Patent application number | Description | Published |
20090175786 | Gastrin Releasing Peptide Compounds - New and improved compounds for use in diagnostic imaging or therapy having the formula M-N—O—P-G, wherein M is a metal chelator having the structure: | 07-09-2009 |
20110070165 | MULTIVALENT CONSTRUCTS FOR THERAPEUTIC AND DIAGNOSTIC APPLICATIONS - The invention provides compositions and methods for therapeutic and diagnostic applications. | 03-24-2011 |
20110097275 | KDR AND VEGF/KDR BINDING PEPTIDES AND THEIR USE IN DIAGNOSIS AND THERAPY - The present invention provides polypeptides, peptide dimers, and multimeric complexes comprising at least one binding moiety for KDR or VEGF/KDR complex, which have a variety of uses wherever treating, detecting, isolating or localizing angiogenesis is advantageous. Particularly disclosed are synthetic, isolated polypeptides capable of binding KDR or VEGF/KDR complex with high affinity (e.g., having a K | 04-28-2011 |
20110206606 | STABLE RADIOPHARMACEUTICAL COMPOSITIONS AND METHODS FOR PREPARATION - Stabilized radiopharmaceutical formulations are disclosed. Methods of making and using stabilized radiopharmaceutical formulations are also disclosed. The invention relates to stabilizers that improve the radiostability of radiotherapeutic and radiodiagnostic compounds, and formulations containing them. In particular, it relates to stabilizers useful in the preparation and stabilization of targeted radiodiagnostic and radiotherapeutic compounds, and, in a preferred embodiment, to the preparation and stabilization of radiodiagnostic and radiotherapeutic compounds that are targeted to the Gastrin Releasing Peptide Receptor (GRP-Receptor). | 08-25-2011 |
20110250133 | GASTRIN RELEASING PEPTIDE COMPOUNDS - Methods and compositions for diagnosing, staging disease, monitoring therapeutic effect of drugs and imaging a patient are provided, including radiopharmaceutical formulations. Compositions comprising Ga-AMBA complexed with a radioactive isotope are provided; as are methods of imaging Gastrin Releasing Peptide receptor (GRP-R) bearing tissue and methods of diagnosing or staging disease in patients suspected of having disease associated with aberrant GRP-R function. Further, methods of monitoring therapeutic effect of a drug targeted to a receptor that crosstalks with GRP-R are provided; as are methods of pre-dosing/co-dosing non-target tissues containing GRP-R. Particularly, methods of monitoring activity of receptors and receptor pathways in vivo/in vitro by using a ligand that binds to the GRP-R are provided; as are methods of measuring the activity of a receptor or group of receptors and their associated pathways that exhibit crosstalk with the GRP-R by using such a ligand which is also detectable by external means. | 10-13-2011 |
20110262366 | COMPOUNDS FOR TARGETING ENDOTHELIAL CELLS, COMPOSITIONS CONTAINING THE SAME AND METHODS FOR THEIR USE - The present invention provides compounds for targeting endothelial cells, tumor cells or other cells that express the NP-1 receptor, compositions containing the same and methods for their use. Additionally, the present invention includes diagnostic, therapeutic and radiotherapeutic compositions useful for visualization, therapy or radiotherapy. | 10-27-2011 |
20110280802 | Linkers For Radiopharmaceutical Compounds - A new and improved method for extending the half life of pharmaceutical compounds for use in diagnostic imaging or therapy uses a novel linker to attach a diagnostic or therapeutic moiety to a targeting peptide or another diagnostic or therapeutic moiety. The resulting compound may have the general formula M-N—O—P-Q, wherein M is the diagnostic or therapeutic moiety, N—O—P is the linker of the present invention, and Q is the targeting peptide. In another embodiment the compounds may have the formula M-N—O—P-M, wherein M is independently a diagnostic or therapeutic moiety and N—O—P is the linker of the invention. Methods for imaging or treating a patient using the compounds of the invention are also provided. Methods and kits for preparing a diagnostic imaging agent from the compound are further provided. Methods for radiotherapy of a patient using the compounds are further provided, as are methods for preparing a radiotherapeutic agent from the compounds. | 11-17-2011 |
20110286929 | MULTIVALENT CONSTRUCTS FOR THERAPEUTIC AND DIAGNOSTIC APPLICATIONS - The invention provides compositions and methods for therapeutic and diagnostic applications. | 11-24-2011 |
20120045393 | LHRH-II PEPTIDE ANALOGS - The invention is directed to analogs of LHRH-II and, more generally, to analogs of the LHRH family in which modifications have been made that confer enhanced binding affinity for LHRH receptors and/or improved metabolic stability. | 02-23-2012 |
20120065365 | Stable Radiopharmaceutical Compositions and Methods for Their Preparation - Stabilized radiopharmaceutical formulations are disclosed. Methods of making and using stabilized radiopharmaceutical formulations are also disclosed. The invention relates to stabilizers that improve the radiostability of radiotherapeutic and radiodiagnostic compounds and formulations containing them. In particular, it relates to stabilizers useful in the preparation and stabilization of targeted radiodiagnostic and radiotherapeutic compounds, and, in a preferred embodiment, to the preparation and stabilization of radiodiagnostic and radiotherapeutic compounds that are targeted to the Gastrin Releasing Peptide Receptor (GRP-Receptor). | 03-15-2012 |
