Patent application number | Description | Published |
20090260774 | SACRIFICIAL SLEEVES FOR DIE CASTING ALUMINUM ALLOYS - Some die cast aluminum alloy articles have internal cylindrical surfaces such as the round internal cylinder surfaces of a cylinder block for an internal combustion engine. During casting solidification molten aluminum alloys shrink against the metallic permanent mold tools used to mold and define such internal surfaces, and tend to stick to the tool surfaces making it difficult to remove the casting. The tendency of some aluminum casting alloys to solder to the tool can further intensify sticking. In this invention, an aluminum alloy sleeve is placed on and over the tool surface before casting and the sleeve isolates the tool from the molten aluminum. The sleeve becomes bonded to the casting and facilitates removal of the casting from the tool. The sleeve may be (and preferably is) fully machined from the internal casting surface. The sleeve may be of the same composition as the casting, in which case handling and recycling of machining chips would be facilitated. The practice of the invention is also applicable to die casting of magnesium alloys using magnesium sacrificial sleeves. | 10-22-2009 |
20100030537 | METHODS AND SYSTEMS FOR PREDICTING VERY HIGH CYCLE FATIGUE PROPERTIES IN METAL ALLOYS - A system and method for predicting fatigue life in metal alloys for very high cycle fatigue applications. The system and method are especially useful for cast metal alloys, such as cast aluminum alloys, where a fatigue endurance limit is either non-existent or hard to discern. Fatigue properties, such as fatigue strength in the very high cycle fatigue region, are based on a modified random fatigue limit model, where the very high cycle fatigue strength and infinite life fatigue strength are refined to take into consideration the sizes of the discontinuities and microstructure constituents since the fatigue life scatter depends upon the presence of discontinuities and microstructure constituents. The sizes of the discontinuities and microstructure constituents that can initiate fatigue cracks can be determined with extreme value statistics, then input to the modified random fatigue limit model. | 02-04-2010 |
20100273023 | METHOD OF FORMING A COATED ARTICLE INCLUDING A MAGNESIUM ALLOY - A method of forming a coated article is disclosed. The method involves heating a magnesium alloy component, positioning the component in a mold such that a gap exists between component outer surfaces and mold inner surfaces, and heating a magnesium-containing alloy material above its melting temperature, which is lower than that of the component. The material is formed from magnesium alloyed with i) the component element, but at a higher concentration, ii) at least one element that is different than the component element, or iii) the component element and at least one other element. The method further includes introducing the material into the gap, thereby covering at least the outer surfaces of the component, and cooling the material to form a substantially evenly distributed solidified coating on the outer surfaces of the component. The coating has a higher wear and/or corrosion resistance than that of the magnesium alloy component. | 10-28-2010 |
20100300394 | METAL ALLOY CASTINGS WITH CAST-IN-PLACE TUBES FOR FLUID FLOW - A major engine casting, such as an engine block or a cylinder head, fabricated of either magnesium or aluminum alloy, has a cast-in-place metal tube or form embedded within it. The tube or form enables circulation of liquid while substantially physically isolating the casting alloy from the circulating liquid and thereby restricting or eliminating corrosive interaction between them. | 12-02-2010 |
20120227699 | LINERLESS ENGINE - A linerless engine includes a casting defining a bore having an inner surface and a central longitudinal axis. The casting is formed from a castable aluminum-silicon alloy including silicon particles present a range of from about 11 to about 12.5 parts by weight. The inner surface has a surface variation defined by at least some of the silicon particles protruding toward the axis for from about 0.6 to about 1.5 microns. The linerless engine includes a piston slideably disposed within the bore and configured for translating along the axis, wherein the piston is formed from an aluminum alloy and includes a body having a skirt portion coated with a first coating, and at least one ring encircling and in contact with the body. The ring is coated with a diamond-like coating that is free from degradation when in contact with the at least some of the silicon particles. | 09-13-2012 |
20120301669 | METHOD OF BONDING A METAL TO A SUBSTRATE - A method of bonding a metal to a substrate involves forming a plurality of nano-features in a surface of the substrate, where each nano-feature is chosen from a nano-pore and/or a nano-crevice. In a molten state, the metal is over-cast onto the substrate surface, and penetrates the nano-features. Upon cooling, the metal is solidified inside the nano-features, where the solidification of the metal forms a mechanical interlock between the over-cast metal and the substrate. | 11-29-2012 |
