Patent application number | Description | Published |
20080318266 | FLUORESCENCE POLARIZATION INSTRUMENTS AND METHODS FOR DETECTION OF EXPOSURE TO BIOLOGICAL MATERIALS BY FLUORESCENCE POLARIZATION IMMUNOASSAY OF SALIVA, ORAL OR BODILY FLUIDS - The inventive subject matter relates to a method for detecting the presence of a biological substance of interest in a test sample of saliva or oral fluid, comprising combining said test sample with a fluorescence-labeled ligand to said biological substance and detecting a change in the fluorescence polarization of said test sample produced by binding of said fluorescence-labeled ligand to said biological substance. In one aspect of the inventive subject matter, said method comprises additional steps for comparing the fluorescence polarization of said test sample with the fluorescence polarization of a control solution. Also provided is a miniaturized, portable apparatus for measuring the fluorescence polarization of a liquid sample. | 12-25-2008 |
20110194975 | SEMICONDUCTOR-BASED DETECTION AND DECONTAMINATION SYSTEM - A system and method for identifying and making quantitative determinations of different deposits on a portion thereof, determining that the deposit is a contaminant and decontaminating at least the portion of the system is disclosed. The system comprises a controller, a sensing portion and a decontamination portion. The controller contains information about at least one noncontaminant. The sensing portion communicates with at least the controller and the portion of the system and is adapted to detect the deposit. The decontaminating portion communicates with at least the controller and is adapted to decontaminate the portion of the system. | 08-11-2011 |
20130078145 | SEMICONDUCTOR-BASED DETECTION AND DECONTAMINATION SYSTEM - A system for identifying and making quantitative determinations with respect to deposits on a portion of the system, determining that the deposit is a contaminant, and decontaminating at least the portion of the system is described. The system uses an embedded controller. It further includes an embedded sensing portion monitoring an atmosphere above the sensing portion. The sensing portion communicates with at least said controller and detects a quantity of the deposits. The sensing portion can be a film layer on a surface. The system also includes an embedded self-decontaminating portion. | 03-28-2013 |
Patent application number | Description | Published |
20110010336 | Computerized System And Method For Tracking The Geographic Relevance Of Website Listings And Providing Graphics And Data Regarding The Same - The present invention generally relates to a computerized system and method for tracking and displaying data identifying the geographic relevance of website listings on Internet search engines, parked web pages, ISP redirect web pages, and other similar web listing services without requiring extra input from Internet users. Each time an Internet user clicks on a website link provided on one of these web services, the software of the present invention tracks that person's decision in selecting the link, along with his or her geographic location. The software automatically collects and stores this information in a database in a format that can be quickly accessed and used in the future when other Internet users perform the same keyword search or visit the parked/redirect page again. Based on this stored information, the software automatically sends signals to the Internet user's computer that causes his or her web browser to display data and graphics that indicate whether the websites listed on the web page has been frequently visited and found to be popular by other Internet users in various geographic areas. As a result, the software of the present invention enables search engines, parked/redirect web pages, and other similar web services to be automatically organized by popularity within a geographic region. Moreover, each time data is collected by this software (e.g., when a user selects a link), the search engine and parked page will grow naturally and intelligently, thereby becoming more and more useful to the Internet user. | 01-13-2011 |
20110218961 | Computerized system and method for tracking the geographic relevance of website listings and providing graphics and data regarding the same - A computer-implemented method includes the steps of accessing, using one or more processors, data relating to visitors who have visited one or more websites, determining, using one or more processors, geographic areas corresponding to locations of the visitors, receiving, using one or more processors, one or more signals indicating a first request to provide at least a portion of data to be provided on a webpage, determining, using one or more processors, a geographic area from where the request originates; generating, using one or more processors, a subset of the data that pertains to the requested data based on: relevancy of the requested data to the geographic area from where the request originates, and relevancy of the requested data to the visitors that are located in or near the geographic area from where the request originates; and providing, using one or more processors, the subset of the data; and providing, using one or more processors, data that indicates whether or not the visitors found each item in the subset to be relevant to one or more geographic regions related to the geographic area from where the request originates. | 09-08-2011 |