20120315220 | Compounds for Targeting Endothelial Cells, Compositions Containing the Same and Methods for Their Use - The present invention provides compounds for targeting endothelial cells, tumor cells or other cells that express the NP-1 receptor, compositions containing the same and methods for their use. Additionally, the present invention includes diagnostic, therapeutic and radiotherapeutic compositions useful for visualization, therapy or radiotherapy. | 12-13-2012 |
20130136691 | GASTRIN RELEASING PEPTIDE COMPOUNDS - Methods and compositions for diagnosing, staging disease, monitoring therapeutic effect of drugs and imaging a patient are provided, including radiopharmaceutical formulations. Compositions comprising Ga-AMBA complexed with a radioactive isotope are provided; as are methods of imaging Gastrin Releasing Peptide receptor (GRP-R) bearing tissue and methods of diagnosing or staging disease in patients suspected of having disease associated with aberrant GRP-R function. Further, methods of monitoring therapeutic effect of a drug targeted to a receptor that crosstalks with GRP-R are provided; as are methods of pre-dosing/co-dosing non-target tissues containing GRP-R. Particularly, methods of monitoring activity of receptors and receptor pathways in vivo/in vitro by using a ligand that binds to the GRP-R are provided; as are methods of measuring the activity of a receptor or group of receptors and their associated pathways that exhibit crosstalk with the GRP-R by using such a ligand which is also detectable by external means. | 05-30-2013 |
20140161732 | KDR AND VEGF/KDR BINDING PEPTIDES AND THEIR USE IN DIAGNOSIS AND THERAPY - The present invention provides polypeptides, peptide dimers, and multimeric complexes comprising at least one binding moiety for KDR or VEGF/KDR complex, which have a variety of uses wherever treating, detecting, isolating or localizing angiogenesis is advantageous. Particularly disclosed are synthetic, isolated polypeptides capable of binding KDR or VEGF/KDR complex with high affinity (e.g., having a K | 06-12-2014 |
20140205545 | MULTIVALENT CONSTRUCTS FOR THERAPEUTIC AND DIAGNOSTIC APPLICATIONS - The invention provides compositions and methods for therapeutic and diagnostic applications. | 07-24-2014 |
20140286864 | KDR AND VEGF/KDR BINDING PEPTIDES AND THEIR USE IN DIAGNOSIS AND THERAPY - The present invention provides polypeptides, peptide dimer, and multimeric complexes comprising at least one binding moiety for KDR or VEGF/KDR complex, which have a variety of uses wherever treating, detecting, isolating or localizing angiogenesis is advantageous. Particularly disclosed are synthetic, isolated polypeptides capable of binding KDR or VEGF/KDR complex with high affinity (e.g., having a K | 09-25-2014 |
20150260855 | REAL TIME NUCLEAR ISOTOPE DETECTION - A radioisotope generator that releases a daughter radioisotope from radioactive decay of a corresponding parent isotope, such as a | 09-17-2015 |
20150374843 | MULTIVALENT CONSTRUCTS FOR THERAPEUTIC AND DIAGNOSTIC APPLICATIONS - The invention provides compositions and methods for therapeutic and diagnostic applications. | 12-31-2015 |
Patent application number | Description | Published |
20110191875 | COMPOSITIONS AND METHODS FOR MAKING ANDROSTENEDIONES - The invention provides compositions and methods for producing androstenedione (4-androstenedione), of improved purity and for modulating its production, for example by deletion or inactivation of ksdA, cxgA, cxgB, cxgC, or cxgD. The invention also provides methods and compositions, including nucleic acids that encode enzymes, for producing 1,4-androstadiene-3,17-dione (ADD) and related pathway compounds, including 20-(hydroxymethyl)pregna-4-en-3-one and 20-(hydroxymethyl)pregna-1,4-dien-3-one. The compositions of the invention include nucleic acids, probes, vectors, cells, transgenic plants and seeds, transgenic animals, kits and arrays. | 08-04-2011 |
20130029393 | RECOMBINANT ETHANOLOGENIC BACTERIA - The invention provides recombinant ethanologenic bacteria, methods of making the bacteria and methods of producing ethanol using the bacteria. | 01-31-2013 |
Patent application number | Description | Published |
20100310893 | ENGINEERED WOOD PRODUCT - Engineered wood products, methods of making the products, laminates including the products, and articles of manufacture which include the engineered products or composites, are disclosed. The products include wood and/or other cellulosic fibers, and can include non-cellulosic fibers, all or part of which can be derived from post-industrial and/or post-consumer materials. The products also include a binding agent, such as a latex dispersion, as well as hydrophobic materials, processing aids, colorants, and the like. The product can be in the form of a sheet, a three dimensional article or a plurality of laminated sheets, and can include one or more additional layers, such as top coat layers, reinforcing layers, cushioning layers, wood veneer layers, and/or additional product layers. The products can be used as flooring, and in construction, cabinetry, and the like. | 12-09-2010 |