20120301734 | METHOD OF BONDING A METAL TO A SUBSTRATE - A method of bonding a metal to a substrate involves forming an oxide layer on a surface of the substrate, and in a molten state, over-casting the metal on the substrate surface. The over-casting drives a reaction at an interface between the over-cast metal and the oxide layer to form another oxide. The other oxide binds the metal to the substrate surface upon solidification of the over-cast metal. | 11-29-2012 |
20120301743 | METHOD OF BONDING A METAL TO A SUBSTRATE - A method of bonding a metal to a substrate is disclosed herein. The method involves forming a nano-brush on a surface of the substrate, where the nano-brush includes a plurality of nano-wires extending above the substrate surface. In a molten state, the metal is introduced onto the substrate surface, and the metal surrounds the nano-wires. Upon cooling, the metal surrounding the nano-wires solidifies, and during the solidifying, at least a mechanical interlock is formed between the metal and the substrate. | 11-29-2012 |
20130101780 | METHOD OF FORMING A COMPONENT HAVING AN INSERT - A component includes a cast portion and an insert. The cast portion includes a sacrificial suspension device. The insert is configured to provide damping to the component. The sacrificial suspension device is dissolved during a casting process, into a molten material, forming the cast portion such that the insert is fully encapsulated by the cast portion, including the dissolved suspension device. | 04-25-2013 |
20140242452 | LITHIUM ION BATTERY - A lithium-ion cell has a positive electrode comprising at least one active material comprising a lithium transition metal compound in a binder comprising at least one binder material with functional groups selected from alkali and alkaline earth salts of acid groups and hydroxyl groups, amine groups, isocyanate groups, urethane groups, urea groups, amide groups, and combinations of these; a negative electrode comprising metallic lithium or a lithium host material with appropriately low operation voltage vs. metallic lithium; a nonaqueous solution of a lithium salt; and an electrically nonconductive, ion-pervious separator positioned between the electrodes. | 08-28-2014 |
20140272584 | METHOD FOR PRE-LITHIATION OF THE NEGATIVE ELECTRODE IN LITHIUM ION BATTERIES - A Li-ion battery is disclosed, the Li-ion battery including an anode, a cathode, a lithium donor formed from a Li-containing material, and an electrolyte in communication with the anode, the cathode, and the lithium donor. The lithium donor may be incorporated into the anode, incorporated into the cathode, a layer formed on either an anode side or a cathode side of a separator of the battery. The lithium donor is formed from Li-containing material insensitive to oxygen and aqueous moisture. | 09-18-2014 |
Patent application number | Description | Published |
20140099309 | Use of a Trans-Signaling Approach in Chimeric Antigen Receptors - The present invention provides compositions and methods for inducing a CAR mediated trans-signal in a T cell. The trans-signaling CAR T cells comprise a first CAR having a first signaling module and a second CAR having a distinct second signaling module. The present invention also provides cells comprising a plurality of types of CARs, wherein the plurality of types of CARs participate in trans-signaling to induce T cell activation. | 04-10-2014 |
20140234348 | Universal Immune Receptor Expressed by T Cells for the Targeting of Diverse and Multiple Antigens - The invention provides compositions and methods for adoptive T cell therapy in treating a variety of disorders including cancer, infections, and autoimmune disorders. In one embodiment, the invention provides a universal immune receptor (UnivIR) that comprises an extracellular label binding domain, a transmembrane domain, and a cytoplasmic domain or otherwise an intracellular domain. | 08-21-2014 |
20140286973 | CHIMERIC ANTIGEN RECEPTOR SPECIFIC FOR FOLATE RECEPTOR BETA - The invention provides compositions and methods for treating leukemia, for example, acute myeloid leukemia (AML). The invention also relates to at least one chimeric antigen receptor (CAR) specific to folate receptor beta (FRβ), vectors comprising the same, and recombinant T cells comprising the FRβ CAR. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises a FRβ binding domain in combination with a RXR agonist, such as all-trans retinoic acid. | 09-25-2014 |
20140301993 | FULLY HUMAN, ANTI-MESOTHELIN SPECIFIC CHIMERIC IMMUNE RECEPTOR FOR REDIRECTED MESOTHELIN-EXPRESSING CELL TARGETING - The present invention relates to compositions and methods for treating diseases, disorders or conditions associated with dysregulated expression of mesothelin. In one embodiment, the invention relates to a fully human chimeric antigen receptor (CAR) wherein the CAR is able to target mesothelin. | 10-09-2014 |