20120150901 | Computerized System and Method for Tracking the Geographic Relevance of Website Listings and Providing Graphics and Data Regarding the Same - A computer-implemented method and system acceses data from user computers related to corresponding users who have referenced one or more websites. Geographic areas corresponding to locations of the users are determined. One or more signals indicating a request to provide at least a portion of data to be provided on a webpage are received from a requestor computer, where the at least a portion of data relates to the one or more websites. A request geographic area from where the request originates is determined. A subset of the data that pertains to the requested data based on relevancy of the requested data to the request geographic area and relevancy of the requested data to the user geographic areas located inside and outside the request geographic area is generated. The subset of the data is provided. Data is provided to the requestor's computer that indicates whether or not the users found each item in the subset to be relevant to the user geographic areas located inside and outside the request geographic area. An interface is provided to the requestor's computer for reorganizing the subset according to each of the one or more user geographic areas located inside and outside the request geographic area. | 06-14-2012 |
Patent application number | Description | Published |
20140249941 | MOBILE SCANNER GUN SYSTEM WITH MOBILE TABLET HAVING A MOBILE POS AND ENTERPRISE RESOURCE PLANNING APPLICATION FOR POS CUSTOMER ORDER FULFILLMENT AND IN STORE INVENTORY MANAGEMENT FOR RETAIL ESTABLISHMENT - A mobile scanner gun system is designed for a retail store with integrated mobile tablet device carried by employees. The mobile tablet device is connected to the pistol gun base housing through a base mount universal receiver with rotational coupling, and communicates to a USB barcode scanner/reader and MSR through a specialized universal serial bus wiring harness. The Main PCB has an EEPROM controlling operations of a scanner and an MSR. The mobile tablet device has mobile applications which allow wireless communication in the form of Wi-Fi or wireless cellular with a POS store systems server and corporate ERP system, and also commands the EEPROM. Merchandise to be purchased is scanned and received by the mobile tablet device and then sent wirelessly to the POS store systems server and corporate ERP system to obtain product data concerning description, price, inventory, electronic and physical coupon, promotions, customer loyalty data and rewards. | 09-04-2014 |
20140249942 | MOBILE BARCODE SCANNER GUN SYSTEM WITH MOBILE TABLET DEVICE HAVING A MOBILE POS AND ENTERPRISE RESOURCE PLANNING APPLICATION FOR CUSTOMER CHECKOUT / ORDER FULFILLMENT AND REAL TIME IN STORE INVENTORY MANAGEMENT FOR RETAIL ESTABLISHMENT - A mobile scanner gun system efficiently and reliably processes a retail store purchase and/or performs daily store inventory management functions. The system has a main body portion extending toward a handle portion, the main body portion having a base, side walls, a front wall and a back wall constructed to form an interior cavity, wherein the front wall includes an aperture with a lens recessed therein. The front wall has a trigger member located near the base of the main body. A USB MSR input device integrated on the short edge of the mobile tablet device (upper receiver) is used for processing payment card sales transactions through a secured PCI compliant, end to end encrypted bank card processor. The mobile tablet device has a system integrated therein that enables real-time store level inventory management and fully functioning POS capability for selling merchandise in a retail sales environment. | 09-04-2014 |