Patent application number | Description | Published |
20090326758 | WEBSERVICE ARCHITECTURE FOR VEHICLE HEALTH MAINTENANCE - A webservice architecture for vehicle health maintenance is provided. A core module is in communication with a webservice provider, a webservice consumer, and a webservice registry over an internet protocol (IP) backbone. The core module is adapted for registering and discovering the webservice provider using a universal description, discovery, and integration (UDDI) communications open standard, receiving a request from the webservice provider using a simple object access protocol (SOAP), the webservice provider accepting the request from the webservice consumer, and extracting a data structure based on the webservice request in a format according to the webservice registry using a web services description language (WDSL). | 12-31-2009 |
20090326782 | AIRCRAFT GAS TURBINE ENGINE CONTROLLER WITH REMOVABLE MEMORY AND DIAGNOSTIC SYSTEM AND METHOD THEREFOR - A system and method of analyzing aircraft gas turbine engine performance data includes receiving, in an engine controller, engine performance data representative of a plurality of aircraft gas turbine engine parameters. At least a portion of the received engine performance data are stored in a fixed memory device that is fixedly coupled to a fixed-memory mount in the engine controller, and in a removable memory device that is non-fixedly coupled to a removable memory mount in the engine controller in a manner that allows the removable memory device to be hand-removable from the removable memory mount. The removable memory device is removed from the removable memory mount in the engine controller, and inserted in a port of a computing device that is not coupled to the engine controller. | 12-31-2009 |
20090327325 | META MODELING IN DECISION SUPPORT SYSTEM - A method, system, and computer program product for providing troubleshooting data for reported fault conditions on equipment is provided. An engineering model is configured for the equipment. The engineering model includes at least one failure scenario and an associated symptom. The engineering model is stored in an equipment model database. A meta model representative of at least one relationship between the engineering model and a reported fault condition for the equipment is instantiated. A user input for the reported fault condition is stored in a decision support system (DSS) database. The DSS database forms a wrapper over the equipment model database based on the user input. The meta model is further instantiated using user input data from the DSS database. An optimal troubleshooting procedure for the equipment is determined based on the meta model as instantiated. | 12-31-2009 |
20090327796 | SERVICE ORIENTED ARCHITECTURE BASED DECISION SUPPORT SYSTEM - A service oriented architecture (SOA) based decision support system for a vehicle is provided. A database is provided for storing a workplan of the vehicle. A webservice provider is in communication with the database for integrating applications using a variety of open standards of an internet protocol backbone. A core is connected between the database and webservice provider. The core is adapted for analyzing fault conditions, creating the workplan to overcome the fault conditions, and generating a response for a webservice request. An enterprise service bus is connected to the webservice provider for providing loose connectivity between webservice enabled functions, a service customer, and the core. | 12-31-2009 |
Patent application number | Description | Published |
20140259417 | INFLATABLE AIR MATTRESS SNORING DETECTION AND RESPONSE - A method can be provided that includes measuring sound waves using a sound measuring device, determining, at a central controller of an air mattress system, one or more parameter values of the sound waves, comparing the one or more parameter values with values, ranges, or patterns indicative of snoring, identifying a snoring state of a user, and initiating, with the central controller, a change to one or more adjustable features of the air mattress system. | 09-18-2014 |
20140259418 | INFLATABLE AIR MATTRESS WITH LIGHT AND VOICE CONTROLS - In one example, this disclosure describes a method including determining, at a central controller of an air mattress system, whether a user is present on a mattress of the air mattress system, initiating a timer in response to determining that the user is present on the mattress, enabling a light control feature of the air mattress system upon determining that the user is present on the mattress after expiration of the timer, and after enabling the light control feature, transmitting, from the central controller, at least one instruction to turn on at least one light of the air mattress system in response to determining that the user is no longer present on the mattress. | 09-18-2014 |