20150225480 | HUMAN ALPHA-FOLATE RECEPTOR CHIMERIC ANTIGEN RECEPTOR - The invention provides compositions and methods for treating ovarian cancer. Specifically, the invention relates to administering a genetically modified T cell having alpha-folate receptor (FR-alpha) binding domain and CD27 costimulatory domain to treat ovarian cancer. In an embodiment, the FR-alpha binding domain is fully human, thereby preventing a host immune response. | 08-13-2015 |
Patent application number | Description | Published |
20120123973 | METHOD OF ASSIGNING A RELATIVE SEMINALITY SCORE TO INDIVIDUAL PATENTS WITHIN A PATENT LANDSCAPE - A method for assigning a relative score to patents within a patent landscape is described, with the objective of being able to compare any two or more patents. A patent is considered seminal if the novelty of the invention is not a product of variations of prior art and spawns a new direction in intellectual property as described by new patents that come later. The method described in this document is one that combines a number of direct and indirect network factors and tempers the method by considering proximity to other patents within the landscape, incestuous citations, and other metric quantities inherent in the patent documents and from publicly available information. The method described is a relativistic model that is generic in that it does not depend on specific success of any individual patent to produce revenue or to fend off exposure to other specified intellectual property. | 05-17-2012 |
20120123974 | METHOD OF ASSIGNING A RELATIVE SEMINALITY SCORE TO INDIVIDUAL PATENTS WITHIN A PATENT LANDSCAPE - A method for assigning a relative score to patents within a patent landscape is described, with the objective of being able to compare any two or more patents. A patent is considered seminal if the novelty of the invention is not a product of variations of prior art and spawns a new direction in intellectual property as described by new patents that come later. The method described in this document is one that combines a number of direct and indirect network factors and tempers the method by considering proximity to other patents within the landscape, incestuous citations, and other metric quantities inherent in the patent documents and from publicly available information. The method described is a relativistic model that is generic in that it does not depend on specific success of any individual patent to produce revenue or to fend off exposure to other specified intellectual property. | 05-17-2012 |
20120239591 | METHOD OF CALCULATING THE MARKET VALUE OF INDIVIDUAL PATENTS WITHIN A PATENT LANDSCAPE - A method for deriving patent market value estimates within a patent landscape utilizing a relative metric score for all patents in the landscape, calibrating said market values by using a percentage of the known market values of patent portfolio owners, for example publicly traded companies with known patent portfolios. This method is based on the premise that the patents owned by said entities contribute to the market values of these entities, and describes a complete end-to-end process for estimating the market values for all patents within a patent landscape. This method also includes a set of steps useful for estimating the amount of revenue some patents may generate. | 09-20-2012 |
20120254185 | METHOD OF CATEGORIZING AN INVENTION WITHIN AN INVENTION LANDSCAPE - A computer-based method is described for categorizing inventions within the context of an invention landscape. A set of key phases is employed based upon the likelihood that the description of the invention to be categorized will share these key phrases with the descriptions of similar inventions from within the invention landscape. The results are ranked in such a way as to enable a tentative assignment of the target invention to one or more categories, and to optionally estimate the value of the invention. | 10-04-2012 |
20120254187 | METHOD OF CATEGORIZING AN INVENTION WITHIN AN INVENTION LANDSCAPE - A computer-based method is described for categorizing inventions within the context of an invention landscape. A set of key phases and/or semantic properties is employed based upon the likelihood that the description of the invention to be categorized will share these key phrases and/or semantic properties with the descriptions of similar inventions from within the invention landscape. The results are ranked in such a way as to enable a tentative assignment of the target invention to one or more categories, and to optionally estimate the value of the invention. | 10-04-2012 |
20130212030 | METHOD OF VALUING A PATENT USING METRIC CHARACTERISTICS OF SIMILAR PATENTS GRANTED EARLIER - A method of valuing a patent using metric characteristics of similar patents granted earlier, whereas said metrics comprise a variety of estimated future characteristics, normalized using estimated future market size. Similar patents are identified using a combination of one or more metric characteristics, for example, patent value estimate, semantic similarity, dependent claim counts, cited patent counts, word counts, patent counts within assigned classes/subclasses, and distinct assignee counts. | 08-15-2013 |