Patent application number | Description | Published |
20090187038 | REAGENTS AND METHODS FOR THE BETA-KETO AMIDE SYNTHESIS OF A SYNTHETIC PRECURSOR TO IMMUNOLOGICAL ADJUVANT E6020 - This invention relates to the synthesis for a precursor of E6020, compound 26, via a β-keto amide alcohol intermediate, compound 22. The synthesis reacts compound 22 with compound 25 and the resultant intermediate is oxidized to produce compound 26, the precursor to E6020. Compounds 22 and 25, and their crystalline forms, represent separate embodiments of the invention. The invention also relates to compounds of formulas (3) and (4) and processes for their preparation. | 07-23-2009 |
20100197951 | COMPOUNDS FOR PREPARING IMMUNOLOGICAL ADJUVANT - The present invention provides methods for preparing TLR-4 receptor agonist E6020: | 08-05-2010 |
20110060151 | REAGENTS AND METHODS FOR THE BETA-KETO AMIDE SYNTHESIS OF A SYNTHETIC PRECURSOR TO IMMUNOLOGICAL ADJUVANT E6020 - This invention relates to the synthesis for a precursor of E6020, compound 26, via a β-keto amide alcohol intermediate, compound 22. The synthesis reacts compound 22 with compound 25 and the resultant intermediate is oxidized to produce compound 26, the precursor to E6020. Compounds 22 and 25, and their crystalline forms, represent separate embodiments of the invention. The invention also relates to compounds of formulas (3) and (4) and processes for their preparation. | 03-10-2011 |
20120232298 | COMPOUNDS FOR PREPARING IMMUNOLOGICAL ADJUVANT - The present invention provides methods for preparing TLR-4 receptor agonist E6020: | 09-13-2012 |
20140012011 | COMPOUNDS FOR PREPARING IMMUNOLOGICAL ADJUVANT - The present invention provides methods for preparing TLR-4 receptor agonist E6020: | 01-09-2014 |
20140323739 | COMPOUNDS FOR PREPARING IMMUNOLOGICAL ADJUVANT - The present invention provides methods for preparing TLR-4 receptor agonist E6020: | 10-30-2014 |
Patent application number | Description | Published |
20120328486 | COMPOUND SAMPLE NEEDLE FOR LIQUID CHROMATOGRAPH - Described is a compound sample needle for a liquid chromatography system. In one embodiment, the compound sample needle includes a rigid needle having a coupling end with a face and a counterbore. The compound sample needle also includes a flexible tubing having an outer surface and a coupling end disposed in the counterbore of the rigid needle. The coupling end of the flexible tubing has a face adjacent to a base of the counterbore. The coupling ends of the rigid needle and flexible tubing are secured to each other by a weld formed along a circumference of the outer surface and the face of the rigid needle. A rigid sleeve protects the welded joint. The compound sample needle is suitable for injection into the high pressure mobile phase of ultra performance liquid chromatography systems. | 12-27-2012 |
20130008237 | NEEDLE SEAL FORCE SENSOR - Described are techniques for force sensing. A computing device is configured to have a desired force setting. A first vertical position of a needle is determined using the computer device. A control signal is sent from the computing device to a positioning device. In response to the control signal, the needle is positioned at the first vertical position. When in the first vertical position, surfaces of a tip of the needle are in contact with surfaces of an opening of a sealing member and positioning the needle causes application of a force at surfaces of the opening in contact with surfaces of the tip of the needle. In response to application of the force, a spring is compressed a distance that is proportional to the force. The force is measured using a force sensor. | 01-10-2013 |
20130019699 | INJECTION PORT NEEDLE SUPPORT AND WASHING - Described are techniques for use with an injection port. The injection port includes a needle support structure configured to accommodate a needle containing a sample aspirated therein. The injection port includes a needle seal having a first surface thereof in contact with a second surface of a tip of the needle. A seal is formed when the first surface contacts the second surface and a sufficient force is applied to the needle. | 01-24-2013 |
20150246296 | METHOD OF FRACTION COLLECTION FOR A LIQUID CHROMATOGRAPHY SYSTEM - Described are a fraction collector and a method of fraction collection for a liquid chromatography system. The method includes diverting a liquid chromatography system flow from a waste channel to a collection tube at a start of a fraction collection window and collecting the system flow dispensed from the collection tube during the fraction collection window. At the end of the window, the system flow is diverted to the waste channel and a flow of a wash solvent is provided to the collection tube to dispense liquid remaining in the collection tube at the end of the window from the collection tube. The method can increase the amount of the collected fraction and can reduce or eliminate cross-contamination of a subsequently collected fraction. The method is useful for analytical scale applications where the collected fractions may have volumes defined by a limited number of drops dispensed from the collection tube. | 09-03-2015 |
20150246351 | DISPENSING NEEDLE FOR A FRACTION COLLECTOR - Described is a dispensing needle for a fraction collector. The dispensing needle includes a conduit having a fluid channel to conduct a chromatographic system flow. The dispensing needle also includes a needle tip that has a fluid channel and an endface. The fluid channel of the needle tip is disposed at a dispensing end of the conduit and has a cross-sectional area that is less than a cross-sectional area of the fluid channel of the conduit. The fluid channels are in communication and enable a liquid chromatography system flow at a first velocity in the conduit to be dispensed at the endface of the needle tip at a second velocity that is greater than the first velocity. Advantageously, any droplets that may form at the endface of the needle tip are reduced in volume and therefore concentration variations for collected fractions are reduced. | 09-03-2015 |