20140249943 | WEARABLE MOBILE SCANNER SYSTEM WITH MOBILE TABLET HAVING A MOBILE POS AND ENTERPRISE RESOURCE PLANNING APPLICATION FOR POS CUSTOMER ORDER FULFILLMENT AND METHOD IN STORE INVENTORY MANAGEMENT FOR RETAIL ESTABLISHMENT - A retail store purchasing system has a plurality of wearable mobile scanner systems with mobile tablet devices integration capability therein adapted to be carried by employees. Each wearable mobile scanner system comprises a mobile tablet device attached to a wearable base housing directly below it, and connected by a base mount universal receiver with rotational coupling. The Main PCB has an EEPROM controlling operations of a USB scanner and MSR. The mobile tablet device has an application which allows wireless communication with a POS store systems server and also commands the EEPROM. A product to be purchased is scanned by activating a button associated with said wearable mobile scanner system. This scanned data is received through the Main PCB to the mobile tablet device USB port and is sent wirelessly to the POS store systems server to obtain product data concerning description, price, inventory and promotions. | 09-04-2014 |
20140249944 | WEARABLE MOBILE SCANNER SYSTEM WITH MOBILE TABLET HAVING A MOBILE POS AND ENTERPRISE RESOURCE PLANNING APPLICATION FOR POS CUSTOMER ORDER FULFILLMENT AND IN STORE INVENTORY MANAGEMENT FOR RETAIL ESTABLISHMENT - A wearable mobile scanner system processes a retail store purchase in a convenient, time efficient and reliable manner. The wearable mobile scanner system includes a forearm portion and a hand portion. The forearm portion comprises a main body member and at least one strap member and is adapted to secure the forearm portion upon a user's forearm. The hand portion comprises a central forehand member, a palm member, and a forefinger aperture, wherein the hand portion is aligned with the forearm portion and wherein the hand portion is adapted to receive a hand of the user. A trigger member is located on the forefinger aperture in communication with a USB scanner input device mounted on the central forehand member of the hand portion. A system integrated therein enables store level real-time inventory management and a fully functioning mobile POS for selling merchandise throughout the store and beyond its walls. | 09-04-2014 |
20140249947 | STORE MOBILE CLOUD APPLICATION SYSTEM FOR INVENTORY MANAGEMENT AND CUSTOMER ORDER FULFILLMENT AND METHOD FOR RETAIL ESTABLISHMENT - A store mobile cloud application system executes a retail store purchasing system having plurality of barcode scanners and scan guns integrated with a mobile tablet device carried by employees. The mobile tablet device is rotatably attached to a base housing directly below it connected by a base mount universal receiver with rotatable coupling. The Main PCB has an EEPROM controlling operations of the USB devices including the scanner and an MSR. The mobile tablet device has mobile applications which allow wireless communication with a POS store systems server and the corporate ERP system, and also commands the EEPROM. Scanned data involving a product to be purchased is received by the mobile tablet device and sent wirelessly to the POS store systems server to obtain product data. The allocation of inventory sold, but not available in the store, are processed real-time through the corporate ERP system and available for review chain-wide. | 09-04-2014 |
20160055357 | Mobile barcode scanner gun system with mobile tablet device having a mobile Pos and enterprise resource planning application for customer checkout/order fulfillment and real time in store inventory management for retail establishment - A mobile scanner gun system efficiently and reliably processes a retail store purchase and/or performs daily store inventory management functions. The system has a main body portion extending toward a handle portion, the main body portion having a base, side walls, a front wall and a back wall constructed to form an interior cavity, wherein the front wall includes an aperture with a lens recessed therein. The front wall has a trigger member located near the base of the main body. A USB scanner input device is mounted above and in front of the trigger, the scanner having two drivers, including 1) a native device driver and 2) a keyboard input driver, the scanner device being in communication with the trigger for initiating a scan of a barcode. A USB MSR input device is integrated on the short edge of the mobile tablet device (upper receiver) and is used for processing payment card sales transactions through a secured PCI compliant, end to end encrypted bank card processor. The top wall of the main body portion includes an attachment means comprising a base mount universal receiver with rotational coupling means and a specialized universal serial bus wiring harness adapted to interchangeably mount and communicate with a mobile tablet device having a system integrated therein that enables real-time store level inventory management and a fully functioning POS capability for selling merchandise in a retail sales environment. The base mount universal receiver with rotational coupling allows the mobile tablet device to rotate from portrait mode to landscape mode without operational delay of the system. | 02-25-2016 |
Patent application number | Description | Published |