20140259433 | INFLATABLE AIR MATTRESS ALARM AND MONITORING SYSTEM - This disclosure describes, among other things, techniques for waking a user by changing the user's sleep environment. In one example, a method includes receiving, at a central controller of an air mattress system, at least one user alarm setting, generating, via the central controller, at least one instruction based on the received user alarm setting, and transmitting, from the central controller, the at least one instruction to a first component of the air mattress system to adjust a feature of the first component. | 09-18-2014 |
20140259434 | INFLATABLE AIR MATTRESS SYSTEM WITH DETECTION TECHNIQUES - In one example, this disclosure describes a method including receiving, at a central controller of an air mattress system, a plurality of air pressure value, determining a plurality of average values using the plurality of the received air pressure values, calculating a difference value between a first one of the plurality of average values and a second one of the plurality of average values, comparing the difference value to a threshold value, determining, based on the comparison, whether a user of the air mattress system moved. | 09-18-2014 |
20140277611 | INFLATABLE AIR MATTRESS SYSTEM ARCHITECTURE - A method may comprise receiving, at a central controller, a command, from a remote control, to adjust a feature of a first component of an air mattress framework; relaying, from the central controller, the command to the first component; receiving from the first component at the central controller, an indication of the success of the command; and relaying the indication from the central controller to the remote control. | 09-18-2014 |
20140277778 | INFLATABLE AIR MATTRESS AUTOFILL AND OFF BED PRESSURE ADJUSTMENT - A method and system may include transmitting a signal to a pump of an air mattress to set the pressure of the air mattress to an initial pressure; receiving, at a central controller, a user preference condition for an automatic adjustment of the pressure in the air mattress; receiving, at the central controller, an indication that the air mattress is empty; and based on determining that the user preference condition has been met and receiving the indication: detecting a change in the pressure of the air mattress beyond a threshold value; and based on the detection, adjusting the pressure of the air mattress to the initial pressure. | 09-18-2014 |
20140277822 | INFLATABLE AIR MATTRESS SLEEP ENVIRONMENT ADJUSTMENT AND SUGGESTIONS - A method may include receiving a setting for a component of a bed architecture and a trigger condition for the setting; generating a sleep profile with the setting and trigger condition; activating the sleep profile when the trigger condition has been met; and based on the activation of the sleep profile, transmitting a signal to the component to adjust to the setting. | 09-18-2014 |
Patent application number | Description | Published |
20100269629 | LOW FRICTION SLOTTED BEARING AND LINK APPARATUS - A low friction load slot bearing assembly has a ball and an outer race in which the ball is positioned. The outer race includes an inner engagement surface contoured to a shape complementary to an outer surface of the ball, a first slot located in a face of the outer race, a second slot located in the face of the outer race, and a lubricous liner disposed on the inner engagement surface and on surfaces defining the slots. The low friction aspect is imparted to the load slot bearing assembly via the lubricious liner. The ball slidably and rotatably engages the inner engagement surface of the outer race. A load slot bearing system includes a low friction load slot bearing assembly interconnecting two elements. A link apparatus includes a cylindrical member and two low friction load slot bearing assemblies located on or at opposing ends of the cylindrical member. | 10-28-2010 |
20130163905 | HIGH-CYCLE, SHORT RANGE-OF-MOTION LINKAGE APPARATUS FOR GAS TURBINE ENGINE APPLICATIONS - A high-cycle, short range-of-motion linkage apparatus is provided for actuation of a positioning device. The linkage apparatus includes a pivot member having a stem extending therefrom, a positioning member including a receiving portion into which the stem is removably secured, and at least one spherical plain bearing secured to the pivot member. The spherical plain bearing has an inner member having an outer engagement surface and a bore extending at least partway therethrough, an outer member positioned at least partially around the inner member, the outer member having an inner engagement surface contoured to a shape complementary to the outer engagement surface of the inner member, and a liner disposed between the inner engagement surface of the outer member and the outer engagement surface of the inner member, the liner comprising polytetrafluoroethylene and a phenolic resin reinforced with aramid fibers. | 06-27-2013 |
20140294484 | LOW FRICTION BEARING ASSEMBLY AND LINK APPARATUS - A link apparatus includes a tubular member that retains 90% of ultimate tensile strength at a temperature of up to 625°. Two conical adapters are mechanically joined to respective ends of the tubular member. Two rod ends include a threaded shank and a socket. One threaded shank is threaded into a right hand threaded base of one conical adapter, and the other threaded shank is threaded into a left hand threaded base of the other conical adapter. Each of the sockets have a bearing assembly disposed therein including an outer race, a ball disposed therein, and a low-friction liner disposed between the outer race and ball for mitigating moment loading on the tubular member. The cross-sectional area of the tubular member is about equal to the cross sectional area of the rod ends. The tubular member is tensionable by rotation relative to the rod ends. | 10-02-2014 |