20150247830 | DISPENSING NEEDLE FOR A FRACTION COLLECTOR - Described is a dispensing needle for a fraction collector. The dispensing needle includes a conduit having a fluid channel to conduct a chromatographic flow, an interior wall that defines the fluid channel, an exterior surface and an endface through which the chromatographic flow is dispensed. The dispensing needle also includes a coating of a hydrocarbon material or a fluorocarbon material that is bonded to the endface. The coating is also bonded to at least a portion of the exterior surface that is adjacent to the endface and at least a portion of the interior wall that is adjacent to the endface. The coating operates to reduce a droplet volume of a liquid dispensed from the endface that may remain at the tip of the dispensing needle. Consequently, the concentration variation in a collected fraction due to a missing droplet or extra droplet is reduced. | 09-03-2015 |
Patent application number | Description | Published |
20090266250 | Infinitely variable cut off printing press and method of varying cut off - A variable cutoff printing press is provided including a first plate cylinder with a first plate disposed about the first plate cylinder and having a first image portion. A first blanket cylinder transfers the first image portion to a web at a first location. A second plate having a second image portion is disposed about the second plate cylinder. A second blanket cylinder transfers the second image portion to the web at a second location. An impression cylinder contacts the first blanket cylinder and the second blanket cylinder via the web. The first image portion and the second image portion form one continuous image having an image cutoff length. A method of printing an image on a web with a cutoff using a variable cutoff offset printing press is also provided. | 10-29-2009 |
20100043658 | Printing press with replaceable sleeve shell segments for a cylinder - A variable-diameter printing press cylinder is provided. The variable-diameter printing press cylinder includes a cylinder body, a first shell segment having a first circumferential end portion and a second shell segment having a second circumferential end portion. The first and second shell segments are mounted on the cylinder body via the first and second circumferential end portions. A method of varying a circumference of a cylinder in a printing press and a printing press are also provided. | 02-25-2010 |
20100089265 | Infinitely variable cutoff printing press with constant speed plate cylinder and inker - A variable cutoff printing press is provided. The printing press includes a first plate cylinder rotating at a constant angular velocity and printing on a web during each revolution about a first plate cylinder axis and a first blanket cylinder rotating at varying angular velocities during each revolution about a first blanket cylinder axis. The first blanket cylinder comes in and out of contact with the first plate cylinder during operation. A method of variable cutoff printing is also provided. | 04-15-2010 |
20100126368 | Variable Cutoff Alignment Apparatus and Method of Aligning Printing Cylinders during a Cutoff Change - A variable cutoff cylinder alignment apparatus is provided. The variable cutoff cylinder alignment apparatus includes a plate cylinder support box for supporting an exchangeable variable cutoff plate cylinder, a blanket cylinder support box for supporting an exchangeable variable cutoff blanket cylinder and an alignment stop adapted to align the blanket cylinder support box and the plate cylinder support box. The plate cylinder support box supports an exchangeable plate cam and the blanket cylinder support box includes a blanket cam. The exchangeable plate cam is capable of contacting the stop and the exchangeable blanket cam is capable of contacting the plate support box to align the blanket cylinder support box and the plate cylinder support box. The plate cylinder support box and the blanket cylinder support box are capable of aligning cylinders of different sized cutoffs. A variable cutoff offset printing press and a method of aligning printing cylinders during a cutoff change are also provided. | 05-27-2010 |
20110185926 | VIBRATOR ASSEMBLY FOR AN INKING UNIT OR A DAMPENING UNIT OF A PRINTING PRESS - An offset printing press is provided including a plate cylinder and a fluid dispersing unit dispersing fluid to the plate cylinder. The fluid dispersing unit includes a vibrator roll, a shaft supporting the vibrator roll and a motor including a coil and a magnet. The coil is disposed about the magnet and the magnet or the coil is mounted on the shaft. The motor oscillates the vibrator roll axially. A vibrating assembly for a fluid dispersing unit of a printing press is also provided. | 08-04-2011 |
20140102326 | PRINTING PRESS INCLUDING BOWED AXIS ROLLERS AND METHOD OF PRINTING - A printing press is provided. The printing press includes a first printing unit including a first plate cylinder, a first blanket cylinder and a first impression cylinder forming a first printing nip with the first blanket cylinder, a first bowed roller upstream of the first printing unit spreading a web before the web enters the first printing nip, a second printing unit downstream of the first printing unit including a second plate cylinder, a second blanket cylinder and a second impression cylinder forming a second printing nip with the second blanket cylinder, and a second bowed roller between the first printing and the second printing unit, the second bowed roller spreading the web before the web enters the second printing nip. A method printing is also provided. | 04-17-2014 |