diaphragm. | 05-29-2014 |
20140201944 | TILTABLE VACUUM LOADER - A vacuum loader for providing granular resin material to resin material processing equipment has a loader housing, a vacuum motor, a dust filter, an air blast generator, a dump flap, and a pivoting manually releasable latch for retaining the lateral web and the loader from tilting rotation of the loader about the shaft and supporting the loader when placed in a tilted orientation; the latch being weighted to pivotally return to a web-retaining position when released by an operator. | 07-24-2014 |
20140205386 | VACUUM LOADING METHOD - A vacuum loader for providing granular resin material to resin material processing equipment has a loader housing, a vacuum motor, a dust filter, an air blast generator, a dump flap, and a pivoting manually releasable latch for retaining the lateral web and the loader from tilting rotation of the loader about the shaft and supporting the loader when placed in a tilted orientation; the latch being weighted to pivotally return to a web-retaining position when released by an operator. | 07-24-2014 |
20140239533 | SIMULTANEOUS RESIN DRYING AND MOLDING - A low pressure dryer for granular or powdery material includes a plurality of canisters rotatable about a common vertical axis serially among material heating, vacuum drying and material inventory discharge positions; pneumatic piston-cylinder means for rotating the canisters about said axis among said heating, vacuum drying and inventory discharge positions; means for heating contents of a canister at said heating position; means for sealing and drawing vacuum within a canister at said vacuum drying position and means for selectably permitting downward flow of dried granular or powdery material out of a canister at said discharge position where said canisters move collectively and unitarily one with another. | 08-28-2014 |
20150020713 | LIQUID COLOR COMPOSITION WITH COTTONSEED OIL BASE - A liquid colorant for use in molding or extruding plastic products comprises pigment dispersed in cottonseed oil. | 01-22-2015 |
20150108748 | MULTIPLE PLATE QUICK DISCONNECT SANDWICH FITTING - A fitting allowing a quick connection and disconnection of liquid color conduits includes a quick disconnect plate assembly having three plates layered on top of each other, the top plate including guides sized to receive projections extending off structure to which the fitting is to be connected, with the middle plate including stops engaging with the same projections upon rotation of the structure. | 04-23-2015 |