20090188827 | Blister package - A blister package is provided for retaining individual product units. The blister package is formed by a receptacle substrate and an outer laminate. The receptacle substrate includes a sealing flange and one or more receptacle hollows for retaining product therein. The outer laminate includes a first layer covering a sealing layer, with the sealing layer bonded to the receptacle flange and covering the product within the hollows. A repeating score line pattern is formed in the outer laminate for promoting a tear in the laminate upon forcing the product from the receptacle hollow against the outer laminate. The score pattern extends substantially across the area of the outer laminate covering the receptacle hollow and includes a plurality of spaced score lines formed in a crosswise relationship. | 07-30-2009 |
20120061282 | Blister Package - A blister package is provided for retaining individual product units. The blister package is formed by a receptacle substrate and an outer laminate. The receptacle substrate includes a sealing flange and one or more receptacle hollows for retaining product therein. The outer laminate includes a first layer covering a sealing layer, with the sealing layer bonded to the receptacle flange and covering the product within the hollows. A repeating score line pattern is formed in the outer laminate for promoting a tear in the laminate upon forcing the product from the receptacle hollow against the outer laminate. The score pattern extends substantially across the area of the outer laminate covering the receptacle hollow and includes a plurality of spaced score lines formed in a crosswise relationship. | 03-15-2012 |
20130008825 | BLISTER PACKAGE AND METHOD OF FORMING SAME - A blister package is defined for retaining product. The package is formed from a receptacle substrate having a planer sealing flange and at least one receptacle hollow for retaining product therein. A top layer is provided, covering the receptacle hollow with a portion overlapping and sealed to the sealing flange. A score pattern is formed in the top layer for promoting propagation of a tear upon forcing product from receptacle hollow against the top layer. The score pattern is defined by a plurality of rows of parallel straight lines aligned with the receptacle hollow. In addition, a plurality of spaced curved or bowed score lines are provided. The curved or bowed score lines transversely intersect the rows of straight lines above the receptacle hollow. | 01-10-2013 |
20130182977 | FLEXIBLE PACKAGE - A package for retaining consumable products is formed by a planar sheet or web of a flexible material that is folded about a plurality of aligned products. The fold of the sheet defines one side edge of the package. The other three side edges of the package are formed by sealing the front and back panel portions of the sheet to one another. An opening mechanism is provided for exposing at least a portion of the products retained within the package. The opening mechanism may be provided along the folded side edge of the package, at a corner of the package, adjacent to one of the sealed side edges. Other forms of opening means may also be formed along one of the seal edges along with means for resealing the opened package. | 07-18-2013 |
20130206632 | PACKAGE FOR STACKED PRODUCT PIECES HAVING A PATTERN OF SEVERABLE LOCATIONS - A package supports and dispenses one or more longitudinally stacked product pieces ( | 08-15-2013 |
20130306511 | DIE-CUT PATTERNS FOR BLISTER PACKAGE - A blister package is formed for retaining individual products. The package includes a receptacle substrate having a sealing flange and at least one receiving cell formed to retain product therein. A polymer top layer covers the cell and a portion thereof is sealed to the sealing flange. A score pattern is formed in at least one surface of the top layer and overlapping the cell. The score pattern is defined by a first plurality of score lines formed in a repeating pattern and a second plurality of score lines formed in a repeating pattern. The first and second plurality of rows overlap one another to define a plurality of intersections, with the overall score line pattern having a total linear length of the score lines per cell of at least 5 inches and a total number of score line intersections per cell of at least 10. | 11-21-2013 |
Patent application number | Description | Published |
20090234295 | Suture Securement Apparatus - A suture securement apparatus for selectively securing one or more ends of a suture while allowing adjustments in the tension or a full release of the sutures intermittently after a prolonged period of time. The suture securement apparatus can be particularly adapted for use with a purse-string suture to close a percutaneous catheter insertion site without causing puckering or distortion of the skin at the purse string suture site. The suture securement apparatus allows for subsequent modification of the amount of tensioning or full release of the sutures at the catheter insertion site. A threading assembly for use with the suture securement apparatus and being adapted to facilitate threading of sutures along the length of the suture securement apparatus. An adhesive suture securement device to provide securing sutures to be utilized with a suture securement apparatus. An adhesive securement device to provide a cradle configured to secure a hub of a catheter or other medical instrument or device. | 09-17-2009 |