Patent application number | Description | Published |
20130145854 | LINKED BRIDGE PRESSURE TRANSDUCER ASSEMBLIES - A gage/differential pressure transducer assembly having enhanced output capabilities, comprising a first pressure port adapted to communicate a first pressure to a first sensor, the first sensor comprising a first Wheatstone bridge adapted to output a first signal indicative of the first pressure, wherein the first pressure is a main pressure; and a second pressure port adapted to communicate a second pressure to a second sensor, the second sensor comprising a second Wheatstone bridge adapted to output a second signal indicative of the second pressure, wherein the second pressure is a reference pressure; and an output port connected to the first Wheatstone bridge and the second Wheatstone bridge for outputting a third signal representative of the difference between the first and second pressures. | 06-13-2013 |
20150204746 | COMPENSATING A SENSOR HAVING THERMAL GRADIENTS - This disclosure provides example methods, devices, and systems for compensating a sensor having thermal gradients. In one embodiment, a system may comprise a sensor, including a first half-bridge transducer, wherein the first half-bridge transducer is configured to receive a first pressure, measure the first pressure and output a first pressure signal associated with the first pressure; a first set of span resistors coupled to the first half-bridge transducer, wherein the first set of span resistors is configured to compensate the first pressure signal for a thermal sensitivity shift associated with the first half-bridge transducer to generate a first compensated pressure signal; a second half-bridge transducer, wherein the second half-bridge transducer is configured to receive a second pressure, measure the second pressure, and output a second pressure signal associated with the second pressure; a second set of span resistors coupled to the second half-bridge transducer, wherein the second set of span resistors is configured to compensate the second pressure signal for a thermal sensitivity shift associated with the second half-bridge transducer to generate a second compensated pressure signal; and wherein an output signal associated with a difference between the first compensated pressure signal and the second compensated pressure signal is output from the sensor. | 07-23-2015 |
Patent application number | Description | Published |
20110057302 | IMPEDANCE OPTIMIZED CHIP SYSTEM - A high bandwidth circuit is segmented into a plurality of portions, each portion for implementation on a corresponding semiconductor chip, an arrangement of one or more die bond pads for each corresponding chip is generated, and a chip location for each corresponding chip is generated, given package and given package I/O arrangement is generated, the generation of the die bond arrangements and the chip position being relative to given chip package parameters, and being generated to establish bond wire lengths meeting given characteristic impedance parameters. Boundary parameters for generating the segmenting are provided, including a bound on the number of portions and optionally a including bound on the area parameters of the corresponding semiconductor chips. | 03-10-2011 |
20130268909 | IMPEDANCE OPTIMIZED CHIP SYSTEM - A high bandwidth circuit is segmented into a plurality of portions, each portion for implementation on a corresponding semiconductor chip, an arrangement of one or more die bond pads for each corresponding chip is generated, and a chip location for each corresponding chip is generated, given package and given package I/O arrangement is generated, the generation of the die bond arrangements and the chip position being relative to given chip package parameters, and being generated to establish bond wire lengths meeting given characteristic impedance parameters. Boundary parameters for generating the segmenting are provided, including a bound on the number of portions and optionally a including bound on the area parameters of the corresponding semiconductor chips. | 10-10-2013 |
20140009001 | DIFFERENTIAL RETURN LOSS SUPPORTING HIGH SPEED BUS INTERFACES - Various aspects of the present disclosure are directed toward methods and apparatus that include a lead frame with a fixed external pin pitch. A differential signal path is provided that is characterized by bond-pad pitch range, wire length and wire diameter. The differential signal path carries signals in a frequency range between 5 GHz and 16.1 GHz with less than about 25 dB differential return loss (DDRL). Further, the signals are processed at a signal-processing node that is electrically coupled to the differential signal path by using the differential signal path to carry signals in a frequency range between 5 GHz and about 16.1 GHz. | 01-09-2014 |