20100051491 | SHARPS HANDLING DEVICES - A sharps handling device can include a base and a holder. The base and the holder can form a stand in which sharps devices can be retained so as to be accessible. The base and the holder can also form a container for enclosing sharps devices. | 03-04-2010 |
20100057110 | SURGICAL SECUREMENT SYSTEM AND APPARATUS - A surgical securement apparatus for selectively securing one or more ends of a cord while allowing adjustments in the tension or a full release of the cord intermittently after a prolonged period of time. A surgical securement and marking system utilizing one or more surgical securement apparatus that are color-coded to convey information about the associated intercorporeal structures. The surgical securement apparatus can be particularly adapted for use in securing intracorporeal structures such as nerves, blood vessels, and tendons during a surgical procedure. An extender tube connected to the surgical securement apparatus enables securement of intracorporeal structures within the surgical site from outside the surgical site. The surgical securement apparatus permits a practitioner to subsequently modify the amount of tensioning or to fully release the cord. A threading assembly for use with the surgical securement apparatus that is adapted to facilitate threading of a cord along the length of the surgical securement apparatus. | 03-04-2010 |
20100280541 | RADIAL ARTERY COMPRESSION DEVICE - A radial artery compression device configured to be secured to a wrist or other portion of a patient to provide adjustable and consistent compression pressure in the area of a radial artery access site or other physiological portion of a patient to achieve hemostasis either during or after a medical procedure such as a percutaneous coronary procedure. The radial artery compression device includes a rotatable member and a compression pad adapted such that rotation of the rotatable member does not affect the rotational orientation of the compression pad. According to one embodiment of the present invention, a single rotation of the rotatable member results in complete extension or retraction of the radial artery compression device. According to another embodiment of the present invention, the rotation of the rotatable member results in a compounding of the extension or retraction of the compression pad relative to the body of the radial artery compression device. | 11-04-2010 |
20110301496 | BIOPSY COLLECTION DEVICE AND RELATED METHODS - A biopsy collection device may include a filter located distally of an aspiration device to collect a biological sample aspirated from a patient. The biological sample may be accessible to a clinician without the need to expel the sample from the aspiration device. The filter may be disposed in a filter housing that is in fluid communication with the aspiration device and the vasculature of a patient. | 12-08-2011 |
20120197075 | ENDOSCOPE SECUREMENT DEVICE AND METHOD OF USE - An endoscope securement device for coupling an endoscope to the body of a practitioner. The endoscope securement device includes a base capable of being coupled to a practitioner and an articulable arm extending from the base configured to be coupled to an endoscope. The device allows a practitioner to manipulate the endoscope through his or her body movements, leaving his or her hands free to manipulate accessories to the device or other tools. | 08-02-2012 |
20130123693 | MECHANICALLY ASSISTED INFLATION DEVICE HANDLE AND METHOD OF USE - An inflation device including a handle mechanism configured to selectively engage and disengage threads within the device. In some instances the threads are configured to couple a plunger to a syringe body. The handle mechanism may be configured to (1) provide a mechanical advantage and (2) change the location and direction of the input force, thereby making the device easier to use. | 05-16-2013 |
20130123836 | RADIAL ARTERY COMPRESSION DEVICE - A radial artery compression device configured to be secured to a wrist or other portion of a patient to provide adjustable and consistent compression pressure in the area of a radial artery access site or other physiological portion of a patient to achieve hemostasis either during or after a medical procedure such as a percutaneous coronary procedure. The radial artery compression device includes a rotatable member and a compression pad adapted such that rotation of the rotatable member does not affect the rotational orientation of the compression pad. According to one embodiment of the present invention, a single rotation of the rotatable member results in complete extension or retraction of the radial artery compression device. According to another embodiment of the present invention, the rotation of the rotatable member results in a compounding of the extension or retraction of the compression pad relative to the body of the radial artery compression device. | 05-16-2013 |
20130204130 | DEVICES, SYSTEMS AND METHODS FOR CARBON DIOXIDE ANGIOGRAPHY - Disclosed herein are various embodiments of devices, systems and methods for the delivery of carbon dioxide (CO | 08-08-2013 |
20130331780 | MECHANICALLY ASSISTED INFLATION DEVICE HANDLE AND METHOD OF USE - An inflation device including a handle mechanism configured to selectively engage and disengage threads within the device. In some instances the threads are configured to couple a plunger to a syringe body. The handle mechanism may be configured to (1) provide a mechanical advantage and (2) change the location and direction of the input force, thereby making the device easier to use. | 12-12-2013 |
20140018845 | RADIAL ARTERY COMPRESSION DEVICE - A radial artery compression device configured to be secured to a wrist or other portion of a patient to provide adjustable and consistent compression pressure in the area of a radial artery access site or other physiological portion of a patient to achieve hemostasis either during or after a medical procedure such as a percutaneous coronary procedure. The radial artery compression device includes a rotatable member and a compression pad adapted such that rotation of the rotatable member does not affect the rotational orientation of the compression pad. According to one embodiment of the present invention, a single rotation of the rotatable member results in complete extension or retraction of the radial artery compression device. According to another embodiment of the present invention, the rotation of the rotatable member results in a compounding of the extension or retraction of the compression pad relative to the body of the radial artery compression device. | 01-16-2014 |
20140200548 | APPARATUSES AND KITS FOR GRINDING OR CUTTING SURGICAL FOAM AND METHODS RELATED THERETO - Apparatuses for grinding or cutting surgical foam are disclosed herein. Kits for grinding or cutting surgical foam are disclosed herein. Methods of grinding surgical foam with a plurality of teeth are disclosed herein. Methods of cutting surgical foam are disclosed herein. Methods of embolizing with ground or cut surgical foam are disclosed herein. | 07-17-2014 |
20140254303 | MIXING SYRINGE - A movable mixing disc may be utilized in connection with a syringe. The mixing disc may comprise a hole which may be covered by a fine screen or coupled to a porous member, allowing only certain elements of a solution to pass through the mixing disc. Actuation of a plunger of the syringe may cause liquid to emerge from the mixing disc hole as a high velocity jet or other turbulent flow, stirring up any settled particles on a distal side of the mixing disc. As the ejection continues, the mixing disc may be pushed forward by the plunger in order to eliminate any unused volume. Also, the mixing disc may be moved forward by virtue of a pressure difference created by a pressure drop across the mixing disc, such as a pressure drop created as the plunger is displaced to induce fluid flow across the mixing disc. | 09-11-2014 |
20140276592 | LOCKABLE SYRINGE ASSEMBLIES AND RELATED DEVICES AND METHODS - The embodiments disclosed herein relate to lockable syringe assemblies and related devices and methods. The syringe assembly may include a barrel, a plunger, and a locking mechanism. In some arrangements, the locking mechanism is an elastomeric locking ring or a rigid partial ring. The plunger may include a plurality of ribs and is longitudinally moveable within the barrel. Once the plunger is disposed at a desired longitudinal location, the plunger can be axially rotated and locked in such a way that further longitudinal movement is restricted. | 09-18-2014 |
20150045828 | VASCULAR FILTER DELIVERY SYSTEMS AND METHODS - A filter configured to be disposed within the vasculature to capture or trap material within a body lumen is disclosed. The filter may be configured to be removable and may be configured to slice through ingrown or encapsulated tissue during removal. A filter deployment device or system which may be configured to deliver a filter or filters to a position within a body lumen, such as within the vasculature, is also disclosed. The filter deployment device may be configured to limit inadvertent decoupling of a filter. Also, the filter deployment device may be configured to retrieve a deployed filter. | 02-12-2015 |
Patent application number | Description | Published |
20090253200 | CADHERIN-11 ANTAGONISTS AND METHODS FOR THE TREATMENT OF INFLAMMATORY JOINT DISORDERS - The present invention relates to Cadherin-11 antagonists and compositions comprising Cadherin-11 antagonists. The invention also relates to methods for treating inflammatory joint disorders, such as rheumatoid arthritis, in a mammalian subject by administering a therapeutically effective amount of a Cadherin-11 antagonist. | 10-08-2009 |
20110008323 | Cadherin-11 EC1 Domain Antagonists for Treating Inflammatory Joint Disorders - The present invention relates to Cadherin-11 antagonists and compositions comprising Cadherin-11 antagonists. The invention also relates to methods for treating inflammatory joint disorders, such as rheumaotid arthritis, in a mammalian subject by administering a therapeutically effective amount of a Cadherin-11 antagonist. | 01-13-2011 |
20110045003 | CADHERIN-11 ANTAGONISTS AND METHODS FOR THE TREATMENT OF INFLAMMATORY JOINT DISORDERS - The present invention relates to Cadherin-11 antagonists and compositions comprising Cadherin-11 antagonists. The invention also relates to methods for treating inflammatory joint disorders, such as rheumatoid arthritis, in a mammalian subject by administering a therapeutically effective amount of a Cadherin-11 antagonist. | 02-24-2011 |
20130189251 | HUMANIZED ANTIBODIES TARGETING THE EC1 DOMAIN OF CADHERIN-11 AND RELATED COMPOSITIONS AND METHODS - The present invention relates to humanized antibodies that specifically bind an EC1 domain of a mammalian Cadherin-11 protein and compositions (e.g., pharmaceutical compositions) comprising such antibodies. The invention also relates to methods for treating Cadherin-11-mediated disorders in a mammalian subject by administering a therapeutically effective amount of a humanized antibody of the invention. Cadherin-11-mediated disorders suitable for treatment by the methods of the invention include inflammatory disorders (e.g., inflammatory joint disorders, such as rheumatoid arthritis), fibrosis and cancer. | 07-25-2013 |
20140120104 | CADHERIN-11 EC1 DOMAIN ANTAGONISTS FOR TREATING INFLAMMATORY JOINT DISORDERS - The present invention relates to Cadherin-11 antagonists and compositions comprising Cadherin-11 antagonists. The invention also relates to methods for treating inflammatory joint disorders, such as rheumaotid arthritis, in a mammalian subject by administering a therapeutically effective amount of a Cadherin-11 antagonist. | 05-01-2014 |
20150132305 | Humanized Antibodies Targeting the EC1 Domain of Cadherin-11 and Related Compositions and Methods - The present invention relates to humanized antibodies that specifically bind an EC1 domain of a mammalian Cadherin-11 protein and compositions (e.g., pharmaceutical compositions) comprising such antibodies. The invention also relates to methods for treating Cadherin-11-mediated disorders in a mammalian subject by administering a therapeutically effective amount of a humanized antibody of the invention. Cadherin-11-mediated disorders suitable for treatment by the methods of the invention include inflammatory disorders (e.g., inflammatory joint disorders, such as rheumatoid arthritis), fibrosis and cancer. | 05-14-2015 |
Patent application number | Description | Published |
20090298906 | PROTEASOME INHIBITORS - Disclosed herein are compounds of Formula (I) that include a sulfonate ester, ester or ether group. Compounds of Formula (I) can be included in pharmaceutical compositions, and can be used to treating and/or ameliorating a disease or condition, such as cancer, a microbial disease and/or inflammation. | 12-03-2009 |
20110105762 | TOTAL SYNTHESIS OF SALINOSPORAMIDE A AND ANALOGS THEREOF - The present invention relates to certain compounds and to methods for the preparation of certain compounds that can be used in the fields of chemistry and medicine. Specifically, described herein are methods for the preparation of various compounds and intermediates, and the compounds and intermediates themselves. More specifically, described herein are methods for synthesizing Salinosporamide A and its analogs from a compound of formula (V). | 05-05-2011 |
20110172285 | PROTEASOME INHIBITORS - Disclosed herein are compounds of Formula (I) that include a sulfonate ester, ester or ether group. Compounds of Formula (I) can be included in pharmaceutical compositions, and can be used to treating and/or ameliorating a disease or condition, such as cancer, a microbial disease and/or inflammation. | 07-14-2011 |
20120270919 | PROTEASOME INHIBITORS - Disclosed herein are compounds of Formula (I) that include a sulfonate ester, ester or ether group. Compounds of Formula (I) can be included in pharmaceutical compositions, and can be used to treating and/or ameliorating a disease or condition, such as cancer, a microbial disease and/or inflammation. | 10-25-2012